KR100659902B1 - On-site diagnosis device - Google Patents

Abstract

An on-site diagnosis apparatus according to the present invention includes: an operation unit including a plurality of numeric keys and predetermined function keys, for generating key data by a user's operation; A reagent tray in which a sample kit from which a test sample of a subject is collected is set; A vision camera unit which outputs image data by capturing the diagnostic sample with one image grab; A control unit generating control signals according to the key data and the control program, quantitatively analyzing the image data, and outputting a diagnosis result; And a storage unit for storing and reading image data, temporary data generated during a diagnosis process, a diagnosis result, and a control program according to a control signal.

According to the field diagnosis apparatus according to the present invention, since the image of the sample is taken by the vision camera, the measurement can be performed quickly even with a single image grab. Therefore, the on-site diagnosis time is shortened.

Description

Point of care test apparatus

1 is a block diagram for explaining the configuration of the on-site diagnostic apparatus according to an embodiment of the present invention.

2 is an example of the actual configuration of the field diagnosis apparatus shown in FIG.

3 is a block diagram of a preferred embodiment of the sample kit photographing surface of the vision camera shown in FIG.

4 is a view showing a state in which the reagent tray is inserted through the lower end of the vision camera.

5 is a block diagram of another preferred embodiment of the reagent tray shown in FIG.

6 illustrates a state in which a sub tray is mounted in the reagent tray body of FIG. 5.

FIG. 7 illustrates a reagent tray having a sub tray mounted on the reagent tray main body of FIG. 5 and a sample kit mounted on the sub tray.

8 is a view showing an example of a typical single window type sample kit.

9 is a flowchart for explaining a position deviation compensation and inspection method of the test sample performed by the field diagnosis apparatus of the present invention.

The present invention relates to a point of care test (POCT) device.

On-site diagnosis refers to a test that can be used for diagnosis and treatment by conducting promptly near the subject without pretreatment such as centrifugation.

On-site diagnostics can be used anywhere, at home, at work, at a hospital, at a sports center, in an ambulance or at a battlefield.

In addition, the on-site diagnosis device can immediately check the test results, and the results of the test can be seen quickly even with a small sample amount, thereby increasing the satisfaction of the test subject.

These on-site diagnostic devices are emerging as an alternative to reduce the financial burden on the clinical facilities of hospitals, and are being used as health equipment for disease prevention of individuals and households.

Conventional field diagnosis equipment uses a laser diode as an illumination light source to irradiate light of a specific wavelength to a POCT kit, and analyze the reaction result by detecting light reflected on a sample by using a photo multiplier tube (PMT) device or a photodiode. do.

The conventional on-site diagnostic equipment has a problem that the measurement takes a long time and a large measurement error according to the positional deviation of the sample kit because it is measured by sequentially scanning the entire measurement area of the sample.

SUMMARY OF THE INVENTION The present invention has been made in an effort to provide an on-site diagnostic apparatus which shortens measurement time and improves measurement errors.

Field diagnosis apparatus according to the present invention for achieving the above technical problem, comprising a plurality of numeric keys and predetermined function keys, the operation unit for generating key data by the user's operation; A reagent tray in which a sample kit from which a test sample of a subject is collected is set; A vision camera unit for photographing the diagnostic sample with one image grab and outputting image data; A control unit generating control signals according to the key data and the control program, and analyzing the image data to output a diagnosis result; A storage unit for storing and reading the image data, temporary data generated in the process of analyzing the image data, the diagnosis result, and the control program according to the control signal; And a display unit for displaying a diagnosis process and the diagnosis result.

The on-site diagnostic device may further include a barcode scanner for inputting barcode information of the sample kit.

The field diagnosis apparatus may further include a printer that prints the diagnosis result on a print sheet in response to the control signal.

The vision camera unit CCD camera; And a lighting unit provided with a plurality of white LEDs spaced a predetermined distance from the periphery of the CCD camera.

The reagent tray is preferably provided with a receiving portion so that the sample kit is set in the form of a cartridge.

The field diagnosis device may further include an interface unit for transmitting the diagnosis result to the outside.

Hereinafter, with reference to the accompanying drawings the configuration and operation of the on-site diagnostic apparatus according to a preferred embodiment of the present invention will be described in detail as follows. Like reference numerals in the drawings denote components that perform the same function.

1 is a block diagram of an on-site diagnostic apparatus according to a preferred embodiment of the present invention, which includes a main body 100, a vision camera unit 102, and a reagent tray 104.

The reagent tray 104 is set with a sample kit from which a test sample is collected.

The vision camera unit 102 outputs image data by capturing the diagnostic sample in one image grab.

The main body 100 includes an operation unit 106, a control unit 108, a storage unit 110, and a display unit 112.

The operation unit 106 includes a plurality of numeric keys and predetermined function keys to generate key data by user's operation.

The controller 108 generates control signals according to the key data and the control program, analyzes the image data, and outputs a diagnosis result. The controller 250 outputs control signals for overall control of the data transmission and reception apparatus according to a predetermined control program. Each part of the data transmission / reception apparatus operates in response to a control signal input to them.

The storage unit 110 stores and reads the image data, the temporary data generated in the process of analyzing the image data, and the diagnosis result according to the control signal. In addition, the storage unit 110 stores a control program executed when the control unit 108 controls the field diagnosis apparatus of the present invention.

The control unit 108 and the storage unit 110 may be provided as a single chip (one chip).

The display unit 112 displays a diagnosis process and a diagnosis result. The display unit 112 may be implemented by a liquid crystal display (LCD). The display unit 112 may display contents of data stored in the storage unit 110 to allow a user to confirm.

Each component of the above-mentioned on-site diagnosis apparatus exchanges data by a bus 114 provided by signal lines, cables, and the like of a printed circuit board.

The interface unit 116 interfaces data IN / OUT between an on-site diagnosis device and an external device such as a computer (not shown). The measured diagnostic result may be transmitted to the external device through the interface unit 116 and utilized. The interface unit 116 may be implemented by a serial interface, a parallel interface, a wireless LAN interface, or the like.

The on-site diagnosis apparatus according to the present invention may further include a printer 116 for printing a diagnosis result on a print sheet in response to a control signal. The printer 116 may be provided, for example, as a thermal printer. The printer 116 may be coupled to the main body 100 of the field diagnosis apparatus as shown in FIG. 2, or may be provided separately from the main body 100 by a predetermined printer interface.

The on-site diagnosis apparatus according to the present invention may further include a barcode scanner 118 capable of inputting an operator, an examinee, information of a sample, etc. as a barcode.

2 is an example of the actual configuration of the field diagnosis apparatus shown in FIG.

The reagent tray 104 may be attached to or detached from the vision camera 102 through the lower end of the vision camera 102.

The main body 100 includes components such as a control unit (not shown) and a storage unit (not shown), and includes a display unit 112 and an operation unit 106.

The printer 116 is provided in a form coupled to the main body 100.

In addition, the field diagnosis apparatus of the present invention may be implemented to automatically power off when not used for a predetermined period. To this end, the field diagnosis apparatus of the present invention includes a timer (not shown), and the controller 108 automatically determines the field diagnosis apparatus when it is determined that a predetermined time has elapsed since the field diagnosis apparatus was last used by using the timer. The control operation may be performed to power off.

In FIG. 2, the power adapter 122 converts AC into direct current and supplies power to the main body 100 of the on-site diagnosis apparatus. The power adapter 122 may be replaced by a battery pack (not shown) or the like.

3 is a configuration diagram of a preferred embodiment of the sample kit photographing surface of the vision camera 102 shown in FIG. 2, which includes a CCD camera 126 and an illumination unit 124.

The CCD camera 126 photographs the diagnostic sample in one image grab. The CCD camera 126 includes a lens unit 128, a charge coupled device (CCD) light receiving device, a photoelectric conversion device, a digital signal processor (DSP), and the like, to capture a diagnostic sample in one image grab.

The lighting unit 124 is spaced a predetermined distance around the CCD camera 126 is provided with a plurality of white light emitting diodes (LEDs). Referring to FIG. 3, it can be seen that six white LEDs 124 are installed around the lens unit 128 of the CCD camera 126. Six white LEDs 124 may be provided in a predetermined number in an area capable of uniformly illuminating the sample kit 130 shown in FIG. 4.

The on-site diagnostic apparatus according to the present invention can simultaneously process the inspection results of a wide light wavelength band by using a white LED light source as illumination.

4 illustrates a state in which the reagent tray 104 in which the sample kit 130 is mounted is inserted through the lower end of the vision camera 102.

Referring to FIG. 4, a sample kit 130 in which a test sample of a test subject is collected is set in a reagent tray 104. In the present invention, the reagent tray 104 is provided with a receiver such that the sample kit 130 is set in the form of a cartridge.

In the present invention, the sample kit accommodating portion of the reagent tray 104 may be formed in various shapes and sizes.

5 is a block diagram of another preferred embodiment of the reagent tray 104, which includes a tray body 134 and a sub tray 136. As shown in FIG.

The tray main body 134 is provided with a receiving portion 134a on which the sub tray 136 is mounted. An accommodating part 138 may be formed inside the sub tray 136 to accommodate the sample kit 130 having a predetermined size. At this time, by designing a variety of sizes of the receiving portion 138 of the sub tray 136 can correspond to the sample kit 130 of various sizes.

6 illustrates a state in which the sub tray 136 is mounted on the reagent tray body 134 of FIG. 5. The outer periphery of the receiving portion 134a to which the sub tray 136 and the reagent trap main body 134 are coupled is identically designed, and only the receiving portion 138 of the sub tray 136 is variously designed, thereby making the sample kit of various sizes 130 may correspond. FIG. 7 illustrates a reagent tray 104 having a sub tray 136 mounted on the reagent tray main body 134 of FIG. 5 and a sample kit mounted on the sub tray 130.

8 is a diagram illustrating an example of a typical single window type sample kit.

The sample kit 130 has a window 140 formed at the center thereof, and a predetermined number of six sample strips are fixed inside the window 140. 8 is an example of a sample kit in which three sample strips 146, 144, 142, including the baseline 142, are fixed.

When a sample such as blood is collected in the sample container 148, the sample is absorbed to the window 140 by chromatography and reacts with the sample strips 146, 144, and 142. The color will change. The color of the strip changes with the concentration of the analyte in the sample. Here, the top sample strip 142 becomes a control line, which is present in every sample kit.

In the conventional on-site diagnostic apparatus, a measurement error occurs due to the positional deviation of the test sample. In the present invention, the measurement error can be improved by compensating for the positional deviation of the test sample by the window 140 and the reference line 142.

9 is a flowchart for explaining a position deviation compensation and inspection method of the test sample performed by the field diagnosis apparatus of the present invention.

First, standard information of the window edge of the sample kit (140 of FIG. 8) and the position of the reagent strip (142, 144, and 146 of FIG. 8) is input (S100). The input of the standard information may be input by the user through the operation unit 106 of FIG. 2 or through the barcode scanner 118 of FIG. 2.

The reagent tray equipped with the sample kit (104 in FIG. 2) is inserted into the vision camera (102 in FIG. 2), and an image of the sample kit is obtained (S102).

The window edge of the sample kit and the baseline edge of the reagent strip are detected from the acquired image (S104).

The error is compensated by comparing the standard information of the window edge with the detected information (S106).

Comparing the detected information with the standard information of the baseline edge of the reagent strip to compensate for the position error of the reagent strip (S108).

The two-dimensional image of the window is converted into one-dimensional luminance data in a direction perpendicular to the reagent strip (S110). One-dimensional luminance data consists of the sum of pixel line values in the strip direction. The peak value is extracted from this one-dimensional luminance data.

The peak value of the 1D luminance data is converted into the concentration of the analyte (S112).

By the position deviation compensation method of FIG. 9, measurement errors due to manufacturing tolerances of the sample kit 130 itself and tolerances when the sample tray 104 is inserted into the vision camera 102 may be compensated.

The best embodiments have been disclosed in the drawings and specification above. Although specific terms have been used herein, they are used only for the purpose of describing the present invention and are not used to limit the scope of the present invention as defined in the meaning or claims. Therefore, those skilled in the art will understand that various modifications and equivalent other embodiments are possible from this. Therefore, the true technical protection scope of the present invention will be defined by the technical spirit of the appended claims.

As described above, according to the on-site diagnostic apparatus of the present invention has the following effects.

First, since the image of the sample is taken by a vision camera, the measurement can be performed quickly with one image grab. Therefore, the on-site diagnosis time is shortened.

Second, by using a white LED light source as illumination, it is possible to simultaneously process the inspection results of a wide wavelength range.

Third, the measurement error can be improved by compensating for the positional deviation of the test sample by using a vision processing algorithm.

Fourth, it is possible to respond to a variety of sample kits by having a variety of design of the receiving portion of the sample kit of the reagent tray.

The invention is not limited to the examples described above and represented in the drawings. Those skilled in the art taught by the above-described embodiments, many modifications to the above-described embodiments are possible by substitution, erasure, merging, etc. within the scope and object of the present invention described in the following claims.

Claims (10)

An operation unit for generating key data instructing on-site diagnosis by a user's operation; A reagent tray in which a sample kit from which a test sample of a subject is collected is set; A vision camera unit including a receiving unit to which the reagent tray is detachable, and outputting image data by capturing the diagnostic sample collected in the sample kit with one image grab while the reagent tray is inserted into the receiving unit; A control unit generating control signals according to the key data and the control program, and analyzing the image data to output a diagnosis result; A storage unit for storing and reading the image data, temporary data generated in the process of analyzing the image data, and the diagnosis result according to the control signal; And An on-site diagnosis apparatus comprising a display unit for displaying a diagnosis process and the diagnosis result. An operation unit for generating key data instructing on-site diagnosis by a user's operation; A reagent tray in which a sample kit from which a test sample of a subject is collected is set; A vision camera unit for photographing the diagnostic sample with one image grab and outputting image data; A control unit generating control signals according to the key data and the control program, and analyzing the image data to output a diagnosis result; A storage unit for storing and reading the image data, temporary data generated in the process of analyzing the image data, and the diagnosis result according to the control signal; A display unit displaying a diagnosis process and the diagnosis result; And And a bar code scanner for inputting bar code information of the sample kit. The method according to claim 1 or 2, And a printer for printing the diagnosis result on a print sheet in response to the control signal. According to claim 1 or claim 2, wherein the vision camera unit A CCD camera for photographing the diagnostic sample with one image grab; And On-site diagnostic apparatus characterized in that it comprises a lighting unit is provided with a plurality of white LEDs spaced at a predetermined interval around the CCD camera. An operation unit for generating key data instructing on-site diagnosis by a user's operation; A reagent tray in which a sample kit from which a test sample of a subject is collected is set; A vision camera unit for photographing the diagnostic sample with one image grab and outputting image data; A control unit generating control signals according to the key data and the control program, and analyzing the image data to output a diagnosis result; A storage unit for storing and reading the image data, temporary data generated in the process of analyzing the image data, and the diagnosis result according to the control signal; And A display unit for displaying a diagnosis process and the diagnosis result, The reagent tray may include a sub tray having a receiving part for accommodating the sample kit; And a tray main body on which the sub tray is mounted. The method according to any one of claims 1, 2 and 5, On-site diagnostic apparatus further comprises an interface unit for transmitting the diagnosis result to the outside. The method of claim 5, wherein the sub tray is On-site diagnostics, characterized in that it is designed in a variety of forms to accommodate a variety of sample kits. The method of claim 1, On-site diagnostic apparatus further comprising a barcode scanner for inputting the barcode information of the sample kit. The method of claim 1 or 5, wherein the control unit Receive standard information of the window edge and the reagent strip of the sample kit through the operation unit, Obtaining an image of the sample kit taken by the vision camera, Detecting the window edge of the sample kit and the baseline edge of the reagent strip from the acquired image, Compensating for the error by comparing the standard information of the window edge and the detected information, Compensating for the error by comparing the detected information with the standard information of the baseline edge of the reagent strip, Converts a two-dimensional image of the window into one-dimensional luminance data in a direction perpendicular to the reagent strip, By converting the one-dimensional luminance data into a concentration to complete the inspection, On-site diagnostic apparatus, characterized in that for inspecting the sample to compensate for the measurement error. The method of claim 2 or 8, wherein the control unit Receive standard information of the window edge of the sample kit and the reagent strip through the operation unit or the barcode scanner, Acquire an image of the sample kit taken by the vision camera, Detecting the window edge of the sample kit and the baseline edge of the reagent strip from the acquired image, Compensating for the error by comparing the standard information of the window edge and the detected information, Compensating for the error by comparing the detected information with the standard information of the baseline edge of the reagent strip, Converts a two-dimensional image of the window into one-dimensional luminance data in a direction perpendicular to the reagent strip, By converting the one-dimensional luminance data into a concentration to complete the inspection, On-site diagnostic apparatus, characterized in that for inspecting the sample to compensate for the measurement error.

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