KR102638891B1 - Non-rinse type liquid sterilizing and cleaning agent composition - Google Patents

Abstract

(A) at least one of a carboxyvinyl polymer and an alkyl-modified carboxyvinyl polymer, (B) ethanol, (C) polyoxyethylene hydrogenated castor oil having an average added mole number of ethylene oxide of 20 to 200, and (D) It contains at least one quaternary ammonium compound selected from benzalkonium chloride, cetylpyridinium chloride, and benzethonium chloride, and (E) potassium hydroxide, and the content of the components (A) to (C) is set to a predetermined amount. A non-washable type liquid sterilizing and cleaning agent composition is provided that is within the range, the mass ratio (A/C) is 1.0 or more and 10 or less, and the pH at 25°C is 7 or more and 11 or less.

Description

Non-rinse type liquid sterilizing and cleaning agent composition

The present invention relates to a non-rinse type liquid disinfectant detergent composition.

Conventionally, liquid sterilizing and cleaning agent compositions used in finger disinfectants and the like are required to have sterilizing power and to be excellent in low skin irritation, quick drying, storage stability, etc.

In this regard, for example, a gel-like finger sterilizing cleanser composition has been proposed that has sterilizing power, low skin irritation, and excellent low-temperature storage stability, but is insufficient in terms of quick drying and ease of use (for example, patent documents 1).

In addition, a wash-off type sterilizing cleanser composition has been proposed that has sterilizing power, has low skin irritation, is difficult to run off from the hands, and is excellent in drying quickly, but it is insufficient in that it does not dry the skin of the hands (e.g. (see patent document 2).

Therefore, although the gel-like finger sterilizing cleanser composition and the sterilizing cleanser composition have sterilizing power and improved low skin irritation, they are insufficient for both quick drying, ease of use, and no drying of the hand skin.

From this background, it has excellent sterilizing power, is difficult to drip off the hand, is not sticky when drying, dries quickly, does not dry the skin of the hands, is excellent in low-temperature storage stability and ease of use, and has excellent odor stability over time. There is a need to provide a liquid disinfectant detergent composition of this good non-rinse type.

Japanese Patent Publication No. 2001-261550 Japanese Patent Publication No. 2014-9201

The present invention aims to solve the above-mentioned problems in the prior art and achieve the following objectives. That is, the present invention has excellent sterilizing power, is difficult to drip off the hand, is not sticky when drying, dries quickly, does not dry the skin of the hands, is excellent in low-temperature storage stability and ease of use, and has excellent odor stability over time. The object is to provide a good non-rinse type liquid sterilizing detergent composition.

In order to solve the above problem, the present inventor conducted intensive studies and found that the average addition of at least one of (A) a carboxyvinyl polymer and an alkyl-modified carboxyvinyl polymer, (B) ethanol, and (C) ethylene oxide. Polyoxyethylene hydrogenated castor oil having a mole number of 20 to 200, (D) at least one quaternary ammonium compound selected from benzalkonium chloride, cetylpyridinium chloride, and benzethonium chloride, and (E) potassium hydroxide. Contains, the content of the component (A) is 0.1% by mass to 0.25% by mass, the content of the component (B) is 25% by mass to 35% by mass, and the content of the component (C) is 0.02% by mass. It is 0.2% by mass or less, and the mass ratio (A/C) of the content (% by mass) of the component (A) and the content (% by mass) of the component (C) is 1.0 or more and 10 or less, and at 25 ° C. A non-rinse liquid sterilizing cleanser composition with a pH of 7 or more and 11 or less has excellent sterilizing power due to the synergistic effect of each ingredient, has difficulty flowing from the hand, does not feel sticky when drying, dries quickly, and is gentle on the skin of the hands. It was found that there was no dryness, excellent low-temperature storage stability, and ease of use, and good odor stability over time.

The present invention is based on the above findings by the present inventor, and means for solving the above problems are as follows. in other words,

<1> (A) at least one of a carboxyvinyl polymer and an alkyl-modified carboxyvinyl polymer,

(B) ethanol,

(C) polyoxyethylene hydrogenated castor oil having an average added mole number of ethylene oxide of 20 to 200,

(D) at least one quaternary ammonium compound selected from benzalkonium chloride, cetylpyridinium chloride, and benzethonium chloride;

(E) Contains potassium hydroxide,

The content of the component (A) is 0.1 mass% or more and 0.25 mass% or less,

The content of the component (B) is 25% by mass or more and 35% by mass or less,

The content of the component (C) is 0.02% by mass or more and 0.2% by mass or less,

The mass ratio (A/C) of the content (% by mass) of the component (A) and the content (% by mass) of the component (C) is 1.0 or more and 10 or less,

It is a liquid sterilizing and cleaning agent composition of a non-rinsable type, characterized in that the pH at 25°C is 7 or more and 11 or less.

<2> (F) The non-rinsable type liquid sterilizing and cleaning agent composition according to <1> above, further containing a polyhydric alcohol.

<3> The non-rinsable type liquid sterilizing and cleaning agent composition according to <2> above, wherein the component (F) is sorbitol.

<4> The non-washable type liquid sterilizing and cleaning agent composition according to any one of <2> to <3> above, wherein the content of the component (F) is 0.1% by mass or more and 1% by mass or less.

<5> The non-washable type liquid sterilizing and cleaning agent composition according to any one of <1> to <4> above, wherein the viscosity at 25°C is 100 mPa·s or more and 6,000 mPa·s or less.

<6> The non-washable type liquid sterilizing and cleaning agent composition according to any one of <1> to <5> above, wherein the content of the component (D) is 0.03% by mass or more and 0.15% by mass or less.

<7> The non-washable type liquid sterilizing and cleaning agent composition according to any one of <1> to <6> above, wherein the content of the component (E) is 0.03% by mass or more and 0.14% by mass or less.

<8> The aqueous solution containing 0.2% by mass of the component (A) is neutralized with sodium hydroxide, and the viscosity at 20°C when the pH is set to 7.0 or more and 7.5 or less is 4,000 mPa·s or more and 32,000 mPa·s or less. It is a non-rinsable type liquid sterilizing and cleaning agent composition according to any one of <1> to <7>.

According to the present invention, the above-mentioned object can be achieved by solving the above-mentioned problems in the related art, has excellent sterilizing power, is difficult to drip off the hand, does not feel sticky when drying, dries quickly, and prevents dryness of the skin of the hands. It is possible to provide a liquid sterilizing and cleaning agent composition of a non-rinsable type that is free from odor, is excellent in low-temperature storage stability, and is easy to use, and has good odor stability over time.

(No-rinse type liquid sterilizing and cleaning agent composition)

The non-rinse type liquid sterilizing detergent composition (hereinafter sometimes abbreviated as “liquid sterilizing detergent composition”) of the present invention contains at least one of (A) a carboxyvinyl polymer and an alkyl-modified carboxyvinyl polymer, and (B) ) Ethanol, (C) polyoxyethylene hydrogenated castor oil, (D) quaternary ammonium compound, (E) potassium hydroxide, and (F) polyhydric alcohol, if necessary, Contains additional ingredients.

<(A) Carboxyvinyl polymer, and alkyl-modified carboxyvinyl polymer>

At least one of the carboxyvinyl polymer and the alkyl-modified carboxyvinyl polymer of the component (A) is contained to improve the viscosity, the difficulty of slipping off the hand, and the absence of dryness of the hand skin.

Examples of the carboxyvinyl polymer of component (A) include polymers of acrylic acid.

Examples of the alkyl-modified carboxyvinyl polymer of component (A) include copolymers of acrylic acid and alkyl methacrylate (carbon number of alkyl group: 10 to 30).

As the component (A), one type may be used alone, or two or more types with different viscosities may be used in combination.

The viscosity of the carboxyvinyl polymer and the alkyl-modified carboxyvinyl polymer of component (A) is not particularly limited and can be appropriately selected depending on the purpose, but in terms of difficulty in flowing down from the hand and no stickiness when drying. Based on the measurement method described in Oewon-kyu's Carboxyvinyl Polymer Viscosity, component (A) was dried at 105°C for 3 hours, 0.4 g was taken from the dried component (A), 200 mL of water was added, and if possible, the foam was added. After dispersing to prevent nitrous oxide from entering, dissolve 9 g of sodium hydroxide in purified water and add 50 mL of sodium hydroxide solution to adjust the pH to 7.0 or more and 7.5 or less. After that, leave to stand for at least 10 hours to remove foam, and incubate at 20°C. The viscosity when performing the test is preferably 4,000 mPa·s or more and 32,000 mPa·s or less. If the viscosity is less than 4,000 mPa·s, the viscosity of the liquid sterilizing and cleaning agent composition may decrease, and the difficulty in flowing down from the hand may become insufficient. If the viscosity exceeds 32,000 mPa·s, the lack of stickiness when drying and the drying speed may be insufficient.

The viscosity of the carboxyvinyl polymer and alkyl-modified carboxyvinyl polymer of the component (A) can be measured, for example, using a viscometer (device name: BM type viscometer, manufactured by Tokyo Keiki Co., Ltd.) or a viscometer (device name: BL type viscometer, manufactured by Tokyo Keiki Co., Ltd.). It can be measured using a device such as a Kaisha product.

In an environment with a sample temperature of 20°C, if the viscosity of the component (A) is 4,000 mPa·s or more but less than 10,000 mPa·s, measure the viscosity after 1 minute at a rotation speed of 12 rpm using the No. 3 rotor. can do.

Additionally, in an environment with a sample temperature of 20°C, if the viscosity of the component (A) is 10,000 mPa·s or more and 32,000 mPa·s or less, use the rotor No. 4 and measure the viscosity after 1 minute at a rotation speed of 12 rpm. It can be measured.

As the carboxyvinyl polymer and alkyl-modified carboxyvinyl polymer of the component (A), commercially available products may be used as appropriate.

The carboxyvinyl polymer of component (A) using the commercially available carboxyvinyl polymer is not particularly limited and can be appropriately selected depending on the purpose, for example, carboxyvinyl polymer (brand name: Carbopol (registered trademark) 981, Nippon 0.2% by mass aqueous solution of Lubrizol Co., Ltd. (Neutralization conditions: sodium hydroxide, pH: 7.0 or more and 7.5 or less, viscosity at 20°C: 4,000 mPa·s or more and 7,500 mPa·s or less), carboxyvinyl polymer ( Product name: Carbopol (registered trademark) ETD2050, manufactured by Nippon Lubrizol Co., Ltd. 0.2% by mass aqueous solution (neutralization conditions: sodium hydroxide, pH: 7.0 or more and 7.5 or less, viscosity at 20°C: 6,000 mPa·s or more 14,000 mPa·s or less), 0.2% by mass aqueous solution of carboxyvinyl polymer (brand name: Carbopol (registered trademark) 980, manufactured by Nippon Lubrizol Co., Ltd.) (neutralization conditions: sodium hydroxide, pH: 7.0 or more and 7.5 or less, 20 Viscosity in °C: 16,000 mPa·s or more and 28,000 mPa·s or less), 0.2% by mass aqueous solution of carboxyvinyl polymer (brand name: Carbopol (registered trademark) Ultrez10, manufactured by Nippon Lubrizol Co., Ltd.) (neutralization conditions: Sodium hydroxide, pH: 7.0 or more and 7.5 or less, viscosity at 20°C: 12,000 mPa·s or more and 29,000 mPa·s or less). These may be used individually, or two or more types may be used together.

The alkyl-modified carboxyvinyl polymer of component (A) using the commercially available alkyl-modified carboxyvinyl polymer is not particularly limited and can be appropriately selected depending on the purpose, for example, alkyl-modified carboxyvinyl polymer (product name: Carbopol ( Registered trademark) 1382, manufactured by Nippon Lubrizol Co., Ltd.) 0.2% by mass aqueous solution (neutralization conditions: sodium hydroxide, pH: 7.0 or more and 7.5 or less, viscosity at 20°C: 14,000 mPa·s or more and 32,000 mPa·s or less ), 0.2 mass% aqueous solution of alkyl-modified carboxyvinyl polymer (brand name: Carbopol (registered trademark) ETD2020, manufactured by Nippon Lubrizol Co., Ltd.) (neutralization conditions: sodium hydroxide, pH: 7.0 to 7.5, at 20°C viscosity: 14,000 mPa·s or more and 32,000 mPa·s or less). These may be used individually, or two or more types may be used together.

Among these, a 0.2% by mass aqueous solution (neutralization conditions: hydroxide) of carboxyvinyl polymer (brand name: Carbopol (registered trademark) 980, manufactured by Nippon Lubrizol Co., Ltd.) in terms of non-stickiness when drying and low-temperature storage stability. Sodium, pH: 7.0 or more and 7.5 or less, viscosity at 20°C: 16,000 mPa·s or more and 28,000 mPa·s or less), alkyl-modified carboxyvinyl polymer (brand name: Carbopol (registered trademark) 1382, Nippon Lubrizol Co., Ltd.) 0.2% by mass aqueous solution (neutralization conditions: sodium hydroxide, pH: 7.0 to 7.5, viscosity at 20°C: 14,000 mPa·s to 32,000 mPa·s), alkyl-modified carboxyvinyl polymer (brand name: Carbo) 0.2% by mass aqueous solution of Pol (registered trademark) ETD2020, manufactured by Nippon Lubrizol Co., Ltd. (Neutralization conditions: sodium hydroxide, pH: 7.0 to 7.5, viscosity at 20°C: 14,000 mPa·s to 32,000 mPa·s s or less) is preferable.

The content of the carboxyvinyl polymer and alkyl-modified carboxyvinyl polymer of the component (A) is 0.1% by mass or more and 0.25% by mass or less based on the total amount of the liquid sterilizing and cleaning agent composition, and is difficult to drip off the hand and does not feel sticky when dry. From the viewpoint of drying quickly and preventing dryness of the skin of the hands, 0.12% by mass or more and 0.2% by mass or less are preferable. If the content is less than 0.1% by mass, it may be difficult to drain from the hands and the skin of the hands may be insufficiently dry. If the content exceeds 0.25% by mass, the lack of stickiness when drying and the speed of drying may be insufficient.

<(B)ethanol>

The ethanol of the component (B) is contained to improve the absence of stickiness when drying and the speed of drying.

The ethanol of the component (B) is not particularly limited and can be appropriately selected depending on the purpose, for example, anhydrous ethanol, 95 volume% ethanol (standard value 95.0 volume% to 95.5 volume%, content as anhydrous ethanol), etc. can be mentioned. These may be used individually, or two or more types may be used together.

As the ethanol of the component (B), a commercially available product may be used.

The absolute ethanol conversion value (content converted to anhydrous ethanol (mass %)) when using the above 95 volume% ethanol is the formula (1) below (document 038-1309.pdf from the Pharmaceutical and Medical Device General Organization, an independent administrative corporation) and It can be obtained using equation (2).

· Mass % of ethanol = volume %

=(95×0.79422)/0.81639

=92.42

· Anhydrous ethanol content (mass %) = 95 volume% ethanol content (mass %) × 92.42/100... Equation (2)

The ethanol content of the component (B) above is 25% by mass or more as anhydrous ethanol based on the total amount of the liquid sterilizing and cleaning agent composition in terms of no stickiness when drying, no drying of the skin on the hands, and low-temperature storage stability. 35 It is % by mass or less, and is preferably 30% by mass or more and 35% by mass or less. If the content is less than 25% by mass, the lack of stickiness when drying and the drying speed may be insufficient. If the content exceeds 35% by mass, the dryness of the hand skin and the low-temperature storage stability may be insufficient.

<(C) Polyoxyethylene hydrogenated castor oil>

The polyoxyethylene hydrogenated castor oil of the component (C) has an average added mole number of ethylene oxide of 20 or more and 200 or less, and is contained to improve low-temperature storage stability.

The average added mole number of ethylene oxide in the polyoxyethylene hydrogenated castor oil of the component (C) is preferably 20 or more and 200 or less, and is preferably 40 or more and 60 or less. If the average added mole number of the ethylene oxide is less than 20, the lack of stickiness when drying and the low-temperature storage stability may be insufficient. It is difficult to obtain commercially available products having an average added mole number of ethylene oxide exceeding 200.

The polyoxyethylene hydrogenated castor oil of the component (C) is not particularly limited and can be appropriately selected depending on the purpose, for example, polyoxyethylene hydrogenated castor oil (average added mole number of ethylene oxide: 20), polyoxyethylene Hydrogenated castor oil (average added moles of ethylene oxide: 30), polyoxyethylene hydrogenated castor oil (average added moles of ethylene oxide: 40), polyoxyethylene hydrogenated castor oil (average added moles of ethylene oxide: 50), polyoxyethylene Ethylene hydrogenated castor oil (average added moles of ethylene oxide: 60), polyoxyethylene hydrogenated castor oil (average added moles of ethylene oxide: 80), polyoxyethylene hydrogenated castor oil (average added moles of ethylene oxide: 100), poly Oxyethylene hydrogenated castor oil (average added mole number of ethylene oxide: 150), polyoxyethylene hydrogenated castor oil (average added mole number of ethylene oxide: 200), etc. These may be used individually, or two or more types may be used together.

Among these, polyoxyethylene hydrogenated castor oil (average added moles of ethylene oxide: 40), polyoxyethylene hydrogenated castor oil (average added moles of ethylene oxide: 50), polyoxyethylene hydrogenated castor oil (average added moles of ethylene oxide) :60) is preferable, and polyoxyethylene hydrogenated castor oil (average added mole number of ethylene oxide: 40) is more preferable.

As the polyoxyethylene hydrogenated castor oil of the component (C), a commercially available product may be used as appropriate.

The above commercial products are not particularly limited and can be appropriately selected depending on the purpose, for example, polyoxyethylene hydrogenated castor oil (brand name: EMALEX HC-20, manufactured by Nippon Emulsion Co., Ltd., average added mole number of ethylene oxide: 20) , polyoxyethylene hydrogenated castor oil (brand name: EMALEX HC-30, manufactured by Nippon Emulsion Co., Ltd., average added mole number of ethylene oxide: 30), polyoxyethylene hydrogenated castor oil (brand name: EMALEX HC-40, manufactured by Nippon Emulsion Co., Ltd.) Manufactured by Kaisha, average added moles of ethylene oxide: 40), polyoxyethylene hydrogenated castor oil (brand name: EMALEX HC-50, manufactured by Nippon Emulsion Co., Ltd., average added moles of ethylene oxide: 50), polyoxyethylene hydrogenated castor oil (Product name: EMALEX HC-60, manufactured by Nippon Emulsion Co., Ltd., average added mole number of ethylene oxide: 60), polyoxyethylene hydrogenated castor oil (brand name: EMALEX HC-80, manufactured by Nippon Emulsion Co., Ltd., average of ethylene oxide) Added moles: 80), polyoxyethylene hydrogenated castor oil (brand name: EMALEX HC-100, manufactured by Nippon Emulsion Co., Ltd., average added moles of ethylene oxide: 100), polyoxyethylene hydrogenated castor oil (brand name: Brownon CW- 150, Aokiyushi Kogyo Co., Ltd., average added moles of ethylene oxide: 150), polyoxyethylene hydrogenated castor oil (brand name: Brownon CW-200, Aokiyushi Kogyo Co., Ltd., average added moles of ethylene oxide: 200), etc. These may be used individually, or two or more types may be used together.

The content of polyoxyethylene hydrogenated castor oil in the component (C) is 0.02% by mass or more and 0.2% by mass or less based on the total amount of the liquid sterilizing detergent composition in terms of non-stickiness when drying, quick drying, and low-temperature storage stability, and 0.03% by mass. % by mass or more and 0.1 mass % or less is preferable. If the content is less than 0.02% by mass, low-temperature storage stability may become insufficient. If the content exceeds 0.2% by mass, the lack of stickiness when drying and the speed of drying may become insufficient.

[Mass ratio (A/C)]

The mass ratio (A/C) of the content (% by mass) of the component (A) and the content (% by mass) of the component (C) is in terms of no stickiness when drying, quick drying, and low-temperature storage stability. It is 1.0 or more and 10 or less, and 2 or more and 6 or less are preferable. If the mass ratio is less than 1.0, the lack of stickiness when drying and the drying speed may be insufficient. If the mass ratio exceeds 10, low-temperature storage stability may become insufficient.

<(D) Quaternary ammonium compound>

The quaternary ammonium compound of component (D) contains at least one selected from benzalkonium chloride, cetylpyridinium chloride, and benzethonium chloride, and is contained to improve sterilizing power.

The quaternary ammonium compounds may be used individually, or two or more types may be used in combination. Among these, benzalkonium chloride and benzethonium chloride are preferable in terms of sterilizing power and lack of stickiness when drying.

The content of the quaternary ammonium compound in the component (D) is 0.03% by mass or more and 0.15% by mass based on the total amount of the sterilizing detergent composition in terms of sterilizing power, difficulty in sliding off the hands, non-drying of the hand skin, and low-temperature storage stability. The following is preferable, and 0.04 mass% or more and 0.1 mass% or less is more preferable. If the content is 0.03% by mass or more, the sterilizing power is good. If the content is 0.15% by mass or less, it is difficult to drip off the hands, the skin of the hands does not dry out, and the low-temperature storage stability is good.

<(E) Potassium hydroxide>

The potassium hydroxide of the component (E) is contained in order to prevent it from slipping off from hands and to improve low-temperature storage stability.

As potassium hydroxide of the component (E), a commercially available product may be used as appropriate.

The above commercial products are not particularly limited and can be appropriately selected depending on the purpose, for example, brand name: caustic potash (liquid, manufactured by Asahi Glass Co., Ltd.), brand name: caustic potash (solid, manufactured by Asahi Glass Co., Ltd.) ), etc.

By adding the potassium hydroxide of component (E) to the liquid sterilizing and detergent composition, the pH of the liquid sterilizing and detergent composition can be adjusted.

The content of potassium hydroxide in the component (E) above is 0.03% by mass or more and 0.14% by mass or less in terms of pure content based on the total amount of the liquid sterilizing and cleaning agent composition in terms of difficulty in dripping from hands, low-temperature storage stability, and no drying of the skin of the hands. is preferable, and 0.03 mass% or more and 0.12 mass% or less is more preferable. If the content is 0.03% by mass or more, it is difficult to slip off the hand and has good low-temperature storage stability. If the content is 0.14% by mass or less, it has good resistance to slipping off the hands, low-temperature storage stability, and no dryness of the skin of the hands.

<(F)polyhydric alcohol>

The polyhydric alcohol of the component (F) is preferably contained in order to improve the absence of dryness of the skin of the hands.

The polyhydric alcohol of the component (F) is not particularly limited and can be appropriately selected depending on the purpose, for example, glycerin, propylene glycol, dipropylene glycol, ethylene glycol, 1,3-butylene glycol, sorbitol, diethylene. Glycol, isopropylene glycol, polyethylene glycol (average molecular weight: 200 or more and 2,000 or less), etc. These may be used individually, or two or more types may be used together. Among these, sorbitol is preferable because it does not dry out the skin of the hands.

In addition, the average molecular weight of the polyethylene glycol represents the average molecular weight described in the Quasi-Drug Raw Material Standard 2006 (published by Yakuji Nippo Corporation).

The content of the polyhydric alcohol in the component (F) is preferably 0.1% by mass or more and 1% by mass or less in terms of no stickiness when drying and no dryness of the skin of the hands with respect to the entire amount of the liquid disinfectant and detergent composition. If the content is 0.1% by mass or more, it is good that the skin of the hands does not dry out. If the content is 1% by mass or less, there is no stickiness when drying and the drying speed is good.

<Other ingredients>

In addition to each of the components (A) to (F) above, the non-rinse-off type liquid sterilizing and detergent composition of the present invention includes components commonly used in liquid sterilizing and detergent compositions, etc., as necessary, within a range that does not impair the effect of the present invention. Can be mixed as other ingredients.

There are no particular restrictions on the other components, and they can be appropriately selected depending on the purpose, for example, water, water-soluble polymers other than the component (A), oils, silicones, lanolin derivatives, protein derivatives, drugs such as vitamins, and the like. Disinfectants and preservatives other than the component (D), pH adjusters other than the component (E), antioxidants, metal blockers, ultraviolet absorbers, animal and plant extracts or derivatives thereof, pigments, fragrances, etc. These may be used individually, or two or more types may be used together.

The content of the other components mentioned above can be a commonly used content within a range that does not impair the effect of the present invention.

-Manufacturing method-

There is no particular limitation on the method for producing the above-mentioned non-rinse type liquid sterilizing and cleaning agent composition, and can be appropriately selected depending on the purpose. For example, in an environment at room temperature (e.g., 25°C), the above (A) is added to water. ) Add the ingredients in small amounts while stirring and disperse evenly to prepare dispersion 1. Next, solution 1 is prepared by adding and dissolving the component (C), the component (D), and, if necessary, the component (F) in water. Thereafter, the dispersion 1, the component (B), the solution 1, and, if necessary, the other components are mixed, and each component is dissolved while stirring. After that, the above-mentioned (E) component is added while stirring, and a method of adjusting the pH to a predetermined level is included. Additionally, it is preferable to add water so that the total amount of each liquid disinfectant and detergent composition is 100% by mass.

The above-mentioned non-rinse type liquid sterilizing and cleaning agent composition may be prepared using an apparatus. The above device is not particularly limited and can be appropriately selected depending on the purpose. Examples include a stirring device having a shear force and a stirring blade capable of mixing the whole.

The stirring blade is not particularly limited and can be appropriately selected depending on the purpose, and examples include propellers, turbines, and dispers.

-pH-

The non-rinse type liquid sterilizing and cleaning agent composition has a pH of 7 or more and 11 or less at 25°C, and is 7 or more and 9 or less in terms of difficulty in flowing off from hands, non-drying of the hand skin, and low-temperature storage stability. desirable. If the pH is less than 7, low-temperature storage stability decreases. If the pH exceeds 11, it is difficult to drain from the hand, the skin of the hand does not dry, and the low-temperature storage stability decreases.

The pH can be measured under a 25°C environment, for example, with a glass electrode type hydrogen ion concentration indicator (device name: pH meter HM-30R type, manufactured by Doa DK Co., Ltd., electrode type: GST-5721). .

-courage-

The non-rinse type liquid disinfectant detergent composition can be used by filling it in a container.

The container is not particularly limited and can be appropriately selected depending on the purpose, but a pump dispenser container is preferable.

The pump dispenser container is not particularly limited and can be appropriately selected depending on the purpose, and examples include a pump dispenser container (nozzle diameter (inner diameter): 3.5 mm, discharge amount: 0.5 mL).

As the pump dispenser container, a commercially available product may be used as appropriate. Examples of the commercially available products include pump dispenser containers (manufactured by Yoshino Kogyosho Co., Ltd.).

-viscosity-

The viscosity of the above-mentioned non-rinse-off type liquid sterilizing and cleaning agent composition is 100 mPa·s or more and 6,000 mPa·s or less in a 25°C environment in terms of difficulty in flowing from the hand, no stickiness when drying, and quick drying. It is preferable, and 300 mPa·s or more and 4,000 mPa·s or less are more preferable.

The viscosity of the above-mentioned non-wash-out type liquid sterilizing detergent composition can be measured using, for example, a viscometer (device name: BM type viscometer, manufactured by Tokyo Keiki Co., Ltd.).

When the viscosity of the liquid sterilizing and cleaning agent composition is 40 mPa·s or more and less than 3,000 mPa·s, in an environment with a sample temperature of 25°C, using the BM adapter and the rotor No. 3, rotation speed: 30 rpm for 1 minute. Viscosity can be measured.

Additionally, when the viscosity of the liquid sterilizing and cleaning agent composition is 3,000 mPa·s or more and 6,000 mPa·s or less, in an environment with a sample temperature of 25°C, using a BM adapter and a No. 4 rotor, rotation speed: 30 rpm for 1 minute. Viscosity after elapse can be measured.

-How to use-

The method of using the liquid sterilizing detergent composition of the non-rinse type does not require washing off with water or the like after using the liquid sterilizing detergent composition on the skin of the hands. Specifically, there is no need to rub the liquid disinfectant and detergent composition on the palms and backs of the hands and then rinse them with tap water or the like.

By not washing off the liquid sterilizing detergent composition, sterilizing power and simplicity of use are improved.

-Usage-

There are no particular restrictions on the non-rinse-off type liquid sterilizing and cleaning agent composition, and it can be appropriately selected depending on the purpose, and can be suitably used, for example, as a hand skin disinfectant. Additionally, the non-rinse type liquid disinfectant cleaning agent composition can be used on body parts other than hands. Application sites include, for example, hospitals, care facilities, kitchen use, etc., and it is also suitable for use at home.

Example

Hereinafter, examples of the present invention will be described, but the present invention is not limited to these examples in any way. In addition, the content of each component described in the Examples and Comparative Examples is all converted to pure content. However, for component (B), 95.3% by volume ethanol was used, and the actual blending amount (% by mass) of 95.3% by volume ethanol and the conversion value to absolute ethanol (content (% by mass) converted to anhydrous ethanol) were written together.

(Examples 1 to 32 and Comparative Examples 1 to 23)

The liquid sterilizing and detergent compositions of Examples 1 to 32 and Comparative Examples 1 to 23 were prepared according to the composition and content (% by mass) shown in Tables 1 to 7 below according to the following production method.

-Preparation of liquid disinfectant cleaning agent composition-

In an environment of 25°C, the component (A) or the comparative component (A) was added in small amounts while stirring to an appropriate amount of purified water and dispersed uniformly to prepare dispersion liquid 1. Next, add component (C) or comparison component (C), component (D) or comparison component (D), and component (F) to purified water that constitutes 1% by mass of the total amount of the liquid sterilizing and cleaning agent composition finally obtained. and dissolved to prepare solution 1. After that, the dispersion 1, the component (B), and the solution 1 were mixed in this order, and each component was dissolved while stirring to add purified water to make 92% by mass of the total amount of the liquid sterilizing and detergent composition finally obtained. After that, component (E) or comparative component (E) was added while stirring, and the pH was adjusted to a predetermined level. Additionally, purified water was added so that the total content of each liquid sterilizing and detergent composition was 100% by mass, thereby obtaining a transparent liquid sterilizing and detergent composition.

Additionally, a propeller was used as a stirring blade, and stirring was performed using a three-one motor (brand name: HEIDON BL1200, manufactured by Shinto Chemical Co., Ltd.). In addition, the pH was measured at 25°C using a pH meter (device name: HM-30R type, manufactured by Doa DK Co., Ltd.).

Regarding viscosity, in an environment at 25°C, use a viscometer (device name: BM type viscometer, manufactured by Tokyo Keiki Co., Ltd.), and if it is 40 mPa·s or more and less than 3,000 mPa·s, use a BM adapter and No. 3. Using the rotor, the viscosity was measured after 1 minute at a rotation speed of 30 rpm. In addition, in the case of 3,000 mPa·s or more and 6,000 mPa·s or less, the BM adapter and No. 4 rotor were used to measure the viscosity after 1 minute at a rotation speed of 30 rpm.

Regarding the non-washable liquid sterilizing and cleaning agent compositions of Examples 1 to 32 and Comparative Examples 1 to 22, “sterilizing power”, “difficult to drip off hands”, “no stickiness when drying”, and “drying”. “Fast”, “No drying of hand skin”, “Low-temperature storage stability”, “Simplicity during use”, and “Odor stability over time” were evaluated by the following methods.

The rinse-off type liquid sterilizing detergent composition of Comparative Example 23 was compared to the non-wash-off type liquid sterilizing detergent composition above in terms of “sterilizing power,” “difficult to drip off hands,” “low-temperature storage stability,” and “odor stability over time.” It was evaluated by the same method as for the composition. In addition, “no stickiness when drying,” “drying quickly,” “no drying of hand skin,” and “ease of use” were evaluated by a different method from the above-mentioned non-rinse type liquid sterilizing detergent composition. did. Details will be described later.

The results of Examples 1 to 32 and Comparative Examples 1 to 23 are shown in Tables 1 to 7 below.

<Sterilization power>

Escherichia coli NBRC3972 (obtained from the Product Evaluation Foundation, an independent administrative corporation) was used as the target bacterium, and the sterilizing power of the liquid sterilizing and cleaning agent composition was evaluated by the quantitative suspension method shown below.

The above E. coli was cultured for 24 hours at 37°C under aerobic conditions using SCD agar medium (manufactured by Nippon Seiyaku Co., Ltd.). Next, an appropriate amount of colonies formed on the SCD agar medium were scraped and suspended in physiological saline (manufactured by Otsuka Seiyaku Co., Ltd.) to adjust the bacterial concentration to 10 ⁸ cfu/mL, which was used as a test bacterial solution. Also, cfu means colony forming unit.

Next, 0.005 mL of the test bacterial solution was added to 0.495 mL of the obtained liquid sterilizing detergent composition and mixed, and after 30 seconds, the mixed solution was immediately diluted 10 times in SCDLP liquid culture paper (manufactured by Nippon Seiyaku Co., Ltd.) and inactivated. Additionally, the inactivated solution was diluted 100-fold, 1,000-fold, and 10,000-fold in SCDLP medium, and dilutions were performed in steps of 10 times. Afterwards, 1 mL of each activated solution diluted to each concentration was seeded (n=3) on SCDLP agar medium (Nippon Seiyaku Co., Ltd., 9 cm Shaale), and 37 cells were grown under aerobic conditions by the mixed plate culture method. It was cultured for 24 hours at ℃. After culturing, the total number of colonies formed was counted, and the number of remaining viable bacteria was measured. When no colonies were observed, the number of remaining viable bacteria was set to less than 10 cfu/mL, the detection limit. The sterilizing power was scored based on the following judgment criteria from the measured number of remaining viable bacteria. Based on the average value of the above scores, “sterilizing power” was evaluated based on the following evaluation criteria.

-Judgment criteria-

5 points: Remaining viable bacteria count is less than 10 cfu/mL (less than detection limit)

4 points: Remaining viable bacteria count is 10 cfu/mL or more but less than 100 cfu/mL

3 points: Remaining viable bacteria count is 100 cfu/mL or more but less than 1,000 cfu/mL

2 points: Remaining viable bacteria count is 1,000 cfu/mL or more but less than 10,000 cfu/mL

1 point: Remaining viable bacteria count is more than 10,000 cfu/mL

-Evaluation standard-

◎: The average value of the above scores is 4.0 points or more and 5.0 points or less.

○: The average value of the above scores is 3.0 points or more and less than 4.0 points.

△: The average value of the above scores is 2.0 points or more and less than 3.0 points.

×: The average value of the above scores is less than 2.0 points

<Difficult to let go from hand>

In an environment of 25°C, 10 professional panelists (5 men, 5 women) took 0.5 g of the obtained liquid sterilizing and cleaning agent composition on the center of their dry right palms and then rubbed the liquid on the palms and backs of their hands with both hands. Regarding the difficulty of the sterilizing detergent composition flowing from the hands, the difficulty of flowing from the hands is scored based on the judgment criteria below, and the average value of the scores is calculated as "difficult to drip from the hands" based on the evaluation criteria below. evaluated.

-Judgment criteria-

5 points: Very difficult to shed

4 points: Difficult to drain

3 points: Slightly difficult to drain

2 points: Slightly prone to dripping

1 point: Easy to drip

-Evaluation standard-

◎: The average value of the above scores is 4.0 points or more and 5.0 points or less.

○: The average value of the above scores is 3.0 points or more and less than 4.0 points.

△: The average value of the above scores is 2.0 points or more and less than 3.0 points.

×: The average value of the above scores is less than 2.0 points

<No stickiness when drying, quick drying, no drying of the skin on your hands, and ease of use>

In an environment of 25°C, 10 professional panelists (5 men, 5 women) took 0.5 g of the obtained liquid sterilizing and cleaning agent composition in the center of their dry right palms and applied one of the following usage methods a and usage methods b. A liquid sterilizing detergent composition was used by either method. No stickiness when drying, quick drying, no drying of the skin on the hands, and ease of use are scored based on the judgment criteria below, and the average value of the scores above is used to determine "when drying" based on the evaluation criteria below. 'No stickiness', 'dries quickly', 'no dryness of hand skin', and 'ease of use' were evaluated.

· Method of use a (Examples 1 to 32 and Comparative Examples 1 to 22)

The liquid disinfectant cleanser composition obtained in the center of the dry right palm was rubbed with both hands on the palm and back of the hand until the professional panelist judged it to be dry.

·Usage method b (Comparative Example 23)

Rub the liquid sterilizing detergent composition obtained in the center of the dry right palm onto the palms and backs of the hands with both hands, wash both hands with tap water (25°C, 2 L/min) before the liquid sterilizing detergent composition dries on both hands, and each professional paneler After determining that it had been washed, the hand was shaken twice to lightly remove moisture from the hand, and then rubbed until the professional panelist judged it to be dry.

-Criteria for judging lack of stickiness when dry-

5 points: Does not feel sticky

4 points: Almost no stickiness

3 points: It feels a little sticky, but it is at a level without any problems.

2 points: Feels sticky

1 point: Feels a strong stickiness

-Evaluation criteria for lack of stickiness when dry-

◎: The average value of the above scores is 4.0 points or more and 5.0 points or less.

○: The average value of the above scores is 3.0 points or more and less than 4.0 points.

△: The average value of the above scores is 2.0 points or more and less than 3.0 points.

×: The average value of the above scores is less than 2.0 points

-Standards for judging how quickly it dries-

5 points: I feel it dries quickly

4 points: I feel that it dries a little quickly.

3 points: It takes some time to dry, but it is at a level without any problems.

2 points: I feel that drying is a bit slow.

1 point: I feel that drying is slow.

-Evaluation criteria for drying quickly-

◎: The average value of the above scores is 4.0 points or more and 5.0 points or less.

○: The average value of the above scores is 3.0 points or more and less than 4.0 points.

△: The average value of the above scores is 2.0 points or more and less than 3.0 points.

×: The average value of the above scores is less than 2.0 points

-Standards for judging the absence of dryness of hand skin-

5 points: Do not feel dryness of the skin of your hands

4 points: I hardly feel any dryness of the skin on my hands.

3 points: I feel the skin on my hands is slightly dry, but it is at a level that is not a problem.

2 points: I feel the skin on my hands is dry.

1 point: I feel the dryness of the skin on my hands strongly.

-Evaluation criteria for absence of dryness of hand skin-

◎: The average value of the above scores is 4.5 points or more and 5.0 points or less.

◎∼○: The average value of the above scores is 4.0 points or more and less than 4.5 points.

○: The average value of the above scores is 3.0 points or more and less than 4.0 points.

△: The average value of the above scores is 2.0 points or more and less than 3.0 points.

×: The average value of the above scores is less than 2.0 points

-Criteria for judging ease of use-

4 points: Feels convenience

3 points: Feels a bit simple

2 points: Neither

1 point: I do not feel convenience

-Evaluation criteria for ease of use-

○: The average value of the above scores is 3.0 points or more and 4.0 points or less.

△: The average value of the above scores is 2.0 points or more and less than 3.0 points.

×: The average value of the above scores is less than 2.0 points

<Cold storage stability>

50 mL of the obtained liquid sterilizing and cleaning agent composition was filled into three 50 mL glass screw vials (Product name: SV-50A, manufactured by Nichiden Rika Glass Co., Ltd.), stored in a constant temperature bath at -5°C for one month, and then subjected to professional panel. One person observed the appearance of the liquid sterilizing and cleaning agent composition with the naked eye, scored the low-temperature storage stability based on the following judgment criteria, and evaluated the "low-temperature storage stability" based on the following evaluation criteria based on the average value of the scores.

-Judgment criteria-

5 points: colorless and transparent

4 points: Almost colorless and transparent

3 points: Although it is slightly cloudy, it is at a level without any problems.

2 points: White cast appears overall.

1 point: White precipitate is seen

-Evaluation standard-

◎: The average value of the above scores is 4.0 points or more and 5.0 points or less.

○: The average value of the above scores is 3.0 points or more and less than 4.0 points.

△: The average value of the above scores is 2.0 points or more and less than 3.0 points.

×: The average value of the above scores is less than 2.0 points

<Odor stability over time>

45 mL of the obtained liquid sterilizing detergent composition was filled into two 50 mL glass screw vials (brand name: SV-50A, manufactured by Nichiden Rika Glass Co., Ltd.), and one was stored in a constant temperature bath at 50°C for one month. Additionally, as a comparison object, the remaining product (standard product) was stored in an environment at 5°C for 1 month. Afterwards, it was taken out from the thermostat, and three professional panelists smelled the liquid sterilizing and cleaning agent composition in an environment of 25°C, compared it with the smell of a standard product stored at 5°C for 1 month, and determined the odor stability over time based on the following judgment criteria. was scored, and the average value of the scores was used to evaluate “odor stability over time” based on the following evaluation criteria.

-Judgment criteria-

5 points: The odor did not change compared to the standard product.

4 points: There was little change in odor compared to the standard product.

3 points: The odor changed slightly compared to the standard product, but there was no unpleasant odor.

2 points: The odor changed compared to the standard product.

1 point: The odor changed significantly compared to the standard product.

-Evaluation standard-

◎: The average value of the above scores is 4.0 points or more and 5.0 points or less.

○: The average value of the above scores is 3.0 points or more and less than 4.0 points.

△: The average value of the above scores is 2.0 points or more and less than 3.0 points.

×: The average value of the above scores is less than 2.0 points

In addition, the raw materials of the liquid disinfectant and detergent composition used in Examples 1 to 32 and Comparative Examples 1 to 23 are shown in Table 8 below.

The viscosity of component (A) in Table 8 above is a 0.2% by mass aqueous solution of pH 7.0 or more and 7.5 or less. Each product is measured using a viscometer (device name: BM type viscometer, manufactured by Tokyo Keiki Co., Ltd.) in an environment with a sample temperature of 20°C. This is a value obtained by measuring the viscosity after 1 minute at a rotation speed of 12 rpm using a BM adapter and a No. 4 rotor.

The non-rinse type liquid sterilizing detergent composition of the present invention has sterilizing power, is difficult to drip from the hand, does not feel sticky when drying, dries quickly, does not dry the skin of the hands, has low temperature storage stability, and is easy to use. It has excellent odor stability over time and can be suitably used, for example, as a hand skin disinfectant. In addition, the above-mentioned non-rinse type liquid sterilizing and cleaning agent composition can also be used for body use, such as for body use. Application sites include, for example, hospitals, care facilities, kitchen use, etc., and it is also suitable for use at home.

Claims (4)

(A) at least one of a carboxyvinyl polymer and an alkyl-modified carboxyvinyl polymer,
(B) ethanol,
(C) polyoxyethylene hydrogenated castor oil having an average added mole number of ethylene oxide of 20 to 200,
(D) at least one quaternary ammonium compound selected from benzalkonium chloride, cetylpyridinium chloride, and benzethonium chloride;
(E) Contains potassium hydroxide,
The content of the component (A) is 0.1 mass% or more and 0.25 mass% or less,
The content of the component (B) is 25% by mass or more and 35% by mass or less,
The content of the component (C) is 0.02% by mass or more and 0.2% by mass or less,
The mass ratio (A/C) of the content (% by mass) of the component (A) and the content (% by mass) of the component (C) is 1.0 or more and 10 or less,
A non-rinse type liquid sterilizing and cleaning agent composition, characterized in that the pH at 25°C is 7 or more and 11 or less. According to claim 1,
(F) A non-rinsable type liquid disinfectant and detergent composition further containing polyhydric alcohol. According to claim 2,
A liquid disinfectant and detergent composition of a non-rinse type wherein the component (F) is sorbitol. According to claim 2 or 3,
A liquid sterilizing and cleaning agent composition of a non-rinsable type, wherein the content of the component (F) is 0.1% by mass or more and 1% by mass or less.