KR102660996B1 - Composite material comprising ionic conductive gel and use thereof - Google Patents

Abstract

A composite material comprising an ion conductive gel and an insulating elastomer layer surrounding at least a portion of the ion conductive gel, a method of manufacturing the composite material, a fabric woven using the composite material, and at least one of the composite material and the fabric. Provides a patch that includes

Description

Composite material comprising ionic conductive gel and use thereof}

It relates to new composite materials and their uses.

Existing wound treatment materials are used to protect wounds, prevent external contamination, absorb exudate, and prevent bleeding or loss of body fluids. A representative example of a wet wound treatment material is a hydrogel material. Hydrogel refers to a state in which a large amount of moisture is filled within the polymer lattice to maintain a three-dimensional network structure. It has the property of absorbing moisture and swelling due to hydrophilic functional groups and capillary/osmotic pressure phenomena, so it can be used in various forms such as sheets and fluid gels. It is being used. In addition, the use of wet wound treatment materials is expanding due to its cooling effect on skin wounds, ease of application and removal, and suitability for treating serious wounds such as burns.

However, wet wound treatment materials not only require frequent replacement as moisture evaporates over time after application to the wound area, but in addition to providing a moist environment, they do not provide functionality to the cells themselves to promote wound healing. low. Therefore, there is a need to develop new types of wound treatment materials.

Meanwhile, it is known that human skin tissue basically has a potential of about 20-50 mV. This is an effect of the sodium/potassium pump that operates based on ATP in the epidermal layer of the skin. When a wound occurs, it induces a change in the maintained potential, which causes an electric potential to act in the direction of the wound, promoting cell movement and healing the wound. This is known as the skin battery effect. In this phenomenon, when electrical stimulation is applied from the outside, the ATP reaction can be promoted and cell differentiation can actively occur, thereby effectively treating the wound.

KR 10-1610268 B1

A composite material comprising an ion conductive gel and an insulating elastomer layer surrounding at least a portion of the ion conductive gel is provided.

A method for manufacturing the composite material is provided.

A fabric woven using the composite material is provided.

A patch comprising any one or more of the composite material and the fabric is provided.

One aspect includes an ion conductive gel comprising a matrix polymer, an electrolyte, and a solvent impregnated within the matrix polymer to maintain a gel state; and an insulating elastomer layer surrounding at least a portion of the ion conductive gel.

The composite material may further include a coating layer formed on the surface of the insulating elastomer layer.

The coating layer is made of (heptadecafluoro-1,1,2,2-tetrahydrodecyl)trichlorosilane (HDFS), polytetrafluoroethylene (PTFE), fluorinated ethylenepropyl copolymer (FEP), and perfluoroalkoxy ( It may include one or more types selected from the group consisting of PFA).

The matrix polymers include polyacrylamide, polyvinyl alcohol, polyvinylpyrrolidone, polypyrrole, polyvinyl chloride (PVC), poly(alkylacrylate), poly(ethyl acrylate), poly(ethylene terephthalate), and polymethyl Methacrylate (PMMA), polyaniline, polyvinylacetate, poly(ethylvinylacetate), poly(ethyl-co-vinyl acetate), polyvinylbutyrate, polyacrylate, polyacrylic acid ester, polymethacrylic acid ester, polymethacrylate Crylamide, polyacrylonitrile (PAN), polycaprolactone (PCL), polyvinylidene fluoride (PVDF), poly(2-vinylpyridine), polyvinylmethyl ether, polyvinyl butyral, polybenzimidazole, Polyetheretherketone, styrene/acrylic acid ester, vinyl acetate/acrylic acid ester, ethylene/vinyl acetate copolymer, polybutadiene, polyisoprene, polystyrene, polyethylene, polyethyleneimine, polyether, polyester, polycarbonate, polyamine, Polyurethane, polypropylene, polyamide, polyimide, polythiophene, polyacetylene, polyetherimide, polysulfone, polyethersulfone, polymethylstyrene, polychlorostyrene, polystyrene sulfonate, polystyrenesulfonyl fluoride, melamine- Formaldehyde resin, nylon, epoxy resin, polylactide, polyethylene oxide (PEO), polydimethylsiloxane, poly(styrene-co-acrylonitrile), poly(styrene-co-butadiene), poly(styrene-co-di) It may be one or more selected from the group consisting of vinyl benzene), poly(dimethylsiloxane-co-polyethylene oxide), poly(lactic acid-co-glycolic acid), silicone resin, and cellulose.

The electrolyte is LiCl, LiBr, LiI, LiClO ₄ , LiBF ₄ , LiB ₁₀ Cl ₁₀ , LiPF ₆ , LiCF ₃ SO ₃ , LiCF ₃ CO ₂ , LiAsF ₆ , LiSbF ₆ , LiAlCl ₄ , CH ₃ SO ₃ Li, CF ₃ SO ₃ Li, LiSCN, LiC(CF ₃ SO ₂ ) ₃ , (CF ₃ SO ₂ ) ₂ NLi, (FSO ₂ ) ₂ NLi, lithium chloroborane, lithium lower aliphatic carboxylate, lithium 4-phenyl borate, lithium imide , KCl, and NaCl ₂ It may be one or more selected from the group consisting of.

The solvent may be an organic solvent or water.

The organic solvent is ethylene glycol, N-methyl-2-pyrrolidone, N,N-dimethylformamide, N,N-dimethylacetamide, dimethyl sulfoxide, hexamethylenephosphotriamide, N-vinylpyrrolidone, N-vinylformamide, N-vinyl-acetamide, cresol, phenol, xylenol, diethylene glycol, triethylene glycol, propylene glycol, dipropylene glycol, 1,3-butylene glycol, 1,4-butylene Glycol, glycerin, diglycerin, D-glucose, D-glucitol, isoprene glycol, butanediol, 1,5-pentanediol, 1,6-hexanediol, 1,9-nonanediol, neopentyl glycol, ethylene carbonate, Propylene carbonate, dioxane, diethyl ether, dialkyl ether, propylene glycol dialkyl ether, polyethylene glycol dialkyl ether, polypropylene glycol dialkyl ether, 3-methyl-2-oxazolidinone, acetonitrile, glutarodinitrile. , methoxyacetonitrile, propionitrile, and benzonitrile.

The gel may be an organogel or hydrogel.

The insulating elastomer may be a silicone elastomer.

The insulating elastomer may be one or more selected from the group consisting of silicone rubber, polydimethylsiloxane (PDMS), polyvinylidene fluoride (PVDF), and polytetrafluoroethylene (PTFE).

The composite material may have a fibrous, plate-like, or granular structure.

The composite material may be a triboelectric power generation device.

Another aspect provides a method of manufacturing a composite material according to one aspect above.

The method includes preparing an ion-conductive gel precursor solution containing a matrix polymer monomer, a cross-linking agent, an electrolyte, and a solvent; Injecting the ion conductive gel precursor solution into the insulating elastomer layer; and polymerizing monomers of the matrix polymer.

The method may further include forming a coating layer on the surface of the insulating elastomer layer.

The polymerization may be polymerization by ultraviolet irradiation.

Another aspect provides a fabric woven using the composite material according to the above aspect.

Another aspect provides a patch comprising at least one of the composite material according to the above aspect and the fabric according to the above aspect.

The patch may be for skin regeneration, wound healing, or wrinkle improvement.

The composite material according to one aspect has biocompatibility, elasticity, and flexibility, and can generate triboelectricity, so it is a new material with excellent physical and electrical properties.

According to a method for manufacturing a composite material according to another aspect, a composite material having excellent physical and electrical properties can be manufactured.

Fabrics according to different aspects can be applied to various product groups in wearable form.

Patches according to different aspects can generate triboelectricity, so they can be applied for various purposes such as skin regeneration, wound healing, and wrinkle improvement.

Figure 1 is a diagram conceptually showing the configuration of a composite material 100 according to an embodiment.
Figure 2 is a conceptual diagram of the operating principle of a triboelectric power generation device.
Figure 3 is a flow chart sequentially showing a method for manufacturing a composite material according to an embodiment.
Figure 4 is an illustration of a composite material with a fibrous structure (right) and a fabric woven using the composite material (left) according to an embodiment.
Figure 5 is an exemplary diagram showing a patch according to an embodiment.
Figure 6 shows the elasticity and elastic modulus of the fibrous composite material.
Figure 7 shows the voltage generated in the fabric due to finger movement.
Figure 8 shows the experimental equipment and circuit diagram for quantitatively confirming the power generation amount of the fabric.
Figure 9 shows the generated voltage according to the movement frequency (Hz) and separation distance (d) of the aluminum plate.
Figure 10 shows the generated voltage according to the length (L) of the fiber strands from the fabric.
Figure 11 shows the results of evaluating the power generation durability of fabric.
Figure 12 shows the results confirming the effect of promoting cell movement through the frictional power of the fabric.
Figure 13 shows the results of confirming the cell proliferation effect through the friction power of the fabric.
Figure 14 shows the results showing the effect of promoting growth factor secretion through the friction power of the fabric.

Hereinafter, preferred embodiments of the present invention will be described in detail with reference to the accompanying drawings. However, the embodiments of the present invention concept may be modified into various other forms, and the scope of the present invention concept should not be construed as being limited to the embodiments described in detail below. It is preferable that the embodiments of the present invention be interpreted as being provided to more completely explain the present invention to those skilled in the art. Identical symbols refer to identical elements throughout. Furthermore, various elements and areas in the drawings are schematically drawn. Accordingly, the inventive concept is not limited by the relative sizes or spacing depicted in the accompanying drawings.

Terms such as first, second, etc. may be used to describe various components, but the components are not limited by the terms. The above terms are used only for the purpose of distinguishing one component from another. For example, a first component may be named a second component, and conversely, a second component may be named a first component without departing from the scope of the present invention concept.

The terms used in this application are only used to describe specific embodiments and are not intended to limit the inventive concept. Singular expressions include plural expressions unless the context clearly dictates otherwise. In this application, expressions such as “comprises” or “has” are intended to indicate the presence of features, numbers, steps, operations, components, parts, or combinations thereof described in the specification, but are not intended to indicate the presence of one or more other features or It should be understood that this does not exclude in advance the possibility of the presence or addition of numbers, operations, components, parts, or combinations thereof.

Unless otherwise defined, all terms used herein, including technical terms and scientific terms, have the same meaning as commonly understood by those skilled in the art in the technical field to which the concept of the present invention pertains. Additionally, commonly used terms, as defined in dictionaries, should be interpreted to have meanings consistent with what they mean in the context of the relevant technology, and should not be used in an overly formal sense unless explicitly defined herein. It will be understood that this is not to be interpreted.

In cases where an embodiment can be implemented differently, a specific process sequence may be performed differently from the described sequence. For example, two processes described in succession may be performed substantially at the same time, or may be performed in an order opposite to the order in which they are described.

In the accompanying drawings, variations of the depicted shape may be expected, for example, depending on manufacturing techniques and/or tolerances. Accordingly, embodiments of the present invention should not be construed as limited to the specific shape of the area shown in this specification, but should include, for example, changes in shape that occur during the manufacturing process. As used herein, any term “and/or” includes each and every combination of one or more of the mentioned elements.

<Composite materials>

One embodiment provides a composite material with biocompatibility, stretchability, and flexibility.

The composite material may include an ion conductive gel and an insulating elastomer layer surrounding at least a portion of the ion conductive gel.

The ion conductive gel may include a matrix polymer, an electrolyte, and a solvent impregnated in the matrix polymer to maintain the gel state.

Figure 1 is a diagram conceptually showing the configuration of a composite material 100 according to an embodiment.

Referring to Figure 1, the composite material 100 is an ion conductive gel 110 including a matrix polymer 111, an electrolyte 112, and a solvent 113 impregnated into the matrix polymer to maintain the gel state. ; And it may include an insulating elastomer layer 120 surrounding at least a portion of the ion conductive gel 110.

In addition, the composite material 100 may optionally further include a coating layer 130 formed on the surface of the insulating elastomer layer 120. The coating layer 130 may be formed on the surface of the insulating elastomer layer 120 to provide functionality to the insulating elastomer. In some embodiments, the coating layer 130 may be intended to have the property of acquiring more electrons on the surface of the insulating elastomer layer. In some embodiments, the coating layer 130 may be formed to fluorine the surface of the insulating elastomer layer 120. In some embodiments, the coating layer 130 is made of (heptadecafluoro-1,1,2,2-tetrahydrodecyl)trichlorosilane (HDFS). , it may include one or more selected from the group consisting of polytetrafluorethylene (PTFE), fluorinated ethylenepropylene copolymer (FEP), and perfluoroalkoxy (PFA). In one specific embodiment, the coating layer 130 may include HDFS.

The matrix polymer 111 may be arranged randomly or with certain regularity. In some embodiments, the matrix polymer 111 may be crosslinked. That is, two or more chains of the matrix polymer 111 can be crosslinked by having covalent bonds. In some embodiments, the covalent bond may be a direct bond between two or more chains, or a branched portion of one chain may be bonded to another chain. In some embodiments, the covalent bond may be a covalent bond linked by the addition of a separate cross-linking agent.

The matrix polymer 111 is, for example, polyacrylamide, polyvinyl alcohol, polyvinylpyrrolidone, polypyrrole, polyvinyl chloride (PVC), poly(alkylacrylate), poly(ethyl acrylate), poly (ethylene terephthalate), polymethyl methacrylate (PMMA), polyaniline, polyvinylacetate, poly(ethylvinylacetate), poly(ethyl-co-vinyl acetate), polyvinylbutyrate, polyacrylate, polyacrylic acid ester, Polymethacrylic acid ester, polymethacrylamide, polyacrylonitrile (PAN), polycaprolactone (PCL), polyvinylidene fluoride (PVDF), poly(2-vinylpyridine), polyvinylmethyl ether, polyvinyl Butyral, polybenzimidazole, polyetheretherketone, styrene/acrylic acid ester, vinyl acetate/acrylic acid ester, ethylene/vinyl acetate copolymer, polybutadiene, polyisoprene, polystyrene, polyethylene, polyethyleneimine, polyether, Polyester, polycarbonate, polyamine, polyurethane, polypropylene, polyamide, polyimide, polythiophene, polyacetylene, polyetherimide, polysulfone, polyethersulfone, polymethylstyrene, polychlorostyrene, polystyrene sulfonate, Polystyrenesulfonyl fluoride, melamine-formaldehyde resin, nylon, epoxy resin, polylactide, polyethylene oxide (PEO), polydimethylsiloxane, poly(styrene-co-acrylonitrile), poly(styrene-co-butadiene) , poly(styrene-co-divinyl benzene), poly(dimethylsiloxane-co-polyethylene oxide), poly(lactic acid-co-glycolic acid), silicone resin, and cellulose. Not limited. In one specific embodiment, the matrix polymer 111 may be polyacrylamide.

The matrix polymer 111 may be biocompatible and stable.

The electrolyte 112 may refer to a material that dissociates into ions in a solvent. Specifically, the electrolyte 112 may refer to a material that dissociates into positive and negative ions. The electrolyte 112 may be dispersed between the matrix polymers 111 or in the solvent 113. The electrolyte 112 may be distributed within the space formed between the molecules of the matrix polymers 111 and/or may be distributed on the surface of the molecules of the matrix polymers 111. The electrolyte 112 may be a material containing lithium ions, a material containing potassium ions, or a material containing sodium ions. The electrolyte 112 is, for example, LiCl, LiBr, LiI, LiClO ₄ , LiBF ₄ , LiB ₁₀ Cl ₁₀ , LiPF ₆ , LiCF ₃ SO ₃ , LiCF ₃ CO ₂ , LiAsF ₆ , LiSbF ₆ , LiAlCl ₄ , CH ₃ SO ₃ Li, CF ₃ SO ₃ Li, LiSCN, LiC(CF ₃ SO ₂ ) ₃ , (CF ₃ SO ₂ ) ₂ NLi, (FSO ₂ ) ₂ NLi, chloroborane lithium, lower aliphatic lithium carboxylate, 4 -Phenyl borate may be one or more selected from the group consisting of lithium borate, lithium imide, KCl, and NaCl ₂ , but is not limited thereto. In one specific embodiment, the electrolyte 112 may be a material containing lithium ions. In one specific embodiment, the electrolyte 112 may be LiCl.

The solvent 113 may be an organic solvent or water. The organic solvent may be an organic solvent whose vapor pressure is significantly lower than that of water. For example, the vapor pressure of the organic solvent may be about 0.01% to about 5% of the vapor pressure of water at 20°C. If the vapor pressure of the organic solvent is too low, the ability to impart elasticity and flexibility to the produced organic gel may be insufficient. If the vapor pressure of the organic solvent is too high, it is easily vaporized and the organic gel may harden in a short time. In some embodiments, the organic solvent may be a polar organic solvent. In some embodiments, the organic solvent may be a solvent having a boiling point of about 150°C to 400°C. In some embodiments, the organic solvent is, for example, ethylene glycol, N-methyl-2-pyrrolidone, N,N-dimethylformamide, N,N-dimethylacetamide, dimethyl sulfoxide, hexamethylenephosphide. Pottriamide, N-vinylpyrrolidone, N-vinylformamide, N-vinyl-acetamide, cresol, phenol, xylenol, diethylene glycol, triethylene glycol, propylene glycol, dipropylene glycol, 1,3- Butylene glycol, 1,4-butylene glycol, glycerin, diglycerin, D-glucose, D-glucitol, isoprene glycol, butanediol, 1,5-pentanediol, 1,6-hexanediol, 1,9- Nonanediol, neopentyl glycol, ethylene carbonate, propylene carbonate, dioxane, diethyl ether, dialkyl ether, propylene glycol dialkyl ether, polyethylene glycol dialkyl ether, polypropylene glycol dialkyl ether, 3-methyl-2-oxa It may be one or more selected from the group consisting of zolidinone, acetonitrile, glutarodinitrile, methoxyacetonitrile, propionitrile, and benzonitrile, but is not limited thereto. In a specific example, the organic solvent may be ethylene glycol.

The ion conductive gel 110 may be an organogel or hydrogel. When the solvent 113 is an organic solvent, the ion conductive gel 110 formed is an organic gel. When the solvent 113 is water, the ion conductive gel 110 formed is a hydrogel.

Since the electrolyte 112 inside the ion conductive gel 110 is dissociated into positive and negative ions, electrical conduction can be achieved through the movement of ions.

The insulating elastomer layer 120 may be an insulator (dielectric). The insulating elastomer layer 120 can prevent the solvent 113 of the ion conductive gel 110 from evaporating. The insulating elastomer layer 120 can maintain electrical potential for a long period of time by preventing ions present in the ion conductive gel 110 from leaking out.

The shape of the insulating elastomer layer 120 is not limited to a specific shape, and various shapes can be selected depending on the purpose. The insulating elastomer layer 120 may cover at least a portion of the ion conductive gel 110. The insulating elastomer layer 120 may cover the entire surface of the ion conductive gel 110. In some embodiments, the insulating elastomer layer 120 exists in the form of a tube and may surround at least a portion of the ion conductive gel 110. In some embodiments, the insulating elastomer layer 120 exists in a hollow form and may cover the entire surface of the ion conductive gel 110.

The insulating elastomer may be a silicone elastomer. The insulating elastomer may be, for example, at least one selected from the group consisting of silicone rubber, polydimethylsiloxane (PDMS), polyvinylidene fluoride (PVDF), and polytetrafluoroethylene (PTFE). may, but is not limited to this.

The insulating elastomer layer 120 may have elasticity and flexibility.

The structure of the composite material 100 is not limited to a specific structure, and can be manufactured into various structures depending on the intended use. The composite material 100 may have a fibrous, plate-like, or granular structure. In some embodiments, when the composite material 100 has a fibrous structure, a tube-shaped insulating elastomer layer 120 may surround at least a portion of the ion conductive gel 110. In some embodiments, the composite material 100 may have a microfiber or nanofiber structure. In some embodiments, the composite material 100 may have a microfiber structure in which a tubular insulating elastomer layer 120 with a micro-sized diameter surrounds at least a portion of the ion conductive gel 110. In some embodiments, the composite material 100 may have a nanofiber structure in which a tubular insulating elastomer layer 120 with a nano-sized diameter surrounds at least a portion of the ion conductive gel 110. In some embodiments, when the composite material 100 has a plate-shaped structure, the plate-shaped insulating elastomer layer 120 may surround at least part or all of the ion conductive gel 110. In some embodiments, when the composite material 100 has a granular structure, the hollow insulating elastomer layer 120 may surround the entire ion conductive gel 110. That is, the entire surface of the ion conductive gel 110 may be covered with the insulating elastomer layer 120.

The composite material 100 may be a triboelectric power generation device. Therefore, the composite material may be a triboelectric generator, and specifically, it may be a triboelectric microgenerator or a triboelectric nanogenerator (TENG).

Figure 2 is a conceptual diagram of the operating principle of a triboelectric power generation device.

When the composite material 100 comes in contact with human skin, which is positively charged, it can generate triboelectricity by obtaining electrons from the human skin. Specifically, when the composite material 100 and human skin come into contact, electrons are transferred from the skin to the composite material 100 through the interface. Electrons that move to the composite material 100 cannot move and accumulate because the insulating elastomer layer 120 of the composite material 100 is an insulator. When the composite material 100 moves away from the skin, electrons accumulated in the insulating elastomer layer 120 attract positive ions in the ion conductive gel 110 and repel negative ions, which are the opposite charge, by electrostatic induction for electrical stability. . As the distance between the composite material 100 and the skin increases, more ions can be induced because the skin is less affected by the positive charge. Additionally, the faster the separation occurs, the correspondingly faster the ions can move. At this time, a flow of ions occurs, and negative ions accumulated on one side form an electric field. Therefore, an electric field can be generated due to mechanical friction without external energy such as a battery or power source.

The composite material 100 may have elasticity and flexibility. The composite material 100 is about 1.5 times to about 10 times its own length, for example, about 1.5 times to about 5 times, about 1.5 times to about 3 times, about 2 times to about 10 times, about 2 times. It can be increased by about 5 times, about 2 times, or about 3 times. Therefore, the composite material 100 may have sufficient elasticity and flexibility to be applied in a wearable form. The composite material 100 can significantly reduce the feeling of foreign body when worn on the body compared to other materials such as metal.

<Method of manufacturing composite materials>

Hereinafter, a method of manufacturing the composite material 100 as described above will be described.

A method of manufacturing a composite material according to one embodiment includes preparing an ion-conducting gel precursor solution containing a monomer of a matrix polymer, a cross-linking agent, an electrolyte, and a solvent; Injecting the ion conductive gel precursor solution into the insulating elastomer layer; and polymerizing monomers of the matrix polymer.

Figure 3 is a flow chart sequentially showing a method for manufacturing a composite material according to an embodiment.

Referring to Figure 3, an ion conductive gel precursor solution containing a matrix polymer monomer, a cross-linking agent, an electrolyte, and a solvent is prepared (S110). Here, details regarding the matrix polymer, electrolyte, and solvent are as described above.

The ion conductive gel precursor solution can be prepared by mixing a matrix polymer monomer, a crosslinking agent, an electrolyte, and a solvent. The ion conductive gel precursor solution may further include an initiator. The ion conductive gel precursor solution may be prepared by dissolving the monomer and electrolyte of the matrix polymer in a solvent and then adding a crosslinking agent and an initiator, but the order is not particularly limited. The ion conductive gel precursor solution may be in the form of a fluid sol.

The matrix polymer is as described above, and the monomers for synthesizing them are well known to those skilled in the art to which the present invention pertains, so specific examples are omitted. The content of monomer in the ion conductive gel precursor solution may be selected at an appropriate amount to ensure sufficient volume and/or size of the matrix polymer.

The cross-linker may be an agent for causing a cross-linking reaction in the polymerization of the monomers.

The crosslinking agent may be one or more of an isocyanate-based crosslinking agent, a peroxide-based crosslinking agent, an epoxy-based crosslinking agent, and an amine-based crosslinking agent.

Compounds related to isocyanate-based crosslinking agents include, for example, isocyanate monomers such as tolylene diisocyanate, chlorphenylene diisocyanate, tetramethylene diisocyanate, xylylene diisocyanate, diphenylmethane diisocyanate, and hydrogenated diphenylmethane diisocyanate, and Isocyanate compounds, isocyanurate compounds, and biuret-type compounds obtained by adding these isocyanate monomers such as trimethylolpropane, and furthermore, urethane prepolymers obtained by addition reaction such as polyether polyol, polyester polyol, acrylic polyol, polybutadiene polyol, and polyisoprene polyol. type isocyanate, etc. are mentioned. In particular, it is a polyisocyanate compound, and may be one type selected from the group consisting of hexamethylene diisocyanate, hydrogenated xylylene diisocyanate, and isophorone diisocyanate, or a polyisocyanate compound derived therefrom.

The peroxide-based crosslinking agent is, for example, di(2-ethylhexyl)peroxydicarbonate, di(4-t-butylcyclohexyl)peroxydicarbonate, di-sec-butylperoxydicarbonate, and t-butylperoxyneode. Decanoate, t-hexylperoxypivalate, t-butylperoxypivalate, dilauroyl peroxide, di-n-octanoyl peroxide, 1,1,3,3-tetramethylbutylperoxy-2- It may be ethylhexanoate, di(4-methylbenzoyl)peroxide, dibenzoyl peroxide, t-butylperoxyisobutyrate, 1,1-di(t-hexylperoxy)cyclohexane, etc.

Examples of the epoxy-based crosslinking agent include N,N,N',N'-tetraglycidyl-m-xylenediamine, diglycidylaniline, 1,3-bis(N,N-glycidylaminomethyl ) Cyclohexane, 1,6-hexanediol diglycidyl ether, neopentyl glycol diglycidyl ether, ethylene glycol diglycidyl ether, propylene glycol diglycidyl ether, polyethylene glycol diglycidyl ether, poly Propylene glycol diglycidyl ether, sorbitol polyglycidyl ether, glycerol polyglycidyl ether, pentaerythritol polyglycidyl ether, polyglycerol polyglycidyl ether, sorbitan polyglycidyl ether, trimethylolpropane Polyglycidyl ether, adipic acid diglycidyl ester, o-phthalic acid diglycidyl ester, triglycidyl-tris(2-hydroxyethyl)isocyanurate, resorcinol diglycidyl ether, bisphenol- It may be S-diglycidyl ether, etc.

The amine-based crosslinking agent may be, for example, a compound having a plurality of amino groups such as ethylenediamine. Ethylenediamines specifically include ethylenediamine, 1,2-diaminopropane, 1,2-diamino-2-methylpropane, N-methylethylenediamine, N-ethylethylenediamine, N-isopropylethylenediamine, N-hexylethylenediamine, N-cyclohexylethylenediamine, N-octylethylenediamine, N-decylethylenediamine, N-dodecylethylenediamine, N,N-dimethylethylenediamine, N,N-diethylethylenediamine, N ,N'-diethylethylenediamine, N,N'-diisopropylethylenediamine, N,N,N'-trimethylethylenediamine, diethylenetriamine, N-isopropyldiethylenetriamine, N-(2- Aminoethyl)-1,3-propanediamine, triethylenetetramine, N,N'-bis(3-aminopropyl)ethylenediamine, N,N'-bis(2-aminoethyl)-1,3-propanediamine , tris(2-aminoethyl)amine, tetraethylenepentamine, pentaethylenehexamine, 2-(2-aminoethylamino)ethanol, N,N'-bis(hydroxyethyl)ethylenediamine, N-(hydroxy Examples include ethyl)diethylenetriamine, N-(hydroxyethyl)triethylenetetramine, piperazine, 1-(2-aminoethyl)piperazine, 4-(2-aminoethyl)morpholine, and polyethyleneimine. there is. Diamines and polyamines applicable in addition to ethylenediamines include, specifically, 1,3-diaminopropane, 1,4-diaminobutane, 1,3-diaminopentane, 1,5-diaminopentane, 2, 2-dimethyl-1,3-propanediamine, hexamethylenediamine, 2-methyl-1,5-diaminopropane, 1,7-diaminoheptane, 1,8-diaminoctane, 2,2,4-trimethyl -1,6-hexanediamine, 2,4,4-trimethyl-1,6-hexanediamine, 1,9-diaminononane, 1,10-diaminodecane, 1,12-diaminododecane, N -Methyl-1,3-propanediamine, N-ethyl-1,3-propanediamine, N-isopropyl-1,3-propanediamine, N,N-dimethyl-1,3-propanediamine, N,N' -Dimethyl-1,3-propanediamine, N,N'-diethyl-1,3-propanediamine, N,N'-diisopropyl-1,3-propanediamine, N,N,N'-trimethyl- 1,3-propanediamine, 2-butyl-2-ethyl-1,5-pentanediamine, N,N'-dimethyl-1,6-hexanediamine, 3,3'-diamino-N-methyldipropylamine , N-(3-aminopropyl)-1,3-propanediamine, spermidine, methylenebisacrylamide, bis(hexamethylene)triamine, N,N',N''-trimethylbis(hexamethylene)tri Amine, 4-aminomethyl-1,8-octanediamine, N,N'-bis(3-aminopropyl)-1,3-propanediamine, spermine, 4,4'-methylenebis(cyclohexylamine) , 1,2-diaminocyclohexane, 1,4-diaminocyclohexane, 1,3-cyclohexanebis(methylamine), 1,4-cyclohexanebis(methylamine), 1,2-bis(amino Ethoxy)ethane, 4,9-dioxa-1,12-dodecanediamine, 4,7,10-trioxa-1,13-tridecanediamine, 1,3-diaminohydroxypropane, 4,4 Examples include '-methylenedipiperidine, 4-(aminomethyl)piperidine, 3-(4-aminobutyl)piperidine, and polyallylamine, but are not limited to these.

In a specific example, the crosslinking agent may be methylenebisacrylamide.

The crosslinking agent may be used in an amount of about 0.005 parts by weight to about 1 part by weight, or about 0.01 parts by weight to about 0.5 parts by weight, based on 100 parts by weight of the monomer.

The initiator may be a photoinitiator. The initiator is, for example, lithium phenyl-2,4,6-trimethylbenzoylphosphinate, benzoyl peroxide, dibenzoyl peroxide, monochlorobenzoyl peroxide, dichlorobenzoyl peroxide, p-methylbenzoyl peroxide, Octane oil peroxide, decane oil peroxide, lauroyl peroxide, dilauryl peroxide, cyclohexane peroxide, methyl ethyl ketone peroxide, di- tert -butyl peroxide, dicumyl peroxide, tert -butyl hydroperoxide. , tert -amyl hydroperoxide, cumene hydroperoxide, dicyclohexyl peroxydicarbonate, 2,2'-azobisisobutyronitrile (AIBN), 2,2'-azobis(2-methylbutyronitrile) , azo-2-cyanovaleric acid, azobis-(2,4-dimethyl)-valeronitrile, tert -butyl perbenzoate, di- tert -butyl peroxyphthalate, potassium persulfate (potassium persulfate, PPS) , ammonium persulfate (APS), sodium persulfate (SPS), etc., but is not limited thereto. In a specific example, the initiator may be lithium phenyl-2,4,6-trimethylbenzoylphosphinate.

The initiator is used in an amount effective to initiate polymerization of the monomer, and the amount will vary depending, for example, on the type of initiator and the desired polymer molecular weight and degree of functionality. The initiator may be used in an amount of about 0.001 parts by weight to about 10 parts by weight, or about 0.01 parts by weight to about 1 part by weight, based on 100 parts by weight of the monomer.

The ion conductive gel precursor solution may further include an accelerator to promote the polymerization reaction of the monomers. The type of accelerator may be appropriately selected from those commonly used in this technical field. The accelerator is used in an amount effective to promote polymerization of the monomer, and the amount will vary depending, for example, on the type of accelerator and the desired polymer molecular weight and degree of functionality.

Next, the ion conductive gel precursor solution is injected into the insulating elastomer layer (S120). Here, details regarding the insulating elastomer layer are as described above.

The injection can be performed using any conventional method used in the art. In some embodiments, the injection may be performed using a needle. The term ‘injecting into the insulating elastomer layer’ may mean positioning the ion conductive gel precursor solution so that the insulating elastomer layer surrounds at least a portion of the ion conductive gel.

Next, the monomers of the matrix polymer are polymerized (S130).

For the polymerization, an appropriate method can be selected depending on the type of monomer. The polymerization may be polymerization by thermal curing or photo curing. In some examples, the polymerization may be polymerization by ultraviolet irradiation. The ultraviolet irradiation may be performed for a sufficient time for a crosslinking reaction to occur. In some embodiments, the ultraviolet irradiation is, for example, 1 minute to 10 minutes, 1 minute to 8 minutes, 1 minute to 6 minutes, 2 minutes to 10 minutes, 2 minutes to 8 minutes, 2 minutes to 6 minutes, It may be performed for 4 to 10 minutes, 4 to 8 minutes, or 4 to 6 minutes, but is not limited thereto.

The method may optionally further include forming a coating layer on the surface of the insulating elastomer layer. The step of forming the coating layer may be performed before or after step S120.

After forming the coating layer, a step of washing the insulating elastomer may be further included. The washing can be performed according to conventional methods in the art.

<Fabric>

One embodiment provides a fabric woven using the composite material.

Figure 4 is an illustration of a composite material with a fibrous structure (right) and a fabric woven using the composite material (left) according to an embodiment.

The fabric can be woven according to a conventional method in this technical field using a composite material 100 having a fibrous structure. The fabric may be woven in the form of plain weave, twill weave, satin weave, etc., but is not limited thereto.

The fabric may be biocompatible, stretchable, and flexible. Therefore, it can be applied in a variety of ways in a wearable form. When the wearable fabric is brought into contact with the body's skin, triboelectricity can be generated without an external energy source.

<Patch>

One embodiment provides a patch including any one or more of the composite material and a fabric woven using the composite material.

The patch includes a first part for attaching to a part of the body that moves a lot; a second part for attachment to a body part in need of skin regeneration, wound healing, or wrinkle improvement; And it may include a third part connecting the first part and the second part.

The first part may include a fabric woven using a composite material having a fibrous structure, but is not limited thereto.

The second part may include a composite material having a plate-like structure, but is not limited thereto.

The third part may include a composite material having a fibrous structure, but is not limited thereto.

The patch may be for skin regeneration, wound healing, or wrinkle improvement.

Figure 5 is an exemplary diagram showing a patch according to an embodiment.

“Skin regeneration” can refer to any action that replenishes a lost or damaged part of the skin or enhances the proliferation and migration of skin cells. As the skin regenerates, wrinkle improvement effects may appear.

“Wrinkle” refers to a condition in which the skin loses its elasticity and becomes loose, for example, the skin may be folded.

“Improvement” may mean any action that at least reduces the severity of a parameter associated with the alleviation or treatment of a condition, such as symptoms.

“Wrinkle improvement” can mean any action that lightens or reduces wrinkles on the face or body.

“Wound” is also called “wound” and refers to damage to a living body. The damage may be caused by external factors such as physical damage, radiation, stimulation by chemicals, proliferation of microorganisms, or internal factors such as stress, but is not limited to these. The wounds may include all types of wounds, such as incisional wounds, puncture wounds, abdominal wounds, acne wounds, fissures, oblique wounds, and school wounds.

“Wound improvement” can mean any action that lightens or reduces the severity of scars on the face or body.

“Wound healing” can refer to a series of biological reactions that repair wounds.

The cause of the skin regeneration, wrinkle improvement, wound improvement, or wound healing is not limited, but may be, for example, migration or proliferation of skin cells.

The patch may increase the expression of growth factors. The patch may increase the expression of any one or more of FGF, VEGF, and EGF. The patch can accelerate wound healing by promoting blood vessel regeneration by increasing the expression of any one or more of FGF, VEGF, and EGF.

The patch can prevent secondary complications through open wounds through rapid wound healing.

Since the patch can generate triboelectricity without an external energy source when attached to the skin, it can efficiently control the movement and proliferation of skin cells and promote skin regeneration.

The patch can significantly reduce physical side effects by using electrical stimulation treatment technology that utilizes the wound healing mechanism that occurs naturally in the body.

The patch is more stable than products using existing metal electrodes, and can utilize triboelectricity naturally occurring in the living body without an external energy source. Additionally, the patch is wearable on the human body because it contains a composite material with excellent biocompatibility, elasticity, and flexibility.

<Methods for skin regeneration, wound healing, or wrinkle improvement>

One embodiment provides a method for skin regeneration, wound healing, or wrinkle improvement comprising attaching or contacting the patch to an object.

“Subject” means any animal, including humans, in need of skin regeneration, wound healing, or wrinkle improvement.

<Manufacture Example 1: Manufacture of composite material>

(1) Preparation of materials

Acrylamide (AAm; Sigma, A8887) was used as a monomer for the organogel. N, N -methylenebisacrylamide (MBAAm; Sigma, M7279) was used as a crosslinking agent for the organogel. Ethylene glycol (EG; Dae-Jung, 4026-4404) was used as a solvent to form the organogel. LiCl (Sigma, L4408) was used as an ionic charge carrier. Lithium phenyl-2,4,6-trimethylbenzoylphosphinate (LAP; Sigma, 900889) was used as a photoinitiator.

A silicone tube (Axel, 1-8194-05) with an inner diameter of 500 μm and an outer diameter of 600 μm was used as a dielectric. (heptadecafluoro-1,1,2,2-tetrahydrodecyl)trichlorosilane ((heptadecafluoro-1,1,2,2-tetrahydrodecyl)trichlorosilane, HDFS; JSI Silicone Co., H5060.1) on the surface. It was used as a fluorinated agent.

(2) Preparation of ion conductive gel precursor solution

First, an ion conductive gel precursor solution was prepared by dissolving acrylamide and LiCl in ethylene glycol. The molar concentrations of acrylamide and LiCl were 3.5 M and 1.5 M, respectively. Based on 100 parts by weight of acrylamide, 0.124 parts by weight of N,N -methylenebisacrylamide and 0.012 parts by weight of lithium phenyl-2,4,6-trimethylbenzoylphosphinate were added.

(3) Production of composite material containing ion conductive gel

Surface etching of the pre-strained (150%) silicone tube was performed using an air plasma processing system (FEMTO SCIENCE, COVANCE-1MPR) at 200 W, 1 hour, and 15 standard cubic centimeters per minute (sccm). The silicone tube was immersed in a solution of HDFS and hexane mixed at a ratio of 1:500. Self-assembled monolayer formation occurred over a period of 20 min. Next, the silicone tube surface coated with HDFS was washed with hexane for 10 minutes. After injecting the prepared ion conductive gel precursor solution into the surface-coated silicone tube, 365 nm ultraviolet irradiation (CL-1000L, UVP) was performed for 5 minutes under inert conditions to crosslink. Finally, a fibrous composite material was obtained in which an ion-conducting organic gel was filled in a silicone tube surface-coated with HDFS.

<Manufacture Example 2: Manufacture of composite material>

A fibrous composite material in which the silicone tube was filled with an ion conductive organic gel was manufactured using the same method as Preparation Example 1, except that a silicone tube without a surface coating was used instead of a silicone tube surface coated with HDFS.

<Manufacture Example 3: Manufacture of woven fabric using fibrous composite material>

Fabric was manufactured by hand weaving the fibrous composite material prepared in Preparation Example 1.

<Experimental Example 1: Evaluation of mechanical properties of composite materials>

The mechanical properties of one strand of the fibrous composite material prepared in Preparation Example 1 were confirmed through a tensile test.

Figure 6 shows the elasticity and elastic modulus of the fibrous composite material.

As shown in Figure 6, the fibrous composite material stretched to 2.6 times its length and showed an elastic modulus of 2 MPa. In other words, the physical properties were similar to those of the silicone tube itself, regardless of the presence or absence of gel. Therefore, the fibrous composite material was confirmed to have sufficient flexibility and elasticity to be applied in a wearable form. The fibrous composite material can reduce foreign body sensation when used as a body attachment type due to its high flexibility and elasticity.

<Experimental Example 2: Evaluation of electrical properties of fabric woven using composite materials>

(1) Measurement of voltage generated by body movement

The fabric prepared in Preparation Example 3 was applied to the finger joint, and then the finger was moved to generate voltage by rubbing the fabric and the finger.

Figure 7 shows the voltage generated in the fabric due to finger movement.

As shown in Figure 7, the amount of power generation varied depending on the degree to which the finger was bent, and the amount of power generation increased as the finger was bent to a greater angle. This is because the faster the finger moves and the greater the angle, the faster the movement speed and the greater the separation between the skin and the fabric.

(2) Quantitative confirmation of the power generation amount of the fabric

Using a pushing tester, the level of frictional power generated differently depending on various external conditions such as movement frequency and force was confirmed.

Figure 8 shows the experimental equipment and circuit diagram for quantitatively confirming the power generation amount of the fabric.

Specifically, to confirm the power generation characteristics of the woven fibrous composite material, an experiment was conducted using a friction tester that can apply quantitative mechanical friction to the sample. This friction tester generates consistent movement speed, contact area, and clearance. In this experiment, an aluminum plate was used as a friction material, and aluminum plate has charging characteristics similar to skin. Power generation characteristics were evaluated by connecting an external resistance to the end of the woven fibrous composite material and measuring the voltage formed on the external resistance.

First, we attached an aluminum plate on top and repeated the process of pressing and releasing the top surface of the healing patch to check how long the generated friction electricity lasts. As a result, it was confirmed that the same intensity of power was maintained even after 6 hours.

Next, the generated voltage was measured according to the movement frequency and separation distance of the aluminum plate.

Figure 9 shows the generated voltage according to the movement frequency (Hz) and separation distance (d) of the aluminum plate.

As shown in Figure 9, it was confirmed that as the frequency of movement increased from 0.5 Hz to 2.0 Hz, the amount of power generation increased from 25 Vpp to 75 Vpp. In addition, it was confirmed that as the maximum separation distance between the fabric and the aluminum plate increased from 0.5 cm to 2 cm, the voltage increased from 33 Vpp to 73 Vpp. Therefore, it was confirmed that as the movement frequency and separation distance of the aluminum plate increased, the intensity of triboelectricity generated also increased.

It is advantageous to attach the fabric to the most active part of the body to ensure maximum power generation. At this time, the distance between the position of the fabric attached to the active area and the position of the fabric attached to the wound may become long. The distance between these can be easily connected by extending the length of the fiber strands from the fabric. The composite fiber strands are elastic and can minimize the foreign body sensation that a person may feel when wearing them. However, as the length of the composite fiber strands increases, there may be electrical loss due to increased resistance. To confirm this loss, the voltage developed along the length of the fiber strand was checked.

Figure 10 shows the generated voltage according to the length (L) of the fiber strands from the fabric.

As shown in Figure 10, it was confirmed that the power generation amount decreased slightly from 81 Vpp to 78 Vpp as the fiber strand lengthened from 0.1 m to 2.5 m. However, since the degree of reduction in power generation was not large, it was found that the distance between the fabric attached to the wound area and the fabric attached to the exercise area could be extended with fiber strands.

<Experimental Example 3: Evaluation of the power generation durability of fabric>

An experiment was conducted to evaluate the power generation durability of the fabric manufactured in Preparation Example 3.

Figure 11 shows the results of evaluating the power generation durability of fabric.

As shown in Figure 11, the generated voltage of the fabric was maintained at about 80 Vpp while being rubbed about 30,000 times. High voltage was generated consistently for about 5 days, and a decrease in power generation occurred on the 6th day. However, the slight change in power generation seen in the graph may be affected by the surrounding environment, such as temperature and humidity at the time of measurement. Therefore, it was confirmed that the fabric had excellent power generation durability.

<Experimental Example 4: Evaluation of fabric’s skin regeneration, wound healing, and wrinkle improvement abilities>

In order to confirm the degree of skin regeneration, wound healing, or wrinkle improvement using the friction power generated from the fabric manufactured in Preparation Example 3, the cell migration effect and degree of proliferation were confirmed.

Normal human dermal fibroblast (HDF) and DM (diabetes mellitus) fibroblasts extracted from diabetic patients were prepared. Electrodes were placed where the fibroblasts were located on both sides with a gap of 500 μm, and triboelectricity generated from the fabric was transmitted. As a control group, one that did not transmit triboelectricity to the cells was used.

Figure 12 shows the results confirming the effect of promoting cell movement through the frictional power of the fabric.

As shown in Figure 12, as a result of electrical stimulation at Vpp 10 V at 4 Hz for 6 hours, the degree of movement of cells receiving triboelectric stimulation increased by about 4 times compared to the control group in the case of normal fibroblasts, and DM fibers In the case of blast cells, it was confirmed that the increase was approximately two-fold compared to the control group. Through this, it was found that fabrics using composite materials can be applied to areas where wound healing is not active, such as diabetic ulcers.

Figure 13 shows the results of confirming the cell proliferation effect through the friction power of the fabric.

As shown in Figure 13, in the case of fibroblasts that received triboelectric stimulation generated from the fabric, it was confirmed that the degree of cell proliferation increased by about 1.5 to 2 times while being aligned in the direction of the electrical stimulation.

Next, growth factors released from fibroblasts were analyzed using enzyme-linked immunosorbent assay (ELISA). FGF (Fibroblast growth factor) and VEGF (Vascular Endothelial growth factor), which are closely related to vascular regeneration, which are important phenomena in wound healing, and EGF (Epidermal growth factor), which is related to re-epithelialization, were measured. FGF is known to be a growth factor that affects cell proliferation, differentiation, and survival, and in particular, FGF is known to induce VEGF expression in endothelial cells. VEGF is widely known as the most basic growth factor for the growth of vascular endothelial cells. It is known that EGF expressed in fibroblasts promotes re-epithelialization of the wound area by inducing proliferation of nearby endothelial cells and keratinocytes.

Figure 14 shows the results showing the effect of promoting growth factor secretion through the friction power of the fabric.

As shown in Figure 14, it was confirmed that both normal fibroblasts and diabetic fibroblasts showed high expression of FGF, VEGF, and EGF when receiving triboelectric stimulation of the fabric. Through this, it was found that triboelectric stimulation can accelerate wound healing by promoting blood vessel regeneration within the wound area.

Therefore, it was confirmed that the composite material can be applied to a variety of products such as skin regeneration, wound healing, and wrinkle improvement patches.

100: composite material
110: Ion conductive gel
111: Matrix polymer
112: electrolyte
113: Solvent
120: insulating elastomer layer
130: Coating layer

Claims (18)

An ion conductive gel comprising a matrix polymer, an electrolyte, and a solvent impregnated within the matrix polymer to maintain a gel state; and
A composite material comprising an insulating elastomer layer surrounding at least a portion of the ion conductive gel. The composite material according to claim 1, further comprising a coating layer formed on the surface of the insulating elastomer layer. The method of claim 2, wherein the coating layer is (heptadecafluoro-1,1,2,2-tetrahydrodecyl)trichlorosilane (HDFS), polytetrafluoroethylene (PTFE), fluorinated ethylenepropyl copolymer (FEP), And a composite material comprising at least one selected from the group consisting of perfluoroalkoxy (PFA). The method of claim 1, wherein the matrix polymer is polyacrylamide, polyvinyl alcohol, polyvinylpyrrolidone, polypyrrole, polyvinyl chloride (PVC), poly(alkylacrylate), poly(ethyl acrylate), and poly(ethylene terete). phthalate), polymethyl methacrylate (PMMA), polyaniline, polyvinylacetate, poly(ethylvinylacetate), poly(ethyl-co-vinyl acetate), polyvinylbutyrate, polyacrylate, polyacrylic acid ester, polymethacrylic Acid ester, polymethacrylamide, polyacrylonitrile (PAN), polycaprolactone (PCL), polyvinylidene fluoride (PVDF), poly(2-vinylpyridine), polyvinylmethyl ether, polyvinyl butyral, Polybenzimidazole, polyetheretherketone, styrene/acrylic acid ester, vinyl acetate/acrylic acid ester, ethylene/vinyl acetate copolymer, polybutadiene, polyisoprene, polystyrene, polyethylene, polyethyleneimine, polyether, polyester, Polycarbonate, polyamine, polyurethane, polypropylene, polyamide, polyimide, polythiophene, polyacetylene, polyetherimide, polysulfone, polyethersulfone, polymethylstyrene, polychlorostyrene, polystyrenesulfonate, polystyrenesulfonyl. Fluoride, melamine-formaldehyde resin, nylon, epoxy resin, polylactide, polyethylene oxide (PEO), polydimethylsiloxane, poly(styrene-co-acrylonitrile), poly(styrene-co-butadiene), poly( A composite material comprising at least one selected from the group consisting of styrene-co-divinyl benzene), poly(dimethylsiloxane-co-polyethylene oxide), poly(lactic acid-co-glycolic acid), silicone resin, and cellulose. The method of claim 1, wherein the electrolyte is LiCl, LiBr, LiI, LiClO ₄ , LiBF ₄ , LiB ₁₀ Cl ₁₀ , LiPF ₆ , LiCF ₃ SO ₃ , LiCF ₃ CO ₂ , LiAsF ₆ , LiSbF ₆ , LiAlCl ₄ , CH ₃ SO ₃ Li, CF ₃ SO ₃ Li, LiSCN, LiC(CF ₃ SO ₂ ) ₃ , (CF ₃ SO ₂ ) ₂ NLi, (FSO ₂ ) ₂ NLi, lithium chloroborane, lithium lower aliphatic carboxylate, 4-phenyl boric acid A composite material comprising at least one selected from the group consisting of lithium, lithium imide, KCl, and NaCl ₂ . The composite material according to claim 1, wherein the solvent is an organic solvent or water. The method of claim 6, wherein the organic solvent is ethylene glycol, N-methyl-2-pyrrolidone, N,N-dimethylformamide, N,N-dimethylacetamide, dimethyl sulfoxide, hexamethylenephosphotriamide, N- Vinylpyrrolidone, N-vinylformamide, N-vinyl-acetamide, cresol, phenol, xylenol, diethylene glycol, triethylene glycol, propylene glycol, dipropylene glycol, 1,3-butylene glycol, 1 , 4-butylene glycol, glycerin, diglycerin, D-glucose, D-glucitol, isoprene glycol, butanediol, 1,5-pentanediol, 1,6-hexanediol, 1,9-nonanediol, neopentyl Glycol, ethylene carbonate, propylene carbonate, dioxane, diethyl ether, dialkyl ether, propylene glycol dialkyl ether, polyethylene glycol dialkyl ether, polypropylene glycol dialkyl ether, 3-methyl-2-oxazolidinone, acetonitrile , glutarodinitrile, methoxyacetonitrile, propionitrile, and benzonitrile. The composite material according to claim 1, wherein the gel is an organogel or hydrogel. The composite material according to claim 1, wherein the insulating elastomer is a silicone elastomer. The composite material of claim 1, wherein the insulating elastomer is one or more selected from the group consisting of silicone rubber, polydimethylsiloxane (PDMS), polyvinylidene fluoride (PVDF), and polytetrafluoroethylene (PTFE). . The composite material according to claim 1, which has a fibrous, plate-like, or granular structure. The composite material according to claim 1, which is a triboelectric power generation device. Preparing an ion conductive gel precursor solution containing a matrix polymer monomer, a cross-linking agent, an electrolyte, and a solvent;
Injecting the ion conductive gel precursor solution into the insulating elastomer layer; and
A method for producing the composite material according to any one of claims 1 to 12, comprising polymerizing monomers of the matrix polymer. The method of claim 13, further comprising forming a coating layer on the surface of the insulating elastomer layer. The method of claim 13, wherein the polymerization is polymerization by ultraviolet irradiation. A fabric woven using the composite material according to claim 1. A patch comprising at least one of the composite material according to claim 1 and the fabric according to claim 16. The patch according to claim 17, which is used for skin regeneration, wound healing, or wrinkle improvement.

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