KR101344061B1 - Toothbrush Cleaner Composition - Google Patents

Abstract

The present invention relates to a toothbrush cleaner composition, and provides a toothbrush cleaner that contains peroxides to sterilize bacteria inhabiting the toothbrush.

The peroxide contained in the composition of the present invention exhibits excellent bactericidal power against bacteria with high oxidizing power and is effective in clean and hygienic use and care of the toothbrush.

Toothbrush Cleaner, Peroxide

Description

Toothbrush cleaner composition {Composition for cleaning toothbrush}

The present invention relates to a toothbrush cleaner composition, and more particularly, to a toothbrush cleaner composition containing a high oxidizing power peroxide to sterilize bacteria inhabiting the toothbrush.

Toothbrushes in use include hepatitis, Listeria, and meningitis, including Vibrio, which causes enteritis, sepsis, diarrhea, vomiting, and abdominal pain, and E. coli, abdominal cramps, nausea, and nausea, which can cause cystitis and pyelitis. About 28 kinds of bacteria such as bacteria, Salmonella, Staphylococcus aureus, tetanus bacteria, Diphtheria bacteria, Mycobacterium tuberculosis, and cholera bacteria are inhabited, and there is a risk of infection through the oral cavity of the teeth.

Recently, as interest in hygiene of consumers increases, toothbrush sterilizers using light sources such as ultraviolet rays are sold and used in the market, but there are problems such as relatively high price and the need to use a separate power source.

In Korean Patent Laid-Open No. 2004-54875, at least one compound selected from the group consisting of benzalconium chloride (Benzalconium Chloride), benzenetonium chloride (Benzotonium Chloride), and cetylpyridinium chloride (Cetyl Pyridinium Chloride) is used as an effective cleaning agent. Toothbrush cleaner compositions are described. The detergent active ingredient mentioned in the present invention is a cationic fungicide, and when mixed with a substance such as an anionic surfactant, has a disadvantage in that its activity is significantly reduced by forming a complex.

Korean Patent Registration No. 462903 discloses an interdental toothbrush equipped with a disinfectant and a cleaning solution that provides a function of improving cleaning power and gums when interdental cleaning is provided by itself with a disinfectant and a cleaning solution, but disinfectant and cleaning solution are not specifically specified. And, in particular, there is no disclosure of detergent compositions containing peroxides.

Korean Patent Registration No. 444183 is equipped with a dental floss that removes foreign substances between teeth in a cleaning paper that can wipe off food residues on teeth so that foreign substances can be easily removed from the teeth without getting discomfort. Although dental cleaning papers having dental floss embedded therein have been disclosed, there is no disclosure of a cleaning composition containing a peroxide, in particular using a physical cleaning means.

Korean Patent Registration No. 146618 discloses a liquid composition for toothbrush storage containing a fungicide and cellulase selected from chlorohexidines, quaternary ammoniums, parabens, antibiotics, and triclosan. There is no.

It is an object of the present invention to provide a toothbrush detergent composition which exhibits excellent sterilizing power against various bacteria inhabiting a toothbrush and has hygienic toothbrush management, which has a property of not degrading sterilization activity during storage and use.

The present inventors have found that the above object can be achieved by using a peroxide as a fungicide among the components of the toothbrush cleaner composition.

The present invention provides a toothbrush cleaner composition characterized in that the peroxidant is formulated with a high oxidizing power to sterilize the bacteria inhabiting the toothbrush.

Hereinafter, the present invention will be described in detail.

The toothbrush cleaner composition of the present invention preferably contains 0.1 to 70% by weight of peroxide based on the total weight of the total composition. If the content of the peroxide exceeds 70% by weight, the increase in sterilization effect relative to the content is small and inefficient. If the content is less than 0.1% by weight, it is difficult to obtain the expected sterilization power. More preferably, 10 to 60% by weight of peroxide is prescribed.

Peroxides used in the present invention may be used alone or in combination with potassium persulfate, sodium perborate, sodium percabonate, hydrogen peroxide, urea peroxide, and the like. have.

Peroxides may vary in stability depending on pH, so it is necessary to adjust the pH, and the appropriate pH range of the composition is pH 2-5. If the pH is too low, less than 2, there may be problems such as skin irritation, and if the pH is too high, there may be disadvantages in that the peroxide is decomposed to reduce sterilization power.

Accordingly, it is preferable to add a pH adjusting agent to the composition of the present invention, the pH adjusting agent in the present invention is a component necessary for increasing the storage stability and sterilization effect of the peroxide.

As the pH adjusting agent, sodium phosphate, disodium phosphate, trisodium phosphate, sodium pyrophosphate, sodium citrate, citric acid, tartaric acid, and the like can be used. Particularly, tartaric acid and citric acid, which are effective for increasing storage stability and bactericidal effect of peroxides, are preferable.

If the amount of the pH adjuster is added too much, the degree of increase of the pH control effect relative to the content is small and inefficient, and if it is too small, it is difficult to obtain the expected pH control effect. Therefore, 0.1 to 50% by weight, preferably 1 to 30% by weight, is added alone or in mixture of two or more of the above-described pH adjusting agent.

As a washing | cleaning agent, sodium lauryl sulfate, the (alpha)-olefin sulfonate sodium, lauroyl sarcosin sodium, fatty acid monoglyceride sodium sulfate, etc. can be used individually or in combination. The detergent, ie, the surfactant, penetrates the toothbrush contaminants by lowering the surface tension, loosens the bond, and emulsifies and suspends the residue removed from the toothbrush, thereby increasing the toothbrush cleaning effect. If the amount of the detergent added is too large, the degree of increase of the cleaning effect is small and inefficient, and if it is too small, it is difficult to obtain the expected cleaning effect. Therefore, 0.1-10 weight%, Preferably 0.5-5 weight% is added in the above-mentioned detergent alone or in mixture of 2 or more types.

The toothbrush cleaner composition of the present invention is not particularly limited in its formulation, and may specifically have a formulation such as tablet, liquid, powder, capsule, and the like.

For example, in the case of tablets, it may contain a blowing agent, an excipient, a binder, a lubricant, a pH adjuster, a cleaning agent, a dye, a perfume.

As the blowing agent component, sodium hydrogen carbonate, potassium hydrogen carbonate, ammonium hydrogen carbonate and the like can be used. Among them, 1 to 60% by weight, preferably 10 to 50% by weight, may be used alone or in combination of two or more thereof. If the content is too small, it is difficult to obtain the expected foaming force. If the content is too large, the effect increase compared to the content is not large, which is inefficient.

As the excipient component, lactose, starch, microcrystalline cellulose, and the like may be used. Among them, 1 to 50% by weight may be used alone or by mixing two or more kinds. If the content is too small, it is difficult to form the form of the formulation, if too large it is inefficient because the effect increase compared to the content is not large.

As the binder component, polyvinylpyrrolidone, carboxymethyl cellulose, hydroxyethyl cellulose, hydroxypropyl cellulose, xanthan gum, carrageenan, sodium alginate, and the like may be used, and 0.1-10 wt. Use%. If the content is too small, it is difficult to maintain the binding strength of the formulation, if too large it is inefficient because the effect increase compared to the content is not large.

As the lubricant, silicon dioxide, magnesium stearate, hard silicic anhydride, talc, and the like may be used. Among them, 0.01 to 5% by weight, preferably 0.1 to 2% by weight, may be used alone or in combination of two or more thereof. If the content is too small, it is difficult for tablets to come out of the mold during tableting. If the content is too large, the effect increase is not large compared to the content, which is inefficient.

As a fragrance, peppermint oil, spearmint oil, menthol, anetol and the like are mixed and used in an appropriate amount.

Toothbrush cleaners in the tablet form of the present invention are prepared by a conventional tablet manufacturing method, the weight of one tablet is 0.5 to 5.0 g, preferably 1.0 to 2.0 g. As a method of use, the toothbrush dissolved in 50 to 300 mL of water is sterilized and sterilized by soaking the used toothbrush for at least 1 minute, more preferably 5 to 30 minutes.

Hereinafter, the present invention will be described in more detail with reference to Examples and Comparative Examples. However, the scope of the present invention is not limited thereto.

[Examples and Comparative Examples] Toothbrush cleaner

Tablets as a toothbrush detergent composition were prepared in a weight of 1.0 g per tablet according to the conventional tablet preparation method according to the formulation of Table 1 below. In Table 1 below, polyvinylpyrrolidone was used as having a weight average molecular weight (M _w ) of 50,000.

[Table 1]

As can be seen in Table 1, in Example 1, potassium persulfate and sodium perborate were blended as a fungicide, and in Example 2, potassium persulfate and sodium percarbonate were blended. In Comparative Example 2, a pH adjuster was not used, and in Comparative Example 3, chlorohexidine used in the conventional invention was used instead of peroxide as a bactericidal component.

[Test Example 1] bactericidal power evaluation

In this test, the bactericidal activity against microorganisms was evaluated to compare the bactericidal effects of the toothbrush cleaners prepared in each example and the comparative example.

Four isolates of S. aureus , P. aeruginosa , E. coli , and Candida ( C. albicans ) were used.

Only the head was cut from the toothbrush, soaked in 70% ethanol for 1 hour and sterilized, and then dried in a dryer for 2 hours. Toothbrush heads were immersed in a solution (0.5% bovine serum albumin) mixed with the above four bacteria at a level of 1 to 5 ㅧ 10 ⁷ CFU / mL and dried at 25 degrees for 2 to 3 hours. The dried toothbrush head was placed in a solution of one toothbrush cleaner in 150 mL of tap water, and the number of viable cells was measured by removing the toothbrush head every 5 minutes, 10 minutes and 20 minutes. The evaluation results are shown in Table 2.

[Table 2]

As can be seen in Table 2, in the case of Comparative Example 1, the mortality rate was relatively very low, and in the case of Example 1 and Example 2, the higher the peroxide content, the higher the mortality rate. In particular, Example 2 showed a mortality rate of 99% after 5 minutes of use. In addition, in the case of Comparative Example 2, the killing rate was lower than that in Example 1 because the pH regulator was not prescribed. In Comparative Example 3, chlorhexidine, a cationic fungicide, reacted with the anionic surfactant to decrease the fungicidal activity.

In order to confirm the bactericidal effect according to the storage period of the toothbrush cleaner according to the present invention, the tablets prepared in Examples 1 and 2 were left at room temperature for 6 months in the air, and then the bactericidal power was evaluated by the method of Test Example. It showed more than 95% bactericidal power.

As described above, the toothbrush cleaner composition according to the present invention shows an excellent bactericidal power against various bacteria inhabiting the toothbrush and has the advantage of being able to use and manage the toothbrush hygienically in a convenient way. In addition, there is an effect of maintaining excellent sterilizing power even if the storage engine passes.

Claims (6)

10 to 60% by weight, based on the total weight of the total composition, at least one peroxide selected from potassium persulfate, sodium perborate and sodium percarbonate 0.1 to 50% by weight, based on the total weight of the total composition, at least one pH adjuster selected from tartaric acid and citric acid; And 0.1 to 10% by weight, based on the total weight of the total composition, at least one detergent selected from sodium lauryl sulfate, sodium α-olefin sulfonate, sodium lauroyl sarcosine and sodium fatty acid monoglycerides; Toothbrush cleaner composition comprising a toothbrush cleaner composition, characterized in that the pH of the toothbrush cleaner composition is 2 to 5. delete delete delete delete delete