KR101883826B1 - Injections of Therapeutic Agents - Google Patents

Abstract

Disclosed is a syringe for injecting a therapeutic substance.
According to an embodiment of the present invention, there is provided a syringe assembly coupled to a syringe for injecting a therapeutic material, the syringe assembly having a hollow cylindrical shape and including a fixed jaw line in the form of an internal projection, Wherein the insert is fixed to the fixed jaw line and includes a predetermined therapeutic material at the lower end of the insert, the insert being inserted into the housing and the housing.

Description

[0001] Injections of Therapeutic Agents [

BACKGROUND OF THE INVENTION 1. Field of the Invention [0001] The present invention relates to a syringe for injecting a therapeutic substance into a body using an air pressure inside a syringe.

The contents described in this section merely provide background information on the present embodiment and do not constitute the prior art.

Drug Delivery System is a drug delivery system that minimizes the side effects that occur in conventional methods when using medicines for the treatment of diseases or wounds of the human body and maximizes the therapeutic effects of medicines to efficiently deliver the necessary amount of medicines to the body A form that is designed to be delivered. Among the many kinds of drug delivery methods so far, the injection method using a needle is most often used due to its stability and efficiency.

Drug delivery systems using injection needles are capable of delivering accurate and efficient drugs, but they can also be used to prevent problems such as needle-phobia due to injection pain, the risk of infection due to reuse, and the occurrence of large amounts of medical waste Have. In particular, children with diabetes who need to take drugs at all times, such as childhood diabetes, are suffering from injection phobia, injection pain, and pain.

Various new methods such as powder injection, liquid jet injection and microneedle have been studied to develop a new drug delivery system that overcomes these problems, but there are still problems to be solved.

Among the various new methods developed, the piezoelectric actuator method is a method of injecting a drug liquid through a skin tissue by injecting a drug liquid at a high speed. Piezoelectric actuator methods were first developed in the 1930s and have been used to deliver many kinds of macromolecules, drugs and vaccines such as insulin and growth hormone into the body. However, this has also not been popularized due to problems such as splash back that occurs during drug liquid injection, instability of delivered drug volume and penetration depth, and considerable pain.

Accordingly, a micro jet injector using a laser induced shockwave has been recently developed. Particularly, among these methods, a biolistic method of directly accelerating microparticles and a drug jet delivery method of injecting a drug solution in the form of a jet can solve the biggest weaknesses of conventional systems, such as injection phobia, pain induction, It shows a lot of possibilities and is attracting much expectation.

However, the micro jet injector system using the laser induced shock wave has a problem that the edge of the separation membrane and the vicinity of the center of the separation membrane are damaged due to the rapid expansion of the separation membrane, and the burden is increased due to the high price.

An object of the present invention is to provide a syringe for injecting a therapeutic substance into a body by using a method of controlling the inflow of air by opening and closing the valve for inspiration and increasing the pressure inside the syringe have.

An object of the present invention is to provide a syringe for injecting a therapeutic substance, which is capable of delivering a therapeutic substance to a subcutaneous tissue in the body without involving pain.

It is an object of the present invention to provide a syringe for injecting a therapeutic substance, which prevents diseases and infections caused by reusing a syringe.

It is another object of the present invention to provide a syringe for injecting a therapeutic material at low cost and high efficiency by using a method using air pressure inside a syringe without using a separate apparatus.

According to an aspect of the present invention, there is provided a syringe assembly coupled to a syringe for injecting a therapeutic substance, the syringe assembly having a hollow cylindrical shape and including a fixed jaw line in the form of an internal projection, An insert inserted into the housing and the housing; the insert is fixed to the fixed jaw line and includes a predetermined therapeutic material at the lower end.

According to an aspect of the present invention, the syringe assembly further includes a syringe needle having an injection needle through-hole formed at the other end of the syringe assembly and exposed to the outside of the syringe assembly through the injection needle through-hole .

According to an aspect of the present invention, the fixed jaw line further includes a protrusion, and the insert further includes a concave groove, and the concave groove is seated on the protrusion.

According to one aspect of the present invention, there is provided a syringe for injecting a therapeutic substance into a body by injecting a therapeutic substance into the body by manipulating the pressure of air and a piston, the injector comprising: a syringe assembly; And a plunger coupled to one end of the inspiration valve and having a hollow cylindrical shape and a plunger inserted into one end of the barrel and linearly moving inside the barrel, Thereby providing a syringe for injecting a therapeutic substance.

According to an aspect of the present invention, the syringe assembly is characterized in that a body assembly is detachably coupled to one end.

According to an aspect of the present invention, the plunger includes a pushing bar that operates to move the inside of the barrel in a linearly movable manner.

According to an aspect of the present invention, the plunger includes a plunger positioned between the presser bar and the sealing member and extending to the opening of the barrel and the inspiration valve.

As described above, according to one aspect of the present invention, there is an advantage that the therapeutic material can be injected into the subcutaneous tissue by using the method of controlling the inflow of air by opening and closing the valve for inspiration and increasing the pressure inside the injector have.

According to an aspect of the present invention, the depth of the needle penetrating the skin is reduced by using a high pressure inside the syringe, and the therapeutic material can be injected into the subcutaneous tissue without accompanying pain.

According to an aspect of the present invention, there is an advantage that a syringe used once can have a structure that can not be reused, thereby preventing diseases and infections caused by reusing the syringe.

According to an aspect of the present invention, there is also provided an air compression method that does not require a chamber or a reinforcing member such as an elastic member necessary for filling a gas, thereby reducing the cost of consuming subsidiary materials, There is an advantage that a syringe for injection can be provided.

1 is a view showing a configuration of a syringe for injecting a therapeutic material according to an embodiment of the present invention.
2 is a cross-sectional view of a body assembly according to an embodiment of the present invention.
3 is a cross-sectional view of a syringe assembly in accordance with an embodiment of the present invention.
4 is a cross-sectional view of an insert inserted within a syringe assembly in accordance with an embodiment of the present invention.
5 is a cross-sectional view of an injection needle adapter according to an embodiment of the present invention.
6 is a view illustrating an embodiment of filling a therapeutic material using a therapeutic agent injecting syringe according to an embodiment of the present invention.
FIG. 7 is a view showing an embodiment of removing air inside a therapeutic agent injecting syringe according to an embodiment of the present invention.
FIG. 8 is a view illustrating an embodiment in which air is introduced into a therapeutic material injecting syringe according to an embodiment of the present invention.
FIG. 9 is a view showing an embodiment of injecting a therapeutic material inside a injector for injecting a therapeutic material into the outside according to an embodiment of the present invention.

While the invention is susceptible to various modifications and alternative forms, specific embodiments thereof are shown by way of example in the drawings and will herein be described in detail. It is to be understood, however, that the invention is not to be limited to the specific embodiments, but includes all modifications, equivalents, and alternatives falling within the spirit and scope of the invention. Like reference numerals are used for like elements in describing each drawing.

The terms first, second, A, B, etc. may be used to describe various elements, but the elements should not be limited by the terms. The terms are used only for the purpose of distinguishing one component from another. For example, without departing from the scope of the present invention, the first component may be referred to as a second component, and similarly, the second component may also be referred to as a first component. And / or < / RTI > includes any combination of a plurality of related listed items or any of a plurality of related listed items.

It is to be understood that when an element is referred to as being "connected" or "connected" to another element, it may be directly connected or connected to the other element, . On the other hand, when an element is referred to as being "directly connected" or "directly connected" to another element, it should be understood that there are no other elements in between.

The terminology used in this application is used only to describe a specific embodiment and is not intended to limit the invention. The singular expressions include plural expressions unless the context clearly dictates otherwise. It is to be understood that the term "comprises" or "having" in the present application does not preclude the presence or addition of features, numbers, steps, operations, components, parts, or combinations thereof described in the specification .

Unless otherwise defined, all terms used herein, including technical or scientific terms, have the same meaning as commonly understood by one of ordinary skill in the art to which this invention belongs.

Terms such as those defined in commonly used dictionaries are to be interpreted as having a meaning consistent with the contextual meaning of the related art and are to be interpreted as either ideal or overly formal in the sense of the present application Do not.

1 is a view showing a configuration of a syringe for injecting a therapeutic material according to an embodiment of the present invention.

A therapeutic agent injector 100 (hereinafter abbreviated as a " syringe ") includes a body assembly 110, a syringe assembly 120, and a needle needle adapter 130.

The body assembly 110 regulates the inflow of air into the syringe 100 and increases the air pressure inside the syringe 100 by performing piston motion.

The syringe assembly 120 is releasably coupled to the other end of the body assembly 110. The syringe assembly 120 includes a space into which the therapeutic material is introduced so that the syringe assembly 120 ejects the therapeutic material to the outside when the air pressure inside the syringe 100 is maximally increased by the main assembly 110. [

The needle adapter 130 is detachably coupled to the other end of the syringe assembly 120 to introduce therapeutic material into the syringe assembly 120.

A detailed description of each configuration of the therapeutic agent injecting syringe 100 will be given later in FIGS. 2 to 5.

2 is a cross-sectional view of a main assembly according to an embodiment of the present invention.

The body assembly 110 includes an inspiration valve 210, a barrel 220 and a plunger 230 inserted into the barrel 220.

The inspiration valve 210 may be detachably coupled to the other end of the barrel 220, and the coupling manner may be variously changed. The inspiration valve 210 regulates the inflow of air into the barrel 220 and the syringe assembly 120 by performing an opening and closing operation of introducing or discharging air using an air inlet (not shown). Air is injected into or discharged from the syringe 100 by opening or closing the air inlet by rotation of the inspiration valve 210. The inspiration valve 210 includes the contact members 212 and 214. The inspiration valve 210 is coupled to the other end of the barrel 220 and to one end of the syringe assembly 120 where the inserting members 212 and 214 are connected to the barrel 220 and the syringe assembly 120, So that it can be closely contacted with no gap. The contact members 212 and 214 may be made of a rubber material having soft and elastic properties, but are not limited thereto.

The barrel 220 includes an engagement portion 224, a flange 226, and a through hole 228. The barrel 220 is formed in a cylindrical shape having a hollow inside and an opening 222 disposed at the other end of the barrel 220 can be used as a passage of the plunger 232 when the plunger 230 is inserted . As described above, the inserting valve 210 is coupled to the engaging portion 224 located at the other end of the barrel 220. The flange 226 is disposed at one end of the barrel 130 and may be utilized as a gripping element or a support member when the user manipulates the syringe 100. The through hole 228 has an opening having a predetermined diameter and allows the plunger 230 to be inserted into the through hole 228.

The plunger 230 includes a plunger 232, a sealing member 234, and a presser bar 236. The diameter of the plunger 230 is smaller than the diameter of the through hole 228 of the barrel 220. [ The plunger 230 enters the through hole 134 of the barrel 130 and moves linearly within the barrel 130. [

At the other end of the plunger 230, a tapered rod 232 is formed. The plunger 232 moves up and down by an operation of pulling or pressing the presser bar 236. [ The plunger 232 passes through the openings 216 and 222 of the barrel 220 and the inspiration valve 210 and contacts the insert (not shown) inside the syringe assembly 120 to push the insert.

The sealing member 234 is formed of a soft and elastic material such as rubber or urethane so that the outer circumferential surface can be closely attached to the inner surface of the barrel 220. The sealing member 234 may be inserted into the barrel 220 to block the inflow of the therapeutic substance into the barrel 220 or the backflow thereof.

At one end of the plunger 230, a presser bar 236 is provided. The user can perform the piston operation in which the plunger 230 is moved up and down by holding the presser bar 236. [ When the user pulls the pusher 236 in the body direction (+ y-axis direction), the air pressure inside the syringe 100 is reduced and the therapeutic material (not shown) is introduced into the syringe assembly 120. Then, by the action of the user pressing the pressing member 236, the air inside the syringe 100 is compressed to the maximum. The movement of the presser bar 236 is performed in conjunction with the opening and closing operation of the inspiration valve 210, and the embodiment will be described in detail with reference to FIGS. 6 to 9. FIG.

3 is a cross-sectional view of a syringe assembly in accordance with an embodiment of the present invention.

The syringe assembly 120 includes an engagement portion 310, an insert 312, a fixed jaw line 314, a housing 316, and an injection needle 322.

The syringe assembly 120 may be formed in a cylindrical shape having a hollow interior and may be divided into an upper end portion 122 and a lower end portion 124 with reference to a fixed jaw line 314.

At one end of the syringe assembly 120, a coupling portion 310 is formed. The coupling portion 310 can be screwed to the inspiration valve 210, but the coupling manner can be changed. Meanwhile, the needle adapter 130 is detachably coupled to the other end of the syringe assembly 120.

The insert 312 is inserted into the housing 316 and a recessed groove (not shown) of the insert 312 is seated in a protrusion (not shown) of the fixed jaw line 314. The fixed jaw line 314 prevents the insert 312 from moving to the lower end 124 of the syringe assembly 120. A detailed description of the insert 312 will be given with reference to Fig.

4 is a cross-sectional view of an insert inserted into the syringe assembly.

When the insert 312 is moved from the upper end 122 to the lower end 124 of the syringe assembly 120 the tip of the insert 312 has a predetermined shape with a predetermined angle Lt; / RTI > The length of the insert 312 may vary depending on the volume of the therapeutic material. That is, the short length insert 312 increases the volume of the infusion healing material by reducing the volume occupying the lower end portion 124. When the relatively long insert 312 is inserted, the volume of the therapeutic material flowing into the interior decreases because the volume of the insert 312 occupying the lower end portion 124 increases.

The insert 312 injects the therapeutic material outward by the pressure of the air inside the syringe 100 and the piston manipulation of the body assembly 110. As described above, the insert 312 is fixed to the fixed jaw line 314. However, when the user locks the inspiration valve 210 and pulls the presser bar 236 in order to introduce the therapeutic material into the lower end 124, the insert 312 is moved from the fixed jaw line 314 to the upper end 122 ). Then, by the user opening the valve for inspiration 210 and pressing the presser bar 236 of the main assembly 110, the bar 232 contacts the insert 312 and moves the insert 312 to the fixed jaw line 314, and at the same time, the air introduced into the lower end portion 124 is removed.

Further, the insert 312 injects the therapeutic material introduced into the lower end portion 124 to the outside. With the inspiration valve 210 still open, the user retracts the pusher 236 to introduce air into the barrel 220 and the upper end 122. When the inspiration valve 210 is switched to the locked state in the state where the air is introduced, the air pressure inside the syringe 100 is increased. The insert 312 is subjected to air pressure so that the user can press the pushbutton 236 to contact the pushbutton 232 with the insert 312 so that the insert 312 can leave the fixed bezel 314 do. The insert 312 injects the therapeutic material outward by contacting the bar 232 with the air pressure of the barrel 220 and the upper end 122. The operation of the insert 312 according to the operation of the main assembly 110 will be described in detail with reference to FIGS. 6 to 9. FIG.

Referring again to FIG. 3, the injection needle 322 extends to the injection needle through-hole 320 provided in the syringe assembly 120 and is exposed to the outside. Typically, a conventional needle will allow the length of the needle to lengthen the length of the subcutaneous tissue within the skin, allowing the drug to reach the subcutaneous tissue directly. The injection needle 320 according to the embodiment of the present invention is formed in a shape shorter than a general injection needle and the depth of the injection needle 320 penetrating the user's skin is about 0.5 to 1.0 mm. Therefore, when the injection needle 320 is inserted into the body, the user can hardly feel the pain. In addition, since the injection needle 320 penetrates only part of the subcutaneous tissue and injects the therapeutic substance into the subcutaneous tissue with a strong force, the therapeutic substance can be delivered to the subcutaneous tissue without being fried or repelled. In principle, the injection needle 320 inserted into the body is not reused for the purpose of preventing the loss of function or infection.

5 is a cross-sectional view of an injection needle adapter according to an embodiment of the present invention.

The injector adapter 130 includes a coupling portion 410 and an injecting liquid filling portion 412. The coupling portion 410 has a structure that can be screwed with the other end of the syringe assembly 120.

The injector 412 may be embodied in a hollow form to introduce the therapeutic material into the syringe assembly 120. A user manipulates the main assembly 110 to insert the injected solution filling part 412 into an ampule or the like containing a therapeutic material (not shown) Allow the material to be filled. The details of filling the therapeutic material into the syringe assembly 120 will be described later with reference to FIG.

FIG. 6 is a view showing an embodiment of filling an injection with a therapeutic agent injecting syringe according to an embodiment of the present invention.

6A, the therapeutic substance injecting syringe 100 is a combination of the body assembly 110, the inspiration valve 210 and the syringe assembly 120, . ≪ / RTI > In order to fill the therapeutic material 510 using the syringe 100, the user switches the valve for inspiration 210 to the locked state. The upper portion of the syringe assembly 120 including the barrel 220 with respect to the fixed jaw line 314 of the syringe assembly 120 is blocked by the venting of the inspiratory valve 210, It becomes a sealed state.

Referring to FIG. 6 (b), in a state in which the air inlet 218 is closed by the valve for inserting 210, the user pulls the presser 236. At this time, the insert 312 fixed to the fixed jaw line 314 by the pressure difference inside the syringe assembly 120 is pushed by the upper end 122 of the syringe assembly 120, and the lower end of the syringe assembly 120 124, the therapeutic material 510 is introduced. 4, the volume of the therapeutic material 510 to be inserted into the body may be adjusted according to the length of the insert 312. [

FIG. 7 illustrates an embodiment of removing air within a syringe assembly according to an embodiment of the present invention. Referring to FIG.

When the therapeutic material 510 is sufficiently introduced into the syringe assembly 120, the syringe adapter 130 is separated from the syringe assembly 120. In order to push the insert 312 pushed rearward of the fixed jaw line 314 by the pressure by the pusher 232 and fix it to the fixed jaw line 314 again, The valve 210 is switched from the locked state to the open state. Then, the user presses the pushbutton 236 so that the plunger 230 is directed to the other end of the barrel 220. The insert 312 is pushed by the plunger 232 in the direction of the lower end 124 of the syringe assembly 120 and seated in the fixed chin line 314 to remove the air introduced into the lower end 124.

FIG. 8 is a view illustrating an embodiment in which air is introduced into a therapeutic material injecting syringe according to an embodiment of the present invention.

8, air can be introduced into the upper end 122 of the syringe assembly 120 and into the barrel 220 in order to use the pressure of air to inject the therapeutic material 510 outwardly. So that the pressure bar 236 is pulled. As a result, air is introduced into the upper end portion 122 of the syringe assembly 120 and the barrel 220 to increase the amount of air, thereby securing an amount of air that can be provided to the insert 312 later.

FIG. 9 is a view showing an embodiment of injecting a therapeutic material inside a injector for injecting a therapeutic material into the outside according to an embodiment of the present invention.

As shown in FIG. 9 (a), the user switches the valve for inspiration 210 to the locked state such that the air that has flowed into the upper part of the syringe assembly 120 and into the barrel 220 is not discharged. The air inlet 218 is shut off by the inspiration valve 210 so that the inside of the syringe 100 is sealed with the air pressure increased.

9 (b) to 9 (c), the upper end 122 of the syringe assembly 120 and the barrel 220 are closed, as the inspiration valve 210 is switched to the locked state in the air- The amount of air inside is increased, and the pressure received by the insert 312 is increased by the amount of increased air. The insert 312 must be detached from the fixed jaw line 314 in order to eject the therapeutic material 510. At this time, the user presses the pusher 236 to bring the pusher 232 and the insert 312 into contact with each other. The insert 312 ejects the therapeutic material 510 out while leaving the lower end 124 of the syringe assembly 120 by the pressure of the air and contact of the pusher 232. That is, the injector 100 for injecting a therapeutic substance according to an embodiment of the present invention uses a method of using the pressure of air without reinforcement such as a gas filling chamber or an elastic member for injecting the therapeutic substance 510, The therapeutic material 510 can be effectively injected into the body without consuming the therapeutic agent. At the same time, the injection needle 322 is inserted into the body of the user, and the therapeutic material 510 can be transferred to the subcutaneous tissue without being fried or leaking out. As the syringe assembly 120 is structurally used once, the insert 312 can not be released and reused at the lower end 124, and the injection needle 322 is also not reused for functional reasons such as loss of function, infection and disease prevention In principle.

The foregoing description is merely illustrative of the technical idea of the present embodiment, and various modifications and changes may be made to those skilled in the art without departing from the essential characteristics of the embodiments. Therefore, the present embodiments are to be construed as illustrative rather than restrictive, and the scope of the technical idea of the present embodiment is not limited by these embodiments. The scope of protection of the present embodiment should be construed according to the following claims, and all technical ideas within the scope of equivalents thereof should be construed as being included in the scope of the present invention.

100: Syringe for injecting therapeutic substance
110: body assembly
120: Syringe assembly
122:
124: Lower end
130: Needle adapter
210: Valve for inspiration
212, 214:
216: opening
220: Barrel
222: opening
224:
226: Flange
228: Through hole
230: plunger
232: Pusher
234: sealing member
236: Presser
310:
312: insert
314: Fixed chin line
316: Housing
318:
320: Needle penetration needle
322: needles
410:
412:
510: Therapeutic substance

Claims (7)

A syringe assembly coupled to a therapeutic material injection syringe,
A housing having a hollow cylindrical shape and including a fixed jaw line in the form of a projection in the inside, the housing being divided into an upper portion and a lower portion based on the fixed jaw line; And
An insert inserted into the housing and fixed to the fixed jaw line and separated from the lower end by physical contact from the outside,
Wherein air is introduced into the upper portion and a predetermined therapeutic material is introduced into the lower portion. The method according to claim 1,
The syringe assembly includes:
Further comprising an injection needle having an injection needle through-hole formed at the other end of the syringe assembly and exposed through the injection needle through-hole to the exterior of the syringe assembly. The method according to claim 1,
Wherein the fixed jaw line further comprises a protrusion, wherein the insert further comprises a concave groove, the concave groove being seated in the protrusion. 1. A syringe for injecting a therapeutic substance into a body by pressurizing air and manipulating the piston,
A syringe assembly of claim 1;
An inspiratory valve coupled to one end of the syringe assembly for regulating inflow and outflow of air by an air inlet;
A barrel coupled to one end of the inspiratory valve and having a hollow cylindrical shape; And
A plunger inserted into one end of the barrel and linearly moving inside the barrel;
Wherein the injector is configured to inject a therapeutic material into the syringe. 5. The method of claim 4,
The syringe assembly includes:
Wherein the body assembly is detachably coupled to the one end. 6. The method of claim 5,
The plunger,
And a pushbutton for moving the inside of the barrel so as to move linearly movably. The method according to claim 6,
The plunger,
And a plunger positioned between the pushing piece and the sealing member and extending into the opening of the barrel and the inspiration valve.

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