KR20020013134A - Immune Modulator and food containing the same - Google Patents

Abstract

PURPOSE: An immunity controlling agent and functional food comprising an extract of Pogostemonis Herba, Atractylodis Rhizoma alba and Perilla frutescens var. acuta Kudo are provided, which can be used for controlling an abnormal immune function, in particular treatment and prevention of allergic nasal inflammation, influenza and the like. CONSTITUTION: A mixed natural drug of 100 parts by Pogostemonis Herba, 15 to 20 parts by weight of Atractylodis Rhizoma alba and 15 to 20 parts by weight of Perilla frutescens var. acuta Kudo is heated in water at 100deg.C for 4 hr to produce an immunomodulator. Various functional foods containing the extract are also obtained by the process.

Description

Immune Modulator and food containing the same

The present invention relates to a mixed extract medicament having an excellent effect on immune regulation and to alleviate side effects and a functional food containing the same.

Immunity originally meant a state of escape from punishment, duty, lessons, etc., but in medicine it is used to avoid disease. The concept of early immunity was mostly used in the field of infectious diseases, but gradually shifted to the concept of "again phenomena" (川 喜 田) beyond the general theory of being able to escape the disease (菊 地 浩 吉: state of the art immunology, Seoul, Munmundang, 1985, Recently, it is widely interpreted that "immunity is a function to cope with the confusion of the uniformity of physical properties of living organisms" (Moon, Hee-joo, Kwon, Hyuk-han: Basic Immunology, Seoul, University Seorim, 1996, p13).

Immune diseases include rheumatoid arthritis, lupus erythematosus, scleroderma, vasdous disease, myasthenia gravis, atrophic gastritis, ulcerative colitis, chronic active hepatitis, primary biliary cirrhosis primary thrombocytopenic purpura, hemorrhagic pneumonia, autoimmune Hemolytic anemia, chronic lymphocytic thyroiditis, adolescent diabetes, high fever, aggression, etc. (尤松: 免疫性 疾患 的 中醫 治療 (Medicinal Treatment of Immune Diseases), Tianjin, Tianjin University and Hebei, 1995.)

The immune response is impaired nonspecifically by several factors. In particular, cellular immunity is also hampered by malnutrition. This is also seen in the wealthy urban areas of the world, and iron deficiency is particularly important from a nutritional point of view.

Viral infections are immunosuppressive with a fairly high frequency. Human measles, chicken Newcastle disease, and cow's cow disease are due to the direct cytotoxic effects of the virus on lymphoid cells. It has been shown that in leprosy or leprosy, the immune response is suppressed by distortions into the normal lymphoid environment. In the latter case, serofactors of secondary syphilis patients, which block the transformation of macrophages by phytohemagglutinin (PHA), are also involved in the overall decrease in cellular immunity seen in the disease.

Many factors, such as X-rays, cytotoxic drugs, and corticosteroids, are commonly used irrespective of immunity, but actually have a significant risk effect on the immune system. B lymphocytic hyperplasia, such as chronic lymphocytic leukemia, myeloma and Waldenstrom's macroglobulinemia, is accompanied by a variety of low gamma globulinemia and disorders in antibody response. The common infection of purulent bacteria in these patients is in contrast to the case of Hodgkin's disease, which is susceptible to tuberculosis, Brucella, Cryptococcus and shingles virus, which are all characteristic of cellular immune deficiency. Ivan M. Roitt (Loit Essential Immunology, Seoul, Advisor, 1991, p219-212.)

Immunity, a modern bimedical concept, corresponds to the crisis from the perspective of traditional Chinese medicine. Crisis (衛 氣) is a part of the human body's yanggi, born in the grain, originated in the stomach and lauded in the vinegar to operate the extra pulse. It is strong in nature, unrestricted by the meridians, and the operation of the flag is quick and active. There is no place where the operation does not lead to a book inward and a sign ring. Crisis has important functions such as warming books and making donations warm, nourishing liquor, and opening and closing Han-Gong. Such a flag is called a crisis because it is characterized by the action of keeping voting marks and voting on external affairs (Kim Hyun-je et al .: Korean Medicine Dictionary, Seoul, Seongbosa, 1983, p166.)

Chinese medicine has a facilitating effect on a lowered immune response, which can enhance the function of the immune system and increase immunity. Thus, the immune response is promoted in favor of the body, leading to the reaching and treatment of an immune disease or antitumor.

Immunostimulating Chinese medicine, Astragalus, Ginseng, Ganoderma Lucidum, Dangsam, Baekchul, Fuling, Euiin, Contrast, Angelica, Cinnabar, Glue, Sukjihwang, Baekjak, Sirinja, Eumyangkwa, Earthenware, Breeding, Gyeyang, Pageokcheon, Bogolji, Green angle Gyo, Seonmo, Jahager, Broiler, Astronomical dong, Mcmundong, Hyunsam, Seokgok, Sasam, Gugija, Sansuyu, Journeyman, Hannyeoncho, Hwangjeong, Dongchunghacho, Sanggisaeng, Gogigi, Shouo, Spirit, Daesan, Baekhwasaeng, Golden, Hwangyeon, Eoseongcho, Cheonggung, safflower, and Dansam (Sung Nak-saeng: Immunology and Oriental Medicine, Seoul, Open Books, 1992) Prescriptions for immunization include Sagunjatang, Bojungikgitang, Samultang, Saengmaeksan, and Yumijihwangtang.

On the other hand, immune dysfunction is caused by an excessively high immune response, which leads to an immune disease when the body is damaged. This kind of response due to the suppression of demand is just over normal and when the imbalance is reached, it is the equilibrium of yin and yang in oriental medicine.

In immunosuppressive medicines, god, white nap, Changzai, Shiho, ephedra, jiji, seshin, hyunggae, windbreak, taxi, Banggi, crust, autograph, jyokyo, baekrye-sancho, cheonsimyeon, daecheongyeop, eoseongcho, yongdamcho, golden, Huangren, Huangbai, rhubarb, dansam, red peony, Samreung, Mokpipi, Cheongung, Doin, safflower, Achul, frankincense, myrrh, hemisphere, sesame, brain ball, etc. Immunosuppressive prescriptions include Gyeji-tang, Hwang-bang-dodoksan, Hwangyeonhaedak-tang, and Live Cheongdandan.

The immune response has many problems due to its many causes and types and complicated processes. Therefore, it is not solved by simple immunostimulants or inhibitors. Western medicines are not ideal, and Chinese medicines show a lot of organic coordination due to the active predisposition of the body. In this way, Chinese medicine treats the body's own regulatory system, so it is advantageous to exercise human health. This is the equilibrium of yin and yang. Chinese medicine is not a small number of yin and yang control action, too high functional state is lowered, and too high to lower the normal state is maintained.

The immunomodulatory effect of Chinese medicine can be explained generally as follows.

1) passing

Hypothalamic-pituitary-adrenal cortex has an immunomodulatory effect. The kidney and the hypothalamus-pituitary-adrenal cortex are closely related. This is a Chinese medicine, and the regulatory action of the neurotrophic fluid has an immunomodulatory effect.

Chinese medicine has the function of the corticosteroids inherently, licorice, ginseng leaf, rich, Astragalus, sewage, jade porridge. In addition, the corticosteroids inhibit the action, such as yellow gold, sugar ginseng. The doses of these drugs are not the same and do not have the same action and even show opposite effects. For example, draft malic acid increases the amount of cGMP in lymphocytes in small amounts and increases the amount of cAMP in large quantities. cGMP and cAMP are opposites in immune action. This results in a combination of laboratory tests and the use of herbal medicines for dialectic, which leads to immune regulation and favors equilibrium.

2) neuromodulation immunity

In clinical trials, there are patients with lung, nasal, and eminent patients. Especially, the unlicensed patients have excessively increased parasympathetic nerve function and immune function is too low. At this time, after administration of the bogganjaje to suppress the parasympathetic nerve and improve the immune function is not the same degree. These explanations are a painstaking prescription for plant nerves to trigger immune regulation.

3) Regulatory immunity of cGMP system

Maintaining cAMP and cGMP in normal cells has a certain ratio and level. When the proportion of cAMP and cGMP decreases, it indicates proportionality of ataxia and the body's immune function is abnormal. Such herbs include ginseng, Astragalus, and control, which increase the content of cAMP. The major contradiction point is the high cAMP content when humans neglect, and the contradiction point is lowered in proportion to cAMP and cGMP. Based on this, dialectic and yin and yang control in oriental medicine eventually leads to normal cAMP and cGMP content, and maintaining a constant proportionality brings equilibrium in immune regulation. Control of cAMP and cGMP system is called <Rapid control>.

4) Nucleic Acid Metabolic Regulatory Immunity

Diseases arising from aberrations of immune function in the clinic lead to the purpose of treatment by means of nucleic acid metabolism in performing immune modulation. When explaining drugs for modulating nucleic acid metabolism, it is interpreted as an immunomodulatory action. If Xinyang rich drug, broiler, age ratio, breeding to increase the rate of DNA degradation, moisturizing drugs such as Saenghwang, Hyunsam, Macmundong, old plate is lowering the rate of synthesis of DNA. Therefore, under the dialectical principle of oriental medicine, the control of yin and yang, especially the moan xinyang, is to regulate nucleic acid metabolism and thus to regulate immunity.

5) Increased cell yield and immune regulation

T cells are composed of T inhibitor cells and T helper cells. T inhibitory cells inhibit the secretion of B cells and their antibodies. This is to suppress the enhanced immune response. T helper cells secrete antibodies from other human antigens while assisting the secretion of B cells, and raise an excessively low response. In the example described above, Bosin's herb evenly increases the yield and mass of T cells, which triggers the action of regulatory immunity. In addition, T cells have the function of tyrosine, all of which have immune activity. Chinese herbal medicine also increases T cell yield and enhances T cell function. All these herbs protect the thymus and promote thymus secretion.

6) interregulatory and immune regulation of the body when drugs pass

According to the experiments, the live malic acid injections have an interaction when they have a sensitive delayed-type hypersensitivity reaction to BNCB, which also suppresses the intensity of the radical hypersensitivity reaction and also antagonizes and suppresses cellular immunity. In animal experiments, live malic acid significantly increases the equilibrium in myocardial DNA under hypoxia conditions, which is not seen in normal animals. The previously described negative herb does not have any intermodal action. When researching with Astragalus, Licorice and Ginseng, it has the effect of raising cAMP and cGMP in the plasma or tissue of experimental animals and defeating downward. The same type of drug produces two kinds of results, both of which are intermodulatory. According to the data of jade bottle (acid, wind, white licorice, licorice), the mouse spleen affects antibody-forming cells and interacts with the high and low immune state for sheep red blood cells. In other words, if the immune response is too high, the control is low, and if the immune response is too low, the control is high. (Pastor nami: Immunology and Oriental Medicine, Seoul, Open Books, 1992, p58-93.)

In the present invention, immunomodulatory agents having efficacy against long-term seawater due to persistent cold virus infection, and non-leucine bodies, atrophic gastritis, ulcerative diseases, etc. among the diseases related to immunity, which are clinically multiplied symptoms. And it aims at providing functional food.

In order to achieve the above object, according to the present invention, there is provided an immunomodulator comprising the extracts of baekhyang, baekchul and lobules, and a functional food containing the same extract.

Hereinafter, the content of the present invention in more detail, as follows.

Locusts and lobules are characteristically excellent medicines to treat fraud externally and internally to improve nausea discomfort. Lobules serve to improve the gas of the nasal passages, while the lobe serves to improve the bodies and gases of the nasal passages. As stated in the above paragraph, the human crisis occurs in the stomach, so when there is a pathological change in the stomach, it is difficult to produce a normal condition. The function is further degraded. Exodus has nothing to do with external soldiers. (Healthy creation has the function of releasing foreign affairs.) That is to improve the weakness of the internal nausea. There are many medicines to improve the weakness of the stomach, but it is a drug that can be used without exerting any side effects on the body's keratin and shows excellent effects. This medicine is the best medicine to recover chronic gastritis, atrophic gastritis, gastrointestinal disability, gastric sewage.

The combination of these medicines can further promote the production of crisis in the rain because it acts to improve the fluoride state of the nasal gastric function and activate the function of the lowered nasal gastric function. In addition, it is possible to actively treat external symptoms (long-term seawater, and lutein bodies) due to the deterioration of the crisis.

In the present invention, the main raw material (POGOSTEMONIS HERBA) is perennial herbaceous Pogostemon cablin (B _LANCO .) B _ENTH . Or dried or dried perennial herbaceous _vinegar Agastache rugosa (F _ISCH . Et M _EYER ) O. K _UNTZE , which is collected between June and July, and crushed or shaded; It is harvested in July and in October.

Gwakhyang is a dry stomach medicine, old wind medicine, fire extinguishing medicine, fever lowering medicine. It is used for eating heat, congestion, cold, headache, vomiting and diarrhea. It is also rarely used as a tumor drug. In particular, it is an important medicine used for the spleen and gastrointestinal diseases. (Interested by: Herbal Composition and Lyons, Pyongyang, Encyclopedia of Science Encyclopedia, 1984, p506.)

The antiviral agent (8-15%) has an inhibitory effect (antifungal action) against various pathogenic fungi, such as Schonlein ringworm, in vitro , and the antiviral agent (15 mg / ml) has an inhibitory effect on leptospira. . In order to kill leptospira, the concentration should be increased to 31mg / ml. (Antispiroheta action; Shin Mingyo, Yoo Seop-seop: Hyangjedae, Seoul, Yeonglimsa, 1998, p839-840)

The baekchul (Atractyloids Rhizoma alba) other medicinal ingredient of the present invention Asteraceae (菊花科; Compositae) perennial plant of baekchul belonging to: drying the rhizomes of _{(白朮Atractylodes macrocephala K OIDZ.} ) Or sapju (Atractylodes japonica K _OIDZ.) will be.

As a pretreatment, it is used first. This is because, if you use it, you can get rid of humidity, and if you use it, it will be dry.

Baekchul, the nasal secretion, helps the stomach (胃), and controls the rectum of the stomach. It cures anorexia, lethargy, scariness, diarrhea, diarrhea, edema, jaundice, urinary insufficiency, dizziness, birth anxiety, and pain caused by moistness. 1992, p 536.)

As a pharmacological action, it exhibits a distinct and persistent diuretic effect on various animals such as rats, rabbits, and dogs, and has a hypoglycemic effect because it accelerates assimilation of glucose in the body by perfusion of rats. The oral treatment of the mice acts to protect the liver and prevent the reduction of hepatic glycogen by CCl ₄ . When a healthy person took root spoons three times a day at a time, prothrombin time and coagulation time were significantly prolonged for four days and returned to normal only after ten days of discontinuation. Alcoholic extracts are also effective but have a short duration (anticoagulant action). Injecting 6 g / kg of lactose daily into the mouse for 1 month may promote the weight gain and strength gain of the mouse (swimming test; tonic action). Extraction of water also inhibits epidermoid fungi and nocardia spp. In vitro . (Shin Min-kyo et al .: Chinese Traditional Dictionary, Seoul, Jeongdam, 1998, p2217-2218.)

Perillae Herba is a perennial herb, Perilla frutescens (L.) B _RITT ., Or wrinkled leaf ( P. frutescenes (L.) B _RITT . Var. The leaves of crispa D _ECNE .) are dry. Use after removing miscellaneous materials and old man.

Leaflets scatter outside chills, rinse, and detoxify. Treats colds, Gicheon, chest bloating, and unstable anxiety. (Department of Primary School of Korean Medical University: Herbology, Seoul, Yeonglimsa, 1992, p126)

As a pharmacological action, the rabbits fevered with the TYPHUS mixed vaccine had a small antipyretic effect as a result of injecting 2 g / kg of Jaso Leaf Tea and acupuncture. In addition, the Korean fever extract was injected into the rabbit heated by warmth (자: ten thousand) had a relatively mild antipyretic effect (antipyretic effect). It also has an antimicrobial action that inhibits the growth of staphylococci in vitro. (Shinmingyo et al .: Chinese Traditional Dictionary, Seoul, Jeongdam, 1998, p4608-4609.)

The extracts of the rhomboid, baekchul and lobular leaves according to the present invention can be obtained by hot water extraction of a mixed medicinal mixture combining 15-20 parts by weight of baekchul and 15-20 parts by weight of lobule with respect to 100 parts by weight of baekhyang.

Externally, it is possible to treat wind and wind heat, and internally, it improves the condition of the stomach by improving the evaporation of the stomach. I use a lot of direction (100 parts by weight). And in order to enhance the effect on the stomach's nausea, it combines the baekchul to treat anorexia, lethargy, diarrhea and dizziness by looking at the stomach (15-20 parts by weight) To strengthen the effect of)], add a leaflet that has a function to disperse, chill and detoxify the outside chill (15 to 20 parts by weight). In addition, lobules because of the phenomenal action, and the eccentricity, the white out, and the internal and external trauma (內 外傷) is also meant to remove the pain.

In the case of hot water extraction, it is possible to extract the active ingredient from the three raw materials by the conventional hot water extraction method. That is, 30-100 L of water is added to 10 kg of the raw materials, and the mixture is boiled for 3-8 hours, preferably 3-5 hours while maintaining the temperature of 100 ± 5 ° C. under normal pressure, and then filtered to obtain an extract. The final extract is preferably in the range of 20-50 liters. At the time of extraction, it is preferable to throw in white leaves from the beginning, and to extract leaflets and leaves from 1 hour to 1 hour and 30 minutes before the end of extraction. Alternatively, the extract may be mixed after extracting each raw material.

A suitable organic solvent, for example, ethanol or the like can be used as the extraction solvent, and the obtained extract can be used as a powdered extract from which the solvent is removed by concentration.

In the case of hot water extract, 50-100cc is taken once as a medicine several times, preferably 3-5 times.

When the extract according to the present invention is concentrated and powdered, suitable formulations such as powders, granules, tablets, etc., together with excipients, preservatives, lubricants, stabilizers, emulsifiers, buffers, coloring agents, flavoring agents, etc. which are commonly used in pharmaceuticals , Capsules, gels for tubes, and the like.

Furthermore, various functional foods, such as beverages, old-fashioned drinks, drinks, confectionery, etc., containing the extracts of Kwak Hyang, baekchul and lobules of the present invention can be prepared.

For example, when preparing a functional beverage, distilled water may be added to the extraction stock solution or powdered extract powder, diluted, mixed with an additive normally added to the beverage, sterilized, and then commercialized according to a conventional beverage preparation method.

Drugs consisting of extracts of the leaves, baekchul and lobule obtained by the present invention is useful for regulating abnormal immune function, and particularly useful for the treatment and prevention of allergic rhinitis, cold and the like. In addition, since various functional foods containing the extract obtained by the present invention are always ingested, it is useful as a functional food for preventing colds and other immune regulation.

Next, the Example of this invention is described. However, these examples are provided to facilitate the understanding of the present invention, and the scope of the present invention is not limited to these examples.

Example 1

5 l of water was poured into the mixed medicinal herbs of Kwak Hyang, 0.15 kg Baekchul, and 0.2 kg of lobules, heated at 100 ° C. for 4 hours, and then filtered with gauze to obtain 3 L of extract. White medicinal herbs were added from the beginning, and lobules and lancets were added 1 hour before the end of extraction.

Example 2

5 L of water was poured into a mixed medicine of 1 kg of Kwak Hyang, 0.2 kg of Baekchul, and 0.15 kg of lobules, heated at 100 ° C. for 4 hours, and then filtered with gauze to obtain 3 L of an extract. White medicinal herbs were added from the beginning, and lobules and locusts were added 1 hour and 30 minutes before the end of extraction.

Example 3

5 L of water was poured into a mixed medicine of 1 kg of Kwak Hyang, 0.2 kg of Baekchul, and 0.2 kg of lobules, heated at 100 ° C. for 3 hours, decocted, and filtered with gauze to obtain 3.3 L of an extract. White medicinal herbs were added from the beginning, and lobules and lancets were added 1 hour before the end of extraction.

According to the present invention, it is useful to control abnormal immune function, and in particular, it is possible to obtain drugs and functional foods useful for the treatment and prevention of allergic rhinitis, cold, and the like.

Claims (3)

An immunomodulatory agent comprising extracts of kwak hyang, baekchul and lobules. The method of claim 1, Immunomodulator, characterized in that the extract is obtained by hot water extraction of a mixed medicinal mixture containing 15-20 parts by weight, 15-20 parts by weight of lobules, per 100 parts by weight of Kwak Hyang. Functional food for immunomodulation comprising the extract of Kwakhyang, baekchul and lobules.