KR101808024B1 - Tablet comprising powder of Tenebrio molitor larva and manufacturing Method for preparing the same - Google Patents

Abstract

The present invention relates to tablets containing brown larch larvae powder and a method for producing the same, and it is an object of the present invention to provide a tablet containing brown larch larvae powder, It is easy to consume brown goats, and patients who need health improvement due to inflammation related diseases or cancer are able to easily ingest useless ingredients of brown goats.

Description

[0001] The present invention relates to tablets containing brown larvae larvae and methods for preparing the same,

The present invention relates to tablets containing Tenebrio molitor larvae powder and a process for their preparation. More particularly, the present invention relates to tablets containing larval larvae having a strength that is easy to pack and handle, easy to take and carry, as well as easy to store and high in preference, and a method for producing the same.

The brown duck ( Tenebrio molitor ) is dark brown and about 15mm long. Adults usually lay eggs in grains. The eggs hatch after 1 to 2 weeks, and the hatched larvae are called mealworm. Brown goat larvae are 9 to 20 times molt, become pupae, become alienated (adult), are nocturnal, and distributed throughout the world. The brown goat larvae contain 50 to 55% protein and 17 amino acids (Yu et al., Journal of the Korean Society of Food Science and Nutrition 42 (2); 249, 2013). Among them, glycine, alanine, In the present study, we investigated the effects of arginine on growth hormone synthesis in children and the improvement of blood circulation in adults by using serine (Lee et al., Korea Food Research Society, 31, 802, 1999) Is contained in a large amount. In addition, brown larvae contain large amounts of crude fat (30-35%) and contain many unsaturated fatty acids, 75-80% of total fatty acids. Therefore, brown larvae with abundant proteins and unsaturated fatty acids are highly valuable as health food materials as well as food materials.

As a conventional technique for brown larvae, Korean Patent Laid-Open Publication No. 10-2015-0050712 discloses a composition for anti-cancer comprising an extract of brown gruel or fractions thereof as an active ingredient, Korean Patent No. 10-1424125, A composition for the treatment of inflammatory diseases including larva, and Korean Patent No. 10-1404566 disclose compositions for the prevention or treatment of dementia including brown gurr extract, respectively, and thus it is possible to develop a food having various functions using brown gurr as a raw material .

However, when the larvae of brown goat larvae are foodstuffs themselves, there is a feeling of discomfort due to the dislike of insects, and it is inconvenient to take and carry the correct dose. Therefore, the development of various processed products using insects as raw materials is urgently required to promote consumption of insects considered as future food resources.

Among the processed products, tablets are made by compressing granules into a small disc shape, and they are usually made into granules by adding contents or excipients, binders or lubricants, and molding them using a compressor. Tablets are easy to carry and easy to take, and tablets made with gelatin can be used for correction of odor, odor and irritation. In addition, it is expected that more kinds of refined foods will be required for modern people who are busy living because they have the advantage that they are accurate in dosage and can prevent deterioration and contamination by appropriate packaging and maintain quality for a long period of time. Tablets require a certain degree of mechanical strength to prevent breakage and wear during manufacture, sale and use. In addition, tablets having maximized active ingredient content while minimizing the amount of additives used for molding and hardness are economically advantageous as well as convenient for taking. The hardness of the tablet and the content of the active ingredient may be influenced by the appearance of the tablet, the manufacturing process, and the type and amount of additives used for binding purposes.

With reference to the prior art for the additive of tablets, Korean Patent Laid-Open No. 10-2005-0118775 discloses that particles containing a physiologically active substance are coated with a mixture of crystalline saccharides (A) and amorphous saccharides (B) Which is mixed with a granule made of a saccharide to be tableted and aged to have a high hardness unchanged in the porous structure, Korean Patent Laid-Open No. 10-2001-0006835 discloses a tablet in which spray-dried mannitol, co- Preparation of tablets containing crospovidone as a co-disintegrant and one or more pharmaceutically acceptable additives, Korean Patent Laid-Open No. 10-2007-0074878 discloses tablets prepared by dry granulation using pregelatinized starch The preparation method, Korean Patent Registration No. 10-1062747, discloses a process for producing red ginseng concentrate granules with increased color and fluidity, Korean Patent Laid-Open No. 10-2011-0119148 Korean Patent No. 10-1196959 discloses a method for producing silkworm powder, and Korean Patent Publication No. 10-0695315 discloses a method for producing a purified product using garlic. However, The tablets containing the larvae larvae and the preparation method thereof have not yet been disclosed.

Accordingly, the inventors of the present invention have studied the various physiological activities of brown larvae, and confirmed that the tablets containing the brown larch larvae powder had the best qualities, thus completing the present invention.

Korean Patent Laid-Open No. 10-2015-0050712 (composition for anti-cancer comprising brown gruel extract or fractions thereof as an active ingredient, applicant: K.Korea, publication date: 2015.05.11) Korean Patent No. 10-1424125 (composition for the treatment of inflammatory diseases including brown goat larva, applicant: Korea, issue: Jul. 21, 2014) Korean Patent No. 10-1404566 (Composition for preventing or treating dementia including brown gruel extract, Applicant: Korea, Registered on May 31, 2014)

Yoo et al., Journal of the Korean Society of Food Science and Nutrition 42 (2): 249, 2013. Lee et al., Korean Food Science Society, 31, 802, 1999. Jo, et al., The Korean Journal of Food and Nutrition, 31, 935, 2011.

It is an object of the present invention to provide tablets containing brown larch larvae powder and a process for their preparation. More particularly, it is an object of the present invention to provide tablets containing larval larvae of easy-to-handle, easy-to-handle, easy-to-store, and high-preference browning, and a method for producing the same, .

The present invention relates to brown gill tablets containing 5-17% by weight of Tenebrio molitor larvae powder.

The tablets may contain at least one selected from the group consisting of fructooligosaccharides, xylitol, edible dry yeast, beer dry yeast, amino acid mixed product, selenized dry yeast, chrome dry yeast, mixed lactose powder, crystalline cellulose, silicon dioxide and purified glucose A lubricant may be included, including excipients and magnesium stearate.

Preferably 1 to 2.5% by weight of fructooligosaccharide, 0.5 to 1.8% by weight of xylitol, 15 to 40% by weight of edible dry yeast, 2 to 7% by weight of beer dry yeast, 0.1 to 10% 1 to 10% by weight of lactose, 0.1 to 1% by weight of selenized yeast, 0.1 to 0.5% by weight of chromium dry yeast, 3 to 13% by weight of mixed lactose powder, 10 to 23% by weight of crystalline cellulose, 0.5 to 2% To 25% by weight of an excipient and 0.5 to 2% by weight of magnesium stearate.

The brown goat larva powder contained in the tablet was obtained by fasting the brown larvae for 1 to 3 days to degrease the excrement so that the crude fat content was 15 to 25% and then pulverized to a particle size of 50 mesh or less Powder.

Accordingly, the present invention can provide a method for producing the tablet.

Preferably, the first step is to fasten the brown larvae for 1 to 3 days, degrease the excrement so that the crude fat content is 15 to 25%, and then pulverize to a particle size of 50 mesh or less;

A second step of mixing the brown gourd powder prepared in the first step with an excipient;

A third step of preparing granules mixed in the second step and drying the mixture; And

A fourth step of adding a lubricant to the granules dried in the third step and then tableting;

And a method for producing a tablet containing a brown larva.

The granule drying conditions in the second step may be 1 to 3 hours at 40 to 60 ° C.

In the above-described preparation method, 5 to 17% by weight of the larva of Brown mallow larvae based on 100% by weight of the tablet may be included. The tablets may further contain one or more selected from the group consisting of fructooligosaccharide, xylitol, edible dry yeast, beer dry yeast, amino acid mixed product, selenized dry yeast, chrome dry yeast, mixed lactose powder, crystalline cellulose, silicon dioxide, Such excipients may be included. Preferably 1 to 2.5% by weight of fructooligosaccharide, 0.5 to 1.8% by weight of xylitol, 15 to 40% by weight of edible dry yeast, 2 to 7% by weight of beer dry yeast, 0.1 to 10% 1 to 10% by weight of lactose, 0.1 to 1% by weight of selenized yeast, 0.1 to 0.5% by weight of chromium dry yeast, 3 to 13% by weight of mixed lactose powder, 10 to 23% by weight of crystalline cellulose, 0.5 to 2% To 25% by weight of the composition. The lubricant may include magnesium stearate, and preferably 0.5 to 2% by weight of magnesium stearate may be contained as the lubricant based on 100% by weight of the tablet.

Accordingly, the present invention provides a tablet containing brown larch larvae powder prepared by the above method.

Hereinafter, the present invention will be described in detail.

The present invention relates to a brown gruel tablet containing 5 to 17% by weight of brown gruel larva powder. Even if the brown gruel larva powder is contained in an amount of less than 5% by weight, there is no problem in tableting, For the purpose of the invention for ingestion, it is preferred that at least 5% by weight of brown larch larvae powder is included. On the other hand, if the larvae of brown mallow larvae exceed 17% by weight in the tablets, the tabletability may be impaired and the tablets may not be formed.

The tablets may contain at least one selected from the group consisting of fructooligosaccharides, xylitol, edible dry yeast, beer dry yeast, amino acid mixed product, selenized dry yeast, chrome dry yeast, mixed lactose powder, crystalline cellulose, silicon dioxide and purified glucose Excipients may be included. At this time, it is preferable that at least three or more kinds of excipients are contained, and more preferably, at least 6 kinds of excipients are included. Most preferably, the tablets contain 1 to 2.5% by weight of fructooligosaccharide, 0.5 to 1.8% by weight of xylitol, 15 to 40% by weight of edible dry yeast, 2 to 7% by weight of beer dry yeast, 0.1 to 10% 1 to 2% by weight of silicon dioxide, 0.1 to 1% by weight of selenium dry yeast, 0.1 to 0.5% by weight of chromium dry yeast, 3 to 13% by weight of mixed lactose powder, 10 to 23% by weight of crystalline cellulose, 10 to 25% by weight of an excipient may be contained. At this time, if the content of these excipients is out of the above range, the tableting property may be inhibited, and tablet formation may be difficult. The above excipients are used to minimize the imbalance and odor of the brown goat's larva larvae, to increase the preference of granules or tablets, to impart appropriate hardness and shape at the time of tablet formation, May be added for the purpose of making it easy to size. For example, as excipients for the formation and maintenance of the granules produced in the intermediate stage of tablet production, purified glucose, mixed lactose powder and crystalline cellulose may be used. These give effects such as flavor softening, moisture absorption prevention, discoloration prevention, bad smell removal, oxidation prevention and the like. Another yeast and amino acid mixture used as an excipient has a function of imparting more functionality having a medicinal component of brown goat larva, enhancing palatability, and imparting binding ability during tablet formation.

The brown goat larva powder contained in the tablet was obtained by fasting the brown larvae for 1 to 3 days to degrease the excrement so that the crude fat content was 15 to 25% and then pulverized to a particle size of 50 mesh or less Powder. Degreasing brown larvae can increase the rate of pure protein ingestion, but also prevent the deterioration of preservability due to the breakdown of the fat during long-term storage of the tablets. On the other hand, when the larvae of brown gourd larvae are larger than 50 mesh, the tableting qualities of the tablets are deteriorated and it may be difficult to form tablets.

In the method for preparing tablets of the present invention, the granules formed in the granule manufacturing process may be prepared by drying at 40 to 60 ° C for 1 to 3 hours to minimize the deformation of the protein in the brown gruel powder.

The dried granules may be mixed with a lubricant and formed into tablets in a tablet machine. As the lubricant used herein, a lubricant used in ordinary tablet forming may be used. In the present invention, magnesium stearate is preferably used have. At this time, magnesium stearate is preferably contained in an amount of 0.5 to 2% by weight based on 100% by weight of the tablet.

On the other hand, the tablet of the present invention can be provided as a pharmaceutical composition for preventing or treating various diseases or as a health functional food for preventing or improving these diseases.

When the tablet of the present invention is administered as a pharmaceutical composition or a health functional food, the dosage will vary depending on the age, sex, weight, and the specific disease or pathological condition, disease or pathological condition to be treated / The severity of the condition, the route of administration, and the judgment of the prescriber. The tablet may be administered once a day or divided into several doses. The dose is not intended to limit the scope of the invention in any way.

The present invention relates to tablets containing brown larch larvae powder and a method for producing the same, and it is an object of the present invention to provide a tablet containing brown larch larvae powder, It is easy to consume brown goats, and patients who need health improvement due to inflammation related diseases or cancer are able to easily ingest useless ingredients of brown goats.

1 is a graph showing the hardness of the tablets prepared in Examples 1 to 3 and Comparative Examples 3 and 5 of the present invention.
2 is a graph showing the degree of grinding of the tablets prepared in Examples 1 to 3 and Comparative Examples 3 and 5 of the present invention.
3 is a graph showing weight deviations of the tablets prepared in Examples 1 to 3 and Comparative Examples 3 and 5 of the present invention.

Hereinafter, preferred embodiments of the present invention will be described in detail. However, the present invention is not limited to the embodiments described herein but may be embodied in other forms. Rather, these embodiments are provided so that this disclosure will be thorough and complete, and will fully convey the concept of the invention to those skilled in the art.

≪ Examples 1 to 3 and Comparative Examples 1 to 5. Preparation of Tablets Containing Brown Dung Larvae Powder>

( Tenebrio molitor ) larvae were purchased from professional breeding farms and fasted for 2 days to dry out the excrements completely. After degreasing to 20% of crude fat content, a microplex impact mill (Model 50-ZPS, Alpine Aktiengesellschaft, Augsburg, Germany). Thereafter, the pulverized product was sieved with a 50 mesh sieve to obtain a powder having a particle size of 50 mesh or less. The powder was sealed in a polyethylene film and used as a sample while being kept frozen at -80 ° C .

Next, the brown gruel powder and the excipients required for various tablet formation were mixed in the weight% ratios shown in Table 1 below, granulated using a granulator, dried at 50 ° C for 2 hours, Magnesium stearate was added as a lubricant, and the mixture was placed in a tablet machine having an elliptical mold and molded to give a total weight of 1 g of tablets.

Constituent Content (% by weight) Example 1 Example 2 Example 3 Comparative Example 1 Comparative Example 2 Comparative Example 3 Comparative Example 4 Comparative Example 5 Brown ass
Larva powder 16.4 12 5 32 20 0 18 18 Isomalt 0 0 0 29 0 0 0 0 Fructooligosaccharide 2.4 One One 3 3 2 One 2.4 Xylitol 1.6 1.8 0.5 2 2 1.2 One 1.6 Edible dry yeast 19 36.7 37.4 21 28 27.9 38 22.9 Beer dry yeast 3 7 7 10 5 5 5 4 Amino acid mixture preparation 0.8 0.8 0.1 One One One 4 0.8 Selenium dry yeast 0.8 0.1 0.4 One One 0.5 0.5 0.8 Chromium dry yeast 0.4 0.1 0.1 0.5 0.5 0.4 0.5 0.4 Magnesium stearate One 0.5 2 0.5 1.5 0 2 1.5 Mixed lactose powder 10.6 3 13 0 13 20 0 10.6 Crystalline cellulose 20.5 10 23 0 25 15 15 20.5 Silicon dioxide 1.7 2 0.5 0 0 2 0 1.7 Refined glucose 21.8 25 10 0 0 25 15 14.8 total 100 100 100 100 100 100 100 100

< Experimental Example  One. Unparalleled , Appearance and hardness of tablets &gt;

The hardness was measured using a measuring machine known in the art, and the amount of the lost weight was calculated by rotating the test piece about 20 to 50 times and then weighing again. The results are shown in Table 2 below.

Condition Reference value Example 1 Example 2 Example 3 Comparative Example 1 Comparative Example 2 Comparative Example 3 Comparative Example 4 Comparative Example 5 Heart condition refine
formation refine
formation refine
formation refine
formation Tableting
Impossible Tableting
Impossible refine
formation Tableting
Impossible refine
formation Hardness (kg / cm ² ) 3.0 or higher 4.2 4.1 4.0 - - 4.5 - 2.0 Marson (%) 1.0 or less 0.4 0.5 0.4 - - 0.8 - 1.3 Capping
(The presence or absence) radish radish radish radish - - radish - U Weight deviation (%) 2.0 or less 0.5 0.6 0.4 - - 3.0 - 2.4 Using tablets
Possibility ○ ○ ○ ○ × × × × ×

In Table 2, each reference value is based on the standard values of the health functional foods, and ○ represents the case where the possibility of commercialization in the whole of the standard value, shape and all aspects of the refinement is satisfied, and X is the case where all the appearance and sub- And there is no possibility of a product.

It can be seen from Table 2 that tablets exhibiting a satisfactory state are formed only under the conditions of Examples 1 to 3 of the present invention. Compression was impossible under the conditions of Comparative Examples 1, 2 and 4, and Comparative Examples 3 and 5 , It is possible to find disadvantages such as the hardness, the degree of grinding, the weight deviation, etc., of the tablets as well as the disadvantages such as the breakage of the tablets while the tablets are stored, and the possibility as a product is very low. It can be confirmed that the tablets are formed well only when the content of the brown gruel powder and each excipient satisfies all the conditions of Examples 1 to 3.

In addition, the content of brown gourd contained in the tablets of Comparative Example 5 exceeded 17% by weight, but the weight range of each excipient was found to be in accordance with the conditions for preparing tablets of the present invention. Therefore, It can be seen that it is very important that the content is not exceeded. On the other hand, referring to the results of Comparative Example 5, it can be concluded that when the content of the brown gruel powder is small or not very much contained, the formation of the tablets is unconditionally well performed. However, when the components of the tablet composition of Comparative Example 3 were examined, it was confirmed that the brownish larval larva powder was not contained, magnesium stearate was not contained, and the mixed lactic acid powder was contained in excess of the range of the present invention. Therefore, it can be seen that not only the brown goat larvae powder but also the excipients for forming tablets of the present invention should be uniformly contained to facilitate tablet formation.

<Experimental Example 2: Sensory evaluation>

(9 points: best: 1 point: highest score: 1 point, highest score: 9 points). The sensory evaluation was performed on 10 sensory testees trained beforehand, The worst), and the results are shown in Table 3 below.

division Example 1 Example 2 Example 3 Comparative Example 5 incense 9.0 ± 0.2 9.1 ± 0.1 9.1 ± 0.2 7.0 ± 0.2 flavor 9.1 ± 0.2 9.2 ± 0.1 8.9 ± 0.1 7.5 ± 0.1 Overall likelihood 8.9 ± 0.1 9.0 ± 0.2 9.0 ± 0.1 7.3 ± 0.1

Referring to Table 3 above, it can be seen that the tablets of Examples 1 to 3 are also better in taste, flavor and overall acceptability than tablets of Comparative Example 5.

Claims (9)

Tenebrio molitor larvae were fasted for 1 to 3 days on the basis of 100% by weight of the tablets to degrease excrement so that the crude fat content was 15 to 25%, and then pulverized to a particle size of 50 mesh or less 5 to 17% by weight of a brown larvae larvae powder, 1 to 2.5% by weight of fructooligosaccharide, 0.5 to 1.8% by weight of xylitol, 15 to 40% by weight of edible dry yeast, 2 to 7% by weight of beer dry yeast, 0.1 to 1 Wherein the selenized yeast is present in an amount of 0.1 to 1 wt%, the chromium dry yeast is 0.1 to 0.5 wt%, the mixed lactose powder is 3 to 13 wt%, the crystalline cellulose is 10 to 23 wt%, the silicon dioxide is 0.5 to 2 wt% 25% by weight and magnesium stearate 0.5-2% by weight. delete delete Tenebrio molitor larvae were fasted for 1 to 3 days to degrease the excrement so that the crude fat content was 15 to 25% and then pulverized to a particle size of 50 mesh or less to prepare powder ;
A second step of preparing a mixture of the larvae of Brown mallow and the excipient prepared in the first step;
A third step of preparing granules mixed in the second step and drying the mixture; And
A fourth step of adding magnesium stearate to the granules dried in the third step and then tableting;
&Lt; RTI ID = 0.0 &gt; 1, &lt; / RTI &gt;
Based on 100% by weight of the tablet, the brownish larval larvae powder contained 5 to 17% by weight,
The excipient includes 1 to 2.5 wt% of fructooligosaccharide, 0.5 to 1.8 wt% of xylitol, 15 to 40 wt% of edible dry yeast, 2 to 7 wt% of beer dry yeast, 0.1 to 1 wt% of mixed amino acid preparation, 0.1 to 1 wt% of chromium dry yeast, 0.1 to 0.5 wt% of chromium dry yeast, 3 to 13 wt% of mixed lactose powder, 10 to 23 wt% of crystalline cellulose, 0.5 to 2 wt% of silicon dioxide and 10 to 25 wt% of purified glucose ,
Wherein the magnesium stearate is contained in an amount of 0.5 to 2% by weight. 5. The method of claim 4,
Wherein the granule is dried at 40 to 60 ° C for 1 to 3 hours in the second step. delete delete delete 6. A brown gill purifier prepared by the method of claim 4 or 5.

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