KR102160726B1 - Uv-blocking and skin-moisturizing cosmetic composition containing nano collagen peptide chelate zinc - Google Patents

Abstract

The present invention relates to a UV-blocking and skin moisturizing cosmetic composition containing nano collagen peptide chelate zinc, zinc oxide (ZnO), and titanium dioxide (TiO_2).

Description

Sun protection and skin moisturizing cosmetic composition containing nano collagen peptide chelate zinc {UV-BLOCKING AND SKIN-MOISTURIZING COSMETIC COMPOSITION CONTAINING NANO COLLAGEN PEPTIDE CHELATE ZINC}

The present invention relates to a UV-blocking and skin moisturizing cosmetic composition containing zinc nano-collagen peptide chelate.

In general, collagen (Collagen) is also called light protein or collagen (膠原質) and is widely distributed in multicellular animals such as invertebrates and vertebrates, and is most often found quantitatively.

In mammals, collagen accounts for about one-third of the total protein and is a very strong light protein that makes up the connective tissue, and it transmits power from the tendons or ligaments without loss.

The basic structural unit of collagen is a tropocollagen with a molecular weight of about 300,000 (母膠原質). This molecule has a triple helix structure with a right twisted three-stranded polypeptide chain. Tropocollagen molecules associate to form collagen fibers (collagen fibers). Each molecule is arranged in an axial direction shifted by 1/4 to form a unique stripe spaced at 64 nm intervals, forming a bridge structure between the molecules along with the growth of animals. Becomes insoluble. However, if collagen is boiled for a long time in hot water, dilute acid, or dilute alkali, it turns into gelatin, a derived protein that dissolves in water.

Collagen Peptide is a type of fibrous protein composed of glycine, proline, hydroxyproline, glutamic acid, etc., and has a small amount of amino acids containing sulfur. It mainly exists in the membrane surrounding organs in the body, joint cartilage, cornea of the eye, bones and skin, and plays a very important role as a component of the dermal layer in the skin.

The main function of collagen is known for its firmness, tissue resistance and bonding, and support for cell adhesion. These collagens are known to be closely related to the formation of wrinkles in the skin due to aging and photoaging caused by UV irradiation.

With the rising income level and entering an aging society, extensive research on skin aging has progressed, revealing the function of collagen on the skin. Among them, retinoic acid, a substance that promotes collagen synthesis, is claimed that when collagen metabolism is activated by promoting the synthesis of collagen, the components of the dermal matrix increase, which can improve wrinkles, improve elasticity, strengthen skin, and heal wounds. ), TGF (transforming growth factor), animal-derived placenta, beturinic acid, and chlorella extract as cosmetic compositions for skin reinforcement have been widely released, but have not received much attention. In addition, many products containing collagen, which use collagen as a cosmetic composition for skin protection, are being sold, but it is pointed out that cosmetics applied to the skin surface are difficult to expect the skin moisturizing effect because transdermal absorption of collagen, a polymer, is difficult.

In recent years, collagen peptides are increasingly used as health foods, surgical or ophthalmic therapeutics or cosmetic additives. Meanwhile, for these collagen peptides, the stability of the product and the absorption rate in the skin and body are regarded as important in terms of food, pharmaceutical and cosmetic products.

Meanwhile, in recent years, interest in UV protection, which causes skin aging, skin cancer, and sunburn, has also increased. Accordingly, various products such as sunscreen containing sunscreen, sun stick, sun spray, BB cream, CC cream, and cushion are being released.

Sunscreens that can be included in these products are divided into organic sunscreens and inorganic sunscreens.

Organic sunscreens are ultraviolet absorbers that absorb ultraviolet rays from the skin's surface and disperse them as thermal energy. They have various absorption wavelengths and have little clouding, but may cause side effects that cause skin trouble.

Inorganic sunscreen is an ultraviolet scattering agent that scatters and reflects ultraviolet rays to prevent skin penetration, and has relatively good stability and high ultraviolet blocking power, but there is a problem of clouding.

And most recently released products such as sunscreen contain titanium dioxide (TiO2) and zinc oxide (ZnO), which are inorganic sunscreens.

However, such titanium dioxide (TiO2) and zinc oxide (ZnO) also have several disadvantages. For example, titanium dioxide (TiO2) and zinc oxide (ZnO) have a high refractive index and cause a white clouding phenomenon that makes the skin look white. In addition, titanium dioxide (TiO2) and zinc oxide (ZnO) are coated with different ingredients in order to prevent the composition of the formulation from being modified, but in this case, there is a problem that the product does not apply well to the skin due to the large particles.

Korean Registered Patent Publication No. 10-0488913 (2005.05.11) Korean Registered Patent Publication No. 10-1965202 (2019.04.03)

The present invention relates to a UV-blocking and skin moisturizing cosmetic composition containing zinc nano-collagen peptide chelate that can be used in cosmetics, etc., and has excellent preservation or stability of the product, and is chelated to collagen peptides as well as peptides in the skin or body. It is an object of the present invention to provide a UV-blocking and skin-moisturizing cosmetic composition containing zinc, a nano-collagen peptide chelate having excellent absorption and low whitening effect and excellent UV-blocking effect.

The present invention provides a sunscreen and skin moisturizing cosmetic composition comprising nano-collagen peptide chelate zinc, zinc oxide, and titanium dioxide.

The nano-collagen peptide chelate zinc of the present invention has an effect of preventing aging, discoloration and deterioration when used in food, and when used as a cosmetic, it increases the moisture content of the skin to maintain moisture and improve wrinkles.

In addition, the product is excellent in preservation or stability, and the absorption rate of zinc chelated to collagen peptide as well as collagen peptide in skin or body is excellent.

Hereinafter, the present invention will be described in more detail to aid understanding of the present invention. In this case, the terms or words used in the specification and claims should not be interpreted as being limited to a conventional or dictionary meaning, and the inventor appropriately defines the concept of the term in order to describe his own invention in the best way. It should be interpreted as a meaning and concept consistent with the technical idea of the present invention based on the principle that it can be done.

The present invention relates to a UV-blocking and skin moisturizing cosmetic composition containing zinc nano-collagen peptide chelate that can be used in cosmetics, etc., and has excellent preservation or stability of the product, and is chelated to collagen peptides as well as peptides in the skin or body. It is an object of the present invention to provide a UV-blocking and skin-moisturizing cosmetic composition containing zinc, a nano-collagen peptide chelate having excellent absorption and low whitening effect and excellent UV-blocking effect.

Specifically, the sunscreen and skin moisturizing cosmetic composition of the present invention includes Nano Collagen Peptide Chelate Zinc, zinc oxide (ZnO) and titanium dioxide (Titanium Dioxide, TiO ₂ ).

The sunscreen and skin moisturizing cosmetic composition of the present invention can reduce the content of zinc oxide and titanium dioxide, including the nano-collagen peptide chelate zinc, thereby reducing cloudiness while improving application and moisturizing power, and has UV protection. It has the advantage of not being reduced.

In addition, the nano-collagen peptide chelate zinc reflects, absorbs, and disperses ultraviolet rays that zinc oxide and titanium dioxide cannot block, thereby minimizing damage to skin tissues by ultraviolet rays.

Meanwhile, the UV protection and skin moisturizing cosmetic composition may include 0.01 to 30 parts by weight of zinc oxide chelate, 0.5 to 25 parts by weight of zinc oxide, and 0.5 to 25 parts by weight of titanium dioxide.

And the UV blocking and skin moisturizing cosmetic composition may further include at least one selected from 0.01 to 30 parts by weight of fish collagen and 0.01 to 30 parts by weight of phyto collagen.

And the sunscreen and skin moisturizing cosmetic composition may further include 0.5 to 10 parts by weight of bis-ethylhexyloxyphenolmethoxyphenyltriazine.

And the UV blocking and skin moisturizing cosmetic composition may further include 0.01 to 10 parts by weight of panthenol.

And the sunscreen and skin moisturizing cosmetic composition may further include 0.01 to 20 parts by weight of butylene glycol.

Collagen, also known as light protein or collagen, is widely distributed in multicellular animals such as invertebrates and vertebrates, and is the most quantitatively found light protein. It is the membrane that surrounds organs in the human body, joint cartilage, and eyes. It mainly exists in the cornea, bones and skin, and plays a very important role as a component of the dermal layer in the skin. The main function of collagen is known for its firmness, tissue resistance and bonding, and support for cell adhesion.

Collagen can be largely divided into animal collagen such as cattle skin and pork skin, vegetable collagen such as fruits, vegetables, seeds, nuts, mushrooms, and marine collagen such as seaweed, fish, fish scale, and fish skin, and the nano collagen peptide chelate zinc (Nano Collagen Peptide Chelate Zinc) is characterized in that the collagen used in the production is at least one selected from the group consisting of animal collagen, vegetable collagen, and marine collagen.

Collagen is commonly referred to as collagen. Collagen is a fibrous protein found in most animals, especially mammals, and occupies most of all connective tissues in the body, such as skin and cartilage. Collagen has a triple helix structure in which three polypeptide chains are twisted, and the average molecular weight of collagen is 300,000 Da (Dalton, Dalton), which is large.

In the present invention, the preparation of nano-collagen peptide chelate zinc to increase the skin absorption rate of nano-collagen peptide chelate zinc is first 1) hydrolysis reaction by adding enzyme to collagen to form collagen peptide (hereinafter referred to as'collagen nano-ization step') )do.

Accordingly, the average molecular weight of the collagen peptide of the present invention is 200 Da to 600 Da, more specifically 300 Da to 400 Da, and its size is 0.1 nm to 10 nm, more specifically 1 nm to 5 nm. Bar, due to its small molecular weight and small size, it shows the effect of being quickly absorbed into the skin.

The enzyme used in the collagen nano-ization step is a proteolytic enzyme, characterized in that it contains at least one selected from the group consisting of collagenase, trypsin, papain, pepsin, and alcalase, and decomposes collagen into collagen peptides. The hydrolysis reaction is characterized in that it is carried out at 50° C. to 70° C., more specifically 50° C. to 60° C. for 2 to 24 hours.

When the hydrolysis reaction occurs under the above range of temperature and time conditions, it is possible to obtain a collagen peptide having an appropriate molecular weight and size with high absorption rate in the body.

After the collagen nano-ization step, the nano-collagen peptide chelate zinc 2) is formed by adding zinc to the collagen peptide (hereinafter, also referred to as'collagen peptide chelation step').

In the collagen peptide chelation step of the present invention, the terminal group of the amino acid is made from NH ²⁺ to NH ³⁺ to form a covalent bond, while ionic bonds in the form of adding zinc instead of H ions of the COOH group are performed to stabilize. And zinc is characterized in that 1 to 20 parts by weight relative to 100 parts by weight of the collagen peptide, and within the above range, nano-collagen peptide chelate zinc can be obtained with high purity without unreacted zinc.

The chelate refers to a bond when a ligand having a plurality of coordination groups coordinating with a metal ion in one molecule is coordinating with a metal, or a complex formed by the bond. In the present invention, an unshared electron pair that does not participate in the covalent bond of an amino group bonded to the alpha carbon of an amino acid forms a complete coordination bond with zinc to form a nano-collagen peptide chelate zinc.

The present invention can improve the preservation or stability of the product through the chelation of the collagen peptide and zinc, and can exhibit the effect of improving the absorption rate of zinc together with the collagen peptide in the skin.

Thereafter, the nano-collagen peptide chelate zinc of the present invention may be prepared through one or more steps selected from the group consisting of a purification step, a sterilization step and a drying step.

High purity nano-collagen peptide chelate zinc can be prepared through the purification step. The purification step may be performed by filtering and separating a high molecular weight or large-sized collagen peptide that is not hydrolyzed to an appropriate molecular weight and size by a collagen nano-ization step, unreacted enzymes, zinc, and by-products.

In addition, in the sterilization step, microorganisms harmful to the human body may be removed through physical or chemical treatment of the nanocollagen peptide chelate zinc. It can be added to heat-resistant appliances (glassware, ceramics, some metal products, etc.) and heated at 70°C to 90°C for 1 hour and 5 hours to dry heat sterilization of harmful microorganisms and bacteria.

In addition, in the drying step, the zinc nano-collagen peptide chelate may be dried using a dryer.

The nano-collagen peptide chelate zinc prepared through the above steps is represented by the following formula (1).

[Formula 1]

(Where M means Zn.)

The nano-collagen peptide chelate zinc of the present invention can be quickly absorbed into the skin together with chelated zinc within 1 hour, more specifically 30 minutes.When applied for a long period of time, compared to other collagen products, skin moisturizing, elasticity, It can show an excellent effect in improving wrinkles.

Zinc oxide (ZnO) and titanium dioxide (TiO ₂ ) are inorganic UV blockers that reflect/scatter ultraviolet rays, and their energy bend gaps are 3.0ev and 3.2ev, respectively. The blocking rate is high, but the blocking rate of UVA1 of 340 nm to 400 nm is low.

Fish Collagen is a low-molecular collagen mainly extracted from fish skins such as pollock, skate, and salmon. Fish from which fish collagen is extracted is not limited, and any fish can be used as long as fish collagen can be extracted.

Phyto collagen is an amino acid complex extracted from plant proteins, and is characterized by being composed of amino acids with a high content of oxyproline among amino acids contained in plants. Phyto collagen is mainly included in a cosmetic composition and is absorbed into the skin, thereby improving skin elasticity and exhibiting excellent skin moisturizing effect.

Bis-Ethylhexyloxyphenol Methoxyphenyl Triazine (Bis-Ethylhexyloxyphenol Methoxyphenyl Triazine) shows the characteristics of both organic and inorganic sunscreens, and is a component that absorbs, reflects, and disperses ultraviolet rays and can stably block UVA and UVB. have.

Panthenol is an alcohol derivative of pantothenic acid. When absorbed into the skin, it is oxidized to become pantothenic acid. This panthenol is known to have effects such as collagen formation, skin regeneration, oil suppression, and inflammation suppression in the body.

Butylene glycol is a component made from a substance derived from fatty acids extracted by fermentation of sugar cane. It attracts moisture and has a moisturizing effect.

Hereinafter, embodiments of the present invention will be described in detail so that those skilled in the art can easily implement the present invention. However, the present invention may be implemented in various different forms, and is not limited to the embodiments described herein.

Example 1

The marine collagen of fish skin and jellyfish was washed with purified water to remove impurities, and 4 liters of purified water were added to 1 kg of raw materials and pulverized to 50 μm with a chopper. Thereafter, the deodorized raw material was passed through ozone into a 0.5% solution of citric acid, and 0.5 w% of pepsin protease was added and hydrolyzed at 55° C. for 24 hours to have a molecular weight of 300 Da to 400 Da and a size of 1 nm to 5 nm A collagen peptide was obtained.

For the preparation of the nano-collagen peptide chelate zinc, zinc sulfate was added in parts by weight so that the zinc content was 1 to 20 parts by weight based on 100 weight of the collagen peptide, and a chelating reaction was carried out while enzymatic hydrolysis at 55°C. It was dried using a spray dryer to prepare a zinc collagen peptide chelate complex powder.

Comparative Example 1

In Example 1, a collagen peptide powder was prepared in the same manner as in Example 1, except that zinc sulfate was not added.

Experimental Example 1

Using the collagen peptides of Example 1 and Comparative Example 1, a cream as shown in Table 3 was prepared and tested to see if it had a skin moisturizing effect, a UV blocking effect, and an anti-wrinkle effect.

Furtherance Weight ratio (% by weight)
Example 1 Comparative Example 1 Nano collagen peptide 5% 5% Zinc oxide 5% 5% Titanium dioxide 5% 5% Phyto Collagen 2.5% 2.5% Fish collagen 2.5% 2.5% Bis-ethylhexyloxyphenolmethoxyphenyltriazine One% One% Panthenol One% One% Butylene Clycol 10% 10% Purified water 68% 68%

(In Table 1, phyto collagen and fish collagen were hydrolyzed to use those having a molecular weight of 300 Da to 400 Da and a size of 1 nm to 5 nm.)

1-1) Skin moisture content measurement

In order to determine the moisturizing effect of the skin, the skin moisture content was measured using a measuring device (IMPEDANCE METER, SKICON-200 IBS JAPAN). About 1 ml of a sample was applied, the remaining liquid was removed after 30 minutes, and the electrical conductivity of the skin was measured every elapsed time, and the results are shown in Table 2 below.

division
(Unit: Ω) 0
(sec) 30
(sec) 60
(sec) 150
(sec) 240
(sec) 330
(sec) 420
(sec) 510
(sec) Example 1 135 1599 630 400 330 320 300 290 Comparative Example 1 125 1050 240 125 125 120 115 105 Purified water 80 800 180 120 115 110 80 60

As shown in Table 2, the moisturizing properties were high in the order of Example 1> Comparative Example 1> purified water. Through this, it was found that the nutritional cream to which the chelate complex of zinc collagen peptide of Example 1 was added has excellent moisturizing properties.

1-2) UV blocking experiment

In order to determine the UV protection effect, the UV protection index was measured 10 times for the cream of Example 1 and the cream of Comparative Example 1 using a UV protection index analyzer (SPF analyzer 290S, Laser componets, UK), and the average value was measured. . The results are shown in Table 3 below.

Sun protection factor (SPF) Example 1 23.2 Comparative Example 1 18.8

As can be seen in Table 3, Example 1 showed a higher SPF value of 4.4 than that of Comparative Example 1. The nano-collagen peptide chelate zinc appears to enhance the UV-blocking effect.

1-3) Wrinkle improvement experiment

30 women in their 50s were randomly divided into a first group and a second group, and in the first group, the cream of Example 1 was applied to the eye area twice every morning/evening for 2 months, and the second group was a comparative example. The results of examining whether the wrinkles around the eyes are improved by applying the cream of 1 to the eye area twice every morning/evening for 2 months are shown in Table 4 below.

No improvement Slightly improved Medium improvement Significant improvement Group 1 0 One 3 11 Group 2 0 4 5 6

The second group to which the cream of Comparative Example 1 was applied also showed some improvement in wrinkles around the eyes, but in the first group to which the cream of Example 1 was applied, a significant improvement was observed in 11 people. Through this, it was confirmed that the cream of Example 1 was excellent in improving wrinkles.

The above description of the present invention is for illustrative purposes only, and those of ordinary skill in the art to which the present invention pertains will be able to understand that it can be easily modified into other specific forms without changing the technical spirit or essential features of the present invention. will be. Therefore, it should be understood that the embodiments described above are illustrative in all respects and not limiting.

Claims (7)

UV protection and skin moisturizing cosmetic composition comprising nano collagen peptide chelate zinc, zinc oxide and titanium dioxide.
The method according to claim 1,
Sunscreen and skin moisturizing cosmetic composition comprising 0.01 to 30 parts by weight of zinc nano-collagen peptide chelate, 0.5 to 25 parts by weight of zinc oxide, and 0.5 to 25 parts by weight of titanium dioxide.
The method according to claim 2,
Sunscreen and skin moisturizing cosmetic composition further comprising 0.01 to 30 parts by weight of fish collagen.
The method according to claim 2,
UV protection and skin moisturizing cosmetic composition further comprising 0.01 to 30 parts by weight of phyto collagen.
The method according to claim 2,
A sunscreen and skin moisturizing cosmetic composition further comprising 0.5 to 10 parts by weight of bis-ethylhexyloxyphenol methoxyphenyltriazine.
The method according to claim 2,
UV protection and skin moisturizing cosmetic composition further comprising 0.01 to 10 parts by weight of panthenol.
The method according to claim 2,
Sunscreen and skin moisturizing cosmetic composition further comprising 0.01 to 20 parts by weight of butylene glycol.