KR102533237B1 - Cosmetic composition containing complex medicinal herbs extract for improving condition of hair and preventing hair loss - Google Patents

Abstract

The present invention relates to a cosmetic composition for preventing hair loss or improving the scalp containing a herbal complex extract as an active ingredient, and more particularly, for a cosmetic composition having an effect of preventing hair loss or improving the scalp, , Mortice bark, Houttuynia cordata, and herbal raw materials consisting of ginseng, respectively, are separately mixed with an extraction solvent, heated, and aged; Illite is mixed with an extraction solvent, heated, stirred, matured, and precipitated; Each of the heated and aged raw materials is filtered and centrifuged several times to prepare each herbal raw material extract, and the centrifuged herbal raw material extract is mixed to contain the herbal composite extract as an active ingredient Hair loss, characterized in that It may include a cosmetic composition having a preventive or scalp improving effect.
The cosmetic composition according to the present invention contains, as active ingredients, herbal complex extracts of Arborvitae extract, Angelica extract, leaf extract, peppermint extract, moth extract, houttuynia cordata extract, ginseng extract, and illite extract, and has little skin irritation and stability even when used for a long time. It has an excellent hair loss prevention or scalp improvement effect.

Description

COSMETIC COMPOSITION CONTAINING COMPLEX MEDICINAL HERBS EXTRACT FOR IMPROVING CONDITION OF HAIR AND PREVENTING HAIR LOSS}

The present invention relates to a cosmetic composition for preventing hair loss or improving the scalp containing a herbal complex extract as an active ingredient, and more particularly, for a cosmetic composition having an effect of preventing hair loss or improving the scalp, , Mortice bark, Houttuynia cordata, and herbal raw materials consisting of coriander, each mixed with an extraction solvent, filtered and centrifuged several times, and mixed with the extract, characterized in that it contains an herbal composite extract as an active ingredient, which has an effect of preventing hair loss or improving the scalp It relates to a cosmetic composition.

As society becomes more complex and civilization develops, the population of hair loss due to mental and physical stress, environmental pollution, etc. due to internal and external factors such as urban industrialization and genetic factors is gradually increasing. and the consequent social and economic problems are becoming serious.

Hair loss refers to a condition in which hair is not present or poor in the area where hair should be, and is a progressive disease caused by insufficient nutrition supply and metabolism necessary for hair generation. In general, if more than 100 hairs fall out per day, it is called alopecia. It depends on age, season, health condition, scalp and hair condition, nutritional condition, and level of sleep. It is caused by a variety of causes, such as hair growth.

Alopecia is a disease in which hair is lost in areas where it normally exists, and it mainly occurs on the head. It is characterized by the local hair of the frontal and parietal regions of the scalp turning into vellus hair, gradually shortening and thinning, and miniaturizing the hair follicles.

For conventional hair loss treatment, topical application agents and oral therapeutic agents are prescribed. However, these treatments have been reported to have side effects, and as the need for management for healthy hair and scalp emerges, the need for research on natural hair loss treatments with low risk of side effects is emerging.

As interest in natural products increases, many efforts are being made to search for functional substances from natural products, and methods for using extracts such as wood, leaves, and minerals of trees with excellent physiological activity as functional substances are actively researched. . There are many reasons why natural extracts are in the limelight, but the biggest reason is that there is little risk of side effects and reduced tolerance that can occur when chemical products are used for a long time.

Biochemical and pharmacological studies on hair loss and hair growth have been conducted for a long time, and various medicinal materials and herbal extracts for hair loss prevention, hair growth effect, and hair growth promotion have been developed. cnidium, baekji, dangjak, gamguk, burdock root, ginko leaf, baekjain, yangha, raw pine leaves, elvan, charcoal, ocher, mokdan, red ginseng, rice bran, ginseng, wild chrysanthemum, gosam, black bean, black sesame, wolfberry, Ogapi, green tea, mungji, manbyeongcho, silkworm, dansam, rich, ginger, tangerine peel, orange peel, lemon peel, aloe, nasturtium, seokjangpo, black sesame, garlic, etc. However, in the case of natural products, it is difficult to use formulations due to low self-stability, and the development of safer and easier-to-use materials derived from natural products is required.

Korean Patent Registration No. 10-1661245 Korean Patent Registration No. 10-2041995

The present invention is to solve the above problems, and to provide a cosmetic containing a natural product-derived antioxidant material that is safe and easy to use. In addition, the present invention is a cosmetic composition for preventing hair loss or improving the scalp, comprising herbal complex extracts of oriental plants such as Arborvitae extract, angelica extract, leaf extract, peppermint extract, moth extract, houttuynia cordata extract, ginseng extract, and illite extract as active ingredients. Its purpose is to provide

In order to achieve the above object, the present invention, for a cosmetic composition having an effect of preventing hair loss or improving the scalp, separately mixes oriental herbal ingredients consisting of arborvitae, angelica, leaflet, peppermint, moth, eoseongcho, and gosam in an extraction solvent. heating and aging; Illite is mixed with an extraction solvent, heated, stirred, matured, and precipitated; Each of the raw materials mixed with the solvent and heated and aged is filtered and centrifuged several times to prepare each raw material solvent extract, and the raw material solvent extract is extracted by generating water vapor in a vacuum distillation extractor, and then cooled and condensed to reduce each raw material. A cosmetic composition having an effect of preventing hair loss or improving the scalp, characterized in that it contains as an active ingredient an herbal composite extract prepared by mixing each of the herbal raw material extracts prepared by preparing a distillation extract in the same volume ratio. it could be

The herbal composite extract and the herbal composite extract are characterized in that they contain 0.05 to 80.0% (w/w) based on the total weight of the cosmetic composition.

The cosmetic composition is formulated into topical preparations such as ointments, lotions, sprays, etc., and softening lotion, converging lotion, nutrient lotion, scalp agent, essence, scrub agent, powder, shampoo, rinse, serum, It is composed of a formulation selected from the group consisting of mist, hair conditioner, hair lotion, liquid tonic form, soap, cream, and the like.

Cosmetic products containing the cosmetic composition according to the present invention are characterized in that they are selected from shampoo, hair essence, hair conditioner, hair mist, cream, lotion, hair skin, mask pack, and soap.

The cosmetic composition according to the present invention includes herbal complex extracts of Arborvitae extract, angelica extract, leaf extract, peppermint extract, moth extract, houttuynia cordata extract, sorghum extract, and illite extract, with little skin irritation even when used for a long time, stability, and hair loss It has the advantage of being able to provide prevention or scalp improvement effects.

1 is a view showing a manufacturing process of a herbal composite extract according to an embodiment of the present invention,
Figure 2 is a photograph showing the antibacterial activity of the cosmetic cream, which is a cosmetic product containing the herbal composite extract of the present invention as an active ingredient,
Figure 3 is a photograph showing the scalp improvement and hair loss improvement efficacy of cosmetic products containing the herbal composite extract of the present invention as an active ingredient,
Figure 4 is a photograph showing the scalp improvement and hair loss improvement efficacy of cosmetic products containing the herbal composite extract of the present invention as an active ingredient.

Hereinafter, preferred embodiments of the present invention will be described in more detail using drawings. However, the embodiments according to the present invention can be modified in many different forms, and the scope of the present invention should not be construed as being limited to the following examples. Embodiments of the present invention are provided to more completely explain the present invention to those skilled in the art.

The present invention was made to achieve the above technical problem, and the cosmetic composition according to the present invention is prepared by the first solvent extraction step and the second reduced pressure distillation extraction step, Step 1-1 of heating and aging herbal raw materials composed of Mortice bark, Eoseongcho, and Gosam by separately mixing 30% ethanol and distilled water in an extraction solvent mixed with 1:1 volume ratio;

1-2 steps of mixing 20 parts by weight of illite with 100 parts by weight of an extraction solvent, stirring, aging, and precipitating by heating;

The first filtration of each of the oriental raw materials according to steps 1-1 and 1-2 to obtain a liquid extract, and the liquid extract is first filtered and then centrifuged to prepare each raw material solvent extract. A first solvent extraction step comprising;

A third step of extracting each of the raw material solvent extracts from the first solvent extraction step by heating them in a vacuum distillation extractor at a pressure of 100 to 200 bar and a temperature of 40 to 60 ° C for 0.5 to 5 hours to generate steam; and

A fourth step of preparing each raw material vacuum distillation extract by cooling and condensing the water vapor at -5 to -10 ° C; A second vacuum distillation extraction step comprising a;

It contains as an active ingredient an herbal composite extract prepared by mixing each of the oriental raw material extracts prepared including 1: 1: 1: 1: 1: 1: 1 in a volume ratio.

1 is a view showing the manufacturing process of the herbal composite extract according to an embodiment of the present invention, Figure 2 is a photograph showing the antibacterial activity of a cosmetic product containing the herbal composite extract of the present invention as an active ingredient, 3 and 4 are photographs showing the scalp improvement and hair loss improvement efficacy of cosmetic products containing the herbal composite extract of the present invention as an active ingredient.

Arborvitae tree (Thujaorientalis L.) is an evergreen coniferous tree belonging to the Cupressaceae family. has been used Arborvitae leaves are best harvested in the fall. Arborvitae leaves contain a substance called hinokitiol, and this substance has been reported to exhibit strong bactericidal activity. In addition, 0.6-1% of essential oil is contained in the leaves of Arborvitae, and those contained in it are thujene, thujone, fenchone, pinene, and caryophyllene. Flavonoids include aromadendrin, quercetin, myricetin, hinokiflavone, and amenthoflavone. In addition, it contains tannin, resin, and vitamin C.

Arborvitae contains ingredients that act on the hair follicle epithelium and peripheral blood vessels to activate hair cells to promote hair production and improve the scalp. In addition, it has the function of normalizing the hair cycle by promoting the growth of hair follicle cells (hair papilla cells), anti-androgen action, and inhibition of 5a-reductase enzyme function. It has the effect of effectively suppressing nitric oxide and inflammatory cytokines, which are very important mediators for the reaction.

In the present invention, the cypress tree extract is firstly extracted by solvent extraction, and then the solvent extract is extracted and cooled by generating water vapor in a vacuum distillation extractor to extract the cypress leaf vacuum distillation extract. In general, as the temperature increases, the vapor pressure of a liquid increases. The temperature at which the vapor pressure of a liquid is equal to the external pressure is called the boiling point, and the boiling point when the external pressure is 1 atm is called the normal boiling point. General distillation is a method of separating a liquid by heating it to this normal boiling point. When the pressure is lowered using a vacuum pump or the like, the liquid starts to boil at a temperature lower than the normal boiling point, so the component materials can be separated at a low temperature using this. Technically, it works at a low temperature and the time it stays in the distillation column is shortened, so it suppresses product decomposition or unnecessary polymer production. Therefore, it is an appropriate method for distilling organic compounds that are easy to decompose or materials that are inconvenient to distill at atmospheric pressure due to their high boiling point. As a solvent extraction method, 20 to 50 parts by weight of washed cypress leaves are prepared, 2 to 5 times (w/w) of the extraction solvent is added, heated in a shaking incubator at 40 ° C to 90 ° C for 1 to 4 hours, and 1 to 4 fermented for a day. When the temperature is heated to less than 40 ° C, it is difficult to extract the active ingredient, and when heated to more than 90 ° C, the active ingredient of the herbal material may be destroyed. The aged raw material was filtered first with a 600 mesh filter to remove the residue, then with a 300 mesh filter, then with a 200 mesh filter, and the extract was separated. The sludge-free extract was centrifuged using a centrifuge at 4000 rpm for 30 minutes. The above centrifuged extract was filtered using a 500 mesh filter, and then centrifuged again at 8000 rpm for 30 minutes to prepare a myrrh solvent extract. As such, by repeating the filtration and centrifugation steps several times, purification and separation can be performed with high purity suitable for cosmetics.

In a state where a cooling condenser is installed to prevent the active ingredient from evaporating, the extract of the cypress tree solvent is extracted by generating water vapor while heating at a pressure of 100 to 200 bar and 40 ℃ to 60 ℃ for 0.5 to 10 hours, condensing the water vapor extract When the heating temperature is less than 40 ° C., the amount of water vapor obtained is insufficient because the pressure is not reduced, and when heated above 60 ° C., the active ingredient is destroyed. The cooling efficiency is set to be -5 ~ -10 ℃, and it is preferable that the bath temperature be 40 ℃ ~ 60 ℃ for smooth distillation. Through the vacuum distillation extraction step, an herbal arborvitae extract is prepared.

Angelica gigas Nakai is the root of Angelica gigas Nakai belonging to the Umbelliferae family. Meanwhile, Angelica acutiloba Kitagawa and Chinese Angelica (Angelica sinenis (Oliv.) Diels) are also distributed together. The main components are coumarin, an essential oil and fat-soluble substance, and polysaccharide, a water-soluble substance. Coumarin contains decursin, decursinol anglate, umbelliferone, nodakenin, and feuse It includes peucedanone, marmesin, dimethylsuberosin, isoimperatorin, etc. As a derivative, decursinol is isolated as the main component of Angelica gigas and is an active ingredient. Silver is decrusin and decrusinol angelate, which are structurally different isomers. Flavonoids include nonane, α-pinene, campheny, 2-methyloctane, lomatin, 2-furanmethanol, seselin, and guaiacol. , butyrolactone, etc. Angelica gigas has anticancer activity, anticancer activity, activating blood circulation and metabolism, and antioxidative activity as well as active oxygen removal effect.

At a concentration of 49.89 mg/L of Angelica quail extract, 50% inhibitory effect was observed. This was found to be at a similar level (49.52 mg/L) to the IC50 value of arbutin, which is widely used as a whitening raw material, and Angelica gigas extract directly reduces the activity of tyrosinase, which plays an important role in the early stage of melanin synthesis, thereby reducing melanin synthesis. It was confirmed that it can. In addition, it was confirmed that the melanin content decreased as the concentration of the extract increased, and the melanin released to the outside of the cell significantly decreased. In particular, at a concentration of 0.5 mg/L or more, the amount of melanin released to the outside of the cells was reduced by more than 1/3 compared to the treatment at a concentration of 0.1 mg/L.

Angelica is a solvent extraction method, first prepare 20 to 50 parts by weight of washed angelica, add 2 to 5 times (w / w) of extraction solvent, heat in a shaking incubator at 40 ℃ to 90 ℃ for 1 to 4 hours, and Fermented for ~4 days. The aged raw material was filtered first with a 600 mesh filter to remove the residue, then with a 300 mesh filter, then with a 200 mesh filter, and the extract was separated. The sludge-free extract was centrifuged using a centrifuge at 4000 rpm for 30 minutes. The above centrifuged extract was filtered using a 500 mesh filter, and then centrifuged again at 8000 rpm for 30 minutes to extract Angelica gigas extract. As such, by repeating the filtration and centrifugation steps several times, purification and separation can be performed with high purity suitable for cosmetics.

The Angelica gigas solvent extract is extracted by generating water vapor while heating at 100 to 200 bar air pressure and 40 ℃ to 60 ℃ for 0.5 to 10 hours in a state in which a cooling condenser is installed to prevent evaporation of active ingredients, and extraction is performed by condensing the water vapor. do. The cooling efficiency is set to be -5 ~ -10 ℃, and it is preferable that the bath temperature be 40 ℃ ~ 60 ℃ for smooth distillation. Through the vacuum distillation extraction step, an oriental Angelica gigas extract is prepared.

The angelica extract of the present invention may be prepared in a powder state by an additional process such as distillation under reduced pressure and freeze drying or spray drying.

Perilla frutescens seeds are dried perillae semen, and stems excluding small branches are called perillae ramulus. Perilla frutescens Britton var. acuta Kuto is a herbaceous plant belonging to the Lamiaceae family and has a height of 30 to 60 cm. The country of origin is China, and in Korea, it is distributed nationwide and cultivated for food or medicine. Perilla has a purple color and has a unique flavor. The stem is angular and straight, and the leaves are round or wedge-shaped at the bottom and have sharp and serrated ends. Perilla is propagated by seeds, and the shape of leaves and stems is similar to that of perilla, but the leaves and stems are purple. Flowers bloom in racemes around August-September, have a light purple color, are harvested around October, and are used for herbal medicine and medicinal purposes after drying.

The main component of perilla leaves and seeds is perillaldehyde, which contains about 50%, so it has a sleep prolonging effect. In addition, perillaketon, elsholtzianketon, naginataketon, and isoegomaketon are contained. Perilla leaves and seeds have antipyretic, sweating, analgesic, soothing, and detoxifying effects, and are widely used for medicinal purposes in oriental medicine. In particular, the leaves contain cyclodextrin, essential oil, anthocyans, flavonoid, rosmarinic acid, stigmasterol, etc., and are used as spices, seasonings, tonics, food coloring and cosmetics, pigment raw materials, oral deodorants, and antidotes. It is known to inhibit damage to nerve cells by reactive oxygen species. There is antioxidant activity and anti-inflammatory activity of perilla. It is said that perilla is more effective than antihistamines in allergic rhinitis related to inflammation, and it is known that it is effective in anti-cancer activity, antibacterial activity, and phagocytosis increase in addition to anti-oxidation and inflammation. In studies related to immune function, perilla leaf juice adversely affects the number and quality of neutrophils and macrophages in the area of inflammation, increasing phagocytic capacity, activating the adhesion of vascular endothelial cells, and removing active oxygen in inflammatory skin diseases useful for the treatment of

Leaf extract in the present invention is an extract obtained from perilla leaves. The leaf extract of the present invention was extracted through the first solvent extraction step and the second vacuum distillation extraction step. As a solvent extraction method, 20 to 50 parts by weight of washed perilla leaves are prepared, 2 to 5 times (w / w) of the extraction solvent is added, heated in a shaking incubator at 40 ℃ to 90 ℃ for 1 to 4 hours, and 1 to Fermented for 4 days. The aged raw material was filtered first with a 600 mesh filter to remove the residue, then with a 300 mesh filter, then with a 200 mesh filter, and the extract was separated. The sludge-free extract was centrifuged using a centrifuge at 4000 rpm for 30 minutes. The above centrifuged extract was filtered using a 500 mesh filter, and then centrifuged again at 8000 rpm for 30 minutes to extract a leaf extract. As such, by repeating the filtration and centrifugation steps several times, purification and separation can be performed with high purity suitable for cosmetics.

The leaflet solvent extract was extracted by generating water vapor while heating the leaflet solvent extract at a pressure of 100 to 200 bar and 40 ℃ to 60 ℃ for 0.5 to 10 hours in a state in which a cooling condenser was installed to prevent evaporation of active ingredients, and the water vapor was condensed and extracted. do. The cooling efficiency is set to be -5 ~ -10 ℃, and it is preferable that the bath temperature be 40 ℃ ~ 60 ℃ for smooth distillation. Through the vacuum distillation extraction step, an herbal lily extract is prepared.

The leaf extract of the present invention includes not only extracts obtained by the aforementioned extraction method, but also extracts obtained by a supercritical extraction method using high temperature and reduced pressure by carbon dioxide, or an ultrasonic extraction method. Decompression by carbon dioxide and extraction by high-temperature supercritical extraction means supercritical fluid extraction. In general, supercritical fluid is a liquid or gas that a gas has when it reaches its critical point under high-temperature and high-pressure conditions. It has properties of, and has a polarity chemically similar to that of non-polar solvents. Due to these properties, supercritical fluids are used for extraction of fat-soluble substances. Carbon dioxide becomes a supercritical fluid with both liquid and gaseous properties as the pressure and temperature go through the process of reaching the critical point due to the operation of the supercritical fluid device, and as a result, the solubility in fat-soluble solutes increases. When supercritical carbon dioxide passes through an extraction vessel containing a certain amount of sample, the fat-soluble substances contained in the sample are extracted by supercritical carbon dioxide. After extracting the fat-soluble substance, if supercritical carbon dioxide containing a small amount of co-solvent is passed through the sample remaining in the extraction vessel again, components that were not extracted with only pure supercritical carbon dioxide can be extracted and extracted.

The supercritical fluid used in the supercritical extraction method of the present invention can effectively extract active ingredients by using supercritical carbon dioxide or a mixed fluid in which a co-solvent is additionally mixed with carbon dioxide. One or a mixture of two or more selected from the group consisting of chloroform, ethanol, methanol, water, ethyl acetate, hexane, and diethyl ether may be used as the co-solvent. Most of the extracted samples contain carbon dioxide, and since carbon dioxide is volatilized in the air at room temperature, the extract obtained by the above method can be used as a cosmetic composition, and the co-solvent can be removed with a vacuum evaporator.

As the extraction solvent that can be used in the ultrasonic extraction method, one or a mixture of two or more selected from the group consisting of chloroform, ethanol, methanol, water, ethyl acetate, hexane, and diethyl ether may be used. The extracted sample can be vacuum filtered to recover the filtrate, then removed with a vacuum evaporator, and the extract can be obtained through a conventional extract preparation method of freeze-drying.

In addition, the leaf extract of the present invention also includes an extract that has undergone a conventional purification process and/or fermentation process. For example, fractions obtained through various additional purification methods, such as separation using an ultrafiltration membrane having a certain molecular weight cut-off value and separation by various chromatography, are also interpreted to be included in the leaflet extract of the present invention. In addition, the fermented product obtained by fermenting for 1 to 7 days while maintaining pH 5 to 7 under a temperature condition of 20 to 40 ° C. with bacteria selected from the group consisting of yeast, lactic acid bacteria, Bacillus genus bacteria and mixtures thereof is also a leaf extract of the present invention included in

The leaf extract of the present invention also includes an extract obtained by using a poaching method. Poje is a pharmaceutical technology that changes the original properties of medicinal materials by processing them based on the theory of oriental medicine. It mainly refers to the process of steaming, boiling, roasting, roasting or heating, or a process in which these are mixed. The processing conditions are easily selected from 60-100℃, 30 minutes to 6 hours in case of boiling, 120-180℃, 10 minutes to 2 hours in case of steaming, and 80-100℃, 10 minutes to 2 hours in case of baking. In the present invention, leaflets were steamed and used after being dried, and an extract was prepared using this. It can be extracted using a cloth manufacturing method in which perilla leaves are steamed and dried, and then extracted by a solvent extraction method, as well as a supercritical extraction method by high temperature and reduced pressure by carbon dioxide, or an extraction method by ultrasonic extraction.

The lobular extract of the present invention can be prepared in a powder state by additional processes such as distillation under reduced pressure and freeze drying or spray drying.

Mint is a perennial plant belonging to the Lamiaceae family and grows wild in wetlands in Korea, China, and Siberia. Mint is used for fever, headache, and symptoms of lack of sweat due to cold, congestion, sore throat, tonsillitis, and skin itching. , liver disease, abdominal pain, diarrhea and vomiting, etc., and pharmacological actions include antipyretic, anti-inflammatory, promotion of bile secretion and suppression of gastrointestinal smooth muscle, increase of mucus secretion in the respiratory tract, stimulation of the central nervous system, and uterine contraction. However, compared to the various effects of peppermint, research conducted has reported antioxidant, anticancer, antiallergic, and antibacterial properties.

The peppermint extract of the present invention was extracted through a first solvent extraction step and a second vacuum distillation extraction step. As a solvent extraction method, 20 to 50 parts by weight of washed mint is prepared, 2 to 5 times (w/w) of the extraction solvent is added, heated in a shaking incubator at 40 ° C to 90 ° C for 1 to 4 hours, and 1 to 4 fermented for a day. The aged raw material was filtered first with a 600 mesh filter to remove the residue, then with a 300 mesh filter, then with a 200 mesh filter, and the extract was separated. The sludge-free extract was centrifuged using a centrifuge at 4000 rpm for 30 minutes. The above centrifuged extract was filtered using a 500 mesh filter, and then centrifuged again at 8000 rpm for 30 minutes to extract mint extract. As such, by repeating the filtration and centrifugation steps several times, purification and separation can be performed with high purity suitable for cosmetics.

The peppermint solvent extract was extracted by generating water vapor while heating the peppermint solvent extract at a pressure of 100 to 200 bar and 40 ℃ to 60 ℃ for 0.5 to 10 hours in a state in which a cooling condenser was installed to prevent evaporation of active ingredients, and extraction was performed by condensing the water vapor. do. The cooling efficiency is set to be -5 ~ -10 ℃, and it is preferable that the bath temperature be 40 ℃ ~ 60 ℃ for smooth distillation. A peppermint extract is prepared through the vacuum distillation extraction step.

Morus alba Linne refers to the root bark of the mulberry tree (Morus alba Linne) belonging to the mulberry tree (Moraceae). It is listed in the middle class under the name of Sanggeun Baekpi (桑根白皮) in Sinnonbonchogyeong. Component As a triterpenoid compound, it contains α-amyrin and β-amyrin, and as a steroid compound, β-sitostrol. contains. And cyclomorucin, which is a flavonoid compound having an isoprenoid side chain, and kuwanon A, B, C, G, H (kuwanon A, B, C, G, H) are contained as flavonoids. .

On the other hand, it is known that 1,4-dideoxy-1,4-imino-D-ribitol, one of the pyrrolidine alkaloids isolated from moth bark, has inhibitory activity against eukaryotic DNA polymerase. In particular, hydroxy-resveratrol (oxy-resveratrol) contained in moth extract has excellent whitening and antioxidant effects, so it has acne scar pigmentation and anti-inflammatory properties.

As a solvent extraction method, 20 to 50 parts by weight of the first washed moth bark is prepared, 2 to 5 times (w/w) of the extraction solvent is added, heated in a shaking incubator at 40 ° C to 90 ° C for 1 to 4 hours, and then maintained for 1 to 4 days. ripen The aged raw material was filtered first with a 600 mesh filter to remove the residue, then with a 300 mesh filter, then with a 200 mesh filter, and the extract was separated. The sludge-free extract was centrifuged using a centrifuge at 4000 rpm for 30 minutes. The above centrifuged extract was filtered using a 500 mesh filter, and then centrifuged again at 8000 rpm for 30 minutes to prepare an extract of Mortar. As such, by repeating the filtration and centrifugation steps several times, purification and separation can be performed with high purity suitable for cosmetics.

In a state in which a cooling condenser is installed to prevent the active ingredient from evaporating, the solvent extract of the Mortice bark is heated at a pressure of 100 to 200 bar and 40 ℃ to 60 ℃ for 0.5 to 10 hours to extract by generating water vapor, and extracted by condensing the water vapor. do. The cooling efficiency is set to be -5 ~ -10 ℃, and it is preferable that the bath temperature be 40 ℃ ~ 60 ℃ for smooth distillation. Through the vacuum distillation extraction step to prepare an extract of oriental parsley.

Mortar bark extract of the present invention can be prepared in a powder state by additional processes such as distillation under reduced pressure and freeze drying or spray drying.

Houttuyniae Herba is an outpost of Houttuynia cordata Thunb, a perennial plant belonging to Sauruacese, and is characterized by its fishy scent, sour taste and cold nature. Eoseongcho likes a warm and humid climate and grows in shady and moist soil or waterside. Although there are differences depending on the region, Eoseongcho usually sprouts around April, flowers in early summer, and the fruiting period is between October and November. Eoseongcho is collected in summer when the leaves are lush and there are many flowers, dried in the sun, and then cut and used for medicinal purposes. In Korea, it grows or is cultivated in the central region, and in China, it is distributed in each province south of the Yangtze River. It has been reported to have various pharmacological actions such as diuretic action, analgesic action, antibacterial action, and antiviral action. The main component of Eoseongcho contains quercitrin, which is reported to have physiological activities such as anti-cancer, anti-inflammatory, and antioxidant effects. %, ash content 13.0%, crude fiber 13.8%, the stem contains low crude protein and crude fat, but high fiber, and at the same time, it has a high content of essential amino acids and unsaturated fatty acids, so it has the effect of suppressing fat absorption of a high-fat diet. Eoseongcho is a relatively common medicinal plant, and is known to improve adult diseases, treat atopic dermatitis, inhibit infections against various disease bacteria, and protect liver cells and kidney cells.

As a solvent extraction method, 20 to 50 parts by weight of washed Eoseongcho are prepared, 2 to 5 times (w / w) of extraction solvent is added, and heated in a shaking incubator at 40 ° C to 90 ° C for 1 to 4 hours, followed by 1 to 4 fermented for a day. The aged raw material was filtered first with a 600 mesh filter to remove the residue, then with a 300 mesh filter, then with a 200 mesh filter, and the extract was separated. The sludge-free extract was centrifuged using a centrifuge at 4000 rpm for 30 minutes. The above centrifuged extract was filtered using a 500 mesh filter, and then centrifuged again at 8000 rpm for 30 minutes to extract the Eoseongcho extract. As such, by repeating the filtration and centrifugation steps several times, purification and separation can be performed with high purity suitable for cosmetics.

The Eoseongcho solvent extract was extracted by generating water vapor while heating at a pressure of 100 to 200 bar and 40 ℃ to 60 ℃ for 0.5 to 10 hours in a state in which a cooling condenser was installed to prevent evaporation of active ingredients, and extraction was performed by condensing the water vapor. do. The cooling efficiency is set to be -5 ~ -10 ℃, and it is preferable that the bath temperature be 40 ℃ ~ 60 ℃ for smooth distillation. Through the vacuum distillation extraction step, an herbal eoseongcho extract is prepared.

Eoseongcho extract of the present invention can be prepared in a powder state by additional processes such as distillation under reduced pressure and freeze drying or spray drying.

Sophora flavescens Aiton (Sophora flavescens Aiton) belonging to the legume family (Leguminosae). It has the effect of clearing heat and dampness and insecticidal diuresis. The main component is an alkyloid containing 1-2%. The main alkaloid is matrine, and it contains oxymatrine, stereoisomers of matrine, allomatrine, sophoramine, or sophocarpine, as well as methylcytisine and anagyrine, which have slightly different structures. Also, kushenol H, kusheno K, kurarinol, sopho-flavescenol, and kuraridine are contained as flavonoids. Other triterpene saponins include soyasapogenol B. In case of atopic dermatitis or contact dermatitis, itching of the skin appears as the main symptom. Antihistamines or anti-allergic drugs are used to reduce itching, but they are far from a fundamental treatment.

The hair growth stimulating action of sorghum ginseng extract has been confirmed in vivo and in vitro. Although the mechanism for controlling hair growth has not been clearly identified, it is known that various factors are involved. Kosam extract promotes hair growth, and this action is the result of inhibition of 5a-reductase and promotion of production of IGF-1 (insulin-like growth factor-1) and KGF (keratinocyte growth factor), which are one of the growth hormones. . On the other hand, it is known that among the compounds isolated from gosam, flavonoid compounds inhibit the activity of cGMP phosphodiesterase type 5 (PDE5). In particular, it has been reported that sophoflavescenol inhibits cGMP phosphodiesterase type 5 (PDE5) activity significantly.

As a solvent extraction method, 20 to 50 parts by weight of washed sorghum ginseng is prepared, 2 to 5 times (w/w) of the extraction solvent is added, heated in a shaking incubator at 40 ° C to 90 ° C for 1 to 4 hours, and 1 to 4 fermented for a day. The aged raw material was filtered first with a 600 mesh filter to remove the residue, then with a 300 mesh filter, then with a 200 mesh filter, and the extract was separated. The sludge-free extract was centrifuged using a centrifuge at 4000 rpm for 30 minutes. The above centrifuged extract was filtered using a 500mesh filter, and then centrifuged again at 8000rpm for 30 minutes to extract the sorghum ginseng extract. As such, by repeating the filtration and centrifugation steps several times, purification and separation can be performed with high purity suitable for cosmetics.

The sorghum ginseng solvent extract was extracted by generating water vapor while heating at a pressure of 100 to 200 bar and 40 ℃ to 60 ℃ for 0.5 to 10 hours in a state in which a cooling condenser was installed to prevent evaporation of active ingredients, and the water vapor was condensed and extracted. do. The cooling efficiency is set to be -5 ~ -10 ℃, and it is preferable that the bath temperature be 40 ℃ ~ 60 ℃ for smooth distillation. Through the vacuum distillation extraction step, an herbal sorghum extract is prepared.

The ginseng extract of the present invention may be prepared in a powder state by additional processes such as distillation under reduced pressure and freeze drying or spray drying.

20 parts by weight of illite is mixed with 100 parts by weight of an extraction solvent, heated in a shaking extractor at 90 to 120 ° C. for 1 to 2 hours, stirred and aged for 1 to 4 days, and extracted by precipitation. At this time, it is aged in a sealed state to prevent air from entering during the stirring process. After aging, it is filtered several times to remove residues. First, the extract was filtered through a 600mesh filter, filtered through 300mesh and 200mesh, and the residual sludge was removed, and the extract was first centrifuged under conditions of 4000rpm and 30 minutes using a centrifuge.

The first centrifuged extract is filtered using a 500 mesh filter, and then centrifuged again at 8000 rpm for 30 minutes to extract the illite solvent extract. As such, by repeating the filtration and centrifugation steps several times, purification and separation can be performed with high purity suitable for cosmetics.

The illite solvent extract is extracted by generating water vapor while heating the illite solvent extract at a pressure of 100 to 200 bar and 40 ℃ to 60 ℃ for 0.5 to 10 hours in a state in which a cooling condenser is installed to prevent evaporation of the active ingredient, and the water vapor is condensed extract The cooling efficiency is set to be -5 ~ -10 ℃, and it is preferable that the bath temperature be 40 ℃ ~ 60 ℃ for smooth distillation. An illite extract is prepared through the vacuum distillation extraction step.

Illite is a representative natural clay material and has the property of properly adsorbing heavy metals, radionuclides, harmful gases, etc. Pure illite is generally white, but it is brown when it contains a large amount of iron. In some cases, it is pale yellow. Illite is known to effectively remove oil or toxic substances from the skin, and clays act on the skin to remove toxins by cation exchange properties, absorb wastes by reacting with organic substances, reduce inflammation by antibacterial action, and reduce inflammation by cleansing action. It shows effects such as keratin whitening effect, antioxidant action, metabolism activity, smooth blood circulation, and moisture control.

illite Bulk density (g/ml) 0. 3～0. 8 Particle size (㎛) 1 to 15 importance 2. 7 pH 7. 0～9. 0 (neutral) Specific surface area (m²/g) 2 to 15 Oil absorption (ml/ 100g) 30～50

As shown in Table 1, illite has a bulk density of 0.3 to 0.8 g/ml, which is the volume occupied by 1 g of solid. 8 g / ㎖, particle size 3 ~ 15 ㎛, specific surface 3 ~ 15 m² / g, oil absorption is preferably 30 ~ 40㎖ / 100g.

Illite crystal has a 2:1 layer structure in which one layer of Al(O,OH) ₆ octahedral sheet is sandwiched between two layers of SiO ₄ tetrahedral sheets, and the crystal structure of illite is Since Si ⁴⁺ is substituted by Al ³⁺ , K ⁺ exists between the layers for charge balance. Illite crystals have a developed cleavage plane, which is negatively charged because oxygen (O) exists on this cleavage plane, and O ^- and (OH) ^- exist on the edge perpendicular to the cleavage plane, so there are positive and negative charges here. exists. O ^- and (OH) ^- on rhombohedral surfaces act as ligands in cation surface complexation. As such, the surface of illite particles is negatively charged, and this surface charge plays an important role in adsorption of positive ions.

Illite is known for its effects such as whitening, skin purification, antibacterial, deodorization, moisturizing, skin protection, cellulite decomposition, and cell activation. It is non-toxic to the skin and has a skin purification effect by adsorbing sebum and organic substances, and has a cellulite decomposition effect through a positive ion effect. It emits far-infrared rays that help cell activity, and has functions such as blocking ultraviolet rays and adsorbing and removing heavy metal wastes. Therefore, it is used as a raw material for functional cosmetics such as atopy and acne.

ingredient contain Efficacy and Effect SiO₂silicon oxide) O waste and sebum removal Al (aluminum) O Accelerates blood circulation and metabolism, removes wastes Fe₂O₃ (iron oxide) O collagen binding Ca (calcium) O detox, calm Na (sodium) O Osmotic pressure, water balance Magnesium (Mg) O Promotion of waste excretion, binding of collagen K (knife) O Osmotic pressure control, water balance, soothing effect S (sulfur) O anti-inflammatory, antibacterial Ti (titanium) O Whitening Pb (lead) X Preservatives (heavy metals) Cd (cadmium) X

Table 2 above shows the effect of the components of Illite on the skin. Illite can be processed and added in powder or granular form, and processed into fine powder of 1000 mesh or more to be used in cosmetics. It can be used as granular particles of 1000 mesh or more for the same purpose as a beauty pack.

The oriental cedar extract, angelica extract, leaf extract, peppermint extract, moth extract, houttuynia cordata extract, ginseng extract, and illite extract are mixed in a volume ratio of 1: 1: 1: 1: 1: 1: 1 to prepare a herbal composite extract .

The herbal composite extract contains 0.05 to 80.0% (w/w) based on the total weight of the cosmetic composition, and more preferably 0.1 to 20.0% by weight. At this time, when the total weight of the herbal composite extract is less than 0.05% by weight, the effect is difficult to appear, and when it exceeds 80.0% by weight, there is a problem of price increase and may affect the stabilization of the formulation.

On the other hand, the formulation of the cosmetic composition according to the present invention is characterized in that the particle size is 1,500 nm or less. As a formulation to increase the efficiency of a functional herbal complex extract with stability secured, it is desirable to set the emulsified particle size to 1,500 nm or less. can

Ingredients included in the cosmetic composition of the present invention are various ingredients that maintain the activity of biological components in addition to the herbal complex extract as active ingredients, such as preservatives, osmotic agents, pH adjusting agents, buffers, stabilizers, aluminum hydroxide, aluminum phosphate, interface Activators, liposomes, thickeners, etc., and ingredients commonly used in cosmetic compositions, such as antioxidants, stabilizers, solubilizers, vitamins, pigments and flavors, and conventional adjuvants such as carriers, etc. may be included, but are not limited thereto. don't

The cosmetic composition of the present invention can be prepared in any formulation conventionally prepared in the art, for example, a softening lotion that directly acts on the hair loss area by formulating a topical formulation such as an ointment, lotion, or spray , Convergence lotion, nutrient lotion, scalp agent, essence, scrub agent, powder, shampoo, rinse, serum, mist, hair conditioner, hair lotion, liquid tonic type, soap, cream, etc. , but is not limited thereto.

When the formulation of the present invention is a paste, cream or gel, animal fiber, vegetable fiber, wax, paraffin, starch, tracanth, cellulose derivative, polyethylene glycol, silicone, bentonite, silica, talc or zinc oxide may be used as a carrier component. can

When the formulation of the present invention is a powder or spray, lactose, talc, silica, aluminum hydroxide, calcium silicate or polyamide powder may be used as a carrier component, and in particular, in the case of a spray, additionally chlorofluorohydrocarbon, propane / May contain a propellant such as butane or dimethyl ether.

When the formulation of the present invention is a solution or emulsion, a solvent, solvating agent or emulsifying agent is used as a carrier component, and water, ethanol, isopropanol, ethyl carbonate, ethyl acetate, benzyl alcohol, benzyl benzoate, propylene glycol, 1, 3-butylglycol oil, glycerol aliphatic esters, polyethylene glycol or fatty acid esters of sorbitan.

When the formulation of the present invention is a suspension, as a carrier component, a liquid diluent such as water, ethanol or propylene glycol, an ethoxylated isostearyl alcohol, a suspending agent such as polyoxyethylene sorbitol ester and polyoxyethylene sorbitan ester, microcrystalline Cellulose, aluminum metahydroxide, bentonite, agar or tracanth and the like may be used.

When the formulation of the present invention is a surfactant-containing cleanser, as carrier components, aliphatic alcohol sulfate, aliphatic alcohol ether sulfate, sulfosuccinic acid monoester, isethionate, imidazolinium derivative, methyl taurate, sarcosinate, fatty acid amide Ether sulfates, alkylamidobetaines, fatty alcohols, fatty acid glycerides, fatty acid diethanolamides, vegetable oils, linolin derivatives, or ethoxylated glycerol fatty acid esters may be used.

More preferably, the cosmetic composition may be prepared as a cosmetic product containing the same, and may be one product selected from shampoo, hair essence, hair conditioner, hair mist, cream, lotion, hair skin, mask pack, and soap. there is.

In addition, the cosmetic composition is a fatty substance, an organic solvent, a solubilizing agent, a thickening agent and a gelling agent, a softening agent, an antioxidant, a suspending agent, a stabilizer, and a foaming agent in addition to the herbal composite extract of the present invention or an active ingredient containing the same. , fragrances, surfactants, water, ionic or nonionic emulsifiers, fillers, sequestering agents and chelating agents, preservatives, vitamins, blocking agents, wetting agents, essential oils, dyes, pigments, hydrophilic or lipophilic actives, lipid vesicles or adjuvants commonly used in the field of cosmetology, such as any other ingredient commonly used in cosmetics.

Hereinafter, the present invention will be described in more detail through examples. These examples are only for explaining the present invention in more detail, and it will be apparent to those skilled in the art that the scope of the present invention is not limited by these examples according to the gist of the present invention. .

Herbal raw materials composed of Arborvitae, Angelica, Lobular, Peppermint, Mortar, Houttuynia cordata, Gosam, each of Arborvitae, Angelica, Angelica, Lobules, Mint, Peppermint, Mortice, Eoseongcho, Gosam, and Illite extracts 1:1, respectively. : 1 : 1 : 1 : 1 : 1 (w/w) mixing to prepare an herbal composite extract.

Shampoo was prepared as a cosmetic product containing the herbal complex extract of Example 1 as an active ingredient.

[Comparative Example 1]

In contrast to Example 2, a shampoo was prepared as a cosmetic product containing, as an active ingredient, the herbal extracts other than Illite from the herbal composite extract of Example 1.

[Experimental Example 1]

The moisture content of the cosmetic composition containing the herbal composite extract of Example 1 as an active ingredient was measured and shown in Tables 3 and 4.

(Mean±SD) visit illite 0 weeks 54.34±11.67 2 weeks 59.74±12.49 4 weeks 60.59±10.69 6 weeks 65.27±8.87 Within-group comparison

significant probability Week 0-2 0.0008* Weeks 0-4 0.028 Weeks 0-6 0.011* comparison between groups significant probability Week 0-2 1.000 Weeks 0-4 0.796 Weeks 0-6 0.489

*:p<0.05 Friedman test, p<0.017 Wilcoxon signed-rank test with a bonferroni method

As in Table 3, the control group using illite was 54.34±11.67 at week 0, 59.74±12.49 at 2 weeks, 4 weeks, and 6 weeks, respectively, 60.59±10.69, and 65.27±8.87 in both the experimental and control groups. It was found that the skin moisture level gradually increased as the experiment period progressed, and a statistically significant difference was found with p<0.017 (=5%/3) after 6 weeks of use compared to the use of both groups. there was

product after 2 weeks of use after 4 weeks of use after 6 weeks of use illite 9.94 11.51 20.12

The above table shows the change rate (%) of skin moisture content after using/after using the product of Example 1, and it was confirmed that the moisture content significantly increased after using a cosmetic composition containing an herbal complex extract containing illite as an active ingredient. .

[Experimental Example 2]

The skin pore number measurement experiment of the cosmetic cream containing the herbal complex extract of Example 2 as an active ingredient was performed and shown in Tables 5 and 6.

(Mean±SD) visit illite 0 weeks 12.44 ±13.43 2 weeks 11.78±12.00 4 weeks 11.44±12.62 6 weeks 11.33±11.58 Within-group comparison significant probability Week 0-2 0.339 Weeks 0-4 0.865 Weeks 0-6 0.394 comparison between groups significant probability Week 0-2 0.024 ^† Weeks 0-4 0.014 ^† Weeks 0-6 0.014 ^†

†:p<0.05 Mann-Whitney U test

This table shows the results of measuring the number of skin pores. In the control group using illite, 12.44 ± 13.43 at week 0, 11.78 ± 12.00, 11.44 ± 12.62, and 11.33 ± 11.58 at 2 weeks, 4 weeks, and 6 weeks, respectively, and it was found that the number of skin pores decreased. Therefore, the number of pores in the experimental group was all p<0 after 2 weeks, 4 weeks, and 6 weeks of use compared to before use. 017 (= 5%/3), and no significant difference was found in the control group.

product after 2 weeks of use after 4 weeks of use after 6 weeks of use illite -5.3 6 -8.04 -8.93

Table 6 shows the change rate (%) in the number of skin pores after using/after using the product of Example 2, and it was confirmed that pores were significantly reduced after using a cosmetic composition containing an herbal complex extract containing illite as an active ingredient. .

In Figure 2, a is the epidermis, b is the dermis, c is the subcutaneous fat layer, (1) is a picture showing the state in which the sebaceous glands are enlarged by acne bacteria and the pores are clogged, (2) is the herbal composite extract of Example 2 It shows a state in which a cosmetic product made of a cosmetic composition containing as an active ingredient is applied, and is absorbed into the epidermis and dermis as well as the surface of the skin to act as a sterilizer.

Formulation stability of a cosmetic product comprising a cosmetic composition containing the herbal composite extract of Example 2 as an active ingredient was tested. The subjects were asked to use the complex extract at a dose of 1.2g/4㎖ once every morning and evening, and the experiment was conducted for 6 months, and the scalp was photographed about once every 15 days. All clinical data are shown in Figs. 3 and 4, centering on changes in scalp and pores, hair growth and loss, etc. starting from the red marked part.

3 and 4, it can be seen that women in their 20s and men in their 50s also improved their scalp and prevented hair loss, making their hair thicker and richer.

In the present invention, herbal raw materials consisting of arborvitae, angelica, lobules, peppermint, moth, eoseongcho, and gosam are individually mixed with an extraction solvent, heated, and aged; Illite is mixed with an extraction solvent, heated, stirred, matured, and precipitated; Each of the heated and aged raw materials is filtered and centrifuged several times to prepare each herbal raw material extract, and each of the centrifuged herbal raw material extracts is mixed to contain the herbal composite extract as an active ingredient to prevent hair loss or scalp There is an improvement effect.

Claims (5)

It contains herbal complex extracts of Arborvitae extract, Angelica extract, leaf extract, peppermint extract, moth extract, houttuynia cordata extract, ginseng extract, and illite extract as active ingredients,
The herbal complex extract is
Herbal raw materials consisting of oriental cedar tree, angelica root, leaflet, peppermint, sandalwood bark, houttuynia cordata, and gosam separately mixed with an extraction solvent composed of 30% alcohol ethanol and distilled water in a 1: 1 volume ratio, followed by heating and maturing 1-1st step;
1-2 steps of mixing 20 parts by weight of illite with 100 parts by weight of an extraction solvent, stirring, aging, and precipitating by heating;
Each of the herbal raw materials according to steps 1-1 and 1-2 is first filtered to obtain a liquid extract, and the liquid extract is first filtered and then centrifuged to prepare each raw material solvent extract. Step 2; A first solvent extraction step comprising;
A third step of extracting each of the raw material solvent extracts from the first solvent extraction step by heating them in a vacuum distillation extractor at a pressure of 100 to 200 bar and a temperature of 40 to 60 ° C for 0.5 to 10 hours to generate steam; and
A fourth step of preparing each raw material vacuum distillation extract by cooling and condensing the water vapor at -5 to -10 ° C; A second vacuum distillation extraction step comprising a;
A cosmetic composition for preventing hair loss or improving the scalp, characterized in that produced by including. The method of claim 1,
The herbal composite extract is a cosmetic composition for preventing hair loss or improving scalp, which is prepared by heating and aging by mixing 30% alcohol and distilled water in an extraction solvent mixed in a 1: 1 volume ratio. The method of claim 1,
The cosmetic composition is contained in 0.05 to 80.0% (w / w) based on the total weight of the cosmetic, a cosmetic composition for preventing hair loss or improving the scalp. The method of claim 1,
The cosmetic composition is formulated into a topical application formulation of a lotion or spray, and softening lotion, astringent lotion, nutrient lotion, scalp agent, essence, scrub agent, powder, shampoo, rinse, serum, mist, hair that directly acts on the hair loss area A cosmetic composition for preventing hair loss or improving scalp having a formulation selected from the group consisting of conditioner, hair lotion, liquid tonic form, soap and cream. The method of claim 1,
The cosmetic composition is a cosmetic composition for preventing hair loss or improving the scalp, which is selected from shampoo, hair essence, hair conditioner, hair mist, cream, lotion, hair skin, mask pack and soap.

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