JPWO2020159783A5 - - Google Patents

Claims (25)

an annular frame having an inflow end and an outflow end;
at least one actuator mounted to the frame, the actuator configured to radially expand or compress the frame between a radially compressed configuration and a radially expanded configuration;
an annular skirt having a fold extending around the inflow end of the frame to cover at least a portion of the outer surface of the frame and at least a portion of the inner surface of the frame;
When the frame is in the radially expanded configuration, the outer portion of the skirt fits tightly against the outer surface of the frame, and the inflow end of the frame defines an axially extending gap between the frame and the fold. axially spaced from the fold, and the inflow end of the frame is axially spaced so as to at least partially fill the axially extending gap when the frame is in the radially compressed configuration. A prosthetic valve extending in a direction. 2. The prosthetic valve of claim 1 , wherein the at least one actuator is one of a plurality of actuators mounted on the inner surface of the frame and equally spaced around the inner surface of the frame. The at least one actuator includes a first tether attached to the frame at a first location, a second tether secured to the frame at a second location, the first tether and the and a bar extending through a second anchorage, the second location being closer to the inflow end of the frame than the first location, the bar radially compressing the frame. 3. The prosthetic valve of claim 1 or 2 , configured to increase or decrease the distance between the first location and the second location, respectively, to expand or expand. 4. The prosthetic valve of claim 3 , wherein the bar comprises external threads configured to matingly engage internal threads of the second anchor. 5. The claim 3 or 4 , wherein the first location is a joint between two overlapping struts of the frame, and the first anchoring portion is hinged to the joint by a fastener. prosthetic valve. 10. The at least one actuator comprises a bar at least partially received within a sleeve, wherein axial movement of the bar relative to the sleeve causes radial expansion or compression of the frame or 2. The prosthetic valve according to 2. 7. The prosthetic valve of Claim 6 , wherein the at least one actuator comprises a locking mechanism configured to lock the frame in the radially expanded configuration. The at least one actuator is aligned with the corresponding actuating member of the delivery device such that the actuating member of the delivery device can exert a force on the at least one actuator to radially compress or expand the frame. 8. The prosthetic valve of any one of claims 1-7 , comprising an attachment member configured to form a releasable connection. 9. Any of claims 1-8 , further comprising a valve structure positioned within the frame and configured to allow blood flow through the prosthetic valve in one direction and block blood flow in an opposite direction. or the prosthetic valve according to item 1. The valve structure comprises a plurality of leaflets each having an inflow edge portion, the inflow edge portions of the leaflets extending circumferentially relative to each other of the frame when the frame is in the radially expanded configuration. 10. The prosthetic valve of claim 9 , defining an undulating curved corrugation that follows a plurality of connected strut segments. 11. The prosthetic valve of any one of claims 1-10 , wherein the outer portion of the skirt is axially longer than the inner portion of the skirt. 11. The prosthetic valve of any one of claims 1-10 , wherein the outer portion of the skirt has approximately the same axial length as the inner portion of the skirt. 11. The prosthetic valve of any one of claims 1-10 , wherein the outer portion of the skirt is axially shorter than the inner portion of the skirt. 14. The prosthetic valve of any one of claims 1-13 , wherein the outer portion of the skirt is circumferentially stretched when the frame is in the expanded configuration. 15. The prosthetic valve of claim 14 , wherein the upper edge of the outer portion of the skirt is generally straight prior to attachment to the frame. 16. The prosthetic valve of claim 15 , wherein the upper edge of the outer portion of the skirt is attached to the frame at a plurality of pivot joints formed by overlapping struts of the frame. 15. The prosthetic valve of claim 14 , wherein the upper edge of the outer portion of the skirt has an undulating shape and is stitched along rows of strut sections of the frame. A tether coupled to the skirt such that the tether prevents the fold from moving inwardly of the frame when the frame is radially expanded from the compressed configuration to the expanded configuration. 18. The prosthetic valve of any one of claims 1-17 , further comprising a tether extending at an oblique angle to the fold to apply tension to the skirt. 19. The prosthetic valve of claim 18 , wherein the oblique angle ranges from about 10[deg.] to about 80[deg.]. 20. The prosthetic valve of claim 19 , wherein the oblique angle ranges from about 30[deg.] to about 60[deg.]. 21. The prosthetic valve of claim 20 , wherein said oblique angle is about 45[deg.]. 22. Any one of claims 18-21 , wherein a first end of the tether is positioned at an outflow edge portion of the outer portion of the skirt and a second end of the tether is positioned adjacent the fold. A prosthetic valve as described in Section 1. 23. The prosthetic valve of any one of claims 18-22 , wherein the tether comprises sutures sewn to the outer portion of the skirt using skewer stitches. 24. The prosthetic valve of any one of claims 18-23 , wherein the tether comprises an elastic material. 25. The prosthetic valve of any one of claims 18-24 , wherein the tether is one of a plurality of tethers each forming an oblique angle with respect to the fold.