KR101832850B1 - Method for the preparation of 3,3-bis-[bis-(2-methoxyphenyl)phosphanylmethyl]-1,5-dioxy -spiro [5,5] undecane and their derivatives - Google Patents

Abstract

The present invention relates to a process for the preparation of 3,3-bis- [bis- (2-methoxyphenyl) phosphanylmethyl] -1,5-dioxy-spiro [5,5 ] Undecane and derivatives thereof, and relates to a safe and efficient production method in mass production.

Description

Method for preparing 3,3-bis [bis- (2-methoxyphenyl) phosphinylmethyl] -1,5-dioxy-spiro [5,5] undecane and its derivatives [ 3-bis- [bis- (2-methoxyphenyl) phosphanylmethyl] -1,5-dioxy-spiro [5,5] undecane and their derivatives.

The present invention relates to a process for the preparation of 3,3-bis- [bis- (2-methoxyphenyl) phosphanylmethyl] -1,5-dioxy-spiro [5,5 ] Undecane and derivatives thereof.

Copolymers of carbon monoxide and olefins are known as polyketones. The polyketone is excellent in mechanical properties and thermal properties, and is excellent in abrasion resistance and chemical resistance, and is useful for various applications. Especially, it is widely used as a raw material for high strength fibers and engineering plastics.

In order to produce high molecular weight polyketones having such high physical properties, various catalysts have been disclosed to date. The initial catalyst of this polymerization reaction was disclosed in U.S. Patent No. 2,577,208 in 1951. When ethylene and carbon monoxide were reacted in water using K ₂ Ni (CN) ₄ as a catalyst, a low molecular weight oligomer was reacted with diethyl ketone and propyl Lt; RTI ID = 0.0 > acid. ≪ / RTI > Highly active catalysts that have been commercially viable since then were developed by Shell in the 1980s and the highly active catalysts claimed by Shell included two non-coordinating anions of palladium divalent ions coordinated by bidentate phosphine ligands / RTI > Since the 1,3-bis [di (o - methoxyphenyl) phosphino] propane-2-sila {1,3-bis [di (o -methoxyphenyl) phosphino] -2-silapropane} a ligand is coordinated to a palladium compound (U.S. Patent No. 4,994,592 (1991)) discloses a carbon monoxide / ethylene copolymerization reaction.

Japanese Patent Publication No. 4-227726 discloses a catalyst comprising palladium and 2- (2,2,4,6-trimethylbenzene) -1,3-bis [di (2-methoxyphenyl) phosphino] propane and an anion Japanese Patent Publication No. 5-140301 discloses a method using palladium and a catalyst comprising 2-hydroxy-1,3-bis [di (2-methoxyphenyl) phosphino] propane and an anion as a ligand have. As a ligand to be used as a constituent of such a catalyst, a phosphorus ligand is mainly used. However, the phosphorus ligand has many problems in terms of economy and safety because it is difficult to synthesize and expensive.

In order to solve this problem, Korean Patent No. 10-1546034 discloses a method for producing phosphorus ligand by using sodium hydroxide. However, this method is still inferior in stability and low cost due to low yield The problem can not be solved, and besides, there is a problem that it can not be widely used according to the substitution of the phosphorus ligand.

Currently known and widely used ligands have three structures as shown below, and they are reported to ferment a high polymerization activity. However, their commercial synthesis is not easy and they are expensive.

   &Lt; Formula 1 > < EMI ID =

US 2577208 A US 4994592 A JP 04-227726 A JP 05-140301 A WO 2001-002463 A1 WO 2013-141458 A1 US 4874897 A

The object of the present invention is to provide a method for mass production of phosphorus ligands by using a base capable of commercial mass production and solving the above problems in the production of ligands which are major constituents of catalysts for the production of polyketones. Accordingly, it is desired to provide an economical method for securing stability in the production of phosphorus ligand.

It is another object of the present invention to provide a method for preparing a phosphorus ligand which can be generally applied despite the variety of the chemical structure of the phosphorus ligand.

The present invention relates to a process for preparing a phosphorus ligand for a polyketone polymerization catalyst comprising the step of reacting a bis (2-methoxyphenyl) phosphine represented by the following formula (4) with a metal alkoxide to obtain a phosphorus ligand compound represented by the following formula to provide.

&Lt; Formula 4 >

&Lt; Formula 5 >

을 나타내고, R₁은 수소, C_1-6 알킬기 또는 서로 결합하여 사이클로헥산을 형성한다.)(In the above formula (4) or (5), R is hydrogen, a C _1-6 alkyl group or R

And R &lt; ₁ &gt; represents hydrogen, a _C1-6 alkyl group or a group bonded to each other to form cyclohexane.

More specifically, a production method in the case where the phosphorus ligand compound represented by Chemical Formula 5 is any one of Chemical Formulas 1 to 3 is preferable.

  &Lt; Formula 1 > < EMI ID =

The present invention also relates to a process for preparing the metal alkoxide, wherein the metal alkoxide is sodium methoxide, sodium ethoxide, sodium butoxide, sodium t-butoxide, potassium methoxide, potassium ethoxide, potassium butoxide or potassium t- to provide. A more preferred metal alkoxide is sodium t-butoxide or potassium t-butoxide.

In the present invention, the solvent of the above reaction is preferably selected from the group consisting of tetrahydrofuran (THF), dimethylsulfoxide (DMSO), dimethylformamide (DMF), and dimethylacetamide (DMAC).

The present invention provides a method for mass production of a ligand to be used for a polyketone polymerization catalyst and a method for producing a phosphorus ligand by a safe method so as to reduce the production cost of the ligand, The present invention provides a production method capable of safely and mass-producing various kinds of phosphorus ligands using an alkoxide as a base instead of a dangerous production condition.

Hereinafter, embodiments of the present invention will be described in detail. In the following description of the present invention, a detailed description of known functions and configurations incorporated herein will be omitted when it may make the subject matter of the present invention rather unclear.

The following examples are illustrative of the present invention and are not intended to limit the scope of the present invention.

The reaction according to the preparation method provided by the present invention can be represented by the following reaction formula (1). The following scheme shows the reaction of the phosphorus ligand compound of Formula 1, which is one of the phosphorus ligands.

<Reaction Scheme 1>

                                                 &Lt; Formula 1 >

The preparation of the intermediate 5,5-bis (bromomethyl) -2,2-dimethyl-1,3-dioxane in the preparation of the compound of formula 1 can be carried out by the method disclosed in the prior art WO 2001002463A1, To remove water.

<Reaction Scheme 2>

Bis-bromomethyl-1,5-dioxa-spiro [5.5] undecane can be easily obtained even at room temperature by using 1,1-dimethoxycyclohexane instead of cyclohexanone as a milder method than the above- .

<Reaction Scheme 3>

(1) was prepared by a milder method using a metal alkoxide instead of lithium or NaH used in the prior art as a method for preparing the compound of formula (1). The metal alkoxide used in the present invention may be selected from the group consisting of potassium tert-butoxide, sodium tert-butoxide, potassium butoxide, sodium butoxide, Several metal alkoxides such as sodium methoxide and sodium ethoxide were used. The most favorable results were obtained when using potassium tert-butoxide, sodium tert-butoxide and two kinds of alkoxides.

The metal alkoxide is used in an amount of 1 to 5 equivalents based on bis- (2-methoxyphenyl) phosphine, preferably 1 to 2 equivalents, based on the bis- (2-methoxyphenyl) phosphine , 1.2 equivalents is most preferred. As a solvent to be used, any one or more of tetrahydrofuran (THF), dimethylsulfoxide (DMSO), dimethylformamide (DMF) and dimethylacetamide (DMAC) are mixed and DMSO is used desirable.

[ Example  One]

3,3-bis- bromomethyl -1,5- dioxane - spiro [5.5] undecane  Manufacturing method

52.4 g of 2,2-bis (bromomethyl) -1,3-propanediol and 19.6 g of cyclohexanone are added to 200 mL of toluene, and methanesulfonic acid or sulfuric acid is added in a catalytic amount and refluxed for 3-5 hours. At this time, water is removed (3.6 mL) and the completion of the reaction is confirmed.

200 mL of sodium bicarbonate was added, followed by washing, drying with a desiccant, filtration and distillation.

_{^{1 H NMR (CDCl 3):}} 3.87 (s, 4H), 3.57 (s, 4H), 1.76 (bs, 4H), 1.45 (bs, 4H), 1.35 (bs, 2H)

3,3- Bis - [ Bis -(2- Methoxyphenyl ) Phosphanylmethyl ] -1,5- Deoxy - Spyro [5,5] undecane  Manufacturing method

Dissolve 695 g of 3,3-bis-bromomethyl-1,5-dioxane-spiro [5.5] undecane in 10 L of DMSO, breathe nitrogen while maintaining the internal temperature at room temperature, and add 545 g of potassium tert-butoxide. Then, 1 kg of bis- (2-methoxyphenyl) phosphane is dissolved in DMSO 2 L, the solution is slowly added to the reactor, and the solution is stirred for 3-5 hours at 15-20 ° C. Add 15 L of methylene chloride to the reactor, and add 15 L of water while maintaining the temperature at 10-15 ° C. After layer separation, the organic layer is washed with 10 L of 10% brine solution and dried using a desiccant. After filtration, the organic solvent is distilled off and 5 L of methanol is added to form crystals. After stirring at room temperature for 2 hours, the mixture was filtered, washed with 1 L of methanol and dried in vacuo to give 3,3-bis- [bis- (2-methoxyphenyl) phosphanylmethyl] -1,5-dioxi-spiro [ 5,5] undecane (yield: 70%).

¹ H NMR (CDCl ₃ ): 7.20-7.10 (m, 8H), 6.87-6.78 (m, 8H), 3.87 (s, 4H) , 4H), 1.45 (bs, 4H), 1.35 (bs, 2H)

_{^{1 P NMR (CDCl 3):}} -46.65

[ Example  2]

5,5- Bis - bromomethyl -2,2- dimethyl -[One, 3] dioxane  Manufacturing method

50 g of 2,2-bis (bromo-methyl) -1,3-propanediol and 22 g of acetone are added to 200 mL of toluene, and methanesulfonic acid or sulfuric acid is added in a catalytic amount and refluxed for 3-5 hours. At this time, water is removed (3.6 mL) and the completion of the reaction is confirmed.

200 mL of sodium bicarbonate was added, followed by washing, drying with a desiccant, filtration and distillation.

¹ H NMR (CDCl ₃ ): 3.79 (s, 4H), 3.57 (s, 4H), 1.41

5,5- Bis - {[bis- (2- 메틸oxy -phenyl) - 포스탄 ] -methyl} -2,2- dimethyl -[One, 3] dioxane  Manufacturing method

Dissolve 61 g of 5,5-bis-bromomethyl-2,2-dimethyl- [1,3] dioxane in 1 L of DMSO, blow nitrogen into it while keeping the internal temperature at room temperature, and add 55 g of potassium tert-butoxide. Then, 100 g of bis- (2-methoxyphenyl) phosphane is dissolved in DMSO 2 L, the solution is slowly added to the reactor, and the mixture is stirred for 3-5 hours at 15-20 ° C. Add 1.2 L of methylene chloride to the reactor and add 1.5 L of water while maintaining the temperature at 10-15 ° C. After layer separation, wash the organic layer with 1 L of 10% brine solution, dry with a desiccant, and filter. Distill the organic solvent and add 0.5 L of methanol to form crystals. The mixture was stirred at room temperature for 2 hours, filtered, washed with 0.3 L of methanol and dried in vacuo to give 5,5-Bis - {[bis- (2-methoxy-phenyl) -phosphanyl] -methyl} -2,2- 1,3] dioxane (68%).

¹ H NMR (CDCl ₃ ): 7.20-7.10 (m, 8H), 6.87-6.78 (m, 8H), 3.92 (s, 4H) , &Lt; / RTI &gt; 4H), 1.44 (s, 6H)

_{^{1 P NMR (CDCl 3):}} -46.04

The foregoing description is merely illustrative of the present invention, and various modifications may be made without departing from the essential characteristics of the present invention. Accordingly, the embodiments disclosed herein are intended to be illustrative rather than limiting, and the spirit and scope of the present invention is not limited by these embodiments. The scope of protection of the present invention should be construed according to the following claims, and all techniques within the scope of the same should be construed as being included in the scope of the present invention.

Claims (10)

Reacting a bis (2-methoxyphenyl) phosphine represented by the following formula (4) with a metal alkoxide to obtain a phosphorus ligand compound represented by the following formula (5)
Wherein the metal alkoxide is potassium t-butoxide, and 1 to 2 equivalents are used.
&Lt; Formula 4 >< EMI ID =

(In the above formula (4) or (5), R is bonded to R

And R &lt; ₁ &gt; are bonded to each other to form cyclohexane.)
delete delete delete delete delete delete The process according to claim 1, wherein the solvent of the reaction is selected from the group consisting of tetrahydrofuran (THF), dimethylsulfoxide (DMSO), dimethylformamide (DMF), dimethylacetamide delete delete