JPS646281A - Benzoxazinorifamycin derivative having alkoxyalkyl group - Google Patents
Benzoxazinorifamycin derivative having alkoxyalkyl groupInfo
- Publication number
- JPS646281A JPS646281A JP63081041A JP8104188A JPS646281A JP S646281 A JPS646281 A JP S646281A JP 63081041 A JP63081041 A JP 63081041A JP 8104188 A JP8104188 A JP 8104188A JP S646281 A JPS646281 A JP S646281A
- Authority
- JP
- Japan
- Prior art keywords
- formula
- benzoxazinorifamycin
- derivative
- expressed
- alkoxyalkyl group
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Pending
Links
- 125000004183 alkoxy alkyl group Chemical group 0.000 title abstract 2
- IXSVOCGZBUJEPI-HTQYORAHSA-N Rifalazil Chemical class CO[C@H]1\C=C\O[C@@]2(C)Oc3c(C)c(O)c4c(c5nc6c(cc(cc6=O)N6CCN(CC(C)C)CC6)oc5c(NC(=O)\C(C)=C/C=C/[C@H](C)[C@H](O)[C@@H](C)[C@@H](O)[C@@H](C)[C@H](OC(C)=O)[C@@H]1C)c4=O)c3=C2O IXSVOCGZBUJEPI-HTQYORAHSA-N 0.000 title 1
- 125000000217 alkyl group Chemical group 0.000 abstract 2
- NUJOXMJBOLGQSY-UHFFFAOYSA-N manganese dioxide Chemical compound O=[Mn]=O NUJOXMJBOLGQSY-UHFFFAOYSA-N 0.000 abstract 2
- 241000894006 Bacteria Species 0.000 abstract 1
- 241000192125 Firmicutes Species 0.000 abstract 1
- 150000001412 amines Chemical class 0.000 abstract 1
- 239000003242 anti bacterial agent Substances 0.000 abstract 1
- 239000008280 blood Substances 0.000 abstract 1
- 210000004369 blood Anatomy 0.000 abstract 1
- 150000001875 compounds Chemical class 0.000 abstract 1
- 239000000463 material Substances 0.000 abstract 1
- 239000007800 oxidant agent Substances 0.000 abstract 1
- HJYYPODYNSCCOU-ODRIEIDWSA-N rifamycin SV Chemical class OC1=C(C(O)=C2C)C3=C(O)C=C1NC(=O)\C(C)=C/C=C/[C@H](C)[C@H](O)[C@@H](C)[C@@H](O)[C@@H](C)[C@H](OC(C)=O)[C@H](C)[C@@H](OC)\C=C\O[C@@]1(C)OC2=C3C1=O HJYYPODYNSCCOU-ODRIEIDWSA-N 0.000 abstract 1
- 150000003839 salts Chemical class 0.000 abstract 1
Landscapes
- Nitrogen And Oxygen Or Sulfur-Condensed Heterocyclic Ring Systems (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Abstract
NEW MATERIAL:A compound expressed by formula I {R<1> represents 2-6C alkoxyalkyl; A represents formula II [a is 2-7; R<2> represents -N(R<3>)R<4>- (R<3> and R<4> represent H or 1-4C alkyl)] or formula III (b and c are 1-4; R<5> represents H or 1-4C alkyl)} or salt thereof. EXAMPLE:4'-Methoxymethylbenzoxazinorifamycin. USE:An antibacterial agent for Gram-positive bacteria and aciduric bacteria, which is adsorbed by oral administration and exhibits high concentration in blood. PREPARATION:A rifamycin derivative expressed by formula IV is reacted with an amine expressed by the formula A-H preferably in the presence of an oxidizing agent such as manganese dioxide.
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| JP63081041A JPS646281A (en) | 1987-03-31 | 1988-03-31 | Benzoxazinorifamycin derivative having alkoxyalkyl group |
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| JP7899387 | 1987-03-31 | ||
| JP63081041A JPS646281A (en) | 1987-03-31 | 1988-03-31 | Benzoxazinorifamycin derivative having alkoxyalkyl group |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| JPS646281A true JPS646281A (en) | 1989-01-10 |
Family
ID=26420034
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP63081041A Pending JPS646281A (en) | 1987-03-31 | 1988-03-31 | Benzoxazinorifamycin derivative having alkoxyalkyl group |
Country Status (1)
| Country | Link |
|---|---|
| JP (1) | JPS646281A (en) |
Cited By (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| KR100407851B1 (en) * | 1997-02-28 | 2004-04-29 | 가네가후치 가가쿠고교 가부시키가이샤 | Treatment of diseases caused by Helicobacter infection |
-
1988
- 1988-03-31 JP JP63081041A patent/JPS646281A/en active Pending
Cited By (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| KR100407851B1 (en) * | 1997-02-28 | 2004-04-29 | 가네가후치 가가쿠고교 가부시키가이샤 | Treatment of diseases caused by Helicobacter infection |
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