JPS6335261A - formulation dosing device - Google Patents

Abstract

(57) [Abstract] This bulletin contains application data before electronic filing, so abstract data is not recorded.

Description

DETAILED DESCRIPTION OF THE INVENTION [Industrial Field of Application] The present invention relates to a drug administration device used for administering solid or semi-solid preparations into the body.

[Prior art]

Methods for treatment by implanting solid drugs into the body are already known. However, the method described in Section 2 generally involves surgery to implant the solid drug into the body.

Therefore, the present applicant has previously proposed a drug administration device that can safely and easily administer solid or semi-solid preparations into the body without surgery (Japanese Patent Laid-Open No. 60-22777
No. 2, JP 60-129057, Patent Application 1982-20
No. 1362, Japanese Patent Application No. 59-204360, etc.).

However, the above-mentioned conventional drug dosing device has a structure in which the drug must be loaded from the rear end of the drug dosing device, so the plunger for pushing out the drug must be removed from the thin tube each time the drug is loaded. Along with the need to escape,
After loading this preparation, a troublesome operation such as reinserting the plunger into the thin tube is required. In particular, since the plunger described above has a long and extremely thin shape, it is not easy to attach or remove it from the iI tube, and there is a risk that the plunger may be accidentally broken when inserted into the thin tube.

When administering the l-1 preparation, it is necessary to hold the tubule in a predetermined state and manually push the plunger until it passes from the rear end of the tubule to the tip.
A considerably large force is required to push out the plunger. Moreover, since the plunger pushing operation described in -I- is done manually, individual differences may occur in pushing out the plunger, which may lead to operational errors such as not being able to push out the plunger properly. In addition, since the preparation is loaded from the rear end of the capillary, the product may be rubbed by internal friction with the capillary while being pushed out from the rear end of the capillary until it passes the tip. There is a risk that the original shape may collapse.

In addition, the above-mentioned drug dosing device has the problem that the container II does not move smoothly because it hits the hanging part of the capillary, and it is not possible to dispense one drug and load it into the capillary. As mentioned above, there is one inside the tubule! ! ! If only one drug can be loaded, it becomes impossible to administer multiple preparations into the body at the same time, and as a result, it is necessary to redo the drug as many times as necessary using a drug dosing device. Moreover, even if a plurality of preparations can be loaded, a correspondingly large push-out force from the plunger is required, making smooth administration of the preparations even more difficult.

C. Purpose of the Invention The present invention has been made in consideration of the above-mentioned conventional problems, and provides excellent operability when administering preparations and easy administration of a plurality of preparations at the same time. The purpose of this invention is to provide a drug administration device that is capable of administering pharmaceutical preparations.

[Structure of the invention]

In order to achieve the above-mentioned purpose, the formulation administering device of the present invention has the following features:
A needle-shaped syringe is removably attached to the front end of a cylinder having a capsule loading hole inside so as to communicate concentrically with the capsule loading hole, while the tip pushes out the preparation in the capsule loading hole. A plunger having an extrusion portion for the purpose is slidably disposed inside the cylinder,
A biasing means for biasing the plunger in the extrusion direction of the preparation is provided, and the extrusion portion of the plunger is moved between a retracted standby position behind the capsule loading hole and a forward extrusion position reaching near the tip 51 of the syringe. By providing a plunger switching means that allows you to switch between the plungers, it improves the operability when administering the preparation. The present invention is characterized in that it is constructed in such a way that it is possible to easily administer a plurality of preparations at the same time.

〔Example〕

An embodiment of the present invention will be described below based on FIGS. 1 to 3.

As shown in FIG. 1, inside the cylinder I there are one or more (two in the illustrated embodiment) protective capsules 3.
A capsule loading hole 1a is formed in the front half of the cylinder 1 so that the capsules can be loaded by arranging them in the axial direction. In this way, by configuring the capsule loading hole 1a so that a plurality of protective capsules 3 can be loaded into the capsule loading hole 1a, a number of protective capsules 3 corresponding to the therapeutic purpose can be simultaneously administered into the body. becomes possible.

As shown in FIG. 2(c), each protective capsule 3 loaded into the capsule loading hole 1a of the cylinder 1 has a solid or semi-solid drug-containing preparation 2 in the capsule body 3a. The capsule body 3a has a structure in which the front and back ends of the capsule body 3a are each covered with a sealing film 3b made of a biocompatible material, thereby sealing the inside of the protective capsule 3. Ga-Nuki falls,
Sterility is ensured so that it is not exposed to the outside air. Further, the capsule body 3a is formed to have a relatively large diameter in order to facilitate handling of the preparation 2, preferably has an outer diameter of 31 or more, and has an inner diameter of, for example, 0.5 to 3.
A dragon with a length of about 5 to 501 weights is used. Further, the material of the capsule body 3a is not particularly limited as long as it does not interact with the drug, but transparent materials such as plastic, polyethylene, silicone, polypropylene, Teflon, etc. are desirable. or,
The material of the sealing film 3b is one that is harmless to the living body, can protect the preparation 2, and can be easily broken (preferably a material with a thickness of 24 mm, such as gelatin, collagen, starch, cellulose, etc.). Examples include albumin and silicon.

A plunger 4 is disposed inside the cylinder 1 so as to be concentric with the cylinder 1. Support members 5, 6 made of rubber or plastic are attached to the outer periphery of the front end of the plunger 4 and the rear portion of the plunger 4 in the longitudinal direction, respectively. The rear support member 6 is fixed to the outer circumferential surface of the plunger 4 and is in sliding contact with the rear inner circumferential surface of the cylinder l. has been done. This allows the plunger 4 to be slidably supported. Further, the rear end flange 4a of the plunger 4 is provided with a
A compression spring 8 is compressed between the cylinder 1 and the inner rear end surface of the cylinder 1. Further, an extrusion portion 4b having a diameter slightly smaller than the inner diameter of the capsule body 3a of the protective capsule 3 is formed at the tip of the plunger 4, and this extrusion portion 4b is formed in the capsule loading hole 1a. It can move forward and backward between the rear part and the vicinity of the needle tip of the syringe 7, which will be described later.

An operating rod 9 is provided in a protruding manner on the plunger 4, and the operating rod 9 passes through an elongated hole regulating portion 10 formed in the cylinder 1 and projects to the outside of the cylinder 1. As shown in FIG. 2(b), the elongated hole regulating portion 1o includes a plunger movement guide hole 10a extending in the axial direction of the cylinder 1.
and a plunger standby stopper hole 10b extending in the circumferential direction from the rear end of the plunger movement guide hole 10a. The operating rod 9 and the elongated hole regulating section 10 constitute a plunger switching means 11. The plunger movement guide hole 10a of this plunger switching means 11 is
The extrusion part 4b of the plunger 4 is connected to the capsule loading hole 1a.
The operating rod 9 is set to be movable between a rear retraction standby position and a forward push-out position reaching near the needle tip of the syringe 7, which will be described later, and that the operating rod 9 is located in one hole 10b of the plunger standby stopper which forms the retraction standby position. Depending on the position, the forward movement of the plunger 4 is restricted, and the structure is such that these can be selectively switched.

On the other hand, a syringe 7, which can be attached to and detached from the cylinder 1 concentrically, is attached to the front end of the cylinder 1 in a protruding manner to prevent it from being accidentally pulled out of the cylinder 1. . The cylindrical shaft has a needle tube shape and is concentrically connected to the capsule loading hole 1a. I will be treated. The syringe 7 has a sharp tip, and a mounting member 7a is fitted and fixed to the outer periphery of the rear end so that the syringe 7 can be attached to and detached from the cylinder l. ” 1. The mounting member 7a is
As shown in FIG. 2(a), an oval collar portion 7b is formed at the rear end. On the other hand, as shown in FIG. 2(b), the front end of the cylinder 1 is formed with an oval opening 1b into which the flange 7b of the syringe 7 can be fitted, and furthermore, The flange portion 7b is located deep inside the circular opening 1b.
A perfectly circular fitting hole 1c is formed having an inner diameter slightly larger than the maximum outer diameter. The oval opening 1b and the fitting hole 1c are formed concentrically with the capsule loading hole 1a. In addition, in the protruding state of the syringe 7 in which the collar portion 7b of the syringe 7 is fitted into the fitting hole 1c, the rear end hole of the syringe 7 is connected to the capsule loading hole 1c.
a, and the peripheral edge of the rear end hole is connected to the formulation 2.
It serves as a stopper 70 for preventing the capsule and body 3a from being pulled out at the same time when the capsule 3a is pushed out.

The solid or semi-solid formulation 2 has medicinal components held in a biocompatible carrier. The method for manufacturing the protective capsule 3 containing the solid preparation 2 is not particularly limited, but for example, a mixed solution of a medicinal ingredient and a carrier is freeze-dried, then pulverized, and the resulting powder is compressed. A method is employed in which a solid preparation in the form of a rod, needle, or sphere is obtained by molding, and the solid preparation is loaded into the capsule body 3a. Alternatively, after kneading the medicinal ingredient and carrier with an appropriate amount of water or buffer, dry a rod or needle obtained by injection molding, etc., and cut it into an appropriate length.
It may also be folded and then placed inside the capsule body 3a. On the other hand, in the case of semi-solid preparation 2, the manufacturing method is not particularly limited; can be obtained.

To give a concrete example of the dimensional relationship among the above constituent members, the syringe 7 has a length of 20 to 150 mm and an inner diameter of 0.5 to 150 mm.
Approximately 3 mm, Formulation 2 has a length of 5 to 50 m1, and a diameter of 0.5 to
The length of the capsule body 3a of the protective capsule 3 is about 3 mm.
~501, inner diameter about 0.5 to 3 mm, cylinder 1 has a length of about 20 to 200 mm, and plunger 4 has a length of 25 mm.
~200 mm and a diameter of about 0.5~311 mm. The cylinder 1 and plunger 4 may be made of, for example, glass, non-corrosive metal, or synthetic resin such as plastic, but these materials may be used in combination.

In the case of glass and non-corrosive metals, they can be reused through sterilization treatment, but in the case of synthetic resins, they are often disposable after only one use.

In the configuration described in -, when administering the solid or semi-solid preparation 2 in the capsule body a into the body, first, the required number of protective capsules 3 are removed from the sterile packaging.

On the other hand, the syringe 7 attached to the front end of the cylinder 1
are removed in advance, and the protective capsules 3 are loaded into the capsule loading hole 1a from the front end side of the cylinder 1, that is, from the oval opening 1b side, and are arranged in the axial direction. Thereafter, the syringe 7 is attached to the front end of the cylinder 1 again. To install this syringe 7, install the syringe 7.
This is done by inserting the flange 7b from the oval opening 1b of the cylinder 1 while matching their shapes, and then rotating the syringe 7 by about 90 degrees inside the fitting hole IC. Next, as shown in FIG. 3, after puncturing the needle tip of the syringe 7 into the body to the required depth, while fixing the cylinder 1 with your fingers, insert the tip of the operating rod 9 protruding from the cylinder 1. The plunger is moved in the circumferential direction to release the plunger from the plunger standby stopper hole 10b. Then, the plunger 4 is pushed out in the axial direction with a constant pressure by the action of the compression spring 8, and the push-out portion 4b of the plunger 4 pushes out the protective capsule 3...
The preparation 2... is pushed out at 1ffiL through the inside of the capsule body 3a while breaking through the sealing membrane 3b. At this time, the capsule body 3a of the protective capsule 3 placed in the front hits the stopper 7C of the syringe 7, so it remains inside the capsule loading hole 1a. Each of the above formulations 2
... is administered into the body by passing through the inside of the syringe 7 i times by the extrusion action of the extrusion portion 4b of the plunger 4 which is further 41 'It. Note that a portion of the seal membrane 3b will be transferred into the body together with the preparation 2.

Thereafter, the needle tip of the syringe 7 is removed from the body.

〔Effect of the invention〕

As described below, in the pharmaceutical administration device of the present invention, a needle-shaped syringe is detachably attached to the front end of a cylinder having a capsule loading hole therein so as to communicate concentrically with the capsule loading hole. While the capsule is attached, a plunger having a push-out portion at its tip for pushing out the preparation in the capsule loading hole is slidably disposed inside the cylinder, and urging means for urging the plunger in a direction to extrude the preparation. In addition, a plunger switching means is provided for selectively switching the extrusion portion of the plunger between a retracted standby position at the rear of the capsule loading hole and a forward extrusion position reaching near the needle tip of the syringe. As a result, the preparation is administered into the body using a constant extrusion pressure using the urging means, so manual extrusion is not required when pushing the plunger.

Therefore, there are no individual differences in the pushing force of the plunger,
The plunger push-out operation is performed smoothly, so
Administrative operability is improved and the risk of operational errors is eliminated. Moreover, since the operation of loading the protective capsule into the capsule loading hole of the cylinder is performed from the front end side of the cylinder after removing the syringe from the cylinder, the administration operability of the pharmaceutical dosing device is further improved. This not only eliminates the need for the troublesome and difficult operation of removing and removing the plunger, but also avoids breakage of the plunger. Furthermore, since the capsule loading hole is formed in the front part of the cylinder, the amount of movement of the preparation during administration is reduced, making it difficult for the original shape of the preparation to lose its shape, and smooth movement of the preparation is ensured. Ru. In addition, even if the capsule loading hole is set to a size that allows a plurality of protective capsules to be loaded therein, the biasing means for the plunger and the plunger switching means Since the extrusion of the preparation is carried out under a constant pressure, it also has the advantage that a plurality of preparations can be administered into the body simultaneously and easily.

[Brief explanation of the drawing]

1 to 3 show an embodiment of the present invention, in which FIG. 1 is a longitudinal sectional view, FIG. 2(a) is a perspective view of a syringe, and FIG.
b) is a perspective view of a state in which the syringe is removed from the preparation administering device, FIG. 3(C) is a perspective view of the protective capsule, and FIG. 1 is a cylinder, 1a is a capsule loading hole, 1b is an oval opening, IC is a fitting hole, 2 is a formulation, 3 is a protective capsule, 3a
is a capsule body, 3b is a sealing membrane, 4 is a plunger, 4b
is an extrusion part, 5 and 6 are supporting members, 7 is a syringe, 7b is a collar part, 7C is a stopper, 8 is a compression spring (biasing means), 9
10 is an operating rod, 10 is a long hole regulating portion, ]Oa is a plunger movement guide hole, 10b is a hole for a plunger standby stopper, and 11 is a plunger switching means.

Claims (1)

[Claims] 1. A needle-shaped syringe is removably attached to the front end of a cylinder having a capsule loading hole inside so as to communicate concentrically with the capsule loading hole. A plunger having an extrusion portion for extruding the drug is slidably disposed inside the cylinder, and biasing means for urging the plunger in the extrusion direction of the preparation is provided, and the extrusion portion of the plunger is inserted into the capsule loading hole. 1. A pharmaceutical dosing device, characterized in that a plunger switching means is provided for selectively switching between a rear retreat standby position and a forward pushing position reaching near the needle tip of the syringe.