KR102231037B1 - An antibacterial and antifungal agent for building interior and a building interior comprising the same - Google Patents

Abstract

The present invention provides a novel functional antibacterial and antifungal, and an antimicrobial and antifungal building interior material containing the same, in particular, gypsum board, gypsum board base and wallpaper.

Description

An antibacterial and antifungal agent for building interior and a building interior comprising the same}

The present invention relates to a novel functional antibacterial and antifungal agent, and to a building interior material including the same, in particular, gypsum board, gypsum board base, and wallpaper.

It is not an exaggeration to say that research on functional additives (antibacterial, antifungal, etc.) for interior materials for construction in Korea is not systematically conducted. Since antibacterial and antifungal agents for interior materials for construction are used in people's living spaces, environmental safety must be ensured in the manufacturing process, and additives that secure human biosafety as a material applied to human living spaces must be used. However, as functional additives for antibacterial and antifungal (anti-fungal), which were added to the existing interior materials for construction, preservatives and insecticides (some of Thiram, Iso-Thiazoline, etc.) with strong raw material toxicity were used.

Therefore, there is a need to develop a material that is not harmful to the human body as an antibacterial and anti-fungal agent for interior materials for construction and has guaranteed environmental safety.

It is an object of the present invention to prevent the occurrence of harmful bacteria and mold in building materials, especially gypsum board, gypsum board base, and interior materials such as interior construction wallpaper by moisture in an undried state after building construction. It is to provide antibacterial and antifungal agents that are not harmful and have environmental safety guaranteed.

Another object of the present invention is that the antibacterial and antifungal agents of the present invention are applied, so that the occurrence of harmful bacteria and mold is suppressed even after building construction, especially in a subtropical climate area, rainy season, or when the occurrence of mold is easy due to high humidity such as underground layers. It is possible to provide antibacterial and antifungal gypsum board, gypsum board base and interior materials for construction such as wallpaper.

In order to achieve the above object, the present invention is potassium 2-biphenylate (Potassium 2-biphenylate: CAS NO. 90-43-7) to a potassium salt attached to 2-hydroxybiphenyl (2-Hydroxybiphenyl; CAS NO. 90-43-7) NO. 13707-65-8), Copper pyrithione (CAS NO. 154592-20-8), and 1,2-Benzisothiazol-3(2H)-one: CAS NO. 2634-33-5) provides a novel functional antibacterial and antifungal agent consisting of at least one selected from the group consisting of.

In addition, the present invention is made of a mixture of sodium pyrithione (Sodium pyrithione; CAS NO. 3811-73-2) and sodium 2-biphenylate (sodium 2-biphenylate; CAS NO. 132-27-4). , Antibacterial and antifungal agents with improved antibacterial and antifungal performance are provided. In the antibacterial and antifungal agent of the present invention comprising a mixture of sodium pyrithione and sodium 2-biphenylate, the mixing ratio of the sodium pyrithione and the sodium 2-biphenylate is a weight ratio, sodium pyrithione It is preferable that it is on:sodium 2-biphenylate = 1:2.5-3.0. If the mixing ratio is out of the range, it is not preferable because there is a possibility that a chemical reaction may occur with other additives added when preparing gypsum slurry and pulp slurry.

In the present invention, the antibacterial and antifungal agents may be used in the form of a hydrophilic compound, or may be used in the form of a salt of the compound in consideration of the convenience of work and the compatibility with the raw materials for construction materials to be applied. It is preferable to use antibacterial and antifungal agents with improved solubility.

In addition, in the present invention, the potassium 2-biphenylate, copper pyrithione, and 1,2-benzisothiazole may each be used alone, or may be used in combination of two or more, and other conventional antimicrobial agents and It can also be used in combination with an antifungal agent. In general, antibacterial and antifungal agents may have different origins of bacteria or fungi that are effective for each active ingredient, so it is possible to prevent the propagation of various types of bacteria and fungi by selecting and mixing antibacterial and antifungal agents. It becomes. For this reason, it is also possible to use each of the antibacterial and antifungal agents of the present invention alone, but preferably, the antibacterial and antifungal effects can be increased several times through an efficient combination than using alone. Existing antibacterial and antifungal components that can be used in combination with the antibacterial and antifungal agents of the present invention include sodium pyrithione (CAS NO. 3811-73-2), and sodium 2-biphenylate (sodium). 2-biphenylate; CAS NO. 132-27-4) may be exemplified, but is not limited thereto.

There is no particular limitation on a method of applying the antibacterial and antifungal agent of the present invention to a building interior material, and can be added and applied together at the step of introducing additives during the manufacturing process of the interior material. In addition, the formulation to be applied is not particularly limited.For example, in the manufacturing process of building interior materials such as gypsum board, gypsum board base and wallpaper, in order to uniformly disperse the antibacterial and antifungal agents in the interior material raw material composition or raw material slurry, water It is preferably applied as a liquid formulation that is easy to mix with. In this way, by the use of liquid antibacterial and antifungal agents, the antibacterial and antifungal agents are uniformly dispersed in the interior material composition for building interior material, the material slurry, or the material pulp slurry, and the antibacterial and antifungal agents are evenly distributed in the center of the interior material to be manufactured , Excellent stability, antibacterial and anti-fungal effects can last a long time. In addition, liquid antibacterial and anti-fungal agents can simplify the process such as mixing compared to the powder type, and have advantages such as cost reduction.

When the antibacterial and antifungal agent of the present invention is applied to an interior material for a building, the amount added may vary depending on the type and mixed composition of the antibacterial and antifungal agent, and the weight of the interior material raw material composition or raw material slurry or raw material pulp slurry As a basis, 0.001 to 2.0% by weight, preferably 0.005 to 1.5% by weight is suitable. If the amount is less than 0.001% by weight, antibacterial and antifungal effects may be insufficient, and if it exceeds 2% by weight, it is not quantitatively and economically preferable as a functional additive.

In the present invention, there is also provided a building interior material containing the antibacterial and anti-fungal agent of the present invention, in particular, gypsum board, gypsum board base, and wallpaper.

The antibacterial and antifungal interior material for construction according to the present invention, in particular gypsum board, gypsum board base and wallpaper, the antibacterial and antifungal agent of the present invention is added to gypsum slurry, gypsum board pulp slurry or wallpaper pulp slurry, respectively, and uniform After mixing by stirring at a stirring speed of 100 to 500 rpm/min for dispersion, it can be prepared as a final product according to a conventional manufacturing process.

In the manufacture of the antibacterial and antifungal building interior material of the present invention, in addition to the antibacterial and antifungal agent of the present invention, various additives for each function commonly added when manufacturing each product can be used without limitation. For example, in the case of gypsum board, additives such as a hardening agent, a dispersant, and a water reducing agent may be used.

According to the present invention, by containing a novel antibacterial and anti-fungal functional component, it is possible to provide an interior material for construction such as gypsum board, gypsum board base, and wallpaper that can effectively suppress harmful bacteria and mold for a long period of time and stably. In addition, in the case of applying the antibacterial and antifungal agent of the present invention, it is possible to shorten the working time as it is possible to shorten the working time since there is no need for ancillary work to impart antibacterial and antifungal properties after construction of the interior material for construction. Can also be obtained.

1 is a photograph showing the results of Test Example 1 of the present invention.
2 is a photograph showing the results for Example 9 in Test Example 4 of the present invention.

The present invention is described in more detail through the following examples and comparative examples, but the following examples are for illustration only, and that the scope of the present invention is not limited by these examples to those of ordinary skill in the art. It will be self-evident.

[ Example And Comparative example ]

The types of antibacterial and antifungal agents used in the following Examples and Comparative Examples are shown in Table 1 below, and the antibacterial and antifungal composition of each Example and Comparative Example are shown in Table 2 below.

Abbreviation Antibacterial and antifungal agent Chemical name constitutional formula

K-OPP
Potassium
2-biphenylate

CuPT
Copper pyrithione

Na-OPP

Sodium
2-biphenylate

　

BIT

1,2-benzisothiazole

NPT
Sodium pyrithione

　

Antibacterial and antifungal agent Additive amount of active ingredient
(In 1kg gypsum board) Reference Example 1 K-OPP 30mg Reference Example 2 CuPT 30mg Reference Example 3 K-OPP + Na-OPP mixture 20mg+20mg Reference Example 4 CuPT + Na-OPP mixture 20mg+20mg Reference Example 5 K-OPP + NPT mixture 20mg+20mg Reference Example 6 CuPT + NPT mixture 20mg+20mg Reference Example 7 K-OPP + Na-OPP + NPT mixture 10mg+10mg+10mg Reference Example 8 CuPT + Na-OPP + NPT mixture 10mg+10mg+10mg Example 9 Na-OPP + NPT mixture 20mg+20mg Comparative Example 1 No additives - Comparative Example 2 NPT 30mg Comparative Example 3 Na-OPP 30mg

Test example One

To investigate the antifungal activity of Na-OPP, NPT and mixtures thereof, Murray P. R., Baron E. J., Pfaller M.A., Tenover F. C., and Yolke R.H. (1999), Manual of clinical microbiology, 7th. ed. ASM, Washington, DC. Antifungal activity analysis was performed according to the method.

Aspergillus Niger (ATCC 9642), Penicillium pinophilus (ATCC 11797), Chaetomium globosomes (ATCC 6205) and one fungus isolated from gypsum board were subcultured, A fungal spore suspension was prepared according to '2013-13 Disinfectant Efficacy Test of Mold', and then uniformly applied to a PDA (potato dextrose agar) medium. In order to measure the anti-fungal power, the antibacterial and anti-fungal agents of Example 9 and Comparative Examples 1 to 3 were dropped onto a sterilized paper disc (diameter 5 mm, Advantec, Japan) by 20 µl each, followed by air drying. , After incubation at 30°C, the generated inhibitory ring was measured. Measurement of anti-fungal efficacy was quantified as inhibitory ring and resistance. The inhibitory ring is the size (distance between the paper disk and the mold; mm) of a round strip-shaped clear zone that prevents mold from forming on the edge of the paper disk. Resistance was expressed as a numerical value of the extent (area) of mold growth on the surface of a paper disk, and the lower the value, the better the mold resistance (0: 0%, 1: 10%, 2: 10 to 30). %, 3: 30 to 60%, 4: 60% to total area). The observation results for each mold type are shown in Tables 3, 4, 5, and 6 below.

Antifungal efficacy against Aspergillus Niger (ATCC 9642) Antibacterial and antifungal agents added amount
(In 1kg gypsum board) sample Hae-hwan Resistance 200mg Example 9 10 0 Comparative Example 1 0 4 Comparative Example 2 2 0 Comparative Example 3 One 0 100mg Example 9 2.5 0 Comparative Example 1 0 4 Comparative Example 2 One 0 Comparative Example 3 0 0 44mg Example 9 One 0 Comparative Example 1 0 4 Comparative Example 2 0 0 Comparative Example 3 0 0 20mg Example 9 0.5 0 Comparative Example 1 0 4 Comparative Example 2 0 One Comparative Example 3 0 One

Antifungal efficacy against Penicillium pinophilus (ATCC 11797) Antibacterial and antifungal agents added amount
(In 1kg gypsum board) sample Hae-hwan Resistance 200mg Example 9 12 0 Comparative Example 1 0 4 Comparative Example 2 2 0 Comparative Example 3 2 0 100mg Example 9 2 0 Comparative Example 1 0 4 Comparative Example 2 One 0 Comparative Example 3 0 0 44mg Example 9 2 0 Comparative Example 1 0 4 Comparative Example 2 0.5 0 Comparative Example 3 0 One 20mg Example 9 2 0 Comparative Example 1 0 4 Comparative Example 2 0.5 0 Comparative Example 3 0 2

Antifungal efficacy against Chaetomium globosomes (ATCC 6205) Antibacterial and antifungal agents added amount
(In 1kg gypsum board) sample Hae-hwan Resistance 200mg Example 9 9 0 Comparative Example 1 0 4 Comparative Example 2 1.5 0 Comparative Example 3 One 0 100mg Example 9 5 0 Comparative Example 1 0 4 Comparative Example 2 One 0 Comparative Example 3 One 0 44mg Example 9 2.5 0 Comparative Example 1 0 4 Comparative Example 2 0.5 0 Comparative Example 3 0 2 20mg Example 9 One 0 Comparative Example 1 0 4 Comparative Example 2 0 One Comparative Example 3 0 One

Anti-fungal effect against mold separated from gypsum board Antibacterial and antifungal agents added amount
(In 1kg gypsum board) sample Hae-hwan Resistance 200mg Example 9 3.5 0 Comparative Example 1 0 4 Comparative Example 2 0 0 Comparative Example 3 1.5 0 100mg Example 9 2 0 Comparative Example 1 0 4 Comparative Example 2 One 0 Comparative Example 3 0.5 0 44mg Example 9 One 0 Comparative Example 1 0 4 Comparative Example 2 0 One Comparative Example 3 0 2 20mg Example 9 One 0 Comparative Example 1 0 4 Comparative Example 2 0 2 Comparative Example 3 0 3

Test example 2

In order to investigate the minimum inhibitory concentration (MIC) of Na-OPP, NPT, and mixtures thereof, Pfaller M A; Boyken L; Hollis R J; | Journal of clinical microbiology v.47 no.10, pp.3323-3325, 2009 was carried out according to the method.

In sterilized RPMI 1640 broth medium, 4 kinds of fungal spore suspensions and the antibacterial and antifungal agents of Example 9 and Comparative Examples 1 to 3 were added at each concentration, and after incubation at 30° C. for 2 to 3 days, 50% or more The concentration representing the mortality rate was determined as MIC. Synergism Index (SI) was F. C Kull, P. C. Eisman, H. D. Sylwestrowicz, R. L. Mayer; Calculated according to Applied Microbiology 9, 538-541, 1961 method.

As a result of the test, it was confirmed that when a mixture of Na-OPP and NPT was used, a significantly improved effect could be obtained than the simple summation of the effects of using each of them alone.

Test example 3

To prepare a gypsum board test piece by applying the antibacterial and anti-fungal agents of each Example and Comparative Example, and to test the anti-fungal effect, the test piece was placed in an incubator with a humidity of 95% and a temperature of 35°C in consideration of the rainy season in the summer when the climatic conditions were the worst. Into the gypsum board surface, the results of observing the occurrence of mold over time are shown in Table 8 below.

Mold outbreak date Mold outbreak situation 1 week 2 weeks 3 weeks 4 weeks 5 weeks Reference Example 1 11th 0 One One One 2 Reference Example 2 18 0 0 One One One Reference Example 3 24th 0 0 0 One One Reference Example 4 Not occurring 0 0 0 0 0 Reference Example 5 25 days 0 0 0 One One Reference Example 6 30 days 0 0 0 0 One Reference Example 7 Not occurring 0 0 0 0 0 Reference Example 8 Not occurring 0 0 0 0 0 Example 9 Not occurring 0 0 0 0 0 Comparative Example 1 2 days One 2 4 4 4 Comparative Example 2 10 days 0 One One One One Comparative Example 3 9 days 0 One One 2 2

(Note) Criteria for determining the mold outbreak situation

0: No mold occurs

1: Less than 1/4 of the mold area

2: mold area 1/4 ~ 2/4

3: Mold area 2/4 ~ 3/4

2: More than 3/4 of the mold area

Test example 4

A gypsum board test piece was prepared by applying the antibacterial and antifungal agents of each of the Examples and Comparative Examples, and the test was conducted for 4 weeks by a test method based on ASTM G21 “Procedure for measuring resistance to fungi of synthetic polymer materials”. Fungal species are Aspergillus Niger (ATCC 9642), Penicillium pinophilus (ATCC 11797), Glycladium Virence (ATCC 9645), Coetonium Globocium (ATCC 6205), Oreobashidium Five kinds of pullulans (ATCC 15233) were mixed and tested. The observation results after 4 weeks are shown in Table 9 below.

1 week 2 weeks 3 weeks 4 weeks Resistance Hae-hwan Resistance Hae-hwan Resistance Hae-hwan Resistance Hae-hwan Reference Example 1 0 7 0 5 0 4 0 0 Reference Example 2 0 10 0 7 0 0 0 0 Reference Example 3 0 10 0 10 0 9 0 8 Reference Example 4 0 13 0 13 0 13 0 10 Reference Example 5 0 13 0 11 0 10 0 8 Reference Example 6 0 15 0 15 0 14 0 10 Reference Example 7 0 15 0 15 0 15 0 13 Reference Example 8 0 20 0 20 0 20 0 18 Example 9 0 18 0 17 0 17 0 17 Comparative Example 1 4 0 4 0 4 0 4 0 Comparative Example 2 0 12 0 10 0 8 0 2 Comparative Example 3 0 11 0 5 0 2 0 0

(Note) Criteria for determining the mold outbreak situation

Resistance: The degree of mold growth (area) on the surface of the test piece is expressed as a number from 0 to 4, and the lower this value, the better the anti-mold effect.

(0: 0%, 1: 10%, 2: 10 to 30%, 3: 30 to 60%, 4: 60% to total area)

Hae-hwan: The size of the clear zone in the shape of a round strip that prevents mold from forming on the edge of the specimen (distance between the specimen and the mold; mm)

Claims (9)

As an antibacterial and antifungal agent for gypsum board consisting of a mixture of sodium pyrithione and sodium 2-biphenylate,
Antibacterial and antifungal agent for gypsum board, characterized in that when the amount of sodium pyrithione 20mg and sodium 2-biphenylate 20mg is added in 1kg of gypsum board, the inhibitory ring is 0.5 to 2mm, and the resistance is 0%.
(Here, the inhibitory ring is a round strip-shaped clear zone that prevents mold formed on the edge of the paper disc when cultured at 30° C. after air-drying by dropping 20 μl of the antibacterial and anti-fungal agent on a sterilized paper disc Indicate the size,
The resistance refers to the area where mold grows on the surface of the paper disk.) The antibacterial and antifungal agent for gypsum board according to claim 1, wherein the antibacterial and antifungal agent is in a liquid form. An interior material for construction, characterized in that it is a gypsum board or gypsum board base paper containing an antibacterial and anti-fungal agent for gypsum board according to claim 1 or 2. [4] The interior material for building according to claim 3, wherein the interior material for building contains 0.001 to 2.0% by weight of the antibacterial and antifungal agent for the gypsum board based on the weight of the interior material for building. The interior material for building according to claim 4, wherein the interior material for building contains 0.005 to 1.5% by weight of the antibacterial and antifungal agent for the gypsum board based on the weight of the interior material for building. The method of claim 3, wherein the building interior material is prepared by adding the antibacterial and antifungal agent for gypsum board to the building interior material composition or raw material slurry or raw material pulp slurry, and then stirring at a stirring speed of 100 to 500 rpm/min. Interior materials for construction, characterized by. delete delete delete

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