KR102700424B1 - Neckband-type bacterial and viral disease management device - Google Patents

Abstract

A neckband-type bacterial and viral disease management device is disclosed. According to one embodiment, a neckband-type bacterial and viral disease management device may include: an electrical stimulation generating unit that sequentially generates electrical stimulations of different frequencies; a band unit that is worn around a user's neck; and an electrode unit that is arranged on an inner surface of the band unit and contacts the neck of a user having a bacterial disease or a viral disease to sequentially apply the generated electrical stimulations of different frequencies to the neck of the user.

Description

Neckband-type bacterial and viral disease management device

Relates to a neckband-type device for managing bacterial and viral diseases using electrical stimulation.

Viruses are infectious agents made up of genetic material made up of DNA or RNA and proteins. The size varies depending on the type, but is usually between 10 and 1000 nm. Since they cannot metabolize on their own, they infiltrate their own DNA or RNA into host cells such as bacteria, animals, and plants, and then use the host cell organelles to replicate them and produce viruses similar to themselves, which usually destroys the host cell.

Despite human defense (immune response), the mutation rate of bacteria and viruses is remarkably fast, so new bacteria and viruses are continuously emerging, and it is difficult to develop treatments and vaccines to treat diseases caused by them. Therefore, until a vaccine is developed, conservative treatment is inevitable, and many casualties occur as a result. Therefore, the need for a treatment device that can primarily kill or reduce bacteria and viruses that have invaded the body by using a specific combination of current, voltage, frequency, waveform, and current flow time is increasing.

Patent Registration No. 10-1061009 (August 25, 2011)

The purpose is to provide a neckband-type device for managing bacterial and viral diseases using electrical stimulation.

A neckband-type bacterial and viral disease management device according to one aspect comprises: an electrical stimulation generating unit that sequentially generates electrical stimulations of different frequencies; a band unit that is worn around a user's neck; and an electrode unit that is arranged on an inner surface of the band unit and contacts the neck of a user having a bacterial disease or a viral disease to sequentially apply the generated electrical stimulations of different frequencies to the neck of the user.

The above electrode unit includes a first electrode contacting the skin on the side of the first vagus nerve; and a second electrode contacting the skin on the side of the second vagus nerve.

The above neckband-type bacterial and viral disease management device further includes a pendant connected to the band portion; and the electric stimulation generating portion is disposed on the pendant.

The above-mentioned electric stimulation generating unit is placed on the outer surface of the back of the neck of the above-mentioned band unit.

The above bacterial or viral diseases include rhinitis.

The above electric stimulation includes voltage or current, the voltage is greater than 0 and less than or equal to 300 V, the current is greater than 0 and less than or equal to 20 mA, the frequency of the electric stimulation is greater than or equal to 1 Hz and less than or equal to 100 GHz, the duration of each frequency is greater than or equal to 1 minute and less than or equal to 20 minutes, and the waveform of the electric stimulation is one or a combination of two or more of direct current, alternating current, and pulsation.

The above-mentioned electric stimulation generating unit sequentially generates electric stimulations of different frequencies by referring to a previously stored frequency list.

The above-mentioned neckband-type bacterial and viral disease management device further includes a sensor part arranged on the inner surface of the band part to measure the temperature or humidity of the user's neck.

The above-described neckband-type bacterial and viral disease management device further includes a control unit that stops the operation of the electric stimulation generating unit if the measured temperature or humidity is above a set level.

The above bacterial diseases include diseases caused by any one of the following bacteria: Streptococcus pneumoniae, Streptococcus pyogenes, Streptococcus nephrodisiac, Streptococcus brucellosis, Escherichia coli, Mycobacterium tuberculosis, Streptococcus typhi, Streptococcus cholerae, syphilis, Staphylococcus aureus, Staphylococcus aureus, and Salmonella.

The above viral diseases include diseases caused by any one of human papillomavirus, Ebola virus, coronavirus, SARS virus, measles virus, human immunodeficiency virus (HIV), Japanese encephalitis virus, hepatitis A, B, C virus, herpes virus, rabies virus, influenza virus, rhinovirus, respiratory syncytial virus, influenza virus, Zika virus, West Nile virus, smallpox virus, and polio virus.

By sequentially applying electrical stimulation of different frequencies to the neck of a user with a bacterial or viral disease, bacteria and viruses that have invaded the user's body can be killed or reduced.

By sequentially delivering microcurrents of different frequency bands to the important nerves in the neck area, bacterial and viral diseases can be managed quickly and efficiently.

FIGS. 1 and 2 are schematic drawings illustrating a neckband-type bacterial and viral disease management device according to an exemplary embodiment.
FIG. 3 is a block diagram of a neckband-type bacterial and viral disease management device according to an exemplary embodiment.
Figure 4 is a drawing showing the results of an experiment conducted according to Experimental Example 1.

Hereinafter, an embodiment of the present invention will be described in detail with reference to the attached drawings. When adding reference numerals to components in each drawing, it should be noted that the same components are given the same numerals as much as possible even if they are shown in different drawings. In addition, when describing the present invention, if it is determined that a specific description of a related known function or configuration may unnecessarily obscure the gist of the present invention, the detailed description thereof will be omitted.

Meanwhile, for each step, each step may occur in a different order than stated, unless the context clearly states a specific order. That is, each step may be performed in the same order as stated, may be performed substantially simultaneously, or may be performed in the opposite order.

The terms described below are terms defined in consideration of their functions in the present invention, and may vary depending on the intention or custom of the user or operator. Therefore, their definitions should be made based on the contents throughout this specification.

Although the terms first, second, etc. may be used to describe various components, the components should not be limited by the terms. The terms are used only to distinguish one component from another. The singular expression includes the plural expression unless the context clearly indicates otherwise, and it should be understood that the terms "comprises" or "has" are intended to specify the presence of a feature, number, step, operation, component, part, or combination thereof described in the specification, but do not exclude the possibility of the presence or addition of one or more other features, numbers, steps, operations, components, parts, or combinations thereof.

In addition, the division of components in this specification is only a division by the main function of each component. In other words, two or more components may be combined into one component, or one component may be divided into two or more by more detailed functions. In addition to its own main function, each component may additionally perform some or all of the functions of other components, and some of the main functions of each component may be performed exclusively by other components. Each component may be implemented by hardware or software, or by a combination of hardware and software.

FIG. 1 and FIG. 2 are schematic drawings of a neckband-type bacterial and viral disease management device according to an exemplary embodiment, and FIG. 3 is a block diagram of a neckband-type bacterial and viral disease management device according to an exemplary embodiment.

Referring to FIGS. 1 to 3, a neckband-type bacterial and viral disease management device (100) (hereinafter, disease management device) may include a band portion (110), a main body portion (120), and an electrode portion (130).

The band part (110) may be formed in the form of a wearable device that is worn around the user's neck and comes into contact with the user's neck, for example, in the form of a neckband.

According to an exemplary embodiment, the band portion (110) may include an elastic material to facilitate wearing by the user. In addition, the band portion (110) may include a length adjustment means such as a button, buckle, or Velcro that can adjust the length while wrapping around the user's neck.

According to an exemplary embodiment, the band portion (110) may include a separate cushion material that can function as a cushion to reduce skin irritation when worn. The cushion material allows the user to wear the band portion (110) for a long period of time without discomfort.

The electrode part (130) may be placed on the inner surface of the band part (110). For example, the electrode part (130) may be placed so as to be exposed toward the user's neck on the inner surface of the band part (110). In this way, when the user wears the band part (110), the electrode part (130) may naturally come into contact with the user's neck.

According to an exemplary embodiment, the electrode portion (130) may be positioned so that it can naturally come into contact with the user's skin on the side of the vagus nerve when the user wears the band portion (110).

According to an exemplary embodiment, the electrode unit (130) may include a plurality of electrodes that contact different skin areas of the user. For example, the electrode unit (130) may include a first electrode (131) that contacts the skin on the side of the first vagus nerve and a second electrode (132) that contacts the skin on the side of the second vagus nerve. Each electrode (131, 132) may be made of a conductive material through which electricity can flow, such as a conductive fiber, a conductive metal, a conductive rubber, and a conductive plastic.

The electrode part (130) can apply electrical stimulation to the neck of a user having a bacterial or viral disease by coming into contact with the neck of the user. Here, the electrical stimulation includes voltage or current, and a microcurrent of less than 1000㎂ can be transmitted to the neck of the user through the electrical stimulation, and the microcurrent can be transmitted to the vagus nerve, phrenic nerve, and trigeminal nerve through the neck of the user.

The bacterial or viral disease may include rhinitis. In addition, the bacterial disease may include diseases caused by, for example, Streptococcus pneumoniae, Streptococcus pyogenes, Streptococcus nephriticus, Streptococcus cholerae, Streptococcus syphilis, Staphylococcus aureus, Staphylococcus aureus, and Salmonella, and the viral disease may include diseases caused by, for example, human papillomavirus, Ebola virus, coronavirus, SARS virus, measles virus, human immunodeficiency virus (HIV), Japanese encephalitis virus, hepatitis A, B, C virus, herpes virus, rabies virus, influenza virus, rhino virus, respiratory syncytial virus (RSV), influenza virus, Zika virus, West Nile virus, smallpox virus, and polio virus. Here, the human papillomavirus may include, for example, HPV types include HPV 6, HPV 11, HPV 16, HPV 18, HPV 31, HPV 33, HPV 45, HPV 52, and HPV 58, and coronaviruses may include, for example, SARS-CoV, MERS-CoV, SARS-CoV-2, and SARS-like-CoV.

The main body (120) may include an electric stimulation generating unit (210) and a control unit (220).

The electric stimulation generating unit (210) can sequentially generate electric stimulation of different frequencies under the control of the control unit (220) and transmit them to the electrode unit (130). At this time, the voltage is greater than 0 and less than or equal to 300 V, the current is greater than 0 and less than or equal to 20 mA, the frequency is greater than or equal to 1 Hz and less than or equal to 100 GHz, and the duration of each frequency can be greater than or equal to 1 minute and less than or equal to 20 minutes. The waveform of the electric stimulation can be one of direct current, alternating current, and pulse (monophasic or biphasic), or a combination of two or more.

According to one embodiment, the electric stimulation generating unit (210) can use a previously stored frequency list. In this case, the electric stimulation generating unit (210) can sequentially and repeatedly generate electric stimulation of each frequency in the frequency list.

For example, it is assumed that three frequencies (the first frequency to the third frequency) are registered in the frequency list and the duration of the electric stimulation of each frequency is 1 minute. In this case, the electric stimulation generating unit (210) can generate an electric stimulation of the first frequency for 1 minute and transmit it to the electrode unit (130), then generate an electric stimulation of the second frequency for 1 minute and transmit it to the electrode unit (130), then generate an electric stimulation of the third frequency for 1 minute and transmit it to the electrode unit (130), and then generate an electric stimulation of the first frequency for 1 minute and transmit it to the electrode unit (130). In this way, the electric stimulation of each frequency in the frequency list can be sequentially and repeatedly generated and applied to the user through the electrode unit (130).

Meanwhile, the electric stimulation generating unit (210) can generate electric stimulation using a power source or battery provided inside or outside the main body (120).

The control unit (220) can control the overall operation of the main body (120). In addition, the control unit (220) can perform various operations performed in the main body (120) and process data. In addition, the control unit (220) can be configured to drive an operating system (OS), an application, etc. for driving the main body (120). For example, when a user's command or a predetermined event occurs, the control unit (220) can control the electric stimulation generation unit (210) to sequentially generate electric stimulations of different frequencies and transmit them to the electrode unit (130).

According to an exemplary embodiment, the main body (120) may be placed on the outer surface of the band (110) (e.g., the outer surface at the back of the neck) (see FIG. 1) or may be placed inside the pendant (140) connected to the band (100) (see FIG. 2). However, this is only one embodiment, and the position of the main body (120) may be changed in various ways.

The main body (120) may further include an input unit (230), a storage unit (240), a communication unit (250), and an output unit (260).

The input unit (230) can receive various operation signals and information from the user. According to one embodiment, the input unit (230) can include a key pad, a dome switch, a touch pad, a jog wheel, a jog switch, a H/W button, etc. In particular, when the touch pad forms a mutual layer structure with the display, it can be called a touch screen.

The storage unit (240) can store programs or commands for the operation of the main body unit (120), and can store data input/output to the main body unit (120), processed data, etc. For example, the storage unit (240) can store information necessary for generating electric stimulation used for managing bacterial or viral diseases, such as voltage magnitude, current magnitude, frequency list, duration of each frequency, electric stimulation waveform (e.g., direct current, alternating current, pulse (monophasic or biphasic), etc.).

The storage unit (240) may include at least one type of storage medium, such as a flash memory type, a hard disk type, a multimedia card micro type, a card type memory (e.g., an SD or XD memory, etc.), a Random Access Memory (RAM), a Static Random Access Memory (SRAM), a Read Only Memory (ROM), an Electrically Erasable Programmable Read Only Memory (EEPROM), a Programmable Read Only Memory (PROM), a magnetic memory, a magnetic disk, an optical disk, etc. In addition, the main body (120) may operate an external storage medium, such as a web storage that performs the storage function of the storage unit (240) on the Internet.

The communication unit (250) can perform communication with an external device. For example, the communication unit (250) can transmit data input into the main body (120), stored data, processed data, etc. to an external device, or receive various data to be used for bacterial disease or viral disease management from an external device.

The communication unit (250) can communicate with an external device using wired or wireless communication technology. At this time, the wireless communication technology may include, but is not limited to, Bluetooth communication, BLE (Bluetooth Low Energy) communication, Near Field Communication (NFC), WLAN communication, Zigbee communication, Infrared Data Association (IrDA) communication, WFD (Wi-Fi Direct) communication, UWB (ultra-wideband) communication, Ant+ communication, WIFI communication, RFID (Radio Frequency Identification) communication, 3G communication, 4G communication, and 5G communication. However, these are only examples and are not limited thereto.

The output unit (260) can output data input to the main body (120), stored data, processed data, etc. According to one embodiment, the output unit (260) can output information on electrical stimulation applied to the user (e.g., voltage magnitude, current magnitude, frequency, duration of each frequency, waveform), etc., by at least one of an auditory method, a visual method, and a tactile method. To this end, the output unit (260) can include a display, a speaker, a vibrator, etc.

The disease management device (100) may further include a first sensor unit (150) and a second sensor unit (160).

The first sensor unit (150) can measure environmental information of the user's skin. Here, the environmental information can include temperature and humidity, etc. To this end, the first sensor unit (150) can include a temperature sensor and a humidity sensor, etc.

If the electrode unit (130) is in contact with the user's body surface, i.e., the skin, for a long period of time, the skin temperature may rise or sweat may be discharged from the skin, so that the desired microcurrent may not be properly transmitted to the user's body. Accordingly, if heat and sweat are generated from the user's body and at least one of the temperature and humidity measured by the first sensor unit (150) is above a set level, the control unit (220) may stop the operation of the electric stimulus generation unit (210) or notify the user through the output unit (260) that the measurement value of the first sensor unit (150) is above a set level.

The second sensor unit (160) can measure bio-signals by coming into contact with the user's body. Here, the bio-signals can include body temperature, heartbeat, pulse, blood pressure, electrocardiogram, etc. To this end, the second sensor unit (160) can include a body temperature sensor, a heartbeat sensor, a pulse sensor, a blood pressure sensor, an electrocardiogram sensor, etc. The user's bio-signals measured by the second sensor unit (160) can be transmitted to an external device through the communication unit (250) and used to monitor the user's health status.

The first sensor unit (150) and the second sensor unit (160) may be arranged on the inner surface of the band unit (110). For example, the first sensor unit (150) and the second sensor unit (160) may be arranged so as to be exposed toward the user's neck on the inner surface of the band unit (110). As a result, when the user wears the band unit (110), the first sensor unit (150) and the second sensor unit (160) may naturally come into contact with the user's neck.

According to a disease management device (100) according to one embodiment, by sequentially transmitting microcurrents of different frequency bands to important nerves in the neck area, bacteria and viruses can be effectively killed, so that bacterial diseases and viral diseases can be quickly and efficiently managed.

[Experimental Example 1]

E. coli strains were cultured overnight, colonies were suspended in PBS (phosphate buffer saline) to adjust the OD ₆₀₀ to 0.5, and 2 ml was dispensed into two plates (plate 1 and plate 2).

No electrical stimulation was applied to the first plate, and the second plate was subjected to the following electrical stimulation for 70 minutes.

-condition-

(1) Voltage is greater than 0 and less than 14 V, (2) Frequency is referenced in the frequency list in Table 1 below, (3) Duration of each frequency is 1 minute, (4) Waveform is single-phase pulsating wave

order Frequency (Hz) 1 145.9 2 165.7 3 331.4 4 437.6 5 497.1 6 583.5 7 662.7 8 1167.0 9 1312.8 10 1325.5

Samples from each plate were harvested, diluted 10-fold in 0.45% saline, and the diluted samples were cultured overnight in TSA (Tryptone soy media) medium, and the colony number was counted to calculate cfu (colony forming units) per ml, resulting in the results shown in Figure 4.

Referring to Figure 4, it can be confirmed that E. coli bacteria are significantly reduced in the case where electric stimulation is applied (J1) compared to the case where electric stimulation is not applied (Control).

[Experimental Example 2] - Measurement of virus titers

Picornavirus (enterovirus) was used as the target virus, and the virus titer was expressed as the 50% tissue culture infectious dose (TCID50).

By applying electrical stimulation under the same conditions as Experimental Example 1 for 60 minutes, the following Table 2 was obtained. Referring to this, it can be confirmed that the Log10 TCID50/ml value was significantly reduced in the case where electrical stimulation was applied (C1) compared to the case where electrical stimulation was not applied (Control).

PEV titers (Log10 TCID50/ml) C1 1.5 Control 5.5

[Experimental Example 3] - Verification of rhinitis effect

The same electrical stimulation conditions as in Experimental Example 1 were applied to 10 rhinitis patients for 40 minutes, and the changes in the intensity of rhinitis felt by each rhinitis patient were confirmed, as shown in Table 3 below. Referring to this, it can be confirmed that rhinitis symptoms are alleviated when electrical stimulation is applied. (In Table 3 below, the intensity of rhinitis felt is in 11 stages (0 to 10), and a higher number means more severe rhinitis.)

The intensity of feeling rhinitis Before the experiment After the experiment Patient 1 8 2 Patient 2 4 2 Patient 3 7 3 Patient 4 7 4 Patient 5 9 3 Patient 6 8 3 Patient 7 5 3 Patient 8 9 3 Patient 9 4 3 Patient 10 4 2

The above-described embodiments can be implemented as computer-readable codes on a computer-readable recording medium. The computer-readable recording medium can include all kinds of recording devices that store data that can be read by a computer system. Examples of the computer-readable recording medium can include ROMs, RAMs, CD-ROMs, magnetic tapes, floppy disks, optical disks, etc. In addition, the computer-readable recording medium can be distributed over network-connected computer systems, and can be written and executed as computer-readable codes in a distributed manner.

The present invention has been described so far with reference to preferred embodiments thereof. Those skilled in the art will understand that the present invention can be implemented in modified forms without departing from the essential characteristics of the present invention. Accordingly, the scope of the present invention should not be limited to the above-described embodiments, but should be interpreted to include various embodiments within a scope equivalent to the contents described in the claims.

100: Disease Control Device
110: Band Club
120: Main body
130: Electrode section
140: Pendant
150: 1st sensor section
160: 2nd sensor section
210: Electrical stimulation generating unit
220: Control Unit
230: Input section
240: Storage
250: Communications Department
260: Output section

Claims (11)

An electrical stimulation generating unit that sequentially generates electrical stimulation of different frequencies including three or more single-phase pulsating waves or alternating current waves among the frequencies of 145.9 Hz, 165.7 Hz, 331.4 Hz, 437.6 Hz, 497.1 Hz, 583.5 Hz, 662.7 Hz, 1167.0 Hz, 1312.8 Hz, and 1325.5 Hz;
A band worn around the user's neck;
An electrode part arranged on the inner surface of the band part and contacting the neck of a user having a bacterial or viral disease to sequentially apply electrical stimulation of different frequencies generated above to the neck of the user;
A first sensor unit arranged on the inner surface of the band unit and configured to measure the skin temperature of an area of the user's neck in contact with the electrode unit;
A second sensor unit configured to measure the body temperature of the user; and
A control unit that stops the operation of the electric stimulation generating unit when the skin temperature measured through the first sensor unit is above a set level;
The above bacterial or viral disease is at least one of a disease caused by a picornavirus, which is an RNA virus, a disease caused by E. coli, and rhinitis.
Neckband-type bacterial and viral disease control device. In the first paragraph,
The above electrode part,
A first electrode contacting the skin on the side of the first vagus nerve; and
a second electrode contacting the skin on the side of the second vagus nerve;
Neckband-type bacterial and viral disease control device. In the first paragraph,
Further comprising a pendant connected to the above band portion;
The above electric stimulation generating unit is placed on the pendant.
Neckband-type bacterial and viral disease control device. In the first paragraph,
The above electric stimulation generating unit is placed on the outer surface of the back of the neck of the band unit.
Neckband-type bacterial and viral disease control device. delete In the first paragraph,
The above electric stimulation includes voltage or current, the voltage is greater than 0 and less than or equal to 300 V, the current is greater than 0 and less than or equal to 20 mA, the frequency of the electric stimulation is greater than or equal to 1 Hz and less than or equal to 100 GHz, the duration of each frequency is greater than or equal to 1 minute and less than or equal to 20 minutes, and the waveform of the electric stimulation is one or a combination of two or more of waveforms further including direct current.
Neckband-type bacterial and viral disease control device. In the first paragraph,
The above electric stimulation generating unit sequentially generates electric stimulation of different frequencies by referring to a previously stored frequency list.
Neckband-type bacterial and viral disease control device. In the first paragraph,
The first sensor part is arranged on the inner surface of the band part and configured to measure the humidity of the user's neck.
Neckband-type bacterial and viral disease control device. In Article 8,
The above control unit stops the operation of the electric stimulation generating unit if the measured humidity is above a set level.
Neckband-type bacterial and viral disease control device. delete delete

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