JPS61254517A - Skin protecting agent - Google Patents

Abstract

PURPOSE:A skin protecting agent, obtained by incorporating a chitosan salt with other components and having improved protecting effect. CONSTITUTION:A skin protecting agent, obtained by incorporating one or two or more chitosan salts in an amount of 0.1wt% or more, preferably 0.2-30wt% (preferably 4-30wt% when incorporated in a protecting agent in an emulsion system) with other components, and having remarkable skin protecting effect without giving feeling of incompatibility in use. The dosage form is solid, liquid, gel or cream, and a substance modifying the skin protecting agent, e.g. perfume, dyestuff, another drug, humectant or oil, etc., may be used together. The chitosan is obtained by removing calcium carbonate from the shell of a lobster, shrimp or crab, etc., with an acid, deproteinizing the resultant shell with an alkali, and deacetylating the resultant chitin with a more concentrated alkali.

Description

DETAILED DESCRIPTION OF THE INVENTION [Industrial Field of Application] The present invention relates to a skin protective agent that has an excellent protective effect by incorporating chitosan salt.

[Conventional technology] Conventionally, methods of protecting the skin from external effects include skin protection,
This included the use of protective agents or, in the case of the hands, the simpler method of wearing gloves.

Skin protective agents are mainly oily or emulsion-like products that contain oil or powder in addition to oil, and are intended to achieve the effect of a coating with the oil component or a coating with powder particles that are used in combination. That's what I did.

[Problem 3 to be solved by the invention: The hand is the part of the human body that is most exposed to external influences, and the layers that are frequently used in gloves and skin protectants to protect the hands are irritating to the skin. A person who is engaged in work that involves handling chemicals by hand, and in a broader sense, it covers a very wide range of jobs, including housewives who use detergent every day.

An example of a person who is particularly stimulated by chemicals is a perm technician.

When using conventional skin protectants, users of any of these products are concerned about the discomfort caused by the oil, which is an essential effective ingredient, adhering to fingertips, hands, etc., such as stickiness. It has been given a bad reputation as being insignificant.

Although conventional skin protective agents are effective to some extent, they have a disadvantage in that they are not used repeatedly because they do not provide a satisfactory feeling of use, resulting in a vicious cycle in which they are not effective.

Furthermore, the action of putting on gloves has the disadvantage that the delicate sensations in the fingertips are lost due to the gloves, making it impossible to perform detailed work.

[Means for Solving the Problems] In view of the above-mentioned circumstances, the present inventors have conducted intensive research and found that if chitosan salt is added to the skin protective agent, it will not cause any discomfort such as stickiness when used, and will significantly improve the skin's appearance. The inventors discovered that a skin protective agent with a protective effect can be obtained and completed the present invention.

That is, the present invention provides a skin protective agent that does not cause any discomfort during use and has an excellent protective effect, which is characterized by containing chitosan salt.

Chitosan used in the present invention is a substance obtained by deacetylating chitin, which is abundantly contained in the shells of crabs, shrimps, etc., and the exoskeleton of arthropods,
It is D-Glucosamine. Generally, it is obtained by decarboxylating the shells of shrimp, crabs, etc. with acid, deproteinizing with alkali, and deacetylating the resulting chitin with a coarsely concentrated alkali.

Purification treatment may be performed as necessary.

On the other hand, acids that form salts with chitosan include inorganic acids such as hydrochloric acid and nitric acid, simple organic acids such as formic acid, acetic acid, oxalic acid, citric acid, succinic acid, tartaric acid, lactic acid, and adipic acid, and glutamic acid and aspartic acid. These include acidic amino acids, organic acids such as ascorbic acid and pyrrolidone carboxylic acid, and polymers such as polyacrylic acid.

Note that sulfuric acid and phosphoric acid are difficult to use because they do not form salts with chitosan.

Since chitosan has an amino group in its molecule, it forms salts with acids, and these salts are mainly used in the form of aqueous solutions for the skin protection agent according to the present invention.

In addition to a method of separately blending chitosan and an acid to form a chitosan salt in a skin protective agent, a method of preparing the chitosan salt in advance and blending the isolated chitosan salt may be used.

In the present invention, one or more chitosan salts are arbitrarily selected and used, and the amount added to the skin protective agent is 0.1% by weight (hereinafter simply abbreviated as %) as chitosan.

) or more, and if the amount is less than 0.1%, the protective effect is lacking, and if the amount is extremely large, it becomes difficult to dissolve in the skin protective agent.

Preferably, the amount of chitosan is 0.2 to 30%.

In addition, when it is blended into an emulsion-based protective agent, it is preferably 4 to 30%.

Further, the amount of the acid that forms the salt is required to be at least the amount that neutralizes chitosan, and there is no limit to the amount of the acid that can be added in excess as long as it does not deteriorate the quality of the skin protective agent itself.

Any conventional skin protectant can be used as the skin protectant containing chitosan salt. In other words, it can be in solid, liquid, gel, or cream form, and it goes without saying that it can be used in combination with substances that modify the skin protective agent, such as fragrances, pigments, other drugs, moisturizers, and oils. However, care must be taken when adding more moisturizers and oils than necessary, as these may cause an uncomfortable feeling when used.

[Example] <Example 1> Chitosan 10% citric acid
10 P, 0. E, (50) oleyl ether 0.2
Fragrance Appropriate amount Purified water Amount to make the whole amount 100 After dissolving the raw materials below chitosan in purified water, add filtration operation,
A lotion-like skin protectant is obtained.

[Effects of the Invention] The skin protection agent obtained in Example 1 was used as a sample, and was used by 20 technicians engaged in perm treatments at beauty salons for the purpose of protecting their hands from perm treatment solutions.

The method of use was extremely simple: 1 to 2 g of the sample was rubbed into the hands before the perm treatment, and the product was to be used every time the perm treatment was performed on a customer.

The period of use was two weeks, and the average number of uses was 92 times.

In addition, as a control product, the following skin protection agent containing no chitosan salt was simultaneously used on a group of 20 other technicians using a skin care method, and the effects were compared.

Control example> A, Setanol 3 wt% stearic acid 3 Vaseline 8 Glyceryl monostearate 3 Liquid paraffin 20 B, Glycerin 2 Potassium hydroxide 0.3 Purified ice
Quantity C, talc, taking the total as 100
5A oil phase component and B water phase component each at 70%
Dissolve by heating at ℃, add A to B and emulsify. Then C
The powder part is dispersed, processed in an emulsifying machine, and then cooled to obtain a cream-like skin protectant.

The effects of using Example 1 and the control example were evaluated through questionnaires and interviews with the perm technicians who used them.

(The following is a blank space) As is clear from Table 1, many people in the group using the control product answered that it was sticky, had a bad feel on the fingertips, and had no effect, whereas the sample of the present invention The evaluation of the group using the skin protection agent according to the above is surprising.

This is the effect of incorporating chitosan salt into the skin protective agent.

Next, the present invention will be explained in detail with reference to more examples and comparative examples, but the present invention is not limited thereto.

(Left below) Example 2 A, chitosan 0.5% hydrochloric acid
0.5 Carboxyvinyl polymer 0.3 ゛Purified water
Amount B, setanol, taking the total as 100
3 Vaseline 3 Liquid paraffin 3 Glyceryl monostearate I POE (25) Cetyl ether 1 Vitamin E acetate 0.5 Preservative Appropriate amount Fragrance Appropriate amount A water phase component A and B oil phase component are each heated and dissolved at 70°C, Add B to A and emulsify. Thereafter, a cooling treatment is performed to obtain a cream-like skin protectant.

The sample of Example 2 was used by 20 perm technicians, and 18 of them answered that they were satisfied with the usability and effect. Example 3 A6 purified water Amount to make the whole 100 Chitosan 5% lactic acid
3 Succinic acid 3 L-glutamic acid 2 L-ascorbic acid 2 B, titanium dioxide 5 Talc
5. After stirring and dissolving the raw materials for the aqueous phase part of A, the raw materials for the powder part of B are dispersed to obtain a powdered skin protective agent.

The sample of Example 3 was used by 30 housewives.27
The respondents answered that they were satisfied with the usability and effectiveness.

Example 4 Chitosan 30% hydrochloric acid
2 Lactic acid 20 Citric acid 8 Carboxyvinyl polymer 0.3 Acetic acid
0.5 propylene glycol
5 Pigment Appropriate amount Purified water Amount to make the total 100 Dissolve raw materials equal to or less than chitosan in purified water to obtain a gel skin protectant.

The sample of Example 4 was used by 20 perm technicians, and all 20 answered that they were satisfied with the usability and effect.

(Left below) Example 5 A, chitosan 20% citric acid
10 Lactic acid 1゜Pyrrolidone carboxylic acid 1 Purified water Amount B, making the whole 100, Stearyl alcohol 1 Lanolin alcohol
2 Olive oil 2POE (5
0) Oleyl ether 1 Glyceryl monooleate 1 Fragrance Appropriate amounts of water phase component A and oil phase component B are respectively heated and dissolved at 70°C, and B is added to A to emulsify. Thereafter, a cooling treatment is performed to obtain a cream-like skin protectant.

The sample of Example 5 was used by 20 perm technicians, and 20 of them answered that they were satisfied with the usability and effect.

Claims (1)

[Claims] A skin protection agent characterized by containing chitosan salt.