KR101482318B1 - Apparatus for Magnetic field therapy for preventing and treating leukosis - Google Patents

Abstract

The present invention includes a main power supply device, a full bridge circuit for switching the direction of a current applied to a coil inside the circuit, and a control element circuit for inputting a control signal to the full bridge circuit, wherein a magnetic field generated by the coil A magnetic field of a frequency of 800 Hz to 2,000 Hz and a magnetic field of 10 to 100 Gauss intensity is applied to a human body. The magnetic therapy apparatus is characterized by applying a magnetic field of a specific frequency and a specific intensity to kill a leukemia cancer cell, It is possible to prevent or treat leukemia by inhibiting proliferation of cancer cells.

Description

[0001] Apparatus for preventing and treating leukemia [

The present invention includes a main power supply device, a full bridge circuit for switching the direction of a current applied to a coil inside the circuit, and a control element circuit for inputting a control signal to the full bridge circuit, wherein a magnetic field generated by the coil And a magnetic field of 800 Hz to 2,000 Hz is applied to the human body.

Since the 1970s, the magnetic field has been stimulated by the human body and has been used to treat bones, nerves, and muscle disorders. Especially, when a strong pulse magnetic field is applied to the human body, the conductivity is very low, but induction currents are generated to stimulate muscles and nerve cells.

Pulsed magnetic field stimulation Therapy therapy has been studied for many diseases. Magnetic field treatment effects have been reported for various diseases such as bones, joints, spinal fixation, ulcers, pelvic pain, nervous system disorders, neuroendocrine system, stroke, coronary artery, cancer and psychophysiological diseases. However, when the results described in these papers are analyzed, the target disease is varied, and cell and animal experiments are also studied by various types, and the results are reported as a mixture of positive and negative effects. This is because the excitation conditions that apply the magnetic field have been applied so widely that the shape of the waveform is very complicated and various conditions are used by the experimenter such as pulse or sine wave and burst pulse, In addition to not being systematically selected in a very wide range from Hz to GHz, it has been difficult to compare and analyze the results of the experiments by testing the magnetic field strength from μTesla to several Tesla and also the magnetic field change dB / dt. In other words, it was difficult to obtain consistent research results.

Induction of Apoptosis in Human Leukemic Cells by Magnetic Fields (1997.06.) Revealed that nucleosome-size DNA fragmentation in human myelogenous leukemic cell lines when exposed to 50Hz electromagnetic fields And it is shown that cell death of myeloid leukemia cells is induced by the application of 50Hz electromagnetic field. Therapeutic electromagnetic field effects on angiogenesis and tumor growth (2001.11.) Showed that tumor growth was significantly reduced when therapeutic electromagnetic fields (TEMF) were applied (treatment conditions: 0, 10, 15, Min) is disclosed.

U.S. Patent No. 5,842,966 discloses a technique for treating arthritis using square-wave magnetic field signals of 20 Gauss or less at a frequency of 1 to 30 Hz, and U.S. Patent No. 5,935,054 discloses a technique for stimulating the sensory nerve to control excitement or seizure And using a weak pulsed magnetic field signal of 1/2 Hz, 50 nT, which can produce the same effect as shaking and sleeping babies for rest and sleep, U.S. Patent No. 6,162,166 Discloses a technique for treating a pain and a tinnitus (ringing) phenomenon with a pulse-type magnetic field signal of 1 to 3 Gauss at 20 Hz or less and acting as a sedative to calm the excitement.

Listed above is an example of treating a specific disease using a specific frequency in a low frequency region. US Patent No. 6,675, 047 discloses a method for treating a specific disease in 0.1 Hz to 10 Hz at 0.01 Hz intervals, In particular, U.S. Patent No. 5,480,373 discloses a method of treating a low frequency of 200 Hz, 20 Hz, and 3 Hz, which is a mechanical vibration frequency of a blood vessel, by frequency modulation Discloses a therapeutic effect on various diseases caused by the human body including arthritis, osteoporosis, diabetes, Parkinson's disease,

Korean Laid-Open Patent Application No. 2001-0095888 applies a high magnetic field of 1 to 10 T intensity to induce an eddy current of 0.1 to 50 mA in the human body. This pulse is one or two pulses whose pulse signal is within 100 μsec, (Transcranial Magnetic Brain Stimulation) method for obtaining an effect of treatment by imparting an impulse. However, when a high magnetic field is applied for a long period of time of several seconds or longer, there is a problem that it may cause damage to normal cell tissue. In this case, It is preferable to limit the strength of the magnetic field by a repetitive transcranial magnetic brain stimulation (rTMS) method which can continuously use the pulse train for a long time.

However, it has been reported that when an alternating magnetic field is applied, the proliferation of cancer cells is rather induced. Thus, there is a lack of specific and reliable reporting on the extent to which certain types of magnetic fields can actually be treated through magnetic field application.

On the other hand, our body bones maintain the shape of the body, allow exercise, play a role in the regulation of calcium, and there are bone marrow tissues in the inside of the bones which are less dense than the bones. Here, white blood cells, red blood cells, platelets Of blood cells. Leukemia is a cancer of the white blood cells among these blood cells, and abnormal white blood cells (leukemia cells) are excessively proliferated and the production of normal white blood cells, red blood cells and platelets is suppressed. Decrease in normal white blood cell count can cause immunity deterioration resulting in sepsis due to bacterial infection. Reduction of red blood cells leads to anemia (dizziness, headache, dyspnea), and platelet reduction causes bleeding tendency. In addition, hyperplastic leukemia cells themselves can cause high fever, fatigue, bone pain, diarrhea, unconsciousness, dyspnea, and bleeding tendency. When a leukemia patient is untreated, life threatens to be caused by these symptoms. Therefore, there is a need to develop a treatment method and treatment apparatus capable of effectively killing leukemia cells or inhibiting proliferation of leukemia cells, while having relatively few side effects as compared with conventional chemotherapy methods.

As described above, leukemia can cause immune degradation and sepsis due to excessive proliferation of abnormal leukocytes (leukemia cells), and life threatens due to these symptoms when not treated. However, But also caused various side effects. Therefore, there is a need for a therapeutic method and treatment apparatus for treating leukemia cells, which is non-invasive, relatively less adverse, and capable of effectively killing leukemia cells or inhibiting proliferation of leukemia cells.

The present invention includes a main power supply device, a full bridge circuit for switching the direction of a current applied to a coil inside the circuit, and a control element circuit for inputting a control signal to the full bridge circuit, A non-invasive method of killing leukemic cells or inhibiting the proliferation of leukemic cells using a magnetic therapy apparatus configured to apply a magnetic field of a frequency of 800 Hz to 2,000 Hz and a magnetic field of 10 to 100 Gauss intensity to the human body, Can effectively prevent or treat leukemia.

The present invention has the effect of preventing or treating leukemia by killing leukemic cancer cells by inhibiting the proliferation of leukemic cancer cells by applying a magnetic field of a certain frequency and specific intensity.

In the present invention, it is possible to prevent or treat leukemia non-invasively by using a magnetic field. The magnetic field can stimulate the deep part even if it does not come in direct contact, and the penetration effect is better than the electric stimulation and the pain or discomfort caused by the electric stimulation There is an advantage that there is no.

Further, the use of the magnetic therapy apparatus according to the present invention has the advantage that the side effects are less than the existing leukemia treatment methods.

1 shows the case where the magnetic field is not applied to the cell line RBL-2H3 (control group), and the right drawing shows the case where the cell is applied for 24 hours at a magnetic field of 2000 Hz and 50 G at 100 magnification.
2 shows the case where the magnetic field is not applied to the cell line RBL-2H3 (control group), and the right drawing shows the case where the magnetic field is applied at a frequency of 1000 Hz and 50 G for 24 hours at 100 magnification.
On the left side of FIG. 3, the cell line RBL-2H3 shows a case where the magnetic field is not applied (control group), and the right side shows the case of application of the magnetic field of 500 Hz and 50 G for 24 hours.
FIG. 4 shows the results of measurement of the proliferation rate (72 hours) for each frequency of the RBL-2H3 cell line.
5 is a block diagram showing a magnetic therapy apparatus according to an embodiment of the present invention.
6 is a block diagram schematically showing the configuration of the voltage generator.
Figure 7 illustrates an exemplary full bridge circuit.
Figure 8 shows another exemplary full bridge circuit.
Fig. 9 shows generation of a control signal with a parallax in the control element circuit.
10 is a diagram illustrating an exemplary combination of a main power supply and a DC / DC converter.
11 shows an exemplary central processing circuit of a control element circuit.
12 is a diagram showing a push full output for operation of a full bridge circuit.
13 is a diagram showing the flow direction of the current in the full bridge circuit.

The present invention relates to a magnetic therapy apparatus capable of preventing or treating leukemia by inhibiting the proliferation of leukemic cancer cells or killing leukemia cancer cells by applying a magnetic field of a specific frequency and intensity.

Hereinafter, the present invention will be described in more detail.

The present invention includes a main power supply device, a full bridge circuit for switching the direction of a current applied to a coil inside the circuit, and a control element circuit for inputting a control signal to the full bridge circuit, wherein a magnetic field generated by the coil A magnetic field of a frequency of 800 Hz to 2,000 Hz and a magnetic field of 10 to 100 Gauss intensity is applied to the human body.

In one embodiment of the invention, the magnetic field may be in the range of 1,000 Hz to 1,500 Hz, 10 to 100 Gauss, more specifically 1,000 Hz to 1,400 Hz, 10 to 100 Gauss, more specifically about 1,200 Hz, 10 to 100 Gauss intensity.

In one embodiment of the invention, the magnetic field has a magnetic field of 800 Hz to 2,000 Hz, 30 to 70 Gauss, 1,000 to 1,500 Hz, 30 to 70 Gauss, more specifically 1,000 Hz to 1,400 Hz, 30 to 70 Gauss, , And may be 30 to 70 Gauss intensity.

In one embodiment of the present invention, the magnetic field is in the range of 800 Hz to 2,000 Hz, 40 to 60 Gauss, 1,000 Hz to 1,500 Hz, 40 to 60 Gauss more specifically 1,000 Hz to 1,400 Hz, 40 to 60 Gauss, And may be 40 to 60 Gauss intensity.

In one embodiment of the invention, the magnetic field has a magnetic field of 800 Hz to 2,000 Hz, about 50 Gauss, 1,000 Hz to 1,500 Hz, about 50 Gauss, more specifically 1,000 Hz to 1,400 Hz, about 50 Gauss, more specifically about 1,200 Hz, It can be century.

When the magnetic field strength in the above range is applied, leukemia cancer cell death or leukemia cancer cell proliferation inhibition effect is most remarkable.

In one embodiment of the invention, the magnetic field is at least 0.5 hour, in particular at least 1 hour, more particularly at least 6 hours, more particularly at least 12 hours, even more specifically at least 24 hours, even more specifically at least 72 hours However, the present invention is not limited thereto, and can be appropriately adjusted according to the therapeutic range and condition of the subject to be treated.

A magnetic therapy apparatus according to the present invention includes: a main power supply device for supplying power; A full bridge circuit for switching a direction of a current applied to a coil inside a circuit; And a control element circuit for inputting a control signal relating to the direction of the current applied to the coil and the magnitude of the power source so as to control the intensity of the magnetic field generated in the coils of the full bridge circuit.

In one embodiment of the present invention, the main power supply apparatus can supply DC power.

In one embodiment of the present invention, the magnetic treatment apparatus may further include a DC / DC converter for changing the size of the DC power generated in the main power supply apparatus.

In one embodiment of the present invention, the control element circuit may comprise a setting input switch for manually varying the frequency and the output voltage.

In one embodiment of the present invention, the control element circuit can generate signal pairs that are inverted in phase to control the direction of the current applied to the coil.

In one embodiment of the present invention, the full bridge circuit can be operated using a push full output that allows current to be supplied to the coil only when signal pairs with inverted phases are simultaneously active have.

In one embodiment of the present invention, the control element circuit can generate a signal with a parallax.

The configuration of the magnetic therapy apparatus of the present invention may be as follows, but the present invention is not limited thereto, and various modifications are possible.

The magnetic therapy apparatus 100 according to the present invention includes a wireless communication unit 110, an audio / video (A / V) input unit 120, a user input unit 130, a sensing unit 140, an output unit 150, 160, an interface unit 170, a control unit 180, a battery 190, and a magnetic therapy voltage generator 200. The components shown in Fig. 5 are not essential, so that a magnetic therapy apparatus having more or less components than those shown in Fig. 5 may be implemented.

Hereinafter, the components will be described in order.

The wireless communication unit 110 may include one or more modules that enable wireless communication between the magnetic therapy apparatus 100 and the wireless communication system or between the magnetic therapy apparatus 100 and the network in which the magnetic therapy apparatus 100 is located . For example, the wireless communication unit 110 may include a broadcast receiving module 111, a mobile communication module 112, a wireless Internet module 113, a short range communication module 114, and a location information module 115 .

The broadcast receiving module 111 receives broadcast signals and / or broadcast-related information from an external broadcast management server through a broadcast channel.

The broadcast channel may include a satellite channel and a terrestrial channel. The broadcast management server may be a server for generating and transmitting broadcast signals and / or broadcast-related information, or a server for receiving broadcast signals and / or broadcast-related information generated in advance and transmitting the broadcast signals and / or broadcast-related information to the magnetic therapy apparatus. The broadcast signal may include a TV broadcast signal, a radio broadcast signal, a data broadcast signal, and a broadcast signal in which a data broadcast signal is combined with a TV broadcast signal or a radio broadcast signal.

The broadcast-related information may refer to a broadcast channel, a broadcast program, or information related to a broadcast service provider. The broadcast-related information may also be provided through a mobile communication network. In this case, it may be received by the mobile communication module 112.

The broadcast-related information may exist in various forms. For example, an EPG (Electronic Program Guide) of DMB (Digital Multimedia Broadcasting) or an ESG (Electronic Service Guide) of Digital Video Broadcast-Handheld (DVB-H).

For example, the broadcast receiving module 111 may be a Digital Multimedia Broadcasting-Terrestrial (DMB-T), a Digital Multimedia Broadcasting-Satellite (DMB-S), a Media Forward Link Only A digital broadcasting system such as DVB-CB, OMA-BCAST, or Integrated Services Digital Broadcast-Terrestrial (ISDB-T). Of course, the broadcast receiving module 111 may be adapted to other broadcasting systems as well as the digital broadcasting system described above.

The broadcast signal and / or broadcast related information received through the broadcast receiving module 111 may be stored in the memory 160.

The mobile communication module 112 transmits and receives radio signals to at least one of a base station, an external terminal, and a server on a mobile communication network. The wireless signal may include various types of data depending on a voice call signal, a video call signal or a text / multimedia message transmission / reception. The mobile communication module 112 connects the communication with the 3D web providing server 700 under the control of the controller 180 and transmits a signal requesting the 3D web page selected by the user to the 3D web providing server 700. [ (700), and receives a signal including the 3D web page according to the request from the 3D web providing server (700).

The wireless Internet module 113 is a module for wireless Internet access, and may be built in or enclosed in the magnetic therapy apparatus 100. The wireless Internet module 113 connects the communication with the 3D web providing server 700 under the control of the controller 180 and transmits a signal requesting the 3D web page selected by the user to the 3D web providing server 700. [ (700), and receives a signal including the 3D web page according to the request from the 3D web providing server (700). WLAN (Wi-Fi), Wibro (Wireless broadband), Wimax (World Interoperability for Microwave Access), HSDPA (High Speed Downlink Packet Access) and the like can be used as the technology of the wireless Internet.

The short-range communication module 114 refers to a module for short-range communication. In accordance with the control of the control unit 180, the short-range communication module 114 connects a communication with the 3D web providing server 700 and transmits a signal requesting the provision of the 3D web page selected by the user to the 3D web providing server 700. [ (700), and receives a signal including the 3D web page according to the request from the 3D web providing server (700). Bluetooth, Radio Frequency Identification (RFID), Infrared Data Association (IrDA), Ultra Wideband (UWB), ZigBee, and the like can be used as the short range communication technology.

The position information module 115 is a module for acquiring the position of the magnetic therapy apparatus 100, and a representative example thereof is a Global Position System (GPS) module. According to the current technology, the GPS module 115 calculates distance information and accurate time information from three or more satellites, and then applies trigonometry to the calculated information to obtain a three-dimensional string of latitude, longitude, The location information can be accurately calculated. At present, a method of calculating position and time information using three satellites and correcting an error of the calculated position and time information using another satellite is widely used. In addition, the GPS module 115 can calculate speed information by continuously calculating the current position in real time.

5, an A / V (Audio / Video) input unit 120 is for inputting an audio signal or a video signal, and may include a camera 121 and a microphone 122. The camera 121 processes image frames such as still images or moving images obtained by the image sensor in the video communication mode or the photographing mode. The processed image frame can be displayed on the display unit 151. [

The image frame processed by the camera 121 may be stored in the memory 160 or transmitted to the outside through the wireless communication unit 110. [

At this time, two or more cameras 121 may be provided depending on the use environment.

For example, the camera 121 may include first and second cameras 121a and 121b for 3D imaging on the opposite side of the display unit 151 of the magnetic therapy apparatus 100, A third camera 121c for self-photographing the user may be provided in a part of the surface of the surface of the display unit 151 of the magnetic therapy apparatus 100. [

In this case, the first camera 121a is for capturing the left eye image, which is the source image of the 3D image, and the second camera 121b, for the right eye image capturing.

The microphone 122 receives an external sound signal through a microphone in a communication mode, a recording mode, a voice recognition mode, or the like, and processes it as electrical voice data. The processed voice data can be converted into a form that can be transmitted to the mobile communication base station through the mobile communication module 112 when the voice data is in the call mode, and output. Various noise reduction algorithms may be implemented in the microphone 122 to remove noise generated in receiving an external sound signal.

The user input unit 130 generates input data for controlling the operation of the magnetic therapy apparatus by a user.

The user input unit 130 may receive from the user a signal designating two or more contents among the displayed contents according to the present invention. A signal for designating two or more contents may be received via the touch input, or may be received via the hard key and soft key input.

The user input unit 130 may receive an input from the user for selecting the one or more contents. In addition, an input may be received from the user to generate an icon associated with a function that the magnetic therapy apparatus 100 can perform.

The user input unit 130 may include a directional keypad, a keypad, a dome switch, a touchpad (static / static), a jog wheel, a jog switch, and the like.

The sensing unit 140 senses the position of the magnetic therapy apparatus 100 such as the open / closed state of the magnetic therapy apparatus 100, the position of the magnetic therapy apparatus 100, the user's contact, the orientation of the magnetic therapy apparatus, And generates a sensing signal for controlling the operation of the magnetic therapy apparatus 100. [ It is also possible to sense whether the battery 190 is powered on, whether the interface unit 170 is connected to an external device, and the like. Meanwhile, the sensing unit 140 may include a proximity sensor 141. The proximity sensor 141 will be described later in relation to the touch screen.

The output unit 150 is for generating an output relating to visual, auditory or tactile sense and includes a display unit 151, an acoustic output module 152, an alarm unit 153, a haptic module 154, 155, and the like.

The display unit 151 displays (outputs) information to be processed by the magnetic therapy apparatus 100. For example, when the magnetic therapy apparatus is in the call mode, a UI (User Interface) or a GUI (Graphic User Interface) associated with a call is displayed. When the magnetic therapy apparatus 100 is in the video communication mode or the photographing mode, the photographed and / or received image or UI and GUI are displayed.

In addition, the display unit 151 according to the present invention supports 2D and 3D display modes.

That is, the display unit 151 according to the present invention may have a configuration in which the switch liquid crystal 151b is combined with a general display device 151a. By using the switch liquid crystal 151b, the optical parallax barrier 50 can be operated to control the traveling direction of the light so that different lights can be separated from the left and right eyes. Therefore, when a combined image of the right eye image and the left eye image is displayed on the display device 151a, the user can see the image corresponding to each eye and feel as if it is displayed in three-dimensional form.

That is, under the control of the control unit 180, the display unit 151 drives only the display device 151a without driving the switch liquid crystal 151b and the optical parallax barrier 50 in the 2D display mode Performs normal 2D display operation.

The display unit 151 drives the switch liquid crystal 151b and the optical parallax barrier 50 and the display device 151a under the control of the controller 180 to display the display liquid crystal 151b, 151a to perform the 3D display operation.

The display unit 151 may be a liquid crystal display (LCD), a thin film transistor-liquid crystal display (TFT LCD), an organic light-emitting diode (OLED) A flexible display, and a three-dimensional display (3D display).

Some of these displays may be transparent or light transmissive so that they can be seen through. This can be referred to as a transparent display, and a typical example of the transparent display is TOLED (Transparent OLED) and the like. The rear structure of the display unit 151 may also be of a light transmission type. With this structure, the user can see an object located behind the body of the magnetic therapy apparatus through the area occupied by the display unit 151 of the magnetic therapy apparatus body.

According to the embodiment of the magnetic therapy apparatus 100, there may be two or more display units 151. FIG. For example, in the magnetic therapy apparatus 100, the plurality of display portions may be spaced apart from one another or may be disposed integrally with each other, or may be disposed on different surfaces.

(Hereinafter, referred to as a 'touch screen') in which a display unit 151 and a sensor for sensing a touch operation (hereinafter, referred to as 'touch sensor') form a mutual layer structure, It can also be used as an input device. The touch sensor may have the form of, for example, a touch film, a touch sheet, a touch pad, or the like.

The touch sensor may be configured to convert a change in a pressure applied to a specific portion of the display unit 151 or a capacitance generated in a specific portion of the display unit 151 into an electrical input signal. The touch sensor can be configured to detect not only the position and area to be touched but also the pressure at the time of touch.

If there is a touch input to the touch sensor, the corresponding signal (s) is sent to the touch controller (not shown). The touch controller processes the signal (s) and transmits the corresponding data to the controller 180. Thus, the control unit 180 can know which area of the display unit 151 is touched or the like.

The proximity sensor 141 may be disposed within an interior region of the self-therapy device that is wrapped by the touch screen or near the touch screen. The proximity sensor refers to a sensor that detects the presence or absence of an object approaching a predetermined detection surface or a nearby object without mechanical contact using the force of an electromagnetic field or infrared rays. The proximity sensor has a longer life span than the contact sensor and its utilization is also high.

Examples of the proximity sensor include a transmission type photoelectric sensor, a direct reflection type photoelectric sensor, a mirror reflection type photoelectric sensor, a high frequency oscillation type proximity sensor, a capacitive proximity sensor, a magnetic proximity sensor, and an infrared proximity sensor. And to detect the proximity of the pointer by the change of the electric field along the proximity of the pointer when the touch screen is electrostatic. In this case, the touch screen (touch sensor) may be classified as a proximity sensor.

Hereinafter, for convenience of explanation, the act of recognizing that the pointer is positioned on the touch screen while the pointer is not in contact with the touch screen is referred to as "proximity touch & The act of actually touching the pointer on the screen is called "contact touch. &Quot; The position where the pointer is proximately touched on the touch screen means a position where the pointer is vertically corresponding to the touch screen when the pointer is touched.

The proximity sensor detects a proximity touch and a proximity touch pattern (e.g., a proximity touch distance, a proximity touch direction, a proximity touch speed, a proximity touch time, a proximity touch position, a proximity touch movement state, and the like). Information corresponding to the detected proximity touch operation and the proximity touch pattern may be output on the touch screen.

The audio output module 152 may output audio data received from the wireless communication unit 110 or stored in the memory 160 in a call signal reception mode, a call mode or a recording mode, a voice recognition mode, a broadcast reception mode, The sound output module 152 also outputs sound signals associated with functions (e.g., call signal reception tones, message reception tones, etc.) performed in the magnetic therapy apparatus 100. The audio output module 152 may include a receiver, a speaker, a buzzer, and the like.

The alarm unit 153 outputs a signal for notifying the occurrence of an event of the magnetic therapy apparatus 100. Examples of events that occur in a magnetic therapy device include receiving a call signal, receiving a message, inputting a key signal, and touch input. The alarm unit 153 may output a signal for notifying the occurrence of an event in a form other than the video signal or the audio signal, for example, vibration. In this case, the display unit 151 and the audio output module 152 may be a type of the alarm unit 153. The display unit 151 and the audio output module 152 may be connected to the display unit 151 or the audio output module 152, .

The haptic module 154 generates various tactile effects that the user can feel. A typical example of the haptic effect generated by the haptic module 154 is vibration. The intensity and pattern of the vibration generated by the hit module 154 can be controlled. For example, different vibrations may be synthesized and output or sequentially output.

In addition to the vibration, the haptic module 154 may include a pin arrangement vertically moving with respect to the contact skin surface, a spraying force or suction force of the air through the injection port or the suction port, a touch on the skin surface, contact with an electrode, And various tactile effects such as an effect of reproducing a cold sensation using an endothermic or exothermic element can be generated.

The haptic module 154 can be implemented not only to transmit the tactile effect through the direct contact but also to allow the user to feel the tactile effect through the muscular sensation of the finger or arm. At least two haptic modules 154 may be provided according to the configuration of the magnetic therapy apparatus 100.

The projector module 155 is a component for performing an image project function by using the magnetic therapy apparatus 100. The projector module 155 includes an image displayed on the display unit 151 in accordance with a control signal of the controller 180, Images that are the same or at least partially different can be displayed on an external screen or on a wall.

Specifically, the projector module 155 includes a light source (not shown) that generates light (for example, laser light) for outputting an image to the outside, a light source And a lens (not shown) for enlarging and outputting the image at a predetermined focal distance to the outside. Further, the projector module 155 may include a device (not shown) capable of mechanically moving the lens or the entire module to adjust the image projection direction.

The projector module 155 can be divided into a CRT (Cathode Ray Tube) module, an LCD (Liquid Crystal Display) module and a DLP (Digital Light Processing) module according to the type of the display means. In particular, the DLP module may be advantageous for miniaturization of the projector module 151 by enlarging and projecting an image generated by reflecting light generated from a light source on a DMD (Digital Micromirror Device) chip.

Specifically, the projector module 155 may be provided on the side surface, the front surface, or the back surface of the magnetic therapy apparatus 100 in the longitudinal direction. Of course, it is needless to say that the projector module 155 can be provided at any position of the magnetic therapy apparatus 100, if necessary.

The memory 160 may store a program for processing and controlling the controller 180 and may store the input / output data (e.g., a telephone directory, a message, an audio, a still image, an electronic book, History, and the like). The memory 160 may also store the frequency of use of each of the data (for example, each telephone number, each message, and frequency of use for each multimedia). In addition, the memory unit 160 may store data on vibration and sound of various patterns output when the touch is input on the touch screen.

The memory 160 also stores a web browser displaying 3D or 2D web pages in accordance with the present invention. The web browser can be downloaded from the 3D web providing server 700 via the wireless communication unit 110 and stored.

The memory 160 may be a flash memory type, a hard disk type, a multimedia card micro type, a card type memory (for example, SD or XD memory, etc.) ), A random access memory (RAM), a static random access memory (SRAM), a read-only memory (ROM), an electrically erasable programmable read-only memory (EEPROM), a programmable read- A magnetic disk, an optical disk, a memory, a magnetic disk, or an optical disk. The magnetic therapy apparatus 100 may operate in association with a web storage that performs a storage function of the memory 160 on the Internet.

The interface unit 170 serves as a path for communication with all external devices connected to the magnetic therapy apparatus 100. The interface unit 170 receives data from an external device or supplies power to each component in the magnetic therapy apparatus 100 or allows data in the magnetic therapy apparatus 100 to be transmitted to an external apparatus. For example, a wired / wireless headset port, an external charger port, a wired / wireless data port, a memory card port, a port for connecting a device having an identification module, an audio I / O port, A video input / output (I / O) port, an earphone port, and the like may be included in the interface unit 170.

The identification module is a chip for storing various information for authenticating the use right of the magnetic therapy apparatus 100. The identification module includes a user identification module (UIM), a subscriber identity module (SIM) (Universal Subscriber Identity Module, USIM), and the like. Devices with identification modules (hereinafter referred to as "identification devices") can be manufactured in a smart card format. Therefore, the identification device can be connected to the magnetic therapy apparatus 100 through the port.

The interface unit may be a path through which power from the cradle is supplied to the magnetic therapy apparatus 100 when the magnetic therapy apparatus 100 is connected to an external cradle or various command signals input from the cradle by the user And may be a passage that is transmitted to the magnetic therapy apparatus. The various command signals or the power source inputted from the cradle may be operated with a signal for recognizing that the magnetic treatment apparatus is correctly mounted on the cradle.

The controller 180 typically controls the overall operation of the magnetic therapy apparatus. For example, voice communication, data communication, video communication, and the like. The control unit 180 may include a multimedia module 181 for multimedia playback. The multimedia module 181 may be implemented in the control unit 180 or may be implemented separately from the control unit 180. [

The controller 180 may perform a pattern recognition process for recognizing handwriting input or drawing input performed on the touch screen as characters and images, respectively.

When the display unit 151 is formed of an organic light-emitting diode (OLED) or a TOLED (Transparent OLED), the controller 180 controls the display unit 151, When the preview image is pulled up on the screen of the organic light-emitting diode (OLED) or the TOLED (Transparent OLED) and the size of the preview image is adjusted according to the user's operation, The power consumption of the power source supplied from the power supply unit 190 to the display unit 151 can be reduced by turning off the driving of the pixels in the second area other than the first area in which the preview image is adjusted.

The power supply unit 190 receives external power and internal power under the control of the controller 180 and supplies power necessary for operation of the respective components.

The various embodiments described herein may be embodied in a recording medium readable by a computer or similar device using, for example, software, hardware, or a combination thereof.

According to a hardware implementation, the embodiments described herein may be implemented as application specific integrated circuits (ASICs), digital signal processors (DSPs), digital signal processing devices (DSPDs), programmable logic devices (PLDs), field programmable gate arrays May be implemented using at least one of a processor, controllers, micro-controllers, microprocessors, and other electronic units for performing other functions. In some cases, The embodiments described may be implemented by the control unit 180 itself.

According to a software implementation, embodiments such as the procedures and functions described herein may be implemented with separate software modules. Each of the software modules may perform one or more of the functions and operations described herein. Software code can be implemented in a software application written in a suitable programming language. The software code is stored in the memory 160 and can be executed by the control unit 180. [

In addition, the self-treatment voltage generator 200 plays a role of generating a self-treatment voltage.

Generally, electrical stimulation (electrical stimulation) and magnetic stimulation (magnetic stimulation) are used to treat the neuromuscular system of the body.

Among them, the magnetic stimulation method is a method in which stimulation is generated by inducing a magnetic field energy obtained by discharging a voltage charged in a capacitor to a magnetic field generating coil to skin or body tissue to generate an eddy current.

The principle of magnetic stimulation is fundamentally based on the Faraday 's law of electromagnetic induction. The Faraday' s law of electromagnetic induction induces an electromotive force proportional to the rate of decrease of magnetic flux in a circuit when the magnetic flux connected to the circuit changes.

In addition, the direction of the induced current flowing in the circuit by the electromagnetic induction is opposite to the change of the flux linkage of this circuit in accordance with Lenz's law.

Such magnetic stimulation is characterized in that it can stimulate deep parts in a noncontact manner. That is, it has attracted much attention as a therapeutic instrument because of its advantages of penetration effect compared with electric stimulation and suffering from pain or discomfort caused by electric stimulation.

Hereinafter, the configuration of the self-treatment voltage generator 200 will be described in detail.

The voltage generator 200 generates a time-varying magnetic field, and the generation of the time-varying magnetic field can be referred to as AC (alter-nating current) by reinterpreting it in general terms. In order to control the phenomenon of the initial oscillation at the low frequency, a series capacitor is used. In this case, since the capacity L value of the coil is designed to be several tens of μH to several mH, the output signal is closer to the square wave than the sinusoidal wave. Since the load of a square wave is a coil and the coil is a capacitive load, the output waveform of the actual coil becomes a trapezoidal shape rather than a square wave. Since the trapezoidal output waveform is a synthetic component of various frequencies, it is caused by the noise, but the waveform becomes a trimmed shape due to the capacity of the coil. These waveforms respond quickly to changes in the magnetic field, which is desirable for stimulation where changes in the magnetic field are important.

6 is a block diagram schematically showing the configuration of the voltage generator.

Referring to FIG. 6, the voltage generator 200 includes a main power supply 210, a DC / DC converter 220, a full bridge circuit 230, and a control device circuit 240.

The main power supply apparatus 210 may be configured to supply power for driving the voltage generator 200 and supply DC power. In one embodiment, the main power supply 210 may use a fixed power of 34V / 60A. When the main power supply apparatus 210 supplies DC power, it is not necessary to perform control to supply the AC power, so that the configuration of the main power supply apparatus 210 can be simplified.

The DC / DC converter 220 changes the size of the DC power source, and is selectively used in the present invention. When the main power supply device 210 supplies DC power, the DC / DC converter 220 is used to extend the frequency limit by changing the voltage as necessary since the main power is a fixed power source. In addition, the DC / DC converter 220 can be selectively applied to the present invention when the load is not a single load, that is, when two or more coils are used at the same time.

The full bridge circuit 230 is a device for switching the direction of the current flowing in the load. Here, the direction of the magnetic field is changed by switching the direction of the current applied to the coil. In addition, the full bridge circuit 230 may be configured to allow a large current to flow for the current of the coil.

Figure 7 illustrates an exemplary full bridge circuit.

Referring to FIG. 7, the full bridge circuit is capable of only controlling the A signal and the B signal, and the output of the full bridge circuit can change the direction of the current of the coil. When the control signal of A is generated, the diagonally arranged FETs are made conductive to make the current flow, and when the control signal of B is generated, the diagonally arranged FETs are turned on to form the opposite current flow. The direction of the magnetic field generated by the coil varies depending on the flow of the current.

Figure 8 shows another exemplary full bridge circuit.

Fig. 8 shows an improved full bridge circuit. As control signals, it is possible to input not only the A signal and the B signal, but also the A signal and the B signal. Here, the signals A and B represent signals whose phases are inverted in the A signal and the B signal, respectively.

6, the control element circuit 240 inputs a control signal to the full bridge circuit 230 to control the intensity of the magnetic field generated in the full bridge circuit 230. [ Since the characteristic of the AC power source appears through the frequency, the control element circuit 240 first determines the frequency to generate the control signal. The control element circuit 240 then generates the signals A, A, B, B ^ of FIG. 8 to drive the full bridge circuit 230 based on the determined frequency. However, if the signal is input to the full bridge circuit 230, the intensity of the magnetic field corresponding to the frequency changes, and the same magnetic field can not be maintained constant depending on the frequency. Therefore, the control element circuit 240 generates a signal that changes the duty of the A, A, B, and B signals. Thus, a frequency dependent duty change can be obtained, which can be used to produce the same magnetic field strength according to frequency.

The control element circuit 240 can improve the control signal for control of various waveforms. Fig. 9 shows generation of a control signal with a parallax in the control element circuit. The cause of the parasitic difference in the control signal is to reduce instantaneous short circuit when the FET connected in series to the power supply and GND is switched in the driving of the large current.

10 is a diagram illustrating an exemplary combination of a main power supply and a DC / DC converter.

Referring to FIG. 10, the main power supply device 210 is composed of, for example, a SMPS (Switching mode power supply) power supply device, and supplies a commercial power supply of 60 V. The use of SMPS as the main power supply 210 is optional because the SMPS power supply has a complicated structure and a large size when a large current is required but a variable voltage is required.

Next, the DC / DC converter 220 is constituted by, for example, a PWM (Pulse Width Modulation) method to make a power source related to the intensity of the magnetic field. The main power supply 210 smoothes the output power of the switching system and generates a desired stable power while passing through the noise filter. If the characteristics of the output element are sufficiently used, the desired power of 30 A have.

The control of the DC / DC converter 220 for generating the power to be used in the full bridge circuit 230 is performed through the control element circuit 240. The control element circuit 240 uses a separate dedicated circuit or element It is possible to embed the control program so as to control it through the program. The full bridge circuit 230 can vary the power from 5 V to 60 V and the variable power source is supplied to the coil through the full bridge circuit 230 as shown in FIG.

11 shows an exemplary central processing circuit of a control element circuit.

In FIG. 11, a microprocessor is used as the central processing circuit, which controls the voltage of the DC / DC converter 220 and generates a control signal supplied to the coil of the full bridge circuit 230. The control signal supplied to the coil of the full bridge circuit 230 is generated by combining the four signals A, A, B, and B, and the frequency is varied by the program of the control device circuit 240. Various settings and conversions of the control circuit can be performed using the program of the control element circuit 240, and it is possible to have a considerable margin for changing or coping with the control signal.

The control element circuit 240 may include a setting input switch (not shown) that allows the user to vary the frequency and the output voltage. In addition, the user can grasp the current situation through the display unit 151, and can communicate with an external device such as a PC through the wireless communication unit 110 additionally. When the user uses the communication function through the wireless communication unit 110, the user can perform monitoring directly from the PC screen without using the setting input switch as well as monitoring from the external PC.

12 is a diagram showing a push full output for operation of a full bridge circuit.

In FIG. 12, current is supplied to the coil only when the A signal and the A signal having the inverted phase are simultaneously activated (Active). When this circuit is used as a bridge structure, the current direction of the coil can be changed according to the control signal.

13 is a diagram showing the flow direction of the current in the full bridge circuit.

Referring to FIG. 13, it can be seen that the direction of the current flowing when the signal A and the signal A is activated is different from the direction of the current flowing when the signal B and the signal B are activated. This principle is the reverse order of the process of rectifying AC using a bridge diode when rectifying. The current flowing through the coils is such that both power supplies of the supply voltage are alternately supplied. When the current flows to both sides of the coil, the alternating current flows. However, during control, the A signal and the B signal or the B signal and the A signal FET should not be operated at the same time because two FETs are turned on between the DC power sources before supplying power to the coils This results in short circuit operation in a circuit, and results in destruction of the output element. Therefore, it is preferable that the control signal generated by the control element circuit 240 is generated with a parallax as shown in Fig.

Hereinafter, the present invention will be described in more detail with reference to Examples and Experimental Examples. However, the scope of the present invention is not limited by the following Examples.

<Experimental Method>

1. Cell culture

Rat basophilic leukemia RBL-2H3 was cultured in a 6-well plate. DMEM (Dulbecco's modified eagle medium) was used as a culture medium, and 5% PBS (Fetal bovine serum) and 1% penicillin were added thereto. The number of cells was divided into 1 × 10 cells on each plate, and the cells were incubated in the same incubator at 37 ° C.

2. With magnetic field

The magnetic field was changed and the magnetic field was applied to the control group without magnetic field and left and right after the application of magnetic field for 24 hours at maximum for 72 hours. After the incubation, the number of cells was measured. Before entering the experiment, the doubling time (the time taken for doubling the number of cells) of RBL-2H3 was measured. And 48 hours in RBL-2H3.

3. Cell count (cell count)

Hemocytometer was used as a measurement tool.

4. How to measure cell number

1) The medium remaining on the plate was removed and washed with PBS (calcium and magnesium free D).

2) After trypsin addition, the cells were stored in a 37 ° C incubator for 10 to 15 minutes.

3) When the cells were dropped from the bottom, the medium was added, pipetted, transferred to a conical tube, and centrifuged. (for trypsin-EDTA inhibition)

4) The supernatant was removed, leaving only the cell pellet.

5) After adding 1 ml of PBS (calcium and magnesium free D), the cell pellet was washed by pipetting and centrifuged.

6) The supernatant was removed, leaving only the cell pellet.

7) medium and pipetted enough. Then, 10ul of the medium and 10ul blue of trypan blue were mixed and 10ul was added to both sides of the hemocytometer to count the number of cells.

Example 1. Magnetic field stimulation

Was applied to the rat basophilic leukemia RBL-2H3 using a magnetic field device. Specific magnetic field stimulation conditions are shown in Table 1 below.

Magnetic field stimulation condition Frequency (Hz) interval (%) 1 / f (sec) Gauss 2000 34 0.5 50 1500 25 0.66 50 1400 23 0.71 50 1200 20 0.83 50 1000 17 One 50 800 14 1.25 50 600 10 1.67 50 500 8 2 50 400 7 2.5 50 250 4 4 50 200 3 5 50

As a result of the experiment under the above conditions, the growth rate of RBL-2H3 cells was as shown in Table 2 below.

Cell proliferation rate (%) at 24 hours after 24 hours with magnetic field Frequency (Hz) Proliferation (%) 2000 91.42037 1500 82.62759 1400 77.70953 1200 74.16997 1000 76.64739 800 88.30831 600 96.82491 500 95.23001 400 85.93533 250 83.15659 200 96.80317

As a result, the proliferation of RBL-2H3 cells was suppressed to some extent in the frequency band of 250 to 500 Hz, but the proliferation inhibition effect was excellent in the frequency band of 800 to 1500 Hz.

Claims (14)

A main power supply device including a DC / DC converter for supplying a DC power source and changing a size of the DC power source;
A full bridge circuit for switching the direction of the current applied to the coils in the circuit; And
And a control element circuit for inputting a control signal relating to a direction of a current applied to the coil and a magnitude of a power source so as to control the intensity of a magnetic field generated in the coil of the full bridge circuit,
The control element circuit generates signal pairs whose phases are inverted to control the direction of the current applied to the coil, and the full bridge circuit is operable to apply a current to the coil only when the phase inverted signal pair is simultaneously active, Lt; RTI ID = 0.0 &gt; a &lt; / RTI &gt; push full output,
Characterized in that the control element circuit generates a signal with a time lag in order to prevent a short circuit that may occur as two FETs are operated between the DC main power supply. delete delete The apparatus of claim 1, wherein the control element circuit includes a setting input switch for manually varying the frequency and the output voltage. delete delete delete The method according to claim 1,
Wherein the magnetic field has a frequency of 1,000 Hz to 1,400 Hz and a magnetic field of 10 to 100 Gauss intensity. 9. The method of claim 8,
Wherein the magnetic field is 30 to 70 Gauss intensity. 9. The method of claim 8,
Wherein the intensity of the magnetic field is 40 to 60 Gauss. 9. The method of claim 8,
Wherein the magnetic field is applied for 0.5 hours or more. 9. The method of claim 8,
Wherein the magnetic field is applied for at least 1 hour. 9. The method of claim 8,
Wherein the magnetic field is applied for 6 hours or more. 14. The method according to any one of claims 8 to 13,
Wherein the magnetic field is applied for the prevention and treatment of leukemia.

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