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JPS649986A - Novel phosphocholin derivative - Google Patents

Novel phosphocholin derivative

Info

Publication number
JPS649986A
JPS649986A JP16238387A JP16238387A JPS649986A JP S649986 A JPS649986 A JP S649986A JP 16238387 A JP16238387 A JP 16238387A JP 16238387 A JP16238387 A JP 16238387A JP S649986 A JPS649986 A JP S649986A
Authority
JP
Japan
Prior art keywords
formula
expressed
compound expressed
reacted
phosphocholin
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Pending
Application number
JP16238387A
Other languages
Japanese (ja)
Inventor
Tochirou Tachie
Takashi Takahira
Akira Fujita
Fumi Ishikawa
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Nippon Kayaku Co Ltd
Original Assignee
Nippon Kayaku Co Ltd
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Nippon Kayaku Co Ltd filed Critical Nippon Kayaku Co Ltd
Priority to JP16238387A priority Critical patent/JPS649986A/en
Publication of JPS649986A publication Critical patent/JPS649986A/en
Pending legal-status Critical Current

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  • Pyrane Compounds (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)

Abstract

NEW MATERIAL:A compound expressed by formula I {R<1> is vinyl or ethyl; R<2> is piperiodinoacetyl] or formula II [R<4> is lower alkyl; R<5> is morpholino or formula III (R<6> and R<7> are H or lower alkyl; n is integer of 0-3)]; R<3> is lower alkylcarbonyl and salt thereof. EXAMPLE:6-(2-Morpholinopropionyl)phosphocholin. USE:Heat failure treating agent, antihypertensive agent, cerebral vasodilator, etc., excellent in positive thixotropy inotropic action, adenylyl cyclase activating action, water solubility, etc. PREPARATION:A 7-deacetylphorcholic expressed by formula IV is reacted with a carboxylic acid expressed by the formula R<2>OH to afford a compound expressed by formula V, which is reacted with a base such as triethylamine to provide the compound expressed by formula VI. Then the resultant compound expressed by formula VI is reacted with a carboxylic acid expressed by the formula R<3>OH to give a compound expressed by VII and then acyl at 1-position thereof and R<3> thereof are selectively removed.
JP16238387A 1987-07-01 1987-07-01 Novel phosphocholin derivative Pending JPS649986A (en)

Priority Applications (1)

Application Number Priority Date Filing Date Title
JP16238387A JPS649986A (en) 1987-07-01 1987-07-01 Novel phosphocholin derivative

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
JP16238387A JPS649986A (en) 1987-07-01 1987-07-01 Novel phosphocholin derivative

Publications (1)

Publication Number Publication Date
JPS649986A true JPS649986A (en) 1989-01-13

Family

ID=15753538

Family Applications (1)

Application Number Title Priority Date Filing Date
JP16238387A Pending JPS649986A (en) 1987-07-01 1987-07-01 Novel phosphocholin derivative

Country Status (1)

Country Link
JP (1) JPS649986A (en)

Cited By (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5245052A (en) * 1990-07-23 1993-09-14 Nippon Kayaku Co. Ltd. Process for producing 6-acyl-7-deacetylforskolin derivatives
US5250682A (en) * 1990-07-24 1993-10-05 Hoechst Aktiengesellschaft Process for the preparation of 6-[3-substitutedaminopropionyl]-7-deacetylforskolin derivatives

Cited By (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5245052A (en) * 1990-07-23 1993-09-14 Nippon Kayaku Co. Ltd. Process for producing 6-acyl-7-deacetylforskolin derivatives
US5250682A (en) * 1990-07-24 1993-10-05 Hoechst Aktiengesellschaft Process for the preparation of 6-[3-substitutedaminopropionyl]-7-deacetylforskolin derivatives

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