JPS6473A - Novel aminoacridine derivative - Google Patents
Novel aminoacridine derivativeInfo
- Publication number
- JPS6473A JPS6473A JP62276238A JP27623887A JPS6473A JP S6473 A JPS6473 A JP S6473A JP 62276238 A JP62276238 A JP 62276238A JP 27623887 A JP27623887 A JP 27623887A JP S6473 A JPS6473 A JP S6473A
- Authority
- JP
- Japan
- Prior art keywords
- alkyl
- halogen
- phenyl
- formula
- expressed
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Pending
Links
Landscapes
- Other In-Based Heterocyclic Compounds (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Abstract
NEW MATERIAL:A compound expressed by formula I [R3 is H, alkyl, aralkyl, etc.; (i) R5WR7 are H, halogen, alkyl, phenyl, etc.; in R1WR4, R3' and R4' any two thereof linked to C which is not adjacent is mutually linked to form methylene, ethylene, etc., and the remainder is H, alkyl, phenyl, etc.; (ii) R5 is F, I, NO2, phenyl, etc.; R6 and R7 are H, halogen, CF3, alkyl, etc.; R1WR4, R3 and R4 are H, alkyl, alkoxy, halogen, phenyl, etc.] or acid addition salt thereof.
EXAMPLE: 9-Amino-6-fluoro-1,2,3,4-tetrahydroacridine.
USE: The above-mentioned compound has excellent acetylcholine esterase inhibiting action and useful as a remedy for senile dementia.
PREPARATION: An 2-aminobenzonitrile derivative expressed by formula II (R10WR12 are H, halogen, alkyl, etc.) is reacted with a cyclohexanone derivative expressed by formula III to provide the compound expressed by formula I wherein R8 is H.
COPYRIGHT: (C)1989,JPO&Japio
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| JP62276238A JPS6473A (en) | 1986-10-31 | 1987-10-31 | Novel aminoacridine derivative |
Applications Claiming Priority (4)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| JP26158086 | 1986-10-31 | ||
| JP61-261580 | 1986-10-31 | ||
| JP62-78483 | 1987-03-30 | ||
| JP62276238A JPS6473A (en) | 1986-10-31 | 1987-10-31 | Novel aminoacridine derivative |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| JPH0173A JPH0173A (en) | 1989-01-05 |
| JPS6473A true JPS6473A (en) | 1989-01-05 |
Family
ID=26545141
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP62276238A Pending JPS6473A (en) | 1986-10-31 | 1987-10-31 | Novel aminoacridine derivative |
Country Status (1)
| Country | Link |
|---|---|
| JP (1) | JPS6473A (en) |
Cited By (4)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| JPS63203664A (en) * | 1987-02-13 | 1988-08-23 | ヘキスト・マリオン・ルセル・インコーポレイテツド | 9-amino-1,4-ethano-1,2,3,4-tetrahydroacridine and related compounds |
| JPH01132566A (en) * | 1987-10-05 | 1989-05-25 | Pfizer Inc | 4-aminopyridine derivative |
| JPH032166A (en) * | 1989-05-31 | 1991-01-08 | Mitsubishi Kasei Corp | 9-acylaminotetrahydroacridine derivatives and memory impairment improving agents containing the derivatives as active ingredients |
| US5241345A (en) * | 1990-11-17 | 1993-08-31 | Mita Industrial Co., Ltd. | Optical system-driving device |
-
1987
- 1987-10-31 JP JP62276238A patent/JPS6473A/en active Pending
Non-Patent Citations (1)
| Title |
|---|
| CHEMICAL ABSTRACTS=1989 * |
Cited By (4)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| JPS63203664A (en) * | 1987-02-13 | 1988-08-23 | ヘキスト・マリオン・ルセル・インコーポレイテツド | 9-amino-1,4-ethano-1,2,3,4-tetrahydroacridine and related compounds |
| JPH01132566A (en) * | 1987-10-05 | 1989-05-25 | Pfizer Inc | 4-aminopyridine derivative |
| JPH032166A (en) * | 1989-05-31 | 1991-01-08 | Mitsubishi Kasei Corp | 9-acylaminotetrahydroacridine derivatives and memory impairment improving agents containing the derivatives as active ingredients |
| US5241345A (en) * | 1990-11-17 | 1993-08-31 | Mita Industrial Co., Ltd. | Optical system-driving device |
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