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JPS6461426A - Artificial erythrocyte - Google Patents

Artificial erythrocyte

Info

Publication number
JPS6461426A
JPS6461426A JP62215366A JP21536687A JPS6461426A JP S6461426 A JPS6461426 A JP S6461426A JP 62215366 A JP62215366 A JP 62215366A JP 21536687 A JP21536687 A JP 21536687A JP S6461426 A JPS6461426 A JP S6461426A
Authority
JP
Japan
Prior art keywords
inositol hexaphosphate
hemoglobin
liposome
membrane
hemoglobin solution
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Granted
Application number
JP62215366A
Other languages
Japanese (ja)
Other versions
JPH0466456B2 (en
Inventor
Kazuhiko Suzuki
Yoshitaka Ogata
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Terumo Corp
Original Assignee
Terumo Corp
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Terumo Corp filed Critical Terumo Corp
Priority to JP62215366A priority Critical patent/JPS6461426A/en
Publication of JPS6461426A publication Critical patent/JPS6461426A/en
Publication of JPH0466456B2 publication Critical patent/JPH0466456B2/ja
Granted legal-status Critical Current

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/10—Dispersions; Emulsions
    • A61K9/127—Synthetic bilayered vehicles, e.g. liposomes or liposomes with cholesterol as the only non-phosphatidyl surfactant

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Dispersion Chemistry (AREA)
  • Medicinal Chemistry (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Epidemiology (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)

Abstract

PURPOSE:To obtain an artificial erythrocyte having increased quantity of carried oxygen without requiring consideration of blood type in blood transfusion, by incorporating a hemoglobin solution containing an allosteric factor dissolved therein into a liposome. CONSTITUTION:An artificial erythrocyte obtained by adding inositol hexaphosphate which is one of allosteric factors to a hemoglobin solution free of erythrocytic membrane and converting the inositol hexaphosphate into a liposome. The concentration of the hemoglobin solution is preferably 30-60% (wt./wt.) and liposome membrane preferably consists essentially of hydrogenated phospholipid with >=50% hydrogenation ratio. The inositol hexaphosphate is used at 0.8-2 molar ratio based on the hemoglobin. Since the inositol hexaphosphate will not pass through the liposome membrane, the concentration of the inositol hexaphosphate based on the hemoglobin is kept at a constant value to enhance oxygen releasing ability.
JP62215366A 1987-08-31 1987-08-31 Artificial erythrocyte Granted JPS6461426A (en)

Priority Applications (1)

Application Number Priority Date Filing Date Title
JP62215366A JPS6461426A (en) 1987-08-31 1987-08-31 Artificial erythrocyte

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
JP62215366A JPS6461426A (en) 1987-08-31 1987-08-31 Artificial erythrocyte

Publications (2)

Publication Number Publication Date
JPS6461426A true JPS6461426A (en) 1989-03-08
JPH0466456B2 JPH0466456B2 (en) 1992-10-23

Family

ID=16671102

Family Applications (1)

Application Number Title Priority Date Filing Date
JP62215366A Granted JPS6461426A (en) 1987-08-31 1987-08-31 Artificial erythrocyte

Country Status (1)

Country Link
JP (1) JPS6461426A (en)

Cited By (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP0615747A1 (en) * 1993-03-18 1994-09-21 Terumo Kabushiki Kaisha Hemoglobin-encapsulating liposome and method for making the same

Families Citing this family (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JP2010215517A (en) * 2009-03-13 2010-09-30 Terumo Corp Hemoglobin-containing liposome suspension having controlled oxygen affinity to medium oxygen affinity

Citations (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JPS5449314A (en) * 1977-09-06 1979-04-18 Studiengesellschaft Kohle Mbh Improving of oxygen discharging property of erythrocyte
JPS5726621A (en) * 1977-09-06 1982-02-12 Studiengesellschaft Kohle Mbh Blood containing non-injured erythropoesis having improved oxygen-release characteristica
JPS58183625A (en) * 1982-04-02 1983-10-26 ザ・リ−ジエンツ・オブ・ザ・ユニバ−シテイ・オブ・カリフオルニア oxygen delivery system
JPS6137735A (en) * 1984-07-31 1986-02-22 Terumo Corp Hemoglobin-containing liposome and its preparation
JPS62178521A (en) * 1986-01-30 1987-08-05 Terumo Corp Liposome containing hemoglobin

Patent Citations (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JPS5449314A (en) * 1977-09-06 1979-04-18 Studiengesellschaft Kohle Mbh Improving of oxygen discharging property of erythrocyte
JPS5726621A (en) * 1977-09-06 1982-02-12 Studiengesellschaft Kohle Mbh Blood containing non-injured erythropoesis having improved oxygen-release characteristica
JPS58183625A (en) * 1982-04-02 1983-10-26 ザ・リ−ジエンツ・オブ・ザ・ユニバ−シテイ・オブ・カリフオルニア oxygen delivery system
JPS6137735A (en) * 1984-07-31 1986-02-22 Terumo Corp Hemoglobin-containing liposome and its preparation
JPS62178521A (en) * 1986-01-30 1987-08-05 Terumo Corp Liposome containing hemoglobin

Cited By (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP0615747A1 (en) * 1993-03-18 1994-09-21 Terumo Kabushiki Kaisha Hemoglobin-encapsulating liposome and method for making the same

Also Published As

Publication number Publication date
JPH0466456B2 (en) 1992-10-23

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