KR100992041B1 - Transdermal patch and its manufacturing method - Google Patents

Abstract

Provided is a transdermal patch that can be simply and stably attached to an adhesive sheet without scattering powdery transdermal agents, and a method for producing the same. A plurality of substrate pieces formed with a size sufficiently larger than that of the first release paper 1 having the plurality of hole portions 11 formed in a thermal shape and the hole portion 11, and the adhesive surface 21 being formed on one side thereof. (2) and the 2nd release paper 5 attached to the back surface 12 of the said 1st release paper 1, and are comprised, The surface 13 of the release paper 1 of the said (1) The plurality of substrate pieces 2 are each sealed to the hole 11 so that the adhesive surfaces 21 of the plurality of substrate pieces 2 are adhered to each other. On the back surface 12 of 1 release paper 1, powdery transdermal agent 3 is applied to a portion exposed from the hole portion 11 on the adhesive face 21 of the substrate piece 2, The 2nd release paper 5 is made to adhere | attach on the back surface 13 of the 1st release paper 1 so that the part which apply | coated the powdery transdermal agent 3 exposed from the said hole part 11 was prevented.

Transdermal patch

Description

Transdermal patch and its manufacturing method {TRANSDERMAL PATCH AND METHOD OF PRODUCING THE SAME}

The present invention relates to a transdermal patch and a method for producing the same which can be easily manufactured while alleviating pain of muscles and the like.

Conventionally, as a transdermal patch for relieving muscle pain and the like, a pellet-shaped permanent magnet or the like is provided on an adhesive sheet and attached to a painful portion, and the magnetic force lines emitted from the permanent magnet are contained in blood. There was a thing that promotes blood flow by acting on (see Patent Document 1, for example).

However, since the permanent magnet is a hard magnetic steel, there is a problem that the patient feels discomfort when it is attached to the affected part.

Therefore, in recent years, transdermal patches have also been developed in which, instead of the permanent magnets, a powdery transdermal agent having analgesic action is applied to the adhesive sheet, and this is applied to the painful part to alleviate the pain of the patient. , See Patent Document 2)

Patent Document 1: Japanese Patent Application Laid-Open No. 2002-224228

Patent Document 2: Japanese Patent Application Laid-Open No. 2003-292446

However, since a powdery transdermal agent is easy to scatter, there exists a problem that it is difficult in manufacture to adhere this transdermal agent to an adhesive sheet well.

Therefore, it was also conceived to apply the drug in which the pressure-sensitive adhesive was mixed into the powdery transdermal agent on the back side of the base sheet, and to manufacture it, but since it requires the effort of kneading the pressure-sensitive adhesive, it is necessary to dry the pressure-sensitive adhesive. There was.

Moreover, although magnesium carbonate powder is known as a powdery transdermal agent which has analgesic action, for example, this magnesium carbonate powder has a high analgesic effect, but when the amount is too large, the attached affected part is according to the site | part. In some cases, the powdery transdermal agent having an analgesic action must be applied to the adhesive sheet in an amount of a certain amount, and this production is particularly difficult due to the above problem.

This invention aims at solving such a subject, Comprising: It provides the transdermal patch agent which can be simply and stably adhered to an adhesive sheet, and a manufacturing method for it, without kneading a powdery transdermal agent with an adhesive.

In order to achieve the above object,

The transdermal patch according to claim 1 includes a first release paper having a plurality of hole portions formed in a thermal shape, a plurality of base pieces formed with a size larger than that of the hole portion and having an adhesive surface on one side thereof, and the first agent. It is comprised combining the 2nd peeling paper attached to the back surface of 1 peeling paper, The said several base piece adheres to the surface of the said 1st peeling paper so that each may block the hole part of a said 1st peeling paper, The said A powdery transdermal agent is applied to a portion of the adhesive surface exposed from the hole on the back side of the first release paper, and the second release paper is a portion coated with the powdery transdermal agent exposed from the hole of the first release paper. It is made to be attached to the back side of the first release paper.

In this, since a powdery transdermal agent is apply | coated to the adhesive part exposed from the hole part of the back surface of a 1st release paper, without making an adhesive knead, manufacture can be made easy.

In addition, since the powdery transdermal agent is sprayed into the hole on the back side of the first release paper, the excess is removed by a brush or the like, so that only the fixed amount according to the volume of the hole is adhered in that it does not become acid free. Can be.

In the percutaneous patch according to claim 2, the cut from the edge of the first release paper to the hole is formed in the hole of the first release paper.

In this case, since the incision from the edge of the release paper to the hole portion is formed, the release paper can be easily peeled off by simply twisting the incision without placing a claw on the circumferential edge of the release paper. Smell can also be made easy.

The transdermal patch according to claim 3 is the powdery transdermal agent according to claim 1 or 2, which contains magnesium carbonate powder as a main component.

In this case, the powdery transdermal drug contains magnesium carbonate powder as a main component, and the magnesium carbonate powder comes into contact with the skin such as the trigger point of the human body, thereby obtaining a high analgesic effect.

Here, magnesium has a function of inhibiting the transmission of the neuromuscular junction in the peripheral nervous system, and its mechanism of action mainly acts on the nerve terminal to reduce the amount of release of the neurotransmitter acetylcholine. It also has the function of activating the enzyme ATPase and acting on the ion transport mechanism to maintain a gradient of potassium ion concentration related to muscle pain.

On the other hand, about 90% of the invasion receptors of human skin are various types that respond to all of mechanical stimulation, chemical stimulation, and thermal stimulation.

Therefore, magnesium carbonate powder, which is safe even in the powder state, is used as the main component of the transdermal agent in order to act as a stimulus to the skin in a powder state that is unlikely to cause skin damage.

The transdermal patch agent according to claim 4 is the powdery transdermal agent according to claim 1 or 2, wherein any one or more metal powders of copper, aluminum, silver, and gold are blended with magnesium carbonate powder.

This has the effect of moderately reducing the discomfort caused by the magnesium carbonate powder.

Here, the magnesium carbonate powder has a strong analgesic effect, and depending on the symptoms, the magnesium carbonate powder may have an excessively strong effect.

Therefore, in order to apply an appropriate stimulus to the human body, the stimulation caused by the magnesium carbonate powder can be appropriately alleviated by mixing and mixing any one or more metal powders of copper, aluminum, silver and gold with the magnesium carbonate powder. .

Here, any one kind means the metal powder of copper, aluminum, silver, and gold, If these metal powders are mix | blended with magnesium carbonate powder according to a use, the stimulation by this magnesium carbonate powder can be moderately alleviated, and a use is carried out. It can be proved by the experiment that the effect according to.

In the present application, in addition to general muscle pain, it is chronic pain, sagging of the body, adjustment of the intestine (adjustment other than pain), arthralgia, etc., and it is proved that it is effective for each of these symptoms. In the process.

Moreover, although metal powders other than the above, for example, metal powders, such as titanium, can also be mix | blended, these compounding quantities, an effect | action, an effect, etc. are currently experimenting.

When the metal powder blended in this way is applied to the skin, all components such as moisture caused by sweating and salts contained therein act as a kind of aqueous electrolyte, so that a potential arises between metal powders having different ionization tendencies, As a result of stimulating the trigger point of the human body and the like, the blood flow on the surface of the skin is promoted, the metabolism is improved, and the cause of pain is eliminated by the synergistic effect with magnesium carbonate. Doing.

In addition, by stimulating the foot point, acts on the parts of the body related to the foot point, for example, by attaching to the foot point of the ear, sagging and sagging of the face, size of the eyes, bust up ), Abdominal pull, hip up, and the like.

Above all, depending on the symptoms and effects, the type and amount of the metal powder to be blended may be changed. Specifically, when the metal powder of aluminum, copper (or gold) is blended in the magnesium powder at the same ratio, It has been proven to be effective in relieving chronic pain and shaping up parts of the body.

Since the effect of such a shape up is obtained, the transdermal patch of the present application can also be used as an aesthetic product such as beauty.

The manufacturing method of the transdermal patch agent of Claim 5 forms the adhesive surface on one side in the 1st release paper which formed the some hole part in the thermal form, and also has the several base piece formed in the dimension larger than the said hole part, respectively. Powdery transdermal to the adhesive surface of the substrate piece exposed from the hole in the back of the first release paper, the adhesive surface of the substrate piece is adhered to the surface of the first release paper to block one of the hole portion. After apply | coating an agent, it is made by sticking a 2nd release paper to the back surface of said 1st release paper so that these hole parts may be blocked.

In this method, since a base piece is stuck so that the hole part of a 1st release paper may be clogged, and a powdery transdermal agent is apply | coated to the back surface of the 1st release paper which exposes the opening of a hole part, without making it powder-free, From the opening of each hole part, it can adhere stably to the base piece adhesion surface.

Moreover, when a 2nd release paper is stuck to the back surface of a said 1st release paper, and a powdery transdermal agent is apply | coated so that a hole part may be blocked, a transdermal patch agent can be mass-produced simply under a simple installation.

The manufacturing method of the percutaneous patch agent of Claim 6 forms the adhesive surface in one side in the 1st release paper which formed the some hole part in the thermal form, and also the several base piece formed in the dimension larger than the said hole part, The adhesive face of each base piece adhere | attaches on the surface of the said 1st release paper, and it adhere | attaches so that one of the said hole parts may be stuck, and then it adheres to the adhesive face of the base piece exposed from the hole part of the back surface of the said 1st release paper. After sticking the percutaneous agent formed in this way, it is made to stick these 2nd release paper to the back surface of said 1st release paper so that these hole parts may be blocked.

In this method, since a base piece is stuck so that the hole part of a 1st release paper may be stuck, and a solid percutaneous agent is stuck on the back surface of the 1st release paper which showed the opening of a hole part, a transdermal agent will not be destroyed. From the opening of each hole part, it can adhere stably to the adhesive surface of a base piece.

Here, the solid transdermal agent can be produced simply by, for example, containing a binder in a powdered transdermal agent and press molding into a desired shape. Patches can be mass produced simply under a simple installation.

According to the present invention, the following effects are obtained.

According to the transdermal patch according to claim 1, the powdery transdermal agent is applied to the adhesive portion exposed from the hole on the back side of the first release paper without kneading the adhesive, so that the production can be facilitated.

In addition, since the powdery transdermal agent is sprayed into the hole on the back side of the first release paper and the excess is removed by a brush or the like, only the fixed amount according to the volume of the hole can be adhered since there is no scattering. .

According to the transdermal patch according to claim 2, since an incision from the edge of the release paper to the hole is formed, the release paper can be easily peeled off simply by twisting the incision without placing a claw on the peripheral edge of the release paper. This can also facilitate removal of the substrate piece.

According to the transdermal patch according to claim 3, since the powdery transdermal drug contains magnesium carbonate powder as a main component, and the magnesium carbonate powder is in contact with the skin such as the point of entry of the human body, a high analgesic effect is obtained.

According to the transdermal patch according to claim 4, since the powdery transdermal agent mixes any one or more metal powders of copper, aluminum, silver, and gold with magnesium carbonate powder, the effect of appropriately alleviating the discomfort caused by magnesium carbonate powder There is. In addition to the analgesic action of magnesium carbonate powder, a synergistic effect of the combination of the blended metal powders can be obtained.

In particular, when the trigger point is stimulated by the transdermal patch of the present application, it acts on each part of the body related to the trigger point, for example, by attaching it to the ear point, thereby activating the muscle of the corresponding site, You can get the effect of sagging and wrinkles on the face, preventing sagging of the eyelids, busting up, pulling on the abdomen, and hip-up.

According to the method for producing a transdermal patch according to claim 5, a powdery transdermal agent is applied to the back surface of the first release paper which sticks the base piece so as to close the hole of the first release paper, and exposes the opening of the hole. Since it apply | coats, it can stably adhere to the adhesive surface of a base piece from the opening of each hole part, without making it powder-free.

In addition, when the powdery transdermal agent is applied to the back surface of the first release paper by attaching the second release paper so as to close the hole, the transdermal patch agent can be easily mass-produced under a simple facility.

According to the method for producing a transdermal patch according to claim 6, the base piece is attached so as to close the hole of the first release paper, and the solid percutaneous agent is adhered to the back side of the first release paper which exposes the opening of the hole. It is possible to stably adhere to the adhesive face of the base piece from the opening of each hole, without causing the transdermal agent to disperse.

In addition, when the adhesive is made by blocking the pores with a solid transdermal agent, the transdermal patch agent can be mass produced simply under a simple facility.

BRIEF DESCRIPTION OF THE DRAWINGS Fig. 1 is a perspective view schematically illustrating an embodiment of a transdermal patch agent (A) and a method for producing the same according to the present invention.

FIG. 2: is a principal part perspective view which enlarged a part of transdermal patch agent (A) shown in FIG.

FIG. 3 is a partially enlarged cross-sectional view of a part of the transdermal patch A shown in FIG. 1.

(Explanation of the sign)

 A: transdermal patch agent 1: first release paper

11: hole 12: (first release paper) surface

13: (1st release paper) back side 2: base material

21: adhesive side 3: (powdery, solid) transdermal

 5: 2nd release paper 6: incision

EMBODIMENT OF THE INVENTION Hereinafter, the transdermal patch agent (A) which concerns on this invention is demonstrated with drawing.

Example 1

1 is a perspective view schematically illustrating an embodiment of a transdermal patch agent (A) and a method for producing the same according to the present invention, and FIG. 2 is a perspective view of a main portion partially enlarged in part of the transdermal patch agent (A) shown in FIG. FIG. 3 is a partially enlarged cross-sectional view of a part of the transdermal patch A shown in FIG. 1.

This transdermal patch (A) firstly forms a first release paper 1 having a plurality of hole portions 11 formed in a thermal shape, and an adhesive surface 21 formed on one side thereof, and further includes a hole portion ( 11) The 1st release paper was made by using the some base piece 2 formed in the dimension sufficiently larger than 11), and each base piece 2 makes the adhesive surface 21 block the one side of the hole part 11. It adheres to the surface 12 of (1).

The first release paper 1 uses a thin resin sheet or paper sheet formed in a rectangular shape, but the surface 12 of the first release paper 1 is capable of adhering at least the adhesive face 21 of the base piece 2, The base material piece 2 after this adhesion is provided with peelable release property.

In the first release paper 1, circular hole portions 11 are formed at equal intervals, and a plurality of hole portions 11 are formed in a columnar shape. In addition, although the hole part 11 lined in 5 rows is illustrated in this embodiment, the number of columns and the number of steps are according to the external shape of the 1st release paper 1 or the magnitude | size of the base piece 2 It is chosen appropriately.

In addition, although the shape of the hole part 11 can be formed in various shapes, such as a circular shape and a square, the surface area of this hole part 11 is a powdery transdermal component mentioned later apply | coated to the said hole part 11 Thus selected.

The base piece 2 forms a deformable sheet material such as a nonwoven fabric in a shape that is sufficiently larger than that of the hole portion 11, and each base piece 2 is shown in the diagram on the right side of FIG. ) Is attached to the surface 12 of the first release paper 1 so that one of the holes 11 is blocked.

Next, as shown in the left figure of FIG. 1, this 1st release paper 1 is inverted and the part exposed from the hole part 11 of the back surface 13 of the 1st release paper 1, ie, a base piece ( A powdery transdermal agent 3 is applied with a brush 4 or the like toward the central portion of the adhesive face 21 of 2).

Specifically, after embedding the powdered transdermal agent 3 in the hole 11 with a brush 4 or the like, and removing the extra powdery transdermal agent 3 with the brush 4 or the like, the hole part Only a certain amount of powdered transdermal agent 3 is attached to (11), and a certain amount of powdered transdermal agent 3 can be applied.

Here, if the powdery transdermal agent 3 is composed mainly of magnesium carbonate powder, since high analgesic action is obtained, the adhesive surface of the base piece 2 depends on the diameter and depth of each hole 11. 21) can be stably coated.

In addition, since the analgesic action of magnesium carbonate powder is proportional to the application area, the strength and weakness of the analgesic action can be adjusted by the size of the hole 11.

Further, as a means for adjusting the analgesic action of magnesium carbonate powder, in the present invention, as the powdery transdermal agent (3), any one or more kinds of metal powders having different ionization tendencies, such as copper, aluminum, silver, gold, etc. The compounded thing is used.

The amount of these metal powders of copper, aluminum, silver, and gold, the kind of metal powder to be blended, and the like are selected according to the extent to alleviate the analgesic effect or the effect on the affected area, for example, the swelling of the muscle and the diet effect. .

Here, an example of the experimental results according to the present invention, if the copper powder and aluminum powder in the same amount as the magnesium carbonate powder is combined, the analgesic action of magnesium carbonate is alleviated, chronic pain and alleviation of chronic symptoms, muscle swelling And mitigating effects were obtained.

In addition, even when the same amount of gold powder and aluminum powder as the magnesium carbonate powder were blended, the analgesic action of magnesium carbonate was alleviated, and chronic pain and chronic symptoms were alleviated, and muscle swelling and relief were obtained.

In addition, it is possible to confirm that the whole body is pulled by attaching a transdermal agent 3 containing a copper powder (or gold powder) and an aluminum powder in the same amount as the magnesium carbonate powder to the ear point or irritation point. In particular, it was found that it is also effective in improving the sag and wrinkles of the face, preventing sagging of the eyelids, bust up, pulling the abdomen, and hip up.

In addition, although only the copper powder and the aluminum powder were blended, it was proved to be effective for the adjustment of the intestines (adjustment other than pain). In addition, a mixture of silver powder and aluminum powder in the same amount as the magnesium carbonate powder or carbonic acid was added. The present invention also relates to the effects of mixing all of the same amount of gold powder, silver powder and aluminum powder as magnesium powder, or mixing metal powders such as titanium powder other than the above, or changing the proportion of the blend. Experiment

Moreover, as a means other than apply | coating a fixed amount of powdery transdermal agent 3 to the hole part 11, for example, the spray gun which filled the powdery transdermal agent 3 (not shown) The powdery transdermal agent 3 may be blown into the hole 11 by using a), and then the extra powdery transdermal agent 3 may be removed.

Moreover, when using the container (not shown) which can blow the powdery transdermal agent 3 toward the some hole part 11 simultaneously, the working time which apply | coats the powdery transdermal agent 3 to the hole part 11 is shown. Can be further shortened.

And after apply | coating a fixed amount of powdery transdermal agent 3 to all the hole parts 11, it is made to block those hole parts 11, and is made toward the back surface 13 of this 1st release paper 1. It is made by attaching 2 release papers 5.

Moreover, as another method, the percutaneous agent 3 formed in solid shape was affixed toward the hole part 11 of the back surface 13 of the 1st release paper 1 so that these hole parts 11 may be filled. It is also possible.

In addition, the solid transdermal agent 3 can be produced simply by, for example, incorporating a binder into the powdery transdermal agent 3 and then press molding into a desired shape with an existing forming machine or the like.

Even when using the transdermal agent 3 previously formed in solid form in this way, it adheres stably to the adhesive surface of the base piece 2 from the opening of each hole part 11, without making the transdermal agent 3 dissolve. can do.

The second release paper 5 is not adhered to the exposed powdery transdermal agent 3 in order to prevent dust or the like from adhering to the powdery transdermal agent 3 exposed from the hole 11, and What is necessary is just to adhere to the back surface 13 of a 1st release paper, For example, the transparent thin film sheet is formed in the same shape as the 1st release paper 1, and this film sheet is formed on the back side 13 of a 1st release paper. Attach to

In addition, the second release paper 5 may be provided with a perforation line so as to be divided according to each base piece 2, or the second release paper 5 is individually attached to protect only a portion of the powdery transdermal agent 3. It does not matter.

The transdermal patch (A) of the present invention thus formed is used in the following manner.

First, one base piece 2 is peeled off from the surface 12 of the first release paper 1, and the powdery transdermal agent 3 applied to the center of the adhesive surface 21 of the base piece 2 is removed. The adhesive face 21 of the base material piece 2 is pressed against the skin of the patient while being positioned at the point of pain of the patient.

In the same manner, the necessary number of pieces of the base piece 2 is sequentially peeled off from the surface 12 of the first release paper 1, and the adhesive face 21 of the base piece 2 is pressed against the skin of the patient.

Thus, by the powdery transdermal agent 3 of the base material piece 2 which stuck to the skin of a patient, moderate analgesic action by magnesium carbonate powder acts on a patient, or in addition to this analgesic action, Various effects possessed by other metal powders can be obtained in the same manner.

Furthermore, according to the solid transdermal agent 3, the same effect as the powdered transdermal agent 3 can be obtained in that the solid transdermal agent 3 appropriately stimulates the pain point of the patient.

In addition, when the incision 6 extending from the edge of the 1st release paper 1 to the hole part 11 is formed, the base piece 2 is easily peeled from the surface 12 of the 1st release paper 1 can do.

INDUSTRIAL APPLICABILITY The present invention can be effectively used as a transdermal patch that can be simply and stably attached to an adhesive sheet without scattering powdery transdermal agents.

Claims (6)

A first release paper having a plurality of hole portions formed in a thermal shape, a plurality of base pieces having a larger dimension than the hole portion, and having an adhesive surface formed on one side thereof, and a second sticking back surface of the first release paper. Combinations of release papers consist of: The plurality of substrate pieces are adhered to the surface of the first release paper by blocking the hole portions of the first release paper, and the parts of the adhesive surfaces exposed from the hole portions of the back surface of the first release paper. A powdery transdermal agent is applied, and the second release paper is attached to the back surface of the first release paper so as to block a portion where the powdered transdermal agent exposed from the hole of the first release paper is applied. Transdermal patch. The method of claim 1, The first release paper is formed with an incision from the edge to the hole portion, wherein the percutaneous patch agent. The method according to claim 1 or 2, The powdery transdermal agent is a transdermal patch comprising a magnesium carbonate powder as a main component. The method according to claim 1 or 2, Said powdery transdermal agent is a transdermal patch agent characterized by mix | blending any 1 or more types of metal powders of copper, aluminum, silver, and gold with magnesium carbonate powder. The 1st peeling paper which formed the some hole part in the column shape, the adhesive surface was formed in one side, and the some adhesive piece of each base piece formed in the dimension larger than the said hole part is the said 1st foil Adheres to the surface of the ridge, adheres to block one of the holes, Subsequently, after apply | coating a powdery transdermal agent to the adhesive surface of the base piece exposed from the hole part of the back surface of a said 1st release paper, it is made by sticking a 2nd release paper to the back surface of a said 1st release paper so that these hole parts may be blocked. Method for producing a transdermal patch. The 1st peeling paper which formed the some hole part in the column shape, the adhesive surface was formed in one side, and the some adhesive piece of each base piece formed in the dimension larger than the said hole part is the said 1st foil Adheres to the surface of the ridge, adheres to block one of the holes, Subsequently, after attaching the transdermal agent formed in solid shape to the adhesive surface of the base piece exposed from the hole part of the back side of the said 1st release paper, it is made by sticking a 2nd release paper to the back side of said 1st release paper so that these hole parts may be blocked. A method for producing a transdermal patch.

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