JPS6224073B2 - - Google Patents

Info

Publication number: JPS6224073B2
Authority: JP; Japan
Prior art keywords: lysine; inhibitors; resistant; ferm; ability
Prior art date: 1979-08-28
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.): Expired

Application number

JP10945979A

Other languages

English (en)

Japanese (ja)

Other versions

JPS5632995A (en

Inventor

Minoru Yoshimura

Sumio Inoe

Shigeo Ikeda

Hiroi Yoshii

Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)

Ajinomoto Co Inc

Original Assignee

Ajinomoto Co Inc

Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)

1979-08-28

Filing date

1979-08-28

Publication date

1987-05-26

1979-08-28 Application filed by Ajinomoto Co Inc filed Critical Ajinomoto Co Inc

1979-08-28 Priority to JP10945979A priority Critical patent/JPS5632995A/ja

1981-04-02 Publication of JPS5632995A publication Critical patent/JPS5632995A/ja

1987-05-26 Publication of JPS6224073B2 publication Critical patent/JPS6224073B2/ja

Status Granted legal-status Critical Current

Links

239000003112 inhibitor Substances 0.000 claims description 33
KDXKERNSBIXSRK-YFKPBYRVSA-N L-lysine Chemical compound NCCCC[C@H](N)C(O)=O KDXKERNSBIXSRK-YFKPBYRVSA-N 0.000 claims description 32
230000026731 phosphorylation Effects 0.000 claims description 18
238000006366 phosphorylation reaction Methods 0.000 claims description 18
239000004472 Lysine Substances 0.000 claims description 17
235000019766 L-Lysine Nutrition 0.000 claims description 15
ZRALSGWEFCBTJO-UHFFFAOYSA-N Guanidine Chemical compound NC(N)=N ZRALSGWEFCBTJO-UHFFFAOYSA-N 0.000 claims description 12
230000000241 respiratory effect Effects 0.000 claims description 12
238000000034 method Methods 0.000 claims description 9
241000186146 Brevibacterium Species 0.000 claims description 7
WTDHULULXKLSOZ-UHFFFAOYSA-N Hydroxylamine hydrochloride Chemical compound Cl.ON WTDHULULXKLSOZ-UHFFFAOYSA-N 0.000 claims description 7
PTLRDCMBXHILCL-UHFFFAOYSA-M sodium arsenite Chemical compound [Na+].[O-][As]=O PTLRDCMBXHILCL-UHFFFAOYSA-M 0.000 claims description 7
241000186216 Corynebacterium Species 0.000 claims description 6
CHJJGSNFBQVOTG-UHFFFAOYSA-N N-methyl-guanidine Natural products CNC(N)=N CHJJGSNFBQVOTG-UHFFFAOYSA-N 0.000 claims description 6
SWSQBOPZIKWTGO-UHFFFAOYSA-N dimethylaminoamidine Natural products CN(C)C(N)=N SWSQBOPZIKWTGO-UHFFFAOYSA-N 0.000 claims description 6
238000004519 manufacturing process Methods 0.000 claims description 6
238000000855 fermentation Methods 0.000 claims description 3
230000004151 fermentation Effects 0.000 claims description 3
238000012258 culturing Methods 0.000 claims description 2
WPLOVIFNBMNBPD-ATHMIXSHSA-N subtilin Chemical compound CC1SCC(NC2=O)C(=O)NC(CC(N)=O)C(=O)NC(C(=O)NC(CCCCN)C(=O)NC(C(C)CC)C(=O)NC(=C)C(=O)NC(CCCCN)C(O)=O)CSC(C)C2NC(=O)C(CC(C)C)NC(=O)C1NC(=O)C(CCC(N)=O)NC(=O)C(CC(C)C)NC(=O)C(NC(=O)C1NC(=O)C(=C/C)/NC(=O)C(CCC(N)=O)NC(=O)C(CC(C)C)NC(=O)C(C)NC(=O)CNC(=O)C(NC(=O)C(NC(=O)C2NC(=O)CNC(=O)C3CCCN3C(=O)C(NC(=O)C3NC(=O)C(CC(C)C)NC(=O)C(=C)NC(=O)C(CCC(O)=O)NC(=O)C(NC(=O)C(CCCCN)NC(=O)C(N)CC=4C5=CC=CC=C5NC=4)CSC3)C(C)SC2)C(C)C)C(C)SC1)CC1=CC=CC=C1 WPLOVIFNBMNBPD-ATHMIXSHSA-N 0.000 claims description 2
229960003646 lysine Drugs 0.000 description 14
238000006243 chemical reaction Methods 0.000 description 9
UKAUYVFTDYCKQA-UHFFFAOYSA-N -2-Amino-4-hydroxybutanoic acid Natural products OC(=O)C(N)CCO UKAUYVFTDYCKQA-UHFFFAOYSA-N 0.000 description 6
IJGRMHOSHXDMSA-UHFFFAOYSA-N Atomic nitrogen Chemical compound N#N IJGRMHOSHXDMSA-UHFFFAOYSA-N 0.000 description 6
WQZGKKKJIJFFOK-GASJEMHNSA-N Glucose Natural products OC[C@H]1OC(O)[C@H](O)[C@@H](O)[C@@H]1O WQZGKKKJIJFFOK-GASJEMHNSA-N 0.000 description 6
XSQUKJJJFZCRTK-UHFFFAOYSA-N Urea Chemical compound NC(N)=O XSQUKJJJFZCRTK-UHFFFAOYSA-N 0.000 description 6
239000008103 glucose Substances 0.000 description 6
244000005700 microbiome Species 0.000 description 6
230000001580 bacterial effect Effects 0.000 description 5
230000000694 effects Effects 0.000 description 5
241000894006 Bacteria Species 0.000 description 4
VTYYLEPIZMXCLO-UHFFFAOYSA-L Calcium carbonate Chemical compound [Ca+2].[O-]C([O-])=O VTYYLEPIZMXCLO-UHFFFAOYSA-L 0.000 description 4
229940079593 drug Drugs 0.000 description 4
239000003814 drug Substances 0.000 description 4
229930027945 nicotinamide-adenine dinucleotide Natural products 0.000 description 4
BOPGDPNILDQYTO-NNYOXOHSSA-N nicotinamide-adenine dinucleotide Chemical compound C1=CCC(C(=O)N)=CN1[C@H]1[C@H](O)[C@H](O)[C@@H](COP(O)(=O)OP(O)(=O)OC[C@@H]2[C@H]([C@@H](O)[C@@H](O2)N2C3=NC=NC(N)=C3N=C2)O)O1 BOPGDPNILDQYTO-NNYOXOHSSA-N 0.000 description 4
230000003647 oxidation Effects 0.000 description 4
238000007254 oxidation reaction Methods 0.000 description 4
239000008363 phosphate buffer Substances 0.000 description 4
230000029058 respiratory gaseous exchange Effects 0.000 description 4
QTBSBXVTEAMEQO-UHFFFAOYSA-N Acetic acid Chemical compound CC(O)=O QTBSBXVTEAMEQO-UHFFFAOYSA-N 0.000 description 3
QGZKDVFQNNGYKY-UHFFFAOYSA-N Ammonia Chemical compound N QGZKDVFQNNGYKY-UHFFFAOYSA-N 0.000 description 3
LFQSCWFLJHTTHZ-UHFFFAOYSA-N Ethanol Chemical compound CCO LFQSCWFLJHTTHZ-UHFFFAOYSA-N 0.000 description 3
QVGXLLKOCUKJST-UHFFFAOYSA-N atomic oxygen Chemical compound [O] QVGXLLKOCUKJST-UHFFFAOYSA-N 0.000 description 3
239000004202 carbamide Substances 0.000 description 3
229910052757 nitrogen Inorganic materials 0.000 description 3
239000001301 oxygen Substances 0.000 description 3
229910052760 oxygen Inorganic materials 0.000 description 3
239000004061 uncoupling agent Substances 0.000 description 3
XLYOFNOQVPJJNP-UHFFFAOYSA-N water Chemical compound O XLYOFNOQVPJJNP-UHFFFAOYSA-N 0.000 description 3
YBJHBAHKTGYVGT-ZKWXMUAHSA-N (+)-Biotin Chemical compound N1C(=O)N[C@@H]2[C@H](CCCCC(=O)O)SC[C@@H]21 YBJHBAHKTGYVGT-ZKWXMUAHSA-N 0.000 description 2
229920001817 Agar Polymers 0.000 description 2
OKTJSMMVPCPJKN-UHFFFAOYSA-N Carbon Chemical compound [C] OKTJSMMVPCPJKN-UHFFFAOYSA-N 0.000 description 2
UKAUYVFTDYCKQA-VKHMYHEASA-N L-homoserine Chemical compound OC(=O)[C@@H](N)CCO UKAUYVFTDYCKQA-VKHMYHEASA-N 0.000 description 2
KDXKERNSBIXSRK-UHFFFAOYSA-N Lysine Natural products NCCCCC(N)C(O)=O KDXKERNSBIXSRK-UHFFFAOYSA-N 0.000 description 2
OFOBLEOULBTSOW-UHFFFAOYSA-N Malonic acid Chemical compound OC(=O)CC(O)=O OFOBLEOULBTSOW-UHFFFAOYSA-N 0.000 description 2
PXIPVTKHYLBLMZ-UHFFFAOYSA-N Sodium azide Chemical compound [Na+].[N-]=[N+]=[N-] PXIPVTKHYLBLMZ-UHFFFAOYSA-N 0.000 description 2
108010073771 Soybean Proteins Proteins 0.000 description 2
241000319304 [Brevibacterium] flavum Species 0.000 description 2
239000008272 agar Substances 0.000 description 2
238000004458 analytical method Methods 0.000 description 2
229910000019 calcium carbonate Inorganic materials 0.000 description 2
229910052799 carbon Inorganic materials 0.000 description 2
238000005119 centrifugation Methods 0.000 description 2
XBDQKXXYIPTUBI-UHFFFAOYSA-N dimethylselenoniopropionate Natural products CCC(O)=O XBDQKXXYIPTUBI-UHFFFAOYSA-N 0.000 description 2
235000018977 lysine Nutrition 0.000 description 2
150000007524 organic acids Chemical class 0.000 description 2
235000005985 organic acids Nutrition 0.000 description 2
BASFCYQUMIYNBI-UHFFFAOYSA-N platinum Chemical compound [Pt] BASFCYQUMIYNBI-UHFFFAOYSA-N 0.000 description 2
NNFCIKHAZHQZJG-UHFFFAOYSA-N potassium cyanide Chemical compound [K+].N#[C-] NNFCIKHAZHQZJG-UHFFFAOYSA-N 0.000 description 2
239000002683 reaction inhibitor Substances 0.000 description 2
230000000284 resting effect Effects 0.000 description 2
GHSJKUNUIHUPDF-UHFFFAOYSA-N s-(2-aminoethyl)-l-cysteine Chemical compound NCCSCC(N)C(O)=O GHSJKUNUIHUPDF-UHFFFAOYSA-N 0.000 description 2
150000003839 salts Chemical class 0.000 description 2
230000001954 sterilising effect Effects 0.000 description 2
239000000126 substance Substances 0.000 description 2
DLYUQMMRRRQYAE-UHFFFAOYSA-N tetraphosphorus decaoxide Chemical compound O1P(O2)(=O)OP3(=O)OP1(=O)OP2(=O)O3 DLYUQMMRRRQYAE-UHFFFAOYSA-N 0.000 description 2
DPJRMOMPQZCRJU-UHFFFAOYSA-M thiamine hydrochloride Chemical compound Cl.[Cl-].CC1=C(CCO)SC=[N+]1CC1=CN=C(C)N=C1N DPJRMOMPQZCRJU-UHFFFAOYSA-M 0.000 description 2
229960000344 thiamine hydrochloride Drugs 0.000 description 2
235000019190 thiamine hydrochloride Nutrition 0.000 description 2
239000011747 thiamine hydrochloride Substances 0.000 description 2
NWUYHJFMYQTDRP-UHFFFAOYSA-N 1,2-bis(ethenyl)benzene;1-ethenyl-2-ethylbenzene;styrene Chemical compound C=CC1=CC=CC=C1.CCC1=CC=CC=C1C=C.C=CC1=CC=CC=C1C=C NWUYHJFMYQTDRP-UHFFFAOYSA-N 0.000 description 1
UFBJCMHMOXMLKC-UHFFFAOYSA-N 2,4-dinitrophenol Chemical compound OC1=CC=C([N+]([O-])=O)C=C1[N+]([O-])=O UFBJCMHMOXMLKC-UHFFFAOYSA-N 0.000 description 1
125000000022 2-aminoethyl group Chemical group [H]C([*])([H])C([H])([H])N([H])[H] 0.000 description 1
ZVGCIMVMXFUSDB-UHFFFAOYSA-N 2-methyl-1-nitro-1-nitrosoguanidine Chemical compound CN=C(N)N(N=O)[N+]([O-])=O ZVGCIMVMXFUSDB-UHFFFAOYSA-N 0.000 description 1
NDXGCVGKTPQXFA-UHFFFAOYSA-N 3-chloroazepan-2-one Chemical compound ClC1CCCCNC1=O NDXGCVGKTPQXFA-UHFFFAOYSA-N 0.000 description 1
VHUUQVKOLVNVRT-UHFFFAOYSA-N Ammonium hydroxide Chemical compound [NH4+].[OH-] VHUUQVKOLVNVRT-UHFFFAOYSA-N 0.000 description 1
241000186226 Corynebacterium glutamicum Species 0.000 description 1
108090000790 Enzymes Proteins 0.000 description 1
102000004190 Enzymes Human genes 0.000 description 1
QNAYBMKLOCPYGJ-REOHCLBHSA-N L-alanine Chemical compound C[C@H](N)C(O)=O QNAYBMKLOCPYGJ-REOHCLBHSA-N 0.000 description 1
BVHLGVCQOALMSV-JEDNCBNOSA-N L-lysine hydrochloride Chemical compound Cl.NCCCC[C@H](N)C(O)=O BVHLGVCQOALMSV-JEDNCBNOSA-N 0.000 description 1
239000001888 Peptone Substances 0.000 description 1
108010080698 Peptones Proteins 0.000 description 1
FAPWRFPIFSIZLT-UHFFFAOYSA-M Sodium chloride Chemical compound [Na+].[Cl-] FAPWRFPIFSIZLT-UHFFFAOYSA-M 0.000 description 1
229920002472 Starch Polymers 0.000 description 1
CZMRCDWAGMRECN-UGDNZRGBSA-N Sucrose Chemical compound O[C@H]1[C@H](O)[C@@H](CO)O[C@@]1(CO)O[C@@H]1[C@H](O)[C@@H](O)[C@H](O)[C@@H](CO)O1 CZMRCDWAGMRECN-UGDNZRGBSA-N 0.000 description 1
229930006000 Sucrose Natural products 0.000 description 1
239000002253 acid Substances 0.000 description 1
235000004279 alanine Nutrition 0.000 description 1
150000001298 alcohols Chemical class 0.000 description 1
150000003863 ammonium salts Chemical class 0.000 description 1
BFNBIHQBYMNNAN-UHFFFAOYSA-N ammonium sulfate Chemical compound N.N.OS(O)(=O)=O BFNBIHQBYMNNAN-UHFFFAOYSA-N 0.000 description 1
229910052921 ammonium sulfate Inorganic materials 0.000 description 1
235000011130 ammonium sulphate Nutrition 0.000 description 1
229910052785 arsenic Inorganic materials 0.000 description 1
RQNWIZPPADIBDY-UHFFFAOYSA-N arsenic atom Chemical compound [As] RQNWIZPPADIBDY-UHFFFAOYSA-N 0.000 description 1
AQLMHYSWFMLWBS-UHFFFAOYSA-N arsenite(1-) Chemical compound O[As](O)[O-] AQLMHYSWFMLWBS-UHFFFAOYSA-N 0.000 description 1
WQZGKKKJIJFFOK-VFUOTHLCSA-N beta-D-glucose Chemical compound OC[C@H]1O[C@@H](O)[C@H](O)[C@@H](O)[C@@H]1O WQZGKKKJIJFFOK-VFUOTHLCSA-N 0.000 description 1
229960002685 biotin Drugs 0.000 description 1
235000020958 biotin Nutrition 0.000 description 1
239000011616 biotin Substances 0.000 description 1
238000009835 boiling Methods 0.000 description 1
229940041514 candida albicans extract Drugs 0.000 description 1
239000006285 cell suspension Substances 0.000 description 1
238000004737 colorimetric analysis Methods 0.000 description 1
239000012141 concentrate Substances 0.000 description 1
230000021615 conjugation Effects 0.000 description 1
238000007796 conventional method Methods 0.000 description 1
238000001816 cooling Methods 0.000 description 1
229910052802 copper Inorganic materials 0.000 description 1
239000010949 copper Substances 0.000 description 1
238000002425 crystallisation Methods 0.000 description 1
230000008025 crystallization Effects 0.000 description 1
230000003247 decreasing effect Effects 0.000 description 1
239000000284 extract Substances 0.000 description 1
230000002349 favourable effect Effects 0.000 description 1
230000009036 growth inhibition Effects 0.000 description 1
150000002357 guanidines Chemical class 0.000 description 1
238000010438 heat treatment Methods 0.000 description 1
230000001939 inductive effect Effects 0.000 description 1
230000002401 inhibitory effect Effects 0.000 description 1
239000003456 ion exchange resin Substances 0.000 description 1
229920003303 ion-exchange polymer Polymers 0.000 description 1
239000007788 liquid Substances 0.000 description 1
239000013028 medium composition Substances 0.000 description 1
150000007522 mineralic acids Chemical class 0.000 description 1
239000000203 mixture Substances 0.000 description 1
235000013379 molasses Nutrition 0.000 description 1
239000003471 mutagenic agent Substances 0.000 description 1
231100000707 mutagenic chemical Toxicity 0.000 description 1
230000003505 mutagenic effect Effects 0.000 description 1
230000035772 mutation Effects 0.000 description 1
FEMOMIGRRWSMCU-UHFFFAOYSA-N ninhydrin Chemical compound C1=CC=C2C(=O)C(O)(O)C(=O)C2=C1 FEMOMIGRRWSMCU-UHFFFAOYSA-N 0.000 description 1
235000015097 nutrients Nutrition 0.000 description 1
235000016709 nutrition Nutrition 0.000 description 1
230000036961 partial effect Effects 0.000 description 1
235000019319 peptone Nutrition 0.000 description 1
229910052697 platinum Inorganic materials 0.000 description 1
BDERNNFJNOPAEC-UHFFFAOYSA-N propan-1-ol Chemical compound CCCO BDERNNFJNOPAEC-UHFFFAOYSA-N 0.000 description 1
235000019260 propionic acid Nutrition 0.000 description 1
230000007065 protein hydrolysis Effects 0.000 description 1
IUVKMZGDUIUOCP-BTNSXGMBSA-N quinbolone Chemical compound O([C@H]1CC[C@H]2[C@H]3[C@@H]([C@]4(C=CC(=O)C=C4CC3)C)CC[C@@]21C)C1=CCCC1 IUVKMZGDUIUOCP-BTNSXGMBSA-N 0.000 description 1
230000005855 radiation Effects 0.000 description 1
230000002829 reductive effect Effects 0.000 description 1
210000002345 respiratory system Anatomy 0.000 description 1
239000011780 sodium chloride Substances 0.000 description 1
229940001941 soy protein Drugs 0.000 description 1
235000019710 soybean protein Nutrition 0.000 description 1
239000008107 starch Substances 0.000 description 1
235000019698 starch Nutrition 0.000 description 1
-1 starch hydrolyzate Chemical class 0.000 description 1
239000008223 sterile water Substances 0.000 description 1
238000004659 sterilization and disinfection Methods 0.000 description 1
238000003756 stirring Methods 0.000 description 1
239000005720 sucrose Substances 0.000 description 1
235000000346 sugar Nutrition 0.000 description 1
150000008163 sugars Chemical class 0.000 description 1
239000006228 supernatant Substances 0.000 description 1
WWJZWCUNLNYYAU-UHFFFAOYSA-N temephos Chemical compound C1=CC(OP(=S)(OC)OC)=CC=C1SC1=CC=C(OP(=S)(OC)OC)C=C1 WWJZWCUNLNYYAU-UHFFFAOYSA-N 0.000 description 1
238000006276 transfer reaction Methods 0.000 description 1
239000012138 yeast extract Substances 0.000 description 1

Landscapes

Preparation Of Compounds By Using Micro-Organisms (AREA)

JP10945979A 1979-08-28 1979-08-28 Preparation of l-lysine by fermentation Granted JPS5632995A (en)

Priority Applications (1)

Application Number	Priority Date	Filing Date	Title
JP10945979A JPS5632995A (en)	1979-08-28	1979-08-28	Preparation of l-lysine by fermentation

Applications Claiming Priority (1)

Application Number	Priority Date	Filing Date	Title
JP10945979A JPS5632995A (en)	1979-08-28	1979-08-28	Preparation of l-lysine by fermentation

Publications (2)

Publication Number	Publication Date
JPS5632995A JPS5632995A (en)	1981-04-02
JPS6224073B2 true JPS6224073B2 (es)	1987-05-26

Family

ID=14510763

Family Applications (1)

Application Number	Title	Priority Date	Filing Date
JP10945979A Granted JPS5632995A (en)	1979-08-28	1979-08-28	Preparation of l-lysine by fermentation

Country Status (1)

Country	Link
JP (1)	JPS5632995A (es)

Families Citing this family (12)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
US4766469A (en) *	1986-01-06	1988-08-23	Siliconix Incorporated	Integrated buried zener diode and temperature compensation transistor
CA2583514C (en)	2004-10-07	2013-07-02	Ajinomoto Co., Inc.	Method for producing basic substance
JP2010041920A (ja)	2006-12-19	2010-02-25	Ajinomoto Co Inc	Ｌ−アミノ酸の製造法
JP2011067095A (ja)	2008-01-10	2011-04-07	Ajinomoto Co Inc	発酵法による目的物質の製造法
EP2248906A4 (en)	2008-01-23	2012-07-11	Ajinomoto Kk	PROCESS FOR THE PREPARATION OF L-AMINO ACID
WO2011013707A1 (ja)	2009-07-29	2011-02-03	味の素株式会社	Ｌ-アミノ酸の製造法
JP2012223091A (ja)	2009-08-25	2012-11-15	Ajinomoto Co Inc	Ｌ−アミノ酸の製造法
BR112013027845A2 (pt)	2011-05-18	2017-01-03	Ajinomoto Kk	Imunoestimulante, ração, método para produzir um imunoestimulante, e, método para imunoestimulação
MY185322A (en)	2013-05-13	2021-05-04	Ajinomoto Kk	Method for producing l-amino acid
BR112016008830B1 (pt)	2013-10-23	2023-02-23	Ajinomoto Co., Inc	Método para produzir uma substância alvo
JP7066977B2 (ja)	2017-04-03	2022-05-16	味の素株式会社	Ｌ－アミノ酸の製造法
EP4505875A1 (en)	2022-04-04	2025-02-12	Ajinomoto Co., Inc.	Method for controlling parasitic plants

1979
- 1979-08-28 JP JP10945979A patent/JPS5632995A/ja active Granted

Also Published As

Publication number	Publication date
JPS5632995A (en)	1981-04-02

Publication	Publication Date	Title
JPS5810075B2 (ja)	1983-02-24	新規変異株
US4347317A (en)	1982-08-31	Method for producing L-glutamic acid by fermentation
JPS58158192A (ja)	1983-09-20	発酵法によるｌ−グルタミン酸の製造方法
JPS6224073B2 (es)	1987-05-26
JPH02186995A (ja)	1990-07-23	発酵法によるｌ‐アルギニンの製造法
JP2876739B2 (ja)	1999-03-31	発酵法によるｌ―リジンの製造法
JP3006929B2 (ja)	2000-02-07	発酵法によるｌ−バリンの製造法
JPS6224074B2 (es)	1987-05-26
JP2578463B2 (ja)	1997-02-05	発酵法によるｌ−リジンの製造法
US4368266A (en)	1983-01-11	Method for producing L-glutamic acid by fermentation
JPH0644871B2 (ja)	1994-06-15	発酵法によるｌ−ロイシンの製造法
JPS61119194A (ja)	1986-06-06	発酵法によるｌ−オルニチンの製造法
JP2943312B2 (ja)	1999-08-30	発酵法によるｌ―リジンの製造法
JP2995816B2 (ja)	1999-12-27	発酵法によるｌ―リジンの製造法
JP2817228B2 (ja)	1998-10-30	Ｌ―グルタミン酸の製造法
JPS5835079B2 (ja)	1983-07-30	Ｌ−イソロイシンの製造法
JP2817189B2 (ja)	1998-10-27	発酵法によるｌ―スレオニンの製造法
JPS6236675B2 (es)	1987-08-07
JPS6236677B2 (es)	1987-08-07
JPH0313874B2 (es)	1991-02-25
JPS6234398B2 (es)	1987-07-27
JPS6234392B2 (es)	1987-07-27
JPS58170488A (ja)	1983-10-07	発酵法によるｌ−アスパラギン酸の製造法
JPH0822235B2 (ja)	1996-03-06	発酵法によるｌ−グルタミン酸の製造法
JPS61128897A (ja)	1986-06-16	発酵法によるｌ−フエニルアラニンの製造法