KR102777587B1 - Cosmetic Composition for Harmful Rays Screening - Google Patents

Abstract

The present invention relates to a cosmetic composition for blocking harmful visible light, and more specifically, to a cosmetic composition effective in blocking violet light and blue light. When a cosmetic composition containing the organic ultraviolet ray blocking ingredient of the present invention as an effective ingredient is applied, it is possible to specifically block light in the violet light range of 380 to 430 nm and the blue light range of 430 to 500 nm, which were difficult to block in the past, thereby protecting the skin.

Description

{Cosmetic Composition for Harmful Rays Screening}

This application claims the benefit of priority to Korean Patent Application No. 10-2016-0024036, filed February 29, 2016, the entire contents of which are incorporated herein by reference.

The present invention relates to a cosmetic composition for blocking harmful visible light, and more specifically, to a cosmetic composition effective in blocking violet light and blue light.

Generally, when we say 'light', we mean visible light (380 to 780 nm), which is the range that can be seen by the human eye, among various electromagnetic waves. Blue light is usually light with a wavelength of 380 to 500 nm, and it means light with the shortest wavelength and strongest energy among visible light that can be seen by humans, that is, light that reaches the retina. More specifically, the 380 to 430 nm range is called violet light, and the 430 to 500 nm range is called blue light.

Little is known about the effects of light of wavelengths other than ultraviolet (e.g. visible light) on human skin, but recently, violet light and blue light have been investigated for their harmful effects on skin.

According to a paper published in relation to this (THE JOURNAL OF BIOLOGICAL CHEMISTRY Vol. 280, No. 22, Issue of June 3, pp. 21061-21066, 2005 "Blue Light Induces Mitochondrial DNA Damage and Free Radical Production in Epithelial Cell"), blue light damages mitochondrial DNA in epithelial cells and generates reactive oxygen species (ROS), causing cell dysfunction, cell aging, and tumorigenesis.

In addition, another paper (Journal of Investigative Dermatology (2010) 130, 259 ~ 269 "Blue-Light Irradiation Regulates Proliferation and Differentiation in Human Skin Cells") reported that light with a wavelength of 412 ~ 453 nm regulates the proliferation and differentiation of keratinocytes and skin-derived endothelial cells, and another paper (PLoS One. 2013 Sep 17;8(9)e73678 "Violet Light Down-Regulates the Expression of Specific Differentiation Markers through Rhodopsin in Normal Human Epidermal Keratinocytes") reported that violet light (410 nm) in the blue light range overexpresses mRNA of rhodopsin, one of the photoreceptors expressed in keratinocytes of the skin, and CREB (cAMP It has been reported that it reduces the phosphorylation of keratinocyte-responsive element-binding protein (KRP), decreases the mRNA expression levels of Keratin-10 (K10) and Keratin-1 (K1), which are differentiation markers of specific keratinocytes, thereby decreasing the differentiation of human keratinocytes and delaying the recovery of damaged skin barrier.

In addition to the effects on the skin reported above, blue light suppresses the secretion of melatonin, which induces sleep, and increases the secretion of serotonin, which induces wakefulness, thereby causing sleep disorders. In addition, it reaches the retina directly and induces the production of melanin, causing the skin to become dull and develop freckles.

Since these violet lights and blue lights are especially abundant in LED displays and LED lights such as smartphones, laptops, and monitors, which are necessities for modern people, and since contact with them is inevitable in the living environment of modern society, attempts to block them are being made in various ways. However, among these many attempts, there has been no disclosure or teaching regarding the blue light blocking effect of ultraviolet ray blocking ingredients. Therefore, the inventors of the present invention have discovered, after a long period of research, that a specific combination of ultraviolet ray blocking ingredients is effective in blocking blue light, and have thus arrived at the present invention.

THE JOURNAL OF BIOLOGICAL CHEMISTRY Vol. 280, no. 22, Issue of June 3, pp. 21061-21066, 2005 "Blue Light Induces Mitochondrial DNA Damage and Free Radical Production in Epithelial Cell" Journal of Investigative Dermatology (2010) 130, 259 ~ 269 "Blue-Light Irradiation Regulates Proliferation and Differentiation in Human Skin Cells" PLoS One. 2013 Sep 17;8(9)e73678 "Violet Light Down-Regulates the Expression of Specific Differentiation Markers through Rhodopsin in Normal Human Epidermal Keratinocytes"

Solar energy mainly comes to the Earth as electromagnetic waves, and these electromagnetic waves include all wavelengths of radiation, including radio waves, microwaves, infrared rays, visible light, ultraviolet rays, x-rays, and γ-rays in that order from longest wavelength. Many sunscreen products developed to protect the skin from sunlight (solar energy) are focused on preventing skin damage caused by the UVB range (290 to 320 nm) and UVA range (320 to 400 nm). However, the proportion of ultraviolet rays in sunlight is very small, and in regions other than ultraviolet rays, it is known that visible light contained in sunlight, especially blue light and violet light with a wavelength of 380 to 500 nm, causes the most skin damage. Accordingly, the inventors of the present invention developed a cosmetic product that can block not only ultraviolet rays but also blue/violet light, which is a visible light range that is harmful to the skin.

The present invention provides a cosmetic composition for blocking harmful visible light, characterized in that it comprises bis-ethylhexyloxypheno methoxyphenyl triazine and diethylamino hydroxybenzoyl hexyl benzoate. The composition may further comprise zinc oxide (ZnO).

By applying the cosmetic composition according to the present invention, it is possible to specifically block light in the violet light range of 380 to 430 nm and the blue light range of 430 to 500 nm, which were difficult to block in the past, thereby protecting the skin.

Unless otherwise defined, the technical and scientific terms used in this specification have the meaning commonly understood by a person of ordinary skill in the art to which this invention belongs. Therefore, repeated explanations of the same technical configuration and operation as in the prior art will be omitted.

The present invention relates to a cosmetic composition for blocking harmful visible light, and more specifically, to a cosmetic composition effective in blocking violet light and blue light. In the present specification, harmful visible light includes violet light having a wavelength of 380 to 430 nm and blue light having a wavelength of 430 to 500 nm.

The present invention provides a cosmetic composition containing as an effective ingredient a combination of bis-ethylhexyloxypheno methoxyphenyl triazine and diethylamino hydroxybenzoyl hexyl benzoate, which exhibit excellent blocking effects against violet light and blue light.

The above bis-ethylhexyloxyphenol methoxyphenyl triazine and the above diethylaminohydroxybenzoylhexyl benzoate are a type of organic UV-blocking ingredient, and as a functional raw material notified by the Ministry of Food and Drug Safety, the above bis-ethylhexyloxyphenol methoxyphenyl triazine is an organic UV-blocking ingredient that acts on both ultraviolet-B and ultraviolet-A regions, and diethylaminohydroxybenzoylhexyl benzoate is known to be an organic UV-blocking ingredient that is effective on ultraviolet-A.

Ultraviolet rays can be divided into ultraviolet-C (UVC) with a wavelength of 100 to 280 nm, ultraviolet-B (UVB) with a wavelength of 280 to 315 nm, and ultraviolet-A (UVA) with a wavelength of 315 to 380 nm. The organic ultraviolet-blocking ingredients described above have been manufactured and contained as ingredients of functional cosmetics primarily for the purpose of blocking ultraviolet-A and ultraviolet-B rays.

However, as the harmful effects of violet light with a wavelength of 380 to 430 nm and blue light with a wavelength of 430 to 500 nm on the skin have been proven in the visible light range, attempts have been made to develop cosmetic compositions that block these.

The present invention has discovered that among numerous ultraviolet ray blocking ingredients, a combination of the bis-ethylhexyloxyphenol methoxyphenyl triazine and the diethylaminohydroxybenzoylhexyl benzoate has a blocking effect against harmful visible light.

Organic UV blocking ingredients usually work by absorbing the energy of ultraviolet rays that reach the skin. Since using the organic UV blocking ingredients above the standard level can cause skin irritation, their use is limited, and many ingredients mainly absorb ultraviolet B rays.

Bis-ethylhexyloxyphenol methoxyphenyl triazine and diethylaminohydroxybenzoyl hexyl benzoate according to the present invention are known as components that mainly absorb ultraviolet A rays, which are relatively long wavelength ranges, among organic ultraviolet ray blocking components, and therefore can be expected to have a blocking effect on violet light and blue light, which are short wavelength ranges among the visible light ranges.

According to the present invention, Bis-Ethylhexyloxypheno Methoxyphenyl Triazine may be included in an amount of 1 to 10 wt% based on 100 wt% of the total cosmetic composition. If the content of the bis-ethylhexyloxypheno Methoxyphenyl Triazine is less than 1 wt%, the harmful visible light blocking effect may be minimal, and if it exceeds 10 wt%, skin irritation may occur. Considering the harmful visible light blocking effect and minimizing skin irritation, the content of the bis-ethylhexyloxyphenol methoxyphenyl triazine may be preferably 2 to 7 wt%, and more preferably 3 to 5 wt%.

In addition, the Diethylamino Hydroxybenzoyl Hexyl Benzoate may be included in an amount of 1 to 10 wt% of the total cosmetic composition 100 wt%. If the content of the Diethylamino Hydroxybenzoyl Hexyl Benzoate is less than 1 wt%, the harmful visible light blocking effect may be minimal, and if it exceeds 10 wt%, it may cause skin irritation. Considering the harmful visible light blocking effect and minimizing skin irritation, the content of the Diethylamino Hydroxybenzoyl Hexyl Benzoate may be preferably 2 to 7 wt%, and more preferably 3 to 5 wt%.

In addition, the cosmetic composition for blocking harmful visible light according to the present invention may further contain zinc oxide (ZnO). The zinc oxide is a type of inorganic ultraviolet ray blocking ingredient, and is effective in blocking ultraviolet ray, particularly ultraviolet ray A, by physically scattering ultraviolet ray reaching the skin.

At this time, the zinc oxide is included in an amount of 3 to 15 wt% of the total cosmetic composition (100 wt%), so as to further enhance the harmful visible light blocking effect. If the content of the zinc oxide is less than 3 wt%, the improvement in the harmful visible light blocking effect is minimal, and if it exceeds 15 wt%, skin irritation or a whitening phenomenon may occur, which may not be good in terms of usability or appearance. Considering such an improvement in the harmful UV-ray blocking effect and prevention of the whitening phenomenon, the content of the zinc oxide may be preferably 5 to 12 wt%, and more preferably 7 to 10 wt%.

The weight ratio of the above bis-ethylhexyloxyphenol methoxyphenyl triazine, diethylaminohydroxybenzoylhexyl benzoate and zinc oxide may be 1:0.5 to 5:0.5 to 5, preferably 1:0.7 to 4:0.7 to 4, and more preferably 1:0.8 to 2:0.8 to 2.

At this time, if the weight ratio of the bis-ethylhexyloxyphenol methoxyphenyl triazine and diethylaminohydroxybenzoylhexyl benzoate is less than 1:0.5 or more than 1:5, the harmful visible light blocking effect may be reduced.

In addition, if the weight ratio of the bis-ethylhexyloxyphenol methoxyphenyl triazine and zinc oxide is less than 1:0.5, the harmful visible light blocking effect may be reduced, and if it exceeds 1:5, skin irritation or a white clouding phenomenon may occur. In particular, the closer the weight ratio of the bis-ethylhexyloxyphenol methoxyphenyl triazine and zinc oxide is to an equal weight ratio, the more the skin harmful visible light blocking effect is improved while simultaneously minimizing skin irritation.

The cosmetic composition for blocking harmful visible light according to the present invention can be manufactured in any formulation commonly manufactured in the art, and for example, can be formulated in various forms such as a solution, a suspension, an emulsion, a paste, a cream, a toner, an essence, a foam, a pack, a soap, an oil, a gel, a spray, a powder, a wax, a balm, etc., and for example, can be formulated in the form of a skin lotion, a skin softener, a skin toner, an astringent, a lotion, a milk lotion, a moisture lotion, a nutrition lotion, a cream, a massage cream, a nutrition cream, a moisture cream, a hand cream, a foundation, an essence, a nutrition essence, a pack, a soap, a cleansing foam, a cleansing lotion, a cleansing cream, a body cream, a body lotion, a body oil, a body essence, a body cleanser, a sun cream, a sun gel, a sun lotion, etc.

In addition, the cosmetic composition according to the present invention may contain adjuvants commonly used in the fields of cosmetology or dermatology, such as fatty substances, organic solvents, solubilizers, thickeners, gelling agents, emollients, antioxidants, suspending agents, stabilizers, foaming agents, fragrances, surfactants, water, ionic or nonionic emulsifiers, fillers, sequestering agents, chelating agents, preservatives, vitamins, blocking agents, humectants, essential oils, dyes, pigments, hydrophilic or lipophilic active agents, lipid vesicles or any other ingredients commonly used in cosmetics. The adjuvants are introduced in an amount commonly used in the fields of cosmetology or dermatology.

When the above formulation is a paste, cream or gel, animal oil, vegetable oil, wax, paraffin, starch, tragacanth, cellulose derivatives, polyethylene glycol, silicone, bentonite, silica, talc or zinc oxide may be used as a carrier component.

If the above formulation is a powder or spray, lactose, talc, silica, aluminum hydroxide, calcium silicate or polyamide powder may be used as a carrier component, and particularly in the case of a spray, a propellant such as chlorofluorohydrocarbon, propane/butane or dimethyl ether may be additionally included.

When the above formulation is a solution or emulsion, a solvent, a solubilizing agent or an emulsifying agent is used as a carrier component, and examples thereof include water, ethanol, isopropanol, ethyl carbonate, ethyl acetate, benzyl alcohol, benzyl benzoate, propylene glycol, 1,3-butyl glycol oil, glycerol aliphatic esters, polyethylene glycol or fatty acid esters of sorbitan.

When the above formulation is a suspension, liquid diluents such as water, ethanol or propylene glycol, suspending agents such as ethoxylated isostearin alcohol, polyoxyethylene sorbitol ester and polyoxyethylene sorbitan ester, microcrystalline cellulose, aluminum metahydroxide, bentonite, agar or tragacanth may be used as carrier components.

Hereinafter, the present invention will be described in more detail with specific examples. However, the present invention is not limited to the following examples, and it will be apparent to those skilled in the art that various modifications or changes can be made within the technical scope of the present invention.

According to the compositions described in [Table 1] and [Table 2] below, oil-in-water (O/W) cosmetic compositions were prepared by the methods described in the examples and comparative examples below. The contents in [Table 1] and [Table 2] are all in weight %.

Raw material name Content (weight%) Organic sunscreen Ethylhexyl Methoxycinnamate See Table 2 below Isoamyl p-methoxycinnamate Bisethylhexyloxyphenol methoxyphenyl triazine
(Bis-Ethylhexyloxyphenol Methoxyphenyl Triazine) Diethylaminohydroxybenzoylhexyl benzoate
(Diethylamino Hydroxybenzoyl Hexyl Benzoate) Weapon sunscreen Zinc oxide
(Zinc Oxide) Paid Glyceryl Stearate/PEG-100 Stearate
(Glyceryl Stearate/PEG-100 Stearate) 2 Glyceryl Stearate 0.7 C12-15 Alkyl Benzoate 5 Behenyl Alcohol 1.5 premier Purified water to 100 Disodium EDTA 0.05 Butylene Glycol 10 Phenoxyethanol 1 Emulsifier Polyacrylate-13/Polyisobutene/Polysorbate 20
(Polyacrylate-13/Polyisobutene/Polysorbate 20) 1.5

　 Raw material name Comparative Example 1 Comparative Example 2 Comparative Example 3 Comparative Example 4 Comparative Example 5 Example 1 Example 2 Organic sunscreen Ethylhexyl methoxycinnamate
(EthylhexylMethoxycinnamate) 4.5 4.5 - - - - - Isoamyl p-methoxycinnamate
(Isoamylp-methoxycinnamate) 4.5 - 4.5 - - - - Bisethylhexyloxyphenol methoxyphenyl triazine
(Bis-EthylhexyloxyphenolMethoxyphenylTriazine) - 4.5 - 9 - 4.5 3 Diethylaminohydroxybenzoylhexyl benzoate
(DiethylaminoHydroxybenzoylHexylBenzoate) - - 4.5 - 9 4.5 3 Weapon UV Blocker ZnO (zinc oxide) - - - - - - 3

<Example 1>

A first mixture was prepared by mixing the organic UV-blocking agent, oily agent, and emulsifier described in Tables 1 and 2 at 75°C. At this time, the organic UV-blocking agent contains diethylaminohydroxybenzoylhexyl benzoate and bis-ethylhexyloxyphenol methoxyphenyl triazine, each in an amount of 4.5 wt% based on the total weight of the cosmetic composition.

A second mixture was prepared by adding all aqueous components to purified water at 75°C and mixing them.

The first mixture was dispersed using a homogenizer, and the obtained dispersion was added to the second mixture and emulsified using a homogenizer to prepare an oil-in-water (O/W) cosmetic composition.

<Example 2>

An oil-in-water (O/W) cosmetic composition was prepared in the same manner as in Example 1, containing 3 wt% each of organic UV-blocking components, diethylaminohydroxybenzoylhexyl benzoate, bis-ethylhexyloxyphenol methoxyphenyl triazine, and inorganic UV-blocking component, zinc oxide, based on the total weight of the cosmetic composition.

<Comparative Example 1>

An oil-in-water (O/W) cosmetic composition was prepared in the same manner as in Example 1, containing 4.5 wt% each of ethylhexyl methoxycinnamate and isoamyl p-methoxycinnamate as organic UV-blocking ingredients based on the total weight of the cosmetic.

<Comparative Example 2>

An oil-in-water (O/W) cosmetic composition was prepared in the same manner as in Example 1, containing 4.5 wt% of each of ethylhexyl methoxycinnamate and bis-ethylhexyloxyphenol methoxyphenyl triazine as organic UV-blocking ingredients, based on the total weight of the cosmetic.

<Comparative Example 3>

An oil-in-water (O/W) cosmetic composition was prepared in the same manner as in Example 1, containing 4.5 wt% each of isoamyl p-methoxycinnamate and diethylaminohydroxybenzoylhexyl benzoate as organic UV-blocking ingredients based on the total weight of the cosmetic.

<Comparative Example 4>

An oil-in-water (O/W) cosmetic composition was prepared in the same manner as in Example 1, but containing 9 wt% of bis-ethylhexyloxyphenol methoxyphenyl triazine as an organic UV-blocking agent based on the total weight of the cosmetic.

<Comparative Example 5>

An oil-in-water (O/W) cosmetic composition was prepared in the same manner as in Example 1, but containing 9 wt% of diethylaminohydroxybenzoylhexyl benzoate as an organic UV-blocking agent based on the total weight of the cosmetic.

<Experimental Example 1> Test of blue light and violet light blocking effect

In order to confirm the blue/violet light blocking effect of the cosmetic compositions of Examples 1 and 2 and Comparative Examples 1 to 5 manufactured according to the compositions of Tables 1 and 2 above, the formulations of Examples and Comparative Examples were applied in an amount of 2 mg/cm ² on quartz or a band-pass filter, respectively, and then a light source including the blue light/violet region was irradiated, and the transmitted blue/violet light wavelength region (400 to 500 nm) was measured using an SPR-4001 spectroradiometer (Spectroradiometer, Luzchem, Cancada).

The following [Table 3] shows the test results for the measured violet light blocking rate and blue light blocking rate.

　 Comparative Example 1 Comparative Example 2 Comparative Example 3 Comparative Example 4 Comparative Example 5 Example 1 Example 2 Violet Light
Block rate 0% 17% 19% 33% 38% 45% 55% Blue light
Block rate 0% 9% 11% 18% 20% 28% 38%

Referring to Table 3 above, first, Comparative Example 1 had no effect at all in blocking violet light and blue light, and Comparative Examples 2 and 3 did not show values that significantly blocked them. Comparative Examples 4 and 5 also showed a slight increase in blocking rate compared to Comparative Examples 2 and 3, but did not show a satisfactory blocking effect.

Meanwhile, Example 1 showed improved violet light blocking rate and blue light blocking rate compared to Comparative Examples 2 to 5, confirming that the harmful visible light blocking rate, which is the purpose of the present invention, was increased overall. In addition, in the case of Example 2, the violet light blocking rate was improved by about 20% and the blue light blocking rate was improved by about 30% compared to Example 1, showing that it most effectively blocks harmful visible light, which is the purpose of the present invention.

Therefore, it was confirmed that a combination of bis-ethylhexyloxyphenol methoxyphenyl triazine and diethylaminohydroxybenzoylhexyl benzoate as essential ingredients, and appropriate combination of zinc oxide, can effectively block violet light and blue light.

Claims (9)

Contains Bis-Ethylhexyloxyphenol Methoxyphenyl Triazine, Diethylamino Hydroxybenzoyl Hexyl Benzoate and Zinc Oxide (ZnO).
The weight ratio of the above bis-ethylhexyloxyphenol methoxyphenyl triazine, diethylaminohydroxybenzoylhexyl benzoate and zinc oxide is 1:1 to 2:1 to 2,
The above bis-ethylhexyloxyphenol methoxyphenyl triazine is contained in an amount of 1 to 10 wt% of the total cosmetic composition,
The above diethylaminohydroxybenzoylhexyl benzoate is included in an amount of 1 to 10 wt% of the total cosmetic composition 100 wt%,
The above zinc oxide is included in an amount of 3 to 15 wt% of the total cosmetic composition of 100 wt%,
An oil-in-water (O/W) cosmetic composition for blocking harmful visible light, characterized in that it blocks harmful visible light, namely violet light with a wavelength of 380 to 430 nm and blue light with a wavelength of 430 to 500 nm. delete delete delete delete delete delete delete delete