KR101650741B1 - Coating film-forming agent for teeth whitening and Forming method of teeth whitening-coating film - Google Patents

Abstract

The present invention relates to a coating film forming agent for dental bleaching and a method for forming a dental bleaching coating film on teeth using the same. The coating film forming agent for dental bleaching provides user convenience due to short duration required for dry, and the dental bleaching coating film formed on teeth exhibits excellent durability and chemical resistance as well, thereby keeping the dental bleaching coating film last for a long time. In addition, added with functions of preventing tooth sensitivity and dental caries, it is possible to provide a functional coating film forming agent for dental bleaching.

Description

TECHNICAL FIELD [0001] The present invention relates to a tooth whitening agent for tooth whitening and a method for forming teeth whitening coating film,

The present invention relates to a coating film forming agent for tooth whitening and a method for forming a tooth whitening coating film on teeth using the same.

As recent living standards have improved, there has been an increasing need to improve the tone and morphology of teeth as the aesthetic demands on the teeth increase.

The teeth consist of an inner layer of dentin and a hard outer layer of enamel which is a tooth protection layer. The enamel layer of the tooth is essentially opaque white or slightly grayish white. It is this enamel layer that becomes dirty or discolored.

Many materials that people face or touch daily cause tooth whitening to become dim or dirty, especially food, tobacco and beverage products that people consume tend to stain teeth. These products or materials tend to accumulate in the enamel layer of the tooth, forming a thin film on the tooth surface. Such stains and discolouration-causing substances can penetrate the enamel layer, and this problem gradually develops over many years, causing a significant discoloration of the enamel layer.

The discoloration of teeth can be divided into endogenous discoloration and extrinsic discoloration. Exogenous discoloration is caused by adherence of coloring matter to the outside of the tooth and can be easily removed by mechanical manipulation. However, endogenous discoloration is caused by the pathological condition of dental pulp But it is possible that decomposition products due to hemorrhage in the dimension or destruction of the dental tissue infiltrate into the dental tubule. The most common treatment for endogenous discoloration of teeth is tooth whitening using hydrogen peroxide. Such tooth whitening is performed by in-office bleaching, home bleaching, and over the counter bleaching according to the use of whitening agents. Can be distinguished.

Generally, although the whitening mechanism of hydrogen peroxide is not fully understood, it is thought that free whitening occurs by free radicals generated from hydrogen peroxide through the enamel and dentin of the tooth to oxidize the pigment present in the tooth . In the 1970s, light and heat devices have been used to activate the decomposition reaction of hydrogen peroxide to enhance the whitening effect and shorten the time required for whitening. However, the technique of using light and heat together raises the temperature of the teeth and enlarges the blood vessels in the dimension, causing post-operative hypersensitivity, resulting in poor stability. In addition, the conventional tooth whitening agent has to use light and / or heat, which results in a problem that convenience is greatly reduced. Various kinds of self-whitening agents such as patches and gels have been developed and marketed, but disadvantages have arisen. For example, the whitening patch is easy to use but has a slow reaction effect, and the gel type self-whitening agent is late in drying and inconvenient to use a tray.

Korean Unexamined Patent Publication No. 2004-0028710 (Publication date 2004.04.03.) Korean Patent Publication No. 2014-0104529 (Publication date 2014.08.29)

As a result of various studies for a long period of time, the present inventor has developed a coating film forming agent for tooth whitening which shortens the drying time of tooth whitening, maintains the holding time for a long time, and has the effect of preventing sickness and tooth decay. That is, the present invention provides a coating film forming agent for tooth whitening and a method for forming a tooth whitening coating film on teeth using the same.

In order to solve the above-mentioned problems, the coating film forming agent for teeth whitening of the present invention comprises a water-soluble polymer, a tooth whitening agent and a stabilizer; And a detergent comprising a water-insoluble polymer, a whitening component activator or a whitening component decomposition accelerator and a solvent.

Another object of the present invention is to provide a method for forming a tooth whitening coating on a tooth, comprising the steps of: applying a composition of the coating film forming agent for teeth whitening to a tooth to form a coating layer; And two steps of coating the two surfaces of the first coating layer on one surface of the first coating layer to form a second coating layer; And the like.

The method for forming a tooth whitening coating film of the present invention may further comprise the steps of: 1) preparing a mixture by mixing the 1-part and the 2-part of the coating film forming agent for teeth whitening; And a second step of applying the mixture to teeth to form a coating film.

The coating film forming agent for tooth whitening of the present invention is excellent in ease of use because of its high drying time and is excellent in the durability and chemical resistance of the tooth whitening coating film formed on the teeth and not only the tooth whitening coating film lasts for a long time, May be added to provide a coating film forming agent for a functional tooth whitening.

Hereinafter, the coating film forming agent for tooth whitening of the present invention will be described in more detail.

The coating film-forming agent for tooth whitening of the present invention comprises a one-component gel comprising a water-soluble polymer, a tooth whitening agent and a stabilizer; And a two-gel gel comprising a water-insoluble polymer, a whitening component activator or a whitening component decomposition promoting agent and a solvent.

The coating film forming agent for tooth whitening of the present invention can form a coating film for tooth whitening on teeth by two methods. One of the methods is to apply the one-gel of the coating film forming agent for tooth whitening to teeth, A first step of forming a coating film; And a second step of coating a surface of the first coating layer with the second coating layer of the first coating layer to form a second coating layer, thereby forming a coating layer for teeth whitening on the teeth.

The second method comprises a first step of preparing a mixture by mixing the first gel and the second gel of the coating film forming agent for teeth whitening; And applying the mixture to a tooth to form a film; and then performing a second step of forming a coating film for teeth whitening on the teeth.

The mixture may contain the 1-gel and the 2-gel at a weight ratio of 1: 0.5 to 3, preferably 1: 0.8 to 2, more preferably 1: 0.8 to 1.4, At this time, if the mixing amount of the two-gel is less than 0.5 weight ratio, the whitening component of one tooth does not act sufficiently, and the dental whitening effect is decreased or the durability of the whitening coating film is decreased. If the mixing amount of the two gel-forming gels is more than 3 parts by weight, there may be a problem that the tooth whitening component of one tooth acts excessively and abruptly on the tooth, thereby damaging the teeth and / or the gums.

In the coating film forming agent for tooth whitening of the present invention, each of the first and second agents is of the gel type.

The water-soluble polymer of the first gel-forming gel may be at least one selected from the group consisting of polyvinylpyrrolidone, polyvinyl alcohol, hydroxymethylcellulose, hydroxypropylcellulose, hydroxyethylcellulose, methylcellulose and poloxamer , And may preferably include one or more selected from the group consisting of polyvinylpyrrolidone, polyvinyl alcohol, and hydroxymethylcellulose.

In addition, the tooth whitening agent among the above-mentioned one-component gel ingredients may contain, as a whitening component, end species or two or more species selected from peroxides, phosphates, silane compounds, chlorine bleaches and percarbonates, preferably hydrogen peroxide, And may include end species or two or more species selected from carbamide peroxide, tetrasodium pyrophosphate peroxideate, and calcium peroxide. The tooth whitening agent may be used in an amount of 20 to 50 parts by weight, preferably 25 to 45 parts by weight, more preferably 30 to 42 parts by weight, based on 100 parts by weight of the water-soluble polymer, If the amount is less than 20 parts by weight, the amount of the used toothpaste may be too small to exhibit a sufficient tooth whitening effect. If the amount of the used amount exceeds 50 parts by weight, the amount of the used toothpaste may be too large to injure the teeth and / or the gums. It is good to use.

In addition, the stabilizing agent among the above-mentioned ingredients serves to prevent the tooth whitening agent component from lowering its activity in the distribution process, and it is preferable to use a stabilizer such as sodium stannate, sodium acid pyrophosphate, sodium pyrophosphate, sodium metaphosphate, Sodium polyphosphate, sodium polyphosphate, ethylenediamine tetraacetate and potassium pyrophosphate, or a mixture of two or more selected from the group consisting of sodium stannate, sodium acid pyrophosphate and sodium pyrophosphate, or 2 It is recommended to mix more than species. The amount of the stabilizer to be used may be 20 to 50 parts by weight, preferably 20 to 45 parts by weight, more preferably 25 to 42 parts by weight, based on 100 parts by weight of the water-soluble polymer, If the amount is less than 20 parts by weight, the amount of the tooth whitening agent is too small and the period of circulation is long, the tooth whitening agent may be denatured to deteriorate the tooth whitening effect. If the amount is more than 50 parts by weight, There is a problem that it does not work, so it is better to use it within the above range.

The first agent may be prepared by mixing the water-soluble polymer, tooth whitening agent, and stabilizer with a water-soluble solvent, and preferably purified water may be used as a water-soluble solvent. The amount of the water-soluble solvent to be used may be 400 to 700 parts by weight, preferably 450 to 650 parts by weight, more preferably 500 to 630 parts by weight based on 100 parts by weight of the water-soluble polymer.

The second gel component of the coating film forming agent for tooth whitening of the present invention promotes the oxidation reaction of the one tooth whitening agent and enhances the durability of the whitening coating film to secure long term stability.

2 The water-insoluble polymer of the gel component is used for securing long-term stability by increasing the durability of the whitening coating film. The water-insoluble polymer is selected from the group consisting of shellac, rosin, zein, Eudragit ), Ethyl cellulose, and polyacrylic acid, or two or more types selected from the group consisting of shellac, udragit and ethyl cellulose, or a mixture of two or more thereof.

The whitening component activator or the whitening component decomposition accelerator of the two gelatinous components serves to promote the oxidation reaction of the tooth whitening agent among the one gelatinous component and is preferably a divalent iron or metal component catalyst, May include end species or two or more species selected from among iron sulconate, iron fumarate, iron chloride, iron sulphate, and ferrous sulphate, more preferably one selected from the group consisting of iron gluconate, iron fumarate and iron chloride, It is good to use. The amount of the whitening component activator or whitening component decomposition accelerator to be used is 15 to 35 parts by weight, preferably 20 to 32 parts by weight, more preferably 22 to 30 parts by weight, based on 100 parts by weight of the water-insoluble polymer If the amount of the whitening component activator or the whitening component degradation promoting agent is less than 15 parts by weight, the amount of the whitening component activator or the whitening component decomposition promoting agent may be too small and the whitening effect may be deteriorated. If the amount is more than 35 parts by weight, The teeth whitening component of the teeth may suddenly react to injure the teeth and / or the gums. Therefore, it is preferable to use within the above range.

In addition, the solvent of the two components may be a mixture of two or more species selected from water and ethanol to shorten the drying time of the gel-type 1-gel and the 2-gel. The solvent may be used in an amount of 300 to 450 parts by weight, preferably 350 to 420 parts by weight, based on 100 parts by weight of the water-insoluble polymer. When the amount of the solvent is less than 300 parts by weight, the drying time is fast, There may be a problem that the drying is delayed if it is used in excess of 450 parts by weight.

In addition, the two-gel composition may further contain additives in addition to the water-insoluble polymer, the whitening component activator or the whitening component decomposition accelerator, and the solvent. The additive may include at least one selected from pigments, dentifrice prevention agents, and prophylactic agents.

Among the additives, the above-mentioned pigments may be those generally used in the related art. Preferably, the pigment may be a mixture of two or more species selected from among titanium oxide, silicon dioxide and titanated mica. When the pigment is used, the amount of the pigment to be used may be 0.1 to 10 parts by weight, preferably 0.5 to 8 parts by weight, based on 100 parts by weight of the water-insoluble polymer. If the amount of the pigment is less than 0.1 part by weight, The effect due to the use of the pigment may not be seen. If the pigment is used in an amount exceeding 10 parts by weight, there may be a problem of feeling a foreign body feeling.

Among the additives, the dentifrice preventive may be any of those generally used in the art, and may preferably include one or more selected from the group consisting of sodium fluorophosphate, sodium fluoride, fluorocarbons and fluorinated amines. The amount of the dental caries prevention agent may be 0.5 to 5 parts by weight, preferably 2 to 4.5 parts by weight, based on 100 parts by weight of the water-insoluble polymer. If the dental caries prevention agent is used in an amount less than 0.5 parts by weight, It may not be possible to exhibit an additional effect of preventing tooth decay. If it is used in excess of 5 parts by weight, there may be a problem of causing side effects such as tooth coloring and fluorosis.

In addition, among the additives, the above-mentioned silylation inhibitor may be any of the conventional ones used in the art, and preferably includes at least one selected from the group consisting of ascorbic acid, potassium nitrate, tocopherol acetate, allantoin, hydroxyapatite and coenzyme Q10 can do. The amount of the silane inhibitor may be 3 to 10 parts by weight, preferably 3 to 8 parts by weight, based on 100 parts by weight of the water-insoluble polymer. If the amount of the silane inhibitor is less than 3 parts by weight, Is too small to prevent the additional effect of syringes. If the syringe is used in excess of 10 parts by weight, various side effects may be caused.

Hereinafter, the present invention will be described in more detail with reference to examples. However, the scope of the present invention is not limited by the following examples.

[Example]

Example 1: Preparation of a coating film forming agent for tooth whitening

(1) Manufacture of one

100 parts by weight of polyvinyl alcohol, 38.5 parts by weight of hydrogen peroxide, 38.5 parts by weight of sodium stannate and 592 parts by weight of purified water were mixed to prepare a gel type agent.

(2) Manufacture of two products

25 parts by weight of iron fumarate, 250 parts by weight of ethanol, and 125 parts by weight of purified water were mixed with 100 parts by weight of shellac to prepare a gel type binary agent.

(3) Next, the 1-part and the 2-part were mixed at a weight ratio of 1: 1 to prepare a coating film-forming agent for tooth whitening.

Example 2

1 and 2 were prepared in the same manner as in Example 1 except that 0.76 part by weight of sodium fluorophosphate was added to 100 parts by weight of shellac at the time of preparing 2, thereby preparing a gel type binary agent.

Next, the 1-part and 2-part were mixed at a weight ratio of 1: 1 to prepare a coating film-forming agent for tooth whitening.

Example 3

1 and 2 were prepared in the same manner as in Example 1 except that 1.0 part by weight of potassium nitrate was added to 100 parts by weight of the 2 parts by weight to prepare a gel type binary agent.

Next, the 1-part and 2-part were mixed at a weight ratio of 1: 1 to prepare a coating film-forming agent for tooth whitening.

Example 4

1 and 2 were prepared in the same manner as in Example 1, and a coating film forming agent for tooth whitening having the composition shown in Table 1 below was prepared.

Comparative Example 1

100 parts by weight of polyvinyl alcohol, 38.5 parts by weight of hydrogen peroxide, 38.5 parts by weight of sodium stannate and 592 parts by weight of purified water were mixed to prepare a gel-type tooth whitening coating film-forming agent.

Comparative Examples 2 to 4

1 and 2 were prepared in the same manner as in Example 1, except that a coating film forming agent for tooth whitening having the composition shown in Table 1 below was prepared and each of Comparative Examples 2 to 4 was carried out.

[Table 1]

Experimental Example: Experiment to measure whitening effect

The whitening effect measurement experiment was carried out using a new sample and a coating film forming agent for tooth whitening which produced the existing whitening gel.

In the experiment, each of the tooth whitening coating film forming agents was applied to a coffee sheet in an amount of 0.02 g / cm < ² >, and after 1 hour, the degree of discoloration of the coffee color was measured. The measurement results are shown in Table 3 below.

[Table 2]

[Table 3]

The results of the measurement of the fading degree shown in Table 3 show that the fading degrees of Examples 1 to 4 are excellent. However, in the case of Comparative Example 1 in which a binary agent was not used and Comparative Example 4 in which hydrogen peroxide was used in an amount of less than 20 parts by weight, the degree of discoloration of the coffee color was insignificant. In the case of Comparative Example 2 in which the whitening component activator was used in an amount less than 15 parts by weight, the degree of fading of the coffee was relatively decreased as compared with the Example. In addition, in Comparative Example 3 using 40 parts by weight of the whitening component activator in an amount exceeding 35 parts by weight, the fading degree showed the best result, but there was a side effect that the tooth whitening component of the one was abruptly reacted to injure the teeth .

Through the above experimental example, it was confirmed that the coating film forming agent for tooth whitening of the present invention had excellent whitening effect, and was excellent in ease of use and long-term stability.

Claims (15)

A gelatin gel comprising 20 to 50 parts by weight of a tooth whitening agent and 20 to 50 parts by weight of a stabilizer, based on 100 parts by weight of the water-soluble polymer; And
A two-part gel comprising 15 to 35 parts by weight of a whitening component activator or a whitening component decomposition accelerator and 300 to 450 parts by weight of a solvent, based on 100 parts by weight of the water-insoluble polymer,
The water-soluble polymer includes at least one selected from the group consisting of polyvinylpyrrolidone, polyvinyl alcohol, hydroxymethylcellulose, hydroxypropylcellulose, hydroxyethylcellulose, methylcellulose, and poloxamer,
Wherein the water-insoluble polymer comprises at least one member selected from the group consisting of shellac, rosin, zein, Eudragit and ethyl cellulose,
Wherein the solvent of the two-gel gel comprises at least one selected from water and ethanol. The agent for forming a whitening film for teeth whitening according to claim 1, wherein the dyed gel further comprises at least one selected from the group consisting of a pigment, a dentifrice preventing agent and a prophylactic agent. delete delete The method according to claim 2,
Wherein the composition further comprises at least one selected from the group consisting of 0.1 to 10 parts by weight of the pigment, 0.5 to 5 parts by weight of a dentifrice preventive, and 3 to 10 parts by weight of a prophylactic agent, based on 100 parts by weight of the water-insoluble polymer. Forming agent. delete The tooth whitener of claim 1, wherein the tooth whitening agent comprises at least one of a peroxide, a phosphate, a silane compound, a chlorine bleach, and a percarbonate,
The stabilizer may be at least one selected from the group consisting of sodium stannate, sodium pyrophosphate, sodium pyrophosphate, sodium metaphosphate, sodium polyphosphate, sodium acid polyphosphate, ethylenediamine tetraacetate and potassium pyrophosphate Wherein the composition is a coating film forming agent for whitening teeth. The tooth whitener of claim 7, wherein the tooth whitening agent is at least one selected from the group consisting of hydrogen peroxide, carbamide peroxide, tetrasodium pyrophosphate peroxideate, and calcium peroxide. A coating film forming agent for whitening teeth. delete The tooth whitening coating film according to claim 1, wherein the two whitening component activators or whitening component decomposition accelerators comprise at least one member selected from the group consisting of iron gluconate, iron fumarate, iron chloride, iron sulfate and ferrous sulfate. Forming agent. 3. The method of claim 2,
Wherein the pigment includes at least one selected from titanium oxide, silicon dioxide, and titanated mica,
Wherein the dental caries preventive agent comprises at least one selected from the group consisting of sodium fluorophosphate, sodium fluoride, fluorocarbons and fluorinated amines,
Wherein the prophylactic agent comprises at least one selected from the group consisting of ascorbic acid, potassium nitrate, tocopherol acetate, allantoin, hydroxyapatite and coenzyme Q10. The agent for forming a whitening film for teeth whitening according to claim 1, which comprises a mixture of the first gelatin and the second gelatin in a weight ratio of 1: 0.5-3. A method for forming a tooth whitening coating layer on a tooth,
A step of applying the agent of claim 1 to a tooth to form a coated film; And
A second step of coating the second agent of claim 1 on one surface of the first coating film to form a second coating film;
Wherein the tooth whitening coating layer is formed on the teeth. A method for producing a mixture according to claim 1, wherein the mixture is prepared by mixing the first agent and the second agent. And
Applying the mixture to a tooth to form a coating film;
Wherein a tooth whitening coating film is formed on the teeth. 15. The method of claim 14, wherein the mixture of step 1 comprises 1: 0.5 to 3: 1 by weight of the first agent and the second agent.