JPS6254784A - Aerosol composition - Google Patents

Abstract

PURPOSE:To obtain the titled composition which has no tackiness, does not drip, and, on spraying, forms foam which makes a cracking sound due to foam breakage, consisting of a specified stock solution and a propellant composed mainly of dichlorotetrafluoroethane. CONSTITUTION:100pts.wt. aqueous ethanol and/or isopropyl alcohol solution (a) of a concentration of 3-60wt% is mixed with 0.01-10pts.wt. surface active agent (b) (e.g., a polyoxyethylene alkyl ether) and/or 0.1-50pts.wt. powder of talk, nylon, etc., (c), and 0.1-50pts.wt. effective component (d) according to application, such as a perspiration control, hair tonic, astringent, body lotion, itch relief, germicide or hair treatment component to give a stock solution. 2-30pts.wt. said solution is mixed with 98-70pts.wt. propellant comprising dichlorotetrafluoroethane as the principal component and containing, if necessary, dichlorofluoromethane, etc.

Description

[Detailed description of the invention] [Industrial application field] The present invention relates to aerosol compositions.

[Conventional technology]

Traditionally, there have been aerosol products such as those that spray the active ingredient in the form of a mist, such as hair spray, and those that spray the active ingredient in the form of a foam, such as shaving cream. 32
A composition for producing a pressurized foam that produces a crackling sound by subjecting the foam to shear when the user rubs the foam ejected from an aerosol product onto the skin layer with his/her hand as described in US Pat. No. 053. Things are being developed.

[Problems that development attempts to solve]

However, the conventional pressurized compositions for foam production as described above form emulsions by shaking water with the water-insoluble oil components present in the cosmetically active ingredients, and are used for a long period of time. If not used, the water and oil components will separate, requiring strong shaking or long-term shaking each time to uniformly disperse the water and oil components, as well as a large amount of water. If the user rubs the sprayed foam on their skin with their hands,
There is a problem with slow drying on the skin.

Therefore, the present inventors conducted extensive research to solve the above problems, and found that ethanol and/or ethanol, which can easily and uniformly disperse oil-based active ingredients that are insoluble in water and have excellent quick-drying properties, The inventors have discovered that the above problems can be solved by using isopropyl alcohol, and have completed the present invention.

[Means to solve the problem]

The present invention uses 0.01 to 10131 parts of surfactant and/or 0.1 part of powder per 100 parts by weight of ethanol and/or isopropyl alcohol 3 to 60% aqueous solution.
Aerosol consisting of ~50 parts by weight, 2 to 30 parts by weight of a stock solution with addition of 0.1 to 50 parts by weight of the active ingredient, and 70 to 98 parts by weight of a propellant whose main component is dichlorotetrafluoroethane. Regarding the composition.

〔Example〕

The alcohol aqueous solution used in the present invention is ethanol and/or
Alternatively, it consists of an aqueous solution of 3 to 60% (mold mouth %, the same shall apply hereinafter) of isopropyl alcohol, preferably 10 to 40%.

Ethanol and isopropyl alcohol are soluble in water-soluble components and various organic compounds that are insoluble in water, so they are used as solubilizers or dispersants for both of these components, but ethanol and isopropyl alcohol have low boiling points. Because it evaporates easily, it is useful as a component for quick-drying and cooling sensations.Furthermore, ethanol and isopropyl alcohol have excellent foam-breaking properties, making them useful as components that make the sound of foam-breaking louder. .

In addition, if the f degree of the alcohol aqueous solution is less than 3%, it will be difficult for the water-insoluble oily active ingredient to disperse uniformly with the aqueous component, and drying will be slow; if it exceeds 60%, dichlorotetrafluoroethane (hereinafter referred to as Freon 114), the compatibility with propellants whose main component is too high, resulting in less foaming and no crackling sound when sprayed, so use in the range of 3 to 60%. is preferable.

The surfactant used in the present invention is a component for uniformly dispersing the stock solution and the propellant, and includes, for example, polyoxyethylene alkyl ether, polyoxyethylene polyoxypropylene alkyl ether, polyoxyethylene alkylphenyl ether, Examples include surfactants such as polyoxyethylene castor oil derivatives, but are not limited to these as long as they can be dispersed.

The surfactant is added in an amount of 0.01 to 10 parts, preferably 0.01 to 100 parts of a 3 to 60% aqueous solution of ethanol and/or isopropyl alcohol (molding department, hereinafter the same).
It is used by adding 1 to 5 parts. If the amount added is less than 0.01 parts, strong shaking or long-term shaking will be required to uniformly disperse the stock solution and propellant, and if it exceeds 10 parts, the surfactant itself will become sticky. This is not desirable as it may cause discomfort.

The powder used in the present invention may be any powder that is difficult to dissolve in water, ethanol and/or isopropyl alcohol, and a propellant whose main components are Freon 114, but it is particularly preferable to use talc, nylon, etc., which have a shaping effect. is preferred.

The powder is used by adding 0.1 to 50 parts, preferably 1 to 30 parts, to a 60% aqueous solution of ethanol and/or isopropyl alcohol.

If the amount added is less than 0.1 part, the effect of obtaining an emulsion by shaking the water component and oil component will be small;
If the amount exceeds 50 parts, powder may remain on the skin after the pressurized composition is sprayed onto the skin and dried, which is not preferable.

For example, when an emulsion is prepared by shaking the water and oil components using talc in the range mentioned above,
It has the same effect as a surfactant or enhances the effect of a surfactant, and in some cases, the emulsion can be dispersed by simple shaking without using a surfactant.

The active ingredients used in the present invention are selected according to various uses, and include, for example, antiperspirant active ingredients, hair tonic active ingredients, aftershave lotion active ingredients, hand lotion active ingredients, astringent active ingredients, and acne lotion active ingredients. Ingredients include, but are not limited to, suntan lotion aerosol active ingredients, body lotion active ingredients, repellent active ingredients, anti-itch active ingredients, anti-inflammatory analgesic active ingredients, bactericidal active ingredients, etc., but are not limited to these. components can be used.

The active ingredient is 0.1 parts per 100 parts of a 3-60% aqueous solution of ethanol and/or isopropyl alcohol.
~50 parts, preferably 1 to 30 parts, is used.

If the amount added is less than 0.1 part, it will not be effective for the intended use, and if it exceeds 50 parts, it will be difficult to disperse the active ingredient, which is not preferred.

As mentioned above, the stock solution used in the present invention can be changed by adding a surfactant and an active ingredient to an aqueous alcohol solution. Monohydric alcohols such as and their denatured alcohols: Polyhydric alcohols such as propylene glycol, ethylene glycol, diethylene glycol, triethylene glycol, glycerin: Ketones such as acetone, methyl ethyl ketone, methyl isobutyl ketone Ni diethyl ether, ethylene glycol monoethyl ether Ethers such as isopropyl myristate, isopropyl palmitate, butyl myristate, and esters such as mustard oil. In addition, liquid paraffin, kerosene, xylene, kerosene, etc. may be added.

Next, the aerosol composition of the present invention can be obtained by preparing the stock solution and the propellant.

By the way, the crackling sound of bubbles ejected from an aerosol product is due to the rapid evaporation of the propellant trapped in the bubbles, causing the bubbles to burst. There's a loud noise.

In order for the injected foam to burst with a crackling sound, it is preferable that the boiling point of the propellant is in the range of -5°C to 5°C. It is preferable that the main component is Freon 114, which does not liberate hydrogen halide in the presence of water and does not corrode the metal container for aerosol.
Dimethyl ether or even Freon 114 alone has a low vapor pressure, so it may be pressurized with N2, CO2 or air, and dichlorodifluoromethane (hereinafter referred to as Freon 12), which is a nonflammable gas with a high vapor pressure, is used in combination. Good too. As a specific example, Freon 114 100-7
5 parts and vapor pressure at 20°C is 0.8-8.0Kt
/d propellant consisting of 0 to 25 parts of liquefied petroleum gas: 100 to 70 parts of Freon 114 and 0 to 70 parts of dimethyl ether
Examples include a propellant consisting of 30 parts of chlorofluorocarbons = 100 to 70 parts of chlorofluorocarbons and a propellant consisting of 120 to 30 parts of chlorofluorocarbons. In addition, if compressed gas is used together, 8 phantom /
Although a product pressure range of 7 or less can be used, various other propellants can also be used.

The stock solution/propellant is used in a weight ratio of 2798 to 30/7G. If the mixing ratio is less than 2798, there is a limit to the amount of active ingredients that can be added, and there is a problem with the dispersibility of the stock solution and propellant. Even if the foam bubbles, the crackling sound will not be produced, which is not desirable.

Next, the present invention will be explained in more detail using Examples, but the present invention is not limited to these Examples.

Example 1 (Antiperspirant) 3.5 parts of 99% geraniol-denatured ethanol, 10 parts of pure water
．． 0 part, Epan 740 (manufactured by Daiichi Kogyo Seiyaku ■) as a surfactant, 0.5 part, O rubidroxyaluminum 0.2 part as an antiperspirant active ingredient, and Irgasan 0P-300 (Ciba Geigy) as a bactericidal active ingredient. ), 2.6 parts of talc as an excipient, and Freon 11483 as a propellant.
An antiperspirant aerosol composition was prepared by filling 0 parts into an aerosol pressure-resistant container and attaching an aerosol valve and button.

The physical properties of the resulting aerosol composition, such as dispersibility, foam adhesion, drying properties, and bubble bursting sound, were investigated using the following methods. The results are shown in Table 1.

(Dispersibility) The dispersibility of the aerosol composition was examined when the aerosol composition was subjected to F51 20 times with a width of about 50α, and evaluated according to the following criteria.

(Judgment criteria) ○: An emulsion was formed and uniformly dispersed. ×: Separated into two phases and not uniformly dispersed (foam adhesion) The aerosol composition was sprayed on approximately 3C11 squares of the arm. The presence or absence of dripping was observed, and the foam adhesion of the aerosol composition was examined and evaluated according to the following criteria.

(Judgment criteria) O: No dripping Δ: Slight dripping ×: Dripping (bubble bursting sound) Spray the aerosol composition on about 3 cm square of the arm and crush the sprayed bubbles by hand. The presence or absence of bubble breaking sound was investigated using the following method, and evaluation was made according to the following criteria.

(Judgment criteria) ○: There is a bubble breaking sound △: There is a slight bubble breaking sound ×: Drying without a bubble breaking sound) The aerosol composition is sprayed on about 3 crtt square of the arm,
After the sprayed foam was crushed by hand, it was left to stand for 1 minute, and the dryness on the surface of the arm was observed and evaluated according to the following criteria.

(Judgment Criteria) O: Feels rough to the touch Δ: Feels slightly damp to the touch ×: Feels slimy to the touch Example 2 (Aftershave Lotion) 3.7 parts of 95% 5% Shifrose ethanol, 5.5 parts of pure water, 0.5 parts of HCO-40 (manufactured by Nikko Chemicals ■) as a surfactant, 0.3 parts of L-menthol as an aftershave active ingredient, 11480.0 parts of Freon as a propellant, and liquefied 10.0 parts of normal butane with a purity of 95% or more was filled as petroleum gas, and an aerosol valve and button were attached to prepare an aftershave lotion aerosol composition.

The physical properties of the resulting aerosol composition were measured in the same manner as in Example 1, including foam adhesion, foam breaking sound, and drying properties. The results are shown in Table 1.

Example 3 (Repellent) 2.0 parts of 95% undenatured ethanol, 1.5 parts of isopropyl alcohol, 8.5 parts of pure water, PBC as surfactant
-34 (manufactured by Nikko Chemicals ■) 0.5 parts, Lepper DET (manufactured by Yoshitomi Pharmaceuticals ■) as the repellent active ingredient 1.
08B, L/Tsuba-333 (Made by Old M Pharmaceutical 11s) 0.5
and Cynevirin 222 (manufactured by Yoshitomi Pharmaceutical TM) 1.0
A pressure-resistant aerosol container was filled with 11,477.0 parts of chlorofluorocarbons and 128.0 parts of chlorofluorocarbons as propellants, and an aerosol valve and button were attached to prepare a repellent aerosol composition.

The physical properties of the resulting aerosol composition were measured in the same manner as in Example 1, including foam adhesion, foam breaking sound, and drying properties. The results are shown in Table 1.

Example 4 (Antiperspirant) The contents and propellant of the same aerosol antiperspirant as in Example 1 were filled into an aerosol pressure container, and after an aerosol valve was attached, the internal pressure of the product was 5.5°C at 25°C. 0Kg
An antiperspirant aerosol composition was prepared by pressurizing the tube with N2 gas (310.2 g of N2 gas) and attaching a button so that the pressure was 310.2 g.

The physical properties of the resulting aerosol composition were measured in the same manner as in Example 1, including foam adhesion, foam breaking sound, and drying properties. The results are shown in Table 1.

Comparative Example 1 (antiperspirant) 99% geraniol-denatured ethanol 3 used in Example 1
．． Example 1 except that 3.5 parts of pure water was used instead of 5 parts.
An antiperspirant aerosol composition was obtained in exactly the same manner.

The physical properties of the obtained aerosol composition, such as dispersibility, drying properties, and foam breaking sound, were measured in the same manner as in Example 1. The results are shown in Table 1.

Comparative Example 2 (Aftershave lotion) Aftershave lotion was made in the same manner as in Example 2, except that 3.7 parts of pure water was used instead of 3.7 parts of 95% Shiku-O's denatured ethanol used in Example 2. An aerosol composition was obtained.

The physical properties of the obtained aerosol composition, such as dispersibility, drying properties, and foam breaking sound, were made the same as in Example 1.

It was measured using The results are shown in Table 1.

Comparative Example 3 (Repellent) 3.0 parts of pure water was used in place of 2.0 parts of 95% undenatured ethanol and 1.5 parts of isopropyl alcohol used in Example 3.
An aerosol composition for a repellent was obtained in exactly the same manner as in Example 3 except that 5 parts were used.

The physical properties of the obtained aerosol composition, such as dispersibility, drying properties, and foam breaking sound, were measured in the same manner as in Example 1. The results are shown in Table 1.

〔Effect of the invention〕

In the aerosol composition of the present invention, ethanol and/or isopropyl alcohol is used as a solubilizer or dispersant in a uniformly dispersed manner, and is soluble in water-soluble components and water-insoluble organic compounds. , various active ingredients can be uniformly dispersed and used, thus widening the range of formulations, and since ethanol and/or isopropyl alcohol have a defoaming effect, they do not make loud noises when the foam breaks. It has the effect of emitting.

In addition, ethanol and isopropyl alcohol have low boiling points and are easily vaporized, so they dry quickly, do not feel sticky, and do not drip, so they can be used on vertical surfaces of the human body, and you can feel a refreshing sensation when using them. Osaka Eyazol Co., Ltd. Procedural amendment (voluntary) December 4, 1985 1 Case indication 1985 Patent application No. 195099 2 Name of the invention Aerosol composition 3 The person making the amendment Relationship with Patent Applicant 4 Agent 540 5 Subject of Amendment (1) Contents of Amendment in Column 6 “Detailed Description of the Invention” of Specification (1) “Unexamined Japanese Patent Application Publication No. 1973-1960” on page 2, line 8 of the specification 32053J is corrected to "Japanese Unexamined Patent Publication No. 45-32053."

(2) "Development" on page 2, line 14 is amended to read "invention."

(3) "Pressure composition for producing foam" on page 2, lines 15-16 is corrected to "composition for producing pressurized foam."

(4) Correct “problem” on page 3, line 13 to “problem”.

(5) Change “aqueous solution” in line 10 of page 6 to “aqueous solution 100”.
Correct it to ``part''.

(6) On page 7, line 11, "Bactericidal active ingredients" is corrected to "Bactericidal active ingredients, fragrances, and hair tonic active ingredients."

('7) Delete "kerosene" on page 8, line 16.

(8) On page 11, lines 3 to 4 and on page 14, line 8, the words "pressure-resistant container for aerosol" were replaced with "aluminum pressure-resistant container for aerosol (dropping amount: 300
m1) Correct as J.

(9) Same ■, page 1, line 5, page 13, lines 14-15, same 1
On page 4, line 10 and on the first line of page 15, "aerosol composition" is replaced with "aerosol composition (25)".
0g)'J.

(g)) "Filling" on page 13, lines 12-13 was changed to "aluminum pressure-resistant container for aerosol (dropping amount: 300 m1)".
) and correct it.

01) Same page 13 lines 16-17, same page 14 lines 11-12
In both rows and lines 2 and 3 of page 15, the words "foam adhesion" are replaced with "dispersibility, foam adhesion."
and correct it.

(12) On page 15, lines 4-5, add a new line after “shown in Table 1” and add “Example 5 (body cologne) 3.0 parts of 95% brucine-denatured ethanol, 9.4 parts of pure water, interface 0.4 parts of PBC-44 (manufactured by Nikko Chemicals ■) as an activator, 1.5 parts of isopropyl myristate as an oil component, 0.5 parts of talc as an excipient component, 0.2 parts of CH223 (manufactured by Ohshika Kogyo ■) as a fragrance. An aerosol aluminum pressure-resistant container (dropping amount: 300 ml) was filled with 11,485.0 parts of Freon as a propellant, and an aerosol valve and button were attached to prepare an aerosol composition for body cologne (250 g).

The physical properties of the obtained aerosol composition, such as dispersibility, foam adhesion, foam breaking sound, and drying properties, were measured in the same manner as in Example 1.

The results are shown in Table 1.

Example 6 (anti-itch) 2.0 parts of 95% geraniol-modified ethyl alcohol, 11.3 parts of pure water, 5 parts of PBC-440 as a surfactant,
0.5 part of methyl salicylate as an anti-itch active ingredient;
0.5 parts of menthol, 0.2 parts of diphenhydramine and 0.5 parts of camphor, 0.5 parts of talc as an excipient and 11484.0 parts of chlorofluorocarbon as a propellant were added to an aluminum pressure-resistant container for azole (dropping fA: 300 m).
1), and an aerosol valve and button were attached to prepare an anti-itch composition (250 g).

The physical properties of the resulting aerosol composition were measured in the same manner as in Example 1, including dispersibility, foam adhesion, foam breakage, and drying properties.

The results are shown in Table 1.

Example 7 (hair growth agent) 3.57 parts of 95% brucine denatured ethanol, 0.5 parts of pantothenyl ethyl alcohol, 11.78 parts of purified water,
PBC-44 (manufactured by Nikko Chemicals) as a surfactant
0.4 part, isobutipyr myristate as oil component 1.0 part, hinokitiol 0.05 part as active ingredient of hair tonic, tocopherol acetate 0.05 part, soluble cystine 0.05 part, Jasperia japonica extract 1.0 part, zorcin
Fill a polycarbonate pressure-resistant container for aerosol (dropping amount: 90 ml) with 1.0 parts of menthol, 0.5 parts of menthol, and 11480.0 parts of Freon as a propellant, and attach an aerosol valve and button to prepare an aerosol composition for hair growth. (90g) was produced.

The physical properties of the resulting aerosol composition were measured in the same manner as in Example 1, including dispersibility, foam adhesion, foam breakage, and drying properties.

The results are shown in Table 1. ” Insert.

■ On page 15, lines 11-12, on page 15, lines 19-20, and on page 16, lines 7-8, "dispersibility, drying properties" are replaced with "dispersibility, foam adhesion, drying properties". ”
and correct it.

04) Table 1 on page 17 is amended as follows.

[Margin below]

6 Correct "stickiness" on page 18, line 14 to "stickiness".

that's all

Claims (1)

[Scope of Claims] 1. 0.01 to 10 parts by weight of surfactant and/or 0.1 to 50 parts by weight of powder per 100 parts by weight of 3 to 60% by weight aqueous solution of ethanol and/or isopropyl alcohol.
An aerosol composition comprising 2 to 30 parts by weight of a stock solution prepared by adding 1 part by weight, 0.1 to 50 parts by weight of an active ingredient, and 70 to 98 parts by weight of a propellant whose main component is dichlorotetrafluoroethane. 2. The aerosol composition according to claim 1, which forms a foam that makes a crackling sound by bursting when sprayed in the form of a foam or mist.