KR100963301B1 - Toothpaste composition containing hemp fiber as an active ingredient - Google Patents

Abstract

The present invention relates to a composition for oral cavity containing hemp fibers as an active ingredient, and more particularly, to an antibacterial toothpaste composition containing hemp fibers as an active ingredient.

Hemp Fiber, Toothpaste Composition

Description

Toothpaste composition comprising hemp fiber

The present invention relates to a composition for oral cavity containing hemp fibers as an active ingredient, and more particularly, to an antibacterial toothpaste composition containing hemp fibers as an active ingredient.

According to the World Health Organization's research and statistics on modern people's teeth and oral disease, 97% of people living in culture now suffer from dental diseases, and the problem is caused by the overuse of low-fiber foods and sugar. It is due to the increase in sweetness poisoning of the gums day by day, the invasion state of lactic acid in the oral cavity, and the increase in bacteria and viruses in the mouth due to lactic acid is further spread.

Therefore, the mortality rate of oral cancer is increasing to occupy the seventh place of cancer death, and the death from cerebral infarction and cardiac coronary infarction due to viral erosion of the blood vessels of the gum is increasing. In addition, various oral diseases are caused by plaque composed of numerous bacteria in the oral cavity, and the reason why many kinds of various bacteria can grow in the oral cavity is because it has a sufficient environment suitable for the growth of bacteria.

In general, dental caries is caused by various kinds of oral bacteria to produce cohesive polysaccharides, so that each bacteria easily adheres to the tooth surface and forms plaques where bacteria are collected. Bacteria break down sugars to produce acids, which demineralize the tooth's enamel surface to advance tooth decay. As plaque further progresses to calculus, it causes gingivitis, gingivitis, and periodontal disease of alveolar pylori.

It is reported that there are various side effects when using antibiotics, fungicides, etc. as a method for preventing such oral diseases [J. Dent. Res., 25, 441 (1946), J. Dent. Res., 31, 421 (1966), J. Oral Ther. Pharmacol., 3, 157 (1966), J. Am. Dent. Ass., 87 1006 (1973).

Conventionally, ointment-like toothpaste compositions which are generally used have been prepared by appropriate addition of other necessary ingredients, including tooth abrasives, wetting agents, binders and pigments, perfumes and the like. However, these toothpaste compositions were not intended to prevent and treat oral diseases such as toothache and periodontitis because their main purpose was to clean the teeth. However, at present, research and development of natural materials to be included in the toothpaste composition for the purpose of preventing tooth wear and treating oral diseases have been actively conducted.

The present invention solves the above problems and the object of the present invention is to provide a composition for oral cavity for the purpose of the treatment of oral diseases.

The present invention to achieve the above object

Provided is a toothpaste composition comprising hemp fibers as an active ingredient.

In one embodiment of the present invention, the amount of the hemp fiber is preferably 0.1 to 5% by weight based on the total toothpaste composition, but is not limited thereto.

In one embodiment of the present invention, the thickness of the hemp fibers is preferably 10 ~ 900㎛ and the average length of the hemp fibers is preferably 100 ~ 1000㎛, but is not limited thereto.

In addition, the toothpaste composition of the present invention has an antimicrobial activity, preferably in the form of a liquid, paste or transparent gel type, but is not limited thereto.

In another aspect, the present invention comprises the steps of a) cutting and grinding hemp fibers; b) sterilizing the ground hemp fibers; And c) mixing the sterilized hemp fibers into a mix comprising an abrasive, a binder, a moisturizer, a foaming agent, a sweetener, and a flavoring component.

In one embodiment of the present invention, step a) of the method is preferably a step of pulverizing the hemp fibers after lyophilization, but is not limited thereto, the hemp fibers of step a) is more preferably dried. .

In one embodiment of the manufacturing method of the toothpaste composition of the present invention, the thickness of the ground hemp fibers is preferably 10 ~ 900㎛ and the average length of the hemp fibers is preferably 100 ~ 1000㎛, but is not limited thereto.

In the present invention, the term "hemp fiber" means "hemp fiber".

Hereinafter, the present invention will be described.

The present invention relates to a dentifrice composition comprising hemp fibers, and more particularly, to the tooth decay bacteria (Streptococcus mutans, Streptococcus sanguis, and Streptococcus salivarius) and periodontal pathogens (Actinomyces viscous, Actinomyces naeslundi, Bacteroides gingvals, Bacterosthusides, Bacteros and Bacteros) It relates to a composition for oral cavity, in particular toothpaste composition for preventing tooth decay and periodontal disease having antibacterial action against oral bacteria, including intermedius).

Hereinafter, the present invention will be described in detail.

The present invention relates to the formulation of hemp fibers in various oral compositions such as toothpaste, mouthwash, candy and chewing gum, and particularly relates to toothpaste compositions effective for caries and periodontal disease. The hemp fibers may be used by grinding and sterilizing. When the hemp fibers thus obtained are applied to various types of products and applied in the oral cavity, it is possible to prevent tooth decay and periodontal disease. The amount of the hemp fiber blended into the composition for oral cavity is preferably 0.001-10% (w / w), particularly 0.1-5% (w / w), of the total. Mouthwashes, candies and chewing gum.

Various oral compositions for carrying out the present invention should be prepared using suitable ingredients according to the type thereof, for example, in the case of toothpaste, dicalcium phosphate, calcium carbonate, calcium pyrophosphate, calcium metaphosphate, silicas, Abrasives such as aluminum silicate and aluminum hydroxide (10-60% of this product), carboxymethyl cellulose, hydroxymethyl cellulose, alginate, carrageenan, gum gum, polyvinyl alcohol, etc. (0.4-5%), polyethylene glycols Humectants such as sorbitol, glycerin polyvinyl alcohol, sodium lauryl sulfate, sodium lauryl sarcosinate, monoglyceride sulfate, sucrose fatty acid ester, polyoxyethylene hardened castor oil, polyoxyethylene polyoxypropylene copolymer, polyoxyethylene In addition to foaming agents such as sorbitan fatty acid esters, ingredients such as flavoring agents, saccharin, stevioside, sweeteners and preservatives It is mixed with water to prepare a conventional toothpaste manufacturing method. Toothpaste prepared by the addition of hemp fibers according to the present invention includes sodium fluoride, sodium monofluorophosphate, salt, allantoin, pyrophosphate, aminocaroroic acid, vitamins, doncrochlorophyll sodium, tranesamic acid, zinc chloride, triclosan Also, various active ingredients commonly used in toothpaste, such as cetylpyridium chloride and vinyl methyl ether / maleic acid copolymer, can be added. In addition, products such as mouthwashes, candies and chewing gum can be prepared by appropriately blending various ingredients according to the manufacturing method.

In addition, the hemp fibers of the present invention can act as a fine bristles, it is possible to reduce the amount of use of abrasives, etc. commonly used in toothpaste, because the hemp fibers of the present invention is a hollow structure and is a microstructured structure in a regular arrangement toothbrush It is possible to increase the role of and to generate a lot of bubbles to reduce the amount of foaming agents and the like commonly used in toothpaste.

Toothpaste composition of the present invention is composed of the following composition ratio.

Ingredient Content ratio (composition ratio) abrasive 10 to 60 Moisturizer 20 to 75 Binder 1.5 to 10 Foam 1 to 2 water 5-50 Active ingredient of the present invention 0.1 to 5 Preservative
0.2 to 1.6
Sweetener incense

The toothpaste composition of the present invention has excellent effects such as antimicrobial activity by using hemp fibers as an active ingredient, and hemp fibers themselves serve as fine bristles, thereby reducing the fine cleaning effect and the use of conventional abrasives used in toothpaste compositions. It is possible to provide an excellent dentifrice composition that maximizes the effect of brushing by generating a lot of foam and reduces the use of conventional foaming agents.

Hereinafter, the present invention will be described in more detail with reference to non-limiting examples.

However, the following examples are intended to illustrate the present invention and should not be construed as limiting the scope of the present invention.

An embodiment of the hemp fiber production of the present invention is as follows.

Hemp Fiber Production Example

The dried hemp fibers collected from the hemp stem were cut to 5 cm in length, and then rapidly frozen with liquid nitrogen and finely ground to an average 0.41 mm thickness using a mortar (Fig. 1). Thereafter, in order to remove bacteria that may be present in the fibers, sterilization was performed using an autoclave to obtain hemp fibers.

EXAMPLE

Preparation of Toothpaste Composition of the Present Invention

The binder and other additives were previously dispersed in the humectant, and the abrasive and the hemp fibers were added, followed by stirring for about 30 minutes.

Finally, the foaming agent and the flavoring agent were added, followed by stirring for 20 minutes in a vacuum to prepare a toothpaste composition of the present invention.

The main component of the toothpaste applied herein is 10.00 parts by weight of colloidal silicon oxide, 0.76 parts by weight of sodium monofluorophosphate, 0.10 parts by weight of aminocaproic acid, 2.00 parts by weight of sodium chloride, 0.20 parts by weight of allantoin chlorohydroxyaluminum, crushed hemp fiber 2.00 Parts by weight, 46.00 parts by weight of sorbitol (70%) as humectant, 2.00 parts by weight of glycerin as humectant, 2.50 parts by weight of polyethylene glycol 1500 as humectant, 0.15 parts by weight of paraoxybenzoic acid methyl as preservative, 0.10 parts by weight of xylitol as sweetener, stevio as sweetener Side 0.10 parts by weight, 5.00 parts by weight of hydrous silicic acid (Tixosil 43K) as a viscosity modifier, 0.80 parts by weight of sodium carboxymethylcellulose as a viscosity modifier, 0.10 parts by weight sodium alginate as a viscosity modifier, 2.00 parts by weight sodium lauryl sulfate as a foaming agent, flavoring agent 0.02 part by weight of tea extract, 0.10 part by weight of propolis extract, and grapefruit seed extract of flavoring in 0.05 0.1 part by weight of menthol as a flavoring agent, 0.60 part by weight of fragrance as a flavoring agent, and water used as the remainder.

[Comparative Example]

Preparation of Toothpaste Composition

In addition, in order to compare with the toothpaste composition of the present invention, a conventional toothpaste composition was prepared and used as a comparative example. The composition of the toothpaste composition of the comparative example is the same as the embodiment except that the active ingredient of the present invention except hemp fibers It was prepared in the same manner as in the above example.

[Experimental Example]

Badge Production Example

As a microbial medium, a Trytic Soy Agar (TSA) medium capable of culturing oral bacteria was used. The composition of the medium was as follows.

Trytose   20.0 g  Dexrose  1.0 g  Disodium phosphate  2.0 g  Potassium nitrate  1.0 g   Agar   1.0 g

The table is a table relating to the oral bacteria medium composition table (per 1L).

The manufacturing process

(1) 25 g of 1 L of distilled water was added to the TSA medium for 1 minute.

(2) Autoclave for 15 minutes in a 121 ℃ sterilizer.

(3) Pour an appropriate amount on Petri Dish and harden slowly.

(4) 24 hours at 36.5 ℃ culture was confirmed whether the medium was contaminated.

Oral Bacteria Culture Experiment

(1) Before brushing, saliva after brushing with saliva and toothpaste was collected at 5, 10 and 15 minute intervals, respectively.

(2) Before brushing, saliva after brushing with toothpaste containing saliva and hemp fibers was collected at 5, 10 and 15 minute intervals, respectively.

(3) After diluting the saliva samples of experiments (1) and (2) with 20 μl of each sample was plated on a TSA medium and incubated for 18 hours using a 36.5 ℃ thermostat, the resulting colony number was determined.

Saliva before brushing Saliva after brushing sample 1-1 (15 minutes before brushing) sample 1-4 (5 minutes after brushing) sample 1-2 (10 minutes before brushing) sample 1-5 (10 minutes after brushing) sample 1-3 (5 minutes before brushing) sample 1-6 (15 minutes after brushing)

The table shows the general toothpaste experiment-saliva before brushing and saliva samples after brushing (control).

Saliva before brushing  Saliva after brushing sample 2-1 (15 minutes before brushing) sample 2-4 (5 minutes after brushing) sample 2-2 (10 minutes before brushing) sample 2-5 (10 minutes after brushing) sample 2-3 (5 minutes before brushing) sample 2-6 (15 minutes after brushing)

The table shows Hemp Fiber Toothpaste Experiment-Saliva Before and After Brushing Saliva Sample (Experimental Group).

The results according to the experimental example are as follows.

In the experiment (1) experimented with regular toothpaste, saliva was collected before the dentition and oral bacteria were cultured. On average, 482 colonies were produced. On average, 119 colonies were produced after cultivation of saliva collected after brushing with regular toothpaste. It became. After brushing, oral bacteria decreased by 75.3% compared with before brushing.

Saliva before brushing Saliva after brushing sample 1-1: 225 sample 1-4: 26 sample 1-2: 330 sample 1-5: 183 sample 1-3: 890 sample 1-6: 147 Average Colony Count: 482 Average Colony Count: 119

The table shows the General Toothpaste experiments-Colony numbers of saliva before and after brushing.

In the experiment (2) with toothpaste containing hemp fibers, the average saliva culture of 290 bacterial colonies was produced, but only 11 colonies were produced in saliva culture after brushing with toothpaste. In other words, the number of colony of oral bacteria was reduced by 96.2% compared to before brushing.

Saliva before brushing  Saliva after brushing sample 2-1: 174 sample 2-4: 11 sample 2-2: 160 sample 2-5: 13 sample 2-3: 538 sample 2-6: 10 Average Colony Count: 290 Average Colony Count: 11

The table above shows Hemp Fiber Toothpaste Experiments-Colony numbers of saliva before and after brushing.

1 is a photomicrograph of crushed hemp fibers (magnification x 50, average thickness 0.41 mm).

2 is a scanning electron microscope (SEM) photograph of the hemp fiber cross section.

Figure 3 is a bacterial culture photograph of the experiment (1) using a general toothpaste.

Figure 4 is a bacterial culture of the experiment (2) using a toothpaste containing hemp fibers

Claims (11)

An antimicrobial toothpaste composition against oral bacteria having a hemp fiber of 100 to 1000 µm in length as an active ingredient. The antimicrobial toothpaste composition according to claim 1, wherein the hemp fiber content is 0.1 to 5% by weight based on the total toothpaste composition. The antimicrobial toothpaste composition according to claim 1 or 2, wherein the hemp fiber has a thickness of 10 to 900 µm. delete delete 3. The antimicrobial toothpaste composition according to claim 1 or 2, wherein the toothpaste composition is a liquid, paste or transparent gel type formulation. delete delete delete delete delete

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