KR20010093331A - 포유류의 생체 조직 내에서의 캡슐 형성을 위한폴리아크릴아미드 겔의 용도, 세포를 배양하는 방법, 및종양 질환과 당뇨병의 치료방법 - Google Patents
포유류의 생체 조직 내에서의 캡슐 형성을 위한폴리아크릴아미드 겔의 용도, 세포를 배양하는 방법, 및종양 질환과 당뇨병의 치료방법 Download PDFInfo
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- KR20010093331A KR20010093331A KR1020017009958A KR20017009958A KR20010093331A KR 20010093331 A KR20010093331 A KR 20010093331A KR 1020017009958 A KR1020017009958 A KR 1020017009958A KR 20017009958 A KR20017009958 A KR 20017009958A KR 20010093331 A KR20010093331 A KR 20010093331A
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/0012—Galenical forms characterised by the site of application
- A61K9/0019—Injectable compositions; Intramuscular, intravenous, arterial, subcutaneous administration; Compositions to be administered through the skin in an invasive manner
- A61K9/0024—Solid, semi-solid or solidifying implants, which are implanted or injected in body tissue
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
- A61K47/30—Macromolecular organic or inorganic compounds, e.g. inorganic polyphosphates
- A61K47/32—Macromolecular compounds obtained by reactions only involving carbon-to-carbon unsaturated bonds, e.g. carbomers, poly(meth)acrylates, or polyvinyl pyrrolidone
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/0012—Galenical forms characterised by the site of application
- A61K9/0019—Injectable compositions; Intramuscular, intravenous, arterial, subcutaneous administration; Compositions to be administered through the skin in an invasive manner
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P15/00—Drugs for genital or sexual disorders; Contraceptives
- A61P15/10—Drugs for genital or sexual disorders; Contraceptives for impotence
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P3/00—Drugs for disorders of the metabolism
- A61P3/08—Drugs for disorders of the metabolism for glucose homeostasis
- A61P3/10—Drugs for disorders of the metabolism for glucose homeostasis for hyperglycaemia, e.g. antidiabetics
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P5/00—Drugs for disorders of the endocrine system
- A61P5/48—Drugs for disorders of the endocrine system of the pancreatic hormones
- A61P5/50—Drugs for disorders of the endocrine system of the pancreatic hormones for increasing or potentiating the activity of insulin
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N5/00—Undifferentiated human, animal or plant cells, e.g. cell lines; Tissues; Cultivation or maintenance thereof; Culture media therefor
- C12N5/06—Animal cells or tissues; Human cells or tissues
- C12N5/0602—Vertebrate cells
- C12N5/0676—Pancreatic cells
- C12N5/0677—Three-dimensional culture, tissue culture or organ culture; Encapsulated cells
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K35/00—Medicinal preparations containing materials or reaction products thereof with undetermined constitution
- A61K35/12—Materials from mammals; Compositions comprising non-specified tissues or cells; Compositions comprising non-embryonic stem cells; Genetically modified cells
- A61K2035/126—Immunoprotecting barriers, e.g. jackets, diffusion chambers
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K35/00—Medicinal preparations containing materials or reaction products thereof with undetermined constitution
- A61K35/12—Materials from mammals; Compositions comprising non-specified tissues or cells; Compositions comprising non-embryonic stem cells; Genetically modified cells
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N2502/00—Coculture with; Conditioned medium produced by
- C12N2502/24—Genital tract cells, non-germinal cells from gonads
- C12N2502/243—Cells of the female genital tract, non-germinal ovarian cells
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N2502/00—Coculture with; Conditioned medium produced by
- C12N2502/30—Coculture with; Conditioned medium produced by tumour cells
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- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Engineering & Computer Science (AREA)
- General Health & Medical Sciences (AREA)
- Medicinal Chemistry (AREA)
- Pharmacology & Pharmacy (AREA)
- Veterinary Medicine (AREA)
- Public Health (AREA)
- Animal Behavior & Ethology (AREA)
- Biomedical Technology (AREA)
- Organic Chemistry (AREA)
- Epidemiology (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Biotechnology (AREA)
- Diabetes (AREA)
- Zoology (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Dermatology (AREA)
- General Chemical & Material Sciences (AREA)
- Wood Science & Technology (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Genetics & Genomics (AREA)
- Inorganic Chemistry (AREA)
- Endocrinology (AREA)
- Neurosurgery (AREA)
- Microbiology (AREA)
- Biochemistry (AREA)
- General Engineering & Computer Science (AREA)
- Cell Biology (AREA)
- Hematology (AREA)
- Emergency Medicine (AREA)
- Obesity (AREA)
- Gynecology & Obstetrics (AREA)
- Reproductive Health (AREA)
- Medicines Containing Material From Animals Or Micro-Organisms (AREA)
- Coloring Foods And Improving Nutritive Qualities (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Medicinal Preparation (AREA)
- Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
Abstract
Description
마우스 라인 | 종양주(tumor strain) | 흑색종의 성장 | 수명 | 전이 |
BALB/C+GEL | B-16 | + | 60일(관찰 기간) | - |
BALB/C | B-16 | - | >관찰기간 | - |
C57BLACK+GEL | SKMEL28 | + | >관찰기간 | - |
C57BLACK | SKMEL28 | - | >관찰기간** | - |
숫자 | 종양주 | 종양 발현 시간 | 마우스의 수명 | 전이의 존재 |
1 | BALB/C 라인의 겔 유래 흑색종(B-16-X) | 30일 | 60일 | + |
2 | B-16(대조군) | 7일 | 22일 | + |
숫자 | 종양주 | 종양 발현 시간 | 동물의 사망 |
5 | B-16 | - | >60일 |
6 | B-16 | 7-15일 | 18-20일 |
Claims (11)
- 생체에서의 부재나 결핍이 질병을 유도하고/거나 생체에서의 양의 증가가 병변을 겪고 있는 생체의 상태를 향상시키는데 공헌하는 생물학적 활성 성분을 생산하기 위해 의도된 동물의 자가 혹은 외인성 이식 세포를 장기간의 시간동안 배양하기 위해 의도된 캡슐을 포유류의 생체조직 내에서 형성시키기 위한 폴리아크릴아미드 겔의 용도.
- 제 1 항에 있어서, 상기 생체가 인간 생체인 것을 특징으로 하는 용도.
- 제 2 항에 있어서, 상기 병변이 당뇨병인 것을 특징으로 하는 용도.
- 제 1 항 내지 3 항 중 어느 한 항에 있어서, 상기 이식세포가 췌장 β-세포인 것을 특징으로 하는 용도.
- 제 4 항에 있어서, 상기 췌장세포가 신생 토끼 혹은 어린 돼지의 세포인 것을 특징으로 하는 용도.
- 포유류에게 폴리아크릴아미드 겔을 미리 투여한 뒤 상기 겔에 포유류의 이종유래 혹은 자가 세포를 주입함으로써 살아 있는 생체 내에서 장기간의 시간동안 포유류의 이종유래의 세포를 배양하고 변형시킨 후 상기 세포를 백신 제제를 제조하기 위해 사용하는 방법.
- 제 6 항에 있어서, 상기 이종유래의 세포로서 종양세포를 사용하는 것을 특징으로 하는 방법.
- 제 6 항에 있어서, 상기 이종유래의 세포로서 레이디히 세포를 사용하는 것을 특징으로 하는 방법.
- 제 6 항 내지 9항 중 어느 한 항에 있어서, 상기 세포의 변형은 그 증식 활성의 저하와 생체에 대한 면역화 효과에 있는 것을 특징으로 하는 방법.
- 수여체에게 미리 폴리아크릴아미드 겔을 투여한 후, 치료학적으로 상당한 양의 췌장 β세포를 상기 겔에 이식하는 방법에 의해 당뇨병을 치료하는 방법.
- 제 10 항에 있어서, 상기 β-세포가 신생 토끼 혹은 어린돼지의 세포인 것을 특징으로 하는 방법.
Applications Claiming Priority (5)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
RU99125349 | 1999-12-08 | ||
RU99125349A RU2152800C1 (ru) | 1999-12-08 | 1999-12-08 | Способ культивирования и модификации гетерогенных клеток млекопитающих |
RU2000116208 | 2000-06-23 | ||
RU2000116208A RU2165263C1 (ru) | 2000-06-23 | 2000-06-23 | Способ лечения сахарного диабета |
PCT/RU2000/000477 WO2001041809A1 (fr) | 1999-12-08 | 2000-11-22 | Utilisation d'un gel polyacrilamide pour former une capsule dans un tissu d'un mammalien, procede de culture de cellules et procede de traitement des maladies oncologiques et du diabete sucre |
Publications (1)
Publication Number | Publication Date |
---|---|
KR20010093331A true KR20010093331A (ko) | 2001-10-27 |
Family
ID=26654029
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
KR1020017009958A Ceased KR20010093331A (ko) | 1999-12-08 | 2000-11-22 | 포유류의 생체 조직 내에서의 캡슐 형성을 위한폴리아크릴아미드 겔의 용도, 세포를 배양하는 방법, 및종양 질환과 당뇨병의 치료방법 |
Country Status (9)
Country | Link |
---|---|
US (1) | US6972194B1 (ko) |
EP (1) | EP1151756B1 (ko) |
JP (1) | JP2003516364A (ko) |
KR (1) | KR20010093331A (ko) |
CN (1) | CN100408098C (ko) |
AT (1) | ATE355083T1 (ko) |
CA (1) | CA2361563A1 (ko) |
DE (1) | DE60033633T2 (ko) |
WO (1) | WO2001041809A1 (ko) |
Families Citing this family (3)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
RU2165263C1 (ru) * | 2000-06-23 | 2001-04-20 | Зыбин Дмитрий Владимирович | Способ лечения сахарного диабета |
IL163941A0 (en) * | 2002-04-10 | 2005-12-18 | Obschestvo S Ogranichennoy Otv | Polyfunctional biocompatible hydrogel and method for the production thereof |
WO2016205434A1 (en) | 2015-06-16 | 2016-12-22 | University Of Florida Research Foundation, Incorporated | Virb10 for vaccination against gram negative bacteria |
Family Cites Families (16)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
SU977466A1 (ru) * | 1979-11-06 | 1982-11-30 | Киевский Ордена Трудового Красного Знамени Медицинский Институт Им.Акад.А.А.Богомольца | Полиакриламидный гель дл медико-биологических целей и способ его получени |
GB2114578B (en) * | 1979-11-06 | 1984-06-27 | Ki Med I | Polyacrylamide gel for medical and biological application and method of its preparation |
US4353888A (en) * | 1980-12-23 | 1982-10-12 | Sefton Michael V | Encapsulation of live animal cells |
NO158284C (no) * | 1981-03-13 | 1988-08-17 | Damon Biotech Inc | Fremgangsmaate for selektiv oppbrytning av en permeabel membran. |
JPH03266980A (ja) * | 1989-03-16 | 1991-11-27 | W R Grace & Co | 細胞培養用基材およびそれを用いた細胞集合体の製造方法 |
JPH0382472A (ja) * | 1989-08-28 | 1991-04-08 | Terumo Corp | 生体内長期埋植材及びその製造方法 |
JP3035719B2 (ja) | 1991-06-27 | 2000-04-24 | 日本バイリーン株式会社 | 多孔質シートの製造方法 |
RU2026643C1 (ru) | 1992-12-25 | 1995-01-20 | Зыбин Дмитрий Владимирович | Способ лечения больных с нарушением мужской половой функции методом трансплантации |
UA10911C2 (uk) * | 1994-08-10 | 1996-12-25 | Мале Впроваджувальне Підприємство "Іhтерфалл" | Біосумісhий гідрогель |
RU2090185C1 (ru) * | 1994-09-30 | 1997-09-20 | Минаев Б.Д. | Микрокапсула |
US5827707A (en) * | 1995-06-07 | 1998-10-27 | Neocrin Company | Method for manufacturing minimal volume capsules containing biological materials |
GB9516556D0 (en) * | 1995-08-12 | 1995-10-11 | Smith & Nephew | Cell culture laminate |
BG102375A (en) * | 1997-08-26 | 1999-11-30 | Пегас Оод | Inoculation biocompatible hydrophilic gel, method for its preparation and application |
RU2135193C1 (ru) | 1997-10-28 | 1999-08-27 | Скалецкий Николай Николаевич | Способ получения материала, содержащего бета-клетки поджелудочной железы, для трансплантации больным сахарным диабетом с использованием феномена миграции клеток, материал, содержащий бета-клетки поджелудочной железы, для трансплантации больным сахарным диабетом и способ лечения сахарного диабета методом его трансплантации |
CA2330104A1 (en) * | 1998-04-09 | 1999-10-21 | Charlotte-Mecklenberg Hospital Authority | Creation of three-dimensional tissues |
WO2000064977A1 (en) * | 1999-04-26 | 2000-11-02 | California Institute Of Technology | In situ forming hydrogels |
-
2000
- 2000-11-22 EP EP00981961A patent/EP1151756B1/en not_active Expired - Lifetime
- 2000-11-22 WO PCT/RU2000/000477 patent/WO2001041809A1/ru active IP Right Grant
- 2000-11-22 CA CA002361563A patent/CA2361563A1/en not_active Abandoned
- 2000-11-22 DE DE60033633T patent/DE60033633T2/de not_active Expired - Fee Related
- 2000-11-22 JP JP2001543153A patent/JP2003516364A/ja active Pending
- 2000-11-22 US US09/890,496 patent/US6972194B1/en not_active Expired - Fee Related
- 2000-11-22 KR KR1020017009958A patent/KR20010093331A/ko not_active Ceased
- 2000-11-22 AT AT00981961T patent/ATE355083T1/de not_active IP Right Cessation
- 2000-11-22 CN CNB008035644A patent/CN100408098C/zh not_active Expired - Fee Related
Also Published As
Publication number | Publication date |
---|---|
CA2361563A1 (en) | 2001-06-14 |
JP2003516364A (ja) | 2003-05-13 |
EP1151756B1 (en) | 2007-02-28 |
US6972194B1 (en) | 2005-12-06 |
ATE355083T1 (de) | 2006-03-15 |
DE60033633D1 (de) | 2007-04-12 |
CN100408098C (zh) | 2008-08-06 |
EP1151756A4 (en) | 2004-05-12 |
CN1339971A (zh) | 2002-03-13 |
WO2001041809A1 (fr) | 2001-06-14 |
EP1151756A1 (en) | 2001-11-07 |
DE60033633T2 (de) | 2007-11-15 |
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