KR102038487B1 - 텔로머라제 펩티드를 포함하는 항균 또는 항진균용 조성물 - Google Patents
텔로머라제 펩티드를 포함하는 항균 또는 항진균용 조성물 Download PDFInfo
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- KR102038487B1 KR102038487B1 KR1020120104178A KR20120104178A KR102038487B1 KR 102038487 B1 KR102038487 B1 KR 102038487B1 KR 1020120104178 A KR1020120104178 A KR 1020120104178A KR 20120104178 A KR20120104178 A KR 20120104178A KR 102038487 B1 KR102038487 B1 KR 102038487B1
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Abstract
본 발명은 서열 번호 1의 서열을 갖는 펩티드, 서열 번호 1의 서열의 단편인 펩티드 또는 상기 펩티드 서열과 80% 이상의 서열 상동성을 갖는 펩티드를 유효 성분으로 포함하는 항균 또는 항진균용 조성물을 개시한다.
Description
본 발명은 항균 활성을 가지는 텔로머라제 펩티드를 포함하는 조성물에 관한 것이다.
텔로미어(telomere)는 염색체의 말단에 반복적으로 존재하는 유전 물질로서, 해당 염색체의 손상이나 다른 염색체와의 결합을 방지한다고 알려져 있다. 세포가 분열할 때마다 텔로미어의 길이는 조금씩 짧아지는데, 일정한 횟수 이상의 세포 분열이 있게 되면 텔로미어는 매우 짧아지고, 그 세포는 분열을 멈추고 죽게 된다. 반면 텔로미어를 길게 하면 세포의 수명이 연장된다고 알려져 있으며, 그 예로 암세포에서는 텔로머라제(telomerase)라는 효소가 분비되어 텔로미어가 짧아지는 것을 막기 때문에, 암세포가 죽지 않고 계속 증식할 수 있다고 알려져 있다.
본 발명은 펩티드를 포함하여 뛰어난 항균 또는 항진균 활성을 가지는 조성물을 제공하고자 한다.
본 발명의 일측면은 서열 번호 1의 서열을 갖는 펩티드, 서열 번호 1의 서열의 단편인 펩티드 또는 상기 펩티드 서열과 80% 이상의 서열 상동성을 갖는 펩티드를 유효 성분으로 포함하는 항균,또는 항진균용 조성물을 제공한다.
서열 번호 1의 서열을 갖는 펩티드, 서열 번호 1의 서열의 단편인 펩티드 또는 상기 펩티드 서열과 80% 이상의 서열 상동성을 갖는 펩티드는 우수한 균 활성 억제 효과를 가지므로, 이를 포함하는 조성물은 항균 또는 항진균용으로 사용될 수 있다. 또한 본 발명의 일측면에 따른 서열 번호 1의 서열을 갖는 펩티드, 서열 번호 1의 서열의 단편인 펩티드 또는 상기 펩티드 서열과 80% 이상의 서열 상동성을 갖는 펩티드는 세포 내 독성이 낮아 생체 내 안정성이 높으므로, 유용하게 활용될 수 있다.
도 1은 농도별 pep 1의 E. coli에 대한 항균력을 나타낸 그래프이다.
도 2는 농도별 pep 1의 E. floccosum에 대한 항균력을 나타낸 그래프이다.
도 3은 농도별 pep 1의 T. mentargophytes에 대한 항균력을 나타낸 그래프이다.
도 2는 농도별 pep 1의 E. floccosum에 대한 항균력을 나타낸 그래프이다.
도 3은 농도별 pep 1의 T. mentargophytes에 대한 항균력을 나타낸 그래프이다.
거의 모든 고등 생물이 병원성 미생물에 대한 방어 수단으로서 면역 체계와 별도의 항균 펩티드를 체내에 축적하거나 분비하는 것으로 알려졌다. 현재까지 약 2,000 종 이상의 항균 펩티드가 발견되었으며, 이들 펩티드들은 발견된 종마다 그 아미노산 조성이 상이하지만 항균 작용 기작은 유사한 것으로 알려지고 있다.
항균 펩티드가 항균력을 나타내는 작용 기작은 크게 두 가지로 분류된다.
첫째, 항균 펩티드가 균의 세포막의 투과성을 증가시켜 막 전위를 파괴하고 세포대사를 멈추게 하는 작용 기작을 통해 항균력을 나타낸다. 기존에 알려진 대부분의 항균 펩티드가 이러한 작용 기작을 나타내는 것으로 알려져 있다.
둘째, 항균 펩티드가 균 세포 내로 침투하여 DNA 또는 RNA와 결합하여 전사(transcription) 또는 번역(translation)을 억제하는 작용 기작을 통해 항균력을 나타낼 수도 있다. 이와 같은 기작은 매우 강력한 작용 기작으로서 이와 같은 작용 기작을 갖는 펩티드는 강력한 항균 효과를 갖는다. 그러나, 현재 이와 같은 작용 기작을 하는 펩티드에 대한 연구는 거의 전무한 상태이다.
상기 항균 펩티드들은, 첫째, 광범위한 미생물에 대하여 강력한 항균력을 가지며, 둘째, 숙주 세포는 파괴하지 않으면서 외부에서 침입한 병원균에만 작용하여 인체에 무해한 항생 물질로서 작용하며, 셋째, 미생물의 내성 유발이 문제시되고 있는 종래의 항생제와는 전혀 다른 활성 기작으로 항균 활성을 나타내므로 내성 유발 가능성이 적고, 넷째, 글리코실레이션(glycosylation)과 같은 2차 변형(secondary modification)이 없기 때문에 유전자 조작을 통하여 대량 생산할 수 있으며, 다섯째, 열, 산 또는 알칼리 등에 강한 이화학적 안정성을 가지고 있기 때문에 제약 및 식품 분야에서의 산업적 이용성이 매우 크다는 장점을 갖는다.
본 발명의 일측면은 서열 번호 1의 서열을 갖는 펩티드, 서열 번호 1의 서열의 단편인 펩티드 또는 상기 펩티드 서열과 80% 이상의 서열 상동성을 갖는 펩티드의 항균 펩티드를 제공한다. 서열 번호 1의 서열을 갖는 펩티드, 서열 번호 1의 서열의 단편인 펩티드 또는 상기 펩티드 서열과 80% 이상의 서열 상동성을 갖는 펩티드는 균 세포 내로 침투하여 DNA 또는 RNA와 결합하여 전사(transcription) 또는 번역(translation)을 억제하는 작용 기작을 통해 항균력을 나타낸다.
본 발명의 일측면은 서열 번호 1의 서열을 갖는 펩티드, 서열 번호 1의 서열의 단편인 펩티드 또는 상기 펩티드 서열과 80% 이상의 서열 상동성을 갖는 펩티드를 유효 성분으로 포함하는 항균 또는 항진균용 조성물을 제공한다.
본 명세서에 개시된 펩티드는 서열 번호 1의 서열을 갖는 펩티드 또는 서열 번호 1의 서열의 단편인 펩티드와, 80% 이상, 85% 이상, 90% 이상 또는 95% 이상의 서열 상동성을 갖는 펩티드를 포함할 수 있다. 또한, 본 명세서에 개시된 펩티드는 서열 번호 1 내지 56 중 어느 한 서열을 포함하는 펩티드와, 1개 이상의 아미노산, 2개 이상의 아미노산, 3개 이상의 아미노산, 4개 이상의 아미노산이 다른 펩티드를 포함할 수 있다.
본 명세서에 개시된 펩티드는 자연 그대로의 공급원으로부터 동정 및 분리된 야생형 펩티드일 수 있다. 한편, 본 명세서에 개시된 펩티드는 서열 번호 1의 서열을 갖는 펩티드 또는 서열 번호 1의 서열의 단편인 펩티드와 비교하여 하나 이상의 아미노산이 치환, 결실 및/또는 삽입된 아미노산 서열을 포함하는, 인공 변이체일 수 있다. 인공 변이체에서뿐만 아니라 야생형 폴리펩티드에서의 아미노산 변화는 단백질의 폴딩(folding) 및/또는 활성에 유의한 영향을 미치지 않는 보존성 아미노산 치환을 포함한다. 보존성 치환의 예들은 염기성 아미노산(아르기닌, 리신 및 히스티딘), 산성 아미노산(글루탐산 및 아스파르트산), 극성 아미노산(글루타민 및 아스파라긴), 소수성 아미노산(루신, 이소로이신, 발린 및 메티오닌), 방향족 아미노산(페닐알라닌, 트립토판 및 티로신), 및 작은 아미노산(글리신, 알라닌, 세린 및 트레오닌)의 군의 범위 내에 있다. 일반적으로 특이적 활성을 변경시키지 않는 아미노산 치환이 본 분야에 공지되어 있다. 가장 흔하게 발생하는 교환은 Ala/Ser, Val/Ile, Asp/Glu, Thr/Ser, Ala/Gly, Ala/Thr, Ser/Asn, Ala/Val, Ser/Gly, Tyr/Phe, Ala/Pro, Lys/Arg, Asp/Asn, Leu/Ile, Leu/Val, Ala/Glu, 및 Asp/Gly, 그리고 이들과 반대인 것들이다.
본 발명의 일측면에서, 아미노산 변화는 펩티드의 물리 화학적 특성이 변경되도록 하는 성질에 속한다. 예를 들어, 펩티드의 열 안정성을 향상시키고, 기질 특이성을 변경시키고, 최적의 pH를 변화시키는 등의 아미노산 변화가 수행될 수 있다.
본 발명의 일측면에서, 서열 번호 1의 서열을 갖는 펩티드, 서열 번호 1의 서열의 단편인 펩티드 또는 상기 펩티드 서열과 80% 이상의 서열 상동성을 갖는 펩티드는, 30개 이하의 아미노산으로 구성될 수 있다. 본 발명의 다른 일측면에서, 서열 번호 1의 서열을 갖는 펩티드, 서열 번호 1의 서열의 단편인 펩티드 또는 상기 펩티드 서열과 80% 이상의 서열 상동성을 갖는 펩티드는, 서열 번호 2 내지 56 중 어느 한 서열 또는 상기 서열과 80% 이상의 서열 상동성을 갖는 서열을 포함하는 펩티드일 수 있다. 본 발명의 다른 일측면에서, 서열 번호 1의 서열을 갖는 펩티드, 서열 번호 1의 서열의 단편인 펩티드 또는 상기 펩티드 서열과 80% 이상의 서열 상동성을 갖는 펩티드는, 서열 번호 2 내지 56 중 어느 한 서열 또는 상기 서열과 80% 이상의 서열 상동성을 갖는 서열로 구성될 수 있다.
본 발명의 일측면에서, 서열 번호 1의 서열을 갖는 펩티드, 서열 번호 1의 서열의 단편인 펩티드 또는 상기 펩티드 서열과 80% 이상의 서열 상동성을 갖는 펩티드는 텔로머라제, 구체적으로 인간(Homo sapiens) 텔로머라제에서 유래한 펩티드를 포함한다.
서열 번호 1 내지 56에 기재된 펩티드는 아래 표 1 및 2와 같다. 아래 표 1 및 2의 "이름"은 각 펩티드들을 구별하기 위해 명명한 것이다. 본 발명의 일측면에서, 서열 번호 1에 기재된 펩티드는 인간 텔로머라제의 전체 펩티드를 나타낸다. 본 발명의 또 다른 일측면에서, 서열 번호 1 내지 56에 기재된 펩티드 중 하나 이상은 텔로머라제에 포함된 펩티드 중 해당 위치의 펩티드를 선별해 합성한 "합성 펩티드"를 포함한다.
| 서열번호 | 이름 | 텔로머라제 상 위치 | 서열 | 길이 |
| 1 | [1-1132] | MPRAPRCRAVRSLLRSHYREVLPLATFVRRLGPQGWRLVQRGDPAAFRALVAQCLVCVPWDARPPPAAPSFRQVSCLKELVARVLQRLCERGAKNVLAFGFALLDGARGGPPEAFTTSVRSYLPNTVTDALRGSGAWGLLLRRVGDDVLVHLLARCALFVLVAPSCAYQVCGPPLYQLGAATQARPPPHASGPRRRLGCERAWNHSVREAGVPLGLPAPGARRRGGSASRSLPLPKRPRR GAAPEPERTPVGQGSWAHPGRTRGPSDRGFCVVSPARPAEEATSLEGALSGTRHSHPSVGRQHHAGPPSTSRPPRPWDTPCPPVYAETKHFLYSSGDKEQLRPSFLLSSLRPSLTGARRLVETIFLGSRPWMPGTPRRLPRLPQRYWQMRPLFLELLGNHAQCPYGVLLKTHCPLRAAVTPAAGVCAREKPQGSVAAPEEEDTDPRRLVQLLRQHSSPWQVYGFVRACLRRLVPPGLWGSRHNERRFLRNTKKFISLGKHAKLSLQELTWKMSVRDCAWLRRSPGVGCVPAAEHRLREEILAKFLHWLMSVYVVELLRSFFYVTETTFQKNRLFFYRKSVWSKLQSIGIRQHLKRVQLRELSEAEVRQHREARPALLTSRLRFIPKPDGLRPIVNMDYVVGARTFRREKRAERLTSRVKALFSVLNYERARRPGLLGASVLGLDDIHRAWRTFVLRVRAQDPPPELYFVKVDVTGAYDTIPQDRLTEVIASIIKPQNTYCVRRYAVVQKAAHGHVRKAFKSHVSTLTDLQPYMRQFVAHLQETSPLRDAVVIEQSSSLNEASSGLFDVFLRFMCHHAVRIRGKSYVQCQGIPQGSILSTLLCSLCYGDMENKLFAGIRRDGLLLRLVDDFLLVTPHLTHAKTFLRTLVRGVPEYGCVVNLRKTVVNFPVEDEALGGTAFVQMPAHGLFPWCGLLLDTRTLEVQSDYSSYARTSIRASLTFNRGFKAGRNMRRKLFGVLRLKCHSLFLDLQVNSLQTVCTNIYKILLLQAYRFHACVLQLPFHQQVWKNPTFFLRVISDTASLCYSILKAKNAGMSLGAKGAAGPLPSEAVQWLCHQAFLLKLTRHRVTYVPLLGSLRTAQTQLSRKLPGT TLTALEAAANPALPSDFKTILD |
1132 aa | |
| 2 | pep1 | [611-626] | EARPALLTSRLRFIPK | 16 aa |
| 3 | pep2 | [660-689] | ALFSVLNYERARRPGLLGASVLGLDDIHRA | 30 aa |
| 4 | pep3 | [663-677] | SVLNYERARRPGLLG | 15 aa |
| 5 | pep4 | [674-683] | GLLGASVLGL | 10 aa |
| 6 | pep5 | [615-624] | ALLTSRLRFI | 10 aa |
| 7 | pep6 | [613-621] | RPALLTSRL | 9 aa |
| 8 | pep7 | [653-661] | RLTSRVKAL | 9 aa |
| 9 | pep8 | [691-705] | RTFVLRVRAQDPPPE | 15 aa |
| 10 | pep9 | [653-667] | RLTSRVKALFSVLNY | 15 aa |
| 11 | pep10 | [651-665] | AERLTSRVKALFSVL | 15 aa |
| 12 | pep11 | [667-675] | YERARRPGL | 9 aa |
| 13 | pep12 | [675-683] | LLGASVLGL | 9 aa |
| 14 | pep13 | [680-689] | VLGLDDIHRA | 10 aa |
| 15 | pep14 | [677-686] | GASVLGLDDI | 10 aa |
| 16 | pep15 | [660-669] | ALFSVLNYER | 10 aa |
| 17 | pep16 | [663-672] | SVLNYERARR | 10 aa |
| 18 | pep17 | [679-688] | SVLGLDDIHR | 10 aa |
| 19 | pep18 | [662-671] | FSVLNYERAR | 10 aa |
| 20 | pep19 | [666-675] | NYERARRPGL | 10 aa |
| 21 | pep20 | [667-676] | YERARRPGLL | 10 aa |
| 22 | pep21 | [672-681] | RPGLLGASVL | 10 aa |
| 23 | pep22 | [668-676] | ERARRPGLL | 9 aa |
| 24 | pep23 | [680-688] | VLGLDDIHR | 9 aa |
| 25 | pep24 | [663-671] | SVLNYERAR | 9 aa |
| 26 | pep25 | [664-672] | VLNYERARR | 9 aa |
| 27 | pep26 | [670-678] | ARRPGLLGA | 9 aa |
| 28 | pep27 | [673-681] | PGLLGASVL | 9 aa |
| 29 | pep28 | [671-679] | RRPGLLGAS | 9 aa |
| 30 | pep29 | [660-668] | ALFSVLNYE | 9 aa |
| 31 | pep30 | [674-682] | GLLGASVLG | 9 aa |
| 32 | pep31 | [679-687] | SVLGLDDIH | 9 aa |
| 33 | pep32 | [668-675] | ERARRPGL | 8 aa |
| 34 | pep33 | [670-677] | ARRPGLLG | 8 aa |
| 35 | pep34 | [674-681] | GLLGASVL | 8 aa |
| 36 | pep35 | [669-676] | RARRPGLL | 8 aa |
| 37 | pep36 | [676-683] | LGASVLGL | 8 aa |
| 38 | pep37 | [563-577] | VTETTFQKNRLFFYR | 15 aa |
| 39 | pep38 | [573-587] | LFFYRKSVWSKLQSI | 15 aa |
| 40 | pep39 | [583-597] | KLQSIGIRQHLKRVQ | 15 aa |
| 41 | pep40 | [603-617] | EAEVRQHREARPALL | 15 aa |
| 42 | pep41 | [613-627] | RPALLTSRLRFIPKP | 15 aa |
| 43 | pep42 | [623-637] | FIPKPDGLRPIVNMD | 15 aa |
| 44 | pep43 | [643-657] | RTFRREKRAERLTSR | 15 aa |
| 45 | pep45 | [683-697] | LDDIHRAWRTFVLRV | 15 aa |
| 46 | pep46 | [693-707] | FVLRVRAQDPPPELY | 15 aa |
| 47 | pep47 | [721-735] | PQDRLTEVIASIIKP | 15 aa |
| 48 | pep48 | [578-592] | KSVWSKLQSIGIRQH | 15 aa |
| 49 | pep49 | [593-608] | LKRVQLRELSEAEVRQ | 16 aa |
| 50 | pep-RIA-84 | [611-619] | EARPALLTS | 9 aa |
| 51 | pep-RIA-97 | [618-626] | TSRLRFIPK | 9 aa |
| 52 | pep-RIA-114 | [612-620] | ARPALLTSR | 9 aa |
| 53 | pep-RIA-132 | [614-622] | PALLTSRLR | 9 aa |
| 54 | pep-RIA-140 | [615-623] | ALLTSRLRF | 9 aa |
| 55 | pep-RIA-147 | [616-624] | LLTSRLRFI | 9 aa |
| 56 | pep-RIA-153 | [617-625] | LTSRLRFIP | 9 aa |
본 발명의 일측면은 서열 번호 1의 서열을 갖는 펩티드, 서열 번호 1의 서열의 단편인 펩티드 또는 상기 펩티드 서열과 80% 이상의 서열 상동성을 갖는 펩티드를 유효 성분으로 포함하는 항균 또는 항진균용 약학 조성물을 제공한다. 본 발명의 일측면에 따른 약학 조성물은 서열 번호 1의 서열을 갖는 펩티드, 서열 번호 1의 서열의 단편인 펩티드 또는 상기 펩티드 서열과 80% 이상의 서열 상동성을 갖는 펩티드를 유효 성분으로 포함하여 뛰어난 항균, 항진균 효과를 가지므로, 병원균에 기인한 각종 질환 및 증상을 예방 또는 치료할 수 있다.
본 발명의 일측면은 서열 번호 1의 서열을 갖는 펩티드, 서열 번호 1의 서열의 단편인 펩티드 또는 상기 펩티드 서열과 80% 이상의 서열 상동성을 갖는 펩티드의 항균, 항진균 용도를 제공한다.
본 발명의 일측면은 서열 번호 1의 서열을 갖는 펩티드, 서열 번호 1의 서열의 단편인 펩티드 또는 상기 펩티드 서열과 80% 이상의 서열 상동성을 갖는 펩티드, 또는 이를 포함하는 조성물을 대상에게 적용하는 것을 포함하는 병원균 감염의 예방 또는 치료 방법을 제공한다.
본 발명의 일측면은 서열 번호 1의 서열을 갖는 펩티드, 서열 번호 1의 서열의 단편인 펩티드 또는 상기 펩티드 서열과 80% 이상의 서열 상동성을 갖는 펩티드, 또는 이를 포함하는 조성물; 및 펩티드 또는 이를 포함하는 조성물의 투여량, 투여 경로, 투여 횟수 및 적응증 중 하나 이상을 개시한 지시서를 포함하는 항균 또는 항진균용 키트를 제공한다.
본 발명의 일측면은 서열 번호 1의 서열을 갖는 펩티드, 서열 번호 1의 서열의 단편인 펩티드 또는 상기 펩티드 서열과 80% 이상의 서열 상동성을 갖는 펩티드를 유효 성분으로 포함하는 항균 또는 항진균용 피부 외용제, 또는 화장료 조성물을 제공한다.
본 발명의 일측면은 서열 번호 1의 서열을 갖는 펩티드, 서열 번호 1의 서열의 단편인 펩티드 또는 상기 펩티드 서열과 80% 이상의 서열 상동성을 갖는 펩티드를 유효 성분으로 포함하는 항균 또는 항진균용 식품 조성물을 제공한다.
본 명세서에서 "항균 활성"이라 함은 미생물 세포를 죽이거나 그 성장을 억제할 수 있는 활성으로서 정의된다. 본 발명의 문맥에서, "항균" 이라 함은 살균 및/또는 정균 및/또는 살진균 및/또는 정진균 효과가 있다는 의미이다. "살균"은 세균, 곰팡이, 또는 효모나 조류(algae) 등의 하등 진핵생물, 원생생물 등의 세포를 죽일 수 있다는 것을 의미하며, "정균"은 세균, 효모 등의 하등 진핵생물, 원생생물 또는 곰팡이의 성장 억제, 즉 세균, 효모 등의 하등 진핵생물, 원생생물 또는 곰팡이 세포의 성장을 억제할 수 있다는 것을 의미한다. "살진균" 이라 함은 진균 세포를 죽일 수 있다는 것을 의미한다. 용어 "정진균"은 진균 성장 억제, 즉 진균 세포의 성장을 억제할 수 있다는 것을 의미한다. "미생물 세포"라 함은 세균, 곰팡이, 또는 효모나 조류(algae) 등의 하등 진핵생물, 원생생물을 포함하는 최광의의 개념이다.
삭제
본 명세서에 개시된 항균, 항진균 펩티드는 미생물의 종류나 항균 대상에 상관없이 광범위한 적용이 가능하다. 전형적으로 세균, 진균, 효모 또는 조류에 의해 오염된 어떤 장소에도 유용하다. 전형적으로, 항균 대상은, 냉각수 시스템 등의 수성 시스템, 세탁장 헹굼물, 커팅오일 등의 오일 시스템, 윤활제, 유전 등이며, 미생물을 죽이거나 그들의 성장을 억제할 필요가 있는 장소이다. 또한, 본 명세서에 개시된 항균, 항진균 펩티드는 목재, 라텍스, 접착제, 아교, 종이, 판지, 텍스타일, 가죽, 플라스틱, 코킹, 및 사료의 보호와 같은, 항균, 항진균 조성물이 유용하다고 알려진 모든 용도에서 사용될 수 있다.
다른 용도는 음식, 음료수, 화장료, 예를 들어 로숀, 크림, 젤, 연고, 비누, 샴푸, 컨디셔너, 제한제, 방취제, 치약, 콘텍트렌즈 제품, 효소 조제물, 또는 음식 원료의 보존을 포함한다.
한편, 본 명세서에 개시된 펩티드는 소독제로서, 예를 들어 여드름, 눈이나 입의 감염, 피부 감염의 치료에서; 제한제 또는 방취제에서; 족욕용 염들에서; 콘텍트렌즈, 단단한 표면, 치아(구강관리), 상처, 멍 등의 세척과 소독에서 유용하다.
또한, 본 발명의 일측면은 항균 펩티드 또는 조성물의 의약으로서의 사용에 관한 것이다. 더 나아가, 본 명세서에 기재된 펩티드 또는 조성물은 또한 그람 양성 또는 그람 음성을 포함하는 세균, 곰팡이, 또는 효모나 조류(algae) 등의 하등 진핵생물, 원생생물과 같은 미생물을 제어하거나 그와 싸우기 위한 의약의 제조에 사용될 수 있다. 특히, 미생물 감염은, 이에 제한되지는 않지만 여드름이나 무좀과 같은 감염성 피부 질환; 이에 제한되지는 않지만 결핵 및 낭섬유증을 포함하는 폐질환; 이에 제한되지는 않지만 임질 및 클라미디아를 포함하는 성병에 관련될 수 있다.
본 발명의 일측면에 따른 조성물은 서열 번호 1의 서열을 갖는 펩티드, 서열 번호 1의 서열의 단편인 펩티드 또는 상기 펩티드 서열과 80% 이상의 서열 상동성을 갖는 펩티드를 0.1 ㎍/㎎ 내지 1 ㎎/㎎, 구체적으로 1 ㎍/㎎ 내지 0.5 ㎎/㎎, 더 구체적으로 10 ㎍/㎎ 내지 0.1 ㎎/㎎의 함량으로 포함할 수 있다. 상기 범위로 포함하는 경우 본 발명의 의도한 효과를 나타내기에 적절할 뿐만 아니라, 조성물의 안정성 및 안전성을 모두 만족할 수 있으며, 비용 대비 효과의 측면에서도 상기 범위로 포함하는 것이 적절할 수 있다.
본 발명의 일측면에 따른 조성물은 인간, 개, 닭, 돼지, 소, 양, 기니아피그 또는 원숭이를 포함하는 모든 동물에 적용될 수 있다.
본 발명의 일측면에 따른 약학 조성물은 경구, 직장, 경피, 정맥 내, 근육 내, 복강 내, 골수 내, 경막 내 또는 피하 등으로 투여될 수 있다.
경구 투여를 위한 제형은 정제, 환제, 연질 또는 경질 캅셀제, 과립제, 산제, 액제 또는 유탁제일 수 있으나, 이에 제한되는 것은 아니다. 비경구 투여를 위한 제형은 주사제, 점적제, 로션, 연고, 겔, 크림, 현탁제, 유제, 좌제, 패취 또는 분무제일 수 있으나, 이에 제한되는 것은 아니다.
본 발명의 일측면에 따른 약학 조성물은 필요에 따라 희석제, 부형제, 활택제, 결합제, 붕해제, 완충제, 분산제, 계면 활성제, 착색제, 향료 또는 감미제 등의 첨가제를 포함할 수 있다. 본 발명의 일측면에 따른 약학 조성물은 당업계의 통상적인 방법에 의해 제조될 수 있다.
본 발명의 일측면에 따른 약학 조성물의 유효 성분은 투여 받을 대상의 연령, 성별, 체중, 병리 상태 및 그 심각도, 투여 경로 또는 처방자의 판단에 따라 달라질 것이다. 이러한 인자에 기초한 적용량 결정은 당업자의 수준 내에 있으며, 이의 1일 투여 용량은 예를 들어 0.1 ㎍/kg/일 내지 1 g/kg/일, 구체적으로는 1 ㎍/kg/일 내지 10 mg/kg/일, 더 구체적으로는 10 ㎍/kg/일 내지 1 mg/kg/일, 보다 더 구체적으로는 50 ㎍/kg/일 내지 100 ㎍/kg/일이 될 수 있으나, 이에 제한되는 것은 아니다. 본 발명의 일측면에 따른 약학 조성물은 1일 1회 내지 3회 투여될 수 있으나, 이에 제한되는 것은 아니다.
본 발명의 일측면에 따른 화장료 조성물은 국소 적용에 적합한 모든 제형으로 제공될 수 있다. 예를 들면, 용액, 수상에 유상을 분산시켜 얻은 에멀젼, 유상에 수상을 분산시켜 얻은 에멀젼, 현탁액, 고체, 겔, 분말, 페이스트, 포말(foam) 또는 에어로졸의 제형으로 제공될 수 있다. 이러한 제형은 당해 분야의 통상적인 방법에 따라 제조될 수 있다.
본 발명의 일측면에 따른 화장료 조성물은 주 효과를 손상시키지 않는 범위 내에서, 바람직하게는 주 효과에 상승 효과를 줄 수 있는 다른 성분들을 포함할 수 있다. 또한 본 발명의 일측면에 따른 화장료 조성물은 보습제, 에몰리언트제, 계면 활성제, 자외선 흡수제, 방부제, 살균제, 산화 방지제, pH 조정제, 유기 또는 무기 안료, 향료, 냉감제 또는 제한(制汗)제를 더 포함할 수 있다. 상기 성분의 배합량은 본 발명의 목적 및 효과를 손상시키지 않는 범위 내에서 당업자가 용이하게 선정 가능하며, 그 배합량은 화장료 조성물 전체 중량을 기준으로 0.01 내지 5 중량%, 구체적으로 0.01 내지 3 중량%일 수 있다.
본 발명의 일측면에 따른 식품 조성물의 제형은 특별히 한정되지 않으나, 예를 들어, 정제, 과립제, 분말제, 액제, 고형 제제 등으로 제형화될 수 있다. 각 제형은 유효 성분 이외에 해당 분야에서 통상적으로 사용되는 성분들을 제형 또는 사용 목적에 따라 당업자가 어려움 없이 적의 선정하여 배합할 수 있으며, 다른 원료와 동시에 적용할 경우 상승 효과가 일어날 수 있다.
상기 유효 성분의 투여량 결정은 당업자의 수준 내에 있으며, 이의 1일 투여 용량은 예를 들어 구체적으로는 1 ㎍/kg/일 내지 10 mg/kg/일, 더 구체적으로는 10 ㎍/kg/일 내지 1 mg/kg/일, 보다 더 구체적으로는 50 ㎍/kg/일 내지 100 ㎍/kg/일이 될 수 있으나, 이에 제한되지 않으며, 투여하고자 하는 대상의 연령, 건강 상태, 합병증 등 다양한 요인에 따라 달라질 수 있다.
이하, 실험예를 들어 본 발명의 구성 및 효과를 보다 구체적으로 설명한다. 그러나 아래 실험예는 본 발명에 대한 이해를 돕기 위해 예시의 목적으로만 제공된 것일 뿐 본 발명의 범주 및 범위가 그에 의해 제한되는 것은 아니다.
[실험예] 펩티드의 항균력 평가
액체 배지 1 ml에 각각 300 ㎍/㎖, 600 ㎍/㎖ 및 1 ㎎/㎖ 농도의 pep 1을 가하였다. 이와 별도로 액체 배지에서 3 내지 5일 동안 전배양한 시험균(E. coli(Escherichia coli) E. floccosum(Epidermophyton floccosum) 및 T. mentagrophytes(Trichophyton mentagrophytes))의 배양액 1 내지 5 ㎕을 pep 1을 가한 액체 배지에 접종 하였다(세포 수: 103 내지 105/ml 시험관). 각 균주의 생육 적온에서 생육에 충분한 시간(1일 내지 3일)동안 배양하였다. 각 시험관의 O.D 값을 측정하여, 아래 표 3 내지 5, 및 도 1 내지 3에 나타내었다. 한편, 음성 대조군으로 각 균주만을 배양한 것을 음성 대조군으로 하였으며, 각 균주와 항생제를 함께 배양한 것을 양성 대조군으로 하였다(항생제로서, 박테리아는 테트라사이클린(Tetracycline)을 사용하고, 진균은 암포테리신 비(Amphotericin B)를 사용하였다).
| 균 | 균+항생제 | 300 ㎍/㎖ | 1 mg/ml | |
| E. coli | 0.427 | 0.072 | 0.362 | 0.081 |
| 균 | 균+항생제 | 300 ㎍/㎖ | 600 ㎍/㎖ | |
| E. floccosum | 0.346 | 0.066 | 0.053 | 0.045 |
| 균 | 균+항생제 | 300 ㎍/㎖ | 600 ㎍/㎖ | |
| T. mentagrophytes | 0.319 | 0.065 | 0.147 | 0.047 |
상기 결과에서 볼 수 있듯이, pep 1은 E. coli에 대해 1㎎/㎖ 농도에서 항균력을 나타냈고, E. floccosum 에 대해서는 300 ㎍/㎖ 및 600 ㎍/㎖ 농도에서 항균력을 나타내었다. T. mentargophytes에 대해서는 600 ㎍/㎖ 농도에서 항균력을 나타내었다.
SEQUENCE LISTING
<110> KAEL-GemVax Co., Ltd.
<120> Composition for antimicrobial or antivirus comprising telomerase
peptide
<130> 12P554
<160> 56
<170> PatentIn version 3.2
<210> 1
<211> 1132
<212> PRT
<213> Homo sapiens
<400> 1
Met Pro Arg Ala Pro Arg Cys Arg Ala Val Arg Ser Leu Leu Arg Ser
1 5 10 15
His Tyr Arg Glu Val Leu Pro Leu Ala Thr Phe Val Arg Arg Leu Gly
20 25 30
Pro Gln Gly Trp Arg Leu Val Gln Arg Gly Asp Pro Ala Ala Phe Arg
35 40 45
Ala Leu Val Ala Gln Cys Leu Val Cys Val Pro Trp Asp Ala Arg Pro
50 55 60
Pro Pro Ala Ala Pro Ser Phe Arg Gln Val Ser Cys Leu Lys Glu Leu
65 70 75 80
Val Ala Arg Val Leu Gln Arg Leu Cys Glu Arg Gly Ala Lys Asn Val
85 90 95
Leu Ala Phe Gly Phe Ala Leu Leu Asp Gly Ala Arg Gly Gly Pro Pro
100 105 110
Glu Ala Phe Thr Thr Ser Val Arg Ser Tyr Leu Pro Asn Thr Val Thr
115 120 125
Asp Ala Leu Arg Gly Ser Gly Ala Trp Gly Leu Leu Leu Arg Arg Val
130 135 140
Gly Asp Asp Val Leu Val His Leu Leu Ala Arg Cys Ala Leu Phe Val
145 150 155 160
Leu Val Ala Pro Ser Cys Ala Tyr Gln Val Cys Gly Pro Pro Leu Tyr
165 170 175
Gln Leu Gly Ala Ala Thr Gln Ala Arg Pro Pro Pro His Ala Ser Gly
180 185 190
Pro Arg Arg Arg Leu Gly Cys Glu Arg Ala Trp Asn His Ser Val Arg
195 200 205
Glu Ala Gly Val Pro Leu Gly Leu Pro Ala Pro Gly Ala Arg Arg Arg
210 215 220
Gly Gly Ser Ala Ser Arg Ser Leu Pro Leu Pro Lys Arg Pro Arg Arg
225 230 235 240
Gly Ala Ala Pro Glu Pro Glu Arg Thr Pro Val Gly Gln Gly Ser Trp
245 250 255
Ala His Pro Gly Arg Thr Arg Gly Pro Ser Asp Arg Gly Phe Cys Val
260 265 270
Val Ser Pro Ala Arg Pro Ala Glu Glu Ala Thr Ser Leu Glu Gly Ala
275 280 285
Leu Ser Gly Thr Arg His Ser His Pro Ser Val Gly Arg Gln His His
290 295 300
Ala Gly Pro Pro Ser Thr Ser Arg Pro Pro Arg Pro Trp Asp Thr Pro
305 310 315 320
Cys Pro Pro Val Tyr Ala Glu Thr Lys His Phe Leu Tyr Ser Ser Gly
325 330 335
Asp Lys Glu Gln Leu Arg Pro Ser Phe Leu Leu Ser Ser Leu Arg Pro
340 345 350
Ser Leu Thr Gly Ala Arg Arg Leu Val Glu Thr Ile Phe Leu Gly Ser
355 360 365
Arg Pro Trp Met Pro Gly Thr Pro Arg Arg Leu Pro Arg Leu Pro Gln
370 375 380
Arg Tyr Trp Gln Met Arg Pro Leu Phe Leu Glu Leu Leu Gly Asn His
385 390 395 400
Ala Gln Cys Pro Tyr Gly Val Leu Leu Lys Thr His Cys Pro Leu Arg
405 410 415
Ala Ala Val Thr Pro Ala Ala Gly Val Cys Ala Arg Glu Lys Pro Gln
420 425 430
Gly Ser Val Ala Ala Pro Glu Glu Glu Asp Thr Asp Pro Arg Arg Leu
435 440 445
Val Gln Leu Leu Arg Gln His Ser Ser Pro Trp Gln Val Tyr Gly Phe
450 455 460
Val Arg Ala Cys Leu Arg Arg Leu Val Pro Pro Gly Leu Trp Gly Ser
465 470 475 480
Arg His Asn Glu Arg Arg Phe Leu Arg Asn Thr Lys Lys Phe Ile Ser
485 490 495
Leu Gly Lys His Ala Lys Leu Ser Leu Gln Glu Leu Thr Trp Lys Met
500 505 510
Ser Val Arg Asp Cys Ala Trp Leu Arg Arg Ser Pro Gly Val Gly Cys
515 520 525
Val Pro Ala Ala Glu His Arg Leu Arg Glu Glu Ile Leu Ala Lys Phe
530 535 540
Leu His Trp Leu Met Ser Val Tyr Val Val Glu Leu Leu Arg Ser Phe
545 550 555 560
Phe Tyr Val Thr Glu Thr Thr Phe Gln Lys Asn Arg Leu Phe Phe Tyr
565 570 575
Arg Lys Ser Val Trp Ser Lys Leu Gln Ser Ile Gly Ile Arg Gln His
580 585 590
Leu Lys Arg Val Gln Leu Arg Glu Leu Ser Glu Ala Glu Val Arg Gln
595 600 605
His Arg Glu Ala Arg Pro Ala Leu Leu Thr Ser Arg Leu Arg Phe Ile
610 615 620
Pro Lys Pro Asp Gly Leu Arg Pro Ile Val Asn Met Asp Tyr Val Val
625 630 635 640
Gly Ala Arg Thr Phe Arg Arg Glu Lys Arg Ala Glu Arg Leu Thr Ser
645 650 655
Arg Val Lys Ala Leu Phe Ser Val Leu Asn Tyr Glu Arg Ala Arg Arg
660 665 670
Pro Gly Leu Leu Gly Ala Ser Val Leu Gly Leu Asp Asp Ile His Arg
675 680 685
Ala Trp Arg Thr Phe Val Leu Arg Val Arg Ala Gln Asp Pro Pro Pro
690 695 700
Glu Leu Tyr Phe Val Lys Val Asp Val Thr Gly Ala Tyr Asp Thr Ile
705 710 715 720
Pro Gln Asp Arg Leu Thr Glu Val Ile Ala Ser Ile Ile Lys Pro Gln
725 730 735
Asn Thr Tyr Cys Val Arg Arg Tyr Ala Val Val Gln Lys Ala Ala His
740 745 750
Gly His Val Arg Lys Ala Phe Lys Ser His Val Ser Thr Leu Thr Asp
755 760 765
Leu Gln Pro Tyr Met Arg Gln Phe Val Ala His Leu Gln Glu Thr Ser
770 775 780
Pro Leu Arg Asp Ala Val Val Ile Glu Gln Ser Ser Ser Leu Asn Glu
785 790 795 800
Ala Ser Ser Gly Leu Phe Asp Val Phe Leu Arg Phe Met Cys His His
805 810 815
Ala Val Arg Ile Arg Gly Lys Ser Tyr Val Gln Cys Gln Gly Ile Pro
820 825 830
Gln Gly Ser Ile Leu Ser Thr Leu Leu Cys Ser Leu Cys Tyr Gly Asp
835 840 845
Met Glu Asn Lys Leu Phe Ala Gly Ile Arg Arg Asp Gly Leu Leu Leu
850 855 860
Arg Leu Val Asp Asp Phe Leu Leu Val Thr Pro His Leu Thr His Ala
865 870 875 880
Lys Thr Phe Leu Arg Thr Leu Val Arg Gly Val Pro Glu Tyr Gly Cys
885 890 895
Val Val Asn Leu Arg Lys Thr Val Val Asn Phe Pro Val Glu Asp Glu
900 905 910
Ala Leu Gly Gly Thr Ala Phe Val Gln Met Pro Ala His Gly Leu Phe
915 920 925
Pro Trp Cys Gly Leu Leu Leu Asp Thr Arg Thr Leu Glu Val Gln Ser
930 935 940
Asp Tyr Ser Ser Tyr Ala Arg Thr Ser Ile Arg Ala Ser Leu Thr Phe
945 950 955 960
Asn Arg Gly Phe Lys Ala Gly Arg Asn Met Arg Arg Lys Leu Phe Gly
965 970 975
Val Leu Arg Leu Lys Cys His Ser Leu Phe Leu Asp Leu Gln Val Asn
980 985 990
Ser Leu Gln Thr Val Cys Thr Asn Ile Tyr Lys Ile Leu Leu Leu Gln
995 1000 1005
Ala Tyr Arg Phe His Ala Cys Val Leu Gln Leu Pro Phe His Gln
1010 1015 1020
Gln Val Trp Lys Asn Pro Thr Phe Phe Leu Arg Val Ile Ser Asp
1025 1030 1035
Thr Ala Ser Leu Cys Tyr Ser Ile Leu Lys Ala Lys Asn Ala Gly
1040 1045 1050
Met Ser Leu Gly Ala Lys Gly Ala Ala Gly Pro Leu Pro Ser Glu
1055 1060 1065
Ala Val Gln Trp Leu Cys His Gln Ala Phe Leu Leu Lys Leu Thr
1070 1075 1080
Arg His Arg Val Thr Tyr Val Pro Leu Leu Gly Ser Leu Arg Thr
1085 1090 1095
Ala Gln Thr Gln Leu Ser Arg Lys Leu Pro Gly Thr Thr Leu Thr
1100 1105 1110
Ala Leu Glu Ala Ala Ala Asn Pro Ala Leu Pro Ser Asp Phe Lys
1115 1120 1125
Thr Ile Leu Asp
1130
<210> 2
<211> 16
<212> PRT
<213> Homo sapiens
<400> 2
Glu Ala Arg Pro Ala Leu Leu Thr Ser Arg Leu Arg Phe Ile Pro Lys
1 5 10 15
<210> 3
<211> 30
<212> PRT
<213> Homo sapiens
<400> 3
Ala Leu Phe Ser Val Leu Asn Tyr Glu Arg Ala Arg Arg Pro Gly Leu
1 5 10 15
Leu Gly Ala Ser Val Leu Gly Leu Asp Asp Ile His Arg Ala
20 25 30
<210> 4
<211> 15
<212> PRT
<213> Homo sapiens
<400> 4
Ser Val Leu Asn Tyr Glu Arg Ala Arg Arg Pro Gly Leu Leu Gly
1 5 10 15
<210> 5
<211> 10
<212> PRT
<213> Homo sapiens
<400> 5
Gly Leu Leu Gly Ala Ser Val Leu Gly Leu
1 5 10
<210> 6
<211> 10
<212> PRT
<213> Homo sapiens
<400> 6
Ala Leu Leu Thr Ser Arg Leu Arg Phe Ile
1 5 10
<210> 7
<211> 9
<212> PRT
<213> Homo sapiens
<400> 7
Arg Pro Ala Leu Leu Thr Ser Arg Leu
1 5
<210> 8
<211> 9
<212> PRT
<213> Homo sapiens
<400> 8
Arg Leu Thr Ser Arg Val Lys Ala Leu
1 5
<210> 9
<211> 15
<212> PRT
<213> Homo sapiens
<400> 9
Arg Thr Phe Val Leu Arg Val Arg Ala Gln Asp Pro Pro Pro Glu
1 5 10 15
<210> 10
<211> 15
<212> PRT
<213> Homo sapiens
<400> 10
Arg Leu Thr Ser Arg Val Lys Ala Leu Phe Ser Val Leu Asn Tyr
1 5 10 15
<210> 11
<211> 15
<212> PRT
<213> Homo sapiens
<400> 11
Ala Glu Arg Leu Thr Ser Arg Val Lys Ala Leu Phe Ser Val Leu
1 5 10 15
<210> 12
<211> 9
<212> PRT
<213> Homo sapiens
<400> 12
Tyr Glu Arg Ala Arg Arg Pro Gly Leu
1 5
<210> 13
<211> 9
<212> PRT
<213> Homo sapiens
<400> 13
Leu Leu Gly Ala Ser Val Leu Gly Leu
1 5
<210> 14
<211> 10
<212> PRT
<213> Homo sapiens
<400> 14
Val Leu Gly Leu Asp Asp Ile His Arg Ala
1 5 10
<210> 15
<211> 10
<212> PRT
<213> Homo sapiens
<400> 15
Gly Ala Ser Val Leu Gly Leu Asp Asp Ile
1 5 10
<210> 16
<211> 10
<212> PRT
<213> Homo sapiens
<400> 16
Ala Leu Phe Ser Val Leu Asn Tyr Glu Arg
1 5 10
<210> 17
<211> 10
<212> PRT
<213> Homo sapiens
<400> 17
Ser Val Leu Asn Tyr Glu Arg Ala Arg Arg
1 5 10
<210> 18
<211> 10
<212> PRT
<213> Homo sapiens
<400> 18
Ser Val Leu Gly Leu Asp Asp Ile His Arg
1 5 10
<210> 19
<211> 10
<212> PRT
<213> Homo sapiens
<400> 19
Phe Ser Val Leu Asn Tyr Glu Arg Ala Arg
1 5 10
<210> 20
<211> 10
<212> PRT
<213> Homo sapiens
<400> 20
Asn Tyr Glu Arg Ala Arg Arg Pro Gly Leu
1 5 10
<210> 21
<211> 10
<212> PRT
<213> Homo sapiens
<400> 21
Tyr Glu Arg Ala Arg Arg Pro Gly Leu Leu
1 5 10
<210> 22
<211> 10
<212> PRT
<213> Homo sapiens
<400> 22
Arg Pro Gly Leu Leu Gly Ala Ser Val Leu
1 5 10
<210> 23
<211> 9
<212> PRT
<213> Homo sapiens
<400> 23
Glu Arg Ala Arg Arg Pro Gly Leu Leu
1 5
<210> 24
<211> 9
<212> PRT
<213> Homo sapiens
<400> 24
Val Leu Gly Leu Asp Asp Ile His Arg
1 5
<210> 25
<211> 9
<212> PRT
<213> Homo sapiens
<400> 25
Ser Val Leu Asn Tyr Glu Arg Ala Arg
1 5
<210> 26
<211> 9
<212> PRT
<213> Homo sapiens
<400> 26
Val Leu Asn Tyr Glu Arg Ala Arg Arg
1 5
<210> 27
<211> 9
<212> PRT
<213> Homo sapiens
<400> 27
Ala Arg Arg Pro Gly Leu Leu Gly Ala
1 5
<210> 28
<211> 9
<212> PRT
<213> Homo sapiens
<400> 28
Pro Gly Leu Leu Gly Ala Ser Val Leu
1 5
<210> 29
<211> 9
<212> PRT
<213> Homo sapiens
<400> 29
Arg Arg Pro Gly Leu Leu Gly Ala Ser
1 5
<210> 30
<211> 9
<212> PRT
<213> Homo sapiens
<400> 30
Ala Leu Phe Ser Val Leu Asn Tyr Glu
1 5
<210> 31
<211> 9
<212> PRT
<213> Homo sapiens
<400> 31
Gly Leu Leu Gly Ala Ser Val Leu Gly
1 5
<210> 32
<211> 9
<212> PRT
<213> Homo sapiens
<400> 32
Ser Val Leu Gly Leu Asp Asp Ile His
1 5
<210> 33
<211> 8
<212> PRT
<213> Homo sapiens
<400> 33
Glu Arg Ala Arg Arg Pro Gly Leu
1 5
<210> 34
<211> 8
<212> PRT
<213> Homo sapiens
<400> 34
Ala Arg Arg Pro Gly Leu Leu Gly
1 5
<210> 35
<211> 8
<212> PRT
<213> Homo sapiens
<400> 35
Gly Leu Leu Gly Ala Ser Val Leu
1 5
<210> 36
<211> 8
<212> PRT
<213> Homo sapiens
<400> 36
Arg Ala Arg Arg Pro Gly Leu Leu
1 5
<210> 37
<211> 8
<212> PRT
<213> Homo sapiens
<400> 37
Leu Gly Ala Ser Val Leu Gly Leu
1 5
<210> 38
<211> 15
<212> PRT
<213> Homo sapiens
<400> 38
Val Thr Glu Thr Thr Phe Gln Lys Asn Arg Leu Phe Phe Tyr Arg
1 5 10 15
<210> 39
<211> 15
<212> PRT
<213> Homo sapiens
<400> 39
Leu Phe Phe Tyr Arg Lys Ser Val Trp Ser Lys Leu Gln Ser Ile
1 5 10 15
<210> 40
<211> 15
<212> PRT
<213> Homo sapiens
<400> 40
Lys Leu Gln Ser Ile Gly Ile Arg Gln His Leu Lys Arg Val Gln
1 5 10 15
<210> 41
<211> 15
<212> PRT
<213> Homo sapiens
<400> 41
Glu Ala Glu Val Arg Gln His Arg Glu Ala Arg Pro Ala Leu Leu
1 5 10 15
<210> 42
<211> 15
<212> PRT
<213> Homo sapiens
<400> 42
Arg Pro Ala Leu Leu Thr Ser Arg Leu Arg Phe Ile Pro Lys Pro
1 5 10 15
<210> 43
<211> 15
<212> PRT
<213> Homo sapiens
<400> 43
Phe Ile Pro Lys Pro Asp Gly Leu Arg Pro Ile Val Asn Met Asp
1 5 10 15
<210> 44
<211> 15
<212> PRT
<213> Homo sapiens
<400> 44
Arg Thr Phe Arg Arg Glu Lys Arg Ala Glu Arg Leu Thr Ser Arg
1 5 10 15
<210> 45
<211> 15
<212> PRT
<213> Homo sapiens
<400> 45
Leu Asp Asp Ile His Arg Ala Trp Arg Thr Phe Val Leu Arg Val
1 5 10 15
<210> 46
<211> 15
<212> PRT
<213> Homo sapiens
<400> 46
Phe Val Leu Arg Val Arg Ala Gln Asp Pro Pro Pro Glu Leu Tyr
1 5 10 15
<210> 47
<211> 15
<212> PRT
<213> Homo sapiens
<400> 47
Pro Gln Asp Arg Leu Thr Glu Val Ile Ala Ser Ile Ile Lys Pro
1 5 10 15
<210> 48
<211> 15
<212> PRT
<213> Homo sapiens
<400> 48
Lys Ser Val Trp Ser Lys Leu Gln Ser Ile Gly Ile Arg Gln His
1 5 10 15
<210> 49
<211> 16
<212> PRT
<213> Homo sapiens
<400> 49
Leu Lys Arg Val Gln Leu Arg Glu Leu Ser Glu Ala Glu Val Arg Gln
1 5 10 15
<210> 50
<211> 9
<212> PRT
<213> Homo sapiens
<400> 50
Glu Ala Arg Pro Ala Leu Leu Thr Ser
1 5
<210> 51
<211> 9
<212> PRT
<213> Homo sapiens
<400> 51
Thr Ser Arg Leu Arg Phe Ile Pro Lys
1 5
<210> 52
<211> 9
<212> PRT
<213> Homo sapiens
<400> 52
Ala Arg Pro Ala Leu Leu Thr Ser Arg
1 5
<210> 53
<211> 9
<212> PRT
<213> Homo sapiens
<400> 53
Pro Ala Leu Leu Thr Ser Arg Leu Arg
1 5
<210> 54
<211> 9
<212> PRT
<213> Homo sapiens
<400> 54
Ala Leu Leu Thr Ser Arg Leu Arg Phe
1 5
<210> 55
<211> 9
<212> PRT
<213> Homo sapiens
<400> 55
Leu Leu Thr Ser Arg Leu Arg Phe Ile
1 5
<210> 56
<211> 9
<212> PRT
<213> Homo sapiens
<400> 56
Leu Thr Ser Arg Leu Arg Phe Ile Pro
1 5
Claims (6)
- 항균 또는 항진균용 조성물로서,
상기 조성물은 서열 번호 2의 서열로 이루어지는 펩티드를 유효 성분으로 포함하며,
상기 균 또는 진균은 대장균속(Escherichia), 에피더모파이톤속(Epidermophyton) 및 트리코파이톤속(Trichophyton)으로 이루어지는 군으로부터 선택된 하나 이상의 균 또는 진균을 포함하는, 항균 또는 항진균용 조성물. - 삭제
- 삭제
- 삭제
- 제 1 항에 있어서,
펩티드는 인간의 텔로머라제(telomerase)로부터 유래한 항균 또는 항진균용 조성물. - 제 1 항에 있어서,
조성물은 0.1 ㎍/㎎ 내지 1 ㎎/㎎ 함량의 펩티드를 포함하는 항균 또는 항진균용 조성물.
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| CN108841802B (zh) | 2012-05-11 | 2023-06-09 | 珍白斯凯尔有限公司 | 抗炎性肽及包含其的组合物 |
| JP6272853B2 (ja) | 2012-07-11 | 2018-01-31 | ジェムバックス アンド カエル カンパニー，リミティド | 細胞透過性ペプチド、それを含んだコンジュゲート、及びそれを含んだ組成物 |
| RU2725744C2 (ru) | 2013-06-07 | 2020-07-03 | Джемвакс Энд Каэл Ко., Лтд. | Биологические маркеры, которые могут быть использованы в иммунотерапии рака |
| WO2014204281A1 (ko) | 2013-06-21 | 2014-12-24 | 주식회사 카엘젬백스 | 호르몬 분비 조절제, 이를 포함하는 조성물, 및 이를 사용한 호르몬 분비 조절 방법 |
| EP3072519B1 (en) | 2013-11-22 | 2020-08-19 | Gemvax & Kael Co., Ltd. | Peptide having angiogenesis inhibitory activity and composition containing same |
| EP3085380B1 (en) | 2013-12-17 | 2020-06-17 | Gemvax & Kael Co., Ltd. | Composition for treating prostate cancer |
| EP3138399B1 (en) | 2014-04-30 | 2023-09-06 | Gemvax & Kael Co., Ltd. | Composition for organ, tissue, or cell transplantation, kit, and transplantation method |
| KR102413243B1 (ko) | 2014-12-23 | 2022-06-27 | 주식회사 젬백스앤카엘 | 안질환 치료 펩티드 및 이를 포함하는 안질환 치료용 조성물 |
| US10835582B2 (en) | 2015-02-27 | 2020-11-17 | Gemvax & Kael Co. Ltd. | Peptide for preventing hearing loss, and composition comprising same |
| WO2017003267A1 (ko) * | 2015-07-02 | 2017-01-05 | 주식회사 젬백스앤카엘 | 항바이러스 활성 효능을 가지는 펩티드 및 이를 포함하는 조성물 |
| JP7114481B2 (ja) | 2016-04-07 | 2022-08-08 | ジェムバックス アンド カエル カンパニー，リミティド | テロメラーゼ活性の増加及びテロメアの延長の効能を有するペプチド、及びこれを含む組成物 |
| KR102445492B1 (ko) * | 2021-12-24 | 2022-09-21 | 엔케이젠 주식회사 | 신규한 펩타이드를 포함하는 자연살해세포 대량증식용 조성물 및 이를 이용한 자연살해세포 대량증식방법 |
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