KR102295720B1 - Aqueous adhesive composition for medical adhesive and medical adhesive sheet using thereof - Google Patents

Abstract

The present invention relates to a structural unit derived from one or two or more (meth)acrylic acid ester monomers (A), a structural unit derived from the crosslinkability imparting monomer (B), and a structural unit derived from a functional monomer (C). A copolymer comprising; Surfactants; And water; it relates to an aqueous pressure-sensitive adhesive composition comprising a.

Description

Aqueous pressure-sensitive adhesive composition used for medical adhesive cloth and medical pressure-sensitive adhesive sheet using same {AQUEOUS ADHESIVE COMPOSITION FOR MEDICAL ADHESIVE AND MEDICAL ADHESIVE SHEET USING THEREOF}

The present invention relates to an aqueous pressure-sensitive adhesive composition for use in a medical adhesive cloth, comprising a specific acrylic copolymer, a surfactant, and water, and a medical pressure-sensitive adhesive sheet using the same.

In the case of medical adhesive cloth, it is a widely used over-the-counter drug used by many age groups by attaching it to the skin surface in order to produce anti-inflammatory and pain-relieving effects.

However, in the case of the adhesive used for the close-fitting fabric, almost all of it has been used up to now, and among the prior art, it relates to a medical patch showing a decrease in drug effect and skin irritation by using a weakly basic functional group present in an oil-based acrylic block polymer. Although there is a patent (Patent Document 1), in the end, due to the organic solvent used as a solvent, some of VOCs (volatile organic compounds) are exposed to deteriorate the health of workers, and there is a lot of risk of fire, which causes various environmental problems. In addition, the problem of causing skin irritation in some people due to the organic solvent remaining in the adhesive layer is also occasionally occurring.

As the industry gradually develops, environmental problems of workers and the dangers of chemical raw materials used are emerging a lot recently, and legal sanctions have arisen and are currently being implemented. As interest in safety in the media is gradually increasing, legal regulations on the use of organic solvents have been gradually strengthened. In particular, in the case of medical adhesives used directly on the human body, due to skin irritation or VOCs (volatile organic compounds) emission issues, eco-friendly products The demand is growing.

To overcome the above problems, many manufacturers have been spurring development from the past to develop water-based acrylic pressure-sensitive adhesives, precisely to solve the problem with water-based acrylic copolymer polymerization products. The problem has not been improved, and the surfactant required for synthesis is likely to cause skin irritation, making it difficult to develop.

In the case of the current oil-based adhesive, the shape is in the form of a linear chain, and the surface tension is low, so that the coating property and bonding strength with the substrate are excellent.

On the other hand, in the case of aqueous, the particle shape is dispersed in water, and each particle has a polymer in the surfactant aggregate called micelles. Compared to oil-based properties, the film has a lower density and significantly lower bonding strength with the substrate. Even if the adhesive properties are synthesized to be equivalent to oil, coating properties and bonding strength to the substrate are low, so that the problem of separation from the substrate occurs frequently, making it difficult to meet the required workability.

Korean Patent Publication No. 10-2018-0059870

Under these circumstances, the object of the present invention is to have adhesive properties equivalent to those of conventional oil-based acrylic adhesives used in medical adhesive cloths, and VOCs (volatile organic compounds) are not detected by solvents, so there is no skin irritation, and safe water compared to oily Aqueous adhesive can be manufactured by polymerization of an aqueous acrylic copolymer using An object of the present invention is to provide a water-based pressure-sensitive adhesive composition that uses a special surfactant used for raw materials, secures the bonding force between the pressure-sensitive adhesive and the adhesive cloth, and replaces the oil-based pressure-sensitive adhesive.

The present inventors have identified a structural unit derived from one or two or more (meth)acrylic acid ester monomers (A), a structural unit derived from the crosslinkability imparting monomer (B), and a structural unit derived from a functional monomer (C). A copolymer comprising; Surfactants; And water; by using an aqueous pressure-sensitive adhesive composition comprising a found that the above problems can be solved, and completed the present invention.

Specifically, the present invention provides the following.

1) a structural unit derived from one or more (meth)acrylic acid ester-based monomers (A), a structural unit derived from a crosslinkability imparting monomer (B), and a structural unit derived from a functional monomer (C) a copolymer;

Surfactants;

and water; comprising,

Aqueous pressure-sensitive adhesive composition.

2) In 1), the monomer (A) is butyl (meth)acrylate, t-butyl (meth)acrylate, 2-ethylhexyl (meth)acrylate, i-octyl (meth)acrylate, n -Octyl (meth) acrylate, ethyl (meth) acrylate, methyl (meth) acrylate, n- propyl (meth) acrylate and i- propyl (meth) acrylate selected from the group consisting of one or two or more An aqueous pressure-sensitive adhesive composition, characterized in that it is a monomer.

3) In 1), the monomer (C) is tridecyl acrylate, stearyl acrylate, trimethylolpropane triacrylate, 2-hydroxypropyl (meth)acrylate, 2-hydroxyethyl (meth) Acrylate, diacetone acrylamide, trimethylolpropane tri(meth)acrylate (TMPTA), acetoacetoxyethyl (meth)acrylate, allyl (meth)acrylate, diethyl glycol diacrylate, 1,6-hexane An aqueous pressure-sensitive adhesive composition, characterized in that at least one selected from the group consisting of diol diacrylate and tripropylene glycol diacrylate (TPGDA).

4) The water-based pressure-sensitive adhesive composition according to 1), wherein the copolymer contains 0.1 to 10 parts by weight based on 100 parts by weight of the copolymer (C).

5) The aqueous pressure-sensitive adhesive composition according to 1), wherein the copolymer is in the form of particles having a particle size of 50 to 300 nm.

6) The surfactant according to 1), wherein the surfactant is polyethylene alkylphenol ester, ammonium sulfate, sodium lauryl sulfate, ammonium dodecyl benzene sulfonate, sulfosuccinate, sodium dioctyl sulfosuccinate, sulfuric acid ester salt, poly selected from the group consisting of oxyethylene alkyl ethers, fatty acid sorbital esters, fatty acid diethanol amines, alkyl monoglyceryl ethers, alkyl sulfuric ester salts, alkylpolyoxyethylene sulfates, sodium polyoxyethylene alkyl ether sulfates and alpha olefin sulfonates. Characterized in that, the aqueous pressure-sensitive adhesive composition.

7) The aqueous pressure-sensitive adhesive composition according to 1), wherein the surfactant is included in an amount of 0.5 to 5 parts by weight based on 100 parts by weight of the copolymer.

8) The water-based pressure-sensitive adhesive composition according to 1), wherein the copolymer has a solid content of 50% by weight or more.

9) The aqueous adhesive composition according to any one of 1) to 8), wherein the composition is for a medical adhesive cloth.

10) An adhesive sheet comprising the aqueous adhesive composition according to any one of 1) to 8).

The present invention has adhesive properties equivalent to those of conventional oil-based acrylic adhesives used in medical adhesive fabrics, and does not cause skin irritation because VOCs (volatile organic compounds) are not detected by solvents, and is a water-based acrylic copolymer using water, which is safer than oil-based. A special interface used for cosmetic raw materials or food raw materials that is harmless to skin irritation that has been approved as a reactive surfactant (reactive surfactant having a double bond reactive group) or some FDA approval while securing coating properties while being able to manufacture aqueous adhesive by polymerization While using the active agent, it is possible to provide an aqueous adhesive composition that secures the bonding force between the adhesive and the adhesive fabric and replaces the oil-based adhesive for the adhesive fabric.

1 shows crosslinking and density increase according to particle size control and use of a reactive emulsifier.

Description in this specification WHEREIN: For example, "(meth)acrylic acid" is used as a word which shows both "acrylic acid" and "methacrylic acid", and the same applies to other similar terms.

Hereinafter, the aqueous adhesive composition of this invention is demonstrated.

The aqueous adhesive composition of the present invention comprises a structural unit derived from one or two or more (meth)acrylic acid ester monomers (A), a structural unit derived from a crosslinkability imparting monomer (B), and a functional monomer (C) copolymers comprising structural units derived from; Surfactants; and water;

[Copolymer]

The copolymer of the present invention has a distribution in which the solid content is 50% by weight or more, that is, 50 to 100% by weight, preferably 50 to 65% by weight, more preferably 50 to 60% by weight. If the solid content exceeds 65% by weight, the viscosity becomes too high and it is difficult to control the coating thickness. If the solid content is less than 50% by weight, the viscosity is too low and the coating property is significantly reduced when applied to a roll coater. By applying the viscosity range of 4,000 ~ 6,000 cps, it is possible to secure coating properties.

The copolymer of the present invention may be in the form of particles, and in order to secure coatability, a particle diameter of 50 to 300 nm, preferably 80 to 180 nm, may be used. When the particle diameter of the particles is less than 50 nm, the viscosity of the aqueous acrylic copolymer car agent becomes too high, so it is difficult to control the coating thickness. As the voids increase, the bonding strength with the adhesion fabric base material decreases. Therefore, it is preferable to synthesize the particles with a particle diameter of about 80 to 180 nm.

Depending on the type of surfactant and the addition method of the pre-copolymer (copolymer used during the reaction), the copolymer particle distribution can be variously adjusted. The method of controlling the particle distribution is as follows. When the initial reaction is performed as a part of the pre-copolymer, most of the particles are formed in a similar size at this time, and most of the particles are polymerized in the generated particles, so the particle size is mostly constant and regularly synthesized. However, when the main reaction is started immediately without an initial reaction in order to form particles of various shapes, the particle distribution can be broadened because they are initially formed in various types of particles.

When the particle distribution value (PdI) is low, it is close to a uniform particle, and when it is high, it is composed of broadly various particle sizes. When the particle distribution is wide, the gap between the particles becomes narrower, and as the density increases, the particles are more closely adhered to each other during film formation and the coating property is improved. The particle distribution value (PdI) is preferably 0.006 to 0.05, more preferably 0.02 to 0.04.

The copolymer of the present invention is a structural unit derived from one or two or more (meth)acrylic acid ester monomers (A) (hereinafter also referred to as 'monomer (A)'), a crosslinking monomer (B) (hereinafter, It includes a structural unit derived from a 'monomer (B)') and a structural unit derived from a functional monomer (C) (hereinafter also referred to as a 'monomer (C)').

<(meth)acrylic acid ester monomer (A)>

The monomer (A) is not particularly limited, but may be a (meth)acrylic acid ester-based monomer having 1 to 18 carbon atoms, for example, butyl (meth)acrylate, t-butyl (meth)acrylate, 2-ethylhexyl (meth) acrylate, hexyl acrylate, i-octyl (meth) acrylate, n-octyl (meth) acrylate, ethyl (meth) acrylate, methyl (meth) acrylate, n-propyl ( It may be selected from the group consisting of meth)acrylate and i-propyl (meth)acrylate.

<Crosslinkability imparting monomer (B)>

The monomer (B) may be included in an amount of 0.1 to 15 parts by weight, preferably in an amount of 0.5 to 3 parts by weight, based on 100 parts by weight of the copolymer. If the content of the crosslinkability imparting monomer (B) is less than 0.1 parts by weight based on 100 parts by weight of the copolymer, the cohesive force is lowered, and when it exceeds 15 parts by weight, the degree of crosslinking becomes too high, resulting in formation of aggregates during the reaction or a significant increase in viscosity. occurs

The monomer (B) is not particularly limited, but may be an acrylic monomer having 1 to 18 carbon atoms, for example, acrylic acid, methacrylic acid, itaconic acid, maleic acid, formic acid, formic acid, acetic acid, etc. species or two or more species may be used.

<Functional monomer (C)>

A functional monomer (C) may be used in the copolymer to compensate for the insufficient bonding strength of the substrate with the adhesive fabric. The functional group of the functional monomer (C) and the reactive group of the surfactant complement the bonding force between the adhesive fabric substrate.

The monomer (C) may be included in an amount of 0.1 to 10 parts by weight, preferably 0.1 to 6 parts by weight, based on 100 parts by weight of the copolymer. If the content of the monomer (C) is too small to less than 0.1 parts by weight based on 100 parts by weight of the copolymer, a problem in which the adhesive is transferred to the skin occurs. As the adhesiveness of the adhesive decreases, there is a problem that the adhesive fabric peels off itself, or the drug part and the adhesive part peel off.

Although the monomer (C) is not particularly limited, for example, tridecyl acrylate, stearyl acrylate, trimethylolpropane triacrylate, 2-hydroxypropyl (meth)acrylate, 2-hydroxyethyl ( meth) acrylate, diacetone acrylamide, acetoacetoxy trimethylolpropane tri (meth) acrylate (TMPTA), acetoacetoxyethyl (meth) acrylate, allyl (meth) acrylate, diethyl glycol diacrylate, At least one selected from the group consisting of 1,6-hexanediol diacrylate, tripropylene glycol diacrylate (TPGDA), acrylamide, and glycidyl (meth)acrylate may be used.

[Surfactants]

The amount of the surfactant may be used in the range of 0.5 to 5 parts by weight, more preferably in the range of 0.8 to 3.5 parts by weight, based on 100 parts by weight of the copolymer, which is an optimal ratio for stability.

As the surfactant, an anionic surfactant may be used alone, or one or two or more types may be used, and more preferably, an anionic surfactant and one or more nonionic surfactants may be used for synthesis.

Although it does not specifically limit as surfactant, For example, polyethylene alkylphenol ester, ammonium sulfate, sodium lauryl sulfate, ammonium dodecyl benzene sulfonate, sulfosuccinate, sodium dioctyl sulfosuccinate, sulfuric ester salt , polyoxyethylene alkyl ether, fatty acid sorbital ester, fatty acid diethanolamine, alkyl monoglyceryl ether, alkyl sulfate ester salt, alkyl polyoxyethylene sulfate, sodium polyoxyethylene alkyl ether sulfate, alpha olefin sulfonate, etc. have.

In addition, as a surfactant, use a cosmetic or food surfactant that is harmless to skin irritation, or use a reactive surfactant (with a double bond group) to reduce pores through crosslinking between particles to reduce oiliness and moisture from the skin. By preventing the penetration of branches, it is possible to improve the change in adhesive strength over time.

More specifically, a reactive emulsifier containing at least one double bond may be used. There are anionic and nonionic types, wherein the anionic reactive emulsifiers are SR-10, SR-30, SR-1025, SR-1035, KH-05, KH-10, BC-05, BC-10, BC by DKS. -20, BC-30, PD-104 from KAO, etc. Nonionic reactive emulsifiers ER-10, ER-20, ER-30, ER-40 from Adeka, RN-10, RN-20 from DKS , RN-30, RN-50, and the like. In addition, eco-friendly reactive emulsifier that is APE free or KAO's E-118B, which is used for transdermal use such as cosmetics, can be used.

The viscosity range of the final adhesive product is preferably within 2,000 to 8,000 cps, more preferably around 4,000 to 6,000 cps, when measured at 25 ° C using a brookfeild LV Viscometer, the standard of oil-based roll coating. If it is more than 8,000 cps, it is difficult to control the coating.

Hereinafter, it will be described in detail through examples.

<raw material used>

KAO E-118B: Sodium polyoxyethylene alkyl ether sulfate

DKS Hitenol KH-10: Sodium polyoxyethylene alkyl ether sulfuric ester

ADEKA SR-10 : Sodium polyoxyethylene alkyl ether sulfuric ester

SOLVAY DS-4: Sodium dodecyl (branched)benzene sulfonate

2-EHA: 2-ethylhexyl acrylate,

BA: butyl methacrylate

MMA: methyl methacrylate,

AA: acrylic acid,

EA: ethyl acrylate,

AAEM: acetoacetoxyethyl methacrylate

AMA: allyl methacrylate

TMPTA: trimethylolpropane triacrylate

APS: Ammonium Persulfate

<Example 1>

In a 3 liter glass reactor equipped with an alcohol thermometer, stirrer, dripping burette, nitrogen inlet tube and reflux condenser, emulsify with the following composition at a reaction temperature of 84° C. did.

As a reactive anionic surfactant, 15 g of DKS's Hitenol KH-10 was added, 455 g of distilled water was added, and after sufficient stirring, 600 g of BA, 400 g of 2-EHA, 250 g of MMA, 200 g of EA, 15 g of AAEM, and 25 g of AA were added. An acrylic copolymer was prepared. In addition, 3g of KAO's E-118B and 500g of distilled water were added to the reactor. 2 to 5% by weight of the total pre-aqueous acrylic copolymer was first added, and 3 g of APS was added to 50 g of distilled water and the initial reaction was carried out for 0.5 hours. Subsequently, 40 g of distilled water and the remaining amount of the free aqueous acrylic copolymer were added dropwise to 5.3 g of APS for 4 hours.

After aging for 3 hours, after confirming the unreacted odor, the reaction was terminated.

<Example 2>

As a reactive anionic surfactant, 15g of DKS's Hitenol KH-10 was added, 455g of distilled water was added, and after sufficient stirring, 600g of BA, 400g of 2-EHA, 250g of MMA, 200g of EA, 15g of AMA, 25g of AA were added. An acrylic copolymer was prepared. In addition, 3g of KAO's E-118B and 500g of distilled water were added to the reactor. 2 to 5% by weight of the total pre-aqueous acrylic copolymer was first added, and 3 g of APS was added to 50 g of distilled water and the initial reaction was carried out for 0.5 hours. Afterwards, 40 g of distilled water and the remaining amount of the free aqueous acrylic copolymer were added dropwise to 5.3 g of APS for 4 hours.

<Example 3>

As an anionic surfactant, 40 g of KAO's E-118B is added, 455 g of distilled water is added, and after sufficient stirring, 600 g of BA, 400 g of 2-EHA, 250 g of MMA, 200 g of EA, 15 g of AAEM, and 25 g of AA are added. made a composite. In addition, 3g of KAO's E-118B and 500g of distilled water were added to the reactor. 2 to 5% by weight of the total pre-aqueous acrylic copolymer was first added, and 3 g of APS was added to 50 g of distilled water and the initial reaction was carried out for 0.5 hours. Subsequently, 40 g of distilled water and the remaining amount of the free aqueous acrylic copolymer were added dropwise to 5.3 g of APS for 4 hours.

<Example 4>

Surfactant uses a general anionic type, 30 g of DS-4 from SOLVAY, 455 g of distilled water, and after sufficient stirring, 600 g of BA, 400 g of 2-EHA, 250 g of MMA, 200 g of EA, 15 g of AAEM, and 25 g of AA are added, and after sufficient stirring, free An aqueous acrylic copolymer was prepared. In addition, 3g of KAO's E-118B and 500g of distilled water were added to the reactor. 2 to 5% by weight of the total pre-aqueous acrylic copolymer was first added, and 3 g of APS was added to 50 g of distilled water and the initial reaction was carried out for 0.5 hours. Subsequently, 40 g of distilled water and the remaining amount of the free aqueous acrylic copolymer were added dropwise to 5.3 g of APS for 4 hours.

<Example 5>

It was synthesized in the same manner except for the initial reaction in Example 1.

<Example 6>

Under the same conditions as in Example 1, 40 g of DKS's Hitenol KH-10 was added as a reactive anionic surfactant, 455 g of distilled water was added, and after sufficient stirring, BA 600 g, 2-EHA 400 g, MMA 250 g, EA 200 g, TMPTA 15 g, AA 25 g After sufficient stirring, a free aqueous acrylic copolymer was prepared. In addition, 3g of KAO's E-118B and 500g of distilled water were added to the reactor. 2 to 5% by weight of the total pre-aqueous acrylic copolymer was first added, and 3 g of APS was added to 50 g of distilled water and the initial reaction was carried out for 0.5 hours. Afterwards, 40 g of distilled water and the remaining amount of the free aqueous acrylic copolymer were added dropwise to 4.3 g of APS for 4 hours.

<Example 7>

For the surfactant, 15 g of ADEKA's SR-10 is added as a reactive anionic system, 455 g of distilled water is added, and after sufficient stirring, 600 g of BA, 400 g of 2-EHA, 250 g of MMA, 200 g of EA, 15 g of AAEM, and 25 g of AA are added. A copolymer was made. In addition, 3g of KAO's E-118B and 1500g of distilled water were added to the reactor. 2 to 5% by weight of the total pre-aqueous acrylic copolymer was first added, and 3 g of APS was added to 50 g of distilled water and the initial reaction was carried out for 0.5 hours. Subsequently, 40 g of distilled water and the remaining amount of the free aqueous acrylic copolymer were added dropwise to 5.3 g of APS for 4 hours.

<Example 8>

In Example 1, 15 g of the reactive surfactant KH-10 was added, reduced to 5 g, and the rest was synthesized in the same manner.

<Example 9>

It was synthesized in the same manner except for the initial reaction in Example 7.

<Comparative Example 1>

Organic solvent-type medical adhesives currently on the market

In case of basic physical property test

1) The solid content was dried in a dry oven at 145 ℃ for 40 minutes and then weighed.

2) Viscosity was measured three times using a brookfield LV Viscometer and expressed as an average.

3) For pH, it was measured once using a Metrohm pH meter.

4) Coating properties:

(1) Coating method: release paper (150mm X 300mm)

After dry 20 μm transfer coating (dried at 110°C for 3 minutes), 1 day aging of the close-fitting paper

(2) Coatability (5 to 1): 5: Good

4: Observation of 2 pinholes

3: Observe 2 to 4 pinholes

2: Observe 5 to 8 pinholes

1: More than 9 pinholes

(3) Substrate bonding strength: After making the coated specimen 50 mm x 50 mm, remove the release paper, fold the half so that the adhesive sides stick to each other, and then pin it again (repeat 10 times, check the peeled area), out of the total area The peeled portion was expressed as %.

In case of adhesive properties

1) Peel strength

After cutting to a predetermined size, peel the release paper, attach it to a stainless steel plate (SUS.304, polished with Sand Paper #280) in a constant temperature and humidity room, and press it back and forth once with a 2 kg compression roller.

After 20 minutes and 1 hour of compression, the peel strength is measured in a tensile tester, respectively. (180 peel)

① Test material; Polyester Film (25 ㎛) / Stainless Steel Plate

② Tensile distance; 300 mm/min

③ Adhesion area ; 25 mm × 40 mm or more

④ Weight and speed of crimping roll; 2 kg, 300 mm/min, 1 round trip

2) Retention (cohesion of the adhesive itself)

The test piece is 25 mm wide and 55 mm long, and the test piece is attached to a stainless plate so that an area of 25 mm wide and 25 mm long is attached. Press the test piece with a pressing roll from the top of the test piece, leave it in a constant temperature and humidity room for 1 hour, and then leave it in an environment of 60 ℃. left for 20 minutes at Then, apply a static load of 1 kg to the bottom and measure the time until the adhesive surface falls.

① Test material; Polyester Film (25 ㎛) / Stainless Steel Plate

② Measured temperature ; 60 ℃

③ Fixed load; 1 kg

④ Adhesive area ; 25 mm × 25 mm

⑤ measurement time; Time to fall after 60 minutes

⑥ Weight and speed of the crimping roll; 2 kg, 300 mm/min, 1 round trip

3) Initial Adhesion (Ball Tack)

In accordance with the J.DOW law, the stopped Ball No. is displayed.

① Test material; Polyester film (25㎛) / stainless steel plate

② Measurement conditions; 23±2 ℃, 50±5% RH

③ escape distance ; 50 mm

④ angle ; 30˚

⑤ Application amount; 25 ~ 30 μm

4) Particle size and particle distribution (PdI): using Malvern particle size analyzer

[Table 1]

As a result of carrying out the skin irritation test for rabbits in Example 5 according to the GLP standard (2.5 X 2.5 cm ² ), the mortality rate for 72 hours after applying the test substance to the back for 24 hours, general No abnormal symptoms were observed for symptoms, weight change, and skin irritation. According to Draize's evaluation method, the primary skin irritation index (PII) was calculated as “0.0” and was judged to be a non-irritating substance.

Claims (10)

A public comprising a structural unit derived from one or two or more (meth)acrylic acid ester monomers (A), a structural unit derived from the crosslinkability imparting monomer (B), and a structural unit derived from a functional monomer (C) coalescence;
Surfactants;
and water; comprising,
An aqueous pressure-sensitive adhesive composition comprising:
The viscosity of the composition is in the range of 4,000 to 6,000 cps,
The copolymer has a solid content of 50 to 60% by weight, an aqueous pressure-sensitive adhesive composition. According to claim 1, wherein the monomer (A) is butyl (meth) acrylate, t-butyl (meth) acrylate, 2-ethylhexyl (meth) acrylate, i-octyl (meth) acrylate, n- One or two or more monomers selected from the group consisting of octyl (meth) acrylate, ethyl (meth) acrylate, methyl (meth) acrylate, n-propyl (meth) acrylate and i-propyl (meth) acrylate Characterized in that, the aqueous pressure-sensitive adhesive composition. According to claim 1, wherein the monomer (C) is tridecyl acrylate, stearyl acrylate, trimethylolpropane triacrylate, 2-hydroxypropyl (meth) acrylate, 2-hydroxyethyl (meth) acrylic Late, diacetone acrylamide, trimethylolpropane tri(meth)acrylate (TMPTA), acetoacetoxyethyl (meth)acrylate, allyl (meth)acrylate, diethyl glycol diacrylate, 1,6-hexanediol An aqueous pressure-sensitive adhesive composition, characterized in that at least one selected from the group consisting of diacrylate and tripropylene glycol diacrylate (TPGDA). The aqueous pressure-sensitive adhesive composition according to claim 1, wherein the copolymer contains 0.1 to 10 parts by weight of the monomer (C) based on 100 parts by weight of the copolymer. The aqueous pressure-sensitive adhesive composition according to claim 1, wherein the copolymer is in the form of particles having a particle diameter of 50 to 300 nm. According to claim 1, wherein the surfactant is polyethylene alkylphenol ester, ammonium sulfate, sodium lauryl sulfate, ammonium dodecyl benzene sulfonate, sulfosuccinate, sodium dioctyl sulfosuccinate, sulfuric acid ester salt, polyoxy ethylene alkyl ether, fatty acid sorbital ester, fatty acid diethanol amine, alkyl monoglyceryl ether, alkyl sulfate ester salt, alkyl polyoxyethylene sulfate, sodium polyoxyethylene alkyl ether sulfate and alpha olefin sulfonate. Characterized in the water-based pressure-sensitive adhesive composition. According to claim 1, wherein the surfactant is characterized in that it comprises 0.5 to 5 parts by weight based on 100 parts by weight of the copolymer, the aqueous pressure-sensitive adhesive composition. delete The aqueous adhesive composition according to any one of claims 1 to 7, wherein the composition is for a medical adhesive cloth. The adhesive sheet containing the aqueous adhesive composition in any one of Claims 1-7.

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