JPS62289515A - Lint fabric having surface coated with drug - Google Patents

Abstract

PURPOSE:To obtain the titled line fabric capable of eluting a drug by humor, exuded and leaked from the affected part of the skin and directly exhibiting the drug effect on the affected part, by dissolving the drug in a viscous aqueous solution containing a triglucopolysaccharide, etc., and coating the surface of a lint fabric with the coating drug. CONSTITUTION:A drug, e.g. iodoform, hexachlorophene, benzalkonium chloride, etc., is blended and dissolved in a viscous aqueous solution containing a triglucopolysaccharide and a soluble thickening agent, e.g. polyvinylpyrrolidone, PVA, etc., to prepare a coating drug and coating the surface of a lint fabric selected from gauze, cotton cloth, nonwoven fabric, collagen fiber cloth or fabric prepared by vacuum deposition of aluminum thereon by a gravure printing, casting, roll coating method, etc., without permeating into the whole fabric.

Description

[Detailed Description of the Invention] (a) Industrial Applications This invention 8 belongs to the pharmaceutical industry. - In medical practice, against skin wounds - Inflammation - Sterilization? Poison medicine ~ Used as an anti-inflammatory medicine Is it not used as an analgesic for insect bites, etc.? L, Is it possible to add 7k to a drug that is intended to be used as a bactericidal agent for raw diseases and as an analgesic for pain? A good fortune-telling (outside of biological matter) Shunya? It is understandable) mix it with ζ ~ apply the aqueous solution to the surface of a lint cloth and dry it ~ the drug from the physical sciences ~ Ihi Gakuji. This relates to a method for producing a drug-coated ink-lint cloth that has been stabilized with a drug coated cloth. “To do so, skin captive CIK
6" leaching ~ the amount of leaked body fluids - there is) ζ
A drug that is characterized by its medicinal effect on the skin and eyebrows as the drug dissolves quickly and forcefully even in a small amount of 7 minutes, such as moistening the drug with saliva. It relates to the production of coated lint fabrics.

(B) Conventional techniques f/Totilinto cloth and C. Medical treatment: Protection of easily damaged wounds ~ Drugs ~ Power showing the cloth used for holding gifts and fixing patients, etc. The requirements are that it is clean, flexible, durable, breathable, and moisture absorbent.

The range of special features characterized by iodoform ~ Individual composition of the drugs shown in Section 3 ~ Sex 4 ~ Medicinal efficacy ~ = 1 Action number Kotsumu) has already been used as a medicine. can be~
The one that is still in use today has only one force, so it is effective and safe. There are many things that are unknown, not just power, that can be defeated by Shikarame (all combinations of K2 and R are certain).

Currently, it is a combination of lint cloth and medicine (A)
It contains poultices and (B) astringent 7-inch liquid medicines (represented by acrinol case). There is a made-up cotton wall.

The former (A) is an ointment spread on a lint cloth, and by applying it to the skin, the volatile ingredients in the ointment are removed. )Effect ζTherefore, there is one muscle that increases skin strength A and 11))ζ′;! :
In contrast to the present invention, the active ingredient in poultices is not stable over time - it must be stored in an airtight container for 84 hours. 4. Don't fall. Also, once the compress is in a sealed container that has been opened, it cannot be applied or used. The method of use for temples and history is limited to the stability of n-mouth and r-life.

One of the drawbacks of ointments is that the active ingredient, the drug, contained in the ointment is not fully utilized and most of it remains in the ointment.

Similar to poultices, plasters have the same power as plasters.
The conditions for temple cloth coverinto cloth have been thoroughly tested by GA.
There are different points, but there are points.

f & person CB) V-festival ~ drug power <, #B! This is used as a trick to prevent it from flowing down. As an expedient, gauze
A lint cloth made of cotton, etc. is used.

Therefore, I have yet to find anything that coats a lint cloth with a drug, holds the drug in a stable state, and is immediately useful when used.
゜(c) Problems to be solved by the invention Therefore, conventional pharmaceutical products are those coated on lint cloth with drugs that act directly on the affected area of the skin.c';! :
Namu). If you try to create or use a lint cloth coated with a drug that acts directly on the skin, there are the following problems.

(a) The coating must be flexible and flexible to the lint cloth.

('b) Drug power coated with lint cloth < festival release - first come first served? , Mananamu).

(C) The coated drug must remain safe and effective for a long period of time (-%).

(d) When used for FelJ mouth problems (speed and force), the effect is exerted even after the drug has taken effect (e) Lint cloth ζ (It must act as a lint cloth.)

(f) Washing of chemicals applied to the skin is easy.

To solve these points, it is necessary to solve these problems.The medicine and lint cloth used in the treatment of skin ailments have changed since then. I can't find Risa Reiya or the retired Murao G).

(d) Means for solving the problems The present invention has succeeded in solving the problems of these conventional techniques and developing a medical product useful in medical settings.

! ! Focusing on the fact that there is body fluid (zk) that oozes or leaks from inflammation due to skin disease (g'rSζ stiffness and scarring), it is not possible to use these phenomena, which are physiological reactions of the body throughout life, as a countermeasure. I thought it was GA power 1.

Is the next ζ oblate solid and watery right from the wall? I thought that if an oblate was a drug that had medicinal properties, it would be effective by applying it to a wound. However, even if it was possible to do so, I couldn't believe that there was an inventive wall compared to applying Riko medicine directly.

Therefore, if the lint cloth that protects the affected area is coated with something like oblate, it will be able to do two things at the same time: apply medicine to the affected area and protect the affected area.
I thought that if something like that could be made, it would be a good idea to store the '3gBR as a cell phone. Shiriki 1 Shina Kabera ~ Experimental yearly fruit ζ Koyore, = ~ Starch O-lard is Yumushi degree power < 6 Bow ~ 3 single ・ There is a problem ~]: Gitoku power Roe ~ and the power involved was unbearable.

It's more natural than off-lard! It's true that it uses high amylostarch! Thrifty power＼
It is known that this changes over time, and changes in quality in 4 to 5 weeks.There was a problem with stability over time.Is it similar? Coating S' with a polyvinyl alcohol coating (known as a raw material) and a lint cloth with a high viscosity can easily be applied to the affected skin. A small amount of water as fast as 2 tatami mats was enough to get the drug out, and it was very difficult to use alone.

Furthermore, in certain types of ingredients, when mixed with each other, the properties of the drug gradually change.

Bochenol and cresol ζ are unsuitable as ingredients for coating agents.

Through the repetition of these experiments, we solved the problems that needed to be solved and obtained a method for producing a product that is problematic (and sleepable) by putting it into practical use.The coating agent prepared according to the present invention Without being absorbed by the fibers of the lint cloth, the fibers of the lint cloth can be applied to the surface with just one force.The lint cloth that has been coated with alumina for 9 times is also adhered to the surface of the aluminum foil. In order to be coated with ~ 1 g of lint gravity, it is necessary to wear it every month (G) ~ lint cloth ζ
To combine the force of attraction into life and call it a temple, it is a skin pain sound.
ζThe upper surface of the lint cloth to be pasted is good (G attached to the moon).The first force is also the first force of the drug (because the surface of the lint cloth is coated)
2. Even if the amount of leaked body fluid is high, it can produce medicinal effects.

The success of this invention is the discovery of a method for producing a product with optimal rheology. We have selected and verified a drug that can be dissolved in this aqueous solution and be effective in treating skin diseases without losing the vitality of the tongue.

Lint cloth ζ: F, h = A method of coating the surface of the cloth was discovered by soaking the entire cloth with a coating agent prepared by mixing the liquid and the active agent. The invention of a manufacturing method that is characterized by the following characteristics (it solves the problems of conventional technology).

(E) The method of carrying out the invention and the results of the experiments are described below (9! :'
, ``MJ bait 9 + 18 are limited.
Fukini~4g of povidone iodine~10rnl of water? Dissolve the mixed liquid in a half-ton of water with a stir on the evening of the night. This is used as a coating agent.

(C) Place the coated chemicals into the tray.

(d) Prepare a roll of lint with a width of 30 cm (rolled vertically) made of lint cloth (fine-grained to highly brushed).

(e) Make a roller that is slightly narrower than the width of the tray containing the coating agent, and has a 30-p. force 1 more ζ
Prepare the device so that it will be removed.

(The surface of the roller made in fXe order is the same size as above).
The rotation of the roller described above and the manner in which it rotates in reverse
Rub.

(g) Move the lint cloth between the two rollers by feeding the lint cloth one stroke with one force.Thus, the coating agent is thoroughly applied to one side of the lint cloth. ) Coach ink - By drying the lint cloth to which the drug has adhered with P base and air, the coach ink drug is fixed on the lint cloth and coated.

(i) Since the coated lint cloth can be cut freely, it is possible to cut the lint cloth into a size according to the intended use.

Hook = D Morita 2 When using steamed aluminum for lint cloth, water 1004 to 2 ~ Tricurcopolysaccharide (molecular weight 20
0000) in a range of 5 to 10 g. Stir at room temperature to make a viscous aqueous solution.

The power that is F food (Armica 9
The special surface strength of the well-known lint cloth <+;a! It can be coated without any thick layer, and even in the case of an office building, it can be coated well by adding a thickener.The effect remains the same.

Depending on the application, quick action may be required, or the resultant force may be expected to be slow and effective over a long period of time.These adjustments can be adjusted by the following method.

Appeal the haste + matchmaking (a) Towakurirekopolysaccharide's Nishi-Kai-Ai-hi-hi (7)
(b) Change the molecular weight of triglycopolysaccharide to a substance with a lower molecular weight.

(C) In the gutter tally 1 (shallow the depth of the mesh grooves on the surface of the roller mentioned in order e. ■Create a thick coating). ))Y
, increase the number of Nishi-Kai and Hi in JD9 (7k
(1) Change the molecular weight of the liquid polysaccharide to one with a higher molecular weight.

(C) P-V-P, -P-■-A-2pm-possible? Yong・
It is said that the power of a hundred people is used to prepare the earth's natural power.

(d) Preparation of feeding tally 1 (to remove the poisonous texture of the mesh on the surface of the roller mentioned in order e). Create a good coating according to the method of feeding tally 1 below. You can.

Actual box array-1 Sterilization of the drug coach ink'lint cloth created by removing the method of Power Shrine Tally 1? The following experiment was conducted to confirm the effect of portraiture. A method for confirming the medicinal efficacy of the drug coach interlint fabric produced by the method of the present invention! Ma~
The medicinal efficacy varies depending on the medicinal effect and can only be confirmed by a single experiment (there are many different methods).
There are some cases where the effectiveness and side effects are difficult to ascertain depending on the doctor. Therefore, the method for confirming the medicinal efficacy of the drug-coated lint cloth produced according to the present invention
-3 It is not specified.

First, prepare an agar medium in a Petri dish ~ using a known method (cup? leave) from Riko♀ ■ Bacteria Q oyster WiEB ~ inhibitory effect on the growth of Staphylococcus aureus ~ Povidone-iodine, whose pharmacological action is already known. A comparison was made using a 10% aqueous solution as a control drug. According to Yoshika Minori, the effect of inhibiting the growth of Itoda seedlings of the drug-coated pallint cloth produced by the method of Ichirikimen Tarry 1 was equivalent to that of the control drug. This indicates that the drug-coated lint cloth fabric produced by the method of the present invention is effective.

(f) Structure of the invention The elements constituting the present invention are as follows.

(a) Selection of lint cloth A lint cloth used for medical purposes has a wide variety of forces. is limited. Also, I was able to confirm for the first time by experimenting that even cloth or non-woven fabrics should not have coarse mesh, and that the optimum thickness for each mesh is 1 mm to 1-5 mm.

('b) Adjustment of coating agent *There are many substances with rheology such as 3, 3, and 4 (from which a liquid can be formed and a coating can be formed on the surface of the cloth ~ the coating agent dries and hardens). It is easy to reversibly use a small amount of water in the mold 1. After discovering a suitable material and repeating the experiment several times, the most suitable coating agent is prepared. This resulted in the creation of an effect similar to that of a liquid, even though the finished blade was solid.

Its first surface is the coating drug (75g ~ triglycopolysaccharide (dedot amount 200,000) 25
g, povidone iodine 4g) book! It was mixed in the I-mixture. (-e) The coating agent, which was an apparent failure, was removed from 75 g of sterilized purified water to 25 g of triglycopolysaccharide (molecular weight 200,000).

It was mixed with 20 ml of cresol soap solution, and a coagulum appeared in the liquid.

(C) Screening of active ingredients Because it requires a special treatment such as coating the surface of a lint cloth, it is used for the treatment of skin disorders and has a 954% effect on the pancreatic gland force. I can make a furnace c/)
. i2r] Add MG for 7 minutes to 100% - Items that do not decompose by heat - Items that do not undergo photolysis - Items that do not cause self-synthesis - Items that are stable at around pH neutral *
Disperse the liquid in a raw aqueous solution to make it effective and do not damage the raw material.
These are the things I got from screening things. , the experiment ζ has been carried out with a lot of power (including a lot of things).

(d) Coating method applying Gitano Ep delivery.

As for the technique of coating cloth, I can easily imagine the waterproofing power (Next), and when I imagine the Tourinto patterned Tsukiwa Toya. M) Even if the shift is ζ, these techniques fzr-? ζ, once you apply a can of coating, will you be able to do it? 8 out ~ Peeling ~ Monthly repair G''%1
G- in hopes of success.

According to the present invention C, when the coating agent that has been applied once is needed, the surface force of the lint cloth can be removed by 1 to 2 volumes and distributed.

This request? Oka Tashita's power <(he)'s ('btonζThis is the preparation of the coaching agent shown~rirabia ET]
By adjusting the coating agent to the same degree as the ink used, a thickness of 20 mm can be applied to the cloth surface.
It was invented that it is possible to reduce the coach ink of p~30=- by J%.

(e) Confirmation of 1,000 hits in experimental example - 1. Front opening showing ink. The drug once coated on a lint cloth by the method of the present invention will dissolve in the presence of a small amount of moisture. ? We have been able to confirm through experiments that the drug's effectiveness is reliably demonstrated.

(f) Confirmation of stability and rawness The drug-coated lint cloth produced according to the present invention was left at room temperature for 6 months. In addition to confirming the effectiveness using the nJ-1 method, we also used a liquid chromatograph to confirm changes over time. .

(g) The multi-layered cloth was manufactured according to the present invention and the drug-coated lint cloth was closed for 12 hours. On the other hand, when I tested it, it was decided that positive was half-life, and things that seemed to be positive and negative were found to be negative.

Effects of the invention The present invention ζ ~ Leakage from skin lesions 1 ~ Leakage of living body fluids C: Focusing on ~ Utilizing the body fluids as hydraulic power ~ Exercising effects that are originally only available in liquids The most significant feature is that G) the drug was successfully used in the four major deafnesses.

That Itoyoshi fruit ~ Until now, I've been thinking about the power that has been used in the medical field <Is it the effect that will be released in May? In the future, more and more people will be saved and cured of skin diseases.

(1) The inconvenience of handling liquid drugs has been solved.

(2) Solved the inconvenience of weighing liquid drugs.

(3) It is possible to mass produce the wall, and it is easy to leave it alone.

(4) Solve the problem of self-instability of the liquid drug and make it stable over time.

(5) Medical elegance ~ Medication and treatment can be done at the same time ~
fX Hi rate Ihika (I can figure it out.

(6) It is very suitable as a dosage form for emergency drugs.

(7) There are fewer people who seek the same effect by applying it to Tobien's Neri ointment.

[Brief explanation of the drawing]

Figure 1 C is a schematic diagram of the manufacturing process of the present invention. Second figure? , Well, Coach Ink - The third perspective view of the roller for applying the drug to the lint cloth! Yoichi Exhibition of drug-coated lint fabric of the present invention 5
43fi clear drawing (aluminum vapor deposited lint cloth) 4th drawing - 3 minutes enlarged cross section of the 3rd drawing 8? Figure 5 Figure ζ Figure 1 Three parts of the drug-coated lint cloth of the present invention One figure Roll of lint cloth 2 Tray 3 Coating agent 4 Sealer with rubber surface 5 Roller with 24 Btu mesh Roller 6 Roller 7 Roller 8 Drying box 9 Lint cloth winding roller a Lint cloth b Aluminum foil C Coating agent

Claims (8)

[Claims] (1) When a drug is coated on the surface of a lint cloth and applied, body fluids seeping or leaking from the affected area of the skin can cause
A method for manufacturing drug-coated lint cloth, which is characterized by the elution of the coated drug and its medicinal effect directly on the affected skin area. (2) The method according to claim 1, wherein the lint cloth is gauze, cotton cloth, nonwoven fabric, collagen fiber cloth, or aluminum vapor-deposited thereon. (3) The drugs are iodoform, povidone-iodine, hexachlorophene, acrinol, benzethrium chloride, benzalkonium chloride, chlorhexidine gluconate, polyvinylpyrrolidone, vinyl acetate, alkylpolyaminoethylglycine hydrochloride, clotrimazole, miconazole nitrate, econazole nitrate, Domiphene bromide, indomethacin, ketobrofen, flurbibrofen, diclofenac, fradiomycin, procaine hydrochloride, lidocaine,
The claimed drug is a drug prepared with one or more drugs from ethyl aminobenzoate, dexamethasone, adrenochrome, dibucaine hydrochloride, polyvinyl alcohol, insulin, cyclodextrin, prostaglandin, delicanium chloride, and triglucopolysaccharide. The method described in Scope 1. (4) The method according to claim 1, wherein the drug-coated lint cloth can be cut into any size and can be used in combination with adhesive tape, etc. (5) Medicinal effects include local antipruritic, analgesic, anti-inflammatory, and sterilizing effects on the affected skin area.
The method according to claim 1, which is intended for disinfection. (6) The method according to claim 1, wherein the coating technology is an application of printing technology such as a gravure printing method, or a basic technology such as a casting method or a roll coater method, or an application thereof. (7) The method according to claim 1, wherein the drug-coated lint cloth is within the range that requires manufacturing permission and approval as a medical drug or over-the-counter drug as stipulated by the Pharmaceutical Affairs Law. (8) The method according to claims 1 and 2, wherein the lint cloth has a soft touch and is excellent in skin protection, and has hygroscopicity and cleanliness.