KR101677460B1 - 알레르기성이 감소된 수용성 로열젤리를 포함하는 피부 미백 및 노화방지용 화장료 조성물 - Google Patents
알레르기성이 감소된 수용성 로열젤리를 포함하는 피부 미백 및 노화방지용 화장료 조성물 Download PDFInfo
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- KR101677460B1 KR101677460B1 KR1020140064469A KR20140064469A KR101677460B1 KR 101677460 B1 KR101677460 B1 KR 101677460B1 KR 1020140064469 A KR1020140064469 A KR 1020140064469A KR 20140064469 A KR20140064469 A KR 20140064469A KR 101677460 B1 KR101677460 B1 KR 101677460B1
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- allergen
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Abstract
Description
도 2는 본 발명의 구체예에 따른 로열젤리의 알레르기 유발 단백질이 제거된 것을 확인한 젤 사진이다(위: 생 로열젤리; 아래: 본 발명의 로열젤리) (산지; A: 안성; C: 철원; J: 진주).
도 3은 본 발명의 구체예에 따른 알레르기성이 감소된 수용성 로열젤리의 세포독성을 평가한 그래프이다(RJ: 동결건조 로열젤리; WSRJ: 본 발명의 알레르기성이 감소된 수용성 로열젤리).
도 4는 본 발명의 구체예에 따라, 알레르기성이 감소된 수용성 로열젤리와 일반 로열젤리의 멜라닌 생성 억제 효과를 확인한 도이다(A:로열젤리 처리에 따른 B16F1세포에서의 멜라닌 생성 억제 정도를 나타낸 사진; B: 로열젤리 처리에 따른 멜라닌 함량; -: 무처리군; +: 처리군; 1: 1 ug/ml 농도의 본 발명의 로열젤리 처리군; 10: 10 ug/ml 농도의 본 발명의 로열젤리 처리군)
도 5는 본 발명의 구체예에 따라, 알레르기성이 감소된 수용성 로열젤리와 일반 동결건조 로열젤리의 티로시나아제(A), TRP-1(B), TRP-2(C) mRNA 발현 억제효과를 비교한 도이다.
도 6은 본 발명의 구체예에 따라, 알레르기성이 감소된 수용성 로열젤리와 일반 동결건조 로열젤리의 티로시나아제(A), TRP-1(B), TRP-2(C) 단백질 발현 억제효과를 비교한 도이다.
분석항목 (%) | 생로열젤리 | 본 발명 |
10-HDA | 1.95±0.02 | 4.1±0.06 |
Claims (8)
- 40 내지 60kDa 의 알레르기 유발 단백질이 제거된 수용성 로열젤리를 포함하는 피부 미백 및 노화방지용 화장료 조성물로서,
상기 수용성 로열젤리는 동결건조된 생로열젤리 분말의 에탄올 추출물을 동결건조한 뒤 분말화하여 증류수에 용해한 후, 수산화나트륨으로 중성화하여 pH 7 내지 8로 조절한 중성화 용액의 동결건조분말이고,
상기 동결건조된 생로열젤리 분말의 에탄올 추출에 의해 로열젤리의 비수용성 부분이 제거되고, 그리고
상기 중성화에 의해 40 내지 60kDa 의 알레르기 유발 단백질이 제거되는 것을 특징으로 하는 피부 미백 및 노화방지용 화장료 조성물.
- 삭제
- 제1항에 있어서, 상기 수용성 로열젤리는 10-HDA 함량이 4.1% 이상인 것을 특징으로 하는 피부 미백 및 노화방지용 화장료 조성물.
- 삭제
- 삭제
- 삭제
- 제1항에 있어서, 상기 수용성 로열젤리는 조성물 총 중량에 대하여 0.001 내지 90 중량%로 함유되는 것을 특징으로 하는 피부 미백 및 노화방지용 화장료 조성물.
- 제1항에 있어서, 상기 화장료 조성물은 TRP-1, TRP-2, 티로시나아제 활성 저해능 및 멜라닌 생성 저해능을 갖는 것을 특징으로 하는 피부 미백 및 노화방지용 화장료 조성물.
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