JPS6322024A - Rejuvenation of human body by tissue transplantation of new genes in cell nuclei and juvenile whole cells - Google Patents
Rejuvenation of human body by tissue transplantation of new genes in cell nuclei and juvenile whole cellsInfo
- Publication number
- JPS6322024A JPS6322024A JP61163447A JP16344786A JPS6322024A JP S6322024 A JPS6322024 A JP S6322024A JP 61163447 A JP61163447 A JP 61163447A JP 16344786 A JP16344786 A JP 16344786A JP S6322024 A JPS6322024 A JP S6322024A
- Authority
- JP
- Japan
- Prior art keywords
- cells
- new
- life
- rejuvenation
- genes
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Pending
Links
- 210000004027 cell Anatomy 0.000 title claims abstract description 45
- 210000001519 tissue Anatomy 0.000 title claims abstract description 15
- 108090000623 proteins and genes Proteins 0.000 title claims abstract description 13
- 238000002054 transplantation Methods 0.000 title claims abstract description 9
- 230000003716 rejuvenation Effects 0.000 title claims abstract description 8
- 210000003855 cell nucleus Anatomy 0.000 title abstract description 6
- 230000000366 juvenile effect Effects 0.000 title abstract 2
- 210000000633 nuclear envelope Anatomy 0.000 claims abstract description 6
- 230000035755 proliferation Effects 0.000 claims abstract description 3
- 210000005132 reproductive cell Anatomy 0.000 claims abstract 3
- 210000004940 nucleus Anatomy 0.000 claims abstract 2
- 238000000034 method Methods 0.000 claims description 13
- 230000001605 fetal effect Effects 0.000 claims description 10
- 238000006243 chemical reaction Methods 0.000 claims description 4
- 210000003754 fetus Anatomy 0.000 claims description 4
- 210000000056 organ Anatomy 0.000 claims description 4
- 210000004291 uterus Anatomy 0.000 claims description 4
- 210000004602 germ cell Anatomy 0.000 claims description 3
- 238000012258 culturing Methods 0.000 claims description 2
- 235000013601 eggs Nutrition 0.000 claims 2
- 238000000338 in vitro Methods 0.000 claims 1
- 210000001082 somatic cell Anatomy 0.000 claims 1
- 239000003163 gonadal steroid hormone Substances 0.000 abstract description 4
- 239000000122 growth hormone Substances 0.000 abstract description 4
- 238000002347 injection Methods 0.000 abstract description 4
- 239000007924 injection Substances 0.000 abstract description 4
- 102000018997 Growth Hormone Human genes 0.000 abstract description 3
- 108010051696 Growth Hormone Proteins 0.000 abstract description 3
- 230000017531 blood circulation Effects 0.000 abstract 1
- 210000004204 blood vessel Anatomy 0.000 abstract 1
- 230000000694 effects Effects 0.000 abstract 1
- 239000005556 hormone Substances 0.000 description 3
- 229940088597 hormone Drugs 0.000 description 3
- 230000024245 cell differentiation Effects 0.000 description 2
- 230000018109 developmental process Effects 0.000 description 2
- 239000004606 Fillers/Extenders Substances 0.000 description 1
- 230000032683 aging Effects 0.000 description 1
- 230000003409 anti-rejection Effects 0.000 description 1
- 230000004888 barrier function Effects 0.000 description 1
- 210000000601 blood cell Anatomy 0.000 description 1
- 210000000133 brain stem Anatomy 0.000 description 1
- 230000008822 capillary blood flow Effects 0.000 description 1
- 239000002775 capsule Substances 0.000 description 1
- 238000004113 cell culture Methods 0.000 description 1
- 230000010261 cell growth Effects 0.000 description 1
- 230000004069 differentiation Effects 0.000 description 1
- 230000012010 growth Effects 0.000 description 1
- 229960003444 immunosuppressant agent Drugs 0.000 description 1
- 239000003018 immunosuppressive agent Substances 0.000 description 1
- 238000012606 in vitro cell culture Methods 0.000 description 1
- 239000003094 microcapsule Substances 0.000 description 1
- 210000000653 nervous system Anatomy 0.000 description 1
- 230000001902 propagating effect Effects 0.000 description 1
- 230000002792 vascular Effects 0.000 description 1
Landscapes
- Medicines Containing Material From Animals Or Micro-Organisms (AREA)
Abstract
Description
【発明の詳細な説明】
本案は老人の老化した細胞組織に若々しい細胞を移植し
て若返りを図る発案で、先に発明者が特許出願第６１−
０８７７４５． ［単性生殖細胞培養移植による不老
延命法］において記述した発明を更に発展させたもので
発明相互に関連を有するものであります。以下前述の順
に従って説明します。Detailed Description of the Invention This invention is an idea to rejuvenate an elderly person by transplanting youthful cells into the aging cell tissue, and the inventor previously filed a patent application No. 61-
087745. This invention is a further development of the invention described in [Method of prolonging life to old age through unisexual germ cell culture transplantation], and the inventions are related to each other. The following will be explained in the order listed above.
（１）延命しようとする人の生殖細胞を２個づつ合体さ
せて単性生殖を行い、これを培養・増殖させて。(1) To prolong life, the germ cells of the person are combined in pairs to achieve unisexual reproduction, which are then cultured and multiplied.
その新細胞核の遺伝子を核膜に入ったまま抽出し。The genes from the new cell nucleus are extracted while still in the nuclear envelope.
これをもとの延命者の古い細胞組織内に注入して。This is injected into the old cell tissue of the original life extender.
新しい遺伝子をもった新細胞組織を拡大して人体の若返
りを果す方法で、必要に応じて細胞分化ホルモン、成長
ホルモン及び性ホルモンをマイクロカプセル又は分子カ
プセルに封入して遺伝子核膜移植と同時、同場所に移植
して新細胞の増殖を促進するようにします。細胞核遺伝
子の移植方法として注射針、血管流特に毛細血管の血流
を利用する方法及びジェットインジエツクションによる
噴射法等を活用いたします。細胞核は細胞に比べて小さ
く、移植しやすい利点があります。新細胞核は延命者の
体内のとこえでも注入することが可能です。This is a method of rejuvenating the human body by expanding new cell tissue with new genes. Cell differentiation hormone, growth hormone, and sex hormones are encapsulated in microcapsules or molecular capsules as needed, and the gene nuclear membrane is transplanted at the same time. Transplant in the same location to encourage new cell growth. As a method for transplanting cell nuclear genes, we use methods such as injection needles, methods that utilize vascular flow, especially capillary blood flow, and injection methods using jet injection. Cell nuclei are smaller than cells and have the advantage of being easier to transplant. New cell nuclei can be injected even inside the body of a person whose life is being extended.
（２）延命者の単性授精細胞を女性の子宮内又は人工子
宮内或いは体外細胞培養によって増殖させて。(2) Unisexual fertilized cells of life-extending individuals are grown in the woman's uterus, in an artificial uterus, or by in vitro cell culture.
胎芽期及び胎児期にある約１０ケ月間の新細胞核遺伝子
・単性胎児細胞及び胎児細胞組織或いは胎児臓器、胎児
脳神経系細胞、胎児を髄細胞・血液系細胞その他全部を
取り出して区分して、もとの延命者の体内の対応する各
部分に移植・注入し。New cell nuclear genes, unisexual fetal cells, fetal cell tissues or fetal organs, fetal brain and nervous system cells, pulp cells, blood system cells and all other parts of the fetus during about 10 months in the embryonic and fetal stages are removed and separated. It is transplanted and injected into the corresponding parts of the body of the person whose life was extended.
必要に応じて新細胞の増殖促進のため前記のように細胞
分化ホルモン、成長ホルモン、性ホルモンその他を同時
移植して新細胞組織の拡大を急速に行うことにより人体
の若返り長寿を実現する方法です。This is a method to achieve rejuvenation and longevity of the human body by simultaneously transplanting cell differentiation hormone, growth hormone, sex hormone, etc. as described above to promote the proliferation of new cells as necessary, and rapidly expand new cell tissue. .
（３）人体内にその人と異る第三者の細胞を移植した場
合に必ず拒絶反応が起ってその細胞は育つことができま
せん。しかし最近優れた免疫抑制剤やモノクロナール抗
体法による拒絶反応抑制技術が進歩して間もなく拒絶反
応は自在に制御される見通しです。(3) When cells from a different person are transplanted into the human body, a rejection reaction will always occur and the cells will not be able to grow. However, with the recent advances in anti-rejection technology using superior immunosuppressants and monoclonal antibody methods, it is expected that rejection will soon be controlled.
拒絶反応の完全抑制が成功した場合は上記（１）、（２
）の単性授精細胞の代りに任意の第三者の両性授精細胞
を培養増殖して、（イ）その新細胞核（核膜・遺伝子）
の延命者への移植、（ロ）新細胞全体の延命者への移植
、い）胎児期約１０ケ月内における胎児全体細胞の延命
者の体内えの移植、及び（ニ）胎児出生後の幼児期より
成人期までの約２０年前後の間の幼若全体細胞を延命者
の体内の対応する各部分に注入、移植することがスムー
ズに可能となります。If the rejection reaction is completely suppressed, the above (1) and (2)
) by culturing and propagating bisexual fertilized cells of any third party in place of the unisexual fertilized cells of (a) the new cell nucleus (nuclear envelope/gene).
(b) Transplantation of whole new cells into a life-extending person, (b) Transplantation of whole fetal cells into the body of a life-extending person within about 10 months of the fetal period, and (d) Infant after birth of the fetus. It becomes possible to smoothly inject and transplant whole immature cells from about 20 years, from childhood to adulthood, into corresponding parts of the body of a person whose life is being extended.
移植した新細胞の発育・成長を促進するため成長ホルモ
ン、分化ホルモン、性ホルモンを活用することは（１）
、 （２）と同様です。The use of growth hormones, differentiation hormones, and sex hormones to promote the development and growth of transplanted new cells is (1)
, Same as (2).
人間の寿命は今のところ平均８０才近くなっていますが
１本案は若い新細胞を次々と移植して新細胞組織を拡大
することにより寿命の壁を突破しようとする有意義な発
明です。The average human lifespan is currently close to 80 years, but this project is a meaningful invention that attempts to break through the lifespan barrier by expanding new cell tissue by transplanting young new cells one after another.
Claims (3)
殖を行い、これを培養、増殖した後、その新細胞の核（
遺伝子、核膜）を分離抽出して、もとの延命者の体内各
部分の老化した細胞組織内に注入移植して新細胞組織を
拡大することによる若返り延命法。(1) Carry out unisexual reproduction of two reproductive cells of a person whose life is to be extended, and after culturing and multiplying them, the nucleus of the new cell (
A rejuvenation and life extension method that involves separating and extracting genes (genes, nuclear membranes) and injecting and transplanting them into aged cell tissues in various parts of the body of the original person to expand new cell tissues.
培養において増殖して、胎芽期・胎児期にある約１０ケ
月間の新細胞核遺伝子・単性胎児細胞・細胞組織・胎児
臓器その他全部を取り出し区分して、もとの延命者の体
内の対応する各部分に移植して同種の新細胞組織を拡大
することを特長とする若返り延命法。(2) The unisexual fertilized cells of life-extending individuals are proliferated in the woman's uterus or other in vitro culture, and the new cells are in the embryonic/fetal stage for approximately 10 months including genes, unisexual fetal cells, cell tissues, fetal organs, etc. This rejuvenation and life extension method is characterized by extracting the entire body, dividing it into sections, and transplanting it into corresponding parts of the body of the original person to expand the same type of new cell tissue.
と他の異性の生殖細胞を両性受精した受精卵を子宮内又
は体外において細胞培養した後、延命者に（イ）新細胞
の核（核膜付遺伝子）を移植する、（ロ）新細胞全体の
移植、（ハ）胎児期にある全細胞組織、器管、臓器の移
植、（ニ）胎児出生後の幼児期より成人期までの若々し
い各細胞の移植を行い増殖させることを特色とする不老
長寿法。 更に拒絶反応が完全制御された場合に任意の第三者の両
性授精卵を用いて上記（イ）（ロ）（ハ）（ニ）と同様
な方法により延命者の体細胞若返りを果すことを特長と
する不老延命法。(3) On the premise of suppressing rejection reactions, the fertilized eggs are bisexually fertilized with reproductive cells of the person whose life is being extended and germ cells of the other opposite sex, and the cells are cultured in the uterus or outside the body. (b) transplantation of whole new cells, (c) transplantation of all cell tissues, organs, and organs in the fetal stage, (d) from infancy to adulthood after the birth of the fetus. A longevity method that features the transplantation and proliferation of youthful cells. Furthermore, when the rejection reaction is completely controlled, somatic cell rejuvenation of the life-extending person can be carried out using the same method as in (a), (b), (c), and (d) above using a bisexually fertilized egg from any third party. Features of life extension method.
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| JP61163447A JPS6322024A (en) | 1986-07-11 | 1986-07-11 | Rejuvenation of human body by tissue transplantation of new genes in cell nuclei and juvenile whole cells |
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| JP61163447A JPS6322024A (en) | 1986-07-11 | 1986-07-11 | Rejuvenation of human body by tissue transplantation of new genes in cell nuclei and juvenile whole cells |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| JPS6322024A true JPS6322024A (en) | 1988-01-29 |
Family
ID=15774053
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP61163447A Pending JPS6322024A (en) | 1986-07-11 | 1986-07-11 | Rejuvenation of human body by tissue transplantation of new genes in cell nuclei and juvenile whole cells |
Country Status (1)
| Country | Link |
|---|---|
| JP (1) | JPS6322024A (en) |
Cited By (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US7238673B2 (en) | 1989-03-31 | 2007-07-03 | The Regents Of The University Of Michigan | Treatment of diseases by site-specific instillation of cells or site-specific transformation of cells and kits therefor |
-
1986
- 1986-07-11 JP JP61163447A patent/JPS6322024A/en active Pending
Cited By (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US7238673B2 (en) | 1989-03-31 | 2007-07-03 | The Regents Of The University Of Michigan | Treatment of diseases by site-specific instillation of cells or site-specific transformation of cells and kits therefor |
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