KR100210511B1 - 히알루론산나트륨의 정제 방법 및 이에 사용되는 장치 - Google Patents
히알루론산나트륨의 정제 방법 및 이에 사용되는 장치 Download PDFInfo
- Publication number
- KR100210511B1 KR100210511B1 KR1019970007052A KR19970007052A KR100210511B1 KR 100210511 B1 KR100210511 B1 KR 100210511B1 KR 1019970007052 A KR1019970007052 A KR 1019970007052A KR 19970007052 A KR19970007052 A KR 19970007052A KR 100210511 B1 KR100210511 B1 KR 100210511B1
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- KR
- South Korea
- Prior art keywords
- sodium hyaluronate
- recovery
- tank
- precipitate
- recovering
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
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- YWIVKILSMZOHHF-QJZPQSOGSA-N sodium;(2s,3s,4s,5r,6r)-6-[(2s,3r,4r,5s,6r)-3-acetamido-2-[(2s,3s,4r,5r,6r)-6-[(2r,3r,4r,5s,6r)-3-acetamido-2,5-dihydroxy-6-(hydroxymethyl)oxan-4-yl]oxy-2-carboxy-4,5-dihydroxyoxan-3-yl]oxy-5-hydroxy-6-(hydroxymethyl)oxan-4-yl]oxy-3,4,5-trihydroxyoxane-2- Chemical compound [Na+].CC(=O)N[C@H]1[C@H](O)O[C@H](CO)[C@@H](O)[C@@H]1O[C@H]1[C@H](O)[C@@H](O)[C@H](O[C@H]2[C@@H]([C@@H](O[C@H]3[C@@H]([C@@H](O)[C@H](O)[C@H](O3)C(O)=O)O)[C@H](O)[C@@H](CO)O2)NC(C)=O)[C@@H](C(O)=O)O1 YWIVKILSMZOHHF-QJZPQSOGSA-N 0.000 title claims abstract description 94
- 229920002385 Sodium hyaluronate Polymers 0.000 title claims abstract description 93
- 229940010747 sodium hyaluronate Drugs 0.000 title claims abstract description 93
- 238000000034 method Methods 0.000 title claims abstract description 21
- 238000011084 recovery Methods 0.000 claims abstract description 79
- 239000002244 precipitate Substances 0.000 claims abstract description 21
- 238000001556 precipitation Methods 0.000 claims abstract description 20
- 239000003960 organic solvent Substances 0.000 claims abstract description 19
- 239000007788 liquid Substances 0.000 claims abstract description 8
- LFQSCWFLJHTTHZ-UHFFFAOYSA-N Ethanol Chemical group CCO LFQSCWFLJHTTHZ-UHFFFAOYSA-N 0.000 claims description 33
- OKKJLVBELUTLKV-UHFFFAOYSA-N Methanol Chemical compound OC OKKJLVBELUTLKV-UHFFFAOYSA-N 0.000 claims description 21
- 238000004062 sedimentation Methods 0.000 claims description 20
- KFZMGEQAYNKOFK-UHFFFAOYSA-N Isopropanol Chemical compound CC(C)O KFZMGEQAYNKOFK-UHFFFAOYSA-N 0.000 claims description 18
- CSCPPACGZOOCGX-UHFFFAOYSA-N Acetone Chemical compound CC(C)=O CSCPPACGZOOCGX-UHFFFAOYSA-N 0.000 claims description 12
- 239000007864 aqueous solution Substances 0.000 claims description 7
- 239000011148 porous material Substances 0.000 claims description 5
- 238000007599 discharging Methods 0.000 claims description 3
- 238000001914 filtration Methods 0.000 claims description 2
- 239000012046 mixed solvent Substances 0.000 claims description 2
- 239000013049 sediment Substances 0.000 abstract description 23
- 239000002904 solvent Substances 0.000 abstract description 7
- KIUKXJAPPMFGSW-DNGZLQJQSA-N (2S,3S,4S,5R,6R)-6-[(2S,3R,4R,5S,6R)-3-Acetamido-2-[(2S,3S,4R,5R,6R)-6-[(2R,3R,4R,5S,6R)-3-acetamido-2,5-dihydroxy-6-(hydroxymethyl)oxan-4-yl]oxy-2-carboxy-4,5-dihydroxyoxan-3-yl]oxy-5-hydroxy-6-(hydroxymethyl)oxan-4-yl]oxy-3,4,5-trihydroxyoxane-2-carboxylic acid Chemical compound CC(=O)N[C@H]1[C@H](O)O[C@H](CO)[C@@H](O)[C@@H]1O[C@H]1[C@H](O)[C@@H](O)[C@H](O[C@H]2[C@@H]([C@@H](O[C@H]3[C@@H]([C@@H](O)[C@H](O)[C@H](O3)C(O)=O)O)[C@H](O)[C@@H](CO)O2)NC(C)=O)[C@@H](C(O)=O)O1 KIUKXJAPPMFGSW-DNGZLQJQSA-N 0.000 abstract description 2
- 229920002674 hyaluronan Polymers 0.000 abstract description 2
- 229960003160 hyaluronic acid Drugs 0.000 abstract description 2
- 239000000243 solution Substances 0.000 description 12
- 238000003756 stirring Methods 0.000 description 7
- 238000004519 manufacturing process Methods 0.000 description 4
- 238000000746 purification Methods 0.000 description 4
- 238000011109 contamination Methods 0.000 description 3
- 239000011521 glass Substances 0.000 description 3
- 238000013019 agitation Methods 0.000 description 2
- YMKDRGPMQRFJGP-UHFFFAOYSA-M cetylpyridinium chloride Chemical compound [Cl-].CCCCCCCCCCCCCCCC[N+]1=CC=CC=C1 YMKDRGPMQRFJGP-UHFFFAOYSA-M 0.000 description 2
- 229960001927 cetylpyridinium chloride Drugs 0.000 description 2
- 229940079593 drug Drugs 0.000 description 2
- 239000003814 drug Substances 0.000 description 2
- 238000004064 recycling Methods 0.000 description 2
- 229910001220 stainless steel Inorganic materials 0.000 description 2
- 239000010935 stainless steel Substances 0.000 description 2
- 239000002699 waste material Substances 0.000 description 2
- 208000002177 Cataract Diseases 0.000 description 1
- 208000003556 Dry Eye Syndromes Diseases 0.000 description 1
- 206010013774 Dry eye Diseases 0.000 description 1
- 241000287828 Gallus gallus Species 0.000 description 1
- 229920002683 Glycosaminoglycan Polymers 0.000 description 1
- DGAQECJNVWCQMB-PUAWFVPOSA-M Ilexoside XXIX Chemical compound C[C@@H]1CC[C@@]2(CC[C@@]3(C(=CC[C@H]4[C@]3(CC[C@@H]5[C@@]4(CC[C@@H](C5(C)C)OS(=O)(=O)[O-])C)C)[C@@H]2[C@]1(C)O)C)C(=O)O[C@H]6[C@@H]([C@H]([C@@H]([C@H](O6)CO)O)O)O.[Na+] DGAQECJNVWCQMB-PUAWFVPOSA-M 0.000 description 1
- 241000194017 Streptococcus Species 0.000 description 1
- 239000004809 Teflon Substances 0.000 description 1
- 229920006362 Teflon® Polymers 0.000 description 1
- 208000031737 Tissue Adhesions Diseases 0.000 description 1
- 210000005252 bulbus oculi Anatomy 0.000 description 1
- 239000011248 coating agent Substances 0.000 description 1
- 238000000576 coating method Methods 0.000 description 1
- 210000002808 connective tissue Anatomy 0.000 description 1
- 239000002537 cosmetic Substances 0.000 description 1
- 230000000694 effects Effects 0.000 description 1
- 238000012869 ethanol precipitation Methods 0.000 description 1
- 239000003112 inhibitor Substances 0.000 description 1
- 239000002207 metabolite Substances 0.000 description 1
- 244000005700 microbiome Species 0.000 description 1
- 238000002156 mixing Methods 0.000 description 1
- 201000008482 osteoarthritis Diseases 0.000 description 1
- 210000002826 placenta Anatomy 0.000 description 1
- 229920000642 polymer Polymers 0.000 description 1
- 230000001376 precipitating effect Effects 0.000 description 1
- 239000011734 sodium Substances 0.000 description 1
- 229910052708 sodium Inorganic materials 0.000 description 1
- 238000004659 sterilization and disinfection Methods 0.000 description 1
- 238000001356 surgical procedure Methods 0.000 description 1
Images
Classifications
-
- C—CHEMISTRY; METALLURGY
- C08—ORGANIC MACROMOLECULAR COMPOUNDS; THEIR PREPARATION OR CHEMICAL WORKING-UP; COMPOSITIONS BASED THEREON
- C08B—POLYSACCHARIDES; DERIVATIVES THEREOF
- C08B37/00—Preparation of polysaccharides not provided for in groups C08B1/00 - C08B35/00; Derivatives thereof
- C08B37/0003—General processes for their isolation or fractionation, e.g. purification or extraction from biomass
-
- C—CHEMISTRY; METALLURGY
- C08—ORGANIC MACROMOLECULAR COMPOUNDS; THEIR PREPARATION OR CHEMICAL WORKING-UP; COMPOSITIONS BASED THEREON
- C08B—POLYSACCHARIDES; DERIVATIVES THEREOF
- C08B37/00—Preparation of polysaccharides not provided for in groups C08B1/00 - C08B35/00; Derivatives thereof
- C08B37/006—Heteroglycans, i.e. polysaccharides having more than one sugar residue in the main chain in either alternating or less regular sequence; Gellans; Succinoglycans; Arabinogalactans; Tragacanth or gum tragacanth or traganth from Astragalus; Gum Karaya from Sterculia urens; Gum Ghatti from Anogeissus latifolia; Derivatives thereof
- C08B37/0063—Glycosaminoglycans or mucopolysaccharides, e.g. keratan sulfate; Derivatives thereof, e.g. fucoidan
- C08B37/0072—Hyaluronic acid, i.e. HA or hyaluronan; Derivatives thereof, e.g. crosslinked hyaluronic acid (hylan) or hyaluronates
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- Chemical & Material Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Health & Medical Sciences (AREA)
- Biochemistry (AREA)
- Molecular Biology (AREA)
- Engineering & Computer Science (AREA)
- General Health & Medical Sciences (AREA)
- Materials Engineering (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Medicinal Chemistry (AREA)
- Polymers & Plastics (AREA)
- Organic Chemistry (AREA)
- Sustainable Development (AREA)
- Polysaccharides And Polysaccharide Derivatives (AREA)
Abstract
Description
Claims (5)
- 배플이 부착된 침전조에 히알루론산나트륨 수용액과 유기 용매를 유입하여 쉐이커로 회전시키는 단계, 유입액이 일정 높이에 도달하면 침전액은 침전액 배출 밸브를 통해 회수망을 갖춘 회수조로 이송시키고 침전조에 침전되어 있는 히알루론산나트륨을 회수하는 단계, 및 회수조에 이송되어 온 침전액으로부터 히알루론산나트륨을 회수조의 회수망을 통해 회수하고 침전액 만을 회수조의 침전액 배출 밸브를 통해 배출시키는 단계를 포함하는 히알루론산나트륨의 회수 방법.
- 제 1항에 있어서,상기 유기 용매가 에탄올, 메탄올, 이소프로필 알콜, 아세톤 또는 이들의 혼합 용매인 것을 특징으로 하는 방법.
- 제 1 항에 있어서,히알루론산나트륨 수용액과 유기 용매를 1 : 1.5 내지 4의 비율로 유입하는 것을 특징으로 하는 방법.
- 침전조 내벽 및 바닥에 설치된 복수개의 배플, 히알루론산나트륨 유입 밸브, 유기 용매 유입 밸브, 용기 내 압력 조정을 위한 여과 필터가 부착죈 공기 입출 밸브, 침전액 배출 밸브, 침전조 회수캡 및 침전조 저면에 설치된 쉐이커가 구비된 침전조; 및 회수망, 침전액 유입 밸브, 침전액 배출 밸브 및 회수조 회수캡이 구비된 회수조를 포함하는 히알루론산나트륨 회수 장치.
- 제 4 항에 있어서,회수망의 기공 크기가 250 내지 2000㎛ 범위인 것을 특징으로 하는 장치.
Priority Applications (1)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
KR1019970007052A KR100210511B1 (ko) | 1997-03-04 | 1997-03-04 | 히알루론산나트륨의 정제 방법 및 이에 사용되는 장치 |
Applications Claiming Priority (1)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
KR1019970007052A KR100210511B1 (ko) | 1997-03-04 | 1997-03-04 | 히알루론산나트륨의 정제 방법 및 이에 사용되는 장치 |
Publications (2)
Publication Number | Publication Date |
---|---|
KR19980072307A KR19980072307A (ko) | 1998-11-05 |
KR100210511B1 true KR100210511B1 (ko) | 1999-07-15 |
Family
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Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
KR1019970007052A Expired - Fee Related KR100210511B1 (ko) | 1997-03-04 | 1997-03-04 | 히알루론산나트륨의 정제 방법 및 이에 사용되는 장치 |
Country Status (1)
Country | Link |
---|---|
KR (1) | KR100210511B1 (ko) |
Families Citing this family (2)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
KR100836733B1 (ko) * | 2002-11-15 | 2008-06-10 | 코오롱생명과학 주식회사 | 히알우론산 나트륨의 회수방법 및 그를 위한 장치 |
KR101223652B1 (ko) * | 2010-10-07 | 2013-01-17 | 주식회사 한국비엔씨 | 히알루론산 유도체의 입자 제조 장치 및 방법 |
-
1997
- 1997-03-04 KR KR1019970007052A patent/KR100210511B1/ko not_active Expired - Fee Related
Also Published As
Publication number | Publication date |
---|---|
KR19980072307A (ko) | 1998-11-05 |
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Patent event code: PA01091R01D Comment text: Patent Application Patent event date: 19970304 |
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Patent event code: PE07011S01D Comment text: Decision to Grant Registration Patent event date: 19990224 |
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Comment text: Registration of Establishment Patent event date: 19990427 Patent event code: PR07011E01D |
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Payment date: 19990428 End annual number: 3 Start annual number: 1 |
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Termination category: Default of registration fee Termination date: 20060410 |