JPWO2021038291A5 - - Google Patents
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- JPWO2021038291A5 JPWO2021038291A5 JP2022513602A JP2022513602A JPWO2021038291A5 JP WO2021038291 A5 JPWO2021038291 A5 JP WO2021038291A5 JP 2022513602 A JP2022513602 A JP 2022513602A JP 2022513602 A JP2022513602 A JP 2022513602A JP WO2021038291 A5 JPWO2021038291 A5 JP WO2021038291A5
- Authority
- JP
- Japan
- Prior art keywords
- catheter
- locoregional
- heart
- perfusion system
- collection
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
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- 230000010412 perfusion Effects 0.000 claims 32
- 238000012377 drug delivery Methods 0.000 claims 16
- 210000004351 coronary vessel Anatomy 0.000 claims 14
- 239000003814 drug Substances 0.000 claims 10
- 229940079593 drug Drugs 0.000 claims 10
- 239000012528 membrane Substances 0.000 claims 10
- 238000000034 method Methods 0.000 claims 8
- 210000003748 coronary sinus Anatomy 0.000 claims 7
- 239000008280 blood Substances 0.000 claims 5
- 210000004369 blood Anatomy 0.000 claims 5
- 230000001839 systemic circulation Effects 0.000 claims 4
- 210000000709 aorta Anatomy 0.000 claims 3
- 238000003780 insertion Methods 0.000 claims 3
- 230000037431 insertion Effects 0.000 claims 3
- QVGXLLKOCUKJST-UHFFFAOYSA-N atomic oxygen Chemical compound [O] QVGXLLKOCUKJST-UHFFFAOYSA-N 0.000 claims 2
- 238000010009 beating Methods 0.000 claims 2
- 230000004087 circulation Effects 0.000 claims 2
- 239000012530 fluid Substances 0.000 claims 2
- 229910052760 oxygen Inorganic materials 0.000 claims 2
- 239000001301 oxygen Substances 0.000 claims 2
- 238000002627 tracheal intubation Methods 0.000 claims 2
- 210000003191 femoral vein Anatomy 0.000 claims 1
- 210000004731 jugular vein Anatomy 0.000 claims 1
- 230000000284 resting effect Effects 0.000 claims 1
Claims (24)
前記心臓の右冠動脈に第１の薬物送達カテーテルを配置すること、
前記心臓の左冠動脈主幹部に第２の薬物送達カテーテルを配置すること、
前記心臓の冠静脈洞に薬物収集カテーテルを配置することであって、前記第１の薬物送達カテーテル、前記第２の薬物送達カテーテル、および前記薬物収集カテーテルが、前記心臓の冠動脈、前記心臓の冠静脈系、および膜型人工肺デバイスと共に、閉じた回路を形成する、前記配置すること、ならびに
前記閉じた回路を通じて前記薬物を灌流させることであって、前記閉じた回路が、前記患者の全身循環から前記患者の冠動脈循環を分離する、前記灌流させること
を含む、前記局所領域灌流システム。 A locoregional perfusion system for use in performing a method of perfusing a drug in a non-paused beating heart of a patient, said method comprising:
placing a first drug delivery catheter in the right coronary artery of the heart;
placing a second drug delivery catheter in the left main coronary artery of the heart;
placing a drug collection catheter in the coronary sinus of the heart, wherein the first drug delivery catheter, the second drug delivery catheter, and the drug collection catheter are connected to the coronary artery of the heart, the coronary artery of the heart; forming a closed circuit with a venous system and a membrane oxygenator; said perfusing, separating said patient's coronary circulation from said locoregional perfusion system .
前記心臓の右冠動脈に第１のカテーテルを配置すること、
前記心臓の左冠動脈主幹部に第２のカテーテルを配置すること、
前記心臓の冠静脈洞に収集カテーテルを配置することであって、前記第１のカテーテル、前記第２のカテーテル、および前記収集カテーテルが、冠動脈、冠静脈系、および膜型人工肺デバイスと共に、前記心臓を通じた前記閉じた回路を形成する、前記配置すること、ならびに
前記第１のカテーテルおよび前記第２のカテーテルを介して前記心臓に前記灌流液を導入することにより前記閉じた回路を通じて前記灌流液を流すことおよび前記収集カテーテルを介して前記灌流液を収集することであって、前記閉じた回路が、前記患者の全身循環から前記患者の冠動脈循環を分離する、前記流すことおよび前記収集すること
を含む、前記局所領域灌流システム。 A locoregional perfusion system used to perform a method of maintaining perfusion of perfusate through a closed circuit in a patient's heart, wherein the heart is not resting and beating during said perfusion. and the method comprises:
placing a first catheter in the right coronary artery of the heart;
placing a second catheter in the left main coronary artery of the heart;
placing a collection catheter in the coronary sinus of the heart, wherein the first catheter, the second catheter, and the collection catheter, along with the coronary arteries, the coronary venous system, and the membrane oxygenator device, the forming the closed circuit through the heart, placing the perfusate through the closed circuit by introducing the perfusate into the heart through the first catheter and the second catheter; and collecting the perfusate via the collection catheter, wherein the closed circuit separates the patient's coronary circulation from the patient's systemic circulation; the locoregional perfusion system comprising:
前記心臓の右冠動脈への挿入のために適合された第１のカテーテル、
前記心臓の左冠動脈主幹部への挿入のために適合された第２のカテーテル、
前記心臓の冠静脈洞への挿入のために適合された収集カテーテル、
前記第１のカテーテル、前記第２のカテーテル、前記収集カテーテル、および酸素供給源に流体連結される膜型人工肺デバイスであって、前記第１のカテーテル、前記第２のカテーテル、前記収集カテーテル、および前記膜型人工肺デバイスが一緒になって、前記第１のカテーテルが前記右冠動脈に挿入され、前記第２のカテーテルが前記左冠動脈主幹部に挿入され、かつ前記収集カテーテルが前記冠静脈洞に挿入された場合に、前記患者の全身循環から分離された、前記心臓を通じた閉じた回路を形成する、前記膜型人工肺デバイス、ならびに
前記第１のカテーテルおよび前記第２のカテーテルを通じた流体流れを駆動するように構成されたポンプ
を含む、システム。 A system for performing locoregional perfusion within a patient's heart when fluidly coupled to the heart, comprising:
a first catheter adapted for insertion into the right coronary artery of said heart;
a second catheter adapted for insertion into the left main coronary artery of said heart;
a collection catheter adapted for insertion into the coronary sinus of said heart;
A membrane oxygenator device fluidly connected to the first catheter, the second catheter, the collection catheter, and an oxygen source, wherein the first catheter, the second catheter, the collection catheter, and the membrane oxygenator device together, the first catheter is inserted into the right coronary artery, the second catheter is inserted into the left main coronary artery, and the collection catheter is inserted into the coronary sinus. said membrane oxygenator forming a closed circuit through said heart isolated from said patient's systemic circulation when inserted into said patient's systemic circulation, and fluid through said first and said second catheters A system including a pump configured to drive a flow.
患者の心臓の右冠動脈に挿入される第１のカテーテル、
前記心臓の左冠動脈主幹部に挿入される第２のカテーテル、
前記心臓の冠静脈洞に挿入される収集カテーテル、ならびに
前記第１のカテーテル、前記第２のカテーテル、前記収集カテーテル、および酸素供給源に流体連結される膜型人工肺デバイスであって、前記第１のカテーテル、前記第２のカテーテル、前記収集カテーテル、および前記膜型人工肺デバイスが、前記心臓の冠動脈および冠静脈系と共に、前記患者の全身循環から分離された、前記心臓を通じた閉じた回路を形成する、前記膜型人工肺デバイス、ならびに
前記第１のカテーテルおよび前記第２のカテーテルを介する前記心臓へのおよび前記収集カテーテルを介する前記心臓の外への流体流れを駆動するように構成されたポンプ
を含む、局所領域灌流システム。 A locoregional perfusion system comprising:
a first catheter inserted into the right coronary artery of the patient's heart;
a second catheter inserted into the left main coronary artery of the heart;
a collection catheter inserted into the coronary sinus of the heart; and a membrane oxygenator fluidly connected to the first catheter, the second catheter, the collection catheter, and an oxygen source, wherein the second A closed circuit through the heart in which one catheter, the second catheter, the collection catheter, and the membrane oxygenator device, along with the heart's coronary arteries and coronary venous system, are isolated from the patient's systemic circulation. and configured to drive fluid flow into the heart via the first and second catheters and out of the heart via the collection catheter, forming a A locoregional perfusion system comprising a pump.
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US201962892164P | 2019-08-27 | 2019-08-27 | |
| US62/892,164 | 2019-08-27 | ||
| PCT/IB2020/000692 WO2021038291A1 (en) | 2019-08-27 | 2020-08-26 | Drug perfusion into an unarrested beating heart |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| JP2022545955A JP2022545955A (en) | 2022-11-01 |
| JPWO2021038291A5 true JPWO2021038291A5 (en) | 2023-08-31 |
Family
ID=72561828
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2022513602A Pending JP2022545955A (en) | 2019-08-27 | 2020-08-26 | Drug perfusion into a nonstop beating heart |
Country Status (10)
| Country | Link |
|---|---|
| US (1) | US20220273854A1 (en) |
| EP (2) | EP4021527B1 (en) |
| JP (1) | JP2022545955A (en) |
| KR (1) | KR20220119595A (en) |
| AU (1) | AU2020338946B2 (en) |
| CA (1) | CA3149444A1 (en) |
| ES (1) | ES2980074T3 (en) |
| IL (1) | IL290907A (en) |
| TW (1) | TWI873173B (en) |
| WO (1) | WO2021038291A1 (en) |
Families Citing this family (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CA3171166A1 (en) | 2020-02-13 | 2021-08-19 | Tenaya Therapeutics, Inc. | Gene therapy vectors for treating heart disease |
| AU2022223654A1 (en) * | 2021-02-22 | 2023-09-14 | Dinaqor Ag | Loco-regional perfusion of an unarrested beating heart |
Family Cites Families (7)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US6673039B1 (en) * | 1997-12-19 | 2004-01-06 | Trustees Of The University Of Pennsylvania | Compositions, kits, methods, and apparatus for transvascular delivery of a composition to an extravascular tissue of a mammal |
| US20040102732A1 (en) * | 2002-06-19 | 2004-05-27 | Morteza Naghavi | Dialysis system for treatment of vulnerable patients and methods of use |
| US20070203445A1 (en) * | 2004-02-26 | 2007-08-30 | V-Kardia Pty Ltd | Isolating cardiac circulation |
| EP2313126A4 (en) * | 2008-07-17 | 2018-03-28 | Rheoxtech, LLC | Method and apparatus for mitigating acute reoxygenation injury during percutaneous coronary intervention |
| WO2013012776A1 (en) * | 2011-07-15 | 2013-01-24 | Cardiac Assist, Inc. | Apparatus and method for rapidly cooling or heating the body temperature of a patient |
| CN204684306U (en) * | 2015-06-02 | 2015-10-07 | 刘燕 | Operation on heart Wicresoft joint blood group extracorporeal circulation apparatus |
| WO2018013644A1 (en) * | 2016-07-12 | 2018-01-18 | 3R International Co., Ltd. | Extracorporeal life support system |
-
2020
- 2020-08-26 CA CA3149444A patent/CA3149444A1/en active Pending
- 2020-08-26 JP JP2022513602A patent/JP2022545955A/en active Pending
- 2020-08-26 AU AU2020338946A patent/AU2020338946B2/en active Active
- 2020-08-26 EP EP20775396.3A patent/EP4021527B1/en active Active
- 2020-08-26 US US17/638,081 patent/US20220273854A1/en active Pending
- 2020-08-26 KR KR1020227009667A patent/KR20220119595A/en active Pending
- 2020-08-26 ES ES20775396T patent/ES2980074T3/en active Active
- 2020-08-26 EP EP24155532.5A patent/EP4371591A3/en active Pending
- 2020-08-26 WO PCT/IB2020/000692 patent/WO2021038291A1/en active Application Filing
- 2020-08-27 TW TW109129333A patent/TWI873173B/en active
-
2022
- 2022-02-24 IL IL290907A patent/IL290907A/en unknown
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