JPS63126817A - Cosmetic composition - Google Patents

Abstract

PURPOSE:To obtain a cosmetic composition having excellent ultraviolet light absorption ability, effective for preventing erythema, etc., on the skin, having neither irritation nor toxicity to hair, skin, etc., containing a dehydroamino acid derivative or a benzalhydantoin derivative. CONSTITUTION:A cosmetic composition containing 0.1-20wt%, preferably 0.5-10wt% compound shown by formula I (B is H or acetyl; X1-X3 are H, OH or methoxy; Y is O or NH; Z is methyl or phenyl; R is 3-18C alkyl, cyclohexyl or trimethylcyclohexyl), such as N-benzoyl-O-methyl-alpha-dehydrotyrosine isopropyl ester or compound shown by formula II (W is H or CH2CH2CO2R: R is H, 1-18C alkyl, cyclohexyl or trimethylcyclohexyl), such as 4- benzylidene-2,5-dioxo-1-imidazolidinepropionic acid n-butyl ester. The compound has large absorption effect at 240-400nm.

Description

DETAILED DESCRIPTION OF THE INVENTION Field of Industrial Application The present invention relates to an ultraviolet absorbing cosmetic composition containing at least one of a dehydroamino acid derivative and a benzalhydantoin derivative.

BACKGROUND OF THE INVENTION Ultraviolet rays are known to cause various changes to the skin. In dermatology, ultraviolet rays are defined as long-wavelength ultraviolet rays (4
00-320nm), medium wavelength ultraviolet rays (320-290nm)
m), short wavelength ultraviolet rays (divided into 290 to 10100 nm, and called UV-A, UV-B, and UV-C, respectively).

Of these, UV-C is absorbed by the ozone layer and almost never reaches the ground. In addition, when UV-B is irradiated to the skin in excess of a certain amount, it may cause erythema, blisters, etc.
It is known to cause pigmentation. On the other hand, U
It has conventionally been said that VA does not cause much change in the skin. However, it has recently been found from electron microscopy and histological evaluation that UV-A causes changes in elastic fibers in blood vessel walls and connective tissues. Furthermore, it causes damage to sensitive skin and skin that is constantly exposed to solar radiation. Also, U V-A Hashi TV-B
It has also been reported that it promotes the effects of
, Will is,
A, Kl i g man, and
J, Epstein"Photo-enhance
ment”The Journal.

f Investigative Dermato
logy vol. 59 no. 6 p. 416 1973), U
Shielding VA is just as important as shielding UV-B.

As the UV-B absorber, benzophenone absorbent, salicylic acid absorbent, cinnamic acid absorbent, paraaminobenzoic acid absorbent, etc. are used. However, among the above-mentioned ultraviolet absorbers, there are very few that combine effectiveness, safety, solubility, stability, etc.

Furthermore, the history of research on LrV-A is short, and there are not many substances known that effectively absorb UV light when used repeatedly on the skin. At present, only a few dibensoylmethane derivatives, cinnamic acid derivatives and chalcone derivatives are known. (West German Patent Publication No. 2728241
No. 2728243, Japanese Patent Publication No. 51-61641,
No. 52-46056, No. 57-59840, No. 57
(No. 197209, No. 60-109544) In addition to the above-mentioned ultraviolet absorbers, inorganic powders such as titanium dioxide, zinc oxide, and iron oxide, which have the function of physically reflecting and scattering ultraviolet rays, are also used.

Problems to be Solved by the Invention As mentioned above, various ultraviolet absorbers have been developed, but they differ in terms of ultraviolet absorption ability, safety, solubility in solvents and resins,
The reality is that no one has yet been found that satisfies all of these requirements, and there is a desire for ultraviolet absorbers and cosmetic compositions that have excellent ultraviolet absorbing ability, safety, and stability.

Benzophenone absorbers have the effect of absorbing long wavelength ultraviolet rays of 320 to 400 nm, but what about medium wavelength ultraviolet rays (290 to 320 nm), which are thought to be the cause of blisters?
On the other hand, the absorption capacity is relatively low.

Para-aminobenzoic acid-based and cinnamic acid-based absorbents have a high absorption effect, but are said to have stability problems. Also,
Salicylic acid-based absorbents have a weak absorption effect and cannot be expected to be effective unless added in large quantities.

On the other hand, inorganic powders have the problem of being limited in the types of cosmetics that can be blended with them, and coloring when blended in large amounts.

Means for Solving the Problems In view of the above-mentioned circumstances, the present inventors have conducted intensive research and found that the α-dehydroamino acid derivative represented by the following general formula (1) and the benzene represented by the general formula (2) are As shown in Tables 1 and 2, the zarhydantoin derivatives are 240~
It has a large absorption effect at 400 nm and contains various animal and vegetable oils,
It was found that it is easily soluble in oils and fats and 82 drugs. Cosmetic compositions containing at least one of these compounds have good ultraviolet absorption ability, are effective in preventing skin erythema, have excellent light and thermal stability, and are effective against skin and lips. The present invention was completed based on the discovery that it is neither irritating nor toxic to hair, nails, etc.

OYR (1).

(However, B is a hydrogen atom or an acetyl group.
, X2, and x3 are either a hydrogen atom, a hydroxyl group, or a methoxy group, and two or three of these may be the same at the same time, or all may be different. Y is an oxygen atom or an amino group (-NH-). Z is a methyl group,
Or a phenyl group. R is an alkyl group of 03 to C+s, a cyclohexyl group, or a trimethylcyclohexyl group. ) l 'vVN NCH2CH2C02R++
(2) Either an acid group or a methoxy group, two or three of which may be the same at the same time, or all may be different. W is a hydrogen atom or -CH=-CH2C
It is 02R. R is a hydrogen atom, an alkyl group having 1 to 18 carbon atoms, a cyclohexyl group, or a trimethylcyclohexyl group. ) The present invention also provides a method of protecting human epidermis, hair, lips, and nails against solar radiation. it is,
The object of the present invention is to apply a cosmetic composition containing at least one of the compounds represented by formulas (1) and (2) to the skin, hair, lips, and nails.

Urylamide, N-benzoyl-0-methyl-α-dehydrotyrosine isopropyl ester, N-benzoyl-O-methyl-α-dehydrotyrosine lauryl ester, N-benzoyl-O-methyl-α-dehydrotyrosine stearyl ester, N-benzoyl -〇-Methyl-α-dehydrotyrosine 2-ethylhexyl ester, N-benzoyl-0-methyl-α-dehydrotyrosine cyclohexyl ester, N-benzoyl-0-methyl-α-dehydrotyrosine 3.3, δ-trimethylcyclohexyl ester, N-7 cetyl-0-methyl-α-
Dehydrotyrosine isopropyl ester, N-acetyl-〇-methyl-α-dehydrotyrosine 2-ethylhexyl ester, N-acetyl-〇-methyl-α-dehyto' rotyrosine lauryl ester, N-acetyl-〇-methyl-α-dehydrotyrosine stearyl ester, N-acetyl-N-benzoyl-0-methyl-α-dehydrotyrosine n-butyl ester, N-a7tyl-N-benzoyl-0-methyl-α-dehydrotyrosine isopropyl ester, N-acetyl-N-benzoyl-0- Methyl-α-dehydrotyrosine 2-ethylhexyl ester, N-acetyl-N-benzoyl-0-
Methyl-α-dehydrotyrosine lauryl ester, N
-Acetyl-N-benzoyl-〇-methyl-α-dehydrotyrosine stearyl ester, N,N-diacetyl-〇-methyl-α-dehydrotyrosine n-butyl ester, N,N-diacetyl-〇-methyl-α-dehydrotyrosine isopropyl ester , N,N-diacetyl-〇-methyl-α-dehydrotyrosine 2-ethylhexyl ester, N,N-diacetyl-〇-methyl-α-dehydrotyrosine lauryl ester, N,N-diacetyl-〇-methyl-α-dehydrotyrosine stearyl ester , N-benzoyl-3,4,5-trimethoxy-α-dehydrophenylalanine Two examples are: 4-benzylidene-2,5-dioxo-1
, 3-imidazolidine dipropionic acid, 4-benzylidene-2,5-dioxo-1,3-imidazolidine dipropionic acid diisopropyl ester, 4-benzylidene-
2,5-dioxo-1,3-imidazolidine dipropionic acid di-n-butyl ester, 4-benzylidene-2,5
-dioxo-1,3-imidazolidine dipropionic acid diisobutyl ester, 4-benzylidene-2,5-dioxo-1,3-imidazolidine propionic acid bis(2-
ethylhexyl ester), 4-benzylidene-2,5
-Dioxo-1-imidazolidine propionic acid, 4-henzylidene-2,5-dioxo-1-imidazolidine propionic acid isopropyl ester, 4-benzylidene-
2,5-dioxo-1-imidazolidine propionic acid isobutyl ester, 4 ++ J, ndylidene-2.5
-dioxo-1-imidazolidine propionic acid isobutyl ester, 4-benzylidene-2,5-dioxo-1
-Imidazolidine propionic acid 2-ethylhexyl ester, 4-(3,4-dimethoxyphenyl)methylene-
2,5-dioxo-1,3-imidazolidine dipropionic acid, 4-(3,4-dimethoxyphenyl)methylene-
2,5-dioxo-1,3-imidazolidine dipropionic acid dimethyl ester, 4-(3,4-dimethoxyphenyl)methylene-2,5-dioxo-1,3-imidazolidine dipropionic acid diethyl ester, 4- (3,4
-dimethoxyphenyl)methylene-2,5-dioxo-
L 3-imidazolidine dipropionic acid diisopropyl ester, 4-(3,4-dimethoxyphenyl)methylene-2,5-dioxo-1,3-imidazolidine dipropionic acid dibutyl ester, 4-(3,4-dimethoxy phenyl)methylene-2,5-dioxo-1,
3-Imidazolidine dipropionic acid diisobutyl ester, 4-(3,4-zine)xyphenyl)methylene-
2,5-dioxo-1,3-imidazolidine dipropionic acid bis(2-ethylhexyl ester), 4-(3,
4-dimethoxyphenyl)methylene-2,5-dioxo-1-imidazolidinepropionic acid, 4-(3,4-dimethoxyphenyl)methylene-2,5-dioxo-1-
imidazolidine propionic acid isopropyl ester, 4
-3,4-dimethoxyphenyl)methylene-2,5-
Dioxo-1-imidazolidine propionic acid methyl ester, 4-(3,4-dimethoxyphenyl)methylene-
2,5-dioxo-1-imidazolidine propionic acid ethyl ester, 4-(3,4-dimethoxyphenyl)methylene-2,5-dioxo-1-imidazolidine propionic acid isobutyl ester, 4-(3,4-dimethoxy phenyl)methylene-2,5-dioxo-1-imidazolidine propionic acid isobutyl ester, 4-(3,
4-dimethoxyphenyl)methylene-2,5-dioxo-1-imidazolidine propionic acid 2-ethyl l\゛xyl ester, 4-(4-methoxyphenyl)methylene-2,5-dioxo-1-imidazolidine propionate acid ethyl ester, 4-(3,4,5-trimethoxyphenyl)methylene-2,5-dioxo-1-imidazolidine propionic acid ethyl ester, and the like.

The cosmetic composition in the present invention has the above general formula (1) or/
The compound represented by (2) and the conventionally used known components, that is, an oil phase component and/or an aqueous phase component or/
and a powder component and/or a surfactant component that emulsifies, disperses, and solubilizes these components.

Examples of known components used in this process include beeswax, wood wax, spermaceti, carnauba wax, candilla wax, cacao butter, cetyl alcohol, stearyl alcohol, oleic acid, and stearin. Acid, lanolin, olive oil, camellia oil, cottonseed oil,
Synthesis of animal and vegetable oils such as castor oil, oleyl alcohol, and squalane, mineral oils and fats such as solid paraffin, ceresin, microglysterine wax, petrolatum, liquid baraf, in, and silicone oil, and isopropyl myristate and synthetic polyethers. Examples include oils and fats. In addition, water phase components include glycerin, propylene glycol, sorbitol, polyethylene glycol, quince seed gum, trangum pum, alginate, pectin, carboxymethylcellulose, hyaluronic acid, water-soluble chitin, polyvinyl alcohol, ethanol, isopropanol, citric acid. , urea, cationized cellulose fatty acid polypeptide condensate, lactic acid, pyrrolidone carboxylate, various amino acids, and the like. Examples of surfactants that can be used include polyoxyethylene fatty acid partial ester, polyoxyethylene sorbitan fatty acid partial ester, polyoxyethylene glycene fatty acid partial ester,
Nonionic surfactants such as polyglycerin fatty acid partial ester, fatty acid alkanolamide, fatty acid alkanolamide ethylene oxide adduct, polyoxyethylene glycerin fatty acid, pyroglutamic acid monoglycerin ester, acylglutamic acid glycerin ester, alkyl sulfate-1, polyester, etc. Oxyethylene alkyl sulfate, fatty acid amide ether sulfate, alkylbenzene sulfonate, alkyloxysulfonate, sulfosuccinic acid higher alcohol ester salt, N-
Long chain fatty acid acyl-N-methyltaurine salt, fatty acid salt,
Anionic active agents such as N-long chain acyl glutamate, N-long chain acyl sarcosine salt, monoalkyl phosphate, carboxybetaine type, imidacillin type, lecithin, aminosulfonic acid type, alkylamine oxide type, Nα, Nα- dimethyl or amphoteric active agents such as Nα, Nα, Nα-trimethyl-Nε-acyl basic amino acids;
Examples include cationic activators such as dialkyldimethylammonium chloride, argyltrimethylammonium chloride, and fatty acid acylarginine ethyl ester salt. In addition, powder components include talc, kaolin, titanium dioxide, titanium-coated mica, mica, iron oxide, silicic acid, ultramarine,
Examples include inorganic powders such as navy blue, zinc white, clay, and precipitated calcium carbonate, and organic powders such as N-mono long chain acyl basic amino acids.

Furthermore, these cosmetic compositions contain commonly used cosmetic auxiliaries such as thickeners, softeners, wetting agents, supergreasing agents, emollients, wetting agents, preservatives, antifoaming agents, fragrances, and the composition itself. or may contain dyes and/or fragrances to provide skin coloration, or any other ingredients commonly used in cosmetics.

The cosmetic composition of the present invention can take any form such as a solution, emulsion, kneaded mixture, solid (blessed product), powder, etc. by adjusting the types and amounts of each of the above-mentioned components. is possible. In addition, the cosmetic composition of the present invention can be used in sun oil, lotion, cream, emulsion, hair rinse, hair conditioner, liquid foundation, lipstick, foundation,
These include white powder, air vines, etc.

The content of the compounds of general formulas (1) and (2) in the cosmetic composition of the present invention varies depending on the formulation and required sun protecting factor (SPF), but is generally 0. It is 1 to 20% by weight, preferably 0.5 to 10% by weight.

You can also use some of these in the morning. Furthermore, at least one of the compounds of general formulas (1) and (2) may be used in combination with other ultraviolet absorbers.

Examples of the ultraviolet absorbent that can be passed through this are P-methylbenzylidene-D, L-camphor or its derivatives such as sulfonic acid sodium salt, 2-phenylbenzimidazole-5-sulfonic acid sodium salt, 3. Benzophenones such as 4-dimethylphenylglyoxylate sodium salt, 4-phenylbenzophenone-2-carboxylic acid isooctyl ester, p-methoxycinnamic acid ester, 2-phenyl-5-methylbenzoxasol, 2-ethylhexyl salicylate ester or ρ-dimethylaminobenzoic acid esters.

The light shielding agent can also be produced from easily available industrial starting materials such as inorganic powder aromatic aldehydes such as titanium dioxide and acrylic esters.

Effects of the Invention The α-dehydroamino acid derivative represented by the general formula (1) and the benzalhydantoin derivative represented by the general formula (2) have a large absorption effect in the wavelength range of 240 to 400 nm, and are effective against various animal and vegetable oils, fats and oils, and organic solvents. It is also easily soluble. Among the benzalhydantoin derivatives of the general formula (2), those in which X2 is a hydroxyl group or a methoxy group have large absorption in the long wavelength region (320 to 400 nm), and can be used in various animal and vegetable oils, fats and oils, and organic Soluble in the agent. These α-dehydroamino acid derivatives and benzalhydantoin derivatives have good ultraviolet absorption ability, excellent light and thermal stability, and are non-irritating and non-toxic substances for the skin, hair, and mucous membranes. It is. Therefore, by blending 0.1 to 20% of these compounds depending on the application, cosmetic compositions such as various oils, lotions, creams, milky lotions, hair rinses, hair conditioners, liquid foundations, lipsticks, foundations, white powders, aerosols, etc. Able to offer and offer things.

Next, for typical compounds according to the present invention, if the maximum absorption wavelength (λl·) and molar extinction coefficient (εas.) are
Other physical property values are summarized in Tables 1 and 2 as Example 1. Further, although typical formulation examples are shown in Example 2 and subsequent examples, the present invention is not limited to these examples.

Example 2 Sun oil A sun oil was prepared by blending the following composition according to a conventional method.

More advantageous conditions for homogenizing the following composition are about 40 to 4
Mix while heating to 5°C.

N-acetyl-N-benzoyl 10-methyl-α-dehydrothi 4% by weight Rosin 2
-Ethylhexyl ester ゛Cacao butter 2.5% fragrance
0. 5% by weight fatty acid triglyceride 93% by weight (08-Cl2) Example 3 Skin protection cream (0/W type) Components (A) and (B) were dissolved by heating according to the following composition. After mixing both, the mixture was cooled to room temperature to prepare a skin protection cream.

(A) 4-(3,4-dimethoxyphenyl)methylene-2,5-dioxo-1,3-imidazolidine 8 times% dipropionic acid diethyl ester N, N-diacetyl-〇-methyl-α-dehydrotyrosine I 8% by weight Sobropyl ester fatty acid triglyceride 10% by weight (Cl to Co
2) Cetyl alcohol 1.5% by weight polyoxyethylene cetyl nityl and polyoxyethylene stearyl ether 6% by weight (10E, O
) Polyoxyethylene sorbitan monostearate 2% by weight (20E, O
,) (B) Glycerin 1.5% by weight propylene glycol 1. 5% by weight sorbitol solution (70%) 3.5% by weight pyrrolidone carboxylic acid sodium salt 0. 5% by weight methyl paraoxybenzoate 0.2% by weight water
5763% by weight Example 4 Skin protection cream (W2O type) The following composition was used in Example 3.
A skin protection cream was prepared according to the same method as above.

(A) N-benzoyl-〇-methyl-α-dehydrotyrosine 2-functional 8% by weight tylhexyl ester cetyl alcohol 1. 5% by weight honey
1.5% by weight paraffin oil
Triple weight % cholesterol
1% by weight fatty acid triglycerides 8% by weight
(Co~Cl2) Glyceryl monostearate 5% by weight Sorbitan monopalmitate 9% by weight Polyoxyethylene sorbitan monostearate 1% by weight (20E, O
,) Ceresin 5% spermaceti by weight
2% by weight propyl paraoxybenzoate 0. 11ili% (B) Glycerin 1. 5% by weight propylene glycol 1.5% by weight sorbitol solution (70%) 4-base% methyl paraoxybenzoate
0.2% water by weight
47.7% by weight Example 5 Sunmilk (emulsion) The following composition was blended in the same manner as in Example 3 to prepare Sunmilk.

(A) 4-benzylidene-2,5-dioxo-1,3-imidazolidine dibro and diisopropyroic acid 5% by weight ester 4-(3,4-dimethoxyphenyl)methylene-2,5-dioxo-1-imidazolidine 2-ethylhexyl propionate 2% by weight Ester polyoxyethylene cetyl nityl and stearyl ether 5% by weight (10E, 0
．． ) Vaseline oil 6% by weight Isopropyl myristate 3% by weight Silicone oil
1% by weight cetyl alcohol 1% by weight preservative appropriate amount fragrance
Appropriate amount of water Balance Example 6 Sunmilk (emulsion) The following composition was blended in the same manner as in Example 3 to prepare Sunmilk.

(A) 4-benzylidene-2,5-dioxo-1-imidazolidine propionic acid isopropyl ester 5% by weight liquid paraffin 22.6% by weight solid paraffin 4.5% by weight cetanol
4% by weight sorbitan monostearate
1. 8 weight 1 t% polyoxyethylene sorbitan monostearate 2.8 weight % (20E
, O,) Nε-cocoyl ornithine 5% by weight (B) Pyrrolidonecarboxylic acid triethanolamine salt 4% by weight water
50.1% by weight preservative 0. 2ffi amount% Example 7 Sunscreen lotion According to the following composition, component (A) was heated and dissolved, and after cooling to room temperature, component (B) was added to prepare a sunscreen lotion.

(A) 4-Benzylidene-2,5-dioxo-1,3-imidazolidine dipropionic acid dinatrium 2% by weight Salt glycerin 5% by weight Polyethylene glycol 4000.5% by weight Fragrance
Appropriate amount of water Balance (B) 96% ethanol 40% critical Example 8
Lipstick A lipstick was prepared according to the following composition.

A part of (B) was added to (A) and treated with a roller to form a pigment part. A hot melt of (B) was added to this, treated with a homogenizer to make it uniform, rapidly cooled and solidified, and then shaped.

(A) Titanium dioxide 2% by weight N-benzoyl-〇-methyl-α-dehydrotyrosine Isobu 5.7% by weight ester (B) Hexadecyl alcohol 25% by weight Lanolin
4M member% honey butterfly
5% by weight Osokerite 4% Candelilla fly 7% by weight Carnauba butterfly 2% by weight Antioxidant
Appropriate amount of fragrance Appropriate amount of castor oil Balance Example 9 Oil-based sun gel An oil-based sun gel was prepared by heating a fatty substance at 40 to 45°C according to the following composition, adding silica while stirring, and cooling.

N-benzoyl-O-methyl-α-dehydrotyrosine lauri 3% by weight ester p-methoxycinnamic acid 2-ethylhexyl ester 2% by weight cocoa butter
2.5% by weight silica
10% by weight Antioxidant Appropriate amount Flavor Appropriate amount Fatty acid triglyceride Balance (C8-Cl
2) Example 10 Foaming air spray 90 parts of a mixture having the following composition and Freon gas (F21/F
114=40/60) was charged into a pressure container to prepare a foaming air spray.

4-Benzylidene-2,5-dioxo-1-imidazolidine propionic acid Isopropyl varnish 0.3% tristearic acid 7% by weight Propylene glycol 7% by weight Triethanolamine
6% by weight olive oil 2% by weight water Balance Example 11
Non-foaming lotion air spray mixture 3 with the following composition
0 parts and freon gas (F21/Fl 14=40/6
0) 70 parts were charged into a pressure container and used as a non-foaming lotion air spray.

N-acetyl-〇-methyl-α-dehydrotyrosine Isopro 1% Biel Ester Propylene Glycol 10% FFI 99% Ethanol 30% Water
Balance Example 12 Foundation According to the following composition, (C) was mixed and heated at 70°C to dissolve (oil phase). Separately, mix and dissolve (B) and keep at 70°C (aqueous phase)
. After dispersing (A) in the aqueous phase, an oil phase is further added to emulsify it,
A foundation was obtained by cooling.

(A) 4-benzylidene-2,5-dioxo-1-imidazolidinepropionic acid n-butyl ether 10% polydispersity stellate titanium oxide 6% by weight Red iron oxide
1.5% by weight yellow iron oxide
0. 2% by weight (B) N-lauroylglutamic acid monomagnesium salt 0. 5% by weight triethanolamine 1. Quadruple f1% propylene glycol 9.5% water
37.9% by weight (C) Stearic acid 2.8% by weight Propylene glycol monostearate 2.8% by weight Glyceryl monostearate 2.8% by weight (self-emulsifying type) Liquid paraffin 24.6% by weight Example 1
3 White powder White powder was obtained by mixing according to the following composition.

N-benzoyl-〇-methyl-α-dehydrotyrosine 72. 4ffi amount% laurylamide talc 10% by weight titanium oxide 1% by weight kaolin
5% by weight Nε-lauroyl lysine 5
Weight% zinc laurate -1.8% by weight
Iron oxide (red, yellow, black) 1.8% by weight Fragrance 3% by weight Example 14
Rinse According to the composition below, heat and dissolve (A') at 80°C, then add and disperse (B). Add (C) previously dissolved at 80℃ to it and mix and emulsify.
It was cooled to room temperature and a rinse was prepared.

(A) 4-(3,4-dimethoxyphenyl)methylene-2,5-dioxo-1,3-imidazolidine 1% by weight dipropionate disodium salt cation O5 (Note 1) 1% by weight CAE (
Note 2) 0.5% by weight polyoxyethylene sorbitan monooleate 0. 5% by weight (4E
,0. ) Polyoxyethylene sorbitan monooleate 0.5% by weight (25E
,O,) Water 89.5
Weight % (B) Nε-lauroyl lysine 2 weight % (C) Liquid paraffin 2 weight % cetanol
3! ffi% (Note 1) Sanyo Chemical (
(Note 2) Ajinomoto Co., Inc.

Claims (1)

[Scope of Claims] A cosmetic composition comprising at least one compound represented by the following general formulas (1) and (2). ▲There are mathematical formulas, chemical formulas, tables, etc.▼(1) (However, B is a hydrogen atom or an acetyl group.X_
1, X_2, and X_3 are either a hydrogen atom, a hydroxyl group, or a methoxy group, and two or three of these may be the same at the same time, or all may be different. Y is an oxygen atom or an amino group (-NH-). Z is a methyl group or a phenyl group, R is C_3 to C_1_8
an alkyl group, a cyclohexyl group, or a trimethylcyclohexyl group. ) ▲There are mathematical formulas, chemical formulas, tables, etc.▼(2) (However, in general formula (2), X_1, X_2, and X_3 are either hydrogen atoms, hydroxyl groups, or methoxy groups, and two or three of these are Even if they are the same at the same time,
Everything can be different. W is a hydrogen atom or -CH_
2-CH_2CO_2R. R is a hydrogen atom, an alkyl group having 1 to 18 carbon atoms, a cyclohexyl group, or a trimethylcyclohexyl group. )