KR102677418B1 - Active ingredient complex for alleviating skin irritation comprising high concentration of active ingredient - Google Patents

Abstract

The present invention provides an active ingredient complex for relieving skin irritation that contains a high concentration of the active ingredient in an aqueous solution and has high stability without phase separation such as precipitation, and a method for manufacturing the same.

Description

Active ingredient complex for alleviating skin irritation comprising high concentration of active ingredient and manufacturing method thereof {Active ingredient complex for alleviating skin irritation comprising high concentration of active ingredient}

The present invention relates to an active ingredient complex for relieving skin irritation containing a high concentration of active ingredients and a method for producing the same.

Inflammatory skin disease begins with the body's defense mechanism to prevent skin damage caused by physical stimulation, chemicals, bacteria, etc., and is caused by the production of interleukin-8 (IL-8) and interleukin-1β (Interleukin-1β). , IL-1β), prostaglandin E ₂ (prostaglandin E ₂ , PGE ₂ ), and TNF-α are involved in various inflammation-causing factors. In addition, unhealthy skin causes excessive moisture evaporation due to breakdown of the skin barrier, Because it is easily exposed to external stimuli, various inflammatory reactions such as allergic reactions, itching, erythema, and skin aging are triggered.

Meanwhile, synthetic pharmaceuticals such as ibuprofen, antihistamines, steroids, cortisone, immunosuppressants, and immunostimulants are currently mainly used to prevent and treat inflammatory skin diseases. However, this treatment not only provides temporary or simple symptom relief, but also has many side effects such as hypersensitivity reactions and deterioration of the immune system, and has limitations in fundamentally treating inflammation.

As a way to solve this problem, research is continuing on substances that have an inhibitory effect on various inflammation-causing factors and simultaneously have a moisturizing effect by strengthening the skin barrier, as well as cosmetics and pharmaceutical compositions using the same. However, the efficacy is not sufficient or there are skin safety issues, and even if the efficacy and skin safety are excellent, the solubility in water is poor, so when applied to the actual product, it must be included in a low content below the effective concentration, making it difficult to achieve practical effects. There are limits.

In other words, the development of new materials that simultaneously satisfy excellent inflammation-causing factor inhibition efficacy, skin moisturizing effect, water solubility, and safety is required.

Republic of Korea Patent Publication No. 10-2308743 (2021.09.28.)

The purpose of the present invention is to provide an active ingredient complex for alleviating skin irritation that contains a high concentration of the active ingredient in an aqueous solution and has high stability without phase separation such as precipitation, and a method for producing the same.

More specifically, the aim is to provide an economical manufacturing method that can maintain a stable phase while containing high concentrations of different active ingredients in an aqueous solution through a simple process without requiring expensive processes.

Another object of the present invention is to provide an active ingredient complex for relieving skin irritation that can relieve various skin irritations that occur when the skin is exposed to harmful external environments and chemicals and can achieve excellent anti-inflammatory and moisturizing effects.

For the above-described purpose, one aspect of the present invention includes the steps of complexing betaine and madecassoside in an aqueous solution to prepare a first complex aqueous solution; Preparing a second complex aqueous solution by adding and solubilizing allantoin to the first complex aqueous solution; and dissolving an aliphatic polyhydric alcohol and an alicyclic polyhydric alcohol in the second aqueous complex solution.

The aliphatic polyhydric alcohol and cycloaliphatic polyhydric alcohol may be moisturizing active ingredients.

It may further include adding mucopolysaccharide extracted from seaweed to the second complex aqueous solution.

In addition, one aspect of the present invention is a first complex aqueous solution in which betaine and madecassoside are complexed with each other; An aqueous solution of the second complex in which allantoin is solubilized in the hydrophobic core of the first complex; and an aliphatic polyhydric alcohol and an alicyclic polyhydric alcohol; provided is an active ingredient complex for alleviating skin irritation.

The active ingredient complex for alleviating skin irritation according to one aspect may further include mucous polysaccharide extracted from seaweed.

The betaine and madecassoside may be electrostatically complexed.

Madecassoside may be included in an amount of 1 to 20 parts by weight based on 100 parts by weight of betaine.

Allantoin may be included in an amount of 1 to 30 parts by weight based on 100 parts by weight of betaine.

The total weight of aliphatic polyhydric alcohol and cycloaliphatic polyhydric alcohol may be included in 50 to 200 parts by weight based on 100 parts by weight of betaine.

In addition, one aspect of the present invention provides a cosmetic composition for alleviating skin irritation, comprising the above-described complex of active ingredients for alleviating skin irritation.

The method for producing an active ingredient complex for alleviating skin irritation according to the present invention can provide an active ingredient complex for alleviating skin irritation that contains a high concentration of the active ingredient in an aqueous solution and has high stability without phase separation such as precipitation.

In addition, the active ingredient complex for alleviating skin irritation according to the present invention contains active ingredients stably at a high concentration in an aqueous solution, so it can be usefully used as a cosmetic base that can be used by adding small amounts to various cosmetic compositions. It can provide high stability without precipitation of active ingredients in the contained cosmetic composition.

In addition, the active ingredient complex for relieving skin irritation according to the present invention has excellent anti-inflammatory and moisturizing effects, so it has immediate effect in improving skin troubles and redness, and has excellent safety for the human body, making it useful in the prevention and treatment of various inflammatory skin diseases. can be used

Figure 1 shows the results of evaluating the skin irritation relief efficacy.

Unless otherwise defined herein, all technical and scientific terms have the same meaning as commonly understood by a person skilled in the art to which the present invention pertains. The terminology used in the description herein is merely to effectively describe particular embodiments and is not intended to limit the invention.

As used herein, the singular forms “a,” “an,” and “the” are intended to include the plural forms as well, unless the context clearly dictates otherwise.

In addition, the numerical range used in this specification includes the lower limit and upper limit and all values within the range, increments logically derived from the shape and width of the defined range, all double-defined values, and the upper limit of the numerical range defined in different forms. and all possible combinations of the lower bounds. Unless otherwise specified herein, values outside the numerical range that may occur due to experimental error or rounding of values are also included in the defined numerical range.

The term “comprises” in this specification is an open description with the same meaning as expressions such as “comprises,” “contains,” “has,” or “features,” and includes elements that are not additionally listed; Does not exclude materials or processes.

As used herein, the term “solubilization” refers to the phenomenon of increasing the solubility of a substance that is poorly soluble in water due to the presence of a substance such as a surfactant.

The term “extract” in this specification also includes crude extract or fractions obtained by additional fractionation of the extract. It includes not only those obtained using an extraction solvent, but also those obtained by additionally applying a purification process. .

Hereinafter, the present invention will be described in detail.

The present invention provides a manufacturing method that can provide an active ingredient complex for alleviating skin irritation that contains a high concentration of active ingredients in an aqueous solution and has high stability without phase separation such as precipitation.

Specifically, a method for producing an active ingredient complex for relieving skin irritation according to one aspect includes the steps of complexing betaine and madecassoside in an aqueous solution to prepare a first complex aqueous solution; Preparing a second complex aqueous solution by adding and solubilizing allantoin to the first complex aqueous solution; and adding and dissolving an aliphatic polyhydric alcohol and an alicyclic polyhydric alcohol in the second complex aqueous solution.

Among the active ingredients of the complex, madecassoside and allantoin have been proven to be excellent substances for relieving skin irritation and anti-inflammation, but their water solubility is very low, causing recrystallization or precipitation and making it difficult to contain them in high concentrations. However, the present invention can provide a complex containing a high concentration of madecassoside and allantoin in an aqueous solution by using the above-described manufacturing method, and using this, a cosmetic composition with excellent stability and skin irritation alleviation effect is produced. can be provided.

In addition, the method for producing an active ingredient complex for alleviating skin irritation according to one aspect may further include adding mucous polysaccharide extracted from seaweed to the second complex aqueous solution.

Specifically, a method for producing an active ingredient complex for relieving skin irritation according to one aspect includes the steps of complexing betaine and madecassoside in an aqueous solution to prepare a first complex aqueous solution; Preparing a second complex aqueous solution by adding and solubilizing allantoin to the first complex aqueous solution; and sequentially adding and dissolving aliphatic polyhydric alcohol, cycloaliphatic polyhydric alcohol, and mucous polysaccharide extracted from seaweed into the second complex aqueous solution.

For example, if the input order and composition combination of the above-described manufacturing method are not satisfied, stability may be significantly reduced and recrystallization and precipitation may occur.

Additionally, one aspect of the present invention provides an active ingredient complex for alleviating skin irritation.

Specifically, the active ingredient complex for relieving skin irritation according to one aspect includes a first complex aqueous solution in which betaine and madecassoside are complexed with each other; An aqueous solution of the second complex in which allantoin is solubilized in the hydrophobic core of the first complex; and aliphatic polyhydric alcohol and cycloaliphatic polyhydric alcohol.

The active ingredient complex for relieving skin irritation according to one aspect has the composition combination as described above, so it can contain a high concentration of the active ingredient in an aqueous solution and have high stability without phase separation such as precipitation, and has excellent skin irritation. A mitigation effect can be realized.

Specifically, betaine, madecassoside, and allantoin included in the complex of idle ingredients for relieving skin irritation are all substances with excellent anti-inflammatory or moisturizing effects, and can achieve an excellent skin irritation relieving effect through the synergistic effect of the combination of components. You can. In addition, madecassoside and allantoin are substances with very low water solubility, but betaine and madecassoside are electrostatically complexed to form a first complex, and as allantoin is solubilized in the hydrophobic core of the first complex, madecassoside It can significantly improve the water solubility of and allantoin at the same time.

In addition, the aliphatic polyhydric alcohol and alicyclic polyhydric alcohol may be moisturizing active ingredients and may provide a synergistic effect with the first complex and the second complex in improving stability and alleviating skin irritation.

The alicyclic polyhydric alcohol can be used without limitation as long as it is an alicyclic polyhydric alcohol that has a skin moisturizing effect. For example, it may be trehalose. In addition, the aliphatic polyhydric alcohol can be used without limitation as long as it has a skin moisturizing effect. For example, it may be panthenol (Dexpanthenol).

In the mucous polysaccharide extracted from the seaweed, the seaweed can be used without limitation as long as it contains a large amount of mucilage, but for example, native red algae such as seaweed and purple seaweed (Bangiophycidae; Protoflorideophycidae), agar, agar, etc. This may be red algae including the genus Florideophycidae, Gloiopeltis tenax, etc., and more specifically, grasshoppers may be used, but are not limited thereto.

Additionally, the mucous polysaccharide may be a hot water extract or a solvent extract, and specifically may be an extract extracted with an aqueous alcohol solution. The extraction method of the mucous polysaccharide can be prepared by a method known in the art, and the method is not particularly limited. A non-limiting example includes adding dried and pulverized seaweed to water, an organic solvent, or a mixture thereof and stirring to obtain an extract; It can be prepared by filtering and concentrating the extract, and can also be prepared in powder form by additional processes such as reduced pressure distillation and freeze-drying or spray-drying.

The active ingredient complex for relieving skin irritation according to one embodiment may include 1 to 20 parts by weight, 1 to 10 parts by weight, or 5 to 10 parts by weight of madecassoside based on 100 parts by weight of betaine. Additionally, allantoin may be included in an amount of 1 to 30 parts by weight, or 1 to 20 parts by weight, or 1 to 10 parts by weight, based on 100 parts by weight of the betaine. In addition, the total weight of the aliphatic polyhydric alcohol and the cycloaliphatic polyhydric alcohol may be 50 to 200 parts by weight, or 100 to 200 parts by weight, or 120 to 200 parts by weight, based on 100 parts by weight of the betaine. In addition, the active ingredient complex for alleviating skin irritation according to one embodiment includes 100 to 300 parts by weight, or 100 to 200 parts by weight, or 150 to 200 parts by weight, of mucous polysaccharide extracted from seaweed, based on 100 parts by weight of betaine. It may be possible. By satisfying the above-mentioned composition, the simultaneous improvement effect of stability and skin irritation alleviation effect can be further improved.

In addition, the active ingredient complex for alleviating skin irritation may contain 10 to 30% by weight, or 15 to 30% by weight, or 18 to 30% by weight, of the active ingredient based on the total weight of the aqueous solution. In other words, the active ingredient complex for relieving skin irritation according to one aspect contains the active ingredient stably at a high concentration and can be usefully used as a cosmetic base that can be used by adding a small amount to various cosmetic compositions. Cosmetics containing the cosmetic base It can provide high stability without precipitation of active ingredients in the composition.

One aspect of the present invention provides a cosmetic composition for alleviating skin irritation, comprising the above-described complex of active ingredients for alleviating skin irritation.

The cosmetic composition for alleviating skin irritation according to one aspect contains the complex of active ingredients for alleviating skin irritation, and thus has an immediate effect in improving skin troubles and redness, and has excellent stability to the human body, preventing and treating various inflammatory skin diseases. It can be usefully used.

Based on the total weight of the cosmetic composition for alleviating skin irritation according to one embodiment, the active ingredient complex for alleviating skin irritation may be included in an amount of 0.01 to 10% by weight, specifically 0.01 to 5% by weight, and more specifically 0.1 to 2% by weight. may be included. When the complex is included in the above-mentioned range, skin irritation relieving effect and skin safety can be further improved without compromising the stability of the formulation.

The cosmetic composition according to one aspect may be formulated into a general emulsified formulation, a solubilized formulation, etc., using commonly known manufacturing methods. As an example, the cosmetic composition is from the group consisting of lotion, cream, essence, lotion, gel, serum, foam, cleansing water, mask pack, powder, body cleanser, shampoo, rinse, hairdresser, hair tonic, ointment, patch, and spray. It may be formulated in any one selected formulation, but is not limited thereto.

In addition, the cosmetic composition may further include additional additives as appropriate depending on the purpose. In addition to the active ingredient complex for alleviating skin irritation according to the present invention, ingredients for improving wrinkles, antioxidant ingredients, and whitening ingredients are known in the art. It may further include ingredients selected from ingredients, etc. For example, it may be selected from retinoic acid, TGF, protein derived from animal placenta, betulinic acid, and chlorella extract, but is not limited thereto.

In addition, the cosmetic composition includes stabilizers, emulsifiers, thickeners, moisturizers, liquid crystal film strengtheners, pH adjusters, antibacterial agents, water-soluble polymers, coating agents, metal ion sequestrants, amino acids, organic amines, polymer emulsions, pH adjusters, skin nutrients, and oxidation agents. One or more water-based additives selected from antioxidants, antioxidant aids, preservatives, fragrances, etc.; and one or more oil-based additives selected from fats and oils, waxes, hydrocarbon oils, higher fatty acid oils, higher alcohols, synthetic ester oils, and silicone oils.

At this time, each of the additives may be included in an amount of 0.001 to 20% by weight, specifically 0.01 to 10% by weight and 0.05 to 5% by weight, based on the total weight of the cosmetic composition, but is not limited thereto.

Hereinafter, the above-described implementation example will be described in more detail through examples. However, the following examples are for illustrative purposes only and do not limit the scope of rights.

<Manufacture of composite>

[Example 1]

Betaine and madecassoside were added to purified water and mixed at room temperature for 30 minutes to prepare a first complex aqueous solution. Then, allantoin was added to the first complex aqueous solution and mixed for 60 minutes, and panthenol, trihalose and seaweed mucus were added. The active ingredient complex for alleviating skin irritation of Example 1 was prepared by sequentially adding and dissolving the polysaccharides. The amount of each raw material used was set to the composition ratio shown in Table 1 below.

[Example 2 and 3]

The same procedure as Example 1 was carried out, except that the amount of each raw material used was changed to the composition ratio shown in Table 1 below.

[Comparative Example 1]

Each raw material was added simultaneously in the composition ratio shown in Table 1 below and mixed for 120 minutes at room temperature.

[Comparative Examples 2 and 3]

The same procedure as Example 1 was carried out, except that the amount of each raw material used was changed to the composition ratio shown in Table 1 below.

Furtherance
(weight%) Example 1 Example 2 Example 3 Comparative Example 1 Comparative example 2 Comparative Example 3 Betaine 5 5 3 5 0 5 Matecassoside 0.5 0.2 0.2 0.5 0.5 0 allantoin One 0.5 0.1 One One One panthenol 5 3 3 5 5 5 trihalose 5 3 3 5 5 5 seaweed
mucinous polysaccharide 10 10 10 10 10 10 Purified water remaining amount remaining amount remaining amount remaining amount remaining amount remaining amount total 100 100 100 100 100 100

<Manufacture of cosmetic composition>

[Example 4 and Comparative Example 4]

The cosmetic compositions of Example 4 and Comparative Example 4 were prepared by mixing the compositions shown in Table 2 below.

Raw material name Example 4 (% by weight) Comparative Example 4 (% by weight) Complex of Example 1 2 0 beeswax 10 10 Polysorbate 60 1.5 1.5 PEG 60 hydrogenated castor oil 2 2 Sorbitan sesquioleate 0.5 0.5 liquid paraffin 10 10 squalane 5 5 Caprylic/Capric Triglyceride 5 5 glycerin 5 5 Butylene glycol 3 3 propylene glycol 3 3 Tromethamine 0.2 0.2 Preservatives, colors, fragrances Appropriate amount Appropriate amount Purified water remaining amount remaining amount total 100 100

<Evaluation example>

Evaluation 1. Solubility evaluation

0.25 g of the active ingredient complex for alleviating skin irritation prepared in the above Examples and Comparative Examples was completely dissolved in 10 g of distilled water and then incubated at 4°C, 25°C, 50°C, cycle (-18°C -> 25°C -> 40°C -> 25°C). ℃ -> -18 ℃ (maintained for 24 hours at each temperature, 1 hour required when changing temperature conditions) was stored for 4 weeks to observe whether precipitation occurred, and the results evaluated based on the following evaluation criteria are listed in Table 3 below.

1A: Precipitation occurs after 1 week of storage

2A: Precipitation occurs after 2 weeks of storage

3A: Precipitation occurs after 3 weeks of storage

4A: Precipitation occurs after 4 weeks of storage

-: No precipitation occurs

4℃ 25℃ 50℃ cycle Example 1 - - - - Example 2 - - - - Example 3 - - - - Comparative Example 1 2A 3A - 2A Comparative example 2 1A 2A 4A 1A Comparative example 3 2A 2A 4A 1A

Referring to Table 3, it can be seen that all of the composites of the examples prepared from the production method according to the present invention have excellent stability. Specifically, the composite prepared in the examples had excellent solubility in distilled water, so no precipitation occurred at all even when stored for 4 weeks under various temperature conditions. On the other hand, it can be seen that in the composite of the comparative example, precipitation occurred even under high temperature (50°C) conditions, and the stability of the product was significantly reduced.

Evaluation 2. Measurement of anti-inflammatory efficacy

2-1. NO and PGE ₂ production inhibition effect

To measure anti-inflammatory efficacy, mouse macrophages (Raw264.7) were treated with LPS (lipopolysaccharide) to induce an inflammatory response, and then the complex prepared in Example 1 was treated to produce inflammatory mediator NO (nitric oxide) and The efficacy of inhibiting the production of inflammatory cytokine PGE ₂ (prostaglandin E ₂ ) was analyzed. Specifically, macrophages (Raw 264.7 cells) were cultured under 5% CO ₂ conditions in medium supplemented with 10% serum. They were grown at a concentration of ^2Х105 in a 96-well plate culture medium, stimulated with LPS (1 ug/ml), treated with 300㎍/ml (=ppm) of the complex of Example 1, stored at 37°C for 1 hour, and then incubated with NO. and PGE- ₂ concentration were measured and the inhibition rate was calculated using Equation 1 below, and the results are shown in Table 4 below. Here, the control group refers to cells that were not treated with LPS.

[Equation 1]

Inhibition rate (%) = (sample group/control group)

2-2. IL-8 production inhibition effect

To measure anti-inflammatory efficacy, human HaCaT keratinocytes were treated with RA (Retinoic acid) to induce an inflammatory response, and then treated with the complex prepared in Example 1 to induce the inflammatory cytokine, Interleukin-8. 8, IL-8) production inhibition efficacy was measured. Specifically, ⁴ 5Х10 human HaCaT keratinocytes isolated from human epidermal tissue were placed in each well of a 24-well plate and cultured in a 5% CO ₂ incubator at 37°C for 24 hours. After 24 hours, the cells were washed twice with PBS, replaced with serum-free keratinocyte basement media (KBM), stimulated with 100 μM RA (Retinoic acid), and then incubated with the complex of Example 1 at 500 μg/ml (=ppm). ) After treatment and storage at 37°C for 1 hour, the IL-8 concentration was measured and the inhibition rate was calculated using Equation 1 above and shown in Table 4 below. Here, the control group refers to cells that were not treated with RA.

NO PGE ₂ IL-8 Inhibition rate (%) 98 70 99

As shown in Table 4 above, it can be seen that the complex according to the present invention can very well inhibit the expression of NO, PGE ₂ , and IL-8, which are involved in the expression of various inflammatory mediators.

Evaluation 3. Moisturizing efficacy measurement

Twenty women aged 19 to 26 were divided into two groups of 10 people each, one group was a placebo group and received the cosmetic composition of Comparative Example 4, and the other group was the composition of Example 4. was applied to the skin twice a day for 8 days. The skin moisture content was measured before application, 2 days after application, 4 days after application, 6 days after application, and 8 days after application, and the average value was calculated and shown in Table 5 below. The measuring device used was a moisture content meter (corneometer CM820, Courage + Khazaka, Cologne, Germany), which measures the moisturizing power by measuring the electrical capacitance of the skin according to the moisture content of the skin.

Before application 2 days later 4 days later 6 days later 8 days later Example 4 10 42 65 80 85 Comparative Example 4
(placebo) 10 15 18 30 38

Evaluation 4. Evaluation of skin irritation relief efficacy

The cosmetic composition of Example 4 was applied frequently to a man in his 30s who suffered from skin troubles, and changes were observed with the naked eye after one day of use. The results are shown in FIG. 1. As shown in Figure 1, it can be seen that the cosmetic composition containing the active ingredient complex for alleviating skin irritation according to the present invention has immediate effect in improving skin troubles and redness.

In summary, the method for producing an active ingredient complex for alleviating skin irritation according to the present invention can provide an active ingredient complex for alleviating skin irritation that contains a high concentration of the active ingredient in an aqueous solution and has high stability without phase separation such as precipitation. . In addition, the active ingredient complex for relieving skin irritation according to the present invention has excellent anti-inflammatory and moisturizing effects, has immediate effect in improving skin troubles and redness, and has excellent stability to the human body, making it useful in the prevention and treatment of various inflammatory skin diseases. It is expected that it can be used.

As described above, the present invention has been described with specific details and limited embodiments, but these are provided only to facilitate a more general understanding of the present invention, and the present invention is not limited to the above embodiments, and the field to which the present invention pertains is not limited to the above embodiments. Those skilled in the art can make various modifications and variations from this description.

Accordingly, the spirit of the present invention should not be limited to the described embodiments, and the scope of the patent claims described later as well as all things that are equivalent or equivalent to the scope of this patent claim shall fall within the scope of the spirit of the present invention. .

Claims (10)

Preparing a first complex aqueous solution by complexing betaine and madecassoside in an aqueous solution;
Preparing a second complex aqueous solution by adding and solubilizing allantoin to the first complex aqueous solution; and
A method for producing an active ingredient complex for alleviating skin irritation, comprising the step of dissolving an aliphatic polyhydric alcohol and an alicyclic polyhydric alcohol in the aqueous solution of the second complex. According to clause 1,
A method for producing an active ingredient complex for alleviating skin irritation, wherein the aliphatic polyhydric alcohol and the alicyclic polyhydric alcohol are moisturizing active ingredients. According to clause 1,
A method for producing an active ingredient complex for alleviating skin irritation, further comprising adding mucous polysaccharide extracted from seaweed to the second complex aqueous solution. A first complex aqueous solution in which betaine and madecassoside are complexed with each other;
An aqueous solution of the second complex in which allantoin is solubilized in the hydrophobic core of the first complex; and
An active ingredient complex for relieving skin irritation, comprising an aliphatic polyhydric alcohol and an alicyclic polyhydric alcohol. According to clause 4,
An active ingredient complex for alleviating skin irritation, further comprising a mucous polysaccharide extracted from seaweed. According to clause 4,
An active ingredient complex for alleviating skin irritation, in which the betaine and madecassoside are electrostatically complexed. According to clause 4,
An active ingredient complex for alleviating skin irritation, wherein madecassoside is included in an amount of 1 to 20 parts by weight based on 100 parts by weight of betaine. According to clause 4,
An active ingredient complex for alleviating skin irritation, wherein allantoin is included in an amount of 1 to 30 parts by weight based on 100 parts by weight of betaine. According to clause 4,
An active ingredient complex for alleviating skin irritation, wherein the total weight of aliphatic polyhydric alcohol and alicyclic polyhydric alcohol is 50 to 200 parts by weight based on 100 parts by weight of betaine. A cosmetic composition for alleviating skin irritation, comprising the active ingredient complex for alleviating skin irritation according to any one of claims 4 to 9.