KR102227355B1 - Complex cosmetic composition for non-irritating weak acid exfoliation and epithelial cell nutrition - Google Patents
Complex cosmetic composition for non-irritating weak acid exfoliation and epithelial cell nutrition Download PDFInfo
- Publication number
- KR102227355B1 KR102227355B1 KR1020200096857A KR20200096857A KR102227355B1 KR 102227355 B1 KR102227355 B1 KR 102227355B1 KR 1020200096857 A KR1020200096857 A KR 1020200096857A KR 20200096857 A KR20200096857 A KR 20200096857A KR 102227355 B1 KR102227355 B1 KR 102227355B1
- Authority
- KR
- South Korea
- Prior art keywords
- weight
- parts
- skin
- cosmetic composition
- oil
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Expired - Fee Related
Links
- 239000000203 mixture Substances 0.000 title claims abstract description 76
- 239000002537 cosmetic Substances 0.000 title claims abstract description 64
- 235000016709 nutrition Nutrition 0.000 title abstract description 7
- 231100000344 non-irritating Toxicity 0.000 title abstract description 6
- 238000004299 exfoliation Methods 0.000 title abstract description 5
- 239000002253 acid Substances 0.000 title description 4
- 230000035764 nutrition Effects 0.000 title description 2
- 210000002919 epithelial cell Anatomy 0.000 title 1
- 230000000694 effects Effects 0.000 claims abstract description 43
- 206010000496 acne Diseases 0.000 claims abstract description 18
- 210000003491 skin Anatomy 0.000 claims description 80
- 235000019198 oils Nutrition 0.000 claims description 32
- 239000000284 extract Substances 0.000 claims description 24
- 229940061720 alpha hydroxy acid Drugs 0.000 claims description 23
- 150000001280 alpha hydroxy acids Chemical class 0.000 claims description 23
- 230000006872 improvement Effects 0.000 claims description 15
- 230000002087 whitening effect Effects 0.000 claims description 13
- IXIGWKNBFPKCCD-UHFFFAOYSA-N 2-hydroxy-5-octanoylbenzoic acid Chemical compound CCCCCCCC(=O)C1=CC=C(O)C(C(O)=O)=C1 IXIGWKNBFPKCCD-UHFFFAOYSA-N 0.000 claims description 12
- 240000004385 Centaurea cyanus Species 0.000 claims description 10
- 235000005940 Centaurea cyanus Nutrition 0.000 claims description 10
- 235000020238 sunflower seed Nutrition 0.000 claims description 9
- 244000179970 Monarda didyma Species 0.000 claims description 8
- 235000010672 Monarda didyma Nutrition 0.000 claims description 8
- 238000000034 method Methods 0.000 claims description 8
- 230000003020 moisturizing effect Effects 0.000 claims description 8
- 210000004927 skin cell Anatomy 0.000 claims description 8
- 240000004355 Borago officinalis Species 0.000 claims description 6
- 235000007689 Borago officinalis Nutrition 0.000 claims description 6
- 241001632576 Hyacinthus Species 0.000 claims description 6
- 244000042664 Matricaria chamomilla Species 0.000 claims description 6
- 235000007232 Matricaria chamomilla Nutrition 0.000 claims description 6
- 235000002911 Salvia sclarea Nutrition 0.000 claims description 6
- 244000182022 Salvia sclarea Species 0.000 claims description 6
- 230000037394 skin elasticity Effects 0.000 claims description 6
- 235000009024 Ceanothus sanguineus Nutrition 0.000 claims description 5
- 244000178870 Lavandula angustifolia Species 0.000 claims description 5
- 235000010663 Lavandula angustifolia Nutrition 0.000 claims description 5
- 240000003553 Leptospermum scoparium Species 0.000 claims description 5
- 235000015459 Lycium barbarum Nutrition 0.000 claims description 5
- 240000001910 Momordica cochinchinensis Species 0.000 claims description 5
- 235000009812 Momordica cochinchinensis Nutrition 0.000 claims description 5
- 244000270834 Myristica fragrans Species 0.000 claims description 5
- 235000009421 Myristica fragrans Nutrition 0.000 claims description 5
- 235000010841 Silybum marianum Nutrition 0.000 claims description 5
- 244000272459 Silybum marianum Species 0.000 claims description 5
- 235000009818 Trichosanthes kirilowii Nutrition 0.000 claims description 5
- 235000008995 european elder Nutrition 0.000 claims description 5
- 239000001102 lavandula vera Substances 0.000 claims description 5
- 235000018219 lavender Nutrition 0.000 claims description 5
- 239000001702 nutmeg Substances 0.000 claims description 5
- 239000001691 salvia sclarea Substances 0.000 claims description 5
- 244000003027 Bergamotto Species 0.000 claims description 4
- 235000007716 Citrus aurantium Nutrition 0.000 claims description 4
- 240000003791 Citrus myrtifolia Species 0.000 claims description 4
- 235000000228 Citrus myrtifolia Nutrition 0.000 claims description 4
- 235000016646 Citrus taiwanica Nutrition 0.000 claims description 4
- 241000366182 Melaleuca alternifolia Species 0.000 claims description 3
- 206010040844 Skin exfoliation Diseases 0.000 abstract description 18
- 230000002378 acidificating effect Effects 0.000 abstract description 2
- 230000003796 beauty Effects 0.000 abstract description 2
- 230000001747 exhibiting effect Effects 0.000 abstract description 2
- 230000000052 comparative effect Effects 0.000 description 36
- 239000003921 oil Substances 0.000 description 28
- LFQSCWFLJHTTHZ-UHFFFAOYSA-N Ethanol Chemical compound CCO LFQSCWFLJHTTHZ-UHFFFAOYSA-N 0.000 description 22
- DNIAPMSPPWPWGF-UHFFFAOYSA-N Propylene glycol Chemical compound CC(O)CO DNIAPMSPPWPWGF-UHFFFAOYSA-N 0.000 description 15
- 229930014626 natural product Natural products 0.000 description 15
- 238000012360 testing method Methods 0.000 description 13
- XLYOFNOQVPJJNP-UHFFFAOYSA-N water Substances O XLYOFNOQVPJJNP-UHFFFAOYSA-N 0.000 description 13
- 238000002360 preparation method Methods 0.000 description 11
- 239000002994 raw material Substances 0.000 description 11
- PEDCQBHIVMGVHV-UHFFFAOYSA-N Glycerol Natural products OCC(O)CO PEDCQBHIVMGVHV-UHFFFAOYSA-N 0.000 description 10
- 238000000605 extraction Methods 0.000 description 10
- 206010040880 Skin irritation Diseases 0.000 description 9
- -1 for example Substances 0.000 description 9
- 239000004615 ingredient Substances 0.000 description 9
- 230000036556 skin irritation Effects 0.000 description 9
- 231100000475 skin irritation Toxicity 0.000 description 9
- 239000002904 solvent Substances 0.000 description 8
- 238000009472 formulation Methods 0.000 description 7
- 230000007794 irritation Effects 0.000 description 7
- 239000000341 volatile oil Substances 0.000 description 7
- 206010012442 Dermatitis contact Diseases 0.000 description 6
- XEKOWRVHYACXOJ-UHFFFAOYSA-N Ethyl acetate Chemical compound CCOC(C)=O XEKOWRVHYACXOJ-UHFFFAOYSA-N 0.000 description 6
- VYPSYNLAJGMNEJ-UHFFFAOYSA-N Silicium dioxide Chemical compound O=[Si]=O VYPSYNLAJGMNEJ-UHFFFAOYSA-N 0.000 description 6
- HEMHJVSKTPXQMS-UHFFFAOYSA-M Sodium hydroxide Chemical compound [OH-].[Na+] HEMHJVSKTPXQMS-UHFFFAOYSA-M 0.000 description 6
- HVYWMOMLDIMFJA-DPAQBDIFSA-N cholesterol Chemical compound C1C=C2C[C@@H](O)CC[C@]2(C)[C@@H]2[C@@H]1[C@@H]1CC[C@H]([C@H](C)CCCC(C)C)[C@@]1(C)CC2 HVYWMOMLDIMFJA-DPAQBDIFSA-N 0.000 description 6
- 238000004519 manufacturing process Methods 0.000 description 6
- 239000000126 substance Substances 0.000 description 6
- 230000008859 change Effects 0.000 description 5
- 238000011156 evaluation Methods 0.000 description 5
- 235000011187 glycerol Nutrition 0.000 description 5
- 150000002632 lipids Chemical class 0.000 description 5
- 239000000843 powder Substances 0.000 description 5
- 238000011160 research Methods 0.000 description 5
- PUPZLCDOIYMWBV-UHFFFAOYSA-N (+/-)-1,3-Butanediol Chemical compound CC(O)CCO PUPZLCDOIYMWBV-UHFFFAOYSA-N 0.000 description 4
- YDNKGFDKKRUKPY-JHOUSYSJSA-N C16 ceramide Natural products CCCCCCCCCCCCCCCC(=O)N[C@@H](CO)[C@H](O)C=CCCCCCCCCCCCCC YDNKGFDKKRUKPY-JHOUSYSJSA-N 0.000 description 4
- 206010015150 Erythema Diseases 0.000 description 4
- AEMRFAOFKBGASW-UHFFFAOYSA-N Glycolic acid Chemical compound OCC(O)=O AEMRFAOFKBGASW-UHFFFAOYSA-N 0.000 description 4
- CRJGESKKUOMBCT-VQTJNVASSA-N N-acetylsphinganine Chemical compound CCCCCCCCCCCCCCC[C@@H](O)[C@H](CO)NC(C)=O CRJGESKKUOMBCT-VQTJNVASSA-N 0.000 description 4
- 229940106189 ceramide Drugs 0.000 description 4
- ZVEQCJWYRWKARO-UHFFFAOYSA-N ceramide Natural products CCCCCCCCCCCCCCC(O)C(=O)NC(CO)C(O)C=CCCC=C(C)CCCCCCCCC ZVEQCJWYRWKARO-UHFFFAOYSA-N 0.000 description 4
- 208000010247 contact dermatitis Diseases 0.000 description 4
- 239000006071 cream Substances 0.000 description 4
- 239000000839 emulsion Substances 0.000 description 4
- 210000002615 epidermis Anatomy 0.000 description 4
- JVTAAEKCZFNVCJ-UHFFFAOYSA-N lactic acid Chemical compound CC(O)C(O)=O JVTAAEKCZFNVCJ-UHFFFAOYSA-N 0.000 description 4
- 239000000463 material Substances 0.000 description 4
- VVGIYYKRAMHVLU-UHFFFAOYSA-N newbouldiamide Natural products CCCCCCCCCCCCCCCCCCCC(O)C(O)C(O)C(CO)NC(=O)CCCCCCCCCCCCCCCCC VVGIYYKRAMHVLU-UHFFFAOYSA-N 0.000 description 4
- 239000008213 purified water Substances 0.000 description 4
- 230000009257 reactivity Effects 0.000 description 4
- 238000000926 separation method Methods 0.000 description 4
- CSCPPACGZOOCGX-UHFFFAOYSA-N Acetone Chemical compound CC(C)=O CSCPPACGZOOCGX-UHFFFAOYSA-N 0.000 description 3
- HEDRZPFGACZZDS-UHFFFAOYSA-N Chloroform Chemical compound ClC(Cl)Cl HEDRZPFGACZZDS-UHFFFAOYSA-N 0.000 description 3
- YMWUJEATGCHHMB-UHFFFAOYSA-N Dichloromethane Chemical compound ClCCl YMWUJEATGCHHMB-UHFFFAOYSA-N 0.000 description 3
- KWYUFKZDYYNOTN-UHFFFAOYSA-M Potassium hydroxide Chemical compound [OH-].[K+] KWYUFKZDYYNOTN-UHFFFAOYSA-M 0.000 description 3
- 235000021355 Stearic acid Nutrition 0.000 description 3
- TVXBFESIOXBWNM-UHFFFAOYSA-N Xylitol Natural products OCCC(O)C(O)C(O)CCO TVXBFESIOXBWNM-UHFFFAOYSA-N 0.000 description 3
- 229940081733 cetearyl alcohol Drugs 0.000 description 3
- 239000003795 chemical substances by application Substances 0.000 description 3
- 235000012000 cholesterol Nutrition 0.000 description 3
- 230000003247 decreasing effect Effects 0.000 description 3
- 238000004821 distillation Methods 0.000 description 3
- 238000001035 drying Methods 0.000 description 3
- 238000002474 experimental method Methods 0.000 description 3
- 230000006870 function Effects 0.000 description 3
- 229930182478 glucoside Natural products 0.000 description 3
- UBHWBODXJBSFLH-UHFFFAOYSA-N hexadecan-1-ol;octadecan-1-ol Chemical compound CCCCCCCCCCCCCCCCO.CCCCCCCCCCCCCCCCCCO UBHWBODXJBSFLH-UHFFFAOYSA-N 0.000 description 3
- 210000002510 keratinocyte Anatomy 0.000 description 3
- 239000007788 liquid Substances 0.000 description 3
- 239000006210 lotion Substances 0.000 description 3
- HEBKCHPVOIAQTA-UHFFFAOYSA-N meso ribitol Natural products OCC(O)C(O)C(O)CO HEBKCHPVOIAQTA-UHFFFAOYSA-N 0.000 description 3
- VLKZOEOYAKHREP-UHFFFAOYSA-N n-Hexane Chemical compound CCCCCC VLKZOEOYAKHREP-UHFFFAOYSA-N 0.000 description 3
- QIQXTHQIDYTFRH-UHFFFAOYSA-N octadecanoic acid Chemical compound CCCCCCCCCCCCCCCCCC(O)=O QIQXTHQIDYTFRH-UHFFFAOYSA-N 0.000 description 3
- OQCDKBAXFALNLD-UHFFFAOYSA-N octadecanoic acid Natural products CCCCCCCC(C)CCCCCCCCC(O)=O OQCDKBAXFALNLD-UHFFFAOYSA-N 0.000 description 3
- 239000000523 sample Substances 0.000 description 3
- 239000000377 silicon dioxide Substances 0.000 description 3
- 230000008591 skin barrier function Effects 0.000 description 3
- 239000008117 stearic acid Substances 0.000 description 3
- 210000000434 stratum corneum Anatomy 0.000 description 3
- 235000015112 vegetable and seed oil Nutrition 0.000 description 3
- 239000000811 xylitol Substances 0.000 description 3
- 235000010447 xylitol Nutrition 0.000 description 3
- 229960002675 xylitol Drugs 0.000 description 3
- KZVAAIRBJJYZOW-VPENINKCSA-N (2r,3r,4s)-2-(hydroxymethyl)oxolane-3,4-diol Chemical compound OC[C@H]1OC[C@H](O)[C@H]1O KZVAAIRBJJYZOW-VPENINKCSA-N 0.000 description 2
- 229940015975 1,2-hexanediol Drugs 0.000 description 2
- VBICKXHEKHSIBG-UHFFFAOYSA-N 1-monostearoylglycerol Chemical compound CCCCCCCCCCCCCCCCCC(=O)OCC(O)CO VBICKXHEKHSIBG-UHFFFAOYSA-N 0.000 description 2
- IIZPXYDJLKNOIY-JXPKJXOSSA-N 1-palmitoyl-2-arachidonoyl-sn-glycero-3-phosphocholine Chemical class CCCCCCCCCCCCCCCC(=O)OC[C@H](COP([O-])(=O)OCC[N+](C)(C)C)OC(=O)CCC\C=C/C\C=C/C\C=C/C\C=C/CCCCC IIZPXYDJLKNOIY-JXPKJXOSSA-N 0.000 description 2
- NLMKTBGFQGKQEV-UHFFFAOYSA-N 2-[2-[2-[2-[2-[2-[2-[2-[2-[2-[2-[2-[2-[2-[2-[2-[2-[2-[2-(2-hexadecoxyethoxy)ethoxy]ethoxy]ethoxy]ethoxy]ethoxy]ethoxy]ethoxy]ethoxy]ethoxy]ethoxy]ethoxy]ethoxy]ethoxy]ethoxy]ethoxy]ethoxy]ethoxy]ethoxy]ethanol Chemical compound CCCCCCCCCCCCCCCCOCCOCCOCCOCCOCCOCCOCCOCCOCCOCCOCCOCCOCCOCCOCCOCCOCCOCCOCCOCCO NLMKTBGFQGKQEV-UHFFFAOYSA-N 0.000 description 2
- NCZPCONIKBICGS-UHFFFAOYSA-N 3-(2-ethylhexoxy)propane-1,2-diol Chemical compound CCCCC(CC)COCC(O)CO NCZPCONIKBICGS-UHFFFAOYSA-N 0.000 description 2
- RMTFNDVZYPHUEF-XZBKPIIZSA-N 3-O-methyl-D-glucose Chemical compound O=C[C@H](O)[C@@H](OC)[C@H](O)[C@H](O)CO RMTFNDVZYPHUEF-XZBKPIIZSA-N 0.000 description 2
- 229920000858 Cyclodextrin Polymers 0.000 description 2
- AERBNCYCJBRYDG-UHFFFAOYSA-N D-ribo-phytosphingosine Natural products CCCCCCCCCCCCCCC(O)C(O)C(N)CO AERBNCYCJBRYDG-UHFFFAOYSA-N 0.000 description 2
- 201000004624 Dermatitis Diseases 0.000 description 2
- RTZKZFJDLAIYFH-UHFFFAOYSA-N Diethyl ether Chemical compound CCOCC RTZKZFJDLAIYFH-UHFFFAOYSA-N 0.000 description 2
- LCGLNKUTAGEVQW-UHFFFAOYSA-N Dimethyl ether Chemical compound COC LCGLNKUTAGEVQW-UHFFFAOYSA-N 0.000 description 2
- WQZGKKKJIJFFOK-GASJEMHNSA-N Glucose Natural products OC[C@H]1OC(O)[C@H](O)[C@@H](O)[C@@H]1O WQZGKKKJIJFFOK-GASJEMHNSA-N 0.000 description 2
- 235000003222 Helianthus annuus Nutrition 0.000 description 2
- KFZMGEQAYNKOFK-UHFFFAOYSA-N Isopropanol Chemical compound CC(C)O KFZMGEQAYNKOFK-UHFFFAOYSA-N 0.000 description 2
- XUMBMVFBXHLACL-UHFFFAOYSA-N Melanin Chemical compound O=C1C(=O)C(C2=CNC3=C(C(C(=O)C4=C32)=O)C)=C2C4=CNC2=C1C XUMBMVFBXHLACL-UHFFFAOYSA-N 0.000 description 2
- KZTJQXAANJHSCE-OIDHKYIRSA-N N-octodecanoylsphinganine Chemical compound CCCCCCCCCCCCCCCCCC(=O)N[C@@H](CO)[C@H](O)CCCCCCCCCCCCCCC KZTJQXAANJHSCE-OIDHKYIRSA-N 0.000 description 2
- ATGQXSBKTQANOH-UWVGARPKSA-N N-oleoylphytosphingosine Chemical compound CCCCCCCCCCCCCC[C@@H](O)[C@@H](O)[C@H](CO)NC(=O)CCCCCCC\C=C/CCCCCCCC ATGQXSBKTQANOH-UWVGARPKSA-N 0.000 description 2
- 208000012641 Pigmentation disease Diseases 0.000 description 2
- 239000002202 Polyethylene glycol Substances 0.000 description 2
- ATUOYWHBWRKTHZ-UHFFFAOYSA-N Propane Chemical compound CCC ATUOYWHBWRKTHZ-UHFFFAOYSA-N 0.000 description 2
- HVUMOYIDDBPOLL-XWVZOOPGSA-N Sorbitan monostearate Chemical compound CCCCCCCCCCCCCCCCCC(=O)OC[C@@H](O)[C@H]1OC[C@H](O)[C@H]1O HVUMOYIDDBPOLL-XWVZOOPGSA-N 0.000 description 2
- XLOMVQKBTHCTTD-UHFFFAOYSA-N Zinc monoxide Chemical compound [Zn]=O XLOMVQKBTHCTTD-UHFFFAOYSA-N 0.000 description 2
- 239000004480 active ingredient Substances 0.000 description 2
- 239000000654 additive Substances 0.000 description 2
- 208000002029 allergic contact dermatitis Diseases 0.000 description 2
- 229940083987 anhydroxylitol Drugs 0.000 description 2
- 230000004888 barrier function Effects 0.000 description 2
- 239000000440 bentonite Substances 0.000 description 2
- 229910000278 bentonite Inorganic materials 0.000 description 2
- SVPXDRXYRYOSEX-UHFFFAOYSA-N bentoquatam Chemical compound O.O=[Si]=O.O=[Al]O[Al]=O SVPXDRXYRYOSEX-UHFFFAOYSA-N 0.000 description 2
- SESFRYSPDFLNCH-UHFFFAOYSA-N benzyl benzoate Chemical compound C=1C=CC=CC=1C(=O)OCC1=CC=CC=C1 SESFRYSPDFLNCH-UHFFFAOYSA-N 0.000 description 2
- WQZGKKKJIJFFOK-VFUOTHLCSA-N beta-D-glucose Chemical compound OC[C@H]1O[C@@H](O)[C@H](O)[C@@H](O)[C@@H]1O WQZGKKKJIJFFOK-VFUOTHLCSA-N 0.000 description 2
- 229940056318 ceteth-20 Drugs 0.000 description 2
- 229960001701 chloroform Drugs 0.000 description 2
- 229940107161 cholesterol Drugs 0.000 description 2
- 239000003086 colorant Substances 0.000 description 2
- 238000012790 confirmation Methods 0.000 description 2
- GHVNFZFCNZKVNT-UHFFFAOYSA-M decanoate Chemical compound CCCCCCCCCC([O-])=O GHVNFZFCNZKVNT-UHFFFAOYSA-M 0.000 description 2
- 239000007933 dermal patch Substances 0.000 description 2
- 235000014113 dietary fatty acids Nutrition 0.000 description 2
- 238000002481 ethanol extraction Methods 0.000 description 2
- 229940100524 ethylhexylglycerin Drugs 0.000 description 2
- 238000001704 evaporation Methods 0.000 description 2
- 239000000194 fatty acid Substances 0.000 description 2
- 229930195729 fatty acid Natural products 0.000 description 2
- 239000000499 gel Substances 0.000 description 2
- 239000008103 glucose Substances 0.000 description 2
- 229960001031 glucose Drugs 0.000 description 2
- 229940075529 glyceryl stearate Drugs 0.000 description 2
- 229960004275 glycolic acid Drugs 0.000 description 2
- 235000008216 herbs Nutrition 0.000 description 2
- FHKSXSQHXQEMOK-UHFFFAOYSA-N hexane-1,2-diol Chemical compound CCCCC(O)CO FHKSXSQHXQEMOK-UHFFFAOYSA-N 0.000 description 2
- 150000001261 hydroxy acids Chemical class 0.000 description 2
- 239000004310 lactic acid Substances 0.000 description 2
- 235000014655 lactic acid Nutrition 0.000 description 2
- 238000005259 measurement Methods 0.000 description 2
- 239000003595 mist Substances 0.000 description 2
- 235000015816 nutrient absorption Nutrition 0.000 description 2
- 239000002674 ointment Substances 0.000 description 2
- 210000000056 organ Anatomy 0.000 description 2
- 239000006072 paste Substances 0.000 description 2
- AERBNCYCJBRYDG-KSZLIROESA-N phytosphingosine Chemical compound CCCCCCCCCCCCCC[C@@H](O)[C@@H](O)[C@@H](N)CO AERBNCYCJBRYDG-KSZLIROESA-N 0.000 description 2
- 229940033329 phytosphingosine Drugs 0.000 description 2
- 229920001223 polyethylene glycol Polymers 0.000 description 2
- 230000008569 process Effects 0.000 description 2
- 229960004063 propylene glycol Drugs 0.000 description 2
- 238000000746 purification Methods 0.000 description 2
- 230000002829 reductive effect Effects 0.000 description 2
- 238000010992 reflux Methods 0.000 description 2
- HFHDHCJBZVLPGP-UHFFFAOYSA-N schardinger α-dextrin Chemical compound O1C(C(C2O)O)C(CO)OC2OC(C(C2O)O)C(CO)OC2OC(C(C2O)O)C(CO)OC2OC(C(O)C2O)C(CO)OC2OC(C(C2O)O)C(CO)OC2OC2C(O)C(O)C1OC2CO HFHDHCJBZVLPGP-UHFFFAOYSA-N 0.000 description 2
- 230000037307 sensitive skin Effects 0.000 description 2
- 230000037380 skin damage Effects 0.000 description 2
- 239000000344 soap Substances 0.000 description 2
- 229950011392 sorbitan stearate Drugs 0.000 description 2
- 239000007921 spray Substances 0.000 description 2
- PRAKJMSDJKAYCZ-UHFFFAOYSA-N squalane Chemical compound CC(C)CCCC(C)CCCC(C)CCCCC(C)CCCC(C)CCCC(C)C PRAKJMSDJKAYCZ-UHFFFAOYSA-N 0.000 description 2
- 229960004274 stearic acid Drugs 0.000 description 2
- 239000004094 surface-active agent Substances 0.000 description 2
- 239000000725 suspension Substances 0.000 description 2
- 239000000454 talc Substances 0.000 description 2
- 229910052623 talc Inorganic materials 0.000 description 2
- 238000005406 washing Methods 0.000 description 2
- 239000001993 wax Substances 0.000 description 2
- JNYAEWCLZODPBN-JGWLITMVSA-N (2r,3r,4s)-2-[(1r)-1,2-dihydroxyethyl]oxolane-3,4-diol Chemical compound OC[C@@H](O)[C@H]1OC[C@H](O)[C@H]1O JNYAEWCLZODPBN-JGWLITMVSA-N 0.000 description 1
- 229940058015 1,3-butylene glycol Drugs 0.000 description 1
- 229940043375 1,5-pentanediol Drugs 0.000 description 1
- WNWHHMBRJJOGFJ-UHFFFAOYSA-N 16-methylheptadecan-1-ol Chemical class CC(C)CCCCCCCCCCCCCCCO WNWHHMBRJJOGFJ-UHFFFAOYSA-N 0.000 description 1
- XDOFQFKRPWOURC-UHFFFAOYSA-N 16-methylheptadecanoic acid Chemical compound CC(C)CCCCCCCCCCCCCCC(O)=O XDOFQFKRPWOURC-UHFFFAOYSA-N 0.000 description 1
- UOQHWNPVNXSDDO-UHFFFAOYSA-N 3-bromoimidazo[1,2-a]pyridine-6-carbonitrile Chemical compound C1=CC(C#N)=CN2C(Br)=CN=C21 UOQHWNPVNXSDDO-UHFFFAOYSA-N 0.000 description 1
- 229920001817 Agar Polymers 0.000 description 1
- DKPFZGUDAPQIHT-UHFFFAOYSA-N Butyl acetate Natural products CCCCOC(C)=O DKPFZGUDAPQIHT-UHFFFAOYSA-N 0.000 description 1
- 241000132536 Cirsium Species 0.000 description 1
- FBPFZTCFMRRESA-FSIIMWSLSA-N D-Glucitol Natural products OC[C@H](O)[C@H](O)[C@@H](O)[C@H](O)CO FBPFZTCFMRRESA-FSIIMWSLSA-N 0.000 description 1
- 206010013786 Dry skin Diseases 0.000 description 1
- 206010014970 Ephelides Diseases 0.000 description 1
- 241000208818 Helianthus Species 0.000 description 1
- 244000020551 Helianthus annuus Species 0.000 description 1
- 102000001554 Hemoglobins Human genes 0.000 description 1
- 108010054147 Hemoglobins Proteins 0.000 description 1
- 241000282412 Homo Species 0.000 description 1
- UFHFLCQGNIYNRP-UHFFFAOYSA-N Hydrogen Chemical compound [H][H] UFHFLCQGNIYNRP-UHFFFAOYSA-N 0.000 description 1
- 206010061218 Inflammation Diseases 0.000 description 1
- 102000011782 Keratins Human genes 0.000 description 1
- 108010076876 Keratins Proteins 0.000 description 1
- GUBGYTABKSRVRQ-QKKXKWKRSA-N Lactose Natural products OC[C@H]1O[C@@H](O[C@H]2[C@H](O)[C@@H](O)C(O)O[C@@H]2CO)[C@H](O)[C@@H](O)[C@H]1O GUBGYTABKSRVRQ-QKKXKWKRSA-N 0.000 description 1
- UPYKUZBSLRQECL-UKMVMLAPSA-N Lycopene Natural products CC(=C/C=C/C=C(C)/C=C/C=C(C)/C=C/C1C(=C)CCCC1(C)C)C=CC=C(/C)C=CC2C(=C)CCCC2(C)C UPYKUZBSLRQECL-UKMVMLAPSA-N 0.000 description 1
- 208000003351 Melanosis Diseases 0.000 description 1
- 229920000168 Microcrystalline cellulose Polymers 0.000 description 1
- 239000004909 Moisturizer Substances 0.000 description 1
- BBAFBDLICMHBNU-MFZOPHKMSA-N N-(2-hydroxyoctadecanoyl)-4-hydroxysphinganine Chemical compound CCCCCCCCCCCCCCCCC(O)C(=O)N[C@@H](CO)[C@H](O)[C@H](O)CCCCCCCCCCCCCC BBAFBDLICMHBNU-MFZOPHKMSA-N 0.000 description 1
- 235000019502 Orange oil Nutrition 0.000 description 1
- OQILCOQZDHPEAZ-UHFFFAOYSA-N Palmitinsaeure-octylester Natural products CCCCCCCCCCCCCCCC(=O)OCCCCCCCC OQILCOQZDHPEAZ-UHFFFAOYSA-N 0.000 description 1
- 235000019483 Peanut oil Nutrition 0.000 description 1
- 229920003171 Poly (ethylene oxide) Polymers 0.000 description 1
- 239000004952 Polyamide Substances 0.000 description 1
- 241001558929 Sclerotium <basidiomycota> Species 0.000 description 1
- 244000044822 Simmondsia californica Species 0.000 description 1
- 235000004433 Simmondsia californica Nutrition 0.000 description 1
- 206010040914 Skin reaction Diseases 0.000 description 1
- 229920002472 Starch Polymers 0.000 description 1
- 230000006750 UV protection Effects 0.000 description 1
- 240000008042 Zea mays Species 0.000 description 1
- 235000005824 Zea mays ssp. parviglumis Nutrition 0.000 description 1
- 235000002017 Zea mays subsp mays Nutrition 0.000 description 1
- 239000013543 active substance Substances 0.000 description 1
- 239000008272 agar Substances 0.000 description 1
- 150000001298 alcohols Chemical class 0.000 description 1
- XAGFODPZIPBFFR-UHFFFAOYSA-N aluminium Chemical compound [Al] XAGFODPZIPBFFR-UHFFFAOYSA-N 0.000 description 1
- 229910052782 aluminium Inorganic materials 0.000 description 1
- WNROFYMDJYEPJX-UHFFFAOYSA-K aluminium hydroxide Chemical compound [OH-].[OH-].[OH-].[Al+3] WNROFYMDJYEPJX-UHFFFAOYSA-K 0.000 description 1
- 235000011126 aluminium potassium sulphate Nutrition 0.000 description 1
- 239000010775 animal oil Substances 0.000 description 1
- 230000002421 anti-septic effect Effects 0.000 description 1
- 239000000427 antigen Substances 0.000 description 1
- 102000036639 antigens Human genes 0.000 description 1
- 108091007433 antigens Proteins 0.000 description 1
- 239000002585 base Substances 0.000 description 1
- 238000003287 bathing Methods 0.000 description 1
- 230000009286 beneficial effect Effects 0.000 description 1
- 229960002903 benzyl benzoate Drugs 0.000 description 1
- 238000005282 brightening Methods 0.000 description 1
- 239000001273 butane Substances 0.000 description 1
- 235000019437 butane-1,3-diol Nutrition 0.000 description 1
- 239000000378 calcium silicate Substances 0.000 description 1
- 229910052918 calcium silicate Inorganic materials 0.000 description 1
- OYACROKNLOSFPA-UHFFFAOYSA-N calcium;dioxido(oxo)silane Chemical compound [Ca+2].[O-][Si]([O-])=O OYACROKNLOSFPA-UHFFFAOYSA-N 0.000 description 1
- 125000004432 carbon atom Chemical group C* 0.000 description 1
- 150000001746 carotenes Chemical class 0.000 description 1
- 235000005473 carotenes Nutrition 0.000 description 1
- 239000000969 carrier Substances 0.000 description 1
- 239000004359 castor oil Substances 0.000 description 1
- 235000019438 castor oil Nutrition 0.000 description 1
- 239000001913 cellulose Substances 0.000 description 1
- 235000010980 cellulose Nutrition 0.000 description 1
- 229920002678 cellulose Polymers 0.000 description 1
- 239000002738 chelating agent Substances 0.000 description 1
- 238000004587 chromatography analysis Methods 0.000 description 1
- 239000001926 citrus aurantium l. subsp. bergamia wright et arn. oil Substances 0.000 description 1
- 239000011248 coating agent Substances 0.000 description 1
- 238000000576 coating method Methods 0.000 description 1
- 239000000306 component Substances 0.000 description 1
- 238000007906 compression Methods 0.000 description 1
- 230000006835 compression Effects 0.000 description 1
- 238000011109 contamination Methods 0.000 description 1
- 238000007796 conventional method Methods 0.000 description 1
- 239000000498 cooling water Substances 0.000 description 1
- 235000005822 corn Nutrition 0.000 description 1
- 210000000736 corneocyte Anatomy 0.000 description 1
- 239000008406 cosmetic ingredient Substances 0.000 description 1
- 235000012343 cottonseed oil Nutrition 0.000 description 1
- 239000002385 cottonseed oil Substances 0.000 description 1
- 230000002354 daily effect Effects 0.000 description 1
- 210000004207 dermis Anatomy 0.000 description 1
- 239000003599 detergent Substances 0.000 description 1
- 238000011161 development Methods 0.000 description 1
- 230000004069 differentiation Effects 0.000 description 1
- 239000003085 diluting agent Substances 0.000 description 1
- 230000037336 dry skin Effects 0.000 description 1
- 239000003995 emulsifying agent Substances 0.000 description 1
- 210000001339 epidermal cell Anatomy 0.000 description 1
- 231100000321 erythema Toxicity 0.000 description 1
- 239000000686 essence Substances 0.000 description 1
- GJQLBGWSDGMZKM-UHFFFAOYSA-N ethylhexyl palmitate Chemical compound CCCCCCCCCCCCCCCC(=O)OC(CC)CCCCC GJQLBGWSDGMZKM-UHFFFAOYSA-N 0.000 description 1
- 230000008020 evaporation Effects 0.000 description 1
- 230000003203 everyday effect Effects 0.000 description 1
- 150000004665 fatty acids Chemical class 0.000 description 1
- 238000001914 filtration Methods 0.000 description 1
- 239000006260 foam Substances 0.000 description 1
- 239000003205 fragrance Substances 0.000 description 1
- 238000004108 freeze drying Methods 0.000 description 1
- 150000008131 glucosides Chemical class 0.000 description 1
- ZEMPKEQAKRGZGQ-XOQCFJPHSA-N glycerol triricinoleate Natural products CCCCCC[C@@H](O)CC=CCCCCCCCC(=O)OC[C@@H](COC(=O)CCCCCCCC=CC[C@@H](O)CCCCCC)OC(=O)CCCCCCCC=CC[C@H](O)CCCCCC ZEMPKEQAKRGZGQ-XOQCFJPHSA-N 0.000 description 1
- 239000008187 granular material Substances 0.000 description 1
- FUZZWVXGSFPDMH-UHFFFAOYSA-N hexanoic acid Chemical compound CCCCCC(O)=O FUZZWVXGSFPDMH-UHFFFAOYSA-N 0.000 description 1
- 125000002887 hydroxy group Chemical group [H]O* 0.000 description 1
- 230000004054 inflammatory process Effects 0.000 description 1
- 230000002401 inhibitory effect Effects 0.000 description 1
- 150000002500 ions Chemical class 0.000 description 1
- 239000002085 irritant Substances 0.000 description 1
- 231100000021 irritant Toxicity 0.000 description 1
- 208000001875 irritant dermatitis Diseases 0.000 description 1
- 229940099563 lactobionic acid Drugs 0.000 description 1
- 239000008101 lactose Substances 0.000 description 1
- 230000002045 lasting effect Effects 0.000 description 1
- 230000000670 limiting effect Effects 0.000 description 1
- 239000012528 membrane Substances 0.000 description 1
- 235000019813 microcrystalline cellulose Nutrition 0.000 description 1
- 239000008108 microcrystalline cellulose Substances 0.000 description 1
- 229940016286 microcrystalline cellulose Drugs 0.000 description 1
- 238000002156 mixing Methods 0.000 description 1
- 238000012986 modification Methods 0.000 description 1
- 230000004048 modification Effects 0.000 description 1
- 230000001333 moisturizer Effects 0.000 description 1
- CQDGTJPVBWZJAZ-UHFFFAOYSA-N monoethyl carbonate Chemical compound CCOC(O)=O CQDGTJPVBWZJAZ-UHFFFAOYSA-N 0.000 description 1
- JXTPJDDICSTXJX-UHFFFAOYSA-N n-Triacontane Natural products CCCCCCCCCCCCCCCCCCCCCCCCCCCCCC JXTPJDDICSTXJX-UHFFFAOYSA-N 0.000 description 1
- IJDNQMDRQITEOD-UHFFFAOYSA-N n-butane Chemical compound CCCC IJDNQMDRQITEOD-UHFFFAOYSA-N 0.000 description 1
- OFBQJSOFQDEBGM-UHFFFAOYSA-N n-pentane Natural products CCCCC OFBQJSOFQDEBGM-UHFFFAOYSA-N 0.000 description 1
- 235000015097 nutrients Nutrition 0.000 description 1
- WWZKQHOCKIZLMA-UHFFFAOYSA-N octanoic acid Chemical compound CCCCCCCC(O)=O WWZKQHOCKIZLMA-UHFFFAOYSA-N 0.000 description 1
- 239000004006 olive oil Substances 0.000 description 1
- 235000008390 olive oil Nutrition 0.000 description 1
- 239000010502 orange oil Substances 0.000 description 1
- 239000003960 organic solvent Substances 0.000 description 1
- 230000033116 oxidation-reduction process Effects 0.000 description 1
- 239000012188 paraffin wax Substances 0.000 description 1
- 239000000312 peanut oil Substances 0.000 description 1
- WCVRQHFDJLLWFE-UHFFFAOYSA-N pentane-1,2-diol Chemical compound CCCC(O)CO WCVRQHFDJLLWFE-UHFFFAOYSA-N 0.000 description 1
- 239000003208 petroleum Substances 0.000 description 1
- 239000000546 pharmaceutical excipient Substances 0.000 description 1
- WVDDGKGOMKODPV-ZQBYOMGUSA-N phenyl(114C)methanol Chemical compound O[14CH2]C1=CC=CC=C1 WVDDGKGOMKODPV-ZQBYOMGUSA-N 0.000 description 1
- 230000035790 physiological processes and functions Effects 0.000 description 1
- 230000019612 pigmentation Effects 0.000 description 1
- 229920002647 polyamide Polymers 0.000 description 1
- 229940100518 polyglyceryl-4 isostearate Drugs 0.000 description 1
- 229920001296 polysiloxane Polymers 0.000 description 1
- 229920000136 polysorbate Polymers 0.000 description 1
- 239000011148 porous material Substances 0.000 description 1
- 229940050271 potassium alum Drugs 0.000 description 1
- GRLPQNLYRHEGIJ-UHFFFAOYSA-J potassium aluminium sulfate Chemical compound [Al+3].[K+].[O-]S([O-])(=O)=O.[O-]S([O-])(=O)=O GRLPQNLYRHEGIJ-UHFFFAOYSA-J 0.000 description 1
- 239000003755 preservative agent Substances 0.000 description 1
- 230000002335 preservative effect Effects 0.000 description 1
- 239000001294 propane Substances 0.000 description 1
- 239000003380 propellant Substances 0.000 description 1
- 238000010298 pulverizing process Methods 0.000 description 1
- 238000012827 research and development Methods 0.000 description 1
- 230000004044 response Effects 0.000 description 1
- 230000000284 resting effect Effects 0.000 description 1
- 238000013077 scoring method Methods 0.000 description 1
- 210000002374 sebum Anatomy 0.000 description 1
- 239000008159 sesame oil Substances 0.000 description 1
- 235000011803 sesame oil Nutrition 0.000 description 1
- 230000035483 skin reaction Effects 0.000 description 1
- 231100000430 skin reaction Toxicity 0.000 description 1
- 230000036548 skin texture Effects 0.000 description 1
- 239000000600 sorbitol Substances 0.000 description 1
- 229940032094 squalane Drugs 0.000 description 1
- 239000008107 starch Substances 0.000 description 1
- 235000019698 starch Nutrition 0.000 description 1
- 210000004003 subcutaneous fat Anatomy 0.000 description 1
- 230000000475 sunscreen effect Effects 0.000 description 1
- 239000000516 sunscreening agent Substances 0.000 description 1
- 239000000375 suspending agent Substances 0.000 description 1
- 239000002562 thickening agent Substances 0.000 description 1
- 238000010415 tidying Methods 0.000 description 1
- 231100000331 toxic Toxicity 0.000 description 1
- 230000002588 toxic effect Effects 0.000 description 1
- LADGBHLMCUINGV-UHFFFAOYSA-N tricaprin Chemical compound CCCCCCCCCC(=O)OCC(OC(=O)CCCCCCCCC)COC(=O)CCCCCCCCC LADGBHLMCUINGV-UHFFFAOYSA-N 0.000 description 1
- 238000000108 ultra-filtration Methods 0.000 description 1
- 238000002137 ultrasound extraction Methods 0.000 description 1
- 239000008158 vegetable oil Substances 0.000 description 1
- NCYCYZXNIZJOKI-UHFFFAOYSA-N vitamin A aldehyde Natural products O=CC=C(C)C=CC=C(C)C=CC1=C(C)CCCC1(C)C NCYCYZXNIZJOKI-UHFFFAOYSA-N 0.000 description 1
- 238000003809 water extraction Methods 0.000 description 1
- 230000037303 wrinkles Effects 0.000 description 1
- HEBKCHPVOIAQTA-SCDXWVJYSA-N xylitol Chemical compound OC[C@H](O)[C@@H](O)[C@H](O)CO HEBKCHPVOIAQTA-SCDXWVJYSA-N 0.000 description 1
- 239000011787 zinc oxide Substances 0.000 description 1
- 210000000216 zygoma Anatomy 0.000 description 1
Images
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K8/00—Cosmetics or similar toiletry preparations
- A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
- A61K8/30—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds
- A61K8/33—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds containing oxygen
- A61K8/36—Carboxylic acids; Salts or anhydrides thereof
- A61K8/368—Carboxylic acids; Salts or anhydrides thereof with carboxyl groups directly bound to carbon atoms of aromatic rings
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K8/00—Cosmetics or similar toiletry preparations
- A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
- A61K8/30—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds
- A61K8/33—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds containing oxygen
- A61K8/36—Carboxylic acids; Salts or anhydrides thereof
- A61K8/365—Hydroxycarboxylic acids; Ketocarboxylic acids
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K8/00—Cosmetics or similar toiletry preparations
- A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
- A61K8/96—Cosmetics or similar toiletry preparations characterised by the composition containing materials, or derivatives thereof of undetermined constitution
- A61K8/97—Cosmetics or similar toiletry preparations characterised by the composition containing materials, or derivatives thereof of undetermined constitution from algae, fungi, lichens or plants; from derivatives thereof
- A61K8/9783—Angiosperms [Magnoliophyta]
- A61K8/9789—Magnoliopsida [dicotyledons]
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K8/00—Cosmetics or similar toiletry preparations
- A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
- A61K8/96—Cosmetics or similar toiletry preparations characterised by the composition containing materials, or derivatives thereof of undetermined constitution
- A61K8/97—Cosmetics or similar toiletry preparations characterised by the composition containing materials, or derivatives thereof of undetermined constitution from algae, fungi, lichens or plants; from derivatives thereof
- A61K8/9783—Angiosperms [Magnoliophyta]
- A61K8/9794—Liliopsida [monocotyledons]
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61Q—SPECIFIC USE OF COSMETICS OR SIMILAR TOILETRY PREPARATIONS
- A61Q19/00—Preparations for care of the skin
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K2800/00—Properties of cosmetic compositions or active ingredients thereof or formulation aids used therein and process related aspects
- A61K2800/20—Chemical, physico-chemical or functional or structural properties of the composition as a whole
- A61K2800/28—Rubbing or scrubbing compositions; Peeling or abrasive compositions; Containing exfoliants
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K2800/00—Properties of cosmetic compositions or active ingredients thereof or formulation aids used therein and process related aspects
- A61K2800/70—Biological properties of the composition as a whole
- A61K2800/72—Hypo-allergenic
Landscapes
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- General Health & Medical Sciences (AREA)
- Veterinary Medicine (AREA)
- Public Health (AREA)
- Animal Behavior & Ethology (AREA)
- Epidemiology (AREA)
- Birds (AREA)
- Emergency Medicine (AREA)
- Engineering & Computer Science (AREA)
- Biotechnology (AREA)
- Botany (AREA)
- Microbiology (AREA)
- Mycology (AREA)
- Dermatology (AREA)
- Cosmetics (AREA)
Abstract
본 발명은 비자극성 약산성 각질제거 및 영양공급 효과를 나타내는 화장료 조성물에 관한 것으로서, 상기 화장료 조성물은 피부 각질 제거 및 블랙헤드 케어와 동시에 피부 진정, 영양공급, 광채감 부여 및 피부 미용에 우수한 효과를 갖는 것을 특징으로 한다.The present invention relates to a cosmetic composition exhibiting a non-irritating weakly acidic exfoliation and nutritional supply effect, wherein the cosmetic composition has excellent effects on skin soothing, nutritional supply, radiance, and skin beauty at the same time as skin exfoliation and blackhead care. It is characterized by that.
Description
본 발명은 비자극성 약산성 각질제거 및 영양공급 효과를 나타내는 화장료 조성물에 관한 것으로서, 상기 화장료 조성물은 피부 각질 제거 및 블랙헤드 케어와 동시에 피부 진정, 영양공급, 광채감 부여 및 피부 미용에 우수한 효과를 갖는 것을 특징으로 한다.The present invention relates to a cosmetic composition exhibiting a non-irritating weakly acidic exfoliation and nutritional supply effect, wherein the cosmetic composition has excellent effects on skin soothing, nutritional supply, radiance, and skin beauty at the same time as skin exfoliation and blackhead care. It is characterized by that.
피부는 외부 자극으로부터 우리 몸의 여러 기관을 보호하고 있는 가장 큰 기관으로써, 다양한 생리적 역할을 담당하고 있다. 하지만 나이가 들면서 여러 가지 내적, 외적요인에 의하여 피부의 생리적기능과 장벽으로서의 기능이 저하되어, 외부의 작은 자극에 의하여서도 피부 손상이 쉽게 일어난다. 따라서 외부 자극에 의한 피부 손상을 경감시켜 주기 위하여 화장품 사용의 필요성이 대두되고 있다. The skin is the largest organ protecting various organs of our body from external stimuli, and plays various physiological roles. However, with age, the physiological function of the skin and its function as a barrier are deteriorated due to various internal and external factors, and skin damage is easily caused even by a small external stimulus. Therefore, the necessity of using cosmetics has emerged in order to alleviate skin damage caused by external stimuli.
오늘날 거의 모든 사람이 다양한 종류와 형태의 화장품을 사용하고 있고, 화장품 업계는 끊임없이 새로운 소재의 화장품을 연구 개발하는데 주력하고 있다. Today, almost everyone uses cosmetics of various types and forms, and the cosmetics industry is constantly focusing on research and development of cosmetics with new materials.
피부는 크게 표피, 진피, 피하지방조직의 3개 층으로 구성된다. 표피(epidermis)는 바깥쪽에서 안쪽으로 각질층, 투명층, 과립층, 기저층으로 나뉜다. 표피의 최외곽 층인 피부 각질층(stratum corneum)은 피부장벽 기능의 가장 중요한 구조로서, 무핵의 편평한 각질세포(corneocytes)와, 각질세포간 지질(SC intercellular lipid)로 이루어져 있다. 정상적인 표피세포의 분열 및 분화과정을 통해 유지되는 피부장벽의 각질세포가 합성하는 세라마이드, 콜레스테롤, 및 지방산과 같은 세포간 지질로 형성된 다층지질막(multi lamella lipid layer)은 피부 내의 수분이 증발하지 않도록 방어막 역할을 한다.The skin is largely composed of three layers: epidermis, dermis, and subcutaneous fat tissue. The epidermis is divided into a stratum corneum, a transparent layer, a granule layer, and a basal layer from the outside to the inside. The outermost layer of the epidermis, the stratum corneum, is the most important structure of the skin barrier function, and consists of nucleated flat corneocytes and SC intercellular lipids. A multi-lamella lipid layer formed of intercellular lipids such as ceramide, cholesterol, and fatty acids synthesized by keratinocytes of the skin barrier that is maintained through the process of division and differentiation of normal epidermal cells is a barrier to prevent moisture in the skin from evaporating. Plays a role.
피부 각질층의 각질세포 간에는 다양한 종류의 지질이 존재하고, 이러한 지질들은 각질세포 사이에 존재하여 피부 수분의 증발을 방지하고, 외부 자극이나 오염으로부터 피부를 보호하는 피부장벽의 기능을 한다.Various types of lipids exist between keratinocytes in the stratum corneum of the skin, and these lipids exist between keratinocytes to prevent evaporation of skin moisture and function as a skin barrier to protect the skin from external irritation or contamination.
화장품은 피부 청결, 보습, 자외선 차단, 주름 개선, 미백, 진정 등 피부에 이로운 기능을 갖지만 접촉 피부염의 주요 원인이 될 수 있다. 접촉 피부염(contact dermatitis)은 외부물질과 접촉하여 발생하는 피부염이며, 자극성 물질에 의한 자극성 접촉 피부염과 특정 항원에 감작된 사람에서 발생하는 알레르기성 접촉 피부염으로 분류된다. Cosmetics have beneficial functions for skin such as skin cleansing, moisturizing, UV protection, wrinkle improvement, whitening, and soothing, but can be a major cause of contact dermatitis. Contact dermatitis is dermatitis caused by contact with foreign substances, and is classified into irritant contact dermatitis caused by an irritant substance and allergic contact dermatitis that occurs in people sensitized to a specific antigen.
화장품에 의한 피부염은 사용자의 2% 미만에서 나타나고 있으며, 이중 알레르기성 접촉 피부염 은 화장품에 의한 부작용의 5~10%를 차지하며, 피부과를 방문하는 환자의 0.3~3% 정도로 보고되고 있다. 화장품은 다양한 성분들이 혼합되어 제조되고, 인체에 직접 접촉할 뿐 아니라 장기간 동안 사용되기 때문에 원료들의 안전성은 물론 화장품 자체의 안전성도 반드시 확보 되어야만 한다.Cosmetic dermatitis occurs in less than 2% of users, of which allergic contact dermatitis accounts for 5-10% of the side effects caused by cosmetics, and is reported to be about 0.3-3% of patients visiting dermatology. Cosmetics are manufactured by mixing various ingredients and not only directly contact the human body, but are used for a long period of time, so the safety of the ingredients as well as the cosmetics itself must be secured.
또한, 화장품 업계에서는 여러 화학물질 등에 의한 피부 자극을 줄이기 위해 천연물을 사용한 제품이 다수 개발되고 있다. 천연 재료는 피부에 부작용이 적을 뿐 아니라, 최근 천연 재료를 이용한 화장품에 대한 소비자들의 호응이 높아짐에 따라 화장품 원료로서 개발가치가 한층 늘어나고 있다.In addition, in the cosmetic industry, a number of products using natural products are being developed to reduce skin irritation caused by various chemical substances. Natural ingredients not only have fewer side effects on the skin, but recently, as consumers' response to cosmetics using natural ingredients has increased, the development value as a cosmetic ingredient is increasing even more.
이에 따라, 생체 안전성이 우수하고, 한 번에 여러가지 복합 효과를 가지면서도 인체에 전혀 무해한 화장품 제품의 개발 필요성이 꾸준히 대두되고 있는 상황이다.Accordingly, the necessity of developing cosmetic products that are excellent in biosafety and are completely harmless to the human body while having various complex effects at once is steadily emerging.
본 발명의 목적은 피부에 자극이 적은 각질제거 성분을 포함하고, 피부에 즉각적으로 영양을 공급할 수 있는 화장료 조성물 및 그 제조방법을 제공하는 것이다.It is an object of the present invention to provide a cosmetic composition comprising an exfoliating component that is less irritating to the skin and capable of immediately supplying nutrition to the skin, and a method for producing the same.
구체적으로, 상기 화장료 조성물은 피부 각질 제거, 블랙헤드 케어, 피부 진정, 피부결 정돈 및 영양공급의 효과를 갖는 화장료 조성물 및 그 제조방법을 제공하는 것이다. Specifically, the cosmetic composition is to provide a cosmetic composition having the effect of exfoliating the skin, care for blackheads, soothing the skin, tidying the skin texture and supplying nutrients, and a method for producing the same.
상기와 같은 목적을 달성하기 위한 본 발명의 일 측면은, 카프릴로일살리실릭애씨드(Capryloyl Salicylic Acid, LHA), 폴리-알파하이드록시애시드(PHA) 및 알파하이드록시애시드(AHA)로 구성된 필링 성분; 육두구(Nutmeg), 하늘타리(Chinese cucumber) 뿌리, 흰무늬엉겅퀴(Silybum marianum) 씨, 엘더플라워(Elder flower), 다마스크장미(Rosa Damascena) 꽃, 라벤더꽃, 클레리(Salvia Sclarea), 히아신스(Hyacinthus)전초, 마트리카리아(Matricaria chamomilla) 꽃, 보리지(Borago officinalis) 및 수레국화(Centaurea cyanus) 꽃으로 구성된 군에서 하나 이상 선택된 것을 포함하여 제조된 것인, 화장료 조성물을 제공한다.One aspect of the present invention for achieving the above object is a peeling component consisting of capryloyl salicylic acid (LHA), poly-alpha hydroxy acid (PHA) and alpha hydroxy acid (AHA) ; Nutmeg, Chinese cucumber root, Silybum marianum seed, Elder flower, Rosa Damascena flower, lavender flower, Salvia Sclarea , hyacinth ) Outpost, Matricaria chamomilla (Matricaria chamomilla) flowers, borage (Borago officinalis ) and cornflower ( Centaurea cyanus ) to provide a cosmetic composition comprising one or more selected from the group consisting of flowers.
구체적으로, 상기 화장료 조성물은 베르가못(citrus aurantium bergamia, bergamot) 오일, 티트리(Melaleuca alternifolia) 오일, 오렌지(Citrus Aurantium Dulcis) 오일 및 해바라기씨 오일로 구성된 군에서 하나 이상 선택된 것을 추가로 더 포함하여 제조된 것일 수 있으며, 더욱 구체적으로는 카프릴로일살리실릭애씨드(LHA) 1 중량부, 폴리-알파하이드록시애시드(PHA) 1 중량부 및 알파하이드록시애시드(AHA) 0.3 중량부, 육두구(Nutmeg) 20 내지 50 중량부, 하늘타리(Chinese cucumber) 뿌리 20 내지 50 중량부, 흰무늬엉겅퀴(Silybum marianum) 씨 10 내지 40 중량부, 엘더플라워(Elder flower) 10 내지 40 중량부, 다마스크장미(Rosa Damascena) 꽃 10 내지 30 중량부, 라벤더꽃 10 내지 30 중량부, 클레리(Salvia Sclarea) 10 내지 30 중량부, 히아신스(Hyacinthus) 전초 1 내지 30 중량부, 마트리카리아(Matricaria chamomilla) 꽃 1 내지 30 중량부, 보리지(Borago officinalis) 1 내지 30 중량부 및 수레국화(Centaurea cyanus) 꽃 1 내지 30 중량부로부터 수득한 추출물; 및Specifically, the cosmetic composition is prepared further comprising one or more selected from the group consisting of bergamot (citrus aurantium bergamia , bergamot) oil, tea tree ( Meleuca alternifolia ) oil, orange ( Citrus Aurantium Dulcis) oil, and sunflower seed oil. And more specifically capryloyl salicylic acid (LHA) 1 part by weight, poly-alphahydroxy acid (PHA) 1 part by weight and alpha hydroxy acid (AHA) 0.3 parts by weight, Nutmeg 20 to 50 parts by weight, 20 to 50 parts by weight of Chinese cucumber root , 10 to 40 parts by weight of Silybum marianum seeds, 10 to 40 parts by weight of elder flower, Rosa Damascena ) Flowers 10 to 30 parts by weight, lavender flowers 10 to 30 parts by weight, Salvia Sclarea 10 to 30 parts by weight, Hyacinthus
베르가못(citrus aurantium bergamia, bergamot) 오일 1 내지 5 중량부, 티트리(Melaleuca alternifolia) 오일 1 내지 5 중량부, 오렌지(Citrus Aurantium Dulcis) 오일 1 내지 5 중량부 및 해바라기씨 오일 1 내지 30 중량부를 포함하여 제조된 것일 수 있으나, 이에 제한되지 않는다.Bergamot ( citrus aurantium bergamia , bergamot)
본 발명에서 용어 “추출물”은 용매와 추출 원료를 특정 조건 하에서 접촉시킴으로써 추출 원료에 함유된 유효성분으로 천연물로부터 원료에 함유된 성분을 분리해낸 물질이라면, 추출 방법이나 성분의 종류와 무관하게 모두 포함할 수 있다.In the present invention, the term "extract" is an active ingredient contained in the raw material for extraction by contacting the solvent with the raw material for extraction under specific conditions, and includes all substances regardless of the extraction method or the type of the ingredient as long as the ingredient contained in the raw material is separated from a natural product. can do.
예컨대, 물이나 유기용매를 이용하여 천연물로부터 용매에 용해되는 성분을 추출한 것, 천연물의 특정 성분, 예컨대 오일과 같은 특정 성분만을 추출하여 얻어진 것 등을 모두 포함할 수 있다. 상기 추출물은 건조 후 분말화하거나, 열수추출법, 에탄올 추출법 등 종래 알려진 다양한 추출법에 의해 수득할 수 있다.For example, it may include extracting a component soluble in a solvent from a natural product using water or an organic solvent, and extracting a specific component of a natural product, such as extracting only a specific component such as an oil. The extract may be powdered after drying, or may be obtained by various conventionally known extraction methods such as hot water extraction and ethanol extraction.
상기 추출물은 물, 탄소수 1 내지 4개의 무수 또는 함수 저급 알코올, 아세톤, 석유에테르, 에틸아세테이트, 부틸아세테이트, 트리클로로메탄, 디클로로메탄, 클로로포름, 헥산 및 1,3-부틸렌글리콜로 이루어진 군으로부터 선택되는 하나 이상의 용매로 추출될 수 있고, 구체적으로 60 내지 80% 농도(v/v)의 에탄올에 의해 추출될 수 있다.The extract is selected from the group consisting of water, anhydrous or hydrous lower alcohol having 1 to 4 carbon atoms, acetone, petroleum ether, ethyl acetate, butyl acetate, trichloromethane, dichloromethane, chloroform, hexane and 1,3-butylene glycol It may be extracted with one or more solvents, and specifically, may be extracted with ethanol at a concentration of 60 to 80% (v/v).
상기 원료에 포함된 유효성분은 용매의 극성에 따라 추출 비율이 상이해질 수 있으며, 상기 에탄올은 천연 원료의 생리 활성 물질 추출에 있어서 선택성이 뛰어나므로 상기 에탄올 추출에 의해 최적의 피부 개선 효과가 구현될 수 있다.The active ingredient contained in the raw material may have a different extraction ratio depending on the polarity of the solvent, and the ethanol has excellent selectivity in the extraction of physiologically active substances from natural raw materials, so the optimal skin improvement effect can be realized by the ethanol extraction. I can.
상기 추출물은 추출 원료를 물로 수세한 후 건조 및 분쇄하여, 원료 중량의 2 내지 12배에 달하는 부피의 용매로 약 1 내지 24시간 동안 환류 순환 추출, 가압 추출, 초음파 추출 등 통상적인 방법으로 추출 및 여과하여 제조할 수 있다. 또한, 상기 추출물은 감압 증류 또는 동결 건조 등과 같은 추가적인 공정에 의해 분말 상태로 수득할 수 있다.The extract is extracted by conventional methods such as reflux circulating extraction, pressure extraction, ultrasonic extraction, etc. for about 1 to 24 hours with a solvent having a volume of 2 to 12 times the weight of the raw material by washing the extraction raw material with water, drying and pulverizing, and It can be prepared by filtration. In addition, the extract can be obtained in a powder state by an additional process such as distillation under reduced pressure or freeze drying.
상기 추출물은 통상적인 정제 과정을 거친 추출물도 포함할 수 있다. 예컨대, 상기 추출물은 일정한 분자량 컷-오프 값을 갖는 한외 여과막을 이용한 분리, 다양한 크로마토그래피(크기, 전하, 소수성 또는 친화성에 따른 분리를 위해 제작된 것)에 의한 분리 등 추가적으로 실시된 다양한 정제 방법을 통해 얻어진 분획물을 포함할 수 있다.The extract may also include an extract that has undergone a conventional purification process. For example, the extract may be subjected to various additional purification methods, such as separation using an ultrafiltration membrane having a certain molecular weight cut-off value, separation by various chromatography (one prepared for separation according to size, charge, hydrophobicity, or affinity). It may contain a fraction obtained through.
본 발명의 화장료 조성물은 피부 각질 제거 및 블랙헤드 개선 효과를 나타낼 수 있으며, 이를 구체적인 실험예(실험예 1)를 통하여 확인하였다.The cosmetic composition of the present invention can exfoliate skin and improve blackheads, and this was confirmed through a specific experimental example (Experimental Example 1).
특히, 본 발명은 피부와 pH가 유사해 자극이 적은 카프릴로일살리실릭산(LHA) 및 커다란 분자 구조를 가져 피부에 깊숙히 침투하지 않아 자극이 덜한 폴리-알파하이드록시애시드(PHA) 및 알파하이드록시애시드(AHA)를 포함하는 복합 필링성분을 포함함으로써 피부의 심층부 및 표층부에 선택적으로 작용함으로써 각질을 효과적으로 제거함과 동시에 피부 자극이 현저히 적은 것을 특징으로 하며(표 1), 상기 복합 필링제에 더하여 피부 진정 및 영양 흡수를 촉진하는 천연물 유래 추출물을 포함함으로써, 피부세포에 수분 및 탄력을 즉각적으로 공급하는 것을 특징으로 한다.In particular, the present invention has a low irritation capryloylsalicylic acid (LHA) with a similar pH to the skin, and a large molecular structure that does not penetrate deeply into the skin, so it is less irritating poly-alphahydroxy acid (PHA) and alphahydric acid. By including a complex peeling ingredient containing hydroxy acid (AHA), it selectively acts on the deep and surface areas of the skin, effectively removing dead skin cells and significantly less skin irritation (Table 1).In addition to the complex peeling agent, the skin By including an extract derived from a natural product that promotes soothing and nutrient absorption, it is characterized in that it immediately supplies moisture and elasticity to skin cells.
이러한 특성 때문에, 본 발명의 화장료 조성물은 피부 보습, 피부 진정, 피부 미백 및 피부 탄력 개선 효과를 추가로 포함할 수 있다(실험예 2 내지 5).Because of these properties, the cosmetic composition of the present invention may further include skin moisturizing, skin soothing, skin whitening, and skin elasticity improvement effects (Experimental Examples 2 to 5).
본 발명에서 용어 “피부 미백"은 피부색에 영향을 미치는 멜라닌, 산화-환원 헤모글로빈, 카로틴, 멜라노이드 등 다양한 생체 분자의 생성을 억제함으로써 잡티, 주근깨, 기미 등의 피부 색소 침착 현상을 완화시키고, 피부 누런기, 붉은기를 완화시켜 피부 밝기 및 균일도를 향상시키는 효과를 의미한다. 구체적으로, 본 발명에서 피부 미백은 피부톤을 환하게 하여 명도를 높이는 효과를 의미하는 것으로 사용되었으나, 이에 제한되는 것은 아니다.In the present invention, the term "skin whitening" alleviates skin pigmentation phenomena such as blemishes, freckles, and blemishes by inhibiting the production of various biomolecules such as melanin, oxidation-reduction hemoglobin, carotene, and melanoids that affect skin color, and It means the effect of improving skin brightness and uniformity by relieving yellowness and redness Specifically, in the present invention, skin whitening is used to mean an effect of increasing the brightness by brightening skin tone, but is not limited thereto.
본 발명에서 용어 “피부 진정”은 홍반 또는 자극받은 피부 부위 등을 완화시키고 가라앉히는 것을 의미한다. 예컨대, 상기 피부 진정은 염증 개선 또는 치료, 경피 수분 손실 감소 또는 붉은기 감소를 들 수 있으나, 특별히 이에 제한되는 것은 아니다.In the present invention, the term “skin soothing” refers to alleviating and soothing erythema or irritated skin areas. For example, the skin soothing may include improving or treating inflammation, reducing transdermal water loss, or reducing redness, but is not particularly limited thereto.
본 발명의 화장료 조성물은 용액, 외용 연고, 크림, 폼, 영양 화장수, 유연 화장수, 팩, 유연수, 유액, 메이크업 베이스, 에센스, 비누, 액체 세정료, 입욕제, 선 스크린 크림, 선 오일, 현탁액, 유탁액, 페이스트, 겔, 로션, 파우더, 비누, 계면 활성제-함유 클렌징, 오일, 분말 파운데이션, 유탁액 파운데이션, 왁스 파운데이션, 패취 및 스프레이로 구성된 군으로부터 선택되는 제형으로 제조할 수 있으나, 이에 제한되는 것은 아니다.The cosmetic composition of the present invention is a solution, external ointment, cream, foam, nutritional lotion, flexible lotion, pack, softening water, emulsion, makeup base, essence, soap, liquid detergent, bathing agent, sunscreen cream, sun oil, suspension, emulsion It can be prepared in a formulation selected from the group consisting of liquid, paste, gel, lotion, powder, soap, surfactant-containing cleansing, oil, powder foundation, emulsion foundation, wax foundation, patch, and spray, but is limited thereto. no.
본 발명의 상기 화장료 조성물은 일반 피부 화장료에 배합되는 화장품학적으로 허용 가능한 담체를 1 종 이상 추가로 포함할 수 있으며, 통상의 성분으로 예를 들면 유분, 물, 계면 활성제, 보습제, 저급 알코올, 증점제, 킬레이트제, 색소, 방부제, 향료 등을 적절히 배합할 수 있으나, 이에 제한되는 것은 아니다.The cosmetic composition of the present invention may additionally contain one or more cosmetically acceptable carriers blended in general skin cosmetics, and as common ingredients, for example, oil, water, surfactants, moisturizers, lower alcohols, thickeners , A chelating agent, a colorant, a preservative, a fragrance, and the like may be appropriately blended, but are not limited thereto.
본 발명의 화장료 조성물에 포함되는 화장품학적으로 허용 가능한 담체는 화장료 조성물의 제형에 따라 다양하다.The cosmetically acceptable carrier included in the cosmetic composition of the present invention varies depending on the formulation of the cosmetic composition.
본 발명의 제형이 연고, 페이스트, 크림 또는 젤인 경우에는, 담체 성분으로서 동물성 유, 식물성 유, 왁스, 파라핀, 전분, 트라칸트, 셀룰로오스 유도체, 폴리에틸렌 글리콜, 실리콘, 벤토나이트, 실리카, 탈크, 산화 아연 등이 이용될 수 있으나, 이에 제한되는 것은 아니다. 이들은 단독으로 사용되거나 2 종 이상 혼합되어 사용될 수 있다.When the formulation of the present invention is an ointment, paste, cream, or gel, as a carrier component, animal oil, vegetable oil, wax, paraffin, starch, tracant, cellulose derivative, polyethylene glycol, silicone, bentonite, silica, talc, zinc oxide, etc. May be used, but is not limited thereto. These may be used alone or in combination of two or more.
본 발명의 제형이 파우더 또는 스프레이인 경우에는, 담체 성분으로서 락토스, 탈크, 실리카, 알루미늄 히드록사이드, 칼슘 실케이트, 폴리아미드 파우더 등이 이용될 수 있고, 특히 스프레이인 경우에는 추가적으로 클로로플루오로하드로카본, 프로판/부탄 또는 디메틸 에테르와 같은 추진제를 포함할 수 있으나, 이에 제한되는 것은 아니다. 이들은 단독으로 사용되거나 2 종 이상 혼합되어 사용될 수 있다.When the formulation of the present invention is a powder or spray, lactose, talc, silica, aluminum hydroxide, calcium silicate, polyamide powder, etc. may be used as a carrier component. It may include a propellant such as locarbon, propane/butane or dimethyl ether, but is not limited thereto. These may be used alone or in combination of two or more.
본 발명의 제형이 용액 또는 유탁액인 경우에는, 담체 성분으로서 용매, 용해화제 또는 유탁화제 등이 이용될 수 있으며, 예컨대 물, 에탄올, 이소프로판올, 에틸 카보네이트, 에틸 아세테이트, 벤질 알코올, 벤질 벤조에이트, 프로필렌 글리콜, 1,3-부틸글리콜 오일 등이 이용될 수 있고, 특히, 목화씨 오일, 땅콩 오일, 옥수수 배종 오일, 올리브 오일, 피마자 오일 및 참깨 오일, 글리세롤 지방족 에스테르, 폴리에틸렌 글리콜 또는 소르비탄의 지방산 에스테르가 이용될 수 있으나, 이에 제한되는 것은 아니다. 이들은 단독으로 사용되거나 2 종 이상 혼합되어 사용될 수 있다.When the formulation of the present invention is a solution or emulsion, a solvent, a solubilizing agent or an emulsifying agent may be used as a carrier component, such as water, ethanol, isopropanol, ethyl carbonate, ethyl acetate, benzyl alcohol, benzyl benzoate, Propylene glycol, 1,3-butyl glycol oil, and the like may be used, and in particular, cottonseed oil, peanut oil, corn germ oil, olive oil, castor oil and sesame oil, glycerol aliphatic ester, polyethylene glycol or fatty acid ester of sorbitan. May be used, but is not limited thereto. These may be used alone or in combination of two or more.
본 발명의 제형이 현탁액인 경우에는, 담체 성분으로서 물, 에탄올 또는 프로필렌 글리콜과 같은 액상의 희석제, 에톡실화 이소스테아릴 알코올, 폴리옥시에틸렌 소르비톨 에스테르 및 폴리옥시에틸렌 소르비탄 에스테르와 같은 현탁제, 미소결정성 셀룰로오스, 알루미늄 메타하이드록시드, 벤토나이트, 아가 또는 트라칸트 등이 이용될 수 있으나, 이에 제한되는 것은 아니다. 이들은 단독으로 사용되거나 2 종 이상 혼합되어 사용될 수 있다.When the formulation of the present invention is a suspension, as a carrier component, a liquid diluent such as water, ethanol or propylene glycol, an ethoxylated isostearyl alcohol, a suspending agent such as polyoxyethylene sorbitol ester and polyoxyethylene sorbitan ester, micro Crystalline cellulose, aluminum metahydroxide, bentonite, agar, or tracant may be used, but is not limited thereto. These may be used alone or in combination of two or more.
구체적으로, 본 발명에서는 락틱애씨드, 카프릴로일살리실릭애씨드, 락토바이오닉애씨드, 하이드로제네이티드레시틴, 자일리틸글루코사이드, 안하이드로자일리톨, 스테아릭애씨드, 글루코오스, 세라마이드엔피, 피토스핑고신, 세라마이드엔에스, 콜레스테롤, 에틸헥실글리세린, 세라마이드에이에스, 세라마이드에이피, 세라마이드이오피, 에틸헥실팔미테이트, 펜틸렌글라이콜, 카프릴릭/카프릭트라이글리세라이드, 프로필렌글라이콜, 글라이콜릭애씨드, 1,2-헥산다이올, 세테스-20, 글리세릴스테아레이트, 솔비탄스테아레이트, 세테아릴알코올, 메틸글루코오스세스퀴스테아레이트, 사이클로덱스트린, 폴리글리세릴-4아이소스테아레이트, 소듐하이드록사이드, 스클레로튬검, 글리세린, 폴리글리세릴-4카프레이트 및 부틸렌글라이콜로 이루어진 군에서 하나 이상 선택된 것을 포함하여 제조할 수 있으나, 이에 제한되는 것은 아니다.Specifically, in the present invention, in the present invention, lactic acid, capryloyl salicylic acid, lactobanic acid, hydrogenated lecithin, xylitol glucoside, anhydroxylitol, stearic acid, glucose, ceramide NP, phytosphingosine, ceramide NS , Cholesterol, ethylhexyl glycerin, ceramide AS, ceramide AP, ceramide EP, ethylhexyl palmitate, pentylene glycol, caprylic/capric triglyceride, propylene glycol, glycolic acid, 1,2- Hexanediol, ceteth-20, glyceryl stearate, sorbitan stearate, cetearyl alcohol, methyl glucose sesquistearate, cyclodextrin, polyglyceryl-4 isostearate, sodium hydroxide, scle It may be prepared including one or more selected from the group consisting of rotium gum, glycerin, polyglyceryl-4 caprate, and butylene glycol, but is not limited thereto.
본 발명의 화장료 조성물은 피부와 pH가 유사해 자극이 적은 카프릴로일살리실릭산(LHA) 및 커다란 분자 구조를 가져 피부에 깊숙히 침투하지 않아 자극이 덜한 폴리-알파하이드록시애시드(PHA) 및 알파하이드록시애시드(AHA)를 포함하는 복합 필링성분을 포함함으로써 피부의 심층부 및 표층부에 선택적으로 작용함으로써 각질을 효과적으로 제거함과 동시에 피부 자극이 현저히 적은 것을 특징으로 한다.The cosmetic composition of the present invention has a low irritation capryloylsalicylic acid (LHA) with a similar pH to the skin, and a large molecular structure that does not penetrate deeply into the skin, so it is less irritating poly-alphahydroxy acid (PHA) and alpha. By including a complex peeling component containing hydroxy acid (AHA), it selectively acts on the deep and superficial parts of the skin to effectively remove dead skin cells and to significantly reduce skin irritation.
또한, 본 발명의 화장료 조성물은 상기 복합 필링제에 더하여 피부 진정 및 영양 흡수를 촉진하는 천연물 유래 추출물을 포함함으로써, 피부세포에 수분 및 탄력을 즉각적으로 공급하는 것을 특징으로 한다.In addition, the cosmetic composition of the present invention is characterized in that it immediately supplies moisture and elasticity to skin cells by including an extract derived from a natural product that promotes skin soothing and nutrient absorption in addition to the complex peeling agent.
나아가, 본 발명의 화장료 조성물은 피부자극 테스트 결과 무자극으로 판정되어 민감성 피부 및 임산부에게도 사용 가능한 것을 특징으로 한다.Further, the cosmetic composition of the present invention is determined as non-irritating as a result of a skin irritation test, and is characterized in that it can be used for sensitive skin and pregnant women.
또한, 본 발명의 조성물은 천연물 유래의 물질이어서 독성이 없으며, 인체에 적용하여도 부작용을 유발하지 않아 화장료 조성물로의 활용도가 높다. In addition, since the composition of the present invention is a material derived from a natural product, it is not toxic, and even when applied to the human body, it does not cause side effects, so its utilization as a cosmetic composition is high.
본 발명의 효과는 상기한 효과로 한정되는 것은 아니며, 본 발명의 상세한 설명 또는 청구범위에 기재된 발명의 구성으로부터 추론 가능한 모든 효과를 포함하는 것으로 이해되어야 한다.The effects of the present invention are not limited to the above effects, and should be understood to include all effects that can be deduced from the configuration of the invention described in the detailed description or claims of the present invention.
도 1은 본 발명 화장료 조성물을 사용한 후의 피부 각질 및 블랙헤드 개선 효과를 확인한 결과를 나타낸 것이다.
도 2는 본 발명 화장료 조성물의 피부자극 테스트 결과, 무자극으로 판정된 것을 확인한 결과를 나타낸 것이다(한국피부과학연구원 시험번호: KIDS-AIL001-MDM의 표 4).
도 3은 본 발명 화장료 조성물을 사용하는 경우 피부 보습, 미백 및 탄력 개선 효과를 확인한 결과를 나타낸 것이다.1 shows the result of confirming the effect of improving skin dead skin cells and blackheads after using the cosmetic composition of the present invention.
Figure 2 shows the results of the skin irritation test result of the cosmetic composition of the present invention, the result of confirming that it was determined to be non-irritating (Korea Research Institute of Dermatology Test No.: Table 4 of KIDS-AIL001-MDM).
Figure 3 shows the results of confirming the effect of improving skin moisturizing, whitening and elasticity when using the cosmetic composition of the present invention.
이하, 본 발명을 실시예에 의해 상세히 설명한다. 단, 하기 실시예는 본 발명을 예시하는 것일 뿐, 본 발명이 하기 실시예에 의해 한정되는 것은 아니다.Hereinafter, the present invention will be described in detail by examples. However, the following examples are merely illustrative of the present invention, and the present invention is not limited by the following examples.
실시예 1. 천연물 유래 혼합 추출물의 제조Example 1. Preparation of mixed extract derived from natural products
본 발명의 화장료 조성물을 제조하기에 앞서, 천연물 유래 혼합 추출물을 제조하였다.Prior to preparing the cosmetic composition of the present invention, a mixed extract derived from a natural product was prepared.
구체적으로, 육두구(Nutmeg), 하늘타리(Chinese cucumber) 뿌리, 흰무늬엉겅퀴(Silybum marianum) 씨, 엘더플라워(Elder flower), 다마스크장미(Rosa Damascena) 꽃, 라벤더꽃, 클레리(Salvia Sclarea), 히아신스(Hyacinthus)전초, 마트리카리아(Matricaria chamomilla) 꽃, 보리지(Borago officinalis) 및 수레국화(Centaurea cyanus) 꽃을 깨끗이 씻어 준비하고, 이를 -60℃ 내지 -80℃ 조건에서 동결 건조 처리하였다.Specifically, Nutmeg, Chinese cucumber root, white pattern thistle ( Silybum marianum ) seed, elder flower, Rosa Damascena flower, lavender flower, Salvia Sclarea , Hyacinth (Hyacinthus) outpost, Matricaria chamomilla flowers, Borago officinalis and cornflower ( Centaurea cyanus ) flowers were washed and prepared, and freeze-dried at -60°C to -80°C.
더욱 구체적으로는, 육두구(Nutmeg) 30 중량부, 하늘타리(Chinese cucumber) 뿌리 30 중량부, 흰무늬엉겅퀴(Silybum marianum) 씨 20 중량부, 엘더플라워(Elder flower) 20 중량부, 다마스크장미(Rosa Damascena) 꽃 20 중량부, 라벤더 꽃 15 중량부, 클레리(Salvia Sclarea) 15 중량부, 히아신스(Hyacinthus) 전초 10 중량부, 마트리카리아(Matricaria chamomilla) 꽃 10 중량부, 보리지(Borago officinalis) 10 중량부 및 수레국화(Centaurea cyanus) 꽃 10 중량부를 깨끗이 씻어 준비하고, 이를 -60℃ 내지 -80℃ 조건에서 동결 건조 처리하였다.More specifically, 30 parts by weight of Nutmeg, 30 parts by weight of Chinese cucumber root , 20 parts by weight of Silybum marianum seeds, 20 parts by weight of Elder flower, Rosa Damascena flowers 20 parts by weight, lavender flowers 15 parts by weight, Salvia Sclarea 15 parts by weight, Hyacinthus outpost 10 parts by weight, Matricaria chamomilla flowers 10 parts by weight, Borago officinalis 10 parts by weight and 10 parts by weight of cornflower ( Centaurea cyanus ) flowers were washed and prepared, and freeze-dried at -60°C to -80°C.
이후, 각 재료의 2배 중량의 정제수를 혼합하여 수분을 흡수시키고, 70%(v/v) 에탄올을 용매로 하여 2시간동안 환류 추출하였다. Thereafter, purified water of twice the weight of each material was mixed to absorb moisture, and extracted under reflux for 2 hours using 70% (v/v) ethanol as a solvent.
상기 추출물을 250메쉬 및 0.5㎛ 필터에 의해 여과하였으며, 40℃에서 감압 농축하여 천연물 유래 추출물을 수득하였다.The extract was filtered through a 250 mesh filter and a 0.5 μm filter, and concentrated under reduced pressure at 40° C. to obtain an extract derived from a natural product.
실시예 2. 천연 허브 유래의 에센셜 오일의 제조Example 2. Preparation of essential oil derived from natural herbs
본 발명 화장료 조성물을 제조하기 위하여 천연 허브 유래의 에센셜 오일을 제조하였다. Essential oils derived from natural herbs were prepared to prepare the cosmetic composition of the present invention.
구체적으로, 베르가못(citrus aurantium bergamia, bergamot), 티트리(Melaleuca alternifolia) 잎 및 오렌지(Citrus Aurantium Dulcis) 껍질을 세척하고 물기를 제거하여 준비한 후, 상업용 오일 추출기 탱크에 원료를 각각 투입하고 추출기를 3 내지 4시간동안 가동하여 오일 추출물을 제조하였다. Specifically, bergamot ( citrus aurantium bergamia , bergamot), tea tree ( Melaleuca alternifolia ) leaves and orange ( Citrus Aurantium Dulcis ) peels were prepared by washing and removing moisture, and then the raw materials were added to a commercial oil extractor tank, respectively, and the extractor was 3 The oil extract was prepared by running for 4 hours.
구체적으로, 상기 원료 각각에 대하여 정제수와의 비율이 1:2.5 정도가 되도록 증류탱크에 넣은 후 증류탱크의 추출 온도를 90℃로 유지하면서 3 내지 4시간동안 증류시켰다. 이때 냉각기 내부에 공급되는 냉각수의 온도는 10℃정도로 유지하며, 냉각기를 통과한 응축물을 분리탱크에 수집하였다.Specifically, the raw materials were placed in a distillation tank so that the ratio of each of the raw materials to purified water was about 1:2.5, and then distilled for 3 to 4 hours while maintaining the extraction temperature of the distillation tank at 90°C. At this time, the temperature of the cooling water supplied to the inside of the cooler was maintained at about 10°C, and the condensate passed through the cooler was collected in a separation tank.
상기 수집된 응축물은 기름과 물이 혼재되어 있으며, 분류 탱크에서 오일과 하이드로졸이 분리되면 약 3회에 걸쳐 하이드로졸을 받고, 최종 오일을 함유한 하이드로졸 잔류물을 받아서 분리기를 통해 하이드로졸과 오일을 분리하였다. 분리된 오일층에서 순수 오일을 취득하기 위해서 1차 분리된 오일을 냉동실에 1일 동안 보관하여 얼지 않은 오일 만을 채취하여 에센셜 오일을 수득하였다.The collected condensate is a mixture of oil and water, and when the oil and hydrosol are separated in the sorting tank, the hydrosol is received about 3 times, and the hydrosol residue containing the final oil is received and the hydrosol is used through a separator. And oil were separated. In order to obtain pure oil from the separated oil layer, the first separated oil was stored in a freezer for 1 day, and only unfrozen oil was collected to obtain essential oil.
해바라기(Helianthus annuus) 씨 오일을 추출하기 위해 해바라기씨를 선별하여 이물 제거 후, 세척하였다. 그 후 해바라기씨를 수분 함량 17% 이하로 건조하고, 건조된 해바라기씨를 저온상태로 스크류 압착식 방법을 통해 착유하였고, 착유된 해바라기씨 오일을 여과기를 통과시켜 고순도의 해바라기씨 오일을 수득하였다.In order to extract sunflower ( Helianthus annuus ) seed oil, sunflower seeds were selected, foreign substances were removed, and then washed. Thereafter, the sunflower seeds were dried to a moisture content of 17% or less, and the dried sunflower seeds were milked at a low temperature through a screw compression method, and the milked sunflower seed oil was passed through a filter to obtain high-purity sunflower seed oil.
실시예 3. 천연물 유래 추출물 및 에센셜 오일을 함유하는 화장료 조성물의 제조Example 3. Preparation of cosmetic composition containing extracts derived from natural products and essential oils
상기 실시예 1 및 2에서 제조한 물질을 포함하여 본 발명의 화장료 조성물을 제조하였다.A cosmetic composition of the present invention was prepared, including the materials prepared in Examples 1 and 2.
구체적으로, 본 발명의 화장료 조성물은 상기 실시예 1에서 제조한 천연물 유래 혼합 추출물 30 중량부, 실시예 2에서 제조한 베르가못 오일 3 중량부, 티트리잎 오일 3 중량부, 오렌지 오일 2 중량부 및 해바라기씨 오일 15 중량부를 포함하여 제조하였으며, 더욱 구체적으로는 스쿠알란(Squalane) 5 중량부, 자일리틸글루코사이드(xylitylpolyglucoside) 1 중량부 및 무수자일리톨 1 중량부를 추가로 더 포함하여 제조하였다.Specifically, the cosmetic composition of the present invention comprises 30 parts by weight of the mixed extract derived from natural products prepared in Example 1, 3 parts by weight of bergamot oil prepared in Example 2, 3 parts by weight of tea tree leaf oil, 2 parts by weight of orange oil, and It was prepared including 15 parts by weight of sunflower seed oil, and more specifically, 5 parts by weight of squalane, 1 part by weight of xylitylpolyglucoside, and 1 part by weight of anhydrous xylitol were further included.
또한, 본 발명 화장료 조성물의 각질 제거 효과를 강화하기 위하여, 모공 속 피지를 선택적으로 제거할 수 있는 복합 필링 성분으로서, 카프릴로일살리실릭애씨드(Capryloyl Salicylic Acid, LHA), 폴리-알파하이드록시애시드(PHA) 및 알파하이드록시애시드(AHA)를 추가로 더 포함하였으며, 구체적으로는 카프릴로일살리실릭애씨드(LHA) 1 중량부, 폴리-알파하이드록시애시드(PHA) 1 중량부 및 알파하이드록시애시드(AHA) 0.3 중량부를 추가하였다. 상기 폴리-알파하이드록시애시드(PHA) 및 알파하이드록시애시드(AHA)는 각각 락토바이오닉애시드(PHA) 및 락틱애시드(AHA)로 불리기도 한다.In addition, in order to enhance the exfoliating effect of the cosmetic composition of the present invention, as a complex peeling component capable of selectively removing sebum in pores, Capryloyl Salicylic Acid (LHA), poly-alphahydroxy acid (PHA) and alpha hydroxy acid (AHA) were further included, specifically capryloyl salicylic acid (LHA) 1 part by weight, poly-alphahydroxy acid (PHA) 1 part by weight and alpha hydroxy 0.3 parts by weight of acid (AHA) was added. The poly-alpha hydroxy acid (PHA) and alpha hydroxy acid (AHA) are also referred to as lactobionic acid (PHA) and lactic acid (AHA), respectively.
한편, 본 발명 화장료 조성물은 일반적으로 화장료 조성물의 제조에 사용되는 각종 부형제, 부가제 및 첨가제를 포함하여 제조될 수 있으며, 구체적으로는 하이드로제네이티드레시틴, 자일리틸글루코사이드, 안하이드로자일리톨, 스테아릭애씨드, 글루코오스, 세라마이드엔피, 피토스핑고신, 세라마이드엔에스, 콜레스테롤, 에틸헥실글리세린, 세라마이드에이에스, 세라마이드에이피, 세라마이드이오피, 에틸헥실팔미테이트, 펜틸렌글라이콜, 카프릴릭/카프릭트라이글리세라이드, 프로필렌글라이콜, 글라이콜릭애씨드, 1,2-헥산다이올, 세테스-20, 글리세릴스테아레이트, 솔비탄스테아레이트, 세테아릴알코올, 메틸글루코오스세스퀴스테아레이트, 사이클로덱스트린, 폴리글리세릴-4아이소스테아레이트, 소듐하이드록사이드, 스클레로튬검, 글리세린, 폴리글리세릴-4카프레이트 및 부틸렌글라이콜로 이루어진 군에서 하나 이상 선택된 것을 포함하여 제조할 수 있으나, 이에 제한되지 않고 필요에 따라 적절히 변경하여 적용 가능하다.Meanwhile, the cosmetic composition of the present invention may be prepared including various excipients, additives, and additives generally used in the preparation of cosmetic compositions, and specifically, hydrogenated lecithin, xylitol glucoside, anhydroxylitol, stearic acid , Glucose, ceramide NP, phytosphingosine, ceramide NS, cholesterol, ethylhexyl glycerin, ceramide A. Propylene glycol, glycolic acid, 1,2-hexanediol, ceteth-20, glyceryl stearate, sorbitan stearate, cetearyl alcohol, methyl glucose sesquistearate, cyclodextrin, polyglyceride Reel-4 isostearate, sodium hydroxide, sclerotium gum, glycerin, polyglyceryl-4 caprate, and may be prepared including one or more selected from the group consisting of butylene glycol, but is not limited thereto and required It can be applied by changing appropriately according to the requirements.
비교예 1. 천연물 유래 추출물을 포함하지 않는 화장료 조성물의 제조Comparative Example 1. Preparation of cosmetic composition not containing extracts derived from natural products
실시예 3의 제조과정에서 실시예 1의 천연물 유래 추출물을 포함하지 않고 제조한 것을 제외하고는 동일한 방법으로 비교예 1의 화장료 조성물을 제조하였다.The cosmetic composition of Comparative Example 1 was prepared in the same manner, except that it was prepared without including the extract derived from the natural product of Example 1 in the manufacturing process of Example 3.
비교예 2. 에센셜 오일을 포함하지 않는 화장료 조성물의 제조Comparative Example 2. Preparation of cosmetic composition not containing essential oil
실시예 3의 제조과정에서 실시예 2의 에센셜 오일을 포함하지 않고 제조한 것을 제외하고는 동일한 방법으로 비교예 2의 화장료 조성물을 제조하였다.The cosmetic composition of Comparative Example 2 was prepared in the same manner, except that the essential oil of Example 2 was not included in the manufacturing process of Example 3 and was prepared.
비교예 3. 복합 필링 성분을 포함하지 않는 화장료 조성물의 제조Comparative Example 3. Preparation of a cosmetic composition not containing a complex peeling component
실시예 3의 제조과정에서 복합 필링 성분인 LHA, PHA 및 AHA를 포함하지 않고 제조한 것을 제외하고는 동일한 방법으로 비교예 3의 화장료 조성물을 제조하였다.The cosmetic composition of Comparative Example 3 was prepared in the same manner except that it was prepared without including LHA, PHA, and AHA, which are complex peeling components in the manufacturing process of Example 3.
실험예 1. 각질 제거 및 블랙헤드 개선효과 임상시험Experimental Example 1. Clinical trial of exfoliating and blackhead improvement effect
인체를 대상으로 본 발명 화장료 조성물의 각질 제거 및 블랙헤드 개선 효과를 확인하기 위하여 임상 시험을 실시하였다.A clinical test was conducted to confirm the effect of removing dead skin cells and improving blackheads of the cosmetic composition of the present invention in humans.
본 실험예는 1주간 30~50대의 남녀 20명을 대상으로 진행하였고, 상기 실시예 및 비교예의 조성물을 코를 포함한 얼굴에 매일 1회씩 사용하고, 각질 제거 및 블랙헤드 개선 정도를 측정하여 이루어졌다. This experimental example was conducted for 20 men and women in their 30s to 50s for 1 week, and the compositions of the examples and comparative examples were used once a day on the face including the nose, and the extent of exfoliation and blackhead improvement was measured. .
구체적으로, 상기 남녀 20명을 4명씩 5개 그룹으로 나누어 실시예 1 및 비교예 1, 2의 조성물을 각 그룹별로 2일 간격으로 1주간 얼굴에 사용하였고, 대조군 4명은 시중에 판매중인 필링 마스크를 사용하도록 하였다.Specifically, the composition of Example 1 and Comparative Examples 1 and 2 was divided into 5 groups of 4 men and 20 men, and the compositions of Example 1 and Comparative Examples 1 and 2 were used on the face for 1 week at 2 days intervals for each group, and 4 control groups were commercially available peeling masks. I was supposed to use.
1주 경과 후, 실험 참여자들을 대상으로 각질 제거효과, 블랙헤드 개선, 피부 컨디션 및 종합 선호도를 평가하였다.After 1 week, the participants were evaluated for exfoliating effect, blackhead improvement, skin condition and overall preference.
각질 제거효과 항목은 각질이 잘 제거되는지 여부를, 블랙헤드 개선 항목은 팩을 제거한 직후의 블랙헤드 제거효과 및 재발 정도를 종합적으로 평가한 것이고, 피부 컨디션은 각질 제거 및 블랙헤드 제거 효과에 의한 피부 발적, 자극, 보습도의 하락 등 사용자가 느낄 수 있는 종합적인 컨디션을 평가한 것이다.The exfoliating effect item is whether or not dead skin cells are removed well, the blackhead improvement item is a comprehensive evaluation of the effect of removing blackheads and the degree of recurrence immediately after the pack is removed, and the skin condition is the skin by exfoliating and removing blackheads. This is an evaluation of the overall condition that users can feel, such as redness, irritation, and decrease in moisture level.
평가는 5점 평점법으로서, 만족도가 높을수록 높은 점수를 주도록 하였으며, 예를 들어, 블랙헤드 개선 항목이 5점이면 블랙헤드가 현저히 개선되어 거의 보이지 않는 것을 의미한다.The evaluation is a 5-point scoring method, and the higher the satisfaction is, the higher the score is given. For example, if the blackhead improvement item is 5, it means that the blackhead is remarkably improved and is almost invisible.
상기 표 1에 나타난 결과와 같이, 본 발명 실시예 3의 조성물을 사용한 경우 대조군 및 비교예 1 내지 3과 비교하여 모든 항목에서 현저히 우수한 효과를 확인하였으며, 특히 일반적으로 시중에서 구할 수 있는 필링 마스크를 매일 사용한 대조군에서는 피부 컨디션에 특히 낮은 점수를 주었으나, 본 발명의 실시예 및 비교예는 전부 4점 이상의 높은 점수를 확인하였다. 실시예 1의 천연물 유래 추출물을 제외한 비교예 1에서는 실시예 3 및 비교예 2와 비교하여 모든 항목에서 상당한 효과 하락을 확인하였으며, 에센셜 오일을 제외한 비교예 2에서는 실시예 3 대비 모든 항목에서 비교적 적은 효과 하락을 확인하였다.As shown in Table 1 above, when the composition of Example 3 of the present invention was used, remarkably excellent effects were confirmed in all items compared to the control and Comparative Examples 1 to 3, and in particular, a peeling mask generally available on the market was used. In the control group used daily, a particularly low score was given to the skin condition, but all of the examples and comparative examples of the present invention confirmed a high score of 4 or more. In Comparative Example 1 except for the extract derived from the natural product of Example 1, a significant drop in effect was confirmed in all items compared to Example 3 and Comparative Example 2, and in Comparative Example 2 except for essential oils, relatively little in all items compared to Example 3 It was confirmed that the effect declined.
또한, 복합 필링 성분을 제외한 비교예 3의 경우 각질 및 블랙헤드 개선 효과는 현저히 하락하였으나, 동시에 피부 컨디션에는 크게 영향을 주지 않은 것을 확인하였다.In addition, in the case of Comparative Example 3 excluding the complex peeling component, the effect of improving keratin and blackheads significantly decreased, but at the same time, it was confirmed that it did not significantly affect the skin condition.
즉, 상기한 결과를 종합하여 볼 때, 본 발명의 화장료 조성물이 우수한 각질 제거 및 블랙헤드 개선 효과를 나타내는 것을 확인하였다.That is, when the above results are combined, it was confirmed that the cosmetic composition of the present invention exhibited excellent exfoliation and blackhead improvement effects.
실험예 2. 피부 자극도 확인 실험Experimental Example 2. Experiment to confirm skin irritation
본 발명 화장료 조성물의 피부 자극도를 확인하기 위하여, 한국피부과학연구원에서 2019년 11월 22일부터 동년 12월 23일까지 피부첩포에 의한 피부 일차자극 평가에 대한 인체적용시험(시험번호: KIDS-AIL001-MDM)을 실시하였다.In order to confirm the skin irritation level of the cosmetic composition of the present invention, a human application test for the evaluation of skin primary irritation by a skin patch from November 22, 2019 to December 23, 2019 at the Korea Dermatological Research Institute (test number: KIDS- AIL001-MDM) was implemented.
본 발명 실시예 3의 조성물을 24시간 동안 피부에 첩포하고, 첩포 제거 후 30분, 24시간, 48시간 경과 후의 시험부위에서 나타난 피부반응을 국제접촉피부염연구회의 판정기준에 따라 자극 정도를 분류하고 결과 판정표에 따라 평균 피부반응도(Mean score)를 구하였다. 그 결과, 첩포 제거 후 30분, 24시간, 48시간 경과 후에 자극이 관찰되지 않았다. 평균 피부반응도는 0.00으로 판정기준에 따라 무자극으로 판정되었다.The composition of Example 3 of the present invention was applied to the skin for 24 hours, and the skin reactions appeared at the test site 30 minutes, 24 hours, and 48 hours after removal of the patch were classified according to the criteria of the International Contact Dermatitis Research Council. The average skin reactivity (Mean score) was calculated according to the result judgment table. As a result, no irritation was observed after 30 minutes, 24 hours, and 48 hours after removal of the patch. The average skin reactivity was 0.00, which was judged as non-irritating according to the criteria.
구체적으로, 상기 피부자극 평가를 위하여 한국피부과학연구원의 항온항습실(온도: 22±2℃, 습도: 50±5%)에서 30분간 안정을 취한 뒤 측정을 실시하였으며, 20세 이상의 여성 34명(평균연령 47.79세)을 대상으로 Finn Chambers (SmartPractice, USA)를 이용하여 피부첩포시험을 실시하였다. 피시험자의 등부위를 70% 에탄올로 닦아내고 건조시킨 다음, 시험물질 20 μL를 직경 8의 Finn Chamber에 적하하고 시험부위에 부착하여 고정하였으며, 24시간 동안 부착 후 첩포 제거 후 30분, 24시간, 48시간 경과 후 피부과 전문의에 의해 국제접촉피부염연구회(International Contact Dermatitis Research Group: ICDRG)의 판정기준에 따라 피부의 자극 정도를 관찰하였다. 평균 피부반응도는 평균 피부반응도 계산공식에 따라 산정하였다.Specifically, for the skin irritation evaluation, measurements were performed after resting for 30 minutes in a constant temperature and humidity room (temperature: 22±2℃, humidity: 50±5%) of the Korea Dermatological Research Institute. A skin patch test was conducted using Finn Chambers (SmartPractice, USA) on average age 47.79 years old). After wiping the back of the test subject with 70% ethanol and drying it, 20 μL of the test substance was dropped into a Finn Chamber with a diameter of 8 and fixed by attaching it to the test site. After attaching for 24 hours, after removing the patch, 30 minutes, 24 hours, After 48 hours, the degree of skin irritation was observed by a dermatologist according to the criteria of the International Contact Dermatitis Research Group (ICDRG). The average skin reactivity was calculated according to the average skin reactivity calculation formula.
실험예 3. 피부 보습 효과 확인Experimental Example 3. Confirmation of skin moisturizing effect
본 발명 화장료 조성물을 피부에 1회 도포 시, 피부 보습 지속력을 알아보기 위하여, 건조를 호소하거나, 건성 피부라고 생각되는 20~50대 성인 남, 녀 15명에게 상기의 화장료 조성물을 얼굴 및 전박 내측에 도포한 후, 24시간 동안 코니오미터(corneometer; CM820 courage Khazaka electronic GmbH, Germany)를 이용하여 피부 수분량을 측정하였다. 코니오미터는 피부의 표피 내에 존재하는 수분의 양을 센서를 이용하여 수분의 이온 정도를 측정하고 이를 수치화하여 수분의 양을 계산함으로써 보습력을 측정하는 것이다.When applying the cosmetic composition of the present invention to the skin once, in order to find out the lasting power of skin moisturizing, apply the above cosmetic composition to 15 males and females in their 20s to 50s who complain of dryness or are considered to be dry skin. After coating on, the skin moisture content was measured using a corneometer (CM820 courage Khazaka electronic GmbH, Germany) for 24 hours. The coniometer measures the amount of moisture present in the skin's epidermis using a sensor to measure the level of ions in moisture and quantifies it to calculate the amount of moisture to measure the moisturizing power.
구체적으로, 측정하고자 하는 피부 부위에 코니어미터 프로브를 올려놓고, 프로브를 피부에 누르면 센서를 통하여 피부의 전기 전도도(capacitance)가 수치화되어 화면에 표시되며, 이를 확인하는 방법으로 측정하였다.Specifically, a cornimeter probe is placed on the skin to be measured, and when the probe is pressed against the skin, the electrical conductivity of the skin is quantified through the sensor and displayed on the screen, which is measured by a method of checking.
상기 방법으로 미리 도포 시작 전 항온, 항습 조건(24℃, 습도 40%)에서 코니오미터를 이용하여 피부 수분량을 측정하여 기본 값으로 삼고, 12시간, 24시간 경과 후의 변화를 측정하였다. 그 결과는 하기 표 2에 나타난 바와 같다.In the above method, the skin moisture content was measured using a coniometer under constant temperature and humidity conditions (24° C., humidity 40%) before the start of application, as a basic value, and changes after 12 hours and 24 hours were measured. The results are as shown in Table 2 below.
상기 표 2에 나타난 바와 같이, 실시예 3의 조성물을 도포한 경우 보습력이 24시간 이상 지속되고 피부 수분 함량 증가 효과 또한 비교예 1 및 2를 도포한 경우에 비해 현저히 높음을 확인하였다.As shown in Table 2, it was confirmed that when the composition of Example 3 was applied, the moisturizing power lasted for 24 hours or more, and the effect of increasing the skin moisture content was also significantly higher than that when Comparative Examples 1 and 2 were applied.
실험예 4. 피부 진정 효과 확인Experimental Example 4. Confirmation of skin soothing effect
자극에 민감하거나, 민감성 피부라 생각되는 성인 남, 녀 30명(나이 28±3)을 선발하여, 항온, 항습 조건(24~ 26℃, 상대 습도 40 ~ 50%)에서 1시간을 대기시킨 후, 여름철 얼굴의 온도 상승시와 같은 효과를 나타내기 위해 운동(25분간 줄넘기)을 통해 얼굴에 열을 발생시켰다. 이후, 상기 실시예 3 및 비교예 1, 2의 조성물을 한쪽 광대뼈 부위에 펴 바르고 10분간 방치한 후, 이를 제거하고 제거 직후부터 시간에 따른 피부 온도를 측정하고, 그 결과를 하기 표 3에 나타내었다. Select 30 males and females (age 28±3) who are sensitive to irritation or think sensitive skin, and wait for 1 hour under constant temperature and humidity conditions (24~26℃, relative humidity 40~50%). , In order to achieve the same effect as when the temperature of the face rises in summer, heat was generated on the face through exercise (a 25-minute jump rope). Thereafter, the compositions of Example 3 and Comparative Examples 1 and 2 were spread on one cheekbone area and left for 10 minutes, and then removed and skin temperature over time was measured immediately after removal, and the results are shown in Table 3 below. I got it.
상기 표 3에 나타난 바와 같이, 피부 온도 변화에 있어서 실시예 3의 경우 비교예 1, 2에 비하여 온도 저하 정도가 더 크고, 시간이 지나도 상대적으로 더 낮은 온도를 유지하는 것을 확인할 수 있었다. 특히 비교예 1의 경우, 피부 온도가 약간 감소하였을 뿐 크게 감소하지 못하였고, 시간이 흐른 후에도 실시예 3에 비해 여전히 높은 온도를 나타내는 것을 알 수 있었다.상기와 같은 결과로부터 실시예 3의 경우 낮은 피부 온도를 지속적으로 유지시켜 줌으로써 피부 진정 효과가 실질적으로 일어날 수 있게 하는 효과가 우수함을 확인하였다.As shown in Table 3, in the case of Example 3 in terms of skin temperature change, the degree of temperature decrease was greater than that of Comparative Examples 1 and 2, and it was confirmed that a relatively lower temperature was maintained over time. In particular, in the case of Comparative Example 1, the skin temperature decreased slightly but not significantly decreased, and it was found that the temperature was still higher than that of Example 3 even after the passage of time. From the above results, in the case of Example 3 was low. It was confirmed that the effect of allowing the skin soothing effect to occur substantially by continuously maintaining the skin temperature is excellent.
실험예 5. 피부 미백 및 탄력도 확인 시험Experimental Example 5. Skin whitening and elasticity check test
본 발명의 화장료 조성물의 미백 효과를 확인하기 위하여 상기 실시예 및 비교예의 조성물에 대한 인체 적용실험을 실시하였다. In order to confirm the whitening effect of the cosmetic composition of the present invention, human application experiments were conducted on the compositions of Examples and Comparative Examples.
미백 효과의 확인은 3주간 30~50대의 남녀 25명을 대상으로 진행하였고, 상기 실시예 및 비교예의 조성물을 손등에 적용하여 색소 침착 및 피부톤(밝기)의 개선 정도와 피부 탄력 개선 효과를 측정하여 이루어졌다. The whitening effect was checked for 25 men and women in their 30s to 50s for 3 weeks, and by applying the compositions of Examples and Comparative Examples to the back of the hand, the degree of improvement of pigmentation and skin tone (brightness) and the effect of improving skin elasticity were measured. Was done.
구체적으로, 상기 남녀 25명을 5명씩 4개 그룹으로 나누어 실시예 3 및 비교예 1 내지 3의 조성물을 각 그룹별로 매일 3회씩 3주간 손등에 사용하였고, 대조군 5명은 시중에서 미백 기능성 미스트를 매일 3회씩 3주간 분무하였다. Specifically, the 25 men and women were divided into 4 groups of 5 people, and the compositions of Example 3 and Comparative Examples 1 to 3 were used on the back of the hand 3 times a day for each group for 3 weeks, and 5 control groups used a whitening functional mist on the market every day. It was sprayed 3 times for 3 weeks.
이후, 3주 경과 후의 피부의 피부톤(명도) 차이를 색차계를 사용하여 측정하여 미백효과를 판단하였다. 이 때, 피부톤 측정에 앞서 모든 피시험자는 손을 깨끗이 세척하고 3회씩 측정한 평균값을 기록하였고, 상기 색차계는 시중에서 구매할 수 있는 휴대용 색차계(TES-135A)를 이용하여 측정하였다.Thereafter, the difference in skin tone (brightness) of the skin after 3 weeks was measured using a color difference meter to determine the whitening effect. At this time, prior to skin tone measurement, all test subjects washed their hands thoroughly and recorded the average value measured three times, and the color difference meter was measured using a commercially available portable color difference meter (TES-135A).
상기 색차계는 L*a*b* 표색계를 이용하여 색을 표시하며, 본 실험에서는 L*값(명도)을 지표로 하여 피부톤의 개선 여부를 판별하였다. 즉, L*값은 검정색(L*=0)으로부터 흰색(L*=100) 까지를 나타내므로, 3주 후 L*값에서 처음 L*값을 뺀 값을 피부 명도의 변화 값(ΔL*)으로 정의하고, 각 그룹별로 3주 후의 ΔL* 평균값을 구하여 표 4에 나타내었다.The color difference meter displays colors using an L*a*b* colorimeter, and in this experiment, it was determined whether or not the skin tone was improved using the L* value (brightness) as an index. That is, since L* value represents from black (L*=0) to white (L*=100), after 3 weeks, the value obtained by subtracting the first L* value from the L* value is the change in skin brightness (ΔL*) It was defined as, and the average value of ΔL* after 3 weeks for each group was calculated and shown in Table 4.
또한, 피부 탄력 개선 효과는 3주간의 사용 전 후의 피부 탄력을 피부탄력측정기(cutometer SEM 575, C+K Electronic Co., Germany)를 이용하여 측정하고, 피부의 점탄성(viscoelasticity)의 성질을 나타내는 R8의 변화 값(ΔR8)으로 하기 표 4에 나타내었다.In addition, the skin elasticity improvement effect was measured using a skin elasticity meter (cutometer SEM 575, C+K Electronic Co., Germany) for 3 weeks before and after use, and R8, which indicates the property of the viscoelasticity of the skin. It is shown in Table 4 below as the change value of (ΔR8).
상기 표 4에 나타난 바와 같이, 본 발명 실시예 3의 조성물을 사용하는 경우 현저히 우수한 미백 효과를 확인하였으며, 시중에서 판매중인 포타슘알룸을 포함하는 미백 미스트보다 우수한 효과를 나타내는 것을 확인하였다.나아가, 본 발명 실시예 1 및 2의 조성물을 포함하지 않는 비교예 1, 2 및 복합 필링 성분을 포함하지 않는 비교예 3 모두 본 발명에 비해 현저한 효과차이를 나타내어, 본 발명 화장료 조성물이 상기 성분들과 우수한 시너지 효과를 나타내는 것을 확인하였다.As shown in Table 4, when using the composition of Example 3 of the present invention, it was confirmed that a remarkably excellent whitening effect was observed, and it was confirmed to exhibit a superior effect than a whitening mist containing potassium alum on the market. Comparative Examples 1 and 2, which do not contain the composition of Inventive Examples 1 and 2, and Comparative Example 3 that does not contain the complex peeling component, all show a significant difference in effect compared to the present invention, so that the cosmetic composition of the present invention has excellent synergy with the above ingredients. It was confirmed that the effect was exhibited.
또한, 본 발명 실시예 3의 조성물은 비교예 및 대조군과 비교할 때 우수한 탄력 개선 효과를 나타내는 것을 확인하였으며, 실시예 1 및 2의 조성물을 하나 이상씩 함유하고 있는 비교예 1 내지 3 모두 대조군과 비교할 때 우수한 탄력 개선 효과를 나타내는 것을 확인하였다.In addition, it was confirmed that the composition of Example 3 of the present invention exhibits an excellent elasticity improvement effect when compared to the comparative examples and the control, and all of Comparative Examples 1 to 3 containing one or more compositions of Examples 1 and 2 were compared with the control group. When it was confirmed that it exhibits an excellent elasticity improvement effect.
제조예 1. 본 발명의 화장료 조성물을 함유하는 에센스 제조Preparation Example 1. Preparation of essence containing the cosmetic composition of the present invention
하기의 표 5와 같이 에센스 제형의 화장료 조성물을 제조하였다(단위: 중량%).As shown in Table 5 below, a cosmetic composition of an essence formulation was prepared (unit:% by weight).
제조예 2. 본 발명의 화장료 조성물을 함유하는 크림 제조Preparation Example 2. Preparation of a cream containing the cosmetic composition of the present invention
하기의 표 6과 같이 크림 제형의 화장료 조성물을 제조하였다(단위: 중량%).As shown in Table 6 below, a cream-formed cosmetic composition was prepared (unit:% by weight).
전술한 본 발명의 설명은 예시를 위한 것이며, 본 발명이 속하는 기술분야의 통상의 지식을 가진 자는 본 발명의 기술적 사상이나 필수적인 특징을 변경하지 않고서 다른 구체적인 형태로 쉽게 변형이 가능하다는 것을 이해할 수 있을 것이다. 그러므로 이상에서 기술한 실시예들은 모든 면에서 예시적인 것이며 한정적이 아닌 것으로 이해해야만 한다. 예를 들어, 단일형으로 설명되어 있는 각 구성 요소는 분산되어 실시될 수도 있으며, 마찬가지로 분산된 것으로 설명되어 있는 구성 요소들도 결합된 형태로 실시될 수 있다.본 발명의 범위는 후술하는 청구범위에 의하여 나타내어지며, 청구범위의 의미 및 범위 그리고 그 균등 개념으로부터 도출되는 모든 변경 또는 변형된 형태가 본 발명의 범위에 포함되는 것으로 해석되어야 한다.The above description of the present invention is for illustrative purposes only, and those of ordinary skill in the art to which the present invention pertains will be able to understand that other specific forms can be easily modified without changing the technical spirit or essential features of the present invention. will be. Therefore, it should be understood that the embodiments described above are illustrative and non-limiting in all respects. For example, each component described as a single type may be implemented in a distributed manner, and similarly, components described as being distributed can also be implemented in a combined form. The scope of the present invention is in the appended claims. It is represented by, and all changes or modifications derived from the meaning and scope of the claims and the concept of equivalents thereof should be construed as being included in the scope of the present invention.
Claims (5)
육두구(Nutmeg) 20 내지 50 중량부, 하늘타리(Chinese cucumber) 뿌리 20 내지 50 중량부, 흰무늬엉겅퀴(Silybum marianum) 씨 10 내지 40 중량부, 엘더플라워(Elder flower) 10 내지 40 중량부, 다마스크장미(Rosa Damascena) 꽃 10 내지 30 중량부, 라벤더꽃 10 내지 30 중량부, 클레리(Salvia Sclarea) 10 내지 30 중량부, 히아신스(Hyacinthus) 전초 1 내지 30 중량부, 마트리카리아(Matricaria chamomilla) 꽃 1 내지 30 중량부, 보리지(Borago officinalis) 1 내지 30 중량부 및 수레국화(Centaurea cyanus) 꽃 1 내지 30 중량부로부터 수득한 추출물; 및
베르가못(citrus aurantium bergamia, bergamot) 오일 1 내지 5 중량부, 티트리(Melaleuca alternifolia) 오일 1 내지 5 중량부, 오렌지(Citrus Aurantium Dulcis) 오일 1 내지 5 중량부 및 해바라기씨 오일 1 내지 30 중량부를 포함하여 제조된 것인, 화장료 조성물.1 part by weight of capryloyl salicylic acid (LHA), 1 part by weight of poly-alphahydroxy acid (PHA) and 0.3 part by weight of alpha hydroxy acid (AHA);
Nutmeg 20 to 50 parts by weight, Chinese cucumber root 20 to 50 parts by weight, Silybum marianum seeds 10 to 40 parts by weight, Elder flower 10 to 40 parts by weight, Damask Rose ( Rosa Damascena ) flowers 10 to 30 parts by weight, lavender flowers 10 to 30 parts by weight, Clary (Salvia Sclarea ) 10 to 30 parts by weight, Hyacinthus outpost 1 to 30 parts by weight, Matricaria chamomilla An extract obtained from 1 to 30 parts by weight of flowers, 1 to 30 parts by weight of Borago officinalis , and 1 to 30 parts by weight of a cornflower ( Centaurea cyanus) flower; And
Bergamot ( citrus aurantium bergamia , bergamot) oil 1 to 5 parts by weight, tea tree ( Melaleuca alternifolia ) oil 1 to 5 parts by weight, orange ( Citrus Aurantium Dulcis ) oil 1 to 5 parts by weight and sunflower seed oil 1 to 30 parts by weight included It is prepared by, a cosmetic composition.
상기 화장료 조성물은 피부 각질 제거 및 블랙헤드 개선용인 것인, 화장료 조성물.The method of claim 1,
The cosmetic composition is for removing dead skin cells and improving blackheads.
상기 화장료 조성물은 피부 보습, 피부 진정, 피부 미백 및 피부 탄력 개선 효과를 추가로 포함하는 것인, 화장료 조성물.The method of claim 4,
The cosmetic composition further comprises skin moisturizing, skin soothing, skin whitening and skin elasticity improvement effects.
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| KR1020200096857A KR102227355B1 (en) | 2020-08-03 | 2020-08-03 | Complex cosmetic composition for non-irritating weak acid exfoliation and epithelial cell nutrition |
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| KR1020200096857A KR102227355B1 (en) | 2020-08-03 | 2020-08-03 | Complex cosmetic composition for non-irritating weak acid exfoliation and epithelial cell nutrition |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| KR102227355B1 true KR102227355B1 (en) | 2021-03-11 |
Family
ID=75142975
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| KR1020200096857A Expired - Fee Related KR102227355B1 (en) | 2020-08-03 | 2020-08-03 | Complex cosmetic composition for non-irritating weak acid exfoliation and epithelial cell nutrition |
Country Status (1)
| Country | Link |
|---|---|
| KR (1) | KR102227355B1 (en) |
Cited By (4)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| KR102343166B1 (en) * | 2021-06-02 | 2021-12-28 | 주식회사 단정바이오 | Cosmetic composition having anti-oxidant, anti-inflammatory, skin soothing, regeneration, elasticity and moisturizing effects which comprise Melaleuca Alternifolia (Tea Tree) Leaf, Artemisia Princeps Leaf, Polygonum Fagopyrum (Buckwheat) Seed and Capryloyl Salicylic Acid |
| KR102351202B1 (en) * | 2021-11-05 | 2022-01-14 | 주식회사 레몬앰앤피 | Peeling cosmetic composition containing acacia honey-derived lapaglowacid, which removes hypoallergenic dead skin cells, improves skin tone-up effect, and improves oil-water moisture balance, and method for manufacturing the same |
| KR102472483B1 (en) * | 2022-01-14 | 2022-12-01 | 주식회사 한국화장품제조 | Cosmetic composition having exfoliating effect and moisturizing effect |
| KR102539377B1 (en) | 2022-11-02 | 2023-06-05 | 주식회사 제이피에스코스메틱 | Liquid type exfoliating cosmetic materials, Manufacturing method thereof and Cosmetics for exfoliating |
Citations (5)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| JP2003104835A (en) * | 2001-09-28 | 2003-04-09 | Ichimaru Pharcos Co Ltd | Cosmetic composition |
| KR100687468B1 (en) | 2005-08-30 | 2007-02-27 | 보령메디앙스 주식회사 | Cosmetic composition containing sprout vegetable fermented extract having immune enhancing and moisturizing effect |
| KR20100031068A (en) * | 2008-09-11 | 2010-03-19 | (주)바이오에프디엔씨 | Herb cosmetic composition for skin moisturizing and soothing and method for preparing the same |
| KR20170038685A (en) * | 2015-09-30 | 2017-04-07 | 존슨 앤드 존슨 컨수머 인코포레이티드 | Compositions and methods for treating blackheads |
| KR20180006455A (en) * | 2015-05-28 | 2018-01-17 | 시므라이즈 아게 | Cosmetic composition comprising ginger root extract |
-
2020
- 2020-08-03 KR KR1020200096857A patent/KR102227355B1/en not_active Expired - Fee Related
Patent Citations (5)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| JP2003104835A (en) * | 2001-09-28 | 2003-04-09 | Ichimaru Pharcos Co Ltd | Cosmetic composition |
| KR100687468B1 (en) | 2005-08-30 | 2007-02-27 | 보령메디앙스 주식회사 | Cosmetic composition containing sprout vegetable fermented extract having immune enhancing and moisturizing effect |
| KR20100031068A (en) * | 2008-09-11 | 2010-03-19 | (주)바이오에프디엔씨 | Herb cosmetic composition for skin moisturizing and soothing and method for preparing the same |
| KR20180006455A (en) * | 2015-05-28 | 2018-01-17 | 시므라이즈 아게 | Cosmetic composition comprising ginger root extract |
| KR20170038685A (en) * | 2015-09-30 | 2017-04-07 | 존슨 앤드 존슨 컨수머 인코포레이티드 | Compositions and methods for treating blackheads |
Cited By (4)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| KR102343166B1 (en) * | 2021-06-02 | 2021-12-28 | 주식회사 단정바이오 | Cosmetic composition having anti-oxidant, anti-inflammatory, skin soothing, regeneration, elasticity and moisturizing effects which comprise Melaleuca Alternifolia (Tea Tree) Leaf, Artemisia Princeps Leaf, Polygonum Fagopyrum (Buckwheat) Seed and Capryloyl Salicylic Acid |
| KR102351202B1 (en) * | 2021-11-05 | 2022-01-14 | 주식회사 레몬앰앤피 | Peeling cosmetic composition containing acacia honey-derived lapaglowacid, which removes hypoallergenic dead skin cells, improves skin tone-up effect, and improves oil-water moisture balance, and method for manufacturing the same |
| KR102472483B1 (en) * | 2022-01-14 | 2022-12-01 | 주식회사 한국화장품제조 | Cosmetic composition having exfoliating effect and moisturizing effect |
| KR102539377B1 (en) | 2022-11-02 | 2023-06-05 | 주식회사 제이피에스코스메틱 | Liquid type exfoliating cosmetic materials, Manufacturing method thereof and Cosmetics for exfoliating |
Similar Documents
| Publication | Publication Date | Title |
|---|---|---|
| KR102227355B1 (en) | Complex cosmetic composition for non-irritating weak acid exfoliation and epithelial cell nutrition | |
| KR102236253B1 (en) | Cosmetic composition for skin improvement comprising extracts derived from natural products and method for manufacturing the same | |
| KR20080065726A (en) | Skin protection cosmetic composition comprising a liquid crystal emulsified base blended with herbal extracts | |
| KR101915655B1 (en) | Cosmetic composition containing Croton Lechleri resin extract | |
| KR102104214B1 (en) | Cosmetic composition comprising potassium alum | |
| KR101155807B1 (en) | Cosmetic composition for moisturizing and firming the skin | |
| KR20120000251A (en) | Cosmetic composition containing kelp extract | |
| KR101189991B1 (en) | Cosmetic composition containing Opuntia coccinellifera, Betula Alba Juice, Extra virgin olive oil and polyol for moisturizing the skin | |
| KR101141802B1 (en) | Cosmetic composition for improving the male skin | |
| KR102162377B1 (en) | Extracts derived from natural products and cosmetic composition containing the same, and process for producing the same | |
| KR20110052095A (en) | Cosmetic composition for moisturizing skin containing mushroom extract | |
| KR101803271B1 (en) | Cosmetic composition for moisturizing or improving skin elasticity | |
| US20180353413A9 (en) | Skin compositions containing hydrocortisone | |
| KR20090009054A (en) | Cosmetic composition containing nanovegetal vitatox having antioxidant effect and wrinkle improvement | |
| US20230270660A1 (en) | Silybum marianum (L.) Gaertn. oil for reinforcing the barrier function of the skin | |
| KR20120139222A (en) | Composition for skin external application comprising tanshinone iia as the active ingredient | |
| KR20120009147A (en) | Moisturizing skin external composition containing baekhwasachocho extract | |
| KR101056756B1 (en) | Cosmetic composition containing herbal extract | |
| KR20110013000A (en) | Moisturizing cosmetic composition having an effect of relieving dryness and itching by removing dead skin cells and increasing moisture content | |
| KR20080111249A (en) | Cosmetics Containing Chia Seed Extract | |
| KR20130022476A (en) | A cosmetic composition containing extract of artemisia iwayomogi | |
| KR101934976B1 (en) | Composition for enhancing skin barrier comprising mixture of Diospyros lotus leaf extract and Curcuma longa extract as effective component | |
| KR101648466B1 (en) | Cosmetic composition for improving skin | |
| KR102541771B1 (en) | Cosmetic Composition For Moisturizing Skin Comprising Mixed Extracts of Chaenomeles sinensis fruit, Diospyros kaki leaf, Cinnamomum cassia bark, Artemisia princeps leaf, Chrysanthellum indicum and Camellia sinensis leaf as Active Ingredient | |
| KR100574233B1 (en) | Cosmetic composition containing plant extracts having skin moisturizing and anti-irritant effects |
Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| PA0109 | Patent application |
Patent event code: PA01091R01D Comment text: Patent Application Patent event date: 20200803 |
|
| PA0201 | Request for examination | ||
| PA0302 | Request for accelerated examination |
Patent event date: 20200811 Patent event code: PA03022R01D Comment text: Request for Accelerated Examination Patent event date: 20200803 Patent event code: PA03021R01I Comment text: Patent Application |
|
| PE0701 | Decision of registration |
Patent event code: PE07011S01D Comment text: Decision to Grant Registration Patent event date: 20201208 |
|
| GRNT | Written decision to grant | ||
| PR0701 | Registration of establishment |
Comment text: Registration of Establishment Patent event date: 20210308 Patent event code: PR07011E01D |
|
| PR1002 | Payment of registration fee |
Payment date: 20210308 End annual number: 3 Start annual number: 1 |
|
| PG1601 | Publication of registration | ||
| PC1903 | Unpaid annual fee |
Termination category: Default of registration fee Termination date: 20241219 |