KR101820835B1 - Dual type nebulizer - Google Patents

Abstract

The present invention relates to a dual type nebulizer with a medicine selecting function, capable of automatically applying power through a switching unit, which is automatically operated by inhaling force applied by a user through a mouthpiece, and enabling the user to inhale gasified medicines containing beneficial components, while storing a plurality of medicines and enabling the user to choose a medicine considering a medicinal effect or a mood of the user. The present invention includes: a body; a mouthpiece; a power supply unit; a gasifying unit; a guide member; an anodic body and a cathodic body; and a switching slider. The switching slider is configured to turn on or off the power supply unit to supply or cut off power to the gasifying unit by connection between the anodic body and the cathodic body. The gasifying unit is able to inhale an aerosol generated from one or two kinds of medicines stored in a cartridge.

Description

DUAL TYPE NEBULIZER < RTI ID = 0.0 >

More particularly, the present invention relates to a portable nibilizer, and more particularly, to a portable nibilizer in which when a user applies a suction force through a mouthpiece, a switching unit is automatically operated by a suction force to apply a power source, and a medicine having a beneficial component is vaporized, The present invention also relates to a dual type nebulizer capable of selectively sucking a desired drug in consideration of the user's mood or medicinal effect while accommodating a plurality of medicines.

In general, although cigarettes are a delicacy, it is well known that it causes various diseases in human body. Nonetheless, in the case of smokers, it is one of the toughest tasks to stop smoking cigarettes that have been habitually habituated due to social diversity and interpersonal relationships. In particular, tobacco contains various harmful substances such as nicotine and tar, which are various carcinogenic substances, and causes various diseases such as lung cancer and circulatory diseases (Burger's disease caused by laryngeal cancer and vasoconstriction) and death, People are suffering from secondhand smoke.

Therefore, although the smoking cessation movement is spreading socially widely, the smokers who have already smoked are not easily able to break due to their addictive and addictive nature, so they are not doing much good.

Recently, many aids such as smoking cigarettes and smoking pipes have been developed and commercialized to help quit cigarettes. In the case of smoking cigarettes, most of the cigarettes are consumed or the smell unique to the cigarettes is lost, Smoking cigarettes are being gradually phased out.

However, this electronic cigarette has recently been controversial. Therefore, a variety of Neblies have been developed that can generate and inhale aerosols by vaporizing herbal medicines or naturally occurring ingredients, which are beneficial to the human body, instead of nicotine.

Conventionally, when a user presses a switch button provided directly on a nebulizer main body or an air flow sensor or a switching device provided inside the nebulizer body senses a suction force, the conventional nebulizer applies power to a heating heater, an ultrasonic vibrator, a high frequency oscillator, The aerosol is generated by heating or ultrasonic vibration, and the generated aerosol is discharged through the nozzle of the mouthpiece so that the user can inhale the aerosol.

However, in such a conventional nebulizer, the air flow sensor or the switch device for operating the power supply device should not obstruct the suction of the aerosol, so that the air flow sensor is disposed behind the area where the aerosol is generated, And it is difficult for a user having asthma or a weak suction force to use it because of a large suction force.

In addition, since conventional nebulizers uniformly supply aerosols generated from a single medicament contained therein, it is impossible to select a kind of medicament to be inhaled in consideration of the mood or the efficacy of the user.

Korean Patent Registration No. 1039837 (June 1, 2011) Korean Patent Publication No. 2014-0125249 (Oct. 28, 2014)

SUMMARY OF THE INVENTION The present invention has been made to solve the above-mentioned conventional problems, and it is an object of the present invention to provide a device and a method for operating the switching unit by a suction force when a user applies a suction force through a mouthpiece, The present invention provides a dual type nebulizer that allows a user to inhale a drug while allowing the user to inhale the drug while taking into consideration the mood or the efficacy of the user while accommodating a plurality of medicines.

According to an aspect of the present invention, there is provided a dual type Nebulizer comprising: a main body; A mouthpiece having a discharge port through which vaporized aerosol is discharged; A power supply unit installed in the main body; A vaporization unit for vaporizing the medicine by a power source applied by the power supply unit; A guide member formed to communicate with the discharge port and having a through hole through which the aerosol can flow; An anode electrode member and a cathode electrode member made of a conductive material and electrically connected to the power supply unit on an inner surface of the guide member; The air electrode assembly is slidably installed on the guide member and moves by the air suction force generated through the discharge port to electrically connect the anode electrode assembly and the cathode electrode assembly while being in contact with the anode electrode assembly and the cathode electrode assembly, And a switching slider having a through hole through which air and an aerosol pass is formed so as to penetrate through the communication hole communicating with the vent hole when the switching slider is in contact with the switching slider, The power supply unit is turned on or off to supply or cut off power to the vaporization unit. The vaporization unit includes a first chamber and a second chamber formed by intermediate partition walls, A plurality of discharge ports formed to communicate with one end of the cartridge and through which the aerosol is discharged; A first ultrasonic vibrator and a second ultrasonic vibrator for ultrasonically vibrating the medicine supplied into the aerosol generating unit, wherein one of the first ultrasonic vibrator and the second ultrasonic vibrator is operated And a selection switch for selecting both to operate, so that the aerosol generated from any one or both of the two types of medicines contained in the cartridge can be sucked.

According to the present invention, when the user applies a suction force to the mouthpiece, the switching slider moves and the anode electrode assembly and the cathode electrode assembly are electrically connected to each other to perform a switching operation to supply power to the vaporization unit, Can be discharged to the discharge port through the switching slider, the anode electrode body, and the cathode electrode body implementing the switching operation.

Therefore, the vaporizing unit can operate at almost the same time as the suction of the user, so that the vaporized aerosol can be sucked, so that a sufficient amount of the aerosol can be sucked even with a weak suction force.

Further, since the present invention can accommodate a plurality of medicines having different medicinal effects or different flavors or fragrances, the medicines can be sucked in an aerosol form by selecting a desired one of the medicines. Therefore, in order to maximize the medicinal effect, It is possible.

BRIEF DESCRIPTION OF THE DRAWINGS FIG. 1 is a cross-sectional view schematically showing the overall configuration of a dual type four-blader according to an embodiment of the present invention; FIG.
Fig. 2 is a cross-sectional view showing a main part of the dual type four-blader shown in Fig. 1, showing a pre-suction state.
FIGS. 3 to 6 are reference views for explaining the operation of the dual type Nebulizer according to one embodiment of the present invention.

A dual type nebulizer according to embodiments of the present invention will be described in detail with reference to the accompanying drawings. The present invention is capable of various modifications and various forms, and specific embodiments are illustrated in the drawings and described in detail in the text. It is to be understood, however, that the invention is not intended to be limited to the particular forms disclosed, but on the contrary, is intended to cover all modifications, equivalents, and alternatives falling within the spirit and scope of the invention. Like reference numerals are used for like elements in describing each drawing. In the accompanying drawings, the dimensions of the structures are enlarged to illustrate the present invention, and are actually shown in a smaller scale than the actual dimensions in order to understand the schematic structure.

Also, the terms first and second, etc. may be used to describe various components, but the components should not be limited by the terms. The terms are used only for the purpose of distinguishing one component from another. For example, without departing from the scope of the present invention, the first component may be referred to as a second component, and similarly, the second component may also be referred to as a first component. On the other hand, unless otherwise defined, all terms used herein, including technical or scientific terms, have the same meaning as commonly understood by one of ordinary skill in the art to which this invention belongs. Terms such as those defined in commonly used dictionaries are to be interpreted as having a meaning consistent with the contextual meaning of the related art and are to be interpreted as either ideal or overly formal in the sense of the present application Do not.

Hereinafter, a dual type nebulizer according to a preferred embodiment of the present invention will be described in detail with reference to the accompanying drawings.

Referring to FIGS. 1 to 3, the dual type Nebulizer according to an embodiment of the present invention includes a hollow main body 10, a mouthpiece 20 installed at a rear end of the main body 10, , A power supply unit (30) installed in the main body, a vaporization unit (40) for vaporizing the medicine by a power source applied by the power supply unit (30) A cylindrical switching slider 70 made of a conductive material and slidable in the front-rear direction inside the guide member 50; a switching slider 70 disposed inside the guide member 50, And an anode electrode assembly 61 and a cathode electrode assembly 62 that are electrically connected to each other while being in contact with the slider 70 to allow the power supply unit 30 to supply power to the vaporization unit 40. [

The main body 10 may have a hollow circular tube shape, but may have various shapes such as a polygonal shape such as a rectangular parallelepiped or a shape such as a tobacco pipe.

At the rear end of the main body 10, a mouthpiece 20 functioning as a nozzle for sucking the aerosol generated in the main body 10 by the user's mouth is provided. The mouthpiece 20 may be made separately from the body 10, but may otherwise be made integral with the body 10. The mouthpiece 20 is made of a material which is harmless to the human body because it is a portion to be sucked and sucked by the user. For example, the mouthpiece 20 may be made of a soft silicone resin or a material in which silicon and oxygen or organic materials are mixed with each other.

The mouthpiece (20) is formed with a discharge port (21) through which the aerosol is discharged so as to extend in the front and rear direction. The front end of the discharge port (21) communicates with the rear end of the guide member (50).

When the switching slider 70 and the anode electrode assembly 61 and the cathode electrode assembly 62 are in contact with each other and are electrically connected to each other, that is, when the switching slider 70 is turned on, the power supply unit 30 supplies power to the vaporizing unit 40, And the power supply to the vaporizing unit 40 is cut off when the switching slider 70 is separated from the anode electrode assembly 61 and the cathode electrode assembly 62 and turned off. The power supply unit 30 includes a battery 31 installed in the main body 10 and a battery 31 electrically connected to the battery 31, the positive electrode member 61 and the negative electrode member 62, And a controller 32 for supplying or blocking power to the vaporization unit 40. [

The battery 31 may be a general battery, a lithium ion battery, or a rechargeable battery that can be charged repeatedly. The controller 32 supplies power to the battery 31 to various electrical components such as an LED or a display device and an electric circuit for supplying power to the vaporization unit 40 and the nibbler. And a circuit board (PCB) having a resistance element or the like.

The vaporization unit 40 serves to generate aerosols by vaporizing a liquid, a gel, or a solid drug by means of a power source applied by the power supply unit 30. The vaporization unit 40 may generate the aerosol by, for example, heating and vaporizing the medicament or atomizing the medicament by ultrasonic vibration or high frequency vibration. In this embodiment, the first ultrasonic vibrator 45a and the second ultrasonic vibrator 45b, which generate aerosols in an ultrasonic vibration system capable of atomizing the medicine within a short time, are applied to constitute the vaporization unit 40. [

More specifically, in this embodiment, the vaporization unit 40 includes a first chamber 41a and a second chamber 41b, which contain two kinds of medicines A and B, An aerosol generating part 42 formed to communicate with one end of the cartridge 41 and having a plurality of discharge ports 43 through which side aerosols are discharged from the side surface and the upper surface of the cartridge 41, And supplies the small amount of medicines A and B of the first chamber 41a and the second chamber 41b to the aerosol generating unit 42 by being disposed between the cartridge 41 and the aerosol generating unit 42 The first fibrous body 44a and the second fibrous body 44b are electrically connected to the controller 32 of the power supply unit 30 to form the first fibrous body 44a and the second fibrous body 44b, And a first ultrasonic vibrator 45a and a second ultrasonic vibrator 45b that ultrasonically vibrate the medicine supplied into the aerosol generating unit 42 along the first ultrasonic vibrator 45a.

It should be noted that the structure of the vaporization unit 40 includes a cartridge 41 having a first chamber 41a and a second chamber 41b so as to accommodate and atomize two kinds of medicines A and B in a liquid state ), A first fibrous body 44a and a second fibrous body 44b, a first ultrasonic vibrator 45a and a second ultrasonic vibrator 45b. According to such a configuration, it is possible for the user to suck at least one of two different kinds of medicines A and B or both medicines at the same time through the operation of the selection switch 90. The two kinds of drugs (A and B) may be provided with different effects on the premise that the best effects can be exhibited when they are inhaled simultaneously or at different time intervals. . Accordingly, various operations can be performed in order to maximize the effect of the drug or to take into account the preferences of the user.

When the above-mentioned medicament is in the form of a gel or a solid, it is preferable to use an exothermic body to heat the medicament to generate an aerosol rather than to use an ultrasonic vibrator in order to generate aerosol. The medicament may be made from a pharmaceutical composition having a component that can remove bad breath after a user smokes or may be useful to the human body. For example, the licorice, Angelica, And a pharmaceutical composition for prevention or treatment of pulmonary disease after inhalation smoking, which comprises a mixed extract as an active ingredient and at least one extract selected from the group consisting of bark, bamboo, bamboo, astragalus, gardenia and gold. This will be described in detail later. In addition, it is also possible to use various flavors such as mint, rosemary, basil, peppermint, juniper, geranium, clarysege, ylang ylang, lavendin, rosewood, lavender, lemon, chamomile, spearmint, bisgrain, pine needle, mir, , Jasmine, rose, geranium, grapefruit, patchouli, phytoncide herb, and the like.

The guide member 50 is connected to the front end of the discharge port 21 of the dental mouthpiece 20 in the form of a hollow circular tube whose front surface is opened. The guide member 50 may be formed separately from the mouthpiece 20 and connected to the discharge port 21 of the mouthpiece 20 but may be formed integrally with the mouthpiece 20 to be integrated with the discharge port 21 have.

A vent hole 51 through which the aerosol generated in the vaporization unit 40 can flow is formed on a side surface of the guide member 50. A plurality of vent holes 51 may be formed on the side surface of the guide member 50 at regular intervals along the circumferential direction. A flow guide 55 is formed between the guide member 50 and the main body 10 so as to guide the aerosol sucked toward the vent hole 51 in an inclined manner.

The switching slider 70 is in the form of a circular tube having an outer diameter slightly smaller than the inner diameter of the guide member 50 and is moved in the forward and backward direction from the inside of the guide member 50 by the air suction force generated through the discharge port 21 Slide. A plurality of communication holes 71 communicating with the air vent 51 of the guide member 50 are formed on the side surface of the switching slider 70 so as to be laterally penetrated. The communication hole 71 communicates with the vent hole 51 of the guide member 50 when the switching slider 70 moves backward from the inside of the guide member 50 and the switching slider 70 moves forward And is closed by the side surface of the guide member (50) while being displaced from the vent hole (51). A through hole 72 through which air and aerosol can pass is formed at the center of the rear surface of the switching slider 70.

The switching slider 70 receives an elastic force forward by the elastic member 80 provided inside the guide member 50. [ When the suction force is not applied through the discharge port 21 of the mouthpiece 20, the switching slider 70 is maintained in the forward movement state by the elastic force of the elastic member 80 and the suction force The elastic member 80 is elastically deformed and the switching slider 70 moves backward. The elastic member 80 is provided between the front end portion of the guide member 50 and the front end portion of the switching slider 70 and is a tension coil spring for applying an elastic force to pull the switching slider 70 forward A compression coil spring which is disposed behind the switching slider 70 and applies a forward pushing force to the switching slider 70 with respect to the guide member 50 may be alternatively formed as the elastic member 80. [

The switching slider 70 may be made of a conductive metal material having excellent electrical conductivity such as copper or the like. However, as shown in another embodiment of FIG. 4, the switching slider 70 may be made entirely of a resin material, And the cathode electrode member 62 are electrically connected to each other. The switching terminal 73 has a ring shape in which a through hole 72 through which air and an aerosol pass is formed in the center.

The anode electrode assembly 61 and the cathode electrode assembly 62 are electrically connected to the controller 32 of the power supply unit 30 through electric wires 63 and 64 respectively and are electrically connected to the controller 32 of the power supply unit 30, And are electrically connected to each other while being in contact with the rear surface of the switching slider 70 or the switching terminal 73 (see FIG. 4) mounted on the rear surface of the switching slider 70.

Since the anode electrode assembly 61 and the cathode electrode assembly 62 are spaced apart from each other by 180 ° and are installed to protrude inward in the radial direction on the rear side of the guide member 50, And also serves as a stopper for restricting the movement of the stopper 70.

The dual-type nebulizer of the present invention thus constructed operates as follows.

2, when the user first switches the selection switch 90 to select the medicine A and then sucks the mouthpiece 20 through the mouth, a suction force is applied to the guide member (not shown) through the discharge port 21 The switching slider 70 is moved to the rear side of the guide member 50 by overcoming the elastic force of the elastic member 80. [

The communicating hole 71 of the switching slider 70 and the vent hole 51 of the guide member 50 are aligned and communicated with each other as the switching slider 70 moves backward, The switching terminal 73 (see Fig. 4) provided on the rear surface of the switching slider 70 contacts the anode electrode body 61 and the cathode electrode body 62 while the anode electrode body 61 and the cathode electrode body 62 Are electrically connected. The electric circuit of the controller 32 is connected and the power of the battery 31 is applied to the first ultrasonic vibrator 45a of the vaporization unit 40 to operate the first ultrasonic vibrator 45a.

As the first ultrasonic vibrator 45a operates, the A agent supplied into the aerosol generating portion 42 through the first fibrous body 44a is atomized by the ultrasonic vibration to generate an aerosol. The generated aerosol is discharged to the inner space of the main body 10 through the discharge port 43 formed on the side surface and the upper surface of the aerosol generating portion 42 as shown in FIGS. 3 and 4, Through the communication hole 71 and the through hole 72 of the switching slider 70 and then through the discharge port 21 to be sucked by the user.

When the user stops the suction, the switching slider 70 moves forward by the elastic force of the elastic member 80 and returns to the initial position. The communication hole 71 of the switching slider 70 is guided by the guide member 50, As shown in Fig.

On the other hand, when the user switches the selection switch 90 to select the medicine B and then sucks the mouthpiece 20 through the mouth in a state as shown in FIG. 2, the suction force is transmitted through the discharge port 21 to the inside of the guide member 50 And is transmitted to the switching slider 70 so that the switching slider 70 overcomes the elastic force of the elastic member 80 and moves to the rear side of the guide member 50. [

The communicating hole 71 of the switching slider 70 and the vent hole 51 of the guide member 50 are aligned and communicated with each other as the switching slider 70 moves backward, The switching terminal 73 (see Fig. 6) provided on the rear surface of the switching slider 70 contacts the anode electrode body 61 and the cathode electrode body 62 while the anode electrode body 61 and the cathode electrode body 62 Are electrically connected. The electric circuit of the controller 32 is connected and the power of the battery 31 is applied to the second ultrasonic vibrator 45b of the vaporization unit 40 to operate the second ultrasonic vibrator 45b.

As the second ultrasonic vibrator 45b operates, the B medicine supplied into the aerosol generating portion 42 through the second fibrous body 44b is atomized by the ultrasonic vibration to generate an aerosol. As shown in FIGS. 5 and 6, the generated aerosol is discharged to the inner space of the main body 10 through the discharge port 43 formed on the side surface and the upper surface of the aerosol generating portion 42, Through the communication hole 71 and the through hole 72 of the switching slider 70 and then through the discharge port 21 to be sucked by the user.

When the user stops the suction, the switching slider 70 moves forward by the elastic force of the elastic member 80 and returns to the initial position. The communication hole 71 of the switching slider 70 is guided by the guide member 50, As shown in Fig.

When the dual type Neblae of the present invention generates a suction force through the mouthpiece 20, the switching slider 70 disposed immediately in front of the discharge port 21 moves backward, And the cathode electrode assembly 62 are electrically connected to each other to perform switching operation to supply power to the vaporization unit 40. The vaporized aerosol is supplied to the switching slider 70 and the anode electrode assembly 61, Passes through the cathode electrode member (62) and is discharged to the discharge port (21).

Therefore, the vaporizing unit 40 can be operated almost simultaneously with the suction of the user, so that the vaporized aerosol can be sucked, so that a sufficient amount of the aerosol can be sucked even with a weak suction force. Particularly, it is possible to select either one of the two kinds of drugs (A, B) by selecting switch 90 or to select both kinds of drugs and suck it in an aerosol form.

[0040] The medicament contained in the cartridge 41 of the vaporization unit 40 will be described in detail as follows.

The above-mentioned medicines are used for preventing inhalation lung disease after smoking, which comprises as an active ingredient, a mixed extract which is mainly composed of Zygomycetes, Angelica keiskei, Maekmoongdong, and Yabukamuni extract and which can further contain alfalfa, Bokyeong, Or a pharmaceutical composition for therapeutic use.

The composition may further comprise at least one extract selected from the group consisting of sweet potato, passerine, omija, gakyung, jawan, white peony, jujube, health, ginseng, ginseng, mint, safflower, And may further include additional.

The pharmaceutical composition of the present invention can be used as an active ingredient in a mixed extract comprising a mixture of Zaenchu, Janggui, Maekmundong, Yabuanmun, Sambuchei, Bepyeong, . In addition, it is also preferable to include a mixed extract as an active ingredient, which further comprises a herbal extract, a sesquicifier, a water extract, a watery extract, a brow, and an infertile extract.

The pharmaceutical composition preferably contains a mixed extract as an active ingredient, including a herbal extract, a veterinary medicine, a jujube, a health, a plant extract, a ginseng, a mint, and a safflower extract. It is also preferable to include a mixed extract further containing an anhydrous extract as an active ingredient.

It is also preferable that the pharmaceutical composition contains, as an active ingredient, a mixed extract obtained by mixing all of the above extracts.

The pharmaceutical composition may contain 5 to 12% by weight of each of the above-mentioned Zygomycetes, Angelica keiskei, Maekmoongdong, Yambuanmunum, Sangbokpyeon, Baekryeong, Chunmunmok, Gardenia and Golden extracts with respect to 100% by weight of the total composition.

The pharmaceutical composition uses a mixed extract of the natural extract. In particular, the composition contains Angelica keiskei keiskei and Makkumong dong, so that the composition has anticancer, antioxidant and anti-inflammatory effects.

In addition, the pharmaceutical composition may be prepared by (i) liquefying the vapor generated by vaporizing the mixed extracts including Zygomycorrhizae, Angelica keiskei, Maekmoongdong, Yabanmunum, Albaephyphi, Bokyeong, ; And (ii) mixing the distillation extract with soy wax to solidify the composition or mix it with agarooligos to gel the composition.

In one embodiment, the method of solidifying or gelling is not limited as long as it is by methods used in the art, but it is preferable to solidify or gellify using soy wax or agarooligos.

The extract of the above pharmaceutical composition may be obtained by extracting and isolating from nature using an extraction and separation method known in the art. The 'extract' defined in the present invention is extracted using an appropriate solvent, For example, hot water extract, polar solvent-soluble extract or non-polar solvent-soluble extract.

As the solvent, any solvent acceptable in the art may be used, and water or an organic solvent may be used. Examples of the solvent include purified water, methanol, ethanol, propanol, isopropanol, butanol, butylene glycol, acetone, ether, Various solvents such as benzene, chloroform, ethyl acetate, methylene chloride, hexane, and cyclohexane may be used alone or in combination. However, It does not.

As the extraction method, any one of the methods such as hot water extraction method, cold extraction method, reflux cooling extraction method, solvent extraction method, steam distillation method, ultrasonic extraction method, elution method and compression method can be selected and used. In addition, the desired extract may be further subjected to a conventional fractionation process or may be purified using a conventional purification method.

The resulting extract can be obtained in the form of a liquid in which impurities are removed by filtration or centrifugation according to a conventional method, or the obtained liquid form extract can be obtained in powder form by concentration under reduced pressure and / or drying in accordance with a conventional method.

The pharmaceutical composition may be administered orally (e.g., by ingestion or inhalation) or parenterally (e.g., by injection, sedation, implantation, suppository), and the injection may be by intravenous, , Intramuscular injection or intraperitoneal injection. The pharmaceutical composition may be formulated into tablets, capsules, granules, fine subtilae, powders, sublingual tablets, suppositories, ointments, injections, emulsions, suspensions, syrups, . The various forms of the above pharmaceutical compositions may be prepared by known techniques using pharmaceutically acceptable carriers customarily used in each formulation. Examples of pharmaceutically acceptable carriers are excipients such as excipients, binders, disintegrating agents, lubricants, preservatives, antioxidants, isotonic agents, buffers, encapsulating agents, sweeteners, solubilizers, bases, , Suspending agents, stabilizers, coloring agents and the like.

Although the pharmaceutical composition varies depending on the form of the pharmaceutical, it contains about 0.01 to 95% by weight of the extract or the compound of the present invention.

The specific dosage of the pharmaceutical composition may vary depending on the kind of mammal including the person to be treated, body weight, sex, degree of disease, judgment of a doctor, and the like. Preferably, 0.01 to 50 mg of active ingredient per kilogram of body weight per day is administered per day for oral administration, and 0.01 to 10 mg of active ingredient per kilogram of body weight per day for parenteral administration. The total daily dose may be administered once or several times depending on the severity of the disease, the judgment of the physician, and the like.

Hereinafter, the pharmaceutical composition used for the production of the medicament will be described in more detail.

Example 1: Preparation of mixed extract

The mixed extract according to the present invention is prepared by distillation of distillation of the extract and cooling the steam resulting from the vaporization of the mixed extract once more. Accordingly, it is characterized by being able to prevent or alleviate pulmonary disease without side effects because it contains a natural component beneficial to the human body as an effective ingredient.

In addition, due to the use of distillation liquid, the smell of herbal medicine can be suppressed, so that the user can easily access to weak noodles, and the color can be treated transparently to prevent pigmentation.

The mixed extract distillate was prepared as follows.

1) We prepared 10 kinds of dried medicinal materials consisting of 9 kinds of dried medicinal materials, each of which consisted of Ganjanggwa, Angelica, Maekmundong,

2) This medicinal material was pulverized by a pulverizer and pulverized.

3) Mixed powders of 9 kinds of medicinal materials were placed in a sieve cloth to prevent the powder from being precipitated in the extract.

4) Put the crepe containing mixed powder into the hot water extractor well and put 1L of water. And then subjected to hot water extraction at a temperature of 100 ° C or higher for 2 to 3 hours.

5) After the hot water extraction, the extract was filtered using a filter paper.

6) The filtered extract of the precipitate was put into a distillation apparatus to distill the distilled mixture.

7) The mixed extracts were stored in a refrigerator.

Example 2: Preparation of solid composition comprising mixed extract

The distillate of the mixed extract prepared in Example 1 was gelated by the following method.

1) The distilled mixture of mixed extracts was stored at room temperature for a certain time.

2) Agar was added to 1 L of water so as to have a weight ratio of 10%, powder was added and boiled.

3) The solution in which agar and powder were melted was kept at a temperature of 50 to 60 ° C to prevent gelation.

4) The distillation solution left at room temperature was put into a stirrer and the stirrer was operated. The temperature of the stirrer was maintained at 50 to 60 ° C.

5) The agarooligosaccharide solution was added at 3% of the weight of the distillate.

6) The distillate and agarooligos were mixed well and injected into a solidification mold.

7) After 2 hours, when the mixture solution was cooled, the gel was collected, packed and stored.

The distillate of the mixed extract prepared in Example 1 was solidified by the following method.

1) The distillate stored in the refrigerator was allowed to stand at room temperature for a certain time.

2) Soy wax was put into a stirrer maintained at 60 to 70 ° C, and operated to dissolve.

3) The distillate was put in 9% by weight of soya wax.

4) Mix well with a stirrer and pour into a solidification mold to make a shape.

5) After 16 ~ 24 hours, the solidified distillate was removed from the frame and packaged.

Experimental Example 1: Identification of toxicity and side effects

30 adult rats were orally administered for 90 days at a dose ratio (i.e., a dose of 1.5-2 ml per 1 kg of body weight) of the mixed extract distillate prepared in Example 1 to human, Daily conditions were observed for days. As a result, no abnormality was found in the anatomical findings as well as the apparent physiological abnormalities in all experimental groups.

Experimental Example 2: Nicotine-induced inhibition of lung cytotoxicity

First, the distilled solution of the mixed extract prepared in Example 1 was lyophilized and diluted to a concentration of 500 μg / ml in PBS buffer solution. Nicotine was also purchased and diluted to 500 and 1000 μg / ml, respectively, in the same manner. Then, the mixed extracts were treated with MRC-9 normal lung cells frequently used in lung cell experiments, and after 2 hours, the nicotine dilutions were treated by concentration. Then, lung cells were cultured in a 5% CO ₂ incubator at 37 ° C for 24 hours, and the viability of the cells was measured by MTT assay.

The MTT assay method is as follows. The MTT reagent is treated with MTT reagent and after 4 hours, the living cells form a purple formazan. The formazan is collected and dissolved in DMSO. The absorbance is measured at 540 nm using ELISA (enzyme-linked immunosorbent assay) Respectively.

As a result, cell viability was reduced by 25.8% and 6.7%, respectively, compared with the cells treated with 1000 and 500 μg / ml of nicotine dilution. However, the cell survival rate of the pretreated mixed extract distillate according to the present invention increased in a dose dependent manner. Therefore, it was found that the extract of the present invention is very effective in preventing and suppressing nicotine-induced lung cytotoxicity.

EXPERIMENTAL EXAMPLE 3: Inhibition of lung cytotoxicity by pharmaceutical composition

10 g of tobacco (Marlboro medium, Philip Morris) were mixed with 100 ml of nutrient medium and stored at 37 ° C for 2 hours. The mixture was then centrifuged at 450 ㅧ g for 10 minutes, and the supernatant was collected again at 13,000 ㅧ g And centrifuged for 2 hours. The supernatant was separated from the resultant, adjusted to pH 7.4 with 5N NaOH, and then sterilized to prepare an aseptic tobacco extract using a 0.22 μm microfilter.

In the same manner as described above, 100 μg / ml of the mixed extract according to Example 1 was treated with lung cells and after 2 hours, all of the nutrient medium was removed, and the tobacco extract was diluted 1/4 with nutrient medium. Respectively. Then, the mixed extract distillate according to Example 1 was treated again with the same concentration. After 48 hours, MTT assay was performed to measure cell viability. The results are shown in Table 1 below.

division Cell Viability (%) Cells that did not do anything 100.0 Tobacco extract 1/4 diluted cells 23.2 The cells pretreated with the extract of Example 1 33.7

As a result of the measurement, the cell group treated with the tobacco extract diluted had a low cell viability of 23.2%, but the cell group treated with the mixed extract distillate of the present invention showed a higher cell viability than the cell group treated with the tobacco extract Respectively.

Thus, it has been confirmed that the composition containing the mixed extract according to the present invention can prevent and inhibit lung cytotoxicity by various kinds of compounds contained in tobacco. Accordingly, it was found that by inhaling air through the composition according to the present invention after smoking, it is very effective in preventing or alleviating lung disease caused by smoking.

While the present invention has been particularly shown and described with reference to exemplary embodiments thereof, it will be understood by those skilled in the art that various changes and modifications may be made without departing from the spirit and scope of the present invention as defined by the appended claims. And it is to be understood that such modified embodiments belong to the scope of protection of the present invention defined by the appended claims.

10: main body 20: mouthpiece
21: Discharge port 30: Power supply unit
31: battery 32: controller
40: vaporizing unit 41: cartridge
42: aerosol generating unit 43:
44a: first fiber body 44b: second fiber body
45a: first ultrasonic vibrator 45b: second ultrasonic vibrator
50: guide member 51: vent hole
55: flow guide 61: anode electrode body
62: cathode electrode body 63, 64: wire
70: switching slider 71: communication hole
72: Through hole 73: Switching terminal
80: elastic member 90: selection switch

Claims (6)

A hollow cylindrical main body;
A mouthpiece installed at a rear end of the main body and having a discharge port for discharging vaporized aerosol in the main body;
A power supply unit installed inside the main body;
A vaporization unit for aerosolizing the medicament by a power source applied by the power supply unit;
A tubular guide member formed to communicate with the discharge port in front of the discharge port and having a through hole through which the aerosol can flow;
An anode electrode member and a cathode electrode member made of a conductive material and electrically connected to the power supply unit on an inner surface of the guide member;
The air electrode assembly is slidable in the front-rear direction on the inside of the guide member, moves backward by an air suction force generated through the discharge port, and contacts the anode electrode assembly and the cathode electrode assembly while electrically connecting the anode assembly and the cathode assembly A communication hole communicating with the ventilation hole when the ventilation hole is moved backward by a suction force is formed so as to pass through the side surface and air and aerosol passing through the ventilation hole communicating with the ventilation hole are passed through the center of the rear end toward the outlet of the mouthpiece And a tubular switching slider having a through hole formed therein,
The power supply unit is turned on or off by contact or separation between the switching slider and the anode electrode body and the cathode electrode body so as to supply or cut off power to the vaporization unit,
The vaporization unit comprises a cartridge having a first chamber and a second chamber which are formed in parallel by intermediate partition walls to accommodate two different types of medicaments, and a cartridge which is formed to communicate with one end of the cartridge and has aerosol An aerosol generating unit that is formed so that a plurality of exhaust ports are formed so as to pass therethrough; and a first fiber body that is disposed between the cartridge and the aerosol generating unit and supplies the medicines contained in the first chamber and the second chamber to the aerosol generating unit, And a second ultrasonic vibrator that is electrically connected to the controller of the power supply unit to ultrasonically vibrate the medicine supplied into the aerosol generating unit along the first fibrous body and the second fibrous body, Lt; / RTI >
Further comprising a selection switch for selecting either one of the first ultrasonic vibrator and the second ultrasonic vibrator to operate or both to selectively generate an aerosol from either or both of the two types of medicines contained in the cartridge So that it can be sucked. The method according to claim 1,
Further comprising an elastic member for resiliently supporting the switching slider so that the switching slider returns to the initial position when the suction force through the discharge port is removed. The method according to claim 1,
Wherein the anode electrode member and the cathode electrode member are provided so as to protrude radially inwardly of the guide member. The method according to claim 1,
Wherein the switching slider is made entirely of a conductive metal. The method according to claim 1,
The switching slider is made of a resin material and has a ring shape in which a through hole through which air and an aerosol pass is formed at the center of the switching slider and a switching terminal made of a conductive metal to be in contact with the anode electrode body and the cathode electrode body is attached And a second type nibbler. The pharmaceutical composition according to claim 1,
Liquorice, Angelica, Maekmundong Wherein the composition comprises a mixed extract as an active ingredient and a composition comprising at least one extract selected from the group consisting of alfalfa, bamboo, astragalus, gourd, and gold.

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