KR102000818B1 - Cortex skin lipid component separation utilizing the principle and the hydrophobic composition and a manufacturing method of a cleaning material of Aerogel. - Google Patents

Abstract

The present invention relates to a method for removing lipid components from sebum formed on skin epithelium and female facial cleansing using silica Aerogel which crystallizes silicon dioxide (SiO2) particles in nano units, and a method for removing melanin A composition having the effect of inhibiting and improving the deposition of a pigment is provided.

Description

TECHNICAL FIELD The present invention relates to a method for separating and cleaning a cortical lipid component using a hydrophobic principle of Aerogel and a method for manufacturing the composition having a cleaning effect.

The present invention relates to a composition having a cortical lipid component separation and cleaning effect utilizing the hydrophobic principle of Aerogel. More specifically, it is used to prevent and improve inflammation-induced diseases caused by erosion of skin of acne, sebum diseases, boring dermatitis and cosmetic composition caused by lipophilic skin of male and female using Aerogel as a nontoxic and harmless raw material. The present invention relates to a composition for separating and cleaning lipids in the skin.

Common types of cleansing products for use on the face and scalp as well as for cleaning and cleansing the entire body include solid soaps, liquid lotions, gel-like creams and foams, oils and the like. Sodium lauryl Sulfate (SLS) is used as a surfactant for cleansing solvents, which is used in cosmetics companies and some DYI household products since it has good cleaning effect and low cost. However, when overuse or persistent use of SLS, the stimulus of the skin is strong and it damages the cortex, promoting the skin aging, or drying it, which may cause dry dermatitis.

Therefore, it was tried to minimize skin irritation by using "Sodium Laureth Sulfate" (SLES). However, in case of inhaling or inserting SLES through animal experiments, it has been proved that it is a substance that can cause cancer.

Clinical Toxicology, an authoritative international journal published by the Toxicological Society of America in January 2012, reports on the membrane integrity and metabolism of surfactants in cardiac cells, lung cells, Metabolic activity, mitochondrial activity, and total protein synthesis rate were investigated. Among the surfactants, SLES, LE-2S and LE-2 showed moderate toxicity. Severe toxicity was observed in TN-20, LN-10 and PE-61.

Such synthetic surfactants are easily absorbed through the skin, and it has been found that when the synthetic surfactant is accumulated in the human body due to repeated absorption, there is a possibility of causing genetic modification in the body and further leading to cancer or a chronic disease . In addition, since synthetic surfactants such as SLS and SLES directly contact the skin, they can cause skin irritation and various skin diseases, and their harmfulness is very serious.

On the other hand, Aerogel is a silica structure having a three-dimensional mesh structure, and more than 90% is a porous material composed of pores having nano size. Due to its low density and high porous structure, it has attracted attention as an excellent performance catalyst, adsorbent, absorbing material, and heat insulating material. Such silica aerogels have hydrophilicity, and when they are exposed to the external environment, the pores gradually collapse due to moisture, resulting in deterioration of physical properties. In order to eliminate this phenomenon, the Aerogel surface is modified to be hydrophobic so that it is not affected by moisture and moisture even when exposed to the external environment for a long time.

Therefore, research and development using Aerogel, which is capable of removing and cleaning fats and make-up materials accumulated on the skin without using a surfactant, as well as inhibiting and improving the deposition of melanin pigment due to hormone and protein action There is a need.

In the Korean Patent Publication No. 10-2015-0023829, at least one oil which is preferably non-volatile, at least hydrophobic silica airgel particles, preferably a number of not more than 10000 g / mol, one or more hydrocarbon resins having an average molecular weight Discloses a cosmetic composition for skin and / or lips makeup and / or care comprising said composition in a physiologically acceptable medium comprising less than 5% by weight of water based on the total weight of the composition and preferably anhydrous, have. In the domestic patent publication No. 10-2015-0023830, at least one nonvolatile oil, at least hydrophobic silica airgel particles, at least one wax having a melting point of at least 60 캜, said composition comprising less than 5% by weight of water, Discloses a liquid cosmetic composition for skin and / or lips make-up and / or care comprising a physiologically acceptable medium which comprises, preferably, anhydrous. In the domestic patent publication No. 10-2015-0023842, at least one, preferably non-volatile oil, at least hydrophobic silica airgel particles, at least one semi-crystalline polymer, said composition comprising less than 5% by weight of water Preferably at least one lipid phase comprising anhydrous, in a physiologically acceptable medium, preferably a liquid cosmetic composition for skin and / or lip make-up and / or care. In domestic patent publication No. 10-2015-0023844 there is disclosed a process for the production of at least one hydrocarbon obtained from at least one oil, at least hydrophobic silica airgel particles, preferably one or more styrene monomers, preferably non-volatile, in a physiologically acceptable medium Based block copolymer, said composition comprising less than 5% by weight of water based on the total weight of the composition, preferably at least one lipid phase comprising anhydrous, preferably a makeup for the skin and / or lips / RTI > and / or < RTI ID = 0.0 > care. ≪ / RTI > However, the above-mentioned prior arts differ from the composition and effect of the invention in that the composition having the effect of separating and cleaning the cortical lipid component utilizing the hydrophobic principle of Aerogel for the purpose of the present invention.

It is an object of the present invention to utilize safe aerogels that are safe and non-toxic, which can escape the danger of conventional surfactants, as a composition of a detergent which can exhibit lipid separation and cleaning effect in the skin while maintaining skin moisture.

For the purpose of the present invention described above, the present invention relates to a composition for eliminating sebum formed on the skin layer of the skin and the remaining cosmetic ingredients from the non-toxic and harmless safe aerogels and for suppressing deposition of the melanin pigment of the dermal layer and inhibition of the deposited pigment . Aerogel is characterized in that the particle size of silicon dioxide (SiO 2) is 1 to 20 μm (Pore Diameter: 1000 to 20000 nm) and the surface is hydrophobic treated porosity of 90 to 99%. Aerogel is a sol- , Hydrophobic process, and drying process to produce hydrophobic Aerogel.

In addition, the composition having the effect of separating and cleaning the cortical lipid component utilizing the hydrophobicity principle of Aerogel adds an oil component in order to immobilize the hydrophobic aerogels on the formulation, and the oil component accounts for 25-30 wt% , The content of palmitic acid is 11 to 14 wt%, the content of myristic acid is 1 wt%, the content of oleic acid is 44 to 47 wt%, the content of palmitoleic acid is 25 to 28 wt%, the content of stearic acid is 1 to 14 wt% 3% by weight of linoleic acid and 6-10% by weight of linoleic acid, respectively. 20 to 30% by weight of a mixture of a crude extract and a non-extract, which was prepared by grinding to remove the water extract and the fibrinous extract extracted from a 98% alcohol solution at room temperature for 3 days or more, The present invention provides a composition having a skin cortical lipid component separation and cleaning effect utilizing the hydrophobic principle of Aerogel, which comprises 10 to 20% by weight of carboxymethylcellulose, 2 to 5% by weight of carboxymethylcellulose, and 2 to 5% do.

The aerogels and natural skin bleaching materials according to the present invention can be applied to raw materials such as soaps, natural detergents and cleansing foams, creams, ultraviolet screening agents and mask packs to remove skin fats and cosmetic impurities, It is safe from adverse effects, and it is possible to secure safety against lipid-induced dermatitis and skin cancer, and can inhibit melanin pigment deposition such as spots and freckles due to skin aging and pigmentation.

1 is a photograph showing the result of washing with soap.
2 is a photograph showing the result of cleaning using an Aerogel cleaning cream.
3 shows the result of cell culture microscopic examination of the melanin inhibition experiment for dermal layer.

The present invention is characterized by using an aerogel as an extremely safe and effective skin and epidermal lipid adsorbent material that replaces the synthetic surfactant used in conventional cleaning and cleansing. Silica aerogels that crystallize silicon dioxide (SiO2) particles in nano units are used to remove sebum from sebaceous glands forming on the epithelial cells of skin and women's cosmetic cleansing. To provide a cosmetic composition and a method for producing the same.

Fixing agent for commercialization consists of Saturated fats and Unsaturated fats contained in the raw materials extracted from natural materials such as rady oil and canola oil, and also contains glycerine as an emulsifying agent. The present invention provides a whitening effect by replacing existing chemical bleaching materials with natural ingredients by mixing the raw persimmon and radish ingredients for the purpose of removing the remaining cosmetic ingredients and depositing the melanin pigment of the dermis layer and suppressing the deposited pigment. Hereinafter, specific examples of the composition having the effect of separating and cleaning the cortical lipid component utilizing the hydrophobic principle of Aerogel of the present invention will be described in detail.

Ⅰ. A method for preparing a composition having the effect of separating and cleaning the cortical lipid component of a human body using the hydrophobic principle of Aerogel.

In the present invention, the hydrophobic Aerogel used as a core raw material for absorbing and removing cosmetic ingredients and sebum of the skin refers to a particle of silicon dioxide (SiO2) crystallized in the form of nanometers, and the particle size of silicon dioxide (SiO2) Porosity 90-99% Aerogel whose surface has been subjected to a hydrophobic treatment at 20 탆 (Pore Diameter: 1000-20000 nm) was mixed with 1 to 30% by weight based on the total weight of the cleansing cream. The above-mentioned method of producing Aerogel having hydrophobicity was manufactured using typical synthetic techniques. Specifically, it is as follows.

The first step is a sol-gel process in which a basic catalyst is added to a silica sol prepared by hydrolyzing a raw material of water glass with an acid catalyst to produce a hydrophilic wet gel through a condensation reaction. As the acid catalyst, hydrofluoric acid, hydrochloric acid, sulfuric acid, nitric acid and the like are used. As the base catalyst, sodium hydroxide, ammonia water, pyridine, hydrazine, piperidine and the like are used.

The second step is a hydrophobic process. In order to modify the surface of a hydrophilic wet gel to hydrophobic property, a wet gel is put in an organic solvent to replace the water inside the gel with an organic solvent, and then a hydrophobic agent is added to the hydrophilic gel surface. Lt; / RTI > As the organic solvent, acetone, isopropanol, ethanol, methanol, n-hexane, n-heptane, butanol, xylene and the like are used and the hydrophobizing agent is chlorotrimethylsilane, hexamethyldisilazane, methyltrimethoxysilane, trimethylethoxysilane, Triethoxysilane, phenyltriethoxysilane, and other halogen, alkyl, alkoxy, and aromatic silane.

In the third step, as a drying step, the modified hydrophobic gel is washed to remove the unreacted material, and the hydrophobic airgel is produced through supercritical drying or atmospheric pressure drying. The washing solution may be selected from the organic solvents used for solvent substitution, and the drying may be selected from high temperature and high pressure drying using supercritical equipment, CO2 low temperature and high pressure drying using supercritical equipment, and atmospheric drying drying in air. Hydrophobic Aerogels were prepared through several steps.

An oil component was added to immobilize the above hydrophobic Aerogel on the formulation. When the total amount of the composition is 100% by weight, the amount of palmitic acid is 25-28% by weight, the content of stearic acid is 12-14% by weight, the content of myristic acid is 1 44 to 47% by weight of oleic acid, 3 to 5% by weight of palmitoleic acid, 6 to 10% by weight of linoleic acid and 3 to 5% by weight of oleic acid.

In addition, Rehmannia glutinosa, which contains 11 amino acids such as beta-sitosterol, campesterol, stigmasterol and geotoxin Rehmannin and mannitol, Liboschitz ex Steudel) and R-NCS structure. It contains a sulfur-containing physiologically active substance, isothiocyanate (R), and it is mixed with Raphanus sativus extract which has anticancer, antibacterial and insecticidal action Respectively. The composition is characterized by a component that inhibits the production of melanin pigment, which is increasing with aging through the complex reaction of Sulfur with sulfur extract.

The mixture ratio of Sukjwanghwang extract and non-extract was 50:50 by weight. The Sukhwangwang extract was extracted from 98% of the extracts at room temperature for more than 3 days, the extract was ground to remove fibrin, After purification, the two extracts were mixed.

Finally, 20 ~ 30 wt.% Of a mixture of oil and melanin pigment inhibitor, Sukjunghwang extract and no extract was added to a mixture of Aerogel and an oil component. In order to emulsify the mixture of the Sukjibu Extract and the Radish Extract, about 10 to 20% by weight of glycerin was mixed together. Also, carboxymethyl cellulose (CMC) and wax can be contained in an amount of 2 to 5% by weight in order to improve the concentration, viscosity and feel.

Ⅱ. Examples of compositions having the effect of separating and cleansing the cortical lipid component of the body using the hydrophobic principle of Aerogel

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[Example 1: Skin surface layer sebum and cosmetic impurity removal test of Aerogel cleansing cream]

In order to confirm the cleaning effect of the soap and the Aerogel cleansing cream of the present invention, a line was drawn with the oil-based magic in the hand to confirm the degree of removal of the ink (FIGS. 1 and 2). FIG. 1 shows that a magic line is left even after cleaning as a result of drawing the magic on the back of the hand and cleaning it with soap. FIG. 2 shows that the magic line was cleanly removed after cleaning as a result of applying the magic on the back of the hand and cleaning it with the airgel cleansing cream.

[Example 2: melanin inhibition test for dermal layer]

HM3KO cells (KCLB No. 80003), human melanoma cells, were cultured in Dulbecco's modified Eagle's Medium, 90%, heat inactivated fetal bovine serum (FBS), 10%, and 37 ° C and 5% CO2. The cultured cells were plated on two flasks, and the cells were allowed to adhere to the wall by proliferation for 12 hours so that the cell number was about 3 × 10 ⁵ .

One of the flasks was added to the adherent cells as a control group, and the other medium was added to the treated medium. The other medium was the medium, The cells were cultured until all of them were cold. The control and treated groups were washed with PBS, and incubated with 1 N sodium hydroxide. The absorbance was measured at 405 nm (UV-Vis Spectrophotometer, Oceanoptics, USA).

When the absorbance of the control group was 0.78 ± 0.04 AU at 100%, the absorbance of the treated group was 0.192 ± 0.03 AU, which was about 24%, indicating that the melanin formation inhibitory effect was about 75% or more. Cell culture microscopy also showed differences in cell saturation between control and treated groups.

The composition having the effect of separating and cleaning the skin cortical lipid component utilizing the hydrophobic principle of Aerogel according to the present invention and the manufacturing method thereof can provide a highly safe and effective skin and a skin care product which replace the synthetic surfactant used in the conventional cleaning and cleansing. Since Aerogel is provided as an epidermal lipid adsorbent, it can be used safely compared to conventional skin cleansing products. Therefore, it is expected that it will be a base for development of products such as cosmetics, soap, and natural detergent in addition to cleansing products in the future. have.

Claims (3)

15% by weight of Aerogel having a porosity of 90 to 99%, hydrophobic surface treated with silicon dioxide (SiO2) having a particle size of 1 to 20 탆 (Pore Diameter: 1000 to 20000 nm), 30% And 30% by weight of a mixture of the extract without extract,
3% by weight of carboxymethylcellulose, 2% by weight of wax, and the balance of 20% by weight of glycerin were mixed in the composition;
In the oil component, 25-28 wt% of palmitic acid, 11-14 wt% of stearic acid, 1 wt% of myristic acid, 44-47 wt% of oleic acid, 3 wt% of palmitoleic acid, 7-10 wt% of linoleic acid, % By weight,
The mixture of the Sukjunghwang extract and the non-extract was prepared by mixing the Sukhwangju extract and the non-extract at a ratio of 1: 1 on the weight ratio of 98% A composition having a skin cortical lipid component separation or cleaning effect delete delete

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