KR101951203B1 - A composition for preventing or treating respiratory cancers comprising herbal ingredients - Google Patents

Abstract

The present invention relates to a pharmaceutical composition for the prevention or treatment of respiratory cancer comprising a herbal composition, and more particularly to a pharmaceutical composition for preventing or treating respiratory cancer, which comprises as an active ingredient a herbal composition, a herbarium ginseng root, The present invention relates to a composition for preventing or treating respiratory cancer.

Description

TECHNICAL FIELD [0001] The present invention relates to a composition for preventing or treating respiratory cancer,

The present invention relates to a pharmaceutical composition for the prevention or treatment of respiratory cancer comprising a herbal composition, and more particularly to a pharmaceutical composition for preventing or treating respiratory cancer, which comprises as an active ingredient a herbal composition, a herbarium ginseng root, The present invention relates to a composition for preventing or treating respiratory cancer.

Lung cancer is the third most common cancer in Korea. Recently, mortality from cancer and liver cancer has been reduced, while mortality from lung cancer has increased sharply. The 5-year survival rate of lung cancer is only 13%, which is known to be worse than other cancers of the pancreas, liver, and esophagus except cancer.

Lung cancer is common in people aged 40 to 70, and rarely occurs before age 40. The incidence of males and females has increased since the 1980s compared to 7: 1 in the 1960s. This is attributed to the increase in female smoking rates.

The major risk factors for lung cancer are occupational exposure to smoking and other carcinogenic substances, with more than 90% of cancers occurring in trachea and bronchus being reported to result from smoking. Lung cancer is classified into non-small cell carcinoma and small cell carcinoma according to microscopic cell types of cancer cells. Non-small cell lung cancer accounts for about 80% of total lung cancer and squamous cell carcinoma squamous cell carcinoma, adenocarcinoma, and large-cell carcinoma.

Small cell lung cancer accounts for about 20% of all lung cancers, and it usually develops primarily in the airways (trachea or bronchus). Carcinomas are usually produced along the surface or line of an organ, most (4/5) in the middle of the lung, and the rest (1/5) in the periphery. Overall, malignancy is so rapid that it tends to grow at a rapid rate and to migrate away early through the lymphatic system or blood circulation. However, in the case of non-small cell lung cancer, even in patients who were able to undergo complete surgical resection, many patients recurred after surgery, Long-term survival is possible in only 70% of patients, 30-50% in stage 2, and 10-30% in stage 3. Overall, the 5-year survival rate is only 30% and the 10-year survival rate is only 15%. Although there have been a number of attempts to improve the outcome of such poor treatment, some have been proven effective in some cases, such as the combination of chemotherapy and radiotherapy before and after surgery, but these side effects are still present and the treatment rate is still unsatisfactory .

Many researches have been conducted to find natural products exhibiting anticancer effects against lung cancer with few toxicity and side effects. In particular, studies on the development of anticancer drugs and anticancer drugs using relatively safe human medicines have been actively conducted.

It is an object of the present invention to provide a composition for preventing or treating respiratory cancer which can achieve the effect of enhancing the efficacy of a drug and lowering side effects.

Another object of the present invention is to provide a health functional food for preventing or ameliorating respiratory cancer comprising the herbal medicine ingredient as an active ingredient.

In order to solve the above problems,

The present invention provides a herbal composition for preventing or treating respiratory cancer, which contains a herbal medicine ingredient of moss and persimmon as an active ingredient.

In the present invention, the composition may further comprise a ginseng root or ginseng, Cordyceps, and Jang Saeng Doraji.

In the present invention, the composition may contain 1 to 10% by weight of wheat straw and 1 to 10% by weight of rice straw, based on the weight of the composition.

The composition according to the present invention may be used in a variety of forms such as a tablet, a chewing gum, a citron, a dozen, a clam, a rhubarb, a licorice, a cinnabar, a dermis, Ginseng, ginseng, control, rhizome, rhubarb, peppermint, ginseng, ginseng, ginseng, guisha, killer, virginia, mulberry, , One or more herbal medicine ingredients selected from the group consisting of ginkgo leaf, hwangjeong, prawn, keel, coriander, persimmon, sorghum, black potato, white porcelain, malt,

In the present invention, the composition may be for a natural product herbal medicine prescription.

In the present invention, the composition may be for producing an anticancer resonant end.

Also, the composition may be administered by oral absorption, transdermal absorption, mucosal absorption, inhalation, dysphagia, salvage, or injection.

The present invention also provides a health functional food for preventing or ameliorating respiratory cancer comprising the herbal medicine ingredient as an active ingredient.

The present invention provides a herbal composition for prevention or treatment of respiratory cancer and an herbal composition containing the herbal medicine ingredient as an active ingredient, the herbal composition comprising sesame and persimmon extract as active ingredients, and a health functional food for preventing or ameliorating respiratory cancer. The composition and the health functional food according to the present invention contain a herbal medicine ingredient of moss and radish, and thus have excellent anticancer effect against respiratory cancer.

FIG. 1 is a graph showing the cytotoxicity test results on lung cancer cells of wort extract. FIG.
2 is a graph showing the results of cytotoxicity tests on lung cancer cells of the extract of Rana cv.
FIG. 3 is a graph showing cytotoxicity test results of lung cancer cells of mixed crude drug extract. FIG.

BRIEF DESCRIPTION OF THE DRAWINGS The present invention is capable of various modifications and various embodiments, and specific embodiments are illustrated in the drawings and described in detail in the description. It is to be understood, however, that the invention is not to be limited to the specific embodiments, but includes all modifications, equivalents, and alternatives falling within the spirit and scope of the invention. DETAILED DESCRIPTION OF THE PREFERRED EMBODIMENTS Hereinafter, the present invention will be described in detail with reference to the accompanying drawings.

As used herein, "subject of application" may mean a disease or a disease itself, and may also mean an individual or patient with a disease or condition, preferably a patient with lung cancer or lung cancer .

In addition, the term "applied" may mean injecting, injecting, or absorbing a drug into the application target, and may mean that the drug directly or indirectly reaches the application target to exhibit the drug effect.

Hereinafter, the present invention will be described in more detail.

The present invention provides a herbal composition for preventing or treating respiratory cancer, which contains a herbal medicine ingredient of moss and persimmon as an active ingredient.

The above-mentioned incense ( Inula helenium ) is also called honey aroma because the aroma is like honey. It also has five roots in one plant, five branches in one stem, five leaves in one branch, five nodes in each leaf, and it is also called ogyang (五 香). It is said to spread. This medicine has a peculiar smell, and the taste is spicy and the quality is warm.

It is used for abdominal pain, diarrhea, vomiting and diarrhea caused by abdomen. It is effective for chronic inflammation of stomach, stomach cramps, antimicrobial action, and is used for dysentery and testis inflammation. And blood pressure lowering action, antibacterial action, etc. have been reported.

In addition, the dansans is also called red ginseng, and it treats windmill disease (wind disease) and eliminates the feeling of helplessness, so it is called the name of ぬ 馬 草.

Dansam helps blood circulation, removes eosinophils, alleviates pain in the extremities, treats menstrual irregularities, menstrual cramps, postpartum abdominal pain, abdominal fullness, and bruises. It treats mental confusion, bullshit, fury, insomnia, skin rash, palpitation, etc. due to high fever. Pharmacological actions have been reported for coronary artery dilatation, cholesterol depression, hypotension, liver function activation, sedative anti-inflammatory, anti-cancer, and antimicrobial effects.

The composition may further comprise ginseng or ginseng, Cordyceps, and Jang Saeng Doraji.

The above-mentioned ginseng is also called as ginseng, camphor, camphor, ginseng or elder, and the ginseng seed is sprayed on the mountains and grown in a wild state.

Ginseng (Panax ginseng) is used as a medicinal lotion, ginseng, gangjeong and soothing medicine in a herbal medicine. It is prescribing to the depression of the stomach, deterioration of metabolism, stomach weakness, indigestion and anorexia. It has various physiological activities such as inhibition of aging, prevention of camellia hardening, improvement of hyperlipidemia, improvement of liver function, antioxidant effect, anti-stress effect, immunity enhancement, improvement of brain function and anticancer effect. Normalization.

In particular, the ginsenoside component of ginseng has been shown to have anti-cancer effects as well as ginsenoside Rg1 / Okamura N et al. Biol. Pharm. Bull. 17 (2), 270 (1), 1 (1993)), stimulation of hormone secretion (Ginsenoside Rg1 / Yoshimatsu H et al. Physiology and Behavior, 53 (Ginsenoside Rd, Re / Hiai S et al., Chem Pharm Bull 31, 168 (1983)), ginsenoside Rb1 / Zhang JT et al. Acta Pharmaceutica Sinica 23 (1), 12 )) And has been known to have various pharmacological effects.

In addition, the ginseng (玄 蔘) is known as the middle stage, the modern (玄 臺), the 鬼 藏 (馬 藏) and the horse (馬 馬), the plant grows in the mountain, , Boils and lymphatic glands, and it is known that ginsenosides contain a large amount of Rg3 and Rh2, which have anticancer effects.

In addition, Cordyceps militaris was inserted in the winter to live in the body of insects, absorb nutrients to kill the insects, and then to make mushrooms in the bodies of dead insects in the summer. Cordyceps, along with ginseng and antler, have long been known as one of the three most popular Chinese pills.

Cordyceps contains about 7% of acetic acid. It helps to help the lungs, lubes the lungs, stops the bleeding, removes the sputum, and is known to have a good therapeutic effect on anemia and old age weakness. It has been used as a leap for Gangjeong. The main record of the Chinese record is that it is used to protect the lungs, to help the kidneys, to remove the sputum and to cure the tuberculous cough. The natural medicines are sweet and sweet, help the kidney function, strengthen the lungs, strengthen the tongue, Anemia, etc. Antimicrobial activity with inhibitory action on Mycobacterium tuberculosis, Streptococcus pneumoniae, Low hemorrhagic septicemia bacillus, Gypsophila aphos, Bacillus anthracis, and non-bacillus; Central nervous system effects such as gangjeong tang, effective sleep induction, suppression of central nervous excitement, anticonvulsive action, body temperature depression; Respiratory system effects such as cold, chronic cough, asthma, effects on tuberculosis, bronchodilation, removal of sputum, respiratory stabilization; Cardiovascular system effects such as pulmonary dysfunction treatment, heart rhythm gang action, hypotensive action, cholesterol lowering action, oxygen deprivation durability, anti-platelet aggregation action; Natural healing power, immunity enhancement such as inflammation suppression; Antitumor activity; Antifoaming action; Chronic antipyretic action; Drug addiction detoxification; It is known to be effective in treating jaundice.

Platycodon grandiflorum refers to platycodon of more than 20 years old. Despite various pharmacological actions of platycodon, it has been difficult to cultivate for a long time. However, the technology to cultivate long platycodon, Has been developed and mass production has become possible. Such Jang Saeng Doraji is superior in pharmacological action and physiological activity effect to general Doraji of 2 ~ 4 years old muscle.

Platycodon grandiflorum A. DC is a plant of the Campanulaceae, about 10 to 15 cm in diameter, 1 to 3 cm in diameter, with irregular stems on the upper part, gray to milky white, with deep vertical wrinkles, There are twigs and wrinkles. The vagina is hard, non-fibrous, easy to break, slightly odorless, and tastes good (Jang Chang Soo et al., Hyundai Genetics, Seoul, Changsha, 460-461, 1993). The main pharmacological component of the bellflower is tritiated with saponins (platycodin A, C, D, D2 and D3), which account for about 3% of the roots. (Anti-inflammatory effect against acute chronic inflammation, anti-ulcer and gastric secretion suppressing action, anti-cholinergic action to lower blood pressure by expanding blood vessels, hypoglycemic action, and improvement of cholesterol metabolism) It is.

The composition may contain a mixture of wheat germ and spinach at a weight ratio of 1: 0.5 to 1.5. Based on the total weight of the composition, 1 to 10% by weight of corn, 1 to 10% by weight of corn germ. More preferably from 3 to 8% by weight of cornflower and from 3 to 8% by weight of cornflower,

In addition, the composition may further comprise ginseng root ginseng, Chinese caterpillar fungus and Jang Saeng Doraji, and the weight ratio thereof may be in the order of 1: 0.5 to 1.5: 0.5 to 1.5. Based on the weight of the composition, 20 to 40% by weight of goat or ginseng, 20 to 40% by weight of cordyceps, and 20 to 40% by weight of Jang Saeng Doraji. More preferably 25 to 35% by weight of the ginseng root ginseng or the ginseng root, Cordyceps sinensis, and Jang Saeng Doraji.

In addition, the composition may be used in a variety of compositions including, but not limited to, gibbons, rhododendrons, rhododendrons, rhododendrons, rhododendrons, rhubarb, licorice, , Ginger, ginseng, control, rhizome, rhubarb, peppermint, mackerel, ginseng, goose, gojae, lemonade, And may further comprise at least one herbal medicine ingredient selected from the group consisting of Hwangjeong, prawn, keel, coriander, oyster, sorghum, black potato, white porcelain, malt,

In addition, the composition may be one for a natural product herbal medicine prescription, and may be for producing an anticancer cavity.

In addition, the composition may be administered by oral absorption, transdermal absorption, mucosal absorption, inhalation, stool, bupivacaine or injection.

The present invention also provides a health functional food for preventing or ameliorating respiratory cancer comprising the herbal medicine ingredient as an active ingredient

It is to be understood that both the foregoing general description and the following detailed description are exemplary and explanatory and are intended to be illustrative of the present invention and the scope of the invention as defined by the appended claims. It will be obvious to those skilled in the art that these modifications and variations are included in the scope of the appended claims.

Production Example 1: Preparation of Wort and Radix extract

Herbal medicine extracts were prepared by the following methods, which were herbal ingredients for preventing or treating respiratory cancer.

After washing thoroughly in flowing water, the mixture was mixed with distilled water for about 2 hours, and the residue was separated. The solution was transferred to a distillation extractor in a sterile room and transferred to obtain 1000 ml of extracts. The obtained extract was filtered twice with 0.45 mu m and 0.2 mu m filter paper to prepare an extract.

Danshams were also prepared in the same way as those of the field.

Production Example 2: Preparation of mixed crude drug extract

The present invention relates to a herbal composition for preventing or treating respiratory cancer,

Constituent Content (% by weight) Neck 5 Sweet 5 Goat ginseng 30 Cordyceps 30 Jangseon bellflower 30

Example 1: Cytotoxicity test of extracts using lung cancer cell line A549

 To examine the cytotoxicity of the extracts of Lycoris chejuensis, Radix Salviae Radix Extract and Mixed Herbal Extracts prepared in Preparation Examples 1 and 2 to lung cancer cells, the following experiment was conducted.

Human lung carcinoma cell line A549 cells were cultured in RPMI 1640 medium supplemented with 10% FBS, 100 units / ml penicillin, 100 units / ml streptomycin and 0.25 / / ml amphotericin B at 37 ° C, And cultured in a 5% CO ₂ incubator.

The A549 cells cultured as described above were seeded on a 24-well plate at a density of 2 x 10 ⁴ cells / well. The extracts of Wakamatsu, Panax ginseng and Mixed herbal preparations prepared in Preparation Examples 1 and 2 were added at 0 ug / ml The cells were cultured in an incubator at 37 ° C in a 5% CO ₂ atmosphere for 24 hours at a concentration of 50 μg / ml, 100 μg / ml, 125 μg / ml, 250 μg / ml and 500 μg / The MTT solution was treated at a concentration of 0.5 mg / mL and reacted for 3 hours. The medium was then removed, dried at room temperature, dissolved in DMSO, and absorbance measured at 570 nm using an ELISA reader. The results of the experiment are shown in Figs.

As a result of the above test, it was confirmed that the extract of Wisteria extract showed a significant activity at about 150 ㎍ / ml through FIG. 1, and a significant activity at about 125 ㎍ / ml in the case of Dansamp I could. In addition, it was confirmed in FIG. 3 that the mixed herb extract had significant activity at about 200 / / ml.

From the above results, it was confirmed that the extracts of Lycopersicon esculentum and Candida were shown to be cytotoxic to lung cancer cells, and the extracts of mixed herbicidal products including Lycopersicon esculentum, Cordyceps,

Claims (8)

The present invention relates to a composition comprising, as an active ingredient, a herbal medicine ingredient of Korean cabbage, Korean cabbage, Chinese cabbage, Chinese cabbage,
A herbal composition for preventing or treating respiratory tract cancer, comprising 1 to 10% by weight of corn, 0.5 to 15% by weight of ginseng, 20 to 40% by weight of goat ginseng, 20 to 40% by weight of cordyceps, and 20 to 40% by weight of Jang Saeng Doraji. The method according to claim 1,
The composition may be selected from the group consisting of Chinese cabbage, Chinese cabbage, Chinese cabbage, Chinese cabbage, Chinese cabbage, Chinese cabbage, licorice, Chinese cabbage, dermis, taxa, Chinese cabbage, golden cabbage, , Ginger, ginger, ginseng, control, rhododendron, rhubarb, mint, mildew, ginseng, drowning, guisha, Wherein the composition further comprises at least one herbal medicine ingredient selected from the group consisting of sweet potato, prawn meat, keel, coriander, wax, sorghum, black potato, white porcelain, malt, The herbal composition for preventing or treating respiratory cancer according to claim 1, wherein said composition is an anti-cancer resonance section. The herbal composition for preventing or treating respiratory cancer according to claim 1, wherein the composition is an oral absorbent, a transdermal absorbent, a mucosal absorbent, an inhalant, a daphne, a non-smoked or an injection. The present invention relates to a composition comprising, as an active ingredient, a herbal medicine ingredient of Korean cabbage, Korean cabbage, Chinese cabbage, Chinese cabbage,
A health functional food for preventing or ameliorating respiratory cancer, comprising 1 to 10% by weight of tea seeds, 0.5 to 15% by weight of ginseng, 20 to 40% by weight of goat ginseng, 20 to 40% by weight of cordyceps, and 20 to 40% by weight of Jang Saeng Doraji. delete delete delete

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