KR102395569B1 - Oral composition for tooth whitening - Google Patents

Abstract

The present invention provides a first agent comprising a peroxide; and a second agent comprising at least one peroxide activator selected from the group consisting of a heat generating agent, an alkali agent, and a metal salt, wherein any one of the first agent and the second agent is a paste , and the other one relates to an oral composition for teeth whitening, which is a dry film agent.

Description

Oral composition for teeth whitening {ORAL COMPOSITION FOR TOOTH WHITENING}

The present invention relates to an oral composition for whitening teeth.

The teeth are located in the oral cavity, and provide many roles, such as a mastication function as a primary function of digestion, and a pronunciation assistance function as a structure that serves as a standard by which detailed sounds can be distinguished during pronunciation. Teeth are made of dentin composed of apatite crystals, i.e., apatite, and enamel, i.e., surrounding the outside of dentin, enamel is translucent, whereas dentin is essentially yellow, giving teeth a usually yellow color, If your teeth are discolored from dark drinks or smoking, your teeth may be discolored from dark yellow to black.

However, as white teeth become the standard of beauty, there is a widespread demand for teeth whitening that changes the color of teeth white. Therefore, it is difficult to overcome the congenital dentin color and acquired tooth discoloration and change it to white teeth with simple brushing or scaling.

For teeth whitening, products containing a bleaching material such as hydrogen peroxide are applied to the teeth to allow the bleaching material to penetrate into the tooth to bleach the colored material. Due to instability, attempts have been made to stabilize the formulation.

Patent Document 1 below describes a composition in which a peroxide agent and a peroxide activator are separated into two agents of a paste/paste, and although this composition shows an improved whitening effect than a composition of a single formulation, the whitening target tooth area range However, the bleaching reaction occurred in the entire oral cavity, and in the end, it did not show a significant level of whitening improvement effect in the whitening target tooth area.

The following Patent Documents 2 and 3 describe a composition separated by a peroxide agent as a dry film and a peroxide activator having multiple layers, and such a composition can cause an effective bleaching reaction within the range of the target tooth area for whitening. Due to the interlayer transfer structure, it takes time for the bleaching reaction to occur, and the amount of the peroxide agent is limited, so that a significant level of whitening improvement effect was not shown.

Therefore, in the prior art, only tooth whitening agents focused on stabilizing the formulation of unstable peroxides exist, and there is no tooth whitening agent that can achieve a significant level of whitening improvement while intensively taking place in the desired whitening target tooth area range. didn't

Korean Patent Publication No. 877981 (2009.01.12) Korean Patent Publication No. 2004-0095898 (2004.11.16) Korean Patent Publication No. 553433 (2006.02.20)

The present invention provides an oral composition for teeth whitening that includes peroxide as a tooth whitening component, has excellent formulation stability, and can achieve a significant level of whitening improvement while intensively performing a bleaching reaction in a desired whitening target tooth area. want to

The present invention provides a first agent comprising a peroxide; and a second agent comprising any one or more selected from the group consisting of a heat generating agent, an alkali agent, and a metal salt, wherein any one of the first agent and the second agent is a paste, and the rest One provides an oral composition for teeth whitening, which is a dry film formulation.

The oral composition for whitening teeth according to the present invention is a tooth whitening component, in which peroxide and its activating component are separated into different formulations with a paste and a dry film, respectively, so that the formulation is stable, and the dry film is attached to the target area for effective whitening. It is possible to induce a bleaching reaction, and it is possible that the paste contains enough peroxide and one of the peroxide activators to cause an excellent bleaching reaction. is decomposed after the whitening reaction and can be easily removed together with the paste by rinsing the oral cavity with water.

In the present specification, "teeth" refers to bone tissue exposed to the outside of the oral epithelium of an animal, and in particular, although described based on human teeth, it should be construed to include animal teeth.

As used herein, “whitening” means increasing the brightness of the color of teeth.

Hereinafter, the oral composition for teeth whitening according to the present invention will be described in detail.

first agent

The oral composition for whitening teeth according to the present invention includes a first agent, and the first agent includes a peroxide.

The peroxide according to the present invention refers to a compound having a peroxide group (-OO-) or a carboxyl peroxide group (-C(=O)-OO-) or capable of generating hydrogen peroxide ions (O ₂ ^2- ), Peroxide bleaches the surface of teeth by oxidation/reduction action.

In one embodiment of the present invention, the peroxide is at least one selected from the group consisting of hydrogen peroxide, carbamide peroxide, calcium peroxide, sodium peroxide pyrophosphate and sodium percarbonate.

In an exemplary embodiment of the present invention, the content of the peroxide is 0.1 wt% to 20 wt% based on the total weight of the first agent. If the content of the peroxide is less than 0.1% by weight, an effective whitening effect cannot be derived, and if it exceeds 20% by weight, the peroxide stimulates the dental nerve, which causes soreness or a strong feeling of irritation and inflammation in the gums. .

second agent

The oral composition for whitening teeth according to the present invention includes a second agent, and the second agent includes any one or more peroxide activators selected from the group consisting of a heating agent, an alkali agent, and a metal salt.

The peroxide activator according to the present invention means to promote a reaction for generating free radicals from the peroxide or a reaction for generating hydrogen peroxide ions (O ₂ ^2- ).

Among the peroxide activators according to the present invention, the exothermic agent promotes the reaction by increasing the temperature of the peroxide.

In one embodiment of the present invention, the exothermic agent is zeolite, calcium chloride, or a mixture thereof.

In one embodiment of the present invention, the zeolite is not particularly limited as long as it reacts with water to generate heat. For example, general formula xM _{2 / n} O·Al of zeolite A, zeolite X, zeolite Y, zeolite L, etc. ₂ O ₃ySiO ₂·zH ₂ O (wherein x, y, and z represent arbitrary numbers, M represents an alkali metal or alkaline earth metal, and n represents the valence thereof) is an anhydride of zeolite.

In an exemplary embodiment of the present invention, the content of the heating agent is 5 to 50% by weight based on the total weight of the second agent. When the content of the pyrogen is less than 5% by mass, the effect of heating during brushing was hardly felt, and when the content of the exothermic agent was more than 50% by mass, pain was felt during brushing due to excessive heat, and the film formulation was not well made.

Among the peroxide activators according to the present invention, the alkali agent promotes the reaction by adjusting the pH of the peroxide to 8 to 11.

In one embodiment of the present invention, the alkali agent is any one or more selected from the group consisting of sodium hydroxide, sodium bicarbonate and sodium percarbonate.

In one embodiment of the present invention, the content of the alkali agent is 0.01 wt% to 5 wt% based on the total weight of the second agent. If the content of the alkali agent is less than 0.01% by weight, the effect of the activator is insignificant, and if it is more than 5% by weight, it may be activated too quickly or give irritation to the teeth or gums.

The metal salt in the peroxide activator according to the present invention promotes the reaction by releasing metal ions that promote decomposition of hydrogen peroxide. The metal ^ion that promotes the decomposition of hydrogen peroxide may be, for example, Fe ³⁺ , Cu ²⁺ , Al ^{3+ ,} or ^{Mn 2+ .}

In one embodiment of the present invention, the metal salt is selected from the group consisting of iron chloride, iron sulfate, iron nitrate, copper sulfate, copper nitrate, aluminum sulfate, aluminum potassium sulfate, manganese sulfate, manganese gluconate, manganese citrate, and manganese dioxide any one or more

In an exemplary embodiment of the present invention, the content of the metal salt is 0.001 wt% to 1 wt% based on the total weight of the second agent. When the content of the metal salt is less than 0.001% by weight, the effect of the activator is insignificant, and when the content of the metal salt is more than 1% by weight, it may be activated too quickly or give irritation and bad taste to teeth or gums.

paste

In the oral composition for teeth whitening according to the present invention, any one of the first agent and the second agent is a paste.

The paste according to the present invention basically means a single composition that is in a liquid phase at room temperature, but when a shear stress is applied at room temperature, all or part of it may be in a solid state in which continuous deformation occurs and viscosity exists, and the formulation is particularly limited However, it may be in a liquid or liquid-dispersed form, and specifically, a solution formulation, a gas/liquid foam formulation, a liquid/liquid emulsion formulation, a solid/liquid of a sol formulation, a liquid/solid suspension formulation, or a liquid/solid gel formulation.

In one embodiment of the present invention, the viscosity of the paste is 20,000 cps to 1,600,000 cps. If the viscosity of the paste is less than 20,000 cps, the viscosity is too low, the formulation stability is deteriorated, and if it exceeds 1,600,000 cps, the viscosity is too high, so there is a problem in use.

In the present specification, the viscosity value means a viscosity value measured at a temperature of 25° C. and 1 atmosphere pressure using a viscometer manufactured by Brookfield Engineering Laboratories, Inc. under the trade name LVT-RV.

In an exemplary embodiment of the present invention, as a wetting agent component, glycerin, sorbitol solution, polyethylene glycol, propylene glycol, etc. are mixed alone or in a mixture of two or more types, based on the total weight of the paste, in an amount of 20% to 60% by weight. It is further added to the paste.

In one embodiment of the present invention, the foaming agent includes polyoxyethylene sorbitan fatty acid ester, polyoxyethylene (hardened) castor oil, glycerin fatty acid ester, sorbitan fatty acid ester, Nonionic surfactants such as sucrose fatty acid esters, alkylolamides, and alkyl glucosides, or cationic surfactants such as N-alkyldiamino ethyl glycine are mixed alone or in mixture of two or more types, based on the total weight of the paste, 0.5% by weight It is further added to the paste in an amount of from 0.5% to 8% by weight to 10% by weight, preferably from 0.5% to 8% by weight.

In one embodiment of the present invention, as a binder, hydroxyethyl cellulose, hydroxypropyl cellulose, xanthan gum, carrageenan, sodium alginate, etc. are mixed alone or two or more types are mixed with respect to the total weight of the paste, 0.1 wt% to 5% It is further added to the paste in an amount of from 0.1% to 2% by weight, preferably from 0.1% to 2% by weight.

In one embodiment of the present invention, as the sweetener, saccharin, sodium saccharin, aspartame, stevioside, xylitol, licoric acid, etc. alone or by mixing two or more types, based on the total weight of the paste, 0.05% to 5% by weight The content is further added to the paste.

In an exemplary embodiment of the present invention, citric acid, tartaric acid, phosphoric acid, etc. are used alone or mixed with two or more types as an acidic pH adjuster, and methyl paraoxybenzoate, propyl paraoxybenzoate, sodium benzoate alone or two or more types are mixed as preservatives. and further added to the paste.

In one embodiment of the present invention, active ingredients include sodium fluoride, sodium monofluorophosphate, tin fluoride, chlorhexidine, allantoin chlorohydroxyaluminate, aminocaproic acid, triclosan, cetylpyridium chloride, zinc chloride, Pyridoxine hydrochloride, tocopherol acetate, etc. are used alone or in a mixture of two or more types, peppermint oil, spearmint oil, menthol, anetol, etc. are used in an appropriate amount as a fragrance, titanium oxide is used as a brightener, and edible as a colorant Purified water and ethanol are used as a dye and a solvent according to a conventional toothpaste manufacturing method.

dry film

In the oral composition for teeth whitening according to the present invention, when the first agent is the paste, the second agent is a dry film agent, and when the second agent is the paste agent, the first agent is a dry film agent.

The dry film agent according to the present invention means a sheet-type solid dosage form having a length, width and thickness by drying the composition having the composition of the first agent or the second agent, and the length and The width is not limited as long as an area capable of covering one or more teeth is secured.

The dry film agent according to the present invention comprises a step of forming a film with a composition containing the components of the first agent or a composition containing the components of the second agent; drying the composition containing the components of the first agent or the composition containing the components of the second agent; or a combination of these processes.

The film forming process may include the blown film process, a cast film process, a thermoforming process, a vacuum forming process, or an extrusion coating process. , it is not limited as long as it can be dried to form a sheet-type solid dosage form having a length, width and thickness.

In the present specification, when the first agent or the second agent is a dry film agent, the content of the composition means the composition in a mixture state before the first agent or the second agent goes through the film forming process or the drying process. .

The composition for teeth whitening according to the present invention may have a liquid form, specifically, a paste form having viscosity, and may further include a toothpaste component commonly used in the art, but preferably by removing moisture to be described later. It may be in a dried film formulation.

In one embodiment of the present invention, the average thickness of the dry film agent is 0.05 mm to 0.5 mm. When the thickness of the dry film agent is less than 0.05 mm, it is difficult to achieve an effective whitening effect because the film is too thin. There is a problem.

In one embodiment of the present invention, the dry film agent further contains a water-insoluble polymer or a semi-water-soluble polymer. The water-insoluble polymer or semi-water-soluble polymer may maintain a solid state at room temperature, and is not limited as long as it is not completely dissolved when in contact with saliva. For example, cellulose acetate phthalate, polyvinyl acetate, ethyl cellulose, polymethyl methacrylate, methacryloyl ethyl betaine/methacrylate copolymer (Yukaformer: manufactured by Mitsubishi, methacryloylethyl betain/methacrylate copolymer), methacrylic Acid copolymer (methacrylic acid copolymer; Eudragit L 100, Eudragit L 12,5, Eudragit L 100-55, Eudragit L 30D-55), aminoalkyl methacrylate copolymer; Eudragit E 100, Eudragit E 12 ,5, Eudragit RL 100, Eudragit RL 30D.

In one embodiment of the present invention, the content of the water-insoluble polymer or the semi-water-soluble polymer is 20% to 60% by weight based on the total weight of the first agent or the second agent. When the content of the polymer is less than 20% by weight, it is difficult to uniformly form a film with a thickness of more than a certain thickness, and when it is more than 60% by weight, the solubility is lowered, so that it does not dissolve sufficiently during brushing, resulting in poor feeling of use.

In one embodiment of the present invention, the first agent is the paste, and the second agent is the dry film agent.

In one embodiment of the present invention, the second agent is the paste, and the first agent is the dry film agent.

chelating agent

In one embodiment of the present invention, the first agent or the second agent is selected from the group consisting of tetrasodium pyrophosphate, sodium acid pyrophosphate, sodium tripolyphosphate, sodium hexametaphosphate, and acidic polyphosphate Any one or more chelating agents are further included.

In one embodiment of the present invention, the content of the chelating agent is 0.01 wt% to 5 wt% based on the total weight of the first agent or the second agent.

Hereinafter, the present invention will be described in more detail by way of Examples. However, these examples are only intended to describe the present invention in detail, and the scope of the present invention is not limited by these examples.

< Reference example 1> paste Preparation of the composition

Compositions of pastes 1 and 2 were respectively prepared with the composition of Table 1 below (unit: weight % with respect to the total weight of the paste), and the specific process is as follows. First, polyethylene glycol and glycerin, which are polyols, were placed in a container, and then sodium saccharin, sodium monofluorophosphate and polyvinylpyrrolidone were dissolved or dispersed at a temperature of 70 to 80 °C. Then, in a vacuum state, hydrous silicic acid, anhydrous zeolite (used only for paste 2), and sodium lauryl sulfate were added and stirred well for 20 minutes. Thereafter, after cooling to 40° C., perfume and hydrogen peroxide (used only in the case of paste 1) were put into a container and dissolved for 20 minutes to prepare a paste composition.

ingredient paste 1 paste 2 Polyethylene glycol ^{1 )} 37.94 29.94 glycerin ^{2 )} 35.00 25.00 Spices ^{3 )} 1.00 1.00 Sodium Lauryl Sulfate ^{4 )} 2.00 2.00 Sodium Saccharin ^{5 )} 0.30 0.30 Sodium monofluorophosphate ^{6 )} 0.76 0.76 polyvinylpyrrolidone ^{7 )} 1.00 1.00 functional silicate ^{8 )} 20.00 20.00 Anhydrous zeolite ^{9 )} - 20.00 Hydrogen peroxide (concentration 35%) ¹⁰⁾ 2.00 -

1) Dow Chemical/CARBOWAX SENTREY POLYETHYLENE GLYCOL 400 NF

2) LG Household & Health Care/ELOGLYN R995

3) Takasako/Flavor

4) KAO/Emal 10PT

5) KAIFENG XINGHUA FINE CHEMICAL/SODIUM SACCHARIN

6) HUBEI XINGFA CHEMICALS GROUP CO./Sodium Monofluorophosphate

7) Basf/Luviskol K30

8) Rhodia/TIXOSIL 43K

9) Gsim Tech/JST-Calolite (LP)

10) Hansol Chemical/HP 35M, the content of hydrogen peroxide in the paste 1 is 0.7% by weight based on the total weight of the paste

In addition, as a result of measuring the viscosity of the paste composition prepared at a temperature of 25° C. and a pressure of 1 atmosphere using a viscometer under the trade name LVT-RV manufactured by Brookfield Engineering Laboratories, Inc., the viscosity of the paste 1 was 400,000 cps, and the paste was The viscosity of 2 was 440,000 cps.

< Reference example 2> Preparation of dry film

Dry film agents 1 to 3 were respectively prepared with the composition shown in Table 2 below (unit: weight % with respect to the total weight of the composition), and the specific process is as follows.

First, purified water and ethanol are put in a container, and then, polyethylene glycol and polyvinylpyrrolidone are slowly added at a temperature of 50°C to 60°C, and dissolved while stirring using an azimuth mixer for 20 minutes. After cooling to 25 °C, the remaining components were put into a container at once, and dissolved and dispersed for 20 minutes to prepare a mixed composition.

After degassing by standing still for 30 minutes, 100 g of the mixture composition was cast on a silicone-treated polyester film and dried in a hot air dryer at 50° C. for 20 minutes to prepare a dry film.

As a result of measuring the average thickness of the prepared dry films 1 to 3, all were 0.25 mm.

Ingredient name Dry film agent 1 Dry film agent 2 Dry film agent 3 Eudragit ^{1 )} 20.00 20.00 20.00 polyvinylpyrrolidone ^{2 )} 10.00 10.00 10.00 Sodium lauryl sulfate ³⁾ 8.00 8.00 8.00 zeolite ⁴⁾ 10.00 - - Calcium carbonate ⁵⁾ - 10.00 10.00 saccharin ⁶⁾ 0.60 0.60 0.60 Polyethylene glycol ^{7 )} 5.00 5.00 5.00 spices ⁸⁾ 2.00 2.00 2.00 Hydrogen peroxide (concentration 35%) ^{9 )} - - 2.00 ethanol ^{11 )} 44.40 44.40 42.40

1) EVONIK/EUDRAGIT E PO

2) Basf/Luviskol K30

3) KAO/Emal 10PT

4) Gsim Tech/JST-Calolite (LP)

5) Baekkwang Industrial/BKEIFG-1000

6) KAIFENG XINGHUA FINE CHEMICAL/SODIUM SACCHARIN

7) Dow Chemical/CARBOWAX SENTREY POLYETHYLENE GLYCOL 400 NF

8) Takasako/Flavor

9) Hansol Chemical/HP 35M, the content of hydrogen peroxide in the dry film agent 3 is 0.7% by weight based on the total weight of the composition

10) Samjeon/Ethyl Alcohol, concentration 95.0%

< Reference example 3> 2 formulations Preparation of oral composition for whitening

Using the paste and dry film agent prepared in Reference Examples 1 and 2, a combination of Examples 1 and Comparative Examples 1 to 3 as shown in Table 3 below was used to prepare a two-part oral composition for whitening.

first agent second agent Example 1 paste 1 Dry film agent 1 Example 2 Dry film agent 3 paste 2 Comparative Example 1 paste 1 Dry film agent 2 Comparative Example 2 paste 1 paste 2 Comparative Example 3 Dry film agent 1 Dry film agent 3

< test example 1> Teeth whitening effect measurement test (In Vivo )

In order to measure the tooth whitening effect of the toothpaste for teeth whitening according to the present invention, 100 healthy male and female experimenters were selected as a sample and tooth brightness before and after use was measured.

The test group was divided into 5 groups in which Examples 1 and 2 and Comparative Examples 1 to 3 were applied, respectively, and the original tooth color of the subject was measured using SHADEEYE-EX (SHOFU Co.LTD., Japan). .

Apply the SHADEEYE-EX tip to the maxillary left central incisor 2 mm above the buccal surface and at a right angle to the tooth surface in the middle of the mesiodistal and mesial distal to irradiate a beam to measure and collect baseline (primary reference value) data. Each group was instructed to brush their teeth 3 times a day as follows.

Test group of Example 1: After attaching the second agent to the teeth, brushing the teeth for 3 minutes after applying the first agent to the toothbrush,

Test group of Example 2: After attaching the first agent to the teeth, brushing the teeth for 3 minutes after applying the second agent to the toothbrush,

Test group of Comparative Example 1: After attaching the second agent to the teeth, brushing teeth with the first agent for 3 minutes,

Test group of Comparative Example 2: After soaking the first agent and the second agent together on a toothbrush, brushing lipids, and

Test group of Comparative Example 3: After attaching the first agent to the teeth, the second agent was applied thereon and brushing teeth.

During the test period, food was consumed according to one's usual eating habits, but coffee, cola, and tobacco were prohibited before the color measurement on the day of color measurement. After 1 month of use, the chromaticity was measured (secondary measurement).

SHADEEYE-EX, used for optical colorimetry in this experiment, is a colorimeter dedicated to measuring the color tone of natural teeth. After irradiating a certain amount of light to the teeth, the amount of reflected light through the three filters of red, yellow, and blue is already input to the machine. -shade guide color system (in order of brightness C4=16, A4=15, C3=14, B4=13, A3.5=12, B3=11, D3=10, A3=9, D4=8, C2=7, C1=6, A2=5, D2=4, B2=3, A1=2, B1=1) and color are compared and analyzed and the corresponding brightness value is output. and at the second measurement after 1 month, the average values for each group were averaged and shown in Table 4 below.

primary measurement
(baseline average) secondary measurement
(average value after 1 month) Example 1 7.9 6.14 Example 2 7.92 6.25 Comparative Example 1 7.89 7.32 Comparative Example 2 7.87 6.94 Comparative Example 3 7.91 6.84

In addition, if the tooth brightness value of the secondary measurement is lower than the tooth brightness value of the primary measurement, "improvement", if the tooth brightness value of the secondary measurement is the same than the tooth brightness value of the primary measurement, "no change", When the tooth brightness value of the secondary measurement was higher than the tooth brightness value, it was determined as "deteriorating", and the number of people according to the determination result and the standard ratio of the number of people in each group are shown in Table 5 below.

improvement no change worse Example 1 15 (75%) 5 (25%) 0 (0%) Example 2 14 (70%) 6 (30%) 0 (0%) Comparative Example 1 4 (20%) 16 (80%) 0 (0%) Comparative Example 2 7 (35%) 13 (65%) 0 (0%) Comparative Example 3 7 (45%) 11 (55%) 0 (0%)

The result value of tooth brightness by SHADEEYE-EX is not affected by non-color environmental conditions, and by minimizing the tip diameter of the measuring instrument and reducing errors in the direction, absorption, and reflection of light, natural tooth colorimetry is performed to express the color tone of natural teeth sensibly. Rather, it is possible to obtain a specific value of tooth brightness. The tooth brightness value is a total of 16 steps, and the lower the value, the brighter the tooth.

In Table 4, Comparative Examples 1 to 3 showed a decrease in the average value of the tooth brightness value for 1 month, but it was insignificant than that of Examples 1 or 2, and in Table 5, the number of people who actually improved the tooth brightness was carried out Examples 1 and 2 had more than 2/3 of the number of people in the group, whereas Comparative Examples 1 to 3 had no improvement in tooth brightness by 50% or at most 80% of the group.

Therefore, Comparative Example 1 of Examples 1 and 2 according to the present invention, which is a paste containing a peroxide, and a dry film preparation without a peroxide activator, Comparative Example 1, a paste containing a peroxide, and a paste containing a peroxide activator, the second agent It was confirmed that the tooth brightness improvement, that is, the teeth whitening improvement effect, was superior to Comparative Example 2 of the formulation, and Comparative Example 3 of the first agent containing a peroxide-containing dry film agent and the second agent containing a peroxide active agent-containing dry film agent.

Claims (11)

a first agent comprising at least one peroxide selected from the group consisting of hydrogen peroxide, carbamide peroxide, calcium peroxide, sodium peroxide and sodium percarbonate; and
An oral composition for teeth whitening with improved bleaching reaction of the tooth surface comprising;
The first agent is a paste, the second agent is a dry film agent,
An oral composition for teeth whitening with improved bleaching reaction of the tooth surface, characterized in that the paste is applied after attaching the dry film agent to the teeth. According to claim 1,
The oral composition for whitening teeth with improved bleaching reaction of the tooth surface, wherein the peroxide is hydrogen peroxide. According to claim 1,
The second agent is sodium hydroxide, sodium bicarbonate and any one or more alkali agents selected from the group consisting of sodium percarbonate as a peroxide activator, the oral composition for teeth whitening with improved bleaching reaction of the tooth surface further comprising. The method of claim 1,
The second agent is peroxide activation of any one or more metal salts selected from the group consisting of iron chloride, iron sulfate, iron nitrate, copper sulfate, copper nitrate, aluminum sulfate, aluminum potassium sulfate, manganese sulfate, manganese gluconate, manganese citrate, and manganese dioxide. An oral composition for teeth whitening with improved bleaching reaction of the tooth surface that further comprises zero. The method of claim 1,
The first agent or the second agent further comprises any one or more chelating agents selected from the group consisting of tetrasodium pyrophosphate, sodium acid pyrophosphate, sodium tripolyphosphate, sodium hexametaphosphate, and acidic polyphosphate An oral composition for teeth whitening with improved bleaching reaction of the tooth surface. According to claim 1,
The viscosity of the paste is 20,000 cps to 1,600,000 cps oral composition for teeth whitening with improved bleaching reaction of the tooth surface. According to claim 1,
The average thickness of the dry film agent is 0.05 mm to 0.5 mm oral composition for teeth whitening with improved bleaching reaction of the tooth surface. According to claim 1,
The weight ratio of the peroxide and the zeolite is 2:10, an oral composition for teeth whitening with an improved bleaching reaction on the tooth surface. According to claim 1,
The first agent and the second agent each further comprises an anionic surfactant, an oral composition for teeth whitening with improved bleaching reaction of the tooth surface. 10. The method of claim 9,
The anionic surfactant is sodium lauryl sulfate, an oral composition for teeth whitening with improved bleaching reaction of the tooth surface. 10. The method of claim 9,
The weight ratio of the peroxide and the anionic surfactant in the first agent is 1:1,
In the second agent, the weight ratio of zeolite and anionic surfactant is 10: 8, an oral composition for teeth whitening with improved bleaching reaction of the tooth surface.