JPS61272296A - Detergent composition - Google Patents

Abstract

(57) [Summary] This bulletin contains application data before electronic filing, so abstract data is not recorded.

Description

DETAILED DESCRIPTION OF THE INVENTION [Field of Industrial Application] The present invention relates to a cleaning composition. More specifically, the present invention relates to a detergent composition that has a mild effect on the skin and has excellent detergency and foaming power.

Although the detergent composition of the present invention can be used for a wide variety of purposes, it is particularly advantageous when used as a shampoo composition.

[Conventional technology]

Conventionally, cleaning compositions contain anionic surfactants such as alkyl sulfate ester salts and alpha olefin sulfonates, nonionic surfactants such as fatty acid alkylolamides, and amphoteric surfactants such as algyl betaine and alkyl amine oxides. Ionic surfactants have been used.

[Problem that the invention seeks to solve]

When using these surfactants alone, although anionic surfactants have excellent cleaning and foaming power, they are all highly irritating to the skin, and nonionic surfactants are highly irritating to the skin. In the case of surfactants and amphoteric ionic surfactants, they are less irritating to the skin, but their cleaning power and foaming power are insufficient for dirt with heavy oil stains.

The present inventors focused on the above points and, as a result of intensive research, found that surfactants and surfactant compositions with strong protein denaturing power are highly irritating to the skin, while surfactants with low protein denaturing power It has been found that the irritation to the skin is significantly reduced in the surfactant composition.

Furthermore, it has been shown that if a specific anionic surfactant and a specific nonionic surfactant are combined, the protein denaturation rate will be synergistically reduced and skin irritation will be significantly reduced compared to when each agent is used alone. I found it. The present invention is based on this knowledge.

(The following is a blank space) [Means for solving the problem] That is, the present invention has the following general formula (I) and/or (II) or 18
a saturated or unsaturated hydrocarbon group, X and Y each represent hydrogen, an alkali metal, or an organic amine, and j, m, and n each represent a number from 0 to 10. ) and a nonionic surfactant having an HLB of 8 to 16.

(Left below) A particularly preferred blending ratio of the active ingredients is such that the weight ratio of the phosphate ester surfactant represented by general formula (4) or (II) to the nonionic surfactant having an HLB of 10 to 16 is The ratio is in the range of 10:1 to 1:1, and the total of the two accounts for about 10 to 50 parts by weight.

The present inventors have found that when a phosphate ester type surfactant represented by the general formula (I) or (n) and a nonionic surfactant having an HLB of 10 to 16 are mixed at an appropriate mixing ratio, foaming occurs. The surfactant ability such as detergency and detergency is determined by the general formula (A)
At the same time, the protein denaturation power, that is, the skin irritation, is not inferior to that of the anionic surfactant alone, expressed as
It has been discovered that the surfactant is significantly reduced to a degree that is superior to, but not inferior to, the case of using a nonionic surfactant alone.

Considering the phenomenon of this synergistic effect from measurements of critical micelle concentration, etc., it is estimated that this phenomenon is due to the formation of mixed micelles. If the nonionic surfactant used has an HLB of less than 8, the protein denaturation power will decrease, but the HLB
Perhaps because of the low surface active agent, the nonionic surfactant acts like an oil, resulting in significantly inferior foaming and cleaning properties.

Furthermore, when a nonionic surfactant having an HLB of 16 or more is used, the protein denaturation performance is not significantly reduced and the foaming property is also poor. As mentioned above, the HLB of the nonionic surfactant is preferably 10 to 16, but the HLB is preferably 11 to 14, which is particularly effective.

The phosphoric acid ester surfactant used in the present invention preferably has an added mole of ethylene oxide of 0 to 3, and in particular has no ethylene oxide added and has an alkyl group having 12 to 14 carbon atoms. It is preferable to have the following. Preferred examples include sodium heptano or dilauryl phosphate, potassium heptano or dilauryl phosphate, jetanolamine mono- or dilauryl phosphate, triethanolamine mono- or dilauryl phosphate, sodium heptano or similistyl phosphate,
Examples include potassium mono- or dilauryl phosphate, jetanolamine mono- or dilauryl phosphate, triethanolamine mono- or dilauryl phosphate, and the like. When using this phosphate ester surfactant, it is more preferable to mix the compounds represented by the above formula (I) and formula (n) at a weight ratio of 10:0 to 5:5.

The nonionic surfactant used in the present invention is HL
B 10 to 16, preferably 11 to 14 nonionic surfactants, polyoxyethylene alkyl ether type, polyoxyethylene alkyl phenyl ester type, polyoxyethylene polyoxypropylene alkyl ester type, polyoxyethylene polyhydric Examples include alcohol fatty acid ester type, polyglycerin fatty acid ester type, and polyoxyethylated castor oil type.

A particularly preferred nonionic surfactant in the present invention is a polyoxyethylene alkyl ether type.

In addition, HLB is the hydrophilic-lipophilic balance (Hydr
ophilic-Lypophilic Balanc
e), and in the present invention, a value calculated using the formula by Koen and Teramura et al. is used.

In addition to the above-mentioned essential components, the cleaning composition of the present invention can contain components of known cleaning compositions.

For example, amphoteric surfactants, cationic surfactants, higher alcohols, lanolin derivatives, protein derivatives, oily components such as fatty acid esters of polyethylene glycol, propylene glycol, glycerin, polyethylene glycol in amounts that do not impair the effects of the present invention. Moisturizer ingredients such as, plant extracts such as crude drugs, water-soluble polymer substances such as cationic, anionic, and nonionic, sequestrants, preservatives, disinfectants, PH adjusters, ultraviolet absorbers, antioxidants, etc. Agents, dyes, fragrances, etc. can be added as necessary.

(Left below) Cationic polymeric substances that are blended especially in shampoo compositions for the purpose of improving usability, such as cationically modified cellulose ether derivatives (Polymer JR (U, C, C'
), polyvinylpyrrolidone derivative quaternary ammonium (GAF, etc.), diallyldimethylammonium chloride polymer (Merk, etc.), polyacrylic acid derivative quaternary ammonium (Cart, etc.)
EX (NationalStarch, etc.), polyamide derivative quaternary ammonium (5andoz, etc.) increases the amount of adsorption to the hair by blending it into the cleansing composition of the present invention, and has greater usability than when blended with other bases. You can make improvements.

〔Effect of the invention〕

The present invention will be specifically decalcified using experimental examples below.

The test methods considered in the experimental examples are as follows.

Foaming test method CaCO370P In artificial hard water, a sample concentration of 1% solution was
The amount of foaming was measured using a cylindrical cylinder equipped with a stirrer at a temperature of 40°C.

○... Good foaming Foam volume 2000- or more △... Normal foaming Foam volume 1500- or more Less than 2000-×・
・・Poor foaming Foam volume less than 1500 Cleaning test method CaO/MgO=3/1.5'DH A 1% sample concentration solution was prepared with artificial hard water, and artificial sebum-contaminated cloth was washed using wool surge. .

Turbotometer (JISK-3
371) was used to determine the cleaning efficiency from the reflectance before and after cleaning.

RO: Reflectance of raw fabric (wool serge) R3: Reflectance of contaminated cloth RW: Reflectance of contaminated cloth after washing ○... Good cleaning performance Cleaning efficiency 80% or more Δ... Average cleaning performance Cleaning efficiency 60 % or more but less than 80% ×...
Poor cleaning performance Washing efficiency Less than 60% Protein denaturation rate measurement method Using aqueous high performance liquid chromatography, when a sample is added to an egg albumin pH 7 buffer solution at a sample concentration of 1%, the ovalbumin denaturation rate is 220nm
It was measured using the absorption peak.

SaH3: 220 when the sample was added to the ovalbumin buffer
Height of nm absorption peak ■... Ovalbumin denaturation rate less than 30% ○... Ovalbumin denaturation rate 30% or more to less than 60%...
Ovalbumin degeneration rate: 60% or more, less than 80%×...
- Ovalbumin denaturation rate: 80% or more Skin irritation test method Prepare a 10% sample concentration solution with ion-exchanged water, immerse the guinea pig in this test solution for 4 hours every day, and repeat this for 3 days. After 12 hours of immersion, the appearance of a reaction was observed after 2 days. The reaction was evaluated using five criteria: erythema, edema, relaxation, desquamation, and fissures.

◎... is hardly stimulating.

(Erythema appears.) ○... Mild irritation (erythema and relaxation appear.) ×... Severe irritation (erythema, edema, relaxation, and desquamation appear.) ×... Extremely Severe irritation (produced by erythema, edema, relaxation, desquamation, and cracks) Experimental Example 1 A shampoo with the formulation shown in Table 1 below was prepared, and its foaming property, detergency, and protein denaturation rate were prepared.・Skin irritation was investigated.

Experimental Example 2 A shampoo having the formulation shown in Table 2 below was prepared, and its foaming properties, cleaning properties, protein denaturation rate, and skin irritation were examined.

(Margin below) Example 1 A liquid detergent having the following formulation was prepared.

Monolauric acid triethanolamine 20 Polyoxyethylene (EO average 12) 6 Lauryl ether Lauric acid jetanolamide 3 Propylene glycol 5 Ethanol
5 Fragrance 0.3 Water Residual This liquid detergent was subjected to the same performance evaluation test as in Example 1, and the results were as follows: foaming property: ○, detergency: ○, protein denaturation rate: ◎, and guinea pig skin irritation: ◎. . Example 2 A creamy detergent having the following formulation was prepared.

Sodium monolauryl phosphate 20 Sodium monomyristate 10 Polyoxyethylene (EO average 30) 6 Hydrogenated castor oil Polyethylene glycol (molecular weight 1500) 7 Glycerin 15 Sodium chloride 0.5 Fragrance
0.3 Water Residual This creamy detergent was subjected to the same performance evaluation test as in Example 1, and the results were as follows: Foaming Q5 Detergent O1 Protein denaturation rate ◎, Guinea pig skin irritation ◎.

Example 3 A shampoo consisting of the following formulation was prepared.

Monolauryl phosphate 15 Triethanolamine polyoxy (EO average 12) 5 Secondary lauryl ether polyoxyethylene (EO average 3) 5 Lauryl sulfate triethanolamine lauryl dimethylamine oxide 2 Glycerin 3 Cationized cellulose 0.5 (polymer JR-400 (
U, C, C)) Fragrance 0.3 Water Residual This shampoo was subjected to the same performance evaluation test as in Example 1, and the results were as follows: Foaming O1 detergency ○, Protein denaturation rate ◎, Guinea pig skin irritation ◎ was gotten.

Claims (1)

[Claims] The following general formula (I) and/or (II) ▲There are mathematical formulas, chemical formulas, tables, etc.▼...(I) ▲There are mathematical formulas, chemical formulas, tables, etc.▼...(II ) (In the formula, R_1, R_2 and R_3 each represent a saturated hydrocarbon group having 8 to 18 carbon atoms, X and Y each represent hydrogen, an alkali metal or an organic amine, and l, m and n each represent 0 to 18.) 10) and a nonionic surfactant having an HLB of 8 to 16.