JPS6299318A - Hair tonic - Google Patents

Abstract

PURPOSE:A hair tonic, containing an extract of glossy privet as a roborant and tonic of a herb medicine as an active constituent, safe for the human body without skin irritation and having very remarkable trichogenous and hair growth promoting action. CONSTITUTION:A hair tonic obtained by using an extract prepared by extracting pulverized glossy privet (fruit of Ligustrum japonicum Thunb. or Ligustrum lucidum Ait. of the family Oleaceae) with a solvent, e.g. methanol or n-hexane, etc. The above-mentioned extract is preferably incorporated in an amount of 0.1-5wt% expressed in terms of a dried material in a hair tonic composition. When the hair tonic is applied to human or animal skin, very remarkable trichogenous and hair growth promoting effect is exhibited.

Description

DETAILED DESCRIPTION OF THE INVENTION The present invention relates to a hair tonic, and more specifically to a hair tonic.
) as an active ingredient.

Hair tonics containing various medicinal agents have long been known, and their effects include promoting blood circulation in the scalp, activating hair matrix cells, and suppressing the secretion of lipids in the scalp. There are many examples of ingredients that include amino acids and vitamins. Examples of these medicinal agents include vitamins such as vitamin E1 and pantothenic acid, amino acids such as methionine and serine, bactericidal agents such as salicylic acid, resorcinol, and hinokitiol, hormones such as ethinyl estradiol, vasodilators such as acetylcholine derivatives, Examples include skin function enhancers such as 771 Lantin. Hair tonics containing these medicinal agents are said to be effective in preventing and improving dandruff, itching, and hair loss, and to promote hair growth and growth, but the current situation is that none of them are satisfactory.

On the other hand, substances used as hair nourishing agents are required to have excellent hair nourishing effects and to be particularly safe since they are used continuously over a relatively long period of time. ′ As a result of intensive search and research for substances that exhibit even more superior hair growth and hair growth effects, the present inventors applied extracts (extract components) in various solvents of Onna Sadako, which is known as a herbal medicine, to the skin of humans or animals. The present invention was completed based on the discovery that when applied, it has extremely significant hair growth and hair growth promoting effects.

That is, the present invention relates to a hair nourishing agent characterized by containing an extract of female damsel.

The female Sadako used in the present invention is a mouse mochi (L.
igua 廿un japonicum Thunb,
) and lucidum Ai (L, lucidum Ai
ton) and is used as a tonic tonic in Chinese medicine. Mannitol, ursolic acid, oleanolic acid, and acetyl oleanolic acid have been found in the fruits, and components such as nonacosanol, β-sitosterol, and lupeol have been found in the seeds.

The extract used in the present invention is obtained by finely pulverizing commercially available female filth, and then using a water-soluble solvent such as methanol, ethanol, water, etc., or an organic solvent such as ethyl acetate, n-hexane, or chloroform. Extracted alone or in combination. As a dry matter, the extract of the female Sadako is usually 0.01 to 15% by weight, preferably 0.1 to 5% by weight, based on the total weight of the hair tonic composition (prescribed ingredients).
It is appropriate to mix them. If the amount f is less than 0.01% by weight, a sufficient effect cannot be obtained, and if the amount exceeds 15% by weight, the effect will not be enhanced, which is uneconomical.

Either case is fine. When blended into a base material such as a hair tonic, the female extract may be used in a dry state, or the extract itself may be used.

The female virgin extract of the present invention is in the form of a liquid or paste, is safe for the human body, and does not cause skin irritation. A sample of the female virgin extract dispersed in white petrolatum at 1 and 5% by weight is prepared according to the method of Draize. A growth stimulation test was conducted on animals, and a 48-hour occlusive patch test was conducted on humans using a combination of Finn chamber and Scanball tape. As a result, all scores were 0, confirming that there was no skin irritation.

The hair tonic of the present invention can be used in the form of hair lotions, hair creams, hair tonics, tinctures, lotions, ointments, etc., along with base materials for various cosmetics, pharmaceuticals, etc., according to conventional methods.

In the present invention, the extract of Onna Sadako may be used alone, but for example, if it is used in combination with the extracts of Kokatsu, Toshi, Senega, Ishiko, and Mulberry parasitic, which are known as herbal medicines, the The same level of or slightly better hair growth effect was obtained. One or more extracts of these herbal medicines can be used in combination with an extract of female pedophile.

Hereinafter, the effectiveness of the hair tonic of the present invention will be explained with reference to Examples. Note that the content of the present invention is not limited to these. In the Examples, parts refer to parts by weight, and % refers to % by weight.

Example 1 After finely crushing 100 f of Onna Sadako (commercial product), it was immersed in 400-proof ethanol, heated to reflux for 2 hours, and then heated under reduced pressure at p.
pass The residue was further heated and extracted with 400 tons of ethanol, and then subjected to reduced pressure. The P liquids were combined and concentrated and dried under reduced pressure to obtain the female Sadako ethanol extract (yield: 10-15 liters).
get. The obtained extract 52 was dissolved in 95f of ethanol to prepare a hair growth test sample for the hair growth agent of the present invention. By the same method, vertical hexane extract, ether extract, 50
Test samples such as % ethanol extract, water extract, etc. were prepared.

Test Example 1 The experimental animals were engineered OR mice (male, 16 weeks old, 1 average body weight, 2
Using clippers, the entire abdomen from the back to both sides was removed using clippers. Starting from the next day, the extract of the present invention was applied to the skin of the test site twice a day in the morning and evening at a dose of 0.1 ml per animal. There were 6 animals in each group, and a sample was applied to the right flank of the experimental animals, and ethanol was applied to the left flank as a control. The hair growth state was determined by comparing the evaluation scores determined with the naked eye. The hair growth effect was judged according to the criteria shown in Table 1, and the average value of 6 animals was used as an index.

After the start of the experiment, on the 20th day and the 30th day of clogging, visual judgment was made according to the criteria shown in Table 1, and the average evaluation score per animal was determined. The results of these experiments are summarized in Table 2.

Table 2: Effect of hair growth on mice by the extract of the female child of the present invention. Its effectiveness as a drug was recognized.

Test Example 2 After removing the entire back and both sides of the abdomen with clippers, the hair was removed using depilatory cream.
The hair growth effect was evaluated using the average body weight of 20 g. In the same manner as in Test Example 1, the extract of the female pedophile of the present invention was applied to the skin of the test area of mice twice a day, in the morning and evening, in an amount of α1 ml per mouse. A group of six animals was used, and teethanol was applied to the right flank as a sample and as a control to the left flank. Taking the case of applying the ethanol extract of female Sadako as an example, 2.4.7 and 1
FIG. 1 shows the results of sampling the new hairs generated from the hair removal site on day 0 and measuring the body hair length.

Body hair length was measured using the method of ToMsdiaina et al.
l Plant Research, Supplsme
nt, P84.1980).

In other words, any 20 samples sampled with the solid microscope
The actual hair was measured. Five of the longest hairs were selected from among the 20 hairs measured, and the average value was determined to be the body hair length of the mouse. As shown in Figure 1, compared to the control group (ethanol application group), the group to which the 1st female Sadako extract was applied,
It showed a significant hair growth promoting effect.

Example 3 Hair tonic 095% ethanol 60.0 parts Female Sadako ethanol extract 2.0 ■ Glycerin 2.0 ■ Purified water
36.0 [Manufacturing method] Ingredients (1) to (2) are thoroughly stirred and mixed, and after passing, the product is packed in a container.

Example 4 Hair cream ■ Stearic acid 4.0 parts ■ Cetyl alcohol 3.0 ■ Stearyl alcohol 1.0 ■ Liquid paraffin
6.5 ■Vaseline
10.0 1□ ■Sorbitan monostearate 1.5■0”
0"2'y(25)ゝ'" [Tearley]
s, o
i■ Female Sadako-ta-~ Extract 1. .
[■Glycerin
15.0 [Phase] Ihipotassium hydroxide. ,2
1゛:1 ◎Preservative appropriate amount
:◎Purified water °“°′”
) [Manufacturing method] Ingredients ■～■ and ingredients ■～@ respectively
[h7o~75'Ct. □Eng, □4O. ~
Ingredients (1) to (1) are added to (1) and emulsified, and the mixture is cooled to 30°C to form a product.

Example 5 Hairlow silane ■ Stearic acid 5.0 parts ■ Heptyl alcohol 5.0 ■ Liquid paraffin 2.0 ■ Gly7rin monostearate) 1.5 II) Il
l■Sorbitan monoole) 1.5
1 ■ Polyoxyethylene (io) sorbitan monooleate 0.8 ■ Female Sadako ether extract 1.0 ■ Glycerin 6.0 ■ Preservative
Appropriate amount of O purified water
77.4 [Manufacturing method] Proceed in the same manner as in Example 4 to obtain a product.

Example 6 Ointment ■ Purified lanolin 5.0 parts ■ White beeswax S, O ■ Sadako extract 2.0 ■ Vaseline
88.0 [Manufacturing method] After heating and melting each component and mixing, the product is cooled.

Figure t Hair growth promotion effect Procedural amendment’IF (method) %formula% 2 Name of the invention hair tonic 3 Person making the amendment January 28, 1986 5 Target of correction Column for brief description of drawings in specification 6 Contents of amendment

[Brief explanation of drawings]

FIG. 1 is a diagram showing the relationship between the hair length and the number of test days in the case of applying female pedigree extract, which is a component of the hair growth agent of the present invention, and ethanol as a control.

Claims (1)

[Claims] A hair tonic characterized by containing an extract of Sadako.