KR20020044267A - Cosmetic composition for skin whitening comprising an extract from rubus coreanus miq - Google Patents

Abstract

PURPOSE: Provided is a cosmetic composition for skin whitening comprising, as an active ingredient, the extract from Rubus coreanus MIQ which has excellent skin whitening effects as well as treatment effects on a freckle and a pimple. CONSTITUTION: The cosmetic composition for skin whitening comprises the extract of Rubus coreanus MIQ with at least one selected from the group consisting of Aralia cordata THUNB, Astragalus membranaceus BGE, Carthamus tinctorius L, Cinnamomum loureirii NEES, Cinnamomum japonicum SIEB, Salix babylonia L., and Coix lachryma-jobi L.

Description

Cosmetic composition for whitening treatment comprising bokbunja extract {COSMETIC COMPOSITION FOR SKIN WHITENING COMPRISING AN EXTRACT FROM RUBUS COREANUS MIQ}

The present invention relates to a cosmetic composition comprising a bokbunja extract, and more particularly, at least one herbal drug selected from the group consisting of bokbunja extract as an active ingredient, poisonous, Astragalus, safflower, cinnamon, cinnamon, roots of Yui, Euiin and aloe vera The present invention relates to a composition for maximizing skin whitening function consisting of complex herbal extracts in which the extract is arbitrarily combined.

The pigments that determine human skin color include melanin hemoglobin and carotenoids. The various colors of skin, hair and eyes are determined by these pigments. The most important pigment that determines the color of skin is melanin, and the color of skin depends on the amount, nature and distribution of melanin.

In humans, the pigments in the skin and hair protect the skin and hair from the harmful effects of sunlight (especially ultraviolet rays). For example, people with poor pigmentation (albino disease) are very sensitive to sunlight and are prone to burns. Short wavelength ultraviolet rays (290-320 nm) and carcinogens form oxygen radicals in the skin, which are known to attack skin cells and age the skin.

The main function of melanin is to remove oxygen radicals and protect the skin from the damage thereby. Therefore, high levels of melanin mean that it has an effective response system to protect the skin from physical and chemical toxicants.

Melanogenesis is due to factors such as ultraviolet rays, estrogens, prostaglandins, and bleomycin in melanocytes in melanocytes, increasing the melanogenesis. It is delivered to keratinocytes and accumulated in the epidermis. Hyperpigmentation of the skin due to blemishes, freckles, skin darkening after skin inflammation, senile pigment spots, etc. can cause not only cosmetic discomfort but also negative psychological effects on the person, leading to discomfort in social activities. Due to the increased demand, cosmetics and pharmaceutical products for whitening are being marketed to prevent and improve them.

The research of whitening agent as cosmetics has a history of less than 10 years, and the necessity is gradually increasing as skin blackening is recognized as skin aging caused by ultraviolet rays along with the improvement of living standard in the Asian region which prefers emotionally white skin. Since 1990, arbutin, kojic acid, vitamin C and derivatives thereof have been developed and commercialized whitening cosmetics containing them, but the actual clinical effect is not satisfactory and excessive pigmentation As a medicine for improvement, hydroquinone, sulfure, azelaic acid and retinoic acid are used, but they have great irritation and toxicity.

The initial development of whitening agents focused on the antioxidant activity of tyrosine by tyrosinase, the first step in the melanin pigmentation process, so screening tyrosinase activity inhibitors in vitro was an important developmental tool. In particular, the tyrosinase used is derived from mushrooms, and there are many differences in similarity to humans. If the selected whitening agent is applied to the human body, there are problems such as skin penetration, cytotoxicity, and stability in the formulation. There is a lack of practical clinical effects, but arbutin, kojic acid, and vitamin C found in this process are still widely used.

Recently, in order to develop a whitening cosmetics having relatively low toxicity and nature-friendly cosmetics, it has been found that several plants are effective for whitening. As an example, Korean Patent Publication No. 1991-8660 discloses a whitening cosmetic material containing a mulberry extract, and Korean Patent Publication No. 1991-11645 discloses a whitening cosmetic containing a extract of Hojang-geun. No. 1993-8377 discloses a whitening composition containing an extract of Cypress, and in Korea Patent Publication No. 1993-28783, a whitening composition containing an extract of white skin is disclosed, but until now the extract of Bokbunja as an active ingredient There is no known whitening effect of the composition.

As a result of experimenting on the whitening effect of various plants, the inventors have found the efficacy of the extract of Bokbunja, which shows the excellent whitening effect. As a result of the formulation, it was found to show equivalent to more excellent whitening efficacy and confirmed it.

An object of the present invention is to provide a cosmetic composition excellent in whitening effect using the bokbunja extract as an active ingredient.

It is another object of the present invention to provide a cosmetic composition excellent in whitening effect using the extract as an active ingredient.

It is another object of the present invention to provide a cosmetic composition excellent in whitening effect using safflower extract as an active ingredient.

Another object of the present invention is to provide a cosmetic composition excellent in whitening effect using the extract as an active ingredient.

Another object of the present invention is to provide a cosmetic composition excellent in whitening effect using the cinnamon extract as an active ingredient.

It is another object of the present invention to provide a cosmetic composition excellent in whitening effect using the root extract as an active ingredient.

Still another object of the present invention is to provide a whitening cosmetic composition comprising a compound herbal extract comprising one or more herbal extracts selected from the group consisting of venom, astragalus, safflower, cinnamon, cinnamon, root root, uiyiin and aloe vera in bokbunja extract To provide.

Another object of the present invention is to provide a whitening cosmetic composition consisting of 50 to 70% by weight bokbunja extract and 30 to 50% by weight poison extract.

Still another object of the present invention is to provide a whitening cosmetic composition consisting of 45 to 60% by weight of bokbunja extract, 30 to 35% by weight of poisonous extract and 5 to 15% by weight of Astragalus extract.

Still another object of the present invention is to provide a whitening cosmetic composition consisting of 40 to 45% by weight of bokbunja extract, 25 to 30% by weight of poisonous extract, 10 to 15% by weight of Astragalus extract and 15 to 20% by weight of safflower extract.

Another object of the present invention is a whitening cosmetic composition consisting of 25 to 30% by weight of bokbunja extract, 15 to 20% by weight of poisonous extract, 5 to 10% by weight of Astragalus extract, 10 to 15% by weight of safflower extract and 30 to 35% by weight of cinnamon extract It is to provide a composition.

Another object of the present invention is 15 to 20% by weight of Bokbunja extract, 10 to 15% by weight poison extract, 2 to 6% by weight Astragalus extract, 5 to 10% by weight safflower extract, 18 to 23% by weight cinnamon extract and cinnamon extract 35 It is to provide a whitening cosmetic composition consisting of to 40% by weight.

Another object of the present invention is 10 to 15% by weight bokbunja extract, 5 to 8% by weight poison extract, 1 to 4% by weight Astragalus extract, 4 to 7% by weight safflower extract, 13 to 17% by weight cinnamon extract, cinnamon extract 25 It is to provide a whitening cosmetic composition consisting of to 28 to 28% by weight and 25 to 28% by weight of the root extract.

Another object of the present invention is 10 to 13% by weight bokbunja extract, 5 to 8% by weight poison extract, 1 to 4% by weight Astragalus extract, 4 to 7% by weight safflower extract, 13 to 16% by weight cinnamon extract, cinnamon extract 25 It is to provide a whitening cosmetic composition consisting of to 27% by weight, 25 to 27% by weight of the extract of Yukje skin and 5 to 7% by weight of the extract of Euiin.

Another object of the present invention is 10 to 12% by weight bokbunja extract, 6 to 8% by weight poison extract, 2 to 4% by weight Astragalus extract, 4 to 6% by weight safflower extract, 13 to 15% by weight cinnamon extract, cinnamon extract 24 To 26% by weight, Root skin extract 24 to 26% by weight, Euiyi extract 5-7% by weight and Aloe vera extract 1 to 3% by weight to provide a whitening cosmetic composition.

According to the above purpose, as a result of searching for an excellent whitening medicine, the cosmetic composition comprising the extract of Bokbunja found that the excellent efficacy, and also the poisonous, Astragalus, safflower, cinnamon, cinnamon, root roots, uiyiin and aloe vera One or more herbal extracts selected from the group consisting of maximizing the skin whitening function consisting of a combination of herbal extracts optionally combined to complete the present invention.

Bokbunja is an immature seed of Rubus coreanus MIQ, distributed in Jeju-do and South-South provinces. In oriental medicine, it is used to treat diseases such as stomach, oil well, urinary tract, and erosion. Until now, known components such as carboxylic acid (CarvoneAcid) have been reported.

Toxic activity is the root and rhizome of Aralia cordata THUNB, which is distributed in wetlands nationwide, and is used for the treatment of colds, headaches, rheumatism and neuralgia in oriental medicine. Limonene, Terpene compounds such as sabinene and kaur-16-en-19-oic acid have been reported separately.

Astragalus is the root of Astragalus membranaceus BGE, which is distributed on mountain slopes and hillsides on both sides, and is cultivated as a medicinal plant. It is used for the treatment of Jahan and Dohan in oriental medicine. Actions, capillary potentiation, and antimicrobial activity have been reported, and 2 ', 4'-dihydroxy-5,6-dimethoxyisoflavan and kumatakenin are reported to be known so far. It has been.

Safflower is a fruit of Carthamus tinctorius L., native to Egypt and cultivated throughout the country. In oriental medicine, it has been used for the treatment of amenorrhea, fish line, stillbirth, and bruises. It has been reported that hypothermia, blood coagulation inhibitory action, and the like components such as linolenic acid, oleic acid.

Gyeji (桂枝) is a branch of Cinnamomum loureirii NEES, is used in the treatment of headache, muscle spasms, etc. in oriental medicine, and has been reported in the antimicrobial, antiviral, antidiuretic effect.

Cinnamon is the eggplant bark of Cinnamomum japonicum SIEB, which is used for the treatment of hari abdominal pain, vomiting, etc. in oriental medicine, and known ingredients are phenlene and eugenol.

The roots of the weeping willow ( Salix babylonia L.) and the roots of the beard roots are cultivated in waterside wetlands and are used for the treatment of gonorrhea, jaundice, rheumatic headaches, toothaches and burns. As far as known ingredients such as salin (saicin) has been reported.

Euiin (인 仁) is a seed of Yulmu ( Coix lachryma-jobi L.), which is used for the treatment of diarrhea, drainage, diarrhea, water species, and others in oriental medicine. , Uterine contraction, intestinal motility control action has been reported, and known components such as coixol (coixol), coixenolide (coixenolide), cytosterol, stigmasterol and the like have been reported.

Aloe vera L is a perennial herb and is native to Africa and is also cultivated in Korea. It is used for the treatment of pediatric cramps and dysmenorrhea in oriental medicine, and clinically reported to have hypothalamic, wound healing and anticancer activity. Known components, such as aloin (aloin), coumaric acid (coumaric acid) has been reported separately.

Herbal extracts of the present invention can be prepared according to a conventional method, for example, dry and finely toxic dry water or lower alcohol, preferably 90% methanol, such as methanol, ethanol and 5 to 80 ℃, Preferably it can be obtained by extracting for 15 minutes to 48 hours, preferably 30 minutes to 12 hours at 30 to 55 ℃, the herbal extracts of solid forms such as bokbunja, uiyiin, safflower are ground by a pulverizer The extract can be obtained through the same process.

Among the extracts obtained by the above-mentioned extract preparation method, the bokbunja extract showed an excellent whitening effect. It was found to show a synergistic effect.

When using the herbal extract, the extract is 50 to 70% by weight bokbunja extract and 30 to 50% by weight poison extract; Or 45-60 wt% of Bokbunja extract, 30-35 wt% of venom extract and 5-15 wt% of Astragalus extract; Or 40 to 45% by weight of Bokbunja extract, 25 to 30% by weight of poisonous extract, 10 to 15% by weight of Astragalus extract and 15 to 20% by weight of safflower extract; Or 25-30% by weight of Bokbunja extract, 15-20% by weight of poisonous extract, 5-10% by weight of Astragalus extract, 10-15% by weight of safflower extract and 30-35% by weight of gye extract; Or 15-20 wt% of Bokbunja extract, 10-15 wt% of venom extract, 2-6 wt% of Astragalus extract, 5-10 wt% of safflower extract, 18-23 wt% of cinnamon extract and 35-40 wt% of cinnamon extract; Or 10 to 15% by weight bokbunja extract, 5 to 8% by weight poison extract, 1 to 4% by weight Astragalus extract, 4 to 7% by weight safflower extract, 13 to 17% by weight cinnamon extract, 25 to 28% by weight cinnamon extract 25 to 28 wt% extract; Or 10 to 13% by weight bokbunja extract, 5 to 8% by weight poison extract, 1 to 4% by weight Astragalus extract, 4 to 7% by weight safflower extract, 13 to 16% by weight cinnamon extract, 25 to 27% by weight cinnamon extract 25 to 27% by weight of the extract and 5 to 7% by weight of Euiin extract; Or 10 to 12% by weight bokbunja extract, 6 to 8% by weight poison extract, 2 to 4% by weight Astragalus extract, 4 to 6% by weight safflower extract, 13 to 15% by weight cinnamon extract, 24 to 26% by weight cinnamon extract It may consist of 24 to 26% by weight of the extract, 5 to 7% by weight of Euiyi extract and 1 to 3% by weight of aloe vera extract.

A bokbunja extract or a composite herbal extract as described above may be mixed with a conventional cosmetic preparation base material to prepare a whitening cosmetic composition.

In the present invention, Bokbunja alone or combined extract with Astragalus, Astragalus, Safflower, Cinnamon, Cinnamon, Yugeunpi, Uiin and Aloe Vera extracts is used in an amount of 0.0001% to 20.00% by weight based on the skin cosmetic composition. In addition, the base material for preparing the cosmetic composition is purified water, monohydric or polyhydric alcohol fats and oils, surfactants and the like on the emulsion, and other flavoring agents, coloring agents, preservatives and the like. In the solubilized state, purified water, surfactants, monohydric and polyhydric alcohols, and the like, and flavoring agents, colorants, and preservatives are used as in the emulsion phase.

In skin cosmetics, creams and lotions may be prepared as V / O emulsions and O / W emulsions, respectively, and the type of emulsifier used may be classified into anionic form, cationic form, and nonionic form.

Hereinafter, the present invention will be described in more detail with reference to the following examples. However, the following Examples are only for illustrating the present invention, and the scope of the present invention is not limited to these.

Example 1 Preparation of Bokbunja Extract

500 g of bokbunja isolated from the flesh of the bokbunja strawberry tree collected from Naejangsan, Korea, was crushed with iron mortar, and then 500% of 90% ethanol was added and lyophilized 90% ethanol extract obtained through the reflux apparatus to obtain 18 g of dried product. .

Example 2 Preparation of Toxic Extract

After 500 g of the poisonous toxin purchased in the Gyeongdong market, Jongam-dong, Seoul was chopped, 500 ml of 90% ethanol was added thereto and 90 g of the ethanol extract obtained through the reflux apparatus was lyophilized to obtain 25 g of the dried product.

Example 3 Preparation of Aloe Vera Extract

1 kg of aloe purchased at Gyeongdong Market, Seoul, Korea was peeled off with a knife, 500 ml of colorless transparent gel aloe in the stem was put in water, and the water extract obtained through the reflux device was obtained by drying the freeze-dried dried product 30 g.

Examples 4-7 : The roots of the roots of the root extract, Astragalus, Cinnamon and Cinnamon obtained by the extraction method of the poisonous extract described in Example 2 were lyophilized to obtain dried products 23, 20, 20 and 23 g each.

Examples 8 to 9 : Uyiinin and safflower extracts obtained by the extracting method of Bokbunja extract described in Example 1 were lyophilized to obtain dried products 21 and 20g.

Examples 10-17 : Each herbal extract dried was combined as described in Table 1 below.

(Unit weight%) Herbal Example Bokbunja Poisonous Astragalus Safflower Cock cinnamon Root skin Righteous Aloe 10 63.5 36.5 11 54.5 31.5 14.0 12 43.7 25.2 11.2 19.9 13 29.0 16.8 7.5 13.2 33.5 14 17.9 10.3 4.6 8.1 20.6 38.05 15 12.9 7.4 3.2 5.9 14.8 27.8 27.8 16 12.1 6.9 3.1 5.5 13.9 26.1 26.1 6.3 17 11.7 6.8 3.0 5.4 13.5 25.3 25.2 6.0 2.9

Example 18 Preparation of Cream 1

Cream is based on the following composition.

Component Content (% by weight) Dry product obtained in Example 1 0.05 Carbomer 940 0.3 Triethanol amine 0.3 stearin 3.0 Cetyl alcohol 2.0 Self-emulsifying glyceryl monostearate 3.0 Soybean oil 10.0 Lanolin alcohol 2.0 Isopropyl myristate 4.0 Cetyl and stearyl 2-ethylhexanoate 4.0 Perhydrosqualene 3.0 Purified water Quantity sum 100

To prepare this cream, an aqueous phase comprising glyceryl monostearate, perhydrosqualene as a preservative, and purified water was heated to 80 ° C; Dispersing carbomer 940 therein; This was neutralized with triethanolamine. The remaining lipid phase components, heated to 80 ° C. and homogenized, were added to the neutralized aqueous phase with vigorous stirring. The dried product of Example 1 was dispersed in 10 g of water and poured into cream with stirring at 40 ° C. The mixture was cooled to room temperature.

Examples 19-26 Preparation of Creams 2-9

Creams 2 to 9 were prepared in the same manner as in Example 18, except that the dry blends obtained from Examples 10 to 17 were substituted for the dry matter of Example 1 of Cream 1 of Example 18.

Example 27 Confirmation of Whitening Effect

In this example, the whitening effect appeared after using the creams for healthy volunteers.

a) Limited Line (Female)

Residence: Daegu

How to use: 36 consecutive days once daily

effect

After about 10 days, the spots and freckles became noticeably pale, and after makeup, some troubles appeared and disappeared. The face color was dark and black, but it became much brighter and went back to the original skin color.

b) Mrs. Song Ki-woong (Female)

Residence: Sanggye-dong, Seoul

How to use: Pack face to face once a day before bed and use as a cleansing cream to remove with this cream one or two hours later.

effect

After 7 days your face will turn white and clear.

c) Park Dan Sim (Female)

effect

I have a blemish on my face and almost no blemish on it.

d) roses (women)

effect

I recommended it to my youngest brother, and her face became clean and white for two weeks.

e) Park Min Jung (Female)

Residence: Samcheonpo

effect

I had freckles and applied it for 10 days, but there was almost no freckles.

f) Go Ok (Female)

Residence: Damyang, Jeonnam

effect

After one month of use, the skin became thinner and the skin became clearer.

Bokbunja alone or poisonous extract, Yugeun skin, Astragalus, Safflower, Cinnamon, Cinnamon, Uyiin and aloe extracts extracts effectively exhibit whitening activity and are useful for preventing and treating freckles or freckles of the skin.

Claims (17)

A whitening cosmetic composition comprising a composition containing Rubus coreanus MIQ extract as an active ingredient and a cosmetically applicable base. A whitening cosmetic composition comprising a composition comprising a poisonous extract ( Aralia cordata THUNB) as an active ingredient and a cosmetically applicable base. Astragalus membranaceus BGE (Whitening) A cosmetic composition comprising a composition comprising an extract as an active ingredient and a cosmetically applicable base. A whitening cosmetic composition comprising safflower ( Carthamus tinctorius L.) extract as an active ingredient and a composition containing a cosmetically applicable base. A whitening cosmetic composition comprising a composition comprising a Cinnamomum loureirii NEES. Extract as an active ingredient and a cosmetically applicable base. A whitening cosmetic composition comprising a composition comprising cinnamon ( Cinnamomum japonicum SIEB) extract as an active ingredient and a cosmetically applicable base. A whitening cosmetic composition comprising a composition containing a extract of Salix babylonia L. as an active ingredient and a cosmetically applicable base. Whitening cosmetic composition consisting of a composition containing Coix lachryma-jobi L. extract as an active ingredient and a cosmetically applicable base The method of claim 1, A whitening cosmetic composition comprising, as an active ingredient, a complex herbal extract in which bokbunja extract is combined with one or more herbal extracts selected from the group consisting of venom, astragalus, safflower, cinnamon, cinnamon, citrus root, uiyiin and aloe vera. The method of claim 9, Whitening cosmetic composition of the complex herbal extract consisting of 50 to 70% by weight of bokbunja extract and 30 to 50% by weight of poisonous extract. The method of claim 9, Whitening cosmetic composition of the complex herbal extract consisting of 45 to 60% by weight of Bokbunja extract, 30 to 35% by weight of poisonous extract and 5 to 15% by weight of Astragalus extract. The method of claim 9, Whitening cosmetic composition of the complex herbal extract is composed of 40 to 45% by weight bokbunja extract, 25 to 30% by weight poison extract, 10 to 15% by weight Astragalus extract and 15 to 20% by weight safflower extract. The method of claim 9, Whitening cosmetic composition of the complex herbal extract is composed of 25 to 30% by weight of bokbunja extract, 15 to 20% by weight of poisonous extract, 5 to 10% by weight of Astragalus extract, 10 to 15% by weight of safflower extract and 30 to 35% by weight of cinnamon extract. The method of claim 9, Complex herbal extract is 15 to 20% by weight bokbunja extract, 10 to 15% by weight poison extract, 2 to 6% by weight Astragalus extract, 5 to 10% by weight safflower extract, 18 to 23% by weight cinnamon extract and 35 to 40% by weight cinnamon extract Whitening cosmetic composition consisting of%. The method of claim 9, Combined herbal extracts are 10-15% by weight of Bokbunja extract, 5-8% by weight extract, Astragalus extract 1-4%, Safflower extract 4-7%, Cinnamon extract 13-17%, Cinnamon extract 25-28% Whitening cosmetic composition consisting of 25% to 28% by weight and root extract. The method of claim 9, Combined herbal extracts are 10 to 13% by weight bokbunja extract, 5 to 8% by weight extract, Astragalus extract 1 to 4%, safflower extract 4 to 7%, cinnamon extract 13 to 16%, cinnamon extract 25 to 27% Whitening cosmetic composition consisting of 25% to 27% by weight of the extract of Yugeun skin and 5 to 7% by weight of the extract of Euiin. The method of claim 9, Complex herbal extracts are 10 to 12% by weight bokbunja extract, 6 to 8% by weight poison extract, 2 to 4% by weight Astragalus extract, 4 to 6% by weight safflower extract, 13 to 15% by weight cinnamon extract, 24 to 26% by weight cinnamon extract Whitening cosmetic composition consisting of%, 24 ~ 26% by weight of the extract of Yu-Gi-Yu, 5-7% by weight of Euiin extract and 1-3% by weight of Aloe Vera extract.