KR100963164B1 - 초임계유체를 이용한 단백질 미세입자화 장치 및 단백질미세입자화 방법 - Google Patents

초임계유체를 이용한 단백질 미세입자화 장치 및 단백질미세입자화 방법 Download PDF

Info

Publication number: KR100963164B1
Authority: KR; South Korea
Prior art keywords: protein; supercritical fluid; protein solution; flow rate; microparticles
Prior art date: 2005-03-22
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.): Expired - Fee Related

Application number

KR1020077023960A

Other languages

English (en)

Korean (ko)

Other versions

KR20080011277A (ko

Inventor

표동진

오달균

Original Assignee

주식회사 리제론

Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)

2005-03-22

Filing date

2006-03-22

Publication date

2010-06-15

2006-03-22 Application filed by 주식회사 리제론 filed Critical 주식회사 리제론

2008-02-01 Publication of KR20080011277A publication Critical patent/KR20080011277A/ko

2010-06-15 Application granted granted Critical

2010-06-15 Publication of KR100963164B1 publication Critical patent/KR100963164B1/ko

Status Expired - Fee Related legal-status Critical Current

2026-03-22 Anticipated expiration legal-status Critical

Images

Classifications

- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/14—Particulate form, e.g. powders, Processes for size reducing of pure drugs or the resulting products, Pure drug nanoparticles
- A61K9/16—Agglomerates; Granulates; Microbeadlets ; Microspheres; Pellets; Solid products obtained by spray drying, spray freeze drying, spray congealing,(multiple) emulsion solvent evaporation or extraction
- A61K9/1682—Processes
- A61K9/1688—Processes resulting in pure drug agglomerate optionally containing up to 5% of excipient
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K38/00—Medicinal preparations containing peptides
- A61K38/16—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- A61K38/17—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
- A61K38/22—Hormones
- A61K38/27—Growth hormone [GH], i.e. somatotropin
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/14—Particulate form, e.g. powders, Processes for size reducing of pure drugs or the resulting products, Pure drug nanoparticles
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P5/00—Drugs for disorders of the endocrine system
- A61P5/10—Drugs for disorders of the endocrine system of the posterior pituitary hormones, e.g. oxytocin, ADH
- B—PERFORMING OPERATIONS; TRANSPORTING
- B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
- B01J—CHEMICAL OR PHYSICAL PROCESSES, e.g. CATALYSIS OR COLLOID CHEMISTRY; THEIR RELEVANT APPARATUS
- B01J19/00—Chemical, physical or physico-chemical processes in general; Their relevant apparatus
- B01J19/26—Nozzle-type reactors, i.e. the distribution of the initial reactants within the reactor is effected by their introduction or injection through nozzles
- B—PERFORMING OPERATIONS; TRANSPORTING
- B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
- B01J—CHEMICAL OR PHYSICAL PROCESSES, e.g. CATALYSIS OR COLLOID CHEMISTRY; THEIR RELEVANT APPARATUS
- B01J2/00—Processes or devices for granulating materials, e.g. fertilisers in general; Rendering particulate materials free flowing in general, e.g. making them hydrophobic
- B01J2/02—Processes or devices for granulating materials, e.g. fertilisers in general; Rendering particulate materials free flowing in general, e.g. making them hydrophobic by dividing the liquid material into drops, e.g. by spraying, and solidifying the drops
- B—PERFORMING OPERATIONS; TRANSPORTING
- B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
- B01J—CHEMICAL OR PHYSICAL PROCESSES, e.g. CATALYSIS OR COLLOID CHEMISTRY; THEIR RELEVANT APPARATUS
- B01J3/00—Processes of utilising sub-atmospheric or super-atmospheric pressure to effect chemical or physical change of matter; Apparatus therefor
- B01J3/008—Processes carried out under supercritical conditions
- B—PERFORMING OPERATIONS; TRANSPORTING
- B05—SPRAYING OR ATOMISING IN GENERAL; APPLYING FLUENT MATERIALS TO SURFACES, IN GENERAL
- B05B—SPRAYING APPARATUS; ATOMISING APPARATUS; NOZZLES
- B05B7/00—Spraying apparatus for discharge of liquids or other fluent materials from two or more sources, e.g. of liquid and air, of powder and gas
- B05B7/02—Spray pistols; Apparatus for discharge
- B05B7/06—Spray pistols; Apparatus for discharge with at least one outlet orifice surrounding another approximately in the same plane
- B05B7/062—Spray pistols; Apparatus for discharge with at least one outlet orifice surrounding another approximately in the same plane with only one liquid outlet and at least one gas outlet
- B05B7/066—Spray pistols; Apparatus for discharge with at least one outlet orifice surrounding another approximately in the same plane with only one liquid outlet and at least one gas outlet with an inner liquid outlet surrounded by at least one annular gas outlet
- B—PERFORMING OPERATIONS; TRANSPORTING
- B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
- B01J—CHEMICAL OR PHYSICAL PROCESSES, e.g. CATALYSIS OR COLLOID CHEMISTRY; THEIR RELEVANT APPARATUS
- B01J2219/00—Chemical, physical or physico-chemical processes in general; Their relevant apparatus
- B01J2219/00002—Chemical plants
- B01J2219/00004—Scale aspects
- B01J2219/00006—Large-scale industrial plants
- Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
- Y02—TECHNOLOGIES OR APPLICATIONS FOR MITIGATION OR ADAPTATION AGAINST CLIMATE CHANGE
- Y02P—CLIMATE CHANGE MITIGATION TECHNOLOGIES IN THE PRODUCTION OR PROCESSING OF GOODS
- Y02P20/00—Technologies relating to chemical industry
- Y02P20/50—Improvements relating to the production of bulk chemicals
- Y02P20/54—Improvements relating to the production of bulk chemicals using solvents, e.g. supercritical solvents or ionic liquids

Landscapes

Health & Medical Sciences (AREA)
Chemical & Material Sciences (AREA)
Life Sciences & Earth Sciences (AREA)
Bioinformatics & Cheminformatics (AREA)
Engineering & Computer Science (AREA)
Medicinal Chemistry (AREA)
Chemical Kinetics & Catalysis (AREA)
Public Health (AREA)
Veterinary Medicine (AREA)
Pharmacology & Pharmacy (AREA)
Organic Chemistry (AREA)
Animal Behavior & Ethology (AREA)
General Health & Medical Sciences (AREA)
Epidemiology (AREA)
Endocrinology (AREA)
Gastroenterology & Hepatology (AREA)
Zoology (AREA)
Immunology (AREA)
Proteomics, Peptides & Aminoacids (AREA)
Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
General Chemical & Material Sciences (AREA)
Diabetes (AREA)
Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
Peptides Or Proteins (AREA)
Medicinal Preparation (AREA)
Nozzles (AREA)
Carbon And Carbon Compounds (AREA)

KR1020077023960A 2005-03-22 2006-03-22 초임계유체를 이용한 단백질 미세입자화 장치 및 단백질미세입자화 방법 Expired - Fee Related KR100963164B1 (ko)

Applications Claiming Priority (4)

Application Number	Priority Date	Filing Date	Title
KR20050023618		2005-03-22
KR1020050023618		2005-03-22
KR20050124456		2005-12-16
KR1020050124456		2005-12-16

Publications (2)

Publication Number	Publication Date
KR20080011277A KR20080011277A (ko)	2008-02-01
KR100963164B1 true KR100963164B1 (ko)	2010-06-15

Family

ID=37023983

Family Applications (1)

Application Number	Title	Priority Date	Filing Date
KR1020077023960A Expired - Fee Related KR100963164B1 (ko)	2005-03-22	2006-03-22	초임계유체를 이용한 단백질 미세입자화 장치 및 단백질미세입자화 방법

Country Status (5)

Country	Link
US (1)	US20090053314A1 (fr)
EP (1)	EP1866407A4 (fr)
JP (1)	JP2008537738A (fr)
KR (1)	KR100963164B1 (fr)
WO (1)	WO2006101352A1 (fr)

Cited By (1)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
KR102154923B1 (ko) *	2019-03-05	2020-09-10	서울대학교산학협력단	배양액의 결정화 및 초임계 건조 장치 및 방법

Families Citing this family (6)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
US20100294986A1 (en) *	2009-05-19	2010-11-25	Massachusetts Institute Of Technology	Supercritical fluid facilitated particle formation in microfluidic systems
EP2298286B8 (fr) *	2009-09-18	2017-08-09	SiTec PharmaBio SL	Procédé de déshydratation de poudres de produit
EP2476476B1 (fr) *	2011-01-14	2018-05-30	General Electric Technology GmbH	Compression d'un fluide contenant du dioxyde de carbone
ES2751337T3 (es)	2012-02-07	2020-03-31	Centre Nat Rech Scient	Procedimiento y dispositivo de preparación de nanopartículas por evaporación súbita
US10822382B2 (en)	2013-08-09	2020-11-03	Regeron, Inc.	Composition for improving skin conditions comprising a fragment of human heat shock protein 90A as an active ingredient
KR102143557B1 (ko)	2013-08-09	2020-08-12	주식회사 리제론	인간 열 활성화 단백질 90a의 절편을 유효성분으로 포함하는 피부상태 개선용 조성물

Citations (2)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
US6063138A (en)	1994-06-30	2000-05-16	Bradford Particle Design Limited	Method and apparatus for the formation of particles
EP0961651B1 (fr) *	1997-02-21	2004-05-12	Nektar Therapeutics UK Limited	Procede et appareil pour la formation de particules

Family Cites Families (3)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
US6051256A (en) *	1994-03-07	2000-04-18	Inhale Therapeutic Systems	Dispersible macromolecule compositions and methods for their preparation and use
US5487965A (en) *	1994-09-06	1996-01-30	Xerox Corporation	Processes for the preparation of developer compositions
GB9915975D0 (en) *	1999-07-07	1999-09-08	Bradford Particle Design Ltd	Method for the formation of particles

2006
- 2006-03-10 EP EP06716500A patent/EP1866407A4/fr not_active Withdrawn
- 2006-03-10 US US11/908,893 patent/US20090053314A1/en not_active Abandoned
- 2006-03-22 KR KR1020077023960A patent/KR100963164B1/ko not_active Expired - Fee Related
- 2006-03-22 JP JP2008502910A patent/JP2008537738A/ja active Pending
- 2006-03-22 WO PCT/KR2006/001051 patent/WO2006101352A1/fr active Application Filing

Patent Citations (2)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
US6063138A (en)	1994-06-30	2000-05-16	Bradford Particle Design Limited	Method and apparatus for the formation of particles
EP0961651B1 (fr) *	1997-02-21	2004-05-12	Nektar Therapeutics UK Limited	Procede et appareil pour la formation de particules

Non-Patent Citations (2)

* Cited by examiner, † Cited by third party
Title
European Journal of Pharmaceutical Sciences (2000) Vol.11, pp 239-245.*
Journal of Supercritical Fluids (2001) Vol.20, pp 179-219.

Cited By (2)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
KR102154923B1 (ko) *	2019-03-05	2020-09-10	서울대학교산학협력단	배양액의 결정화 및 초임계 건조 장치 및 방법
WO2020180106A1 (fr) *	2019-03-05	2020-09-10	서울대학교산학협력단	Appareil et procédé de cristallisation et de séchage supercritique d'une solution de culture

Also Published As

Publication number	Publication date
KR20080011277A (ko)	2008-02-01
US20090053314A1 (en)	2009-02-26
EP1866407A4 (fr)	2010-07-14
JP2008537738A (ja)	2008-09-25
EP1866407A1 (fr)	2007-12-19
WO2006101352A8 (fr)	2008-01-03
WO2006101352A1 (fr)	2006-09-28

Publication	Publication Date	Title
KR100963164B1 (ko)	2010-06-15	초임계유체를 이용한 단백질 미세입자화 장치 및 단백질미세입자화 방법
Bleich et al.	1996	Production of drug loaded microparticles by the use of supercritical gases with the aerosol solvent extraction system (ASES) process
Kankala et al.	2018	Solution-enhanced dispersion by supercritical fluids: an ecofriendly nanonization approach for processing biomaterials and pharmaceutical compounds
RU2224538C2 (ru)	2004-02-27	Фармацевтические композиции, предназначенные для пролонгированного высвобождения пептидов, и способ их приготовления
Wang et al.	2006	The application of a supercritical antisolvent process for sustained drug delivery
US20100308483A1 (en)	2010-12-09	Process and Arrangement for Producing Particles Utilizing Subcritical Fluids
CN102458371A (zh)	2012-05-16	具有确定异构体含量的二酮哌嗪微粒
CA2353809A1 (fr)	2000-06-15	Systemes noyau-coque nanoparticulaires et leur utilisation dans des preparations pharmaceutiques et cosmetiques
KR100853596B1 (ko)	2008-08-22	방법
CN108578372A (zh)	2018-09-28	微晶二酮哌嗪组合物以及方法
KR20090077066A (ko)	2009-07-14	입자 형성
ES2616872T3 (es)	2017-06-14	Método para preparar partículas a escala nanométrica o amorfas usando grasa sólida como solvente
Hong et al.	2018	Preparation of micrometric powders of parathyroid hormone (PTH1–34)-loaded chitosan oligosaccharide by supercritical fluid assisted atomization
CN104546728A (zh)	2015-04-29	一种疏水药物的纳米晶、制备及使用方法
US20140086994A1 (en)	2014-03-27	Synthesis of Small Particles
CN111643459B (zh)	2022-08-09	一种白藜芦醇颗粒及其制备方法
WO2016123973A1 (fr)	2016-08-11	Procédé de préparation d'une préparation d'itraconazole
CN101785867B (zh)	2011-11-16	玉米蛋白纳米颗粒的制备方法
US7186796B2 (en)	2007-03-06	Method for drying water-borne materials
CN105748413B (zh)	2018-06-29	羟基喜树碱纳米晶体负载微球及其制备方法
EP1339391A1 (fr)	2003-09-03	Synthese de petites particules
JP2020523407A (ja)	2020-08-06	非晶質ナノ構造医薬材料
Pyo	2009	Two different shapes of insulin microparticles produced by solution enhanced dispersion supercritical fluid (SEDS) process
CN101773473A (zh)	2010-07-14	一种纳米化胰岛素粉体的超临界反溶剂制备方法
KR101359581B1 (ko)	2014-02-25	초임계 유체와 반용매를 이용한 천연 추출물의 수용성 미립자 제조 방법

Legal Events

Date	Code	Title	Description
2007-10-18	A201	Request for examination
2007-10-18	PA0105	International application	Patent event date: 20071018 Patent event code: PA01051R01D Comment text: International Patent Application
2007-10-18	PA0201	Request for examination
2008-02-01	PG1501	Laying open of application
2009-06-15	E902	Notification of reason for refusal
2009-06-15	PE0902	Notice of grounds for rejection	Comment text: Notification of reason for refusal Patent event date: 20090615 Patent event code: PE09021S01D
2010-03-12	E701	Decision to grant or registration of patent right
2010-03-12	PE0701	Decision of registration	Patent event code: PE07011S01D Comment text: Decision to Grant Registration Patent event date: 20100312
2010-06-04	GRNT	Written decision to grant
2010-06-04	PR0701	Registration of establishment	Comment text: Registration of Establishment Patent event date: 20100604 Patent event code: PR07011E01D
2010-06-04	PR1002	Payment of registration fee	Payment date: 20100607 End annual number: 3 Start annual number: 1
2010-06-15	PG1601	Publication of registration
2013-06-04	FPAY	Annual fee payment	Payment date: 20130604 Year of fee payment: 4
2013-06-04	PR1001	Payment of annual fee	Payment date: 20130604 Start annual number: 4 End annual number: 4
2014-06-02	FPAY	Annual fee payment	Payment date: 20140602 Year of fee payment: 5
2014-06-02	PR1001	Payment of annual fee	Payment date: 20140602 Start annual number: 5 End annual number: 5
2015-06-02	FPAY	Annual fee payment	Payment date: 20150603 Year of fee payment: 6
2015-06-02	PR1001	Payment of annual fee	Payment date: 20150603 Start annual number: 6 End annual number: 6
2016-06-07	FPAY	Annual fee payment	Payment date: 20160607 Year of fee payment: 7
2016-06-07	PR1001	Payment of annual fee	Payment date: 20160607 Start annual number: 7 End annual number: 7
2017-06-05	FPAY	Annual fee payment	Payment date: 20170605 Year of fee payment: 8
2017-06-05	PR1001	Payment of annual fee	Payment date: 20170605 Start annual number: 8 End annual number: 8
2018-06-04	FPAY	Annual fee payment	Payment date: 20180604 Year of fee payment: 9
2018-06-04	PR1001	Payment of annual fee	Payment date: 20180604 Start annual number: 9 End annual number: 9
2019-06-04	FPAY	Annual fee payment	Payment date: 20190604 Year of fee payment: 10
2019-06-04	PR1001	Payment of annual fee	Payment date: 20190604 Start annual number: 10 End annual number: 10
2020-06-03	PR1001	Payment of annual fee	Payment date: 20200603 Start annual number: 11 End annual number: 11
2022-06-05	PC1903	Unpaid annual fee	Termination category: Default of registration fee Termination date: 20230315