KR100514132B1 - Composition and kit for losing body weight - Google Patents

Abstract

The present invention relates to a herbal composition for weight loss and a kit comprising the same, wherein the herbal composition for weight loss according to the present invention includes ephedra of weight loss function, herbal mixture for enhancing digestion, herbal mixture for antioxidant function, schisandra chinensis and licorice It includes, the herbal mixture for enhancing digestive function is composed of creation, hawthorn, taxa and deficiency, the herbal mixture of the antioxidant function, consists of the upper leaf, lump, Salvia and goji, the ephedra is the adult standard of ephedrine 1 It contains a daily unit dose of 0.22 to 0.44 mg, the creation is 15 to 19% by weight, the mountain sand, tack and wolfberry are 9 to 13% by weight, respectively, lumps, upper leaves, gyeoljak and dansam 7 to 11 It is characterized by containing 2% by weight to 6% by weight, Schisandra chinensis and Licorice.

 The herbal composition and kit for weight loss according to the present invention may provide a composition which exhibits a sufficient weight loss effect while preventing side effects due to the administration of ephedrine by containing ephedra at a certain concentration. In addition to the weight control effect, considering the peculiar constitution of Asians, it promotes digestion, removes stool, and facilitates bowel movement. In addition, there is an effect of preventing aging due to weight loss to strengthen skin elasticity and reduce wrinkles.

Description

Herbal composition for weight loss and weight loss kit comprising the same {Composition and kit for losing body weight}

The present invention relates to a composition for weight loss. More particularly, the present invention relates to a weight loss composition containing ephedra.

In modern times, obesity is rampant not only in the West, such as the United States, but also in the East, including Korea. This seems to be due to increased preference for Western diet. Accordingly, the obese body shape that was previously seen only in the West is often observed in the East. This is especially true for children, so the problem of obesity will be highlighted throughout the 21st century.

Obesity can be defined as the accumulation of excess fat in the body. This over-accumulation of fat can occur as a result of more energy reception than energy consumption, caused by excessive energy consumption (eg, excess food) or reduced energy consumption. Obesity can be classified as mild (20-30% overweight), moderate (30-60% overweight), or severe (60% overweight). Obesity can harm your health in many ways. Obesity can damage both heart and lung function, disrupt endocrine function and cause mental problems. Hypertension, impaired glucose tolerance and non-insulin dependent diabetes mellitus and hypercholesterolemia are more common symptoms in overweight people than in normal weight. Obesity can therefore contribute to the morbidity and mortality of people suffering from diseases such as hypertension, seizures, diabetes type II, certain types of cancer, gallbladder disease and ischemic heart disease. Moderate and severe obesity cases are known to increase mortality. Colon and rectal cancer is a common disease in obese men and women who often have endometrial or gallbladder cancer. It is also recognized that an increase in overweight almost eventually causes mental and social problems.

In addition to the above health reasons, obesity is of particular interest in terms of beauty, especially in younger age groups. In terms of health, even if he appears to be extremely normal, not obese, he thinks he is fat and needs to become thinner. In particular, the trend toward body lines, rather than just weight loss, was prominent. Due to this necessity, obesity-related industries are gradually developed, forming a huge market. Accordingly, the number of similar drugs or health foods that have not undergone medical verification is also increasing exponentially. The damages caused by unprofessional treatment and unreasonable diet attempts by people who are not medically similar or not in the medical profession are constantly reported. Excessive diet is dangerous enough to cause life. For example, diet causing excessive body fluid loss, taking diuretic ingredients that cause persistent diarrhea, and injecting growth hormone may be harmful to life.

The non-medical diet method containing the above problems may show the effect of rapid weight loss on the surface, but in proportion to this may adversely affect health.

On the other hand, some weight loss drug ingredients that have been previously proved medically effective and stable have recently been known to cause fatal side effects, the use of the regulation is being made. Among them, ephedrine is an irritant that activates nerve and heart activity, and it has been reported that it may cause side effects such as heart attack, seizures and mood swings, delusions, insomnia, palpitations, and headaches. However, a safe dosage range for preventing the side effects is not known yet. In particular, it is not known in detail how much amount to use a safe and weight control effect without the side effects.

Therefore, attention has been focused on determining the safe and effective amount of some weight-reducing components for which side effects are known, while reducing macular degeneration by non-medical diet. Asians, including Koreans, tend to be less digestible than Westerners. Therefore, it is necessary to prescribe according to the constitution of Asians to be well digested. In addition, there is an urgent need to identify a daily dosage range that can maintain the effects of weight control while eliminating the side effects of ephedrine. In addition, as the weight is reduced, the problem that the skin elasticity is reduced and aging is accelerated to increase wrinkles have been pointed out. Therefore, there is an urgent need for measures to prevent aging while losing weight.

The present invention is to solve the above problems, it is an object of the present invention to reveal the effective range of ephedrine that shows a safe and weight loss effect. In addition, it is an object of the present invention to improve the digestion in consideration of the constitution unique to Asians and to provide a weight loss composition that can prevent aging due to weight loss.

In order to achieve the above object, the herbal composition for weight loss according to the present invention includes ephedra of weight loss function, herbal mixture for enhancing digestion function, herbal mixture for antioxidant function, Schisandra chinensis and licorice, Dragon Herbal Mixture consists of Creation, Sansa, Taxa, and Cassiae.The herbal mixture of antioxidant function is composed of upper leaves, lumps, Salvia, and Goji, and the ephedra has an adult daily dose of 0.22 to 0.44 mg of ephedrine. It is contained in such a content, the creation is 15 to 19% by weight, the hawthorn, tactile and goji berry each 9 to 13% by weight, lumps, upper leaves, gyeoljaja and sweet ginseng 7 to 11% by weight, respectively, Schisandra chinensis and licorice It is characterized by containing in an amount of 2 to 6% by weight.

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On the other hand, the herbal composition for weight loss according to the present invention is characterized in that it contains 0.016 to 0.144% by weight of ephedrine in the total composition based on the active ingredient in the total composition.

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Containing the ephedrine is preferably achieved by containing 4 to 8% by weight of ephedra based on the active ingredient in the total composition.

The composition is in liquid form, which is an herbal dry mixture or an aqueous extract of the herbal dry mixture.

In addition, the kit for weight loss according to the present invention is characterized in that it comprises a composition of the liquid form which is an aqueous solution extract of the above-described herbal medicine dry mixture or herbal medicine dry mixture.

The weight loss kit is based on the active ingredients, except for excipients, 15 to 19% by weight, 9 to 13% by weight of hawthorn, talc and wolfberry, respectively, 7 to 11% by weight of lump, upper lobe, deficiency and Salvia is characterized in that it further comprises a yoyo phenomenon prevention pill containing 2 to 6% by weight of Schisandra chinensis and licorice as an active ingredient.

The yo-yo phenomenon prevention pill is characterized in that after taking all of the herbal composition for weight loss.

Hereinafter, the composition and kit according to the present invention will be described in more detail.

The ephedra is preferably 4 to 8% by weight of the total active ingredient, most preferably 6% by weight. When the content of ephedra is less than 4% by weight, the content of ephedrine contained in ephedra is less than 0.016% by weight, and it is difficult to achieve a sufficient weight loss effect with this content of ephedrine. On the other hand, when the content of ephedra exceeds 8% by weight, the content of ephedrine contained in the ephedra exceeds 0.144% by weight, which may cause serious side effects such as hypertension or heart disease. The most preferable content of ephedra in this respect is 6% by weight.

On the other hand, the creation is preferably contained 15 to 19% by weight of the total active ingredient, the most preferable content is 17% by weight. If the content of generation is less than 15% by weight, the effect of enhancing digestion is insignificant, and if it exceeds 19% by weight, there is an imbalance in harmony with other herbal ingredients. The most preferable content in this respect is 17 weight%.

On the other hand, it is preferable to contain 9 to 13% by weight of the hawthorn, tack and wolfberry each of the total active ingredients. The most preferable amount is 11 weight%. When the content is less than 9% by weight, the effect of each component is insignificant, and when the content is more than 13% by weight causes problems in coordination between drugs and drug stability. The most preferable content in this respect is 11 weight%.

In addition, it is preferable to contain 7 to 11 weight% of total block of active ingredients, agglomerate, an upper lobe, a deficiency, and sweet ginseng, and the most preferable content is 9 weight%. If it is less than 7% by weight, the effect is insignificant, and if it exceeds 11% by weight, an imbalance between drugs is caused. It is most preferable to contain 9 weight% from such a viewpoint.

On the other hand, Schisandra chinensis and licorice preferably contain 2 to 6% by weight, and most preferably 4% by weight of the total active ingredients. If less than 2% by weight, the effect of reducing the bitter taste and toxicity of the Chinese medicine is insignificant, and when it exceeds 6% by weight may inhibit the function of other active ingredients. In this respect, the most preferable content is 4% by weight.

In the present invention, the principle of preventing the yo-yo phenomenon is that the rate of absorption of the drug in the body is in the order of decoction (pill)> pill (pill). Is replaced with a more gentle pill to slowly eliminate the dependency on the drug.

In the present invention, Ephedrae herba has a strong fatty acid action and suppresses appetite by making you feel full even with a smaller amount than a conventional meal. Ephedra refers to the stem of Ephedra sinica Stapf. Sometimes it also refers to the stem of Ephedra equisetina BUNGE. Ephedra contains 1-2% of alkaloids, of which ephedrine accounts for 40-90%. Ephedrine has a strong fatty acid action, thereby reducing weight. Ephedrine is present in the order of l-ephedrine, d- pseudoephedrine, d-norsudoephedrine, l-methylephedrine. Ephedrine has a diuretic effect, weight loss action, but also vasoconstrictive action has an adverse effect of raising blood pressure and exciting the central nervous system. Therefore, it is necessary to determine the optimal concentration range that can maintain the weight loss effect while eliminating these side effects. The present inventors found that when the amount of ephedrine ingested per day is 0.22 to 0.44 mg, the weight loss effect may be excellent but the above side effects may not be exhibited. If the daily intake is less than 0.22mg weight loss effect is insignificant, if it exceeds 0.44mg there is a risk of such side effects. Such an optimal ephedrine content range can be achieved when the concentration of ephedra per day is in the range of 2.33 g to 4.67 g.

Morion folium is an element that exhibits antioxidant activity in the composition according to the present invention. The upper leaves refer to the leaves of the Morus genus mulberry. In particular, it refers to the leaves of the leaves of Morus alba LINNE, Morus bombycis KOIDZ, Morus bombycis KOIDZ for. Dissecta NAKAI. The upper lobe is used to remove fever, headaches, and eye redness, and when the sea water is used as lung fever. It also reduces the hives of the skin. The upper lobe contains rutin, quercetin, isoquercitrin, moracetin, quercetin-3-triglucoside, inosterone and exosterone (ecdysterone) and the like. In particular, it contains a large amount of rutin, which is a species of flavonoids has the effect of inhibiting aging by promoting the absorption of vitamin C that is not synthesized in the human body. The routine is 2-phenyl-3,5,7,3 ', 4'-pentahydroxy benzopyrone. This will help prevent wrinkles on your skin as you lose weight. In addition, there is a function to control the diet is not excessive, weight loss is also effective.

Creation (Atractylodis rhizoma) is to enhance the digestive function in the composition according to the invention to absorb the components necessary for the human body after meals and to function as a waste to excrete quickly urine. Creation is the root stem of the Atractylodes japonica KOIDZ of the Asteraceae. Creation removes moisture that has stagnated in the digestive tract and exhibits a sensational action, making it an excellent response to swelling or nausea, vomiting, thin stools, and drowsiness and thick tongues. In particular, it is widely used for symptoms such as summer diarrhea, childhood abdominal diarrhea, reduced food, excessive stomach acid, stomach, duodenal ulcer. Generating contains 5 to 9% of essential oils, the main component of which is hesinsol of sesquiterpene, which accounts for about 55.7% by weight of essential oils. In addition, it contains atractylon, atractylol, vitamins A, B, β-eudesmol, elemol and the like.

Taxi (Alismatis rhizoma) serves to help the creation in the composition according to the invention to promote digestion. Taxi is a tuber of Alisma canaliculatum A. BR. Et BOUCHE, Alisma plantago-aquatica LINNE var. Orientale SAMUELS. Taxa contains many kinds of triterpenoid compounds. In particular, it contains components such as alisol AB, alisol A monoacetate, epialsol A and the like.

Sansa (Crataegii fructus) serves to enhance the digestive function with the creation in the composition according to the invention. The hawthorn is the fruit of the Rosaceae Larch hawthorn ( crataegus pinnatifida BUNGE), the narrow hawthorn ( Crataegus pinnatifida BUNGE var. Psilosa CK SCHNEID.), And the broad-leaved hawthorn ( Crataegus pinnatifida BUNGE var. Major NEBR.) to be. Sansa has a healthy and digestive action, and excellent response to indigestion, carnivorous digestive disorders, abdominal pain. Therefore, it is possible to solve the problem of digestion in the treatment of obesity. In addition, there is a significant effect in preventing the absorption of cholesterol and enhancing the digestion of fatty and animal fat foods. Therefore, it is effective in treating obesity. Sansa contains flavonoid compounds, organic acids, sugars, and vitamin C. In particular, it contains flavonoid compounds, such as hyperoside, quercetin, anthocyanidin, oleanolic acid, tartaric acid, citric acid, cratesgolic acid, and ursolic acid.

Sophorae flos has antioxidant activity with the upper lobe in the composition according to the present invention. Honeysuckle is a bud of Sophora japonica LINNE. Necrosis acts to lower the liver, arteries, and blood cholesterol levels, and has a mild lowering action. Aggregation also contains large amounts of rutin. In particular, flower sake contains 28%, and after flowering, it contains about 10%. Therefore, it is desirable to use before flowering. Rutin has the effect of inhibiting aging by promoting the absorption of vitamin C that is not synthesized in the human body. This will help prevent wrinkles on your skin as you lose weight. In addition, the weight of the diet is not an excessive diet, and the effect of weight loss. Aggregation contains 0.4% triterpene-based saponins, and hydrolysis can yield betulin, sophoradiol, glucose, and glucuronic acid. In buds, Sophorin A 14%, Sophorin B 1.25%, and Sophorin C 0.35% can be obtained. Sophorin A is a flavonoid different from rutin, and B and C are sterols. It also contains tannins, and 0.66% of the fresh flowers.

Salviae (Salviae miltiorrhizae radix) is an antioxidative substance in the composition according to the present invention, and also serves to suppress the side effects of ephedra. Dansam contains a large amount of tanshinone, which has strong antioxidant activity. Dansam soothes the heart, so it is effective for insomnia and palpitations that are hard to sleep and sleepless. Salvia has coronary artery dilation, which significantly increases blood flow and activates lipid metabolism to strengthen cholesterol. Salvia is the root of Saliva miltiorrhiza BUNGE. Dansamon contains tanshinone I, tanshinone IIA, tanshinone IIB, kryptontansinone and isotansinone.

Cassiae semen plays a role in promoting the digestive function with the production or hawthorn in the composition according to the present invention. Among them, there is a diuretic effect and the action to see the stool well, in particular, the action of dilute stool thinning has a great effect on the removal of stool, so it is very helpful for health and also plays a role in weight control. In addition, cholesterol lowering has an inhibitory effect on the formation of atherosclerosis. Cassia is the seed of the Casssia tora LINNE, a legume annual. The deficiency contains components such as chrysopanol, emodin, aloe-emodin, lanes, physcion, obusutin and the like.

Licorice (Glycyrrhizae radix) serves to harmonize other medicines in the composition according to the present invention and exhibit detoxification to the human body. Licorice is the root of the legume perennial licorice ( Glycyrrhiza uralensis FISCH.) And Glycyrrhiza inflata BAT. Licorice has a detoxifying effect on many drug addictions. In addition, the heart rhythm is not constant because the heart is stuffy and uncomfortable, so that the limbs can not stand still and insomnia and cold, it is effective to treat the symptoms. Therefore, licorice has the effect of suppressing side effects of ephedra as well as detoxification. Licorice contains a large amount (6 to 14%) of triterpene saponins and glycyrrhizin. It also contains glycyrrhizic acid, glycyrrhetinic acid, liqueurin, insoriquiritin, liquiritigenin, insoriquirigeninine and the like.

Wolfberry (Lycii fructus) has an antioxidant action with the other medicine in the composition according to the present invention. Gojija contains a large amount of rutin. As mentioned above, rutin is an antioxidant that promotes the absorption of vitamin C, which is not synthesized in the human body, and has the effect of inhibiting aging. Wolfberry is a mature fruit of Lycium chinense MILL. And Lycium barbatum LINNE. Wolfberry contains polysaccharides such as glycine, betaine, physarin, various amino acids, vitamins B1, B2, and C. On the other hand, goji berries have a cholesterol-lowering action and anti-fatty action. This can also have the effect of weight loss.

Schizandrae fructus (Schizandrae fructus), in the composition according to the present invention, serves to alleviate the bitter taste of herbal medicines, and serves to prevent excessive appetite suppression of ephedra. Schizandra chinensis BAILL. And Schizandra nigra MAXIM. Are the mature fruits of Magnoliaceae. It also uses the fruit of Kadura japonica (THUNB.) DUNAL. Schisandra has a convergent action to shrink the glands of the skin to prevent sweating, and because of lack of bleeding, the heart beats and fails to sleep, which can alleviate many dreamy symptoms. Therefore, Schisandra chinensis has the effect of suppressing the side effects of ephedra. The fruit contains about 3% of essential oils, and the essential oils contain large amounts of sesuccarene, β-2-bisabolene, β-camiglen, and α-ylazine. In addition, it contains 12% citric acid, 10% malic acid, tartaric acid, skidzandrin, deoxysukidrin, γ-skidrindrin, water-γ-skidrindrin, and skidrol.

The composition according to the present invention may be a pharmaceutical composition or may be a food composition. In the case of pharmaceutical compositions, it is administered orally and the dosage is from 0.22 to 0.44 mg per day for adult ephedrine. Formulation may also be in the form of a dry herbal mixture, or may be in the form of a solution composition in which the dry herbal mixture is placed in an extraction solvent and extracted. In addition, when formulated into a pharmaceutical composition, various auxiliaries used in medicine, such as carriers or other additives such as stabilizers, emollients, emulsifiers and the like, may be added as necessary, so long as they do not adversely affect the active ingredient. The formulation may be any formulation suitable for pharmaceutical preparations of herbal ingredients, including tablets, pills, capsules, granules, powders, extracts, premises, acupuncture and the like.

Hereinafter, the present invention will be described in more detail with reference to a preferred embodiment of the present invention, which is for illustrative purposes only and is not intended to limit the scope of the present invention.

Example 1 Preparation of Herbal Dry Mixture

The herbal dry mixture for weight loss according to the present invention was prepared by mixing 12 g of production, 8 g of hawthorn, taxa, 8 g each of Goji, chrysanthemum, upper lobe, C. deciduous, 6 g of Salvia ginseng, 4 g of Ephedra, and 3 g of Schisandra chinensis.

Example 2: Preparation of Liquid Composition

  1400 g of the dry powder mixture of the total amount of 20 tablets (corresponding to the first agent) was added to the volume of the crude drug dry mixture prepared in Example 1, in 5 liters of water for 2 hours at 115 to 120 ° C. 110 ml of the aqueous solution obtained by heating was contained in 48 packs. The medicines thus prepared are taken two packs a day, morning and evening, for 24 minutes at 30 minutes after meals.

Example 3 Preparation of Weight Loss Kit 1

To prepare a weight loss kit comprising a herbal composition for dry weight according to Example 1 in a dose and a weight loss herbal composition consisting of a total of 20 laps together with a pill for preventing the yo-yo phenomenon prepared as follows.

Powder 120g, hawthorn, talcum wolfberry, 80g each, lumps, leaves, gyeoljaja, 60 g each, red ginseng, Schisandra chinensis, 30 g each licorice. 600 g of honey was added to the powder and kneaded to make a ring of mung bean size (0.5 cm in diameter) and dried in the shade. Thus prepared ring was included in the kit in an amount to be taken 40 to 50 tablets 30 minutes after eating three times a day.

The kit is configured to include a guide to first take all of the herbal composition for weight loss and then take the anti-yo-yo pill.

Example 4 Preparation of Weight Loss Kit 2

48 packs of the liquid composition according to Example 2 were composed together with the pill for preventing the yo-yo phenomenon prepared in the same manner as in Example 3 to construct a weight loss kit according to the present invention. The kit is also configured to include a guide for instructing to take the anti-yo-yo pill after first taking all of the weight loss liquid composition.

Experimental Example 1: Clinical Trial of Weight Loss Effect

The weight loss composition according to Example 2 was administered to subjects consisting of three males and nine females having various ages for 24 days to obtain the following results. The following subjects were not different from usual except taking the composition. In other words, they did not reduce their food intake more than usual or did not add exercise that they did not normally do.

No. Age / gender Weight before taking (kg) Weight after taking (kg) Weight loss (kg) One 27 years old / man 72 69.5 2.5 2 41 years old / man 80 74 6 3 51 years old / man 75 74 One 4 53 years old / woman 64 60 4 5 53 years old / woman 60 58 2 6 45 years old / woman 60 59 One 7 27 years old / woman 57 53 4 8 19 years old / woman 58 58 - 9 25 years old / woman 59 59 - 10 26 years old / woman 62 62 - 11 29 years old / woman 69 63 6 12 36 years old / woman 62 58 4

As shown in the table, it was found that the weight loss effect in most subjects.

Experimental Example 2: Yo-Yo Phenomenon Test

After taking the composition according to Example 2 for 24 days according to Experimental Example 1 to the subjects except for the 8 to 10 of the subjects in Experimental Example 1 for 1 month to the yoyo phenomenon prevention pills according to Example 3 As a result of taking 40-50 tablets at 30 minutes after eating 3 times a day, it was confirmed that no yoyo phenomenon occurred in all 9 patients. That is, it was found that the weight lost over the 24 days is maintained for 1 month.

Experimental Example 3: Side Effects Test of Ephedrine

In the composition of Example 2, the daily dose of ephedrine is 0.316 mg. Ephedra used in Example 2 is a total of 4g x 20 = 80g, it is administered for 24 days, so 3.33g of ephedra is administered per day. However, since the content of ephedrine is about 9.49 mg in the extract of the ephedra 100g aqueous solution prepared according to the extraction method of Example 2, the dose of ephedrine consumed per day is 0.316 mg. As mentioned above, the preferred daily dose of ephedrine in the present invention is 0.22 to 0.44 mg / day on an adult basis. Below 0.22 mg / day it is difficult to achieve a sufficient weight loss effect, and above 0.44 mg / day heart attack or seizures and bipolar disorder, delusion, insomnia, palpitations, headaches caused by activation of nerve and heart activity And other side effects may result.

In contrast, the average arterial pressure (MBP) and heart rate (HR) were measured when the daily dose of ephedrine was 0.1 mg, 0.2 mg, 0.22 mg, 0.316 mg, 0.44 mg, 0.5 mg, 1.0 mg, 10 mg. The average arterial pressure (mmHg) and heart rate were measured (78354C Hewlett Packard, USA) at 10 minutes after the dose of ephedrine was administered to 10 healthy adult men and women. Same as

Dose (mg) 0.1 0.2 0.22 0.316 0.4 0.44 0.5 1.0 10 MBP (mmHg) Growth Rate (%) 0 0 0 0 0 0 1.2 1.4 11 HR growth rate (%) 0 0 0 0 0 0 2.5 2.8 25

From the above results, it can be seen that when the daily dose of ephedrine exceeds 0.44 mg, specifically the mean arterial pressure and heart rate start to increase from 0.5 mg or more. Therefore, the daily ephedrine dosages in the range up to 0.44 mg proved safe.

In addition, the composition was prepared in the same manner as in Example 2 for 10 healthy adult men and women, but several compositions were prepared in which the daily dosage of ephedra was varied. The composition was such that the daily doses of ephedra were 1 g, 2 g, 2.33 g (0.22 mg of ephedrine), 3.33 g (0.316 mg of ephedrine, Example 2), 4.67 g (0.44 mg of ephedrine), 4.7 g and 5 g. Each composition prepared as described above was administered to each subject for 24 days per composition for a total of 120 days, and then the change in body weight (reduction rate) was measured. Since then, the weight loss rate of 10 people has averaged. the results are as follow.

Daily dose of ephedra (g) One 2 2.33 3.33 (Example 2 / Experimental Example 1) 4.67 4.7 5 % Weight loss 0.2 1.1 2.98 3.05 3.51 3.78 4.10

As can be seen from the above results, when the daily dose of ephedra is 2g (ephedrine daily dose less than 0.22mg), the weight loss effect is minimal, but from 2.33g (ephedrine daily dose 0.22mg) shows an excellent weight loss effect . Therefore, in order to have a minimal weight loss effect, the daily dose of ephedra must be at least 2.33 g. In other words, the daily dose of ephedrine should be at least 0.22 mg.

Experimental Example 4 Digestive Function Test

Digestive function was measured after taking the composition of Example 2 for 24 days according to Experimental Example 1. Digestive function was measured based on the digestive capacity of the stomach and the state of bowel movements. The digestive ability of the stomach was questioned about subjective symptoms such as heartburn, indigestion, and degree of gas extinguishment when a certain amount of food was ingested. On the other hand, the state of defecation was questioned about subjective symptoms such as the frequency of defecation, the degree of diarrhea, the degree of gas trapping, abdominal pain and the like. The results were as shown in Table 4 below.

No. Age / gender Paperweight for defecation State of digestive function after taking Degree of change One 27 years old / man      +++ +++ Improvement of existing indigestion 2 41 years old / man ++ +++ Heartburn Improvement 3 51 years old / man +++ ++ Gas abatement 4 53 years old / woman ++ ++ Digestion Improvement 5 53 years old / woman ++ +++ Digestion Improvement 6 45 years old / woman +++ ++ Stool thinning 7 27 years old / woman ++ ++ Constipation 8 19 years old / woman + + Little change 9 25 years old / woman + + Little change 10 26 years old / woman + + Digestion seems to be a little 11 29 years old / woman ++ +++ Digestion Improvement 12 36 years old / woman +++ +++ Digestion Improvement

+++: Very effective

++: effective

+: Ineffective or weak

Experimental Example 5 Measurement of Degree of Aging

After taking the composition of Example 2 for 24 days according to Experimental Example 1 was measured for the degree of skin aging of the subjects. The skin elasticity of the subjects was measured by using a cutometer SEM 474: Skin Elasticity Meter, Courage + Khazaka electronic GmbH. The results are shown in Table 5 below.

No. Age / gender Skin elasticity improvement rate (%) One 27 years old / man +1.5 2 41 years old / man +1.2 3 51 years old / man +5.6 4 53 years old / woman +6.2 5 53 years old / woman +7.4 6 45 years old / woman +5.8 7 27 years old / woman +2.3 8 19 years old / woman +5.2 9 25 years old / woman +3.1 10 26 years old / woman +9.4 11 29 years old / woman +1.4 12 36 years old / woman +2.7

As can be seen from the table, it was found that the skin elasticity was rather improved despite weight loss in all the subjects. This proves that the composition according to the invention goes beyond the level of preventing skin elasticity deterioration due to weight loss, but rather to the effect of improving skin elasticity.

Experimental Example 6: Animal Test Data

Sorague-Dawley rats, male strains of 12 weeks old and weighing 380-410 g, were divided into four control groups and eight experimental groups, and the composition of Example 2 was administered orally twice a day for 2 weeks each morning for 4 weeks. Body weight was measured in weeks. The culture conditions of the rats were raised under standard conditions and maintained a normal cycle of 12 hours night / day in a temperature controlled feeding room. First, the results for the control group are shown in the following table. The figures in the table below represent the weight in grams of rats.

1 W 2 W 3 W 4 W 1st control group 417 427 435 446 2nd control group 370 382 393 405 3rd control group 404 415 424 436.5 4th control group 412 425 431 440.5

As shown in the table, in the control group not administered the composition according to the present invention, it was found that the weight naturally increased as the rat grew.

On the other hand, the results for the experimental group is shown in the following table.

1 W 2 W 3 W 4 W Experimental group 1 412 393.5 389 381.5 2nd experimental group 384 380.5 371 368.5 3rd experimental group 383 381 375.5 373 Experimental Group 4 403 403.9 401 396 Experimental Group 5 380 373.5 369 361 Experimental Group 6 408 408 409 409.5 7th experimental group 399 396 388.5 382 Experimental Group 8 411 409.5 401 391

As shown in the table, despite the rat of the growing age, it was found that body weight gradually decreased as a result of administering the composition according to the present invention. Therefore, the herbal composition for weight loss according to the present invention is to demonstrate that there is a weight loss effect. The results of the table are also shown graphically in FIG. 1.

 The herbal composition for weight loss according to the present invention may provide a composition exhibiting sufficient weight loss effect while preventing side effects due to the administration of ephedrine by containing ephedra at a certain concentration. In addition to the weight control effect, considering the peculiar constitution of Asians, it promotes digestion, removes stool, and facilitates bowel movement. In addition, there is an effect of preventing aging due to weight loss to strengthen skin elasticity and reduce wrinkles.

1 is animal test data showing the weight loss effect of the composition according to the present invention.

Claims (13)

delete delete delete delete delete delete delete As a herbal composition for weight loss, Includes ephedra of weight loss function, herbal mixture for enhancing digestion, herbal mixture for antioxidant function, Schisandra chinensis and licorice, The herbal mixture for enhancing digestion is composed of creation, hawthorn, taxa and deficiency, The herbal mixture of the antioxidant function is composed of the upper leaf, lump, Salvia and goji, The ephedra is contained in an amount of 0.22 to 0.44 mg per adult adult daily dose of ephedrine, The creation is 15 to 19% by weight, the hawthorn, tack and the wolfberry are 9 to 13% by weight, respectively, the lumps, the upper leaves, the deficiency and the red ginseng are 7 to 11% by weight, respectively, the amount of Schizandra chinensis and licorice 2 to 6% by weight Herbal composition for weight loss, characterized in that it contains. 9. The herbal composition for weight loss according to claim 8, wherein the ephedra is contained in an amount of 4 to 8% by weight. 10. The herbal composition for weight loss according to claim 9, wherein the composition is a liquid form composition which is an herbal extract mixture or an aqueous solution extract of the herbal mixture mixture. Weight loss kit comprising a herbal composition for weight loss according to claim 9. According to claim 11, The weight loss kit, 15 to 19% by weight based on the active ingredient, 9 to 13% by weight of hawthorn, tack and goji, respectively, 7 to 11% by weight of each, upper leaf, The kit for weight loss, characterized in that it further comprises a yoyo phenomenon prevention pills containing the deficiency and salvia, 2 to 6% by weight of Schisandra chinensis and licorice, respectively. The weight loss kit according to claim 12, wherein the yo-yo phenomenon preventing pill further comprises a guide for instructing to take after taking all of the herbal composition for weight loss according to claim 9.