JPS6450891A - Novel synthesis of phosphosugar derivative - Google Patents
Novel synthesis of phosphosugar derivativeInfo
- Publication number
- JPS6450891A JPS6450891A JP20658287A JP20658287A JPS6450891A JP S6450891 A JPS6450891 A JP S6450891A JP 20658287 A JP20658287 A JP 20658287A JP 20658287 A JP20658287 A JP 20658287A JP S6450891 A JPS6450891 A JP S6450891A
- Authority
- JP
- Japan
- Prior art keywords
- addition reaction
- aryl
- alkyl
- ethylene bond
- phosphorane
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Granted
Links
- 230000015572 biosynthetic process Effects 0.000 title 1
- 238000003786 synthesis reaction Methods 0.000 title 1
- 238000007259 addition reaction Methods 0.000 abstract 4
- 239000005977 Ethylene Substances 0.000 abstract 3
- 125000000217 alkyl group Chemical group 0.000 abstract 3
- 125000003118 aryl group Chemical group 0.000 abstract 3
- 125000002887 hydroxy group Chemical group [H]O* 0.000 abstract 3
- 125000003545 alkoxy group Chemical group 0.000 abstract 2
- -1 phosphorane compound Chemical class 0.000 abstract 2
- 208000030507 AIDS Diseases 0.000 abstract 1
- 125000004423 acyloxy group Chemical group 0.000 abstract 1
- 239000002246 antineoplastic agent Substances 0.000 abstract 1
- 125000004104 aryloxy group Chemical group 0.000 abstract 1
- 239000003795 chemical substances by application Substances 0.000 abstract 1
- 229910052736 halogen Inorganic materials 0.000 abstract 1
- 125000005843 halogen group Chemical group 0.000 abstract 1
- 150000002367 halogens Chemical class 0.000 abstract 1
- 230000003647 oxidation Effects 0.000 abstract 1
- 238000007254 oxidation reaction Methods 0.000 abstract 1
- MPQXHAGKBWFSNV-UHFFFAOYSA-N oxidophosphanium Chemical compound [PH3]=O MPQXHAGKBWFSNV-UHFFFAOYSA-N 0.000 abstract 1
- 239000002994 raw material Substances 0.000 abstract 1
- 229920006395 saturated elastomer Polymers 0.000 abstract 1
- 238000009738 saturating Methods 0.000 abstract 1
Landscapes
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Abstract
PURPOSE:To obtain a phosphorane compound useful for an anticancer agent, anti-AIDS agent, etc., using an inexpensive raw material, by saturating an ethylene bond of a specific phosphorene oxide by addition reaction of hydroxyl group. CONSTITUTION:An ethylene bond of phosphorene oxide expressed by formula I (R<1> is H, OH, alkyl, alkoxyl, aryl or aryloxyl; R<2> and R<3> are H, alkyl or aryl; R<4> is H, OH, alkyl, alkoxyl, aryl, acyloxyl or aryloyloxyl; R<5> is H, C1 unit or C2 unit) is saturated with by at least addition reaction of hydroxyl group to convert the phosphorane oxide to a phosphorane compound expressed by formula II (A is OH or halogen). The saturation of the above-mentioned ethylene bond is preferably carried out by addition reaction of OH group by oxidation or addition reaction of halogen atom and OH by halohydrination.
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| JP20658287A JPS6450891A (en) | 1987-08-21 | 1987-08-21 | Novel synthesis of phosphosugar derivative |
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| JP20658287A JPS6450891A (en) | 1987-08-21 | 1987-08-21 | Novel synthesis of phosphosugar derivative |
Related Child Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP4280070A Division JPH0692426B2 (en) | 1992-10-19 | 1992-10-19 | Method for synthesizing phosphorus sugar derivative |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| JPS6450891A true JPS6450891A (en) | 1989-02-27 |
| JPH0530837B2 JPH0530837B2 (en) | 1993-05-11 |
Family
ID=16525788
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP20658287A Granted JPS6450891A (en) | 1987-08-21 | 1987-08-21 | Novel synthesis of phosphosugar derivative |
Country Status (1)
| Country | Link |
|---|---|
| JP (1) | JPS6450891A (en) |
Cited By (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| JP2008195692A (en) * | 2007-02-15 | 2008-08-28 | National Univ Corp Shizuoka Univ | Phosphorus compounds and antitumor agents |
Citations (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| JPS5615293A (en) * | 1979-07-11 | 1981-02-14 | Hoechst Ag | Manufacture of 11oxophosphoraneechlorohydrins and some special compounds of them |
-
1987
- 1987-08-21 JP JP20658287A patent/JPS6450891A/en active Granted
Patent Citations (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| JPS5615293A (en) * | 1979-07-11 | 1981-02-14 | Hoechst Ag | Manufacture of 11oxophosphoraneechlorohydrins and some special compounds of them |
Cited By (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| JP2008195692A (en) * | 2007-02-15 | 2008-08-28 | National Univ Corp Shizuoka Univ | Phosphorus compounds and antitumor agents |
Also Published As
| Publication number | Publication date |
|---|---|
| JPH0530837B2 (en) | 1993-05-11 |
Similar Documents
| Publication | Publication Date | Title |
|---|---|---|
| GR853064B (en) | ||
| HUT57722A (en) | Process for producing azaspiran derivatives and pharmaceutical compositions comprising such compounds | |
| DE3767351D1 (en) | SIALOSYLCERAMIDES AND METHOD FOR THE PRODUCTION THEREOF. | |
| AU532435B2 (en) | Dental compositions | |
| DE3477488D1 (en) | Polymethoxybenzyl piperazine derivatives, processes for their preparation and pharmaceutical compositions containing said derivatives | |
| IL86080A0 (en) | Bicyclic compounds,processes for preparation thereof and pharmaceutical composition comprising the same | |
| FR2436150A1 (en) | 3 '', 4 '' DERIVATIVES - DIACYLTYLOSINE USEFUL AS MEDICINES | |
| JPS6450891A (en) | Novel synthesis of phosphosugar derivative | |
| GR3006438T3 (en) | ||
| FR2377382A1 (en) | NEW PHENYLAZACYCLOALCANES USEFUL AS MEDICINAL PRODUCTS | |
| FR2384770A1 (en) | NEW QUINAZOLINE DERIVATIVES USEFUL AS MEDICINAL PRODUCTS | |
| ATE49751T1 (en) | PROCESSES AND INTERMEDIATE PRODUCTS FOR THE PREPARATION OF TRANS-4-SUBSTITUTED S-PROLINES. | |
| FR2380271A1 (en) | HALOGEN-BENZOFURANONE-CARBOXYLIC ACIDS USEFUL AS SYNTHESIS INTERMEDIARIES | |
| IE872578L (en) | Antigestagen compositions | |
| DE3471654D1 (en) | Ûbis(hydroxymethyl)-methyl¨-isoquinoline derivatives, process for preparing them and pharmaceutical compositions containing them | |
| CA1273347C (en) | ||
| WO1999029700A3 (en) | Cyclohexadiene-derivatives as pesticides | |
| ZA924888B (en) | Process for the synthesis of enantiomers of 3-aminochroman compounds | |
| GB9203596D0 (en) | Novel process | |
| JPS56125395A (en) | Preparation of acylsilane | |
| JPS5718683A (en) | 3,8-epoxy-7-keto-6-oxabicyclo 3,2,1 octane derivative and its preparation | |
| GB1475616A (en) | Substituted but-2-enoanilides and herbicidal compositions containing them | |
| ES8105335A1 (en) | Process for the preparation of organo-tin trihalides. | |
| JPS55100384A (en) | Cephalosporin analog | |
| MX9702486A (en) | The manufacture of levobupivacaine and analogues thereof from l-lysine. |
Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| S111 | Request for change of ownership or part of ownership |
Free format text: JAPANESE INTERMEDIATE CODE: R313111 |
|
| R350 | Written notification of registration of transfer |
Free format text: JAPANESE INTERMEDIATE CODE: R350 |
|
| EXPY | Cancellation because of completion of term |