KR100470348B1 - Rumex crispus linne contained inhibition activity against mycosis - Google Patents

Abstract

The present invention relates to a fungi exhibiting an antifungal effect, and provides an extract of fungi characterized by showing antifungal activity against bacteria causing athlete's foot, eczema, dandruff, white paper or leprosy disease. The extract of the present invention was prepared by pulverizing the pulverized juice or extract extracted after pulverization and to be treated on the lesion site to confirm the therapeutic effect, it is excellent in biocompatibility because there is no toxicity and no toxicity when applying the skin.

Description

RUMEX CRISPUS LINNE CONTAINED INHIBITION ACTIVITY AGAINST MYCOSIS}

The present invention relates to an antifungal extract of the fungi, and more particularly, to an extract of the fungi showing antifungal activity against bacteria causing athlete's foot, eczema, dandruff, white paper or other diseases.

Athlete's foot is a genius ringworm that occurs between the palms, soles of the feet, fingers, and toes. It is a disease caused by a parasitic fungus called ringworm, which is a parasitic and breeding fungus that dissolves the dead skin of the skin and nourish it. It is found in most parts of the body in areas where the dead skin is rich, moist and warm (toes, soles, toenails, nails, flanks, flesh).

The main cause of athlete's foot is Trichophyton mentagro phytes (Trichophyton mentagro phytes), the causative bacteria of the skin fungus including athlete's foot are shown in Table 1 below.

Classification Genus Species Dermatitis Trichophyton rubrun Mentagrophytes Schoenleinii violaceum verrucosun Microsporum canis ferrugineum gypeseum Epidermophyton floccosum yeast fungus Candida albicans parapsilosis tropicalis stellatoidea krusei glabrata Pityrosporum oriculare ovale Malasszia furfur Mold Aspergillus fumigatus Sccopulariopsis bervicaulis

Various fungi shown in Table 1 act on the skin, inducing diseases such as athlete's foot, ringworm, striation, seborrhea, and stubborn.

Various types of drugs have been developed to treat fungal skin diseases including athlete's foot, but it is difficult to cure because it is not easy to safely remove fungi inhabiting the stratum corneum.

Chemosynthetic therapies are currently used as antifungal agents. Among them, ketoconazole and itraconazole, developed by Roxensa, are widely used antifungal agents for athlete's foot, seborrheic dermatitis, completeness and electric wind caused by Candina and dermatophytes. It is known to be effective against cardiac and superficial fungi (US Pat. No. 4,335,125). In addition, pharmaceutical compositions suitable for the treatment of fungal skin diseases by topical administration, in particular, compositions of solutions such as solutions, pastes, ointments, and cosmetics, that is, skin milk croshon, etc. are well known as microscopic application pharmaceutical compositions (Korea Patent Publication No. 90-17590).

In addition, preparations using fungi such as ketoconazole and itraconazole, which are known as chemotherapy agents, have been developed, but may have side effects on the skin when used for a long time.

Accordingly, the present invention aims to provide a safe antifungal plant when applied to the skin.

It is another object of the present invention to provide an antifungal plant which can cure fungal diseases of the skin.

1 is a picture of foot amulet,

2 is a hand athlete's foot photo,

3 is a photograph of the onset of eczema,

Figure 4 is a photograph showing a method of applying the extract of the present invention,

5 is a picture showing a method of applying the extract of the present invention,

Figure 6 is a photograph showing a wound that is recovering after the application of the juice of the extract from the eczema site,

7 is a hand athlete's foot photo,

Figure 8 is a photograph attached to the extract of the extract of the present invention on the hand athlete's foot,

Figure 9 is a photograph showing the site of the groin of the patient before the procedure,

10 is a photograph showing the wound site of the cure the patient,

Figure 11 shows the condition of the athlete's foot athletes before the procedure,

12 is a photograph showing the hand of the patient who was cured one week after the procedure,

Figure 13 shows the state of foot acupuncture before the procedure,

14 is a photograph showing the foot of the patient who was cured one week after the procedure,

Figure 15 is a photograph showing the site of occurrence of the patient

Figure 16 is a photograph showing the area healed three days after the procedure,

17 is a photograph showing the site of the armpits,

18 is a photograph showing the armpit area completely cured,

19 is a photograph showing the occurrence site of the blemish before cure,

20 is a view showing the occurrence of a cured stub,

Figure 21 is a photo of the extract applied to the skin of the rabbit hair removed skin,

Figure 22 is a photograph showing the growth inhibition of dandruff by the ground root powder,

Figure 23 shows athlete's foot fungal antifungal activity by the ground root grinding.

In order to achieve the above object, the present invention provides a chinja exhibiting an antifungal effect. In particular, the antifungal properties provide extracts of the fungus, characterized in that it acts against the bacteria causing the disease selected from the group consisting of athlete's foot, eczema, dandruff, white paper or scrub.

Hereinafter, the present invention will be described in detail.

The present inventors screened plants that are effective against fungal diseases, including athlete's foot, and as a result, it was confirmed that Pleurotus not only has an excellent effect on athlete's foot but also is useful for treating fungal diseases.

The pterosaur of the present invention is a perennial herb, also known as Yangje-geun, Joseon maternal, Sorusuk, Longleaf Sorusung, and Gasoruzin, which grows in the southern, central, and northern regions of Korea. It is used as a medicinal herb in medicinal herbs such as apricot, persimmon, diarrhea, fever, fish blood, dry stomach, jaundice, constipation, pain, postpartum pain and skin pain as a substitute of rhubarb in oriental medicine and private medicine. It is a non-toxic plant.

Raiders can be gathered anywhere in fields, marshes, fields, and outskirts. In addition, the cultivator can grow in large quantities, and can be grown easily without fertilization such as manure.

The nodule has an excellent effect on the treatment of athlete's foot, and is effective in other fungal skin diseases. Fungi are parasitic in the human body and cause about 40 kinds, including Candida, Actinomycetes, Aspergillus, Cryptococcus, Mucor, and Nocardia. The fungal disease is preferably a skin disease caused by the fungus, and more preferably, it is blues, athlete's foot, eczema, dandruff, white paper and ringworm.

The treatment method using a squirrel is preferably prepared by extracting the squirrel in a conventional manner, and more preferably, pulverizes the squirrel and extracts juice to produce a medicament for application. Dryer powder may be dried and covered on the wound, but dryer dryland has the disadvantage of decreasing efficacy. Most preferably, it is washed, then crushed, extracted and then applied to the wound. The amount of coating is appropriate to the skin applied to the skin, the number of times is preferably 1 to 3 times a day, and may be washed after 3 to 6 hours after the application of the dried coating.

In addition, it is preferable to apply the treatment method of the pterosaur differently depending on the site of the disease. For the toenails or nails, apply the extract to the toenail, and the toenails and nails are soaked in the extract, or applied after removing the nail or toenail after soaking in water, or covering the wounded with the crushed powder on the wound It is good to leave it hanging. Dandruff can also be cured by extracting it.

Roots can use both leaves and roots as a medicament, and leaf extracts have a high possibility of deterioration and are less effective than roots, and root extracts are difficult to extract large amounts of extracts while having good shelf life and efficacy. The extract is freeze-stored and can be stored stably without decreasing the long-term efficacy.

In addition, the ridicule of the present invention is an edible plant, which is harmless to animals, and has excellent biocompatibility because it is not warm when applying the skin.

Hereinafter, preferred examples are provided to aid in understanding the present invention. However, the following examples are provided only to more easily understand the present invention, and the present invention is not limited to the following examples.

Example 1

The oleander was collected and washed and the leaves, stems and roots were crushed. The ground product was squeezed into a juice state and then stored frozen.

Example 2

The oleander was collected, washed and then ground. The ground product was stored frozen.

Example 3

The ground roots were collected, washed and crushed to keep the ground frozen.

Example 4

The nymph juice of Example 1 was applied to a patient suffering from foot, foot, or eczema. FIG. 1 is a foot athlete's foot patient, FIG. 2 is a patient's foot athlete's foot patient, and FIG. 3 is an eczema patient.

The foot athlete's foot was washed and then dried, and the wound was applied to the wounded juice of Example 1 once a day and dried. This was carried out three times to confirm the treatment effect. At this time, the coating method was applied using a gauze on the wound in the method of Figure 4 and 5.

The hand athlete's foot was treated in the same way, and after the application, the wound area was discolored, and it was confirmed that it was normal healing when applied for 4 months.

Eczema was performed by attaching the root pulverized product of Example 3 to the lesion site and left for 12 hours. As a result of performing the procedure several times in the same manner, it was confirmed that the lesion area turned red (FIG. 6) and healed within one week.

That is, the foot, foot, ringworm, and eczema shown in the patients of FIGS. 1-3 were cured. The cured lesion photograph could not be obtained by denial of the patients.

Example 5

The finger of the patient suffering from the hand athlete's foot (FIG. 7) was covered with the squid grind of Example 3, and left to rest for 12 hours (FIG. 8).

Experimental Example 1

(1) boats

The patient who developed a clump on the left side of the abdomen was carried out by the method of applying the juice of Example 4. FIG. 9 is a photograph showing a site of a groin in a patient before the procedure, and FIG. 10 is a photograph showing a wound site of a cured patient.

(2) hand athlete's foot

Patients with hand athlete's foot were treated by the root grinding method of Example 4. Figure 11 shows the state of the athlete's foot before the procedure, Figure 12 is a photograph showing the hand of the patient healed one week after the procedure.

(3) foot amulet

Patients with hand and foot were treated by the juice application method of Example 4. FIG. 13 is a view showing the state of a foot muscle of a patient before the procedure, and FIG. 14 is a photograph showing the foot of a patient who is cured one week after the procedure.

(4) buttocks

A patient with a bump on the hip was treated by the method of applying the juice of Example 4. Figure 15 is a photograph showing the site of occurrence of the Chinese character, and Figure 3 shows the area healed after 3 days of the procedure.

(5) armpit

The patient who had an axle in the armpit was treated by the method of application of the juice of Example 4. Three days after the procedure, the rash in the armpit was cured. Figure 17 is a photograph showing the prominent site of the armpit, Figure 18 is a photograph showing the cured armpit site.

(6) neck stump

The method of application of the juice of juice of Example 4 was applied to the neck of a woman who suffered for 40 years due to the neck and back. After the procedure, the site of the clumps turned red and recovered to the skin color after 3-4 days. 19 is a photograph showing the site of the occurrence of the stump before cure, and FIG.

Experimental Example 2

In order to confirm the skin safety of the juice of Example 1, 5 cc of juice was applied to the skin from which the rabbit's hair was removed (FIG. 21), and applied seven times per week to confirm the trauma or behavior of the rabbit. The rabbit did not show any abnormalities.

In addition, the juvenile juice of Example 1 was put into the rabbit's eyes, but the rabbit did not show any abnormality, it was confirmed that the extract of the present invention is not toxic to the living body.

Experimental Example 3

The Biotechnology Research Center asked for the fungus' identification.

Dandruff crushed crushed rootsMalassezia furfurKCTC 7743) and athlete's foot fungus (Trichophyton mentagrophytesKCTC 6077) was placed on the plated plate and cultured by dandruff root grinding Or proliferation inhibition of athlete's foot was confirmed.

22 is a photograph showing the inhibition of the growth of dandruff by the ground roots, it can be seen that the dandruff was not grown around the roots of the ground roots.

Figure 23 shows the athlete's foot fungal antifungal activity by the roots of the ground roots, it can be seen that the athlete's foot fungus near the roots of the ground roots black.

As mentioned above, the extract of the present invention not only has the effect of curing fungal skin diseases, but also has high biocompatibility and can be used without side effects. In addition, the extract is stored frozen and can be stored for a long time, it is very easy to extract the extract and apply the extract.

Claims (5)

A composition for treating a disease of diseases, comprising a juice extract obtained by squeezing after extracting the root of the oleander. delete delete delete delete