KR0134377B1 - 에글린 b 및 에글린 c의 돌연변이체, 이를 암호화하는 dna 서열, 이러한 dna를 포함하는 재조합 벡터, 이러한 벡터로 형질전환된 숙주, 돌연변이체를 제조하는 방법 및 돌연변이체를 함유하는 약제학적 조성물 - Google Patents

에글린 b 및 에글린 c의 돌연변이체, 이를 암호화하는 dna 서열, 이러한 dna를 포함하는 재조합 벡터, 이러한 벡터로 형질전환된 숙주, 돌연변이체를 제조하는 방법 및 돌연변이체를 함유하는 약제학적 조성물

Info

Publication number: KR0134377B1
Authority: KR; South Korea
Prior art keywords: eglin; mutants; dna; formula; compound
Prior art date: 1988-03-07
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.): Expired - Fee Related

Application number

KR1019890002759A

Other languages

English (en)

Korean (ko)

Other versions

KR890014735A (ko

Inventor

게르아트트 그뤼터 마르쿠스

하인츠 디르크

리르슈 만프레드

Original Assignee

로트베른하르트 엠., 발덱 베르너

노바르티스 아게

베르너 에이. 레슈타이너

유씨피 겐-파르마 에이지

Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)

1988-03-07

Filing date

1989-03-07

Publication date

1998-04-20

1989-03-07 Application filed by 로트베른하르트 엠., 발덱 베르너, 노바르티스 아게, 베르너 에이. 레슈타이너, 유씨피 겐-파르마 에이지 filed Critical 로트베른하르트 엠., 발덱 베르너

1989-10-25 Publication of KR890014735A publication Critical patent/KR890014735A/ko

1998-04-20 Application granted granted Critical

1998-04-20 Publication of KR0134377B1 publication Critical patent/KR0134377B1/ko

2009-03-07 Anticipated expiration legal-status Critical

Status Expired - Fee Related legal-status Critical Current

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Classifications

- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
- C12N15/09—Recombinant DNA-technology
- C12N15/63—Introduction of foreign genetic material using vectors; Vectors; Use of hosts therefor; Regulation of expression
- C12N15/79—Vectors or expression systems specially adapted for eukaryotic hosts
- C12N15/80—Vectors or expression systems specially adapted for eukaryotic hosts for fungi
- C12N15/81—Vectors or expression systems specially adapted for eukaryotic hosts for fungi for yeasts
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K38/00—Medicinal preparations containing peptides
- A61K38/16—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- A61K38/55—Protease inhibitors
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P11/00—Drugs for disorders of the respiratory system
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- C07K14/81—Protease inhibitors
- C07K14/815—Protease inhibitors from leeches, e.g. hirudin, eglin
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K7/00—Peptides having 5 to 20 amino acids in a fully defined sequence; Derivatives thereof
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
- C12N15/09—Recombinant DNA-technology
- C12N15/63—Introduction of foreign genetic material using vectors; Vectors; Use of hosts therefor; Regulation of expression
- C12N15/79—Vectors or expression systems specially adapted for eukaryotic hosts
- C12N15/82—Vectors or expression systems specially adapted for eukaryotic hosts for plant cells, e.g. plant artificial chromosomes (PACs)
- C12N15/8241—Phenotypically and genetically modified plants via recombinant DNA technology
- C12N15/8261—Phenotypically and genetically modified plants via recombinant DNA technology with agronomic (input) traits, e.g. crop yield
- C12N15/8271—Phenotypically and genetically modified plants via recombinant DNA technology with agronomic (input) traits, e.g. crop yield for stress resistance, e.g. heavy metal resistance
- C12N15/8279—Phenotypically and genetically modified plants via recombinant DNA technology with agronomic (input) traits, e.g. crop yield for stress resistance, e.g. heavy metal resistance for biotic stress resistance, pathogen resistance, disease resistance
- C12N15/8286—Phenotypically and genetically modified plants via recombinant DNA technology with agronomic (input) traits, e.g. crop yield for stress resistance, e.g. heavy metal resistance for biotic stress resistance, pathogen resistance, disease resistance for insect resistance
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K38/00—Medicinal preparations containing peptides
- Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
- Y02—TECHNOLOGIES OR APPLICATIONS FOR MITIGATION OR ADAPTATION AGAINST CLIMATE CHANGE
- Y02A—TECHNOLOGIES FOR ADAPTATION TO CLIMATE CHANGE
- Y02A40/00—Adaptation technologies in agriculture, forestry, livestock or agroalimentary production
- Y02A40/10—Adaptation technologies in agriculture, forestry, livestock or agroalimentary production in agriculture
- Y02A40/146—Genetically Modified [GMO] plants, e.g. transgenic plants
- Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
- Y10—TECHNICAL SUBJECTS COVERED BY FORMER USPC
- Y10S—TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
- Y10S530/00—Chemistry: natural resins or derivatives; peptides or proteins; lignins or reaction products thereof
- Y10S530/855—Proteins from animals other than mammals or birds

Landscapes

Health & Medical Sciences (AREA)
Life Sciences & Earth Sciences (AREA)
Genetics & Genomics (AREA)
Chemical & Material Sciences (AREA)
Organic Chemistry (AREA)
Engineering & Computer Science (AREA)
Bioinformatics & Cheminformatics (AREA)
General Health & Medical Sciences (AREA)
Wood Science & Technology (AREA)
Molecular Biology (AREA)
Biomedical Technology (AREA)
Biotechnology (AREA)
Zoology (AREA)
General Engineering & Computer Science (AREA)
Medicinal Chemistry (AREA)
Biophysics (AREA)
Biochemistry (AREA)
Public Health (AREA)
Microbiology (AREA)
Physics & Mathematics (AREA)
Veterinary Medicine (AREA)
Plant Pathology (AREA)
Animal Behavior & Ethology (AREA)
Pharmacology & Pharmacy (AREA)
Proteomics, Peptides & Aminoacids (AREA)
Mycology (AREA)
Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
Chemical Kinetics & Catalysis (AREA)
General Chemical & Material Sciences (AREA)
Gastroenterology & Hepatology (AREA)
Cell Biology (AREA)
Pest Control & Pesticides (AREA)
Insects & Arthropods (AREA)
Tropical Medicine & Parasitology (AREA)
Rheumatology (AREA)
Epidemiology (AREA)
Heart & Thoracic Surgery (AREA)
Pain & Pain Management (AREA)
Cardiology (AREA)
Immunology (AREA)

KR1019890002759A 1988-03-07 1989-03-07 에글린 b 및 에글린 c의 돌연변이체, 이를 암호화하는 dna 서열, 이러한 dna를 포함하는 재조합 벡터, 이러한 벡터로 형질전환된 숙주, 돌연변이체를 제조하는 방법 및 돌연변이체를 함유하는 약제학적 조성물 Expired - Fee Related KR0134377B1 (ko)

Applications Claiming Priority (2)

Application Number	Priority Date	Filing Date	Title
CH84088		1988-03-07
CH840/88-6		1988-03-07

Publications (2)

Publication Number	Publication Date
KR890014735A KR890014735A (ko)	1989-10-25
KR0134377B1 true KR0134377B1 (ko)	1998-04-20

Family

ID=4196431

Family Applications (1)

Application Number	Title	Priority Date	Filing Date
KR1019890002759A Expired - Fee Related KR0134377B1 (ko)	1988-03-07	1989-03-07	에글린 b 및 에글린 c의 돌연변이체, 이를 암호화하는 dna 서열, 이러한 dna를 포함하는 재조합 벡터, 이러한 벡터로 형질전환된 숙주, 돌연변이체를 제조하는 방법 및 돌연변이체를 함유하는 약제학적 조성물

Country Status (20)

Country	Link
US (1)	US5079229A (no)
EP (1)	EP0332576B1 (no)
JP (1)	JP2716191B2 (no)
KR (1)	KR0134377B1 (no)
AT (1)	ATE103930T1 (no)
AU (1)	AU623881B2 (no)
CA (1)	CA1339105C (no)
DD (1)	DD283645A5 (no)
DE (1)	DE58907373D1 (no)
DK (1)	DK107389A (no)
ES (1)	ES2063161T3 (no)
FI (1)	FI96116C (no)
HU (1)	HU209401B (no)
IE (1)	IE62993B1 (no)
IL (1)	IL89496A0 (no)
NO (1)	NO178870C (no)
NZ (1)	NZ228208A (no)
PT (1)	PT89916B (no)
TW (1)	TW211522B (no)
ZA (1)	ZA891679B (no)

Families Citing this family (6)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
US6342373B1 (en) *	1983-11-21	2002-01-29	Ucp Gen-Pharma Ag	Process for preparing recombinant eglin, protease inhibitor
US5674833A (en) *	1990-09-18	1997-10-07	Novo Nordisk A/S	Detergent compositions containing protease and novel inhibitors for use therein
US5604201A (en) *	1993-01-08	1997-02-18	State Of Oregon, Acting By And Through The Oregon State Board Of Higher Education On Behalf Of The Oregon Health Sciences University, A Non-Profit Organization	Methods and reagents for inhibiting furin endoprotease
TW492975B (en) *	1993-07-26	2002-07-01	Novartis Ag	Tryptase inhibitor
US6579698B1 (en)	1996-09-24	2003-06-17	The Procter & Gamble Company	Stabilized proteinaceous protease inhibitors and variants thereof
US7001884B2 (en) *	2001-06-18	2006-02-21	Regents Of The University Of Michigan	Eglin c based drugs for treatment of disease

Family Cites Families (8)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
GB2125047B (en) *	1982-08-09	1986-02-19	Ciba Geigy Ag	Yeast hybrid vectors and their use for the production of polypeptides
DE3324534A1 (de) *	1983-07-07	1985-01-17	Ciba-Geigy Ag, Basel	Modifizierte protease-inhibitoren, verfahren zu ihrer herstellung und daraus bereitete pharmazeutische mittel
GR80965B (en) *	1983-11-21	1985-03-20	Ciba Geigy Ag	Method for the preparation of protease inhibitors
US4711848A (en) *	1984-03-14	1987-12-08	Zymogenetics, Inc.	Site specific mutagenesis in alpha-1-antitrypsin
DE3585969D1 (de) *	1984-06-14	1992-06-11	Chiron Corp	Protease-inhibitoren des alpha-1-antitrypsin typs mit modifizierter aktiever stelle und deren herstellung.
HU204563B (en) *	1984-12-06	1992-01-28	Synergen Biolog Inc	Process for producing recombinant serine-protease inhibitors and dns sequencyes for them
GB2188322A (en) *	1986-03-26	1987-09-30	Bayer Ag	Aprotinin and analogues thereof produced by a recombinant host
GB2199582A (en) *	1987-01-07	1988-07-13	Bayer Ag	Analogues of pancreatic secretory trypsin inhibitor

1989
- 1989-02-28 ES ES89810152T patent/ES2063161T3/es not_active Expired - Lifetime
- 1989-02-28 DE DE89810152T patent/DE58907373D1/de not_active Expired - Fee Related
- 1989-02-28 AT AT89810152T patent/ATE103930T1/de not_active IP Right Cessation
- 1989-02-28 EP EP89810152A patent/EP0332576B1/de not_active Expired - Lifetime
- 1989-03-03 AU AU30959/89A patent/AU623881B2/en not_active Ceased
- 1989-03-03 FI FI891020A patent/FI96116C/fi not_active IP Right Cessation
- 1989-03-03 CA CA000592686A patent/CA1339105C/en not_active Expired - Fee Related
- 1989-03-03 NZ NZ228208A patent/NZ228208A/xx unknown
- 1989-03-06 IE IE71989A patent/IE62993B1/en not_active IP Right Cessation
- 1989-03-06 ZA ZA891679A patent/ZA891679B/xx unknown
- 1989-03-06 HU HU891101A patent/HU209401B/hu not_active IP Right Cessation
- 1989-03-06 PT PT89916A patent/PT89916B/pt not_active IP Right Cessation
- 1989-03-06 DD DD89326310A patent/DD283645A5/de not_active IP Right Cessation
- 1989-03-06 DK DK107389A patent/DK107389A/da not_active Application Discontinuation
- 1989-03-06 IL IL89496A patent/IL89496A0/xx not_active IP Right Cessation
- 1989-03-06 NO NO890932A patent/NO178870C/no not_active IP Right Cessation
- 1989-03-07 US US07/320,139 patent/US5079229A/en not_active Expired - Fee Related
- 1989-03-07 TW TW078101663A patent/TW211522B/zh active
- 1989-03-07 KR KR1019890002759A patent/KR0134377B1/ko not_active Expired - Fee Related
- 1989-03-07 JP JP1053065A patent/JP2716191B2/ja not_active Expired - Lifetime

Also Published As

Publication number	Publication date
EP0332576A3 (en)	1990-09-12
JP2716191B2 (ja)	1998-02-18
US5079229A (en)	1992-01-07
DD283645A5 (de)	1990-10-17
FI891020L (fi)	1989-09-08
IE62993B1 (en)	1995-03-08
HU209401B (en)	1994-05-30
EP0332576B1 (de)	1994-04-06
FI96116B (fi)	1996-01-31
KR890014735A (ko)	1989-10-25
CA1339105C (en)	1997-07-29
DK107389D0 (da)	1989-03-06
AU623881B2 (en)	1992-05-28
NO178870C (no)	1996-06-19
PT89916A (pt)	1989-11-10
DE58907373D1 (de)	1994-05-11
ES2063161T3 (es)	1995-01-01
ATE103930T1 (de)	1994-04-15
EP0332576A2 (de)	1989-09-13
FI891020A0 (fi)	1989-03-03
DK107389A (da)	1989-09-08
AU3095989A (en)	1989-09-07
NO890932D0 (no)	1989-03-06
IL89496A0 (en)	1989-09-10
NO890932L (no)	1989-09-08
NO178870B (no)	1996-03-11
FI96116C (fi)	1996-05-10
JPH029392A (ja)	1990-01-12
TW211522B (no)	1993-08-21
IE890719L (en)	1989-09-07
HUT50503A (en)	1990-02-28
PT89916B (pt)	1994-05-31
ZA891679B (en)	1989-10-25
NZ228208A (en)	1990-08-28

Publication	Publication Date	Title
AU604953B2 (en)	1991-01-03	Variants of bovine pancreatic trypsin inhibitor produced by recombinant dna technology, process, expression vector and recombinant host therefor and pharmaceutical use thereof
CA1339106C (en)	1997-07-29	Hirullin polypeptides having anticoagulant activity
JPH08504568A (ja)	1996-05-21	ウシ膵トリプシン阻害因子から誘導される因子ＶＩＩａ−組織因子複合体の阻害因子
CA1326216C (en)	1994-01-18	Dna sequences coding for proteins having the biological activity of husi-type i inhibitors, biotechnological methods for the preparation of said proteins and pharmaceutical compositions containing said proteins
FI104724B (fi)	2000-03-31	Menetelmä aprotiniinivarianttien valmistamiseksi
US5079336A (en)	1992-01-07	α-1-antichymotrypsin, analogues and methods of production
KR0134377B1 (ko)	1998-04-20	에글린 b 및 에글린 c의 돌연변이체, 이를 암호화하는 dna 서열, 이러한 dna를 포함하는 재조합 벡터, 이러한 벡터로 형질전환된 숙주, 돌연변이체를 제조하는 방법 및 돌연변이체를 함유하는 약제학적 조성물
WO1988003171A1 (en)	1988-05-05	Human pancreatic secretory trypsin inhibitors produced by recombinant dna methods and processes for the production of same
US5180667A (en)	1993-01-19	Genes encoding eglin C mutants
US5268296A (en)	1993-12-07	DNA vector and recombinant host cell for production of hirullin P6 and P18
US5552299A (en)	1996-09-03	Plasmids and process for producing recombinant desulphatohirudin HV-1 peptides
EP0352227A2 (en)	1990-01-24	Modified proteins
DE69432975T2 (de)	2004-05-06	Tryptase hemmer
US5231010A (en)	1993-07-27	Recombinant aprotinin variants genetically engineered process for the microbial preparation of homogeneously processed aprotinin variants and the therapeutic use thereof
US6077827A (en)	2000-06-20	Family of peptides known as xenoxins
US5739283A (en)	1998-04-14	Prevention of invasive pulmonary aspergillosis with serine proteinase inhibitors
CA2124330A1 (en)	1994-04-14	Novel hirudine variant, process for producing the same, and anticoagulant containing the same as active ingredient
JPH0746995A (ja)	1995-02-21	プラスミド及び組替え体デスルファトヒルヂンｈｖ−１ペプチドの製法

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