KR102542555B1 - Cosmetic composition for anti-inflammatory and anti-acne comprising vegetable mucin - Google Patents

Abstract

The present invention relates to a cosmetic composition for anti-inflammatory and anti-acne uses, and according to the composition according to one aspect, vegetable mucin or an extract containing the vegetable mucin according to one aspect has an antibacterial effect on acne bacteria, and NO production and TNF-α, which is an inflammatory mediator, expression inhibiting activity, thereby being usefully used in cosmetic compositions or pharmaceutical compositions for improving skin condition.

Description

Cosmetic composition for anti-inflammatory and anti-acne comprising vegetable mucin

It relates to a cosmetic composition for anti-inflammatory and anti-acne.

Acne is a chronic skin disease in which excessive secretion of sebum accumulates in pores and causes an inflammatory response (Omer et al., 2017). Most of them are known as adolescent diseases that occur during puberty, but they are also common skin diseases in adults in their 30s and 40s. The incidence rate of acne among young people (12-24 years old) is 70-87%, and the incidence rate of acne among adults aged 25-34 years is 8%, but acne also occurs in 3% of adults aged 35-44 years (Ahn Seong-gu, ( 2006), acne bible diagnosis and treatment). The direct cause of acne is known as male hormones, and indirect causes include environmental pollution, stress, heredity, drug abuse, and bacterial infection. Testosterone, known as the direct cause, stimulates the sebaceous glands to promote sebum secretion, and the large amount of sebum produced promotes the thickening of dead skin cells on the pore walls, which clogs the pores and prevents the discharge of sebum, resulting in acne.

Also known as acne bacillus , Cutibacterium acnes (scientific name Propionibacterium acnes before 2016) is an anaerobic bacterium that secretes a lipolytic enzyme that breaks down neutral fat in sebum to form free fatty acids. Free fatty acids irritate the skin, causing inflammation in the walls of the hair follicles or cells around the pores. C. acnes stimulates keratinocytes by inducing an inflammatory response to produce a large amount of reactive oxygen species (ROS), which causes a deficiency of substances inhibiting the growth of C. acnes It accelerates skin aging by destroying antioxidants in the skin, initiating lipid peroxidation, oxidizing proteins and DNA, inducing wrinkles and melanin production by chain scission and abnormal cross-linking of connective tissue.

Representative substances that can improve acne symptoms include antibiotics such as tetracycline, deoxycycline, and erythromycin. Antibiotics alleviate acne symptoms by reducing acne bacteria, inhibiting lipase activity, and reducing free fatty acid production. However, continuous use of antibiotics leads to antibiotic resistance. In addition, retinoids, isotretinoin, and retinol, which are vitamin A derivatives, are substances that can suppress hyperkeratinization of hair follicles and improve acne symptoms.

However, care should be taken when using isotretinoin as it is a teratogenic substance. In order to solve the above problems, a wide range of acne treatment substances are being searched for natural products known to have relatively few side effects compared to single substances. Examples of these include tea tree oil, green tea, and aloe. However, in the case of these plant extracts, the effective concentration of substances exhibiting efficacy is weak, and the situation does not show practical effects on acne symptoms triggered by various pathways.

On the other hand, mucin refers to all the viscous substances secreted from the exocrine glands of animals, and is a complex protein combined with carbohydrates. Mucin promotes the digestion of protein, which is the main component of cells, and has a useful effect in the body, and also acts to lower cholesterol, protect the stomach wall, and detoxify. Generally, people think of mucin as a substance that protects the gastric wall, but mucin has antibacterial properties. Plant mucus is a high-viscosity polymeric substance (polymer polysaccharide or glycoprotein) present in all plants, including some microorganisms, and is also called vegetable mucin or mucilage. In plant ecology, slime plays various roles such as transporting and preserving water in the plant body, storing and transporting electrolytes and low molecular weight substances, germination of seeds, and protecting wounds. In addition, plants contain not only electrolytes but also dissolved secondary metabolites of small molecules along with plant mucins. Plant mucin is more special in that it does not contain artificial chemical ingredients and is a naturally obtained ingredient.

Under this background, among plant-derived mucins or plant extracts containing mucin, we have tried to develop an effective treatment composition for acne caused by various pathways by selecting substances that exhibit an inhibitory effect on the growth of acne bacteria and an inhibitory effect on inflammation caused by acne bacteria, As a result, the work aspect was completed.

One aspect is to provide a cosmetic composition for improving skin conditions comprising a plant extract containing a vegetable mucin or mucin.

Another aspect is to provide a pharmaceutical composition for preventing or treating skin diseases comprising a vegetable mucin or a plant extract containing mucin as an active ingredient.

One aspect provides a cosmetic composition for improving skin conditions containing vegetable mucin or a plant extract containing mucin.

In this specification, the term "cosmetic composition" refers to an article used on the human body to clean and beautify the human body to add attractiveness, brighten the appearance, or maintain or promote skin health.

When used as a cosmetic composition, components commonly used in extracts containing mucin or mucin as an active ingredient may be included. These ingredients are conventional adjuvants and/or carriers, such as, for example, antioxidants, stabilizers, solubilizers, vitamins, pigments and flavors. In addition, the cosmetic composition may further include a skin absorption promoting material in order to enhance sebum reduction and acne treatment, prevention and improvement effects.

The mucin used in the composition may be obtained from Pachyrhizus erosus , lotus ( Nelumbo nucifera ), marshmallow ( Althaea Officinalis ), plantain ( Plantago asiatica ) and tamarind ( Tarindus indica ) seeds.

The vegetable mucin is one or more, two or more, three or more or four or more mucins selected from the group consisting of yambean root-derived mucin, lotus root-derived mucin, marshmallow root-derived mucin, plantain seed-derived mucin, and tamarind seed-derived mucin, or the mucin It may be a plant extract containing

For example, the vegetable mucin is a combination of yam bean root-derived mucin and lotus root-derived mucin, marshmallow root-derived mucin, plantain seed-derived mucin and tamarind seed-derived mucin combination, yam bean root-derived mucin and tamarind seed-derived mucin. Combinations may be included.

In one embodiment, the plant extract containing the vegetable mucin or mucin is yambin root derived mucin, lotus root derived mucin, marshmallow root derived mucin, plantain seed derived mucin and tamarind seed derived mucin; Alternatively, a plant extract containing the mucin may be included.

In the present specification, among several natural substances having antibacterial activity in order to find a substance effective for improving the skin condition of acne skin, it exhibits excellent antibacterial activity against acne-causing bacteria and at the same time suppresses the inflammatory reaction that expands acne symptoms. Plant mucin effective A study was conducted to find a combination of

As a result, when mucin derived from Yambin root ( Pachyrhizus erosus ), lotus flower ( Nelumbo nucifera ) root, marshmallow ( Althaea Officinalis ) root, plantain ( Plantago asiatica ) seed, and tamarind ( Tarindus indica ) seed was combined, antibacterial activity against acne-causing bacteria It was found that the effect and anti-inflammatory effect increased dramatically, and it was confirmed that there was no problem with safety even when applied to the skin.

The combination of the extracts is 80 to 100 parts by weight of yambin root-derived mucin, 20 to 100 parts by weight, 40 to 100 parts by weight, 40 to 60 parts by weight, 60 to 100 parts by weight, or 80 to 100 parts by weight of lotus root-derived mucin, 80 to 100 parts by weight of marshmallow root-derived mucin, 80 to 100 parts by weight of plantain seed-derived mucin, and 80 to 100 parts by weight of tamarind seed-derived mucin.

Yam bean ( Pachyrhizus erosus ) is a legume, also called jicama or Mexican potato, a climbing bulb. Stems and fruits contain rotenone, a toxic substance, so only the bulbs (roots) are edible, high in moisture (90%) and low in carbohydrates and calories. It is rich in fiber, vitamin C, and mucin, and contains inulin, which is effective in controlling sugar levels, preventing diabetes, and losing weight, and was selected as one of the 'World's Top 20 Health Foods' by The Huffington Post of the United States. In Korea, it is used in salads, raw meat, dongchimi, and water kimchi.

Lotus ( Nelumbo nucifera ) is a perennial aquatic plant belonging to the water lily family, native to India and China, and widely distributed in Korea and Japan. In addition, in terms of use, flowers are used for ornamental purposes and tea preparations, and leaves, roots, and fruits have been eaten. Lotus root (蓮 根) is formed by the tuber of the lotus enlarged into the ground. It is rich in dietary fiber to promote intestinal activity, and contains mucin, a glycoprotein, which lowers blood pressure and cholesterol levels in the body. It is reported that tannin contained in lotus root is effective for various hemorrhages, and is effective for mental stability, fatigue recovery, nicotine detoxification, and prevention of heart disease.

Marshmallow ( Althaea Officinalis ) is derived from the Greek word 'altho' (to treat), which is derived from the medicinal properties of plants, and the species name also means medicinal herbs. In the English name, 'marsh' refers to a state that grows well in wetlands, and 'mal-low' refers to mallow. This herb is a perennial plant that grows 1.5m tall, has strong cold resistance, and its leaves and stems are covered with soft downy hairs like velvet. Leaves are rather thick, heart-shaped, large and shallowly divided. Flowers bloom in July-August in pink 5-pieces of 2.5 cm in size, 4-5 at the bottom of the leaf at the end of the stem. Marshmallow, which produces round and flat fruits, has a particularly fragrant and light scent throughout the plant and contains 25-30% of mucus. It is one of the precious plants that have been used as medicinal herbs since ancient times, and the ancient Arabs also used the leaves as a liniment as an anti-inflammatory because of its excellent medicinal properties. In addition, the leaves and roots were used as a salad and enjoyed the sticky and sweet taste.

Plantago asiatica is a perennial herb belonging to the Plantaginaceae family, and its young leaves are edible. In oriental medicine, it is called chajeoncho (車前草) by pulling out the roots and drying them, and the seeds are used as a medicinal material called psyllium, and are distributed in Korea, Japan, Sakhalin, Taiwan, China, Siberia, the Eastern Himalayas, Java, Malaysia, etc. . Psyllium hull is a plantain seed husk that contains a large amount of mucus-forming ingredients and is a food with excellent water retention. In addition to a large amount of mucilage, there are lipids, aucubin, galacta, polysaccharide, and succinic acid.

Tamarind ( Tarindus indica ) is an evergreen tree native to North Africa and has been cultivated in India for centuries. It was brought to Mexico by Spanish conquistadors in the 17th century and is now cultivated in tropical regions around the world, including the Caribbean, Southeast Asia, and China. Polysaccharides extracted from tamarind seeds are biocompatible, non-carcinogenic, and stable against heat and pH, with little stringiness and low stickiness, so they are used as thickeners and stabilizers in foods and as various pharmaceutical excipients in pharmaceuticals. In cosmetics, it is used as an applicability improver.

When the mucin is extracted from plants, it is preferable to use water, alcohol having 1 to 5 carbon atoms, hexane, chloroform, butylene glycol, or a mixed solvent extracted or purified as an extraction and process solvent. , but is not necessarily limited thereto.

In addition, the mucin can be obtained through a conventional purification process in addition to extraction and purification using the solvent. Through various additional purification methods, such as, for example, separation using ultrafiltration membranes with a certain molecular weight cut-off value, separation by various chromatography (designed for separation according to cree, charge, hydrophobicity or affinity). Mucin can also be obtained through the obtained fraction.

In the present specification, mucin complexes derived from yam bean root, lotus root, marshmallow root, plantain seed, and tamarind seed were prepared and configured at various weight ratios to test antibacterial and anti-inflammatory effects.

In one embodiment, the composition may inhibit NO (nitric oxide) production or TNF-α expression.

In the present specification, the skin acne bacteria are, for example , Candida albicans, Propionibacterium acnes, Staphylococcus aureus and Cutibacterium acnes. It may be one or more selected from the group consisting of

In another specific embodiment, it was confirmed that the mucin or the composition containing the mucin of one aspect has antibacterial activity or antioxidant activity against Cutibacterium acnes .

Therefore, one aspect of the vegetable mucin or an extract containing mucin can be usefully used for improving acne-prone skin, which is the object of one aspect.

The composition may contain vegetable mucin or an extract containing mucin as an active ingredient in an amount of 0.001 to 10% by weight, preferably 0.01 to 10% by weight, more preferably 0.1 to 10% by weight based on the total weight of the composition. . If the content is less than 0.001%, the anti-inflammatory and acne-reducing effect is too weak, and if it exceeds 15% by weight, the increase in the effect due to the increase in the content is insufficient and the stability of the formulation is not secured.

The cosmetic composition may be prepared in any formulation conventionally prepared in the art. Such formulations are formulated into, for example, solutions, suspensions, emulsions, pastes, gels, creams, lotions, powders, soaps, surfactant-containing cleansers, oils, powder foundations, emulsion foundations, wax foundations and sprays, and the like. It may be, but is not limited thereto. More specifically, lotion, toner, skin softener, skin toner, astringent, lotion, milk lotion, moisture lotion, nutrient lotion, massage cream, nutrient cream, moisture cream, hand cream, hand sanitizer, foundation, essence, nutrient essence, It can be prepared as one formulation selected from the group consisting of packs, soaps, cleansing foams, cleansing lotions, cleansing creams, body lotions, body cleansers, suspensions, gels, powders, pastes, mask packs, and sheets.

Another aspect provides a pharmaceutical composition for preventing or treating skin diseases comprising a vegetable mucin or a plant extract containing mucin as an active ingredient.

The plant mucin or plant extract containing the mucin is as described above.

The skin disease may be a disease caused by skin inflammation, and may include, for example, dermatitis, atopic dermatitis, allergic dermatitis, seborrheic dermatitis, psoriasis, and acne, but is not limited thereto.

The term "prevention" includes inhibiting the development of a disease.

The term "treatment" includes the inhibition, alleviation or elimination of the development of a disease.

The pharmaceutical composition may be prepared by further including one or more pharmaceutically acceptable carriers. A pharmaceutically acceptable carrier may be a mixture of saline, sterile water, Ringer's solution, buffered saline, dextrose solution, maltodextrin solution, glycerol, ethanol, and one or more of these components, and, if necessary, antioxidants and buffers. , bacteriostatic agents and other conventional additives may be added.

In addition, diluents, dispersants, surfactants, binders, and lubricants may be additionally added to prepare formulations for injection such as aqueous solutions, suspensions, and emulsions, pills, capsules, granules, or tablets. Furthermore, it can be preferably formulated according to each disease or component by an appropriate method in the art.

The pharmaceutical composition may contain at least one known active ingredient having an anti-inflammatory effect together with a vegetable mucin or a plant extract containing mucin.

The pharmaceutical composition may be administered orally or parenterally (for example, intravenously, subcutaneously, intraperitoneally or topically applied) according to the desired method, and the dosage is determined according to the patient's weight, age, sex, and health condition. , the range varies depending on the diet, administration time, administration method, excretion rate, and severity of the disease. The daily dose of the composition is about 0.0001 to 500 mg/kg, preferably about 0.001 to 300 mg/kg, and it is preferable to divide the administration once or several times a day.

Plant mucins or extracts containing plant mucins according to one aspect have antibacterial effects against acne bacteria, NO production, and inhibitory activity of TNF-α expression, which is an inflammatory mediator, so that they are useful in cosmetic compositions or pharmaceutical compositions for improving skin conditions There is an effect that can be.

According to one aspect, the cosmetic composition has an excellent effect of inhibiting the growth of acne bacteria, Propionibacterium acnes .

The cosmetic composition containing the extract prepared according to one aspect as an active ingredient may be prepared in any formulation commonly prepared in the art, such as lotion, lotion, cream and essence.

Hereinafter, it will be described in more detail through Examples, Comparative Examples and Experimental Examples. This is to explain the invention in detail to the extent that a person skilled in the art can easily inspect the invention, but does not mean that the technical spirit and scope of the aspect are limited.

Preparation Example 1: Preparation of vegetable mucin

After pulverizing 100 g of the dried yam bean root, it was heated and extracted with 3 L of 10% EtOH for 12 hours, cooled, and filtered through a filter paper having a 1 μm permeation size to obtain a filtrate. The obtained filtrate was concentrated under reduced pressure to obtain a 10-fold concentrated solution. Three times the amount of EtOH is added to the concentrated solution and sedimentation is performed at room temperature. Plant-derived mucin was prepared by recovering only the precipitated portion through centrifugation or filtration, followed by hot air drying, vacuum drying, or freeze drying.

Dry powders of lotus root, marshmallow root, plantain seed, and tamarind seed were prepared in the same manner as above.

Compositions of Examples and Comparative Examples: Preparation of mucin complexes derived from yambin root, lotus root, marshmallow root, plantain seed and tamarind seed

A mixture containing mucin derived from yam bean root, lotus root, marshmallow root, plantain seed and tamarind seed was prepared according to the compositions shown in Tables 1 and 2 below. Specifically, each composite was mixed with the composition shown in Tables 1 and 2 below, and the composite was transferred to a sterilized container (KRS A-1, Health up, Korea) and stored in a refrigerator at 5°C.

division weight ratio Yambin Root Mucin lotus root mucin Marshmallow Root Mucin plantain seed mucin Tamarind Seed Mucin Example 1 One One One One One Comparative Example 1 One - - - - Comparative Example 2 - One - - - Comparative Example 3 - - One - - Comparative Example 4 - - - One - Comparative Example 5 - - - - One Comparative Example 6 One - One - - Comparative Example 7 One - One One - Comparative Example 8 One - One One One

division weight ratio Yambin Root Mucin lotus root mucin Marshmallow Root Mucin Plantain Seed Mucin Tamarind Seed Mucin Example 2-1 One 0.2 One One One Example 2-2 One 0.4 One One One Example 2-3 One 0.6 One One One Example 2-4 One 0.8 One One One

Experimental Example 1: Inhibition of NO production

In order to investigate the anti-inflammatory effect of mucins derived from yam bean root, lotus root, marshmallow root, plantain seed, and tamarind seed, the NO production inhibitory effect was confirmed. RAW 264.7 cells, which are mouse macrophages, were dispensed into a 60 mm plate at a density of 2 X 10 ⁶ cells/dish and cultured in the plate for 24 hours. In order to induce an inflammatory reaction, a new medium containing LPS (lipopolysaccharide) at a concentration of 1 μg/ml and a test substance was treated and cultured for 24 hours. Anti-inflammatory activity evaluation through NO assay was performed using griess A and B reagents, mixing 1% sulfanilamide and 0.1% N-(1-naphtyl)ethylenediamine dihydrochloride reagent in a 1:1 ratio. In this experimental example, all of Example 1, Examples 2-1 to 2-4, and Comparative Examples 1 to 8 were treated the same at a concentration of 500 ug/ml. After processing Example 1, Examples 2-1 to 2-4, and Comparative Examples 1 to 8 in a 96-well plate, the supernatant of the cultured medium for 24 hours at 37 ° C. 5% CO ₂ griess (A + B) After mixing 50 μl of each with the reagent at a 1:1 ratio and storing at room temperature for 10 minutes, the NO production inhibitory ability was measured by ELISA measurement at 540 nm. The results are shown in Tables 4 and 5 below. The NO production inhibition rate (%) refers to the value obtained by subtracting the NO production rate (%) from 100% based on the control group (100%).

division NO production inhibition rate (%) Example 1 48.2 Example 2-1 45.9 Example 2-2 65.1 Example 2-3 68.2 Example 2-4 55.3

division NO production inhibition rate (%) Comparative Example 1 18.6 Comparative Example 2 22.1 Comparative Example 3 13.6 Comparative Example 4 12.1 Comparative Example 5 16.0 Comparative Example 6 22.9 Comparative Example 7 30.1 Comparative Example 8 29.1

As shown in Table 4 and Table 5, the samples of Examples 2-1 to 2-4 were all significantly improved in NO production inhibition rate compared to Comparative Examples 1 to 8. Specifically, when the predicted value of Colby's equation is calculated based on the NO production inhibition rate of Comparative Example 2 and Comparative Example 8, 44.9% is obtained. It was confirmed that the synergistic effect appeared by showing the result exceeding. In particular, the samples of Examples 2-2 to 2-3 exhibited a remarkably high NO production inhibition rate.

Experimental Example 2: Confirmation of inhibitory effect on the expression of inflammatory cytokine TNF-α

In order to investigate the anti-inflammatory effect of mucins derived from yam bean root, lotus root, marshmallow root, plantain seed and tamarind seed, the inhibitory effect on the expression of the inflammatory cytokine TNF-α was confirmed. Mouse macrophage RAW 264.7 cells were adjusted to 5Х10 ⁵ cells/well using DMEM medium supplemented with 10% FBS, and then inoculated into a 12 well plate and cultured for 18 hours. In this experimental example, all of Example 1, Examples 2-1 to 2-4, and Comparative Examples 1 to 8 were treated the same at a concentration of 500 ug/ml. After culturing and maintaining a starvation state for 12 hours, LPS 10ng / mL and Example 1, Examples 2-1 to 2-4 and Comparative Examples 1 to 8 were treated and cultured for 24 hours. RNA was extracted from cultured cells and the expression rate of TNF-α was confirmed through reverse transcription polymerase chain reaction (RT-PCR). The TNF-α expression rate was calculated by Equation 1 below, and the TNF-α expression inhibition rate refers to a value obtained by subtracting the TNF-α expression rate from 100%. The results are shown in Tables 6 and 7 below.

[Equation 1]

TNF-α expression rate (%) = (sample TNF-α expression level/control group TNF-α expression level) Х100

division TNF-α expression inhibition rate (%) control group 0.0 Example 1 45.0 Example 2-1 51.2 Example 2-2 59.7 Example 2-3 59.9 Example 2-4 55.2

division TNF-α expression inhibition rate (%) Comparative Example 1 18 Comparative Example 2 20.1 Comparative Example 3 17.1 Comparative Example 4 5.7 Comparative Example 5 8.6 Comparative Example 6 31.7 Comparative Example 7 32.2 Comparative Example 8 39.3

As shown in Tables 6 and 7 above, the samples of Examples 2-1 to 2-4 showed significantly improved inhibition of TNF-α expression compared to Comparative Examples 1 to 8. Specifically, when calculating the predicted value of Colby's equation based on the TNF-α expression inhibition rate of Comparative Example 2 and Comparative Example 8, 51.5% is obtained, and the actual values of Examples 2-1 to 2-4 are all Colby's equation It was confirmed that the synergistic effect appeared as the result exceeded the predicted value. In particular, the samples of Examples 2-2 to 2-3 showed a remarkably high rate of inhibition of TNF-α expression.

Experimental Example 3: Cutibacterium acnes of the composite ( Cutibacterium acnes) Confirmation of antibacterial activity against

An experiment was performed to measure the Minimum Inhibition Concentration (MIC) of each sample. Specifically, Cutibacterium acnes cultured for 24 hours was placed in 3 ml RCM medium, and samples were added at each concentration at the same time, followed by incubation at 37° C. for 24 hours under anaerobic conditions. To measure the MIC of caffeic acid, a two-fold serial dilution method was used. Here, MIC is defined as the minimum concentration that inhibits the growth of microorganisms. The results are shown in Tables 8 and 9 below.

division Minimum inhibitory concentration (ppm) Example 1 1510 Example 2-1 1250 Example 2-2 650 Example 2-3 682 Example 2-4 980

division Minimum inhibitory concentration (ppm) Comparative Example 1 3620 Comparative Example 2 4250 Comparative Example 3 8250 Comparative Example 4 5230 Comparative Example 5 4520 Comparative Example 6 3290 Comparative Example 7 3370 Comparative Example 8 2910

As shown in Tables 8 and 9, it was confirmed that yambean root, lotus root, marshmallow root, plantain seed, and tamarind seed-derived mucin showed stronger antibacterial activity against acne strains when treated with the complex extract than a single composition. All of the samples of Examples 2-1 to 2-4 showed significantly improved antibacterial activity against P. acnes compared to Comparative Examples 1 to 8, and in particular, the samples of Examples 2-2 to 2-4 showed a marked improvement in antibacterial activity against C. acnes . The antibacterial activity was remarkably high.

As reviewed above, the specific embodiment of one aspect has been described in detail, but those skilled in the art who understand the idea of one aspect may add, change, or delete other components within the scope of the same idea, thereby degenerate other inventions or Other embodiments may readily be suggested that fall within the scope of an aspect idea. Therefore, the embodiments described above should be understood as illustrative in all respects and not limiting. The scope of one aspect is indicated by the scope of the following claims rather than the above-described detailed description, and all changes or modifications derived from the meaning and scope of the claims and equivalent concepts thereof are included in the scope of one aspect. should be interpreted as

Claims (10)

A cosmetic composition for improving skin conditions comprising the following i) or ii) components;
i) mucin derived from yambean root, mucin derived from lotus root, mucin derived from marshmallow root, mucin derived from plantain seed, and mucin derived from tamarind seed; and
ii) Yambin root extract, lotus root extract, marshmallow root extract, plantain seed extract and tamarind seed extract each containing mucin. delete The cosmetic composition of claim 1, wherein the cosmetic composition comprises 80 to 100 parts by weight of mucin derived from yambean root, 20 to 100 parts by weight of mucin derived from lotus root, 80 to 100 parts by weight of mucin derived from marshmallow root, 80 to 100 parts by weight of mucin derived from plantain seed, and A cosmetic composition for improving skin condition comprising 80 to 100 parts by weight of tamarind seed-derived mucin. The cosmetic composition for improving skin condition according to claim 3, which is contained in 40 to 60 parts by weight of the lotus root-derived mucin. The cosmetic composition according to claim 1, wherein the skin condition improvement is for prevention or improvement of skin inflammation or acne, or antibacterial use. The method according to claim 5, wherein the antibacterial is Candida albicans ( Candida albicans ) , Propionibacterium acnes ( Propionibacterium acnes ), Staphylococcus aureus ( Staphylococcus aureus ) , Cutibacterium acnes ( Cutibacterium acnes ) from the group consisting of A cosmetic composition for improving skin condition having antibacterial activity against at least one selected species The cosmetic composition for improving skin condition according to claim 1, wherein the extract is extracted or purified with water, alcohol having 1 to 5 carbon atoms, hexane, chloroform, butylene glycol, or a mixture thereof. The cosmetic composition for improving skin condition according to claim 1, wherein the composition inhibits NO (nitric oxide) production or TNF-α expression A pharmaceutical composition for the prevention or treatment of inflammatory skin diseases, acne, or skin infections caused by P. acnes, comprising the following i) or ii);
i) mucin derived from yambean root, mucin derived from lotus root, mucin derived from marshmallow root, mucin derived from plantain seed, and mucin derived from tamarind seed; and
ii) Yambin root extract, lotus root extract, marshmallow root extract, plantain seed extract and tamarind seed extract each containing mucin.
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